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VIJAYKUMAR B. MALASHETTY Professor VIJAYKUMAR B. MALASHETTY Professor |Department of Postgraduate Studies and Research in Zoology| | Vijayanagara Sri Krishnadevaraya University| CONTACT | Jnana Sagara Campus,Vinayaka Nagar| |Cantonment,Bellary 583105| + 91 9343011567 |India| +91 8618558020 [email protected] Academic background Doctor of Philosophy (1999-2005) RESEARCH DESCIPLINE Title : Studies on the antifertility activities of some natural products • Reproductive Biology Department : Zoology • Toxicology Specialization : Reproductive Biology • Reproductive and Supervisor : Prof. Saraswati B. Patil Developmental University : Gulbarga University, Gulbarga Toxicity • Neonatal/ Juvenile Toxicity Master of Science (1997-1999) • Developmental Neurotoxicity Subject : Zoology • Endocrine Disruptors • General Toxicity University : Gulbarga University, Gulbarga Bachelor of Science (1995-1997) Subject : Chemistry, Botany and Zoology Institute : Sharanabasaveshwar College of Science, Gulbarga University : Gulbarga University, Gulbarga P. G. Diploma in Regulatory Affairs (2018) Course : P. G. Diploma in Regulatory Affairs Institute : Global Institute of Regulatory Affairs, Pune 1 | 10 Industrial/Research Experience Vimta Labs Limited, Hyderabad (November 2016- Present) Senior Scientist : November 2016- May 2019 Advinus Therapeutics Limited, Bangalore (June 2008- October 2016) Principal Scientist-II : November 2015 to October 2016 Advinus Therapeutics Limited, Bangalore Principal Scientist-I : June 2011 to November 2015 Advinus Therapeutics Limited, Bangalore Senior Research Scientist : May 2010 to June 2011 Advinus Therapeutics Limited, Bangalore Research Scientist : June 2008 to May 2010 Advinus Therapeutics Limited, Bangalore Indian Institute of Science (IISc), Bangalore (January 2007-May 2008) DBT-Postdoctoral Fellowship (Govt. of India) Supervisor : Prof. Medhamurthy R. Department : Molecular Reproduction, Development and Genetics Institute : Indian Institute of Science (IISc), Bangalore, India Project Title : Generation of transgenic mice over expressing ICER in granulose cells 2 | 10 Toxicology Expertise Advinus Therapeutics Limited and Vimta Labs Limited As a Study Director and Head of Reproductive Toxicology, well experience in preparation of protocols, interpretation of data, review and final report preparation. Supervised the technical operations of the Scientific Resources Unit within the Department of Toxicology. Well versed with the application of OECD, ICH, EPA, Schedule-Y guidelines. Maintaining Research Laboratory as per GLP requirement and facing GLP audits time to time. Specialties Type of Studies (GLP) • Reproduction/Developmental toxicity screening test • Combined repeated dose toxicity study with the reproduction/developmental toxicity • Fertility (SEG-I) study in rats • One generation reproduction toxicity study • Extended one generation reproductive toxicity study • Two/multigeneration reproduction toxicity • Perinatal and postnatal (SEG-III) study in rats • Hershberger and Uterotrophic bioassay in rodents • Neonatal/Juvenile Toxicity • Intravenous Infusion Studies (Tail vein, Femoral vein, Jugular vein) • Dose escalation and MTD studies in Beagle dogs • Repeated dose studies (14, 28, 70 & 90 days, chronic and carcinogenic) in rats, mice, rabbit and dog • Single dose studies • Functional Observation Battery (FOB) tests in rats • Hershberger and Uterotrophic assay in rats Professional Recognition Editorial Board Member and Peer Reviewer for more than 10 national and international journals 3 | 10 Academic Awards/Honors Best Teacher Award : Academic Excellence for two successive years [2005 & 2006] DBT-Post Doctoral Fellowship : Department of Molecular Reproduction, Development and Genetics (MRDG) Indian Institute of Science (IISc), Bangalore Above & Beyonders : In recognition of exceptional teamwork in contributing towards project “Intra-Venous Infusion” by Advinus Therapeutics Limited. CEO Award : In recognition of the outstanding team effort for Safety Assessment during the Joint GLP inspection by NGCMA of India and USFDA during September 10-14, 2012, Advinus Therapeutics Ltd., Bangalore. Vimta Excellence Award : In recognition of outstanding performance and (2017-18) dedication Member of BOE/BOS 1. BOE Member: Dept. of Zoology, Gulbarga University, Kalaburagi. 