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New Chemistry and New Opportunities from the Expanding Protein Universe Universe Protein Expanding the from Opportunities New and New Chemistry Copyright of the works in this eBook is vested with World Scientific Publishing. The following eBook is allowed for host on http://www.solvayinstitutes.be/ only and may not be resold, copied, further disseminated, or hosted on any other third party website or repository without the copyright holders' written permission. http://www.worldscientific.com/worldscibooks/10.1142/9180 For any queries, please contact [email protected]. distribution is allowed. distribution 9180 only. No further No only. vayinstitutes.be/ PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - http://www.sol host on on host Expanding ProteinUniverse New Opportunities http://www.worldscientific.com/worldscibooks/10.1142/ New Chemistry ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY fromthe and distribution is allowed. distribution 9180 only. No further No only. July 25, 2013 17:28 vayinstitutes.be/ PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - http://www.sol host on on host http://www.worldscientific.com/worldscibooks/10.1142/ This pageintentionallyleftblank WSPC - Proceedings Trim Size: 9.75in x 6.5in icmp12-master ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY 23rd International Solvay Conference on Chemistry New Chemistry and New Opportunities from the Expanding Protein Universe distribution is allowed. distribution Hotel Métropole, Brussels 16 – 19 October 2013 9180 only. No further No only. Scientific Editors vayinstitutes.be/ Kurt Wüthrich PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - The Scripps Research Institute, USA & ETH Zürich, Switzerland Ian A. Wilson http://www.sol The Scripps Research Institute, USA host on on host Donald Hilvert ETH Zürich, Switzerland Dennis W. Wolan http://www.worldscientific.com/worldscibooks/10.1142/ The Scripps Research Institute, USA International Solvay Institutes Editor Anne De Wit ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World Université Libre de Bruxelles, Belgium NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE Library of Congress Cataloging-in-Publication Data International Solvay Conference on Chemistry (23rd : 2013 : Brussels, Belgium) New chemistry and new opportunities from the expanding protein universe : proceedings of the 23rd International Solvay Conference on Chemistry, Hotel Métropole, Brussels 16–19 October 2013 / editor, Kurt Wüthrich, The Scripps Research Institute, USA & ETH Zürich, Switzerl [and 4 others]. pages cm distribution is allowed. distribution Includes bibliographical references and index. ISBN 978-9814603829 (hardcover : alk. paper) -- ISBN 9814603821 (hardcover : alk. paper) -- ISBN 978-9814616560 (pbk. : alk. paper) -- ISBN 9814616567 (pbk. : alk. paper) 9180 1. Proteins--Synthesis--Congresses. 2. Enzymes--Congresses. I. Wüthrich, Kurt, editor. II. Title. QP551.I5188 2013 only. No further No only. 612'.01575--dc23 2014024092 British Library Cataloguing-in-Publication Data vayinstitutes.be/ A catalogue record for this book is available from the British Library. PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - http://www.sol host on on host Copyright © 2014 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the publisher. http://www.worldscientific.com/worldscibooks/10.1142/ For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY Printed in Singapore October 14, 2014 14:31 WSPC Proceedings - 9.75in x 6.5in master/pg v v Contents I. The International Solvay Institutes xi II. Solvay Scientific Committee for Chemistry xiii distribution is allowed. distribution III. Acknowledgements xv IV. Participants xvi 9180 V. Auditors xviii only. No further No only. VI. Opening Address by Professor M. Henneaux xix VII. Preface by Professor K. W¨uthrich xxi Session 1: New Chemistry in the Expanding Protein Universe 1 vayinstitutes.be/ 1.1 Novel Chemistry Still to be Found in Nature 3 PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - C. T. Walsh 1.2 Natural Product Biosynthesis in the Genomic Age 6 http://www.sol W. A. van der Donk host on on host 1.3 Peptide Dendrimers and Polycyclic Peptides 11 J.