N-Methylprotoporphyrin IX: Chemical Synthesis and Identification
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On Conducting Polymer Coated Electrodes: a Versatile Platform for the Modification of Electrode Surfacesa
Full Paper http://www.paper.edu.cn ‘‘Click’’ on Conducting Polymer Coated Electrodes: A Versatile Platform for the Modification of Electrode Surfacesa Yan Li, Weixia Zhang, Jing Chang, Jinchun Chen, Guangtao Li,* Yong Ju* Two types of N-substituted pyrroles with azide and terminal alkyne groups have been synthesized and electropolymerized. ‘‘Click’’ chemistry, specifically Huisgen 1,3-dipolar cycloaddition, was used as a general method for functionalization of the polypyrrole films. Several model compounds, including redox active (quinone), bioactive (cholic acid) and recognition elements (carbohydrate and thymi- dine) could easily be attached onto the electrode surfaces without loss of functionality or the elec- troactivity of the underlying conducting polymers. The results suggest that the polypyrrole films are clickable and provide a novel biocompatible and versatile platform for efficient modifications on electrode surfaces. Introduction catalysis.[1,2] A key factor in such investigations and applications is the achievement of an efficient interface The immobilization of functional units, such as electro- between the functional groups and the conductive active, bioactive and biological recognition elements, onto surface.[3,4] conductive surfaces is of enormous interest, both in Compared to various protocols developed for confining studies of functional groups themselves and in numerous functional units onto solid surfaces, electrodeposition of applications ranging from disease diagnosis to electro- conducting polymers offers a simple and -
Heterocycles 2 Daniel Palleros
Heterocycles 2 Daniel Palleros Heterocycles 1. Structures 2. Aromaticity and Basicity 2.1 Pyrrole 2.2 Imidazole 2.3 Pyridine 2.4 Pyrimidine 2.5 Purine 3. Π-excessive and Π-deficient Heterocycles 4. Electrophilic Aromatic Substitution 5. Oxidation-Reduction 6. DNA and RNA Bases 7. Tautomers 8. H-bond Formation 9. Absorption of UV Radiation 10. Reactions and Mutations Heterocycles 3 Daniel Palleros Heterocycles Heterocycles are cyclic compounds in which one or more atoms of the ring are heteroatoms: O, N, S, P, etc. They are present in many biologically important molecules such as amino acids, nucleic acids and hormones. They are also indispensable components of pharmaceuticals and therapeutic drugs. Caffeine, sildenafil (the active ingredient in Viagra), acyclovir (an antiviral agent), clopidogrel (an antiplatelet agent) and nicotine, they all have heterocyclic systems. O CH3 N HN O O N O CH 3 N H3C N N HN N OH O S O H N N N 2 N O N N O CH3 N CH3 caffeine sildenafil acyclovir Cl S N CH3 N N H COOCH3 nicotine (S)-clopidogrel Here we will discuss the chemistry of this important group of compounds beginning with the simplest rings and continuing to more complex systems such as those present in nucleic acids. Heterocycles 4 Daniel Palleros 1. Structures Some of the most important heterocycles are shown below. Note that they have five or six-membered rings such as pyrrole and pyridine or polycyclic ring systems such as quinoline and purine. Imidazole, pyrimidine and purine play a very important role in the chemistry of nucleic acids and are highlighted. -
Combined Experimental and Theoretical Study of Poly(Aniline-Co-Pyrrole) Oligomer