2. BOS Member: Dept. of Zoology, Gulbarga University, Kalaburagi (2017-19) 3. BOS Member: Dept. of Zoology, Govt. College (Autonomous) Kalaburagi (2017-19) 4. BOS Member: Dept. of Zoology, Sharnbasva University, Kalaburagi (2018-20) List of publications Selected Research Papers 1 Vijaykumar B., Ramanujaneyulu A., Sharanabasappa A. and Saraswati B. Patil (2002). Effect of FSH and LH on testicular activities during nonbreeding season in Calotes versicolor (Daud). Journal of Environmental Biology 23, 43-46. Indexed in PubMed and Scopus 2 Sharanabasappa A., Vijaykumar B. and Saraswati B Patil (2002). Effect of Momordica charantia seed extracts on ovarian and uterine activities in albino rats. Pharmaceutical Biology 40 (7), 501-507. Publisher: Taylor & Francis Group, UK. 4 | 10 3 Vijaykumar B. M., Sangamma I., Sharanabasappa A. and Saraswati B. Patil (2003). Antifertility activity of various extracts of Crotalaria juncea Linn. seeds in male mice. Philippine Journal of Science 132 (1), 39-46. 4 Sharanabasappa A., Vijaykumar B. and Saraswati B Patil (2003). Antispermatogenic and antiandrogenic activities of various extracts of Melia azedarach seeds in albino rats. Orienatal Pharmacy and Experimental Medicine 3(3), 133-140. Publisher: Springer 5 Seetharam Y. N., Sujeeth H., Jyothishwaran G., Barad A., Sharanabasappa G., Umareddy, Vijaykumar B. and Saraswati B. Patil (2003). Antifertility effect of ethanolic extract of Amalakyadi churna in male albino mice. Asian Journal of Andrology 5, 247-250. Publisher: Nature Publishing Group 6 Vijaykumar B. M., Sangamma I., Sharanbasappa A. and Saraswati B. Patil (2004). Antispermatogenic and hormonal effect of Crotalaria juncea Linn. Seed extracts in male mice. Asian Journal of Andrology 6(1), 67-71. Publisher: Nature Publishing Group 7 Viajykumar B. M., Sharanabasappa A. and Saraswati B Patil (2004). Post-coital antiimplantation and pregnancy interruption potency of the seed extracts of Crotalaria juncea. Oriental Pharmacy and Experimental Medicine 4 (2), 70-76. Publisher: Springer 8 Vijaykumar B. M., Sangamma I., Sharanabasappa A. and Saraswati B. Patil (2004). Effect of Crotalaria juncea seed extracts on the estrous cycle and ovarian activity in albino mice. Oriental Pharmacy and Experimental Medicine 4(2), 77-81. Publisher: Springer 9 Mallikarjun P., Sharanabasappa A., Vijaykumar B. M., Saraswati B. P. and Veeranagouda P. (2005). Evaluation of some indigenous plant extracts for antiimplantation activity in albino rats. Oriental Pharmacy and Experimental Medicine 5 (4), 347-351. Publisher: Springer 10 Vijaykumar B. M. and Saraswati B. P. (2006). Spermatogenic index and hormonal profile in the rats received chromatographic fractions of ethanol extract of Crotalaria juncea L. seeds. Oriental Pharmacy and Experimental Medicine 6 (2), 86-95. Publisher: Springer 5 | 10 11 Vijaykumar B. M., Somanathreddy Patil and Saraswati B. P. (2006). Pethidine induced changes in ovarian follicular kinetics and biochemical parameters in albino rats. Oriental Pharmacy and Experimental Medicine 6 (4), 300-305. Publisher: Springer 12 Vijaykumar B. M. and Saraswati B. P. (2007). Monocrotophos induced inhibition of the activities of testis and accessory reproductive organs in male mice. Oriental Pharmacy and Experimental Medicine 7(3), 304-310. Publisher: Springer 13 Vijaykumar B. M. and Saraswati B. P. (2007). Effect of chromatographic fractions of ethanol extract of Crotalaria Juncea (L.) seeds on ovarian follicular kinetics and estrous cycle in albino rats. Iranian Journal of Pharmacology and Therapeutics 6(2), 159-163. 14 Devendra N. K., Vijaykumar B. M., Seetharam Y. N., Suresh P. and Saraswati B. P. (2009). Effect of ethanol extract of whole plant of Trichosanthes cucumerina Var. cucumerina L. on gonadotrophins, ovarian follicular kinetics and estrous cycle for screening of antifertility activity in albino rats. International Journal of Morphology 27(1), 179-188. 15 Vijaykumar B. M., Sonar A., Saraswati B. P. (2009). Anatomy and histophysiological changes in pituitary of Calotes versicolor during breeding and nonbreeding seasons. International Journal of Morphology 27(4), 1223-1234. 16 Devendra N. Kage, Seetharam Y. N. and Vijaykumar B. M. (2009). In Vitro Antibacterial Property and Phytochemical Profile of Trichosanthes Cucumerina L. Var. Cucumerina. Advances in Natural and Applied Sciences 3(3), 438-441. Indexed in Scopus 17 Devendra, N.K., B.M. Vijaykumar and Y.N. Seetharam (2010) Folklore Medicinal Plants of Gulbarga District, Karnataka, India. eJournal of Indian Medicine 3, 1, 53- 60. 18 Devendra, N.K., B.M. Vijaykumar, B. Subhash and Y.N. Seetharam (2010) Phytochemical Profile and Antibacterial Properties of the Fruit and Leaf of the Momordica dioica (Roxb.) Willd. Pharmacology online 3, 207-211. Indexed in Scopus 19 Ghanti, Kiran Kumar S and Sujata, KG and Kumar, Vijaykumar BM and Karba, Nataraja N and Reddy, Janardhan K and Rao, Srinath M and Kishor Kavi PB (2011) Heterologous expression of P5CS gene in chickpea enhances salt tolerance without affecting yield. In: Biologia Plantarum, 55 (4). pp. 634-640. Publisher: Springer 6 | 10 20 Sneha RB , Sharangouda JP, Ravikumar JB, Vijaykumar BM and Saraswati BP (2012) Study of effect of Phenobarbitone on ovarian
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