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WO 2008/121355 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date (10) International Publication Number 9 October 2008 (09.10.2008) PCT WO 2008/121355 Al (51) International Patent Classification: #100-131, Gilbert, AZ 85296 (US). HILL, John, C. A61K 8/02 (2006.01) [US/US]; 5008 E. Dallas Street, Mesa, AZ 85205 (US). (74) Agent: GILMORE, Douglas, W ; Noblitt & Gilmore, (21) International Application Number: LLC, 4800 North Scottsdale Road, Suite 6000, Scottsdale, PCT/US2008/004120 AZ 85251-7630 (US). (22) International Filing Date: 29 March 2008 (29.03.2008) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, (26) Publication Language: English CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, (30) Priority Data: IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, 60/920,604 29 March 2007 (29.03.2007) US LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, (71) Applicant (for all designated States except US): IN¬ PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, TERNATIONAL FLORA TECHNOLOGIES, LTD. SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, [US/US]; 291 East El Prado Court, Chandler, AZ 85225 ZA, ZM, ZW (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors; and kind of regional protection available): ARIPO (BW, GH, (75) Inventors/Applicants (for US only): RHEINS, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, Lawrence, A. [US/US]; 6515 W. Honeysuckle Drive, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), Glendale, AZ 85310-1806 (US). ASHLEY, David, A. European (AT,BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, [US/US]; 3602 E. Glenrosa Street, Apt. 1, Phoenix, FR, GB, GR, HR, HU, IE, IS, IT, LT,LU, LV,MC, MT, NL, AZ 85018 (US). REINHARDT, John [US/US]; 1652 NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, Kingsport Drive, Riverside, CA 92506 (US). BROWN, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). James, H.; 5214 E. Paradise Dr., Scottsdale, AZ 85254 Published: (US). BROWN, James, S. [US/US]; 891 E. Warner Road, — with international search report (54) Title: MANAGEMENT OF DERMATITIC SYMPTOMS OF MAMMALIAN INTEGUMENT WITH EMOLLIENT DISIN FECTANT FORMULATIONS Transepidermal Water Loss (TEWL) M FIG. 1 (57) Abstract: Botanically-sourced and botanically-derived emollient sanitation compositions for topical use are disclosed. Rep- resentative compositions generally aid reconstitution of the lipid profile of the stratum corneum (310) by providing botanical lipids and/or lipid-derivatives that resemble human sebum - these components being ordinarily diminished with the use of conventional hand sanitizer products. Disclosed features and specifications may be variously controlled, adapted or optionally modified to re alize, for example, improved hand sanitizer formulations. Representative embodiments of the present invention generally provide anti-microbial compositions blended with botanically sourced lipids and/or lipid-derivatives to control or otherwise improve der- matitic symptoms (e.g., 320) associated with frequent use of conventional hand sanitizer products. IN THE UNITED STATES PATENTAND TRADEMARK OFFICE Utility Patent Application for: MANAGEMENT OF DERMATITIC SYMPTOMS OF MAMMALIAN INTEGUMENT WITH EMOLLIENT DISINFECTANT FORMULATIONS Inventors: Lawrence A. Rheins (Glendale, AZ); John Reinhardt (Riverside, CA); John C. Hill (Mesa, AZ); Grace Hastings (Chandler, AZ); James H. Brown (Scottsdale, AZ); James S. Brown (Gilbert, AZ) RELATED APPLICATIONS This application claims the benefit of United States Provisional Patent Application Serial No. 60/920,604 filed in the United States Patent and Trademark Office on March 29, 2007 by Lawrence A. Rheins, John C. Hill, Grace Hastings, James H. Brown, and John Reinhardt, and is a continuation-in-part of United States Patent Application Serial No. 10/611,775 filed in the United States Patent and Trademark office on June 30, 2003 by John C. Hill and United States Patent Application Serial No. 09/478,071 filed in the United States Patent and Trademark Office on January 03, 2000 by James H. Brown, Lee Roy Copeland, Robert Kleiman, Sambasivarao Koritala, and Melanie K. Cummings. FIELD OF INVENTION [0002] The present invention generally relates to emollient and sanitation compositions; and more particularly, representative embodiments of the present invention generally concern delivery of emollients in topically applied disinfectant formulations. BACKGROUND OF INVENTION [0003] The spread of infectious disease due to inadequate hand hygiene is generally acknowledged by the scientific community and accepted by the public at large. As reported