ORE Open Research Exeter TITLE Combined experimental and theoretical study of poly(aniline-co-pyrrole) oligomer AUTHORS Kamran, Muhammad; Ullah, Habib; Shah, Anwar-ul-Haq A.; et al. JOURNAL Polymer DEPOSITED IN ORE 15 March 2016 This version available at http://hdl.handle.net/10871/20729 COPYRIGHT AND REUSE Open Research Exeter makes this work available in accordance with publisher policies. A NOTE ON VERSIONS The version presented here may differ from the published version. If citing, you are advised to consult the published version for pagination, volume/issue and date of publication Combined Experimental and Theoretical Study of Poly(Aniline-co-Pyrrole) Oligomer Habib Ullah*,a,b, Muhammad Kamranb, Salma Bibic, Anwar-ul-Haq A. Shah*,b, Asif A. Tahira, Khurshid Ayub*,d aEnvironment and Sustainability Institute (ESI), University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK bInstitute of Chemical Sciences, University of Peshawar, 25120 Peshawar, Pakistan cNational Centre of Excellence in Physical Chemistry, University of Peshawar, 25120 Peshawar, Pakistan. dDepartment of Chemistry, COMSATS Institute of Information Technology, University Road, Tobe Camp, 22060 Abbottabad, Pakistan * To whom corresponding should be addressed Email: [email protected] Abstract Quantum mechanical calculations are performed to establish the structure of an oligomer of aniline and pyrrole [Poly(Ani-co-Py)], through comparison of experimental and theoretically calculated properties, including conductivity. The copolymer was synthesized through chemical oxidative polymerization and then confirmed from the experimental IR, UV-vis, mass spectra, elemental, XRD, TGA, and SEM analysis. Quantum mechanical calculations are performed at Density Functional Theory (DFT) and Time dependent DFT (TD-DFT) methods for the electronic and spectroscopic properties of the oligomer. -
Reactions of Pyrrole, Imidazole, and Pyrazole with Ozone
Environmental Science Water Research & Technology View Article Online PAPER View Journal | View Issue Reactions of pyrrole, imidazole, and pyrazole with † Cite this: Environ. Sci.: Water Res. ozone: kinetics and mechanisms Technol., 2020, 6,976 Agnes Tekle-Röttering,‡a Sungeun Lim, ‡bc Erika Reisz,d Holger V. Lutze,efgj Mohammad Sajjad Abdighahroudi, e Sarah Willach,e Winfried Schmidt,af Peter R. Tentscher,h Daniel Rentsch, i Christa S. McArdell, b Torsten C. Schmidt *efg and Urs von Gunten*bc Five-membered nitrogen-containing heterocyclic compounds (azoles) belong to potential moieties in com- plex structures where transformations during ozonation can occur. This study focused on the azole–ozone chemistry of pyrrole, imidazole, and pyrazole as model compounds. Reaction kinetics and ozonation products were determined by kinetic and analytical methods including NMR, LC-HRMS/MS, HPLC-UV, and IC-MS. 1 Analyses of reactive oxygen species ( O2, ˙OH, H2O2), quantum chemical computations (Gibbs energies), and kinetic simulations were used to further support the proposed reaction mechanisms. The species-specific 6 −1 Creative Commons Attribution-NonCommercial 3.0 Unported Licence. second-order rate constants for the reactions of ozone with pyrrole and imidazole were (1.4 ± 1.1) × 10 M −1 5 −1 −1 s and (2.3 ± 0.1) × 10 M s , respectively. Pyrazole reacted more slowly with ozone at pH 7 (kapp =(5.6± 0.9) × 101 M−1 s−1). Maleimide was an identified product of pyrrole with a 34% yield. Together with other prod- ucts,formate,formamide,andglyoxal,CandNmassbalancesof∼50% were achieved. Imidazole reacted with ozone to cyanate, formamide, and formate (∼100% yields per transformed imidazole, respectively) with a closed mass balance. -
CONCISE STUDY NOTES for BG 4Th Semester (UNIT: Amines and Heterocyclic Compounds)
