Chronic Pelvic Pain & Pelvic Floor Myalgia Updated
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Opioid-Induced Hyperalgesia in Humans Molecular Mechanisms and Clinical Considerations
SPECIAL TOPIC SERIES Opioid-induced Hyperalgesia in Humans Molecular Mechanisms and Clinical Considerations Larry F. Chu, MD, MS (BCHM), MS (Epidemiology),* Martin S. Angst, MD,* and David Clark, MD, PhD*w treatment of acute and cancer-related pain. However, Abstract: Opioid-induced hyperalgesia (OIH) is most broadly recent evidence suggests that opioid medications may also defined as a state of nociceptive sensitization caused by exposure be useful for the treatment of chronic noncancer pain, at to opioids. The state is characterized by a paradoxical response least in the short term.3–14 whereby a patient receiving opioids for the treatment of pain Perhaps because of this new evidence, opioid may actually become more sensitive to certain painful stimuli. medications have been increasingly prescribed by primary The type of pain experienced may or may not be different from care physicians and other patient care providers for the original underlying painful condition. Although the precise chronic painful conditions.15,16 Indeed, opioids are molecular mechanism is not yet understood, it is generally among the most common medications prescribed by thought to result from neuroplastic changes in the peripheral physicians in the United States17 and accounted for 235 and central nervous systems that lead to sensitization of million prescriptions in the year 2004.18 pronociceptive pathways. OIH seems to be a distinct, definable, One of the principal factors that differentiate the use and characteristic phenomenon that may explain loss of opioid of opioids for the treatment of pain concerns the duration efficacy in some cases. Clinicians should suspect expression of of intended use. -
Pain Management of Inmates
PAIN MANAGEMENT OF INMATES Federal Bureau of Prisons Clinical Guidance JUNE 2018 Federal Bureau of Prisons (BOP) Clinical Guidance is made available to the public for informational purposes only. The BOP does not warrant this guidance for any other purpose, and assumes no responsibility for any injury or damage resulting from the reliance thereof. Proper medical practice necessitates that all cases are evaluated on an individual basis and that treatment decisions are patient- specific. Consult the BOP Health Management Resources Web page to determine the date of the most recent update to this document: http://www.bop.gov/resources/health_care_mngmt.jsp Federal Bureau of Prisons Pain Management of Inmates Clinical Guidance June 2018 TABLE OF CONTENTS 1. PURPOSE OF THIS GUIDANCE.................................................................................................................. 1 2. INTRODUCTION TO PAIN MANAGEMENT IN THE BOP .................................................................................. 1 The Prevalence of Chronic Pain ........................................................................................................ 1 General Principles of Pain Management in the BOP .......................................................................... 2 Multiple Dimensions of Pain Management ................................................................................... 2 Interdisciplinary Pain Rehabilitation (IPR) .................................................................................... 2 Roles -
Aetiology of Fibrositis
Ann Rheum Dis: first published as 10.1136/ard.6.4.241 on 1 January 1947. Downloaded from AETIOLOGY OF FIBROSITIS: A REVIEW BY MAX VALENTINE From a review of systems of classification of fibrositis (National Mineral Water Hospital, Bath, 1940; Devonshire Royal Hospital, Buxton, 1940; Ministry of Health Report, 1924; Harrogate Royal Bath Hospital Report, 1940; Ray, 1934; Comroe, 1941 ; Patterson, 1938) the one in use at the National Mineral Water Hospital, Bath, is considered most valuable. There are five divisions of fibrositis as follows: (a) intramuscular, (b) periarticular, (c) bursal and tenosynovial, (d) subcutaneous, (e) perineuritic, the latter being divided into (i) brachial (ii) sciatic, etc. Laboratory Tests No biochemical abnormalities have been demonstrated in fibrositis. Mester (1941) claimed a specific test for " rheumatism ", but Copeman and Stewart (1942) did not find it of value and question its rationale. The sedimentation rate is usually normal or may be slightly increased; this is confirmed by Kahlmeter (1928), Sha;ckle (1938), and Dawson and others (1930). Miller copyright. and Gibson (1941) found a slightly increased rate in 52-3% of patients, and Collins and others (1939) found a (usually) moderately increased rate in 35% of cases tested. Case Analyses In an investigation Valentine (1943) found an incidence of fibrositis of 31-4% (60% male) at a Spa hospital. (Cf. Ministry of Health Report, 1922, 30-8%; Buxton Spa Hospital, 1940, 49 5%; Bath Spa Hospital, 1940, 22-3%; Savage, 1941, 52% in the Forces.) Fibrositis was commonest http://ard.bmj.com/ between the ages of40 and 60; this is supported by the SpaHospital Report, Buxton, 1940. -
Guidline for the Evidence-Informed Primary Care Management of Low Back Pain