by the United States National Institute of Allergy and Infectious Diseases in 2006, the escalating incidence of nosocomial acquired infections by patients lead to approximately two million (2,000,000) hospital acquired infections per year and approximately ninety thousand (90,000) deaths in the United States alone, as compared to about thirteen thousand (13,000) deaths in 1992. This is especially disturbing due to the rapid development and spread of antibiotic-resistant bacteria, fungi, and parasites as well as antiviral, drug-resistant viruses. Antibiotic resistant strains of disease-causing bacteria, such as Staphylococcus aureus, are now commonly acquired in hospital settings due to close contact of patients who are more susceptible to infection and the extensive use of antibiotics, which generally provide selection pressure for these strains of bacteria. Consequently, people infected with these microbes are likely to have longer hospital stays and may require treatment with second- and third- choice antibiotics that may be less effective and more expensive. [0004] Despite the knowledge that frequent hand washing is an effective preventative measure against the spread of disease-causing microbes, a significant level of healthcare worker non-compliance persists. Although most workers in the healthcare industry are regulated by policies requiring frequent hand washing and/or the use of liquid hand sanitizers, non-compliance with these policies has been reported to be between 45% and 70%. A prominent reason cited for non-compliance is the incidence of acute and chronic irritated skin and, to a lesser extent, contact allergic hand dermatitis due to repeated use of antibacterial soaps and the use of alcohol-based (either ethanol or isopropanol, 60%- 95% wt/wt) hand sanitizers. The use of these sanitizers can be as high as fifty or more times during each work day. [0005] A negative side effect of the use of conventional ethanol hand sanitizers, upon application to the skin, is that they generally operate to remove various surface lipids from the uppermost region of the skin known as the stratum corneum. These lipids typically function to maintain homeostatic balance of the skin. The chronic stripping of the lipid barrier usually results in xerosis, scaling, erythema, rough skin, and tight skin. More serious and painful side effects include inflammation, fissures, allergic contact dermatitis, and the harboring of transient pathogenic organisms that may cause infections. Common sensations associated with de-lipidization include itching, tingling, burning, stinging, and the like. Non-compliance that results from experiencing these types of side effects with the use of conventional hand sanitizers actually leads to further spread of diseases that hand-hygiene guidelines are promulgated with the intent of preventing. [0006] As a mechanism for addressing adverse side effects, many individuals turn to moisturizers, corticosteroids, and the like; however, these mechanisms for replenishing moisture and/or combating dryness and other skin irritations are of limited efficacy when multiple hand cleansing cycles throughout the day are required. This is due to each cleansing cycle operating to remove the previously applied moisturizers as they sit on the uppermost surface of the skin - thereby reducing the exposure of the skin to the moisturizer and the moisturizer's overall effectiveness. Accordingly, there is a need for alternative sanitizer formulations to reduce the negative effects associated with frequent washing while maintaining effective disinfectant function. SUMMARY OF THE INVENTION [0007] In a representative aspect, the present invention provides compositions and methods for providing botanically-sourced and/or botanically-derived topical emollient compositions with disinfectant properties to ameliorate dermatitic symptoms of mammalian integument. The sanitizing component of the composition may include an anti microbial sanitizer. The emollient component of the composition may include botanical lipid materials (and/or their derivatives) selected to demonstrate properties at least partially analogous to mammalian sebum. The combination of sanitizing and emollient components of the resulting formulations may be employed to manage dermatitic symptoms and sanitize mammalian integument. [0008] Advantages of the present invention will be set forth in the Detailed Description which follows and may be apparent in view of the Detailed Description or may be learned by practice of exemplary embodiments of the invention. Still other advantages of the invention may
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