589

Miconazole Nitrate (BANM, USAN, r/NNM) Local irritation and sensitivity reactions may occur when Microbiological interactions. A study in vitro indicating miconazole nitrate is used topically; contact dermatitis has antimicrobial synergism of miconazole and benzoyl per­ Miccinazol, ninato de; Micortazole, Nitrate de; Miconazo!i been reported. oxide against Staphylococcus spp. and Propionibacterium Nitras; Miconazoinitrat; Mikonatsoiinitraatti; ikonazo! Nitrat; After the intravenous infusion of miconazole, phlebitis, acnes.1 Mikonazolnitrat; Mikonazol-nitrat; MikonazoloM nitratas; nausea, vomiting, diarrhoea, anorexia, pruritus, rash, For the effect on antifungal activity of giving azoles and Mikonazoiu azotan; Nitrate de micon&zol; R-14889; febrile reactions, flushes, drowsiness, and hyponatraemia amphotericin B together. see p. 572.3. Mlimidazole antifungal used as miconazole ProprietaryPreparations (details are given in Volume B) Systemic use of miconazole should be avoided in patients base or nitrate in the treatment of superficial candidiasis Daktarin; Deralbine; Gyno­ with hepatic impairment; Single-ingredient Preparations. Arg.: (p. 564. 1 ), and of the skin infections dermatophytosis and tran; Miconol; Micopul; Mirotgez; Micotral; Micotrim P; Moni­ Intravaginal preparations of miconazole may damage pityriasis versicolor (p. 568.1). It has also been given zol; Nedis; Austral.: Daktarin; Hairscience Anti-Dandruff; intravenously by infusion in the treatment of disseminated latex contraceptives and additional contraceptive measures Resolve Thrush; Resolve Tinea; Resolve; Austria: Daktarin; fungal infections, but other azoles are now more commonly are therefore necessary during local application. Belg.: Daktarin; Gyno-Daktarin; Tibozole; Braz.: Amicozol; used. Miconazole has been fetotoxic at high doses in animals Anfugitarin; Ciconazol; Colpadak; Dakgrant; Daktarin; Dakta­ Miconazole may be given orally as a gel containing and its use is generally not recommended during pregnancy. zol; Dermalina; Ginedakt; Gino Mizonol; Gino-Daczol; Ginotar­ 20 mg/g (24mg/mL) for the treatment and prevention of For a discussion of the caution needed when using azole in; Gyno Daknax; Gyno-Daktarin; Micofim; Micogyn; Micotar­ oropharyngeal and intestinal candidiasis. The usual adult antifungals during pregnancy, see under Pregnancy in int; Micotrint; Micozen; Mizonol; Mycosint; Vodol; Canad.: dose is 5 to 10mL four times daily (equivalent to a total of Precautions of Fluconazole, p. 579.3. Micatin; Micozole; Monistat Derm; Monistat; Chile: Daktarin; ZeaSorb AFt; Ao Xian Ning (�:1C'r); Bai Ni Duo (ff!il about 15 mg/kg daily). For the treatment of oral lesions the China: Porphyria. The Drug Database for Acute Porphyria, com­ $); Beikang Daktarin (it:l'l:'r);Le Wei Qingkun oral gel is applied directly. Miconazole may also be given piled by the Norwegian Porphyria Centre (NAPOS) and OW±$); Wu Mei Cz.: Loramyc; Denm.: Brentan; Fin.: once daily as a muco-adhesive buccal tablet (containing (iiiI.#); (?J'JB); the Porphyria Centre Sweden, classifies miconazole (for Daktarin; Gyno-Daktarin; Loramyct; Fr.: Daktarin; Gyno­ 50 mg miconazole) for the treatment of oropharyngeal (fr:l&); dermatological use) as probably not porphyrinogenic; it Daktarin; Loramyc; Ger.: Castellani mit Miconazol; Daktar; candidiasis in immunocompromised patients. may be used as a drug of first choice and no precautions Derma-Mykotralt; Fungur Mt; Gyno-Daktar; Gyno-Mykotral; Miconazole nitrate is usually applied twice daily as a 2% InfectoSoor; Loramyc; Micobetat; Micotar; Mykoderm Mund­ are needed. Stomatological preparations are classified as cream, lotion, or powder in the treatment of fungal Gel; Mykodenn; Mykotin; Vobamyk; Gr.: Crimak; Daktarin; not porphyrinogenic; they may be used as drugs of first infections of the skin including candidiasis, dermatophy­ Fantersol; Gnostoderm; Gyno-Daktarin; Iristop; Medacter; choice and no precautions are needed.1 tosis, and pityriasis versicolor; it may be applied once or Mezolitan; Untano; Hong Kong: BF-Micozot; Daktarin; Der- twice daily to treat fungal nail infections. In the treatment of l. The Drug Database for Acute Porphyria. Available at: http://www. mon; Fungat; Microtint; Tinazolt; Uni-Mizolet; Zarint; India: drugs-porphyria.org (accessed 24110/ll) 1 vaginal candidiasis, 5 g of a 2% intravaginal cream is Candistat; Candizole; Canticid; Daktarin; Decanazole; Emicona­ inserted into the vagina once daily for 10 to 14 days or twice zole; Fungitop; Gyno-Daktarin; Micogel; Miconit; Micoptic; daily for 7 days. Miconazole nitrate pessaries may be Interactions Micoson; Mizole; Zole; Indon.: Daktarin; Daktazol; Fungares; Puntas; Micoskin; Micrem; Moladerm; Mycorine; Sporend; inserted in dosage regimens of 100 mg once daily for 7 or 14 Miconazole can inhibit the metabolism of drugs metabolised Zolagel; Daktarin; Gyno-Daktarin; Daktarin; Fungi­ days, 100 mg twice daily for 7 days, 200 or 400 mg daily for 3 Irl.: L5rael: by the cytochrome P450 isoenzymes CYP3A4 and CYP2C9. derm; Gyno-Daktarin; Pitrion; Zimycant; Ital.: Daktarin; Mico- days, or in a single dose of 1200 mg. and may thus have effects similar to those of fluconazole 1 nal; Micotef; Midermt; Nizacol; Prilagin; Jpn: Florid; Malaysia: For details of miconazole use in children, see below. (p. 580.1). Miconazole may enhance the activity or serum Antifungal; Becarin; Daktarin; Decozol; Derman; Resolve; concentrations of oral anticoagulants, sulfonylurea hypo­ Zarin; Mex. : Aloid; Biodantyl-C; Daktarin; Dermifun; Falernol; Administration in children. Miconazole may be used in glycaemics, or phenytoin. Adverse effects have been Fucoderm; Fungicremt; Fungiquim; Ginazolt; Gyno-Daktarin; children for the treatment and prevention of oropharyn­ reported when miconazole was given with carbamazepine. Hipo Femme; K-Mizol; Lotrimin AF; Micoffen; Nacomic; Neo­ geal and intestinal candidiasis. In the UK, the oral gel There is a risk of cardiac arrhythmias if oral miconazole is micol; Nimicon; Niscamil; Oz Crema; Vigasil; Neth.: Daktarin; (containing miconazole 20 mg/g) may be given to children used with substrates of CYP3A4 that may prolong the QT Dermacure; Gyno-Daktarin; Kruidvat Antischimrnelcreme; from 4 months of age for oral