CONCISE STUDY NOTES FOR BG 4th Semester (UNIT: Amines and Heterocyclic Compounds) Syllabus Amines: Classification and factors affecting basicity of amines. Mechanistic details (wherever applicable) of methods of formation of alkyl and arylamines through reduction of nitro compounds and nitriles. Gabriel-Phthalamide reaction and Hofmann rearrangement. Mechanisms involved in the formation and reactions of arenediazonium salts including Azo coupling. Heterocyclic compounds bearing one nitrogen atom: Stuctural features of pyrrole, pyrrolidine, pyridine and piperidine and comparative account of their basic strength. Aromaticity and electrophilic substitution reactions of pyrrole and their comparison with those of furan and thiophene.Mechanisms involved in the preparations of Indole and quinoline using Fischer-Indole and Bishlier-Napierlaski syntheses. Amines: Their classification Alkyl, aryl and ar-alkyl derivatives of ammonia are known as amines General formula is RNH2, R2NH, R3NH, where R can be any alkyl, aryl or aralkyl group. Amines are classified in to primary, secondary and tertiary amines depending upon the number of Hydrogen atoms in ammonia replaced by alkyl or aryl group. If one of hydrogen atom in NH3 is replaced by alkyl or aryl group, the derivative of ammonia so obtained is known as primary amine, if two hydrogen atoms in ammonia are replaced by alkyl, aryl or ar-alkyl groups, the derivative obtained is known as secondary amine, while as if all H atoms in ammonia are replaced by alkyl aryl or aralkyl groups, a tertiaty amine is obtained as shown below: The R groups can be alkyl, aryl or aralkyl groups. Further a secondary or tertiary amine may contain same or different R groups. -
Heterocyclic Chemistrychemistry
HeterocyclicHeterocyclic ChemistryChemistry Professor J. Stephen Clark Room C4-04 Email: [email protected] 2011 –2012 1 http://www.chem.gla.ac.uk/staff/stephenc/UndergraduateTeaching.html Recommended Reading • Heterocyclic Chemistry – J. A. Joule, K. Mills and G. F. Smith • Heterocyclic Chemistry (Oxford Primer Series) – T. Gilchrist • Aromatic Heterocyclic Chemistry – D. T. Davies 2 Course Summary Introduction • Definition of terms and classification of heterocycles • Functional group chemistry: imines, enamines, acetals, enols, and sulfur-containing groups Intermediates used for the construction of aromatic heterocycles • Synthesis of aromatic heterocycles • Carbon–heteroatom bond formation and choice of oxidation state • Examples of commonly used strategies for heterocycle synthesis Pyridines • General properties, electronic structure • Synthesis of pyridines • Electrophilic substitution of pyridines • Nucleophilic substitution of pyridines • Metallation of pyridines Pyridine derivatives • Structure and reactivity of oxy-pyridines, alkyl pyridines, pyridinium salts, and pyridine N-oxides Quinolines and isoquinolines • General properties and reactivity compared to pyridine • Electrophilic and nucleophilic substitution quinolines and isoquinolines 3 • General methods used for the synthesis of quinolines and isoquinolines Course Summary (cont) Five-membered aromatic heterocycles • General properties, structure and reactivity of pyrroles, furans and thiophenes • Methods and strategies for the synthesis of five-membered heteroaromatics -
Strecker Degradation Products of Aspartic and Glutamic Acids and Their Amides
Czech J. Food Sci. Vol. 19, No. 2: 41–45 Strecker Degradation Products of Aspartic and Glutamic Acids and their Amides JAN RÖSSNER, JAN VELÍEK, FRANTIEK PUDIL and JIØÍ DAVÍDEK Institute of Chemical Technology Department of Food Chemistry and Analysis, Prague, Czech Republic Abstract RÖSSNER J., VELÍEK J., PUDIL F., DAVÍDEK J. (2001): Strecker degradation products of aspartic and glutamic acids and their amides. Czech J. Food Sci., 19: 4145. Aspartic and glutamic acids, asparagine and glutamine were oxidised with either potassium peroxodisulphate or glyoxal. Non- volatile products were derivatised and analysed by GC/FID and GC/MS. Volatile reaction products were isolated and analysed by the same methods. It was found that the degradation reactions of amino acids are complex. Amino acids are principally degraded via the corresponding α-keto acids to Strecker aldehydes (aspartic acid to oxalacetic and 3-oxopropionic acids and glutamic acid to α-ketoglutaric and 4-oxobutyric acids), which are unstable and decomposed by decarboxylation to the corresponding alde- hydes. Aspartic acid also eliminates ammonia and yields fumaric acid whereas glutamic acid gives rise to an imine, pyroglutamic acid. A recombination of free radicals leads to dicarboxylic acids (succinic acid from aspartic acid, succinic, glutaric and adipic acids from glutamic acid). The major volatile products (besides the aldehydes) are lower carboxylic acids (acetic acid from aspartic acid and propionic acid acid from glutamic acid) that can at least partly arise by radical reactions. In both quality and quantity terms, a higher amount of degradation products arises by oxidation of amino acids by peroxodisulphate. Keywords: Strecker degradation; Strecker aldehydes; amino acids; glyoxal; sodium peroxodisulphate; aspartic acid; glutamic acid; asparagine; glutamine; radicals The reaction of an α-amino acid with an oxidation re- asparagine (Asn) and glutamine (Gln). -
Indole & Pyrrole Synthesis: Cliffsnotes (Richter, 2004)
9/1/04 Richter Indole and Pyrrole Synthesis: " " Group Meeting Disclaimer: Indole: This lecture will only cover methodology for the construction of the indole and pyrrole ring systems, rather than functionalionalization of pre-existing heterocycles, Nature: which would be the topic of another series of lectures. – The most abundant heterocycle in nature – Found in tryptophan, indole-3-acetic acid (plant growth hormone), Partial List of Transforms Discussed: serotonin (neurotransmitter), natural products, drugs – Isolated industrially from coal tar 1. Batcho-Leimgruber Indole Synthesis – Biosynthesis of tryptophan 2. Reissert Indole Synthesis CO H 3. Hegedus Indole Synthesis 15 2 3 serine 4. Fukuyama Indole Synthesis glucose Steps NH Steps N 5. Sugasawa Indole Synthesis 2 H 6. Bischler Indole Synthesis anthranilate 7. Gassman Indole Synthesis tryptophan 8. Fischer Indole Synthesis 9. Japp-Klingemann Indole Synthesis Reactivity: 10. Buchwald Indole Synthesis C–4 C–3 11. Bucherer Carbazole Synthesis C–5 C–2 12. Japp-Maitland Carbazole Synthesis C–6 N 13. Larock Indole Synthesis C–7 H 14. Bartoli Indole Synthesis 15. Castro Indole Synthesis – Isoelectronic with naphthalene (slightly lower stabilization energy) 16. Hemetsberger Indole Synthesis – Indole has a higher stabilization energy than benzene 17. Mori-Ban Indole Synthesis – Very weakly basic: pKa of protonated indole: –2.4 18. Graebe-Ullmann Carbazole Synthesis – Protonation occurs at C–3 preferentially 19. Madelung Indole Synthesis – Easily oxidized (atmospheric oxygen) – very electron rich 20. Nenitzescu Indole Synthesis – Less prone to oxidation of EWG's on the ring – less electron rich 21. Piloty Pyrrole Synthesis – Electrophilic attack occurs at C–3 (site of most electron density) 13 22. -
