GLOBAL WATER STUDIES

The effects of naturally occurring in drinking water are unanimous in the U.S., Europe, and Asia. References Small amounts of the element significantly reduce suicide, violence, and drug-related arrests. Studies 1 El-Mallakh, R. S. (1996). Lithium: actions and mechanisms. document the following: Washington, DC: American Psychiatric Press. 2 Schrauzer, G. N. (2002). Lithium: occurrence, dietary intakes, nutritional essentiality. Journal of the American College of 1 A study of lithium content in water in 27 Nutrition, 21(1), 14-21. Texas counties showed that the “incidence 3 Atack, J. R. (2000). Lithium, phosphatidylinositol signaling, and rate of , , and are bipolar disorder. American Psychiatric Press, Inc., Washington DC, suicide homicide rape USA. significantly higher in counties whose drinking 4 Wada, A. (2009). Lithium and neuropsychiatric therapeutics: water supplies contain little or no lithium than in neuroplasticity via glycogen synthase kinase-3, beta-catenin, and counties with water lithium levels ranging from neurotrophin cascades. Journal of pharmacological sciences, (0), 70–170 μg/L.”11 (Content = approx. 2 mg/day) 0905070244. 5 Shao, L., Cui, J., Young, L. T., & Wang, J. F. (2008). The effect of lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience, 151(2), 518-524. 2 The same appeared in Austria in a study 6 Chuang, D. M. (2004). Neuroprotective and neurotrophic actions of of all 99 national districts: “The overall the mood stabilizer lithium: can it be used to treat neurodegenerative suicide rate (R2 = 0.15, β = –0.39, t = –4.14, P = diseases?. Critical Reviews™ in Neurobiology, 16(1&2). 0.000073) as well as the suicide mortality ratio 7 Sassi, R. B., Nicoletti, M., Brambilla, P., Mallinger, A. G., Frank, E., Kupfer, D. J., ... & Soares, J. C. (2002). Increased gray matter (R2 = 0.17, β = –0.41, t = – 4.38, P = 0.000030) volume in lithium-treated bipolar disorder patients. Neuroscience were inversely associated with lithium levels letters, 329(2), 243-245. in drinking water and remained significant 8 Schrauzer, G. N., & Shrestha, K. P. (1990). Lithium in drinking water after sensitivity analyses and adjustment for and the incidences of crimes, suicides, and arrests related to drug socioeconomic factors.”12 addictions. Biological Trace Element Research, 25(2), 105-113. 9 Nieper, H. A. (1973). The clinical applications of lithium orotate. A two years study. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l’agression, 14(6), 407. 3 In Japan “lithium levels were significantly 10 Scientific Opinion of the Panel on Food Additives and Nutrient Sources Lithium and negatively associated with the SMRs added to Food (ANS) on salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements, across 18 municipalities. These findings following a request from the European Commission. The EFSA Journal suggest that even very low lithium levels (2009) 1187, 1-25. http://www.efsa.europa.eu/en/efsajournal/ Orotate may reduce the risk of suicide… It can be doc/1187.pdf. Accessed January 12, 2014. speculated that very low but very long lithium 11 Schrauzer, G. N., & Shrestha, K. P. (1990). Lithium in drinking water exposure can enhance neurotrophic factors, and the incidences of crimes, suicides, and arrests related to drug addictions. Biological Trace Element Research, 25(2), 105-113. neuroprotective factors and/or neurogenesis, 12 Kapusta, N. D., Mossaheb, N., Etzersdorfer, E., Hlavin, G., Thau, K., which may account for a reduced risk of Willeit, M., ... & Leithner-Dziubas, K. (2011). Lithium in drinking water ‡ suicide.13 and suicide mortality.The British Journal of Psychiatry, 198(5), 346- • Supports balanced mood. 350. 13 Ohgami, H., Terao, T., Shiotsuki, I., Ishii, N., & Iwata, N. (2009). Lithium • Naturally supports the body’s self This indisputable data transcends cultural, genetic, and levels in drinking water and risk of suicide. The British Journal of economic differences, leading many researchers to Psychiatry, 194(5), 464-465. regulation of mental and emotional conclude that supplementation of the lithium— outlook.‡ in low doses concurrent with those found in natural wa- ter supplies, combined with physician monitoring—may • Promotes a natural aversion to self reduce episodes of violence to self and to others ‡ . destructive behaviors.‡ The potential impact of low dose lithium orotate, ap- plied to prevent or limit harm in distressed personal GMP Registered www.nsf.org • The most bioavailable form of lithium, lives and families, is too compelling and urgent to Progressive Laboratories, Inc. is and FDA Registered ignore, with much potential to transform suffering and Good Manufacturing Practice Registered by the NSF®. passing easily through the blood-brain and sickness into balance and healthy mental well 1-800-527-9512 • www.progressivelabs.com barrier.‡ being, changing lives.‡ 1701 W. WALNUT HILL LANE • IRVING, TX 75038 #1088 100 Vegetable Capsules Supplement Facts Serving Size: 1 Vegetable Capsule Servings Per Container: 100 Amount Per Serving % Daily Value A Natural Solution Lithium (as lithium orotate) 5 mg †

†Daily Value not established. for Healthy Mood Other Ingredients: hydroxypropyl Management methylcellulose, tapioca starch.

Stress impacts almost everyone, every day. From young students dealing with Why choose to achieve therapeutic results than with drugs using the pressures of school to adults dealing lithium .‡ with the pressures of balancing work and Lithium Orotate? Studies have shown that natural supplementation home. This stress frequently impacts Lithium, a trace element found throughout nature, has with lithium not only balances mood disorders in mood and mental health, including state long been considered a foundation in the treatment the bipolar (depressive/manic) spectrum, but also of mind, emotion, memory and behavior.‡ of bipolar depression. The pharmaceutical form of dramatically affects suicidal ideation, aggression, There are several pharmaceutical lithium, , is also fraught with side violence, and criminal behaviors stemming from products on the market today designed effects.‡ emotional, psychological, environmental and even to help with mood management, and genetic roots.‡ all of them come with a laundry list of Scientists have found that binding small quantities side effects – some of which include an of lithium with orotate salts – in the form of Progressive Laboratories’ Lithium Orotate provides increased risk of suicidal thoughts or lithium orotate – can effectively deliver lithium 5 mg of lithium orotate per vegetable capsule. behaviors!‡ to the brain in dramatically lower doses and with Supplementation with Lithium Orotate supports Highly bioactive with greater healthy mood, emotional wellness, balanced behavior ‡These statements have not been evaluated by the Food and Drug Administration. fewer side effects. This product is not intended to diagnose, treat, cure or prevent any disease. efficacy, much less lithium orotate is needed in order and memory.‡