infections in the following interval, such as, astemizole, cisapride, dofetilide, halo­ Kruidvat Antischimmelpoeder; Loramyc; Zimycant; Norw.: licensed doses: fantrine, mizolastine, pimozide, quinidine, sertindole, or Daktar; NZ: Daktarin; Fungot; .Micozole; Micreme; Monistat; 4 months to 2 years of age: 1.25 mL 4 times daily terfenadine and such combinations should be avoided. Philipp.: Daktarin; De-Ol; Defungint; Emizole; Fungtopic; • Micoson; Micotran; Monistat; Daktarin; Gyno-Femidazol; from 2 years of age: 2.5 mL 4 times daily Pol.: • Loramyc; Miconal; Daktarin; Gyno-Daktarin; Zimycant; Although unlicensed for use in younger children, the BNFC Anticoagulants. The anticoagulant activity of coumarin Port. : Rus.: Daktarin ()J;aKTapHH)t; Gynezol (nme3on); Micoson suggests that a dose of 1.2 5 mL 4 times daily may also be anticoagulants can be potentiated by Iniconazole given (Mrnco3oH); Covarex; Daktarin; Dermazole; Gyno­ orally, 1 intravaginally. 2 or topically -' As of December 2002 S.Afr.: used in children as young as 1 month; for. neonates, a dose Daktarin; Gynosport; Micmat; Singapore: Antifungal; Candi­ of 1 mL 2 to 4 times daily is recommended. the Australian Adverse Drug Reactions Advisory Commit­ plas; Daktarin; Decozol; Guardian Antifungal; Liconar; Micon; For intestinal infections in children from 4 months of tee had received 18 reports of significant increases in the Minazol; Mycoban; Resolve; SP-Micozol; Tinazol; Zarin; Spain: age miconazole oral gel is given in a daily dose of 20 mg/kg INR of patients previously stabilised on warfarin within Daktarin; Fungisdin; Pasedont; Swed.: Daktar; Switz.: Daktarin; (to a maximum of 1 g) in 4 divided doses. to 2 weeks of starting treatment with miconazole oral gel.4I Monistat; Sebolox; Thai.: Daktarin; Dermont; Funcort; Funga; Miconazole nitrate may be used topically to treat fungal l. Ortin M, et al. Miconazole oral gel enhances acenocoumarol Fungi-M; Fungisil; Mict; Micazin; Mysocort; Nikarin; Noxrax­ skin and nail infections in neonates and children similarly to anticoagulant activity: a report of three cases. Ann Pharmacother 1999; in; Podakrin; Ranozol; Skindure; Tara; Turk.: Fungucit; Lotri­ 33: 175-7. adults (see above). min; Miko-Penetran; UAE: Gyno-Mikozal; Mikozal; UK: 2. Lansdorp D, et al. Potentiation of acenocoumarol during vaginal Daktarin; Gyno-Daktarin; Loramyc; Micogel (MHKoreJI&); administration of miconazule. Br J C!in Pharmacal 1999; 47: 225-26. Ukr.: Aloe Vesta; Azolen; Baza Antifungal; Critic-Aid Clear AF; Acanthamoeba keratitis. Miconazole has been applied 3. Devaraj A, et al. Interaction between warfarin and topical miconazole USA: 325: Cruex; Desenex Liquid Sprayt; Desenex Powder; Femizol-Mt; topically in Acanthamoeba keratitis (p. 919.3). cream. BMJ 2002; 77. 