Guideline for the Evidence-Informed Primary Care Management of Low Back Pain 2nd Edition These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. Guideline Disease/Condition(s) Targeted Specifications Acute and sub-acute low back pain Chronic low back pain Acute and sub-acute sciatica/radiculopathy Chronic sciatica/radiculopathy Category Prevention Diagnosis Evaluation Management Treatment Intended Users Primary health care providers, for example: family physicians, osteopathic physicians, chiro- practors, physical therapists, occupational therapists, nurses, pharmacists, psychologists. Purpose To help Alberta clinicians make evidence-informed decisions about care of patients with non- specific low back pain. Objectives • To increase the use of evidence-informed conservative approaches to the prevention, assessment, diagnosis, and treatment in primary care patients with low back pain • To promote appropriate specialist referrals and use of diagnostic tests in patients with low back pain • To encourage patients to engage in appropriate self-care activities Target Population Adult patients 18 years or older in primary care settings. Exclusions: pregnant women; patients under the age of 18 years; diagnosis or treatment of specific causes of low back pain such as: inpatient treatments (surgical treatments); referred pain (from abdomen, kidney, ovary, pelvis, -
Enigma of Myofascial Pain-Dysfunction Syndrome - a Revisit of Review of Literature
e-ISSN: 2349-0659 p-ISSN: 2350-0964 REVIEW ARTICLE doi: 10.21276/apjhs.2018.5.1.03 Enigma of myofascial pain-dysfunction syndrome - A revisit of review of literature Abdullah Bin Nabhan* Oral and Facial Pain Specialist, Department of Dentistry, King Khalid Hospital, Al Kharj, Saudi Arabia ABSTRACT Myofascial pain-dysfunction syndrome (MPDS) is a form of myalgia that is characterized by local regions of muscle hardness that are tender and cause pain to be felt at a distance, i.e., referred pain. The central component of the syndrome is the trigger point (TrP) that is composed of a tender, taut band. Stimulation of the band, either mechanically or with activity, can produce pain. Masticatory muscle fatigue and spasm are responsible for the cardinal symptoms of pain, tenderness, clicking, and limited function that characterize the MPDS. Since MPDS covers a wide range of symptoms, it might be difficult to diagnose and provide definitive treatment. A better understanding and working knowledge of TrPs and MPDS offers an effective approach to relieve pain, restore function, and contribute significantly to patient’s quality of life. Key words: Myalgia, myofascial pain-dysfunction syndrome, referred pain, trigger points INTRODUCTION The main acceptable factors include occlusion disorders and psychological problems.[6,7-10] Muscle pain is a common problem that is underappreciated and often undertreated. Myofascial pain-dysfunction Common etiologies of MPDS may be from direct or indirect trauma, syndrome (MPDS) is a myalgic condition in which muscle and spine pathology, exposure to cumulative and repetitive strain, musculotendinous pain are the primary symptoms and is the postural dysfunction, and physical deconditioning. -
Headache and Chronic Pain in Primary Care
FAMILY PRACTICE GRAND ROUNDS Headache and Chronic Pain in Primary Care Thomas Greer, MD, MPH, Wayne Katon, MD, Noel Chrisman, PhD, Stephen Butler, MD, Dee Caplan-Tuke, MSW Seattle, W a s h in g t o n R. THOMAS GREER (Assistant Professor, Depart automobile accident while vacationing in another state Dment of Family Medicine): The management of pa and suffered multiple contusions and rib fractures. Oral tients with chronic headaches is difficult and often a source methadone had been prescribed at her second clinic visit of discord between the patient and his or her physician. when other oral narcotics failed to control her pain. She The patient with chronic headaches presented in this con also had a long history of visits for headaches, treated with ference illustrates most of the common problems encoun injections of a narcotic, usually meperidine, and oral co tered in the diagnosis, treatment, and management of pa deine. tients with other kinds of chronic pain as well. As her acute injuries healed and she was tapered off the methadone, her chronic headaches emerged as a signifi cant problem. Within a few months the patient was reg EPIDEMIOLOGY ularly requesting oral codeine for the management of her severe, intractable headaches. More than 40 million Americans consult physicians each In early September she was brought to our emergency year for complaints of headache.1 The National Ambu department by ambulance following an apparent seizure. latory Medical Care Survey, which gathered information Witnesses reported that the patient had “jerking move on approximately 90,000 patient visits to a nationally ments.” There was no incontinence; and the ambulance representative sample of physicians, determined that personnel found the patient to be irritable and disoriented headache was the second most common chronic pain but with stable vital signs. -
DSM-IV Pain Disorder in the General Population an Exploration of the Structure and Threshold of Medically Unexplained Pain Symptoms
DSM-IV pain disorder in the general population An exploration of the structure and threshold of medically unexplained pain symptoms Christine Fröhlich,· Frank Jacobi, Hans-Ulrich Wittchen Received: 18 March 2005 / Accepted: 12 September 2005 / Published online: 18 November 2005 Abstract Background Despite an abundance of questionnaire data, the prevalence of clinically significant and medically unexplained pain syndromes in the general population has rarely been examined with a rigid personal-interview methodology. Objective To examine the prevalence of pain syndromes and DSM- IV pain disorder in the general population and the association with other mental disorders, as well as effects on disability and health-care utilization. Methods Analyses were based on a community sample of 4.181 participants 18–65 years old; diagnostic variables were assessed with a standardized diagnostic interview (M-CIