PADI2 Antibody Cat. No.: 30-805
PADI2 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human PADI2.
TESTED APPLICATIONS: ELISA, WB
PADI2 antibody can be used for detection of PADI2 by ELISA at 1:12500. PADI2 antibody APPLICATIONS: can be used for detection of PADI2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL: 1) Cat. No. 1205 - Jurkat Cell Lysate
PREDICTED MOLECULAR 75 kDa WEIGHT:
Properties
PURIFICATION: Antibody is purified by peptide affinity chromatography method.
CLONALITY: Polyclonal
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
September 25, 2021 1 https://www.prosci-inc.com/padi2-antibody-30-805.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.
CONCENTRATION: batch dependent
For short periods of storage (days) store at 4˚C. For longer periods of storage, store PADI2 STORAGE CONDITIONS: antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Additional Info
OFFICIAL SYMBOL: PADI2
ALTERNATE NAMES: PADI2, KIAA0994, PAD-H19, PAD2, PDI2
ACCESSION NO.: NP_031391
PROTEIN GI NO.: 122939159
GENE ID: 11240
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post- BACKGROUND: translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
REFERENCES: 1) Foulquier, C., (2007) Arthritis Rheum. 56 (11), 3541-3553.
ANTIBODIES FOR RESEARCH USE ONLY.
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