4. Australian Adverse Drug Reactions Advisory Committee {ADRAC). , Fungoid; Lotrimin AF; M-Zolet; Micatin; Micro-Guardt; Mira­ Miconazole oral gel elevates INR-a reminder. Aust Adverse Drug React nel AF; Monistat; Neosporin AFt; Oravig; Podactin; Prescription Bull 2002; 21: 14. Available at: http://www.tga.gov.au/adr/aadrb/ Skin disorders. Topical preparations containing an imid­ i· Strength Desenext; Ting; Triple Paste AF; Vagi stat-3; ZeaSorb aadr02l2.pdf {accessed 28/06/05) azole such as ketoconazole or miconazole, usually with AFt; Venez.: Daktarin; Gyno-Daktarin. hydrocortisone, are used in the management of seborrhoeic dermatitis (p. 1689.1). A cream containing miconazole Antimicrobial Action Multi-ingredient Preparations. Arg.: Adenil; Betacort Plus; Blamy; Ciprocort; Colpofilin Max; Cuta Crema; Daktozin; Deli­ nitrate 2% and benzoyl peroxide 5% has been used topi­ Miconazole is an imidazole antifungal with similar san; Denvercrem; Dermizol Trio; Dermosona; Factor Dermico; cally in the treatment of acne (p. 1682.2). antimicrobial activity to that of ketoconazole (p. 587.2). It Fangan Plus; Genamict; Gentasol; Gina] Cent; Ginkan; Gynor­ also has some activity against Aspergillus spp., Cryptococcus mal; Hifamonil Crema; Ladylen; Lazar-Cart Complex; Lichensa; Adverse Effects neoformans, Pseudallescheria boydii,and some Gram-positive Linfol Cicatrizante; Macri}; Mailen; Miklogen; l\1.onizol Cart bacteria including staphylococci and streptococci. Crema; Monizol Cart; Neo Pelvicillin; Ovufem; Ovumix; Pentol; After oral use of miconazole, nausea and vomiting have Protiderm; Septigyn; Tribiocort; Tricifa; Triliver; Triplex; Vagi­ References. been reported, and also diarrhoea (usually on long-term cural Plus; Austral.: Daktozin; Resolve Nappy Rash; Resolve 1. Barasch A, Griffin AV. Miconazole revisited: new evidence of antifungal \ treatment). There have been allergic reactions, rarely, and efficacy from laboratory and clinical trials. Future Microbio/ 2008; 3: 265- Plus; Resolve Tinea; Resolve; Austria: Acne Plus; Vobadenn; isolated reports of hepatitis. 9. Belg.: Acneplus; Daktacort; Daktozin; Braz.: Amplium-G; Anfu-

The symbol denotes a preparation no longer actively marketed t 590

gine; Daktozint; Facyl M; Gino-Colon; Gino-Pletil; Ginosutin­ Preparations Mt; Limpele Ginecologico; Trinizol M; Chile: Doxifen; Exomi­ ······························· ····································································· col; Famidal; Ginecopast Dual; Ginecopast; Ginedazol Dual; ProprietaryPreparations (details are given in Volume B) Ginedazol; Medidos; Mizonase; Tinidazol Compuesto; China: Austria: Exoderil; Can ad.: N a!­ Dapule Cz.: Klion-D; Denm.: Brentacon; Fin.: Single-ingredient Preparations. tint; China: Fang Di Xin Xin Cz.: Exoderil; Ger.: Daktacort; Fr. : Squaphane E; Squaphane P; Squaphane S; (Zilf-*); Exoderilt; Gr.: Exoderil; Hong Kong: Exoderil; Hung.: Exoderil; Squaphane; Squaphane; Ger.: Acne Plus; Decoderm tri; Infecto­ (J'Jll!!); (JlXJlX); Indon.: Exoderil; Israel: Exoderil; Ital.: Suadian; Malaysia: Exo­ Soor; Micotar ZP; Vobadenn; Gr.: Antimycotic; Catrigel; deril; Pol.: Exoderil; Rus.: Exoderil (3K30.IlepiDI); Spain: Micoso­ Combi; Conazol; Daktodor; Decoderm Trivalente-N; Domyco­ nat; Turk.: Exoderil; Ukr.: Exoderil (3K30I\epHJI); USA: Naftin. tin; Edmudo; Expectein; Feminella; Finicort; Flenazole; Flumi­ complex; Fluniprol; Flunovon; Fosemyk; Fumicon; Iflerit; Multi-ingredientPreparations. China: Bi Liang Micoflup; Micogen; Miflert; Milfer; Oxigon; Panderm; Panrnyk; ('iZ•l'f). Sarmel; Verdal; Hong Kong: Axcel Fungicortt; Conazole; PharmacopoeialPreparations Daktacort; Fungo Soothing Balmt; Hydro-Fungat; Micosone; USP 36: Naftifine Hydrochloride Cream; Naftifine Hydrochloride Uni-Mizole-HCt; Zaricortt; Hung.: Klion-D; Mycosolon; India: Gel. Alclos-GM; Atderm; Beclasone-GM; Bedex-GM; Beclomin; Neticonazole is an imidazole antifungal that has been used Beclomin; Beclozen; Becmet-GM; Betamil-GM; Betamil-M; topically in preparations containing of the hydro­ Betanate GM; Betanate M; Betaspi-GM; Betnederm GM; !BAN, usAN, ptNNJ chloride in the treatment of superficial fungalI% infections. Betnovate-GM; Betnovate-M; Betzee-GM; Betzee-M; Candi­ Natamycin fem; Candizole-Tt; CGM; Clobact-GM; Clobaderm-GM; Cloba­ �.ntiblotic A-$283;c�".1 i1625; E255; 1'1ararnklna; NamfJ1y2itie; P epa a ons sia-GM; Clobecos-GM; Clobequad; Cloberis-GM; Clobesym­ ..r. . r ti ...... t-�atan>ycinum: Natamycyna; Natatnysilnl;. Pim�H · Proprietary Preparations (details are given in Volume B) Clofung GM; Clogem; Clomic-M; Clomic-ZM; Clonate-GM; Clop-M; Clop-MG; Clos-GM; Cloto!-GM; Clotof-M; Cortiderm­ Single-ingredientPreparations. Jpn: Atolant. •· > •·• · · . < GM; Cosvate-GM; Cutasol-GM; Daktacort; Daktarin-T; Dandrid; �,,1-!"N()ll"'' .•. • ...... · · . •. < ;4,0./A.B.IO; .. Dermocrat Plus; Dermonit; Dermotel; Dermotriad; Dermotyl­ A'J.(j(,liS ,..- l.lalf.il02; G(/1i\A02;5/JJAAI,O. . M; Dermowin-GM; Drez-V; E-Derm; Edospan; Ecziclo-GM; AT( Vet . -cc.·.Otl.OiAf51AOZ,I\A0;;i,'13; QAQ.i'AA O,J; QlJQ,iMQ2,, QG01M02; Elderm; Enderm-GM; Etan-GM; Eumosone-M; Excel-M; Flual­ M; Flucort-MZ; Flucreme-NM; Flunec; Fungifite; Fungitop-F; Q50iMII)F5().0(852CPO, Gemiderm; Gentacort-FC; GMF; Halostrol-M; Ryton; Kloryl-M; Vt,JI!. .� Labosol-GM; Leobet-GM; Leta-GM; Lobate-GM; Lobate-M; Los­ Pharmacopoeias. In Jpn, Pol., and US. weat; Lozee-GM; Lozee-M; Lupiderm-GM; Lupiderm-M; Meta­ USP 36: (Natamycin). An off-white to cream-coloured zole; Miclogenta; Micocort-G; Micogel F; Micogram; Micolon; powder. It may contain up to 3 moles of water. Practically Mictop-F; Nazo-F; Stecort-NMt; Tenovate M; Valbet; Zole-F; insoluble in water; soluble in glacial acetic acid and in Indon.: Benoson M; Brentan; Daktarin Diaper; Thecort; Zola­ dimethylformamide; slightly soluble in methyl alcohol. A NOTE. The names carbilquinone and carbazylquinone have cort; Zolagel Diaper; Irl. : Daktacort; Israel: Daktacort; Ital. : I% suspension in water has a pH of 5.0 to 7.5. Store in been (possibly erroneously) applied to nifuroxime; Acnidazil; Decoder Micoflu; Malaysia: Daktacort; Decocort; airtight containers. Protect from light. Neo-Penotran; Zaricort; Mex. : Bebektin; Daktacort; Gynotran; however, carbazilquinone is a synonym for the antineo­ Neth.: Acnecare; Daktacort; Norw.: Cortimykt; Daktacort; NZ: plastic carboquone, and care should be taken to avoid Daktacort; Micreme H; Resolve Plus; Philipp.: Acne Plust; Uses and Administration confusion. Daktacort; Neo-Penotran; Pol.: Mycosolon; Port.: Daktacort; Natamycin is a polyene antifungal antibiotic produced by Zamet; Rus.: Klion-D (K.n:HoH-,lJ;); Mycosolon (MHK030JIOH); the growth of Streptomyces natalensis. It is used for the local Neo-Penotran (Heo-IleHOT_PRH); S.Afr. : Acnecleart; Acnidazilt; treatment of candidiasis (p. 564.1) and fungal keratitis (see Daktacort; Elozart; Trialonet; Axcel Fungicort; Con­ Nifuroxime is a nitrofuran antimicrobial that has been used Singapore: Eye Infections, p. 565.3). It has also been used in vaginal azole; Daktacort; Decocort; Micon-H; Neo-Penotran; Tri-Micon; with furazolidone to treat vaginal candidiasis and tri­ trichomoniasis (p. 925.1). Zaricort; Spain: Bexicortilt; Blastoestimulina; Brentan; chomoniasis. A 5% ophthalmic suspension or a l% ointment of Nutracel; Swed.: Cortimyk; Daktacort; Switz.: Acne Creme Plus; natamycin is used in the treatment of blepharitis, Daktacort; Decoderm bivalent; Thai.: Daktacort; Decocortt; P epa a ons ....r ...... r ..ti. .. . Fungisil-T; Kelaplus; Ladocort; Lymarin; Tara-Plus; Timi; Trimi­ conjunctivitis, or keratitis due to susceptible fungi, . . (details are given in Volume B) con; Turk.: Ekze-Mant; Gynotran; Neo-Penotran; Nidazol-M; including Fusarium so/ani. ProprietaryPreparations Natamycin lozenges are used for the treatment of oral Pers-Mant; UK: Acorvio Plus; Daktacort HC; Daktacort; Ukr.: Multi-ingredient Preparations. Mex. : Reuginal. Klion-D (KnHOH-,[(); Mycosolon (MHK030JIOH)t; Neo-Penotran candidiasis in a dose of 10 mg every 4 to 6 hours. Tablets (Heo-IleHOTpaH); Neotrizol (HeoTpmon); USA: Fungoid HC; have been given orally for the treatment of intestinal Vusion; Venez.: Daktozin. candidiasis. Natamycin has also been used topically for fungal skin infections and for candida! and trichomonal infections of the vagina. PharmacopoeialPreparations FUr!gicidln; Nistiltfn; Nist�tlna: Ni$tariMs;i�ts�ti!i; N�statiit\r;. BP 2014: Miconazole and Hydrocortisone Acetate Cream; Nystatille; H!!uirao'l)iltt, • • · · · · · • , · ; . Miconazole and Hydrocortisone Cream; Miconazole and Hydro­ 'CI\S .---..·r t-9. • •· ··... ·········· ····• ····.. ·:··•.·•· ·•·•·• ·•··•• · · <·· :· · · Adverse Effects and Precautions Nystatitlt�m;· .•. Njlst�tyna;·. · . .•... · . · · . cortisone Ointment; Miconazole Cream; Miconazole Oromucosal 41J0..6 'GO!MOt, · • •·•·.·... . ···; ··• . · Gel; Gastrointestinal disturbances have occurred after oral use of � • · •· • ·· AFC e A07M02; DOt!Vta1; .. .. •..•....• ··'>······ · natamycin. Local application has sometimes produced ATC.y r•'7 ()A07A A02; QbQ lt',AOI;.OIJOT.A/i01.. • _. USP 36: Miconazole Injection; Miconazole Nitrate Cream; �DFJO JC721.' . ·.•• ..•.•. ..•. Miconazole Nitrate Topical Powder; Miconazole Nitrate Vaginal irritation. (ny-sialln. A,).. UN!/ .