Theoretical Study on the Acidities of Pyrrole, Indole, Carbazole and Their Hydrocarbon Analogues in DMSO
Canadian Journal of Chemistry Theoretical study on the acidities of pyrrole, indole, carbazole and their hydrocarbon analogues in DMSO Journal: Canadian Journal of Chemistry Manuscript ID cjc-2018-0032.R1 Manuscript Type: Article Date Submitted by the Author: 13-May-2018 Complete List of Authors: Ariche, Berkane; Modelisation and computational Méthods Laboratory, Faculty of Sciences, University of Saida, Chemistry RAHMOUNI,Draft Ali; Universite Dr Tahar Moulay de Saida, Chimie Is the invited manuscript for consideration in a Special Not applicable (regular submission) Issue?: Keyword: pKa calculation, Aromaticity index, Pyrolle, DMSO, DFT https://mc06.manuscriptcentral.com/cjc-pubs Page 1 of 33 Canadian Journal of Chemistry Theoretical study on the acidities of pyrrole, indole, carbazole and their hydrocarbon analogues in DMSO Ariche Berkane, Rahmouni Ali* Modeling and Calculation Methods Laboratory, University of Saida, B.P. 138, 20002 Saida, Algeria *Corresponding author [email protected] Abstract SMD and IEF-PCM continuum solvation models have been used, in combination with three quantum chemistry methods (B3LYP,Draft M062X and CBS-QB3) to study the acidities of pyrrole, indole and carbazole as well as their hydrocarbon analogues in DMSO, following a direct thermodynamic method. Theoretical parameters such as aromaticity indices (HOMA and SA), molecular electrostatic potential (MEP) and atomic charges have been calculated using B3LYP/6-311++G(d,p) level of theory. Calculated pKa values indicate that there is generally good agreement with experimental data, with all deviations being less than the acceptable error for a directly calculated pKa values. The M062X functional combined to SMD solvation model provide the more accurate pKa values. -
Essentials of Heterocyclic Chemistry-I Heterocyclic Chemistry
Baran, Richter Essentials of Heterocyclic Chemistry-I Heterocyclic Chemistry 5 4 Deprotonation of N–H, Deprotonation of C–H, Deprotonation of Conjugate Acid 3 4 3 4 5 4 3 5 6 6 3 3 4 6 2 2 N 4 4 3 4 3 4 3 3 5 5 2 3 5 4 N HN 5 2 N N 7 2 7 N N 5 2 5 2 7 2 2 1 1 N NH H H 8 1 8 N 6 4 N 5 1 2 6 3 4 N 1 6 3 1 8 N 2-Pyrazoline Pyrazolidine H N 9 1 1 5 N 1 Quinazoline N 7 7 H Cinnoline 1 Pyrrolidine H 2 5 2 5 4 5 4 4 Isoindole 3H-Indole 6 Pyrazole N 3 4 Pyrimidine N pK : 11.3,44 Carbazole N 1 6 6 3 N 3 5 1 a N N 3 5 H 4 7 H pKa: 19.8, 35.9 N N pKa: 1.3 pKa: 19.9 8 3 Pyrrole 1 5 7 2 7 N 2 3 4 3 4 3 4 7 Indole 2 N 6 2 6 2 N N pK : 23.0, 39.5 2 8 1 8 1 N N a 6 pKa: 21.0, 38.1 1 1 2 5 2 5 2 5 6 N N 1 4 Pteridine 4 4 7 Phthalazine 1,2,4-Triazine 1,3,5-Triazine N 1 N 1 N 1 5 3 H N H H 3 5 pK : <0 pK : <0 3 5 Indoline H a a 3-Pyrroline 2H-Pyrrole 2-Pyrroline Indolizine 4 5 4 4 pKa: 4.9 2 6 N N 4 5 6 3 N 6 N 3 5 6 3 N 5 2 N 1 3 7 2 1 4 4 3 4 3 4 3 4 3 3 N 4 4 2 6 5 5 5 Pyrazine 7 2 6 Pyridazine 2 3 5 3 5 N 2 8 N 1 2 2 1 8 N 2 5 O 2 5 pKa: 0.6 H 1 1 N10 9 7 H pKa: 2.3 O 6 6 2 6 2 6 6 S Piperazine 1 O 1 O S 1 1 Quinoxaline 1H-Indazole 7 7 1 1 O1 7 Phenazine Furan Thiophene Benzofuran Isobenzofuran 2H-Pyran 4H-Pyran Benzo[b]thiophene Effects of Substitution on Pyridine Basicity: pKa: 35.6 pKa: 33.0 pKa: 33.2 pKa: 32.4 t 4 Me Bu NH2 NHAc OMe SMe Cl Ph vinyl CN NO2 CH(OH)2 4 8 5 4 9 1 3 2-position 6.0 5.8 6.9 4.1 3.3 3.6 0.7 4.5 4.8 –0.3 –2.6 3.8 6 3 3 5 7 4 8 2 3 5 2 3-position 5.7 5.9 6.1 4.5 4.9 4.4 2.8 4.8 4.8 1.4 0.6 3.8 4 2 6 7 7 3 N2 N 1 4-position -
Combined Experimental and Theoretical Study of Poly(Aniline-Co-Pyrrole) Oligomer