-L. Reymond 1.4 What can Comparative Genomics Reveal about the http://www.worldscientific.com/worldscibooks/10.1142/ Mechanisms of Protein Function Evolution? 16 N. L. Dawson, R. Studer, N. Furnham, D. Lees, S. Das, J. Thornton and C. Orengo 1.5 Exploring Chromatin Biology Using Protein Chemistry 20 T. W. Muir ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World 1.6 Our Expanding Protein Universe 23 NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY A. Godzik 1.7 The Scientific Impact of Freely Available Chemical Probes 28 A. M. Edwards 1.8 Discussions of Session 1 31 October 14, 2014 14:31 WSPC Proceedings - 9.75in x 6.5in master/pg vi vi Contents Session 2: Exploring Enzyme Families and Enzyme Catalysis 57 2.1 Mechanistic Enzymology and Catalyst Design 59 D. Hilvert 2.2 Looking in New Directions for the Origins of Enzymatic Rate Accelerations 64 J. P. Klinman 2.3 Computational Enzyme Design and Methods to Predict the Role of Remote Mutations 70 distribution is allowed. distribution K. N. Houk 9180 2.4 Discovering Novel Enzymes, Metabolites and Pathways 75 J. A. Gerlt only. No further No only. 2.5 Programming New Chemistry into the Genetic Code of Cells and Animals 79 J. W. Chin vayinstitutes.be/ PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS - 2.6 Expanding the Enzyme Universe through a Marriage of Chemistry and Evolution 84 http://www.sol F. H. Arnold 2.7 Controlled Radical Reactions in Biology and the Importance of host on on host Metallo-Cofactor Biosynthesis 90 J. Stubbe 2.8 Discussions of Session 2 94 http://www.worldscientific.com/worldscibooks/10.1142/ Session 3: Microbiomes and Carbohydrate Chemistry 117 3.1 Structural Basis for Host/Commensal-Microbe Interactions in the Human Distal Gut Microbiome 119 I. A. Wilson ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World 3.2 Carbohydrate Chemistry and Biology 125 NEW CHEMISTRY AND NEW OPPORTUNITIES FROM THE EXPANDING PROTEIN UNIVERSE UNIVERSE PROTEIN EXPANDING THE FROM OPPORTUNITIES NEW AND NEW CHEMISTRY C.-H. Wong 3.3 Chemical Biological Proteomics of Bacterial Protein Functionalities in the Human Distal Gut Microbiome 130 D. W. Wolan October 14, 2014 14:31 WSPC Proceedings - 9.75in x 6.5in master/pg vii Contents vii 3.4 Automated Oligosaccharide Synthesis: From Insights into Fundamental Glycobiology to Vaccines and Diagnostics 136 P. H. Seeberger 3.5 Carbohydrate-Active Enzymes in Microbiomes 141 B. Henrissat 3.6 The Microbiome(s): Microbiota, Families, Functions 146 A. Godzik distribution is allowed. distribution 3.7 N-Linked Protein Glycosylation 150 M. Aebi 9180 3.8 Discussions of Session 3 154 only. No further No only. Session 4: GPCRs and Transporters: Ligands, Cofactors, Drug Development 177 4.1 GPCRs and Transporters: Ligands, Cofactors, Drug Development 179 vayinstitutes.be/ PROCEEDINGS OF THE 23RD INTERNATIONAL SOLVAY CONFERENCE ON ON CHEMISTRY CONFERENCE SOLVAY INTERNATIONAL THE 23RD OF PROCEEDINGS G. von Heijne - 4.2 Studies of GPCR Conformations in Non-Crystalline Milieus 182 http://www.sol K. W¨uthrich host on on host 4.3 The Seven Transmembrane Superfamily 186 R. C. Stevens 4.4 Nanobodies for the Structural and Functional Investigation of GPCR Transmembrane Signaling 192 http://www.worldscientific.com/worldscibooks/10.1142/ E. Pardon and J. Steyaert 4.5 The Hidden Pharmacology of the Human GPCR-ome 195 B. L. Roth 4.6 Structures and Reaction Mechanisms of ABC Transporters 199 ©World Scientific Publishing Company. For For Company. Publishing Scientific ©World
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