___ (nystatin): Wlt:.X4T9tW,I Suppositories. Pharmacopoeias. In Bur. (see p. vii), Int., Jpn, US, and Viet. Antimicrobial Action Ph. Eur. 8; (Nystatin). An antifungal substance obtained by Natamycin is a polyene antifungal active against Candida fermentation using certain strains of Streptomyces noursei. It and Fusarium spp. In addition it is active against the contains mainly tetraenes, the principal component being nystatin A . The potency is not less than 4400 units/mg and protozoan Trichomonas vagina/is. 1 not less than 5000 units/mg if intended for oral use, calculated with reference to the dried substance. It is a Pharmacokinetics yellow or slightly brownish hygroscopic powder. Practically Natamycin is poorly absorbed from the gastrointestinal insoluble in water and in alcohol; freely soluble in tract. It is not absorbed through the skin or mucous dimethylforrnamide and in dimethyl sulfoxide; slightly membranes when applied topically. After ocular use, soluble in methyl alcohol. Store in airtight containers. natamycin is present in therapeutic concentrations in Protect from light. corneal stroma but not in intra-ocular fluid; systemic USP 36; (Nystatin). A substance, or a mixture of two or absorption does not usually occur. more substances, produced by the growth of Streptomyces noursei (Streptomycetaceae). It has a potency of not less r r<:Jtie>,n, than 4400 units/mg, or, where intended for use in P.. �P.Cl. � ...... extemporaneous preparation of oral suspensions, not less ProprietaryPreparations (details are given in Volume B) than 5000 units/mg. A yellow to light tan, hygroscopic Single-ingredient Preparations. Arg. : Natacyn; China: Natezhen powder, with an odour suggestive of cereals; it is affected by Hydrochloride). Store in Cz.: Pimafucin; Fin.: Pimafucin; Ger.: Infectomyk; long exposure to light, heat, and air. Practically insoluble in containers. Pima(Jl�!j(f;ll; Biciron); Nt; Pimafucint; Hong Kong: Natacynt; Hung.: water and in alcohol; insoluble in chloroform and in ether; Pimafucin; India: Elmycin; Natadrops; Natam; Natamet; Natop­ freely soluble in dimethylformamide and in dimethyl tic; Indon.: Fukricin; Malaysia: Natacyn; Mex. : Miconadna; sulfoxide; slightly to sparingly soluble in methyl alcohol, in Profile Neth.: Pimafucin; Pol.: Pimafucin; Rus.: Pimafucin n-butyl alcohol, and in n-propyl alcohol. A 3% suspension (ITHMaallylamine derivative (see Natacyn; Turk.: Pimafucin; Ukr.: Pimafucin (ITHMa¢yU:HH); Protect from light. Terbinafine, p. 593.3) which is fungicidal against USA: Natacyn. dermatophytes, but only fungistatic against Candida spp. Naftifine hydrochloride I or 2% is applied topically for Multi-ingredientPreparations. Cz. : Pimafucort; Fin.: Pimafucort; Uses and Administration Pimafucort; Pimafucort; Pimafucort; fungal nail and skin infections, particularly dermatophytosis Hung. : Neth.: NZ: Pol.: Nystatin is a polyene antifungal antibiotic used for the Pimafucort; Port.: Pimafucort; Rus.: Pimafucort (IlHMa¢YKopT); ) prophylaxis and treatment of candidiasis of the skin and (see Skin Infections, p. 568.1 . Ukr.: Pimafucort (IlHMa¢yKopT). Local reactions such as burning or stinging may occur. mucous membranes (see p. 564.1). It has been used with Pharmacopoeial Preparations antibacterials in various regimens to suppress the over­ Reviews. USP 36: Natamycin Ophthalmic Suspension. growth of gastrointestinal flora and as part of selective 1. Gupta et al. Naftifine: a review. J Cutan Med Surg 2008; 12: 51-8. AK, decontamination regimens (see Intensive Care, p. 187.3).

All cross-references refer to entries in Volume A