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Open Research Exeter Combined Experimental and Theoretical Study of Poly(Aniline-co-Pyrrole) Oligomer Habib Ullah*,a,b, Muhammad Kamranb, Salma Bibic, Anwar-ul-Haq A. Shah*,b, Asif A. Tahira, Khurshid Ayub*,d aEnvironment and Sustainability Institute (ESI), University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK bInstitute of Chemical Sciences, University of Peshawar, 25120 Peshawar, Pakistan cNational Centre of Excellence in Physical Chemistry, University of Peshawar, 25120 Peshawar, Pakistan. dDepartment of Chemistry, COMSATS Institute of Information Technology, University Road, Tobe Camp, 22060 Abbottabad, Pakistan * To whom corresponding should be addressed Email: [email protected] Abstract Quantum mechanical calculations are performed to establish the structure of an oligomer of aniline and pyrrole [Poly(Ani-co-Py)], through comparison of experimental and theoretically calculated properties, including conductivity. The copolymer was synthesized through chemical oxidative polymerization and then confirmed from the experimental IR, UV-vis, mass spectra, elemental, XRD, TGA, and SEM analysis. Quantum mechanical calculations are performed at Density Functional Theory (DFT) and Time dependent DFT (TD-DFT) methods for the electronic and spectroscopic properties of the oligomer. A very nice correlation is found between the theory and experiment which consequences the structure of Poly(Ani-co-Py). Poly(Ani-co-Py) is not explored like other conducting polymers; however, by tuning this molecular structure, the electro-active nature of this material can be enhanced adequately. KEYWORDS: DFT, Poly(Ani-co-Py), PPy, PANI, Band gap, IR, UV-vis, IP, EA, HOMO-LUMO 2 1. -
Hans Fischer
H ANS F I S C H E R On haemin and the relationships between haemin and chlorophyll Nobel Lecture, December 11, 1930 The Swedish Academy of Sciences has awarded to me the Nobel Prize for my investigations into blood and leaf pigments and for the synthetic prepa- ration of haemin, and I therefore wish to report my results, in so far as this can be done in a brief lecture. The blood pigment haemoglobin is a compound which can be split by diverse methods into its constituents, pigment and protein. Teichmann was the first to observe this cleavage under the microscope when he subjected blood to the effect of glacial acetic acid - common salt; Schalfejeff, Nencki, Piloty, Willstätter and others have used the method on a large scale, so that Teichmann’s crystals are available by the kg. The Swedish scientist Mörner has also developed a method for effecting separation with the aid of alcohol - sulphuric acid, by means of which esters of haemin are obtained. Haemin has the formula C 34 H 32 O 4N 4FeCl. Countless variations of this atomic arrangement are possible. By analytical methods of Nencki, Küster, Piloty, Willstätter, H. Fischer and their pupils, the pyrrole nature of the hae- min was demonstrated, and much information was obtained about its con- stitution. When haemin is deprived of its iron, porphyrins are formed, which are substances having a sensitizing effect, as Hausmann has shown. These porphyrins are widely distributed in Nature, and it was possible to assume as a working hypothesis from the start that there existed a relationship with the porphyrins of blood pigment; it was moreover to be expected that the determination of their constitution would also provide information about the constitution of haemin itself, just as the results of distintegration of bili- rubin which is formed from blood pigment by biological means had stimul- ated determination of the constitution of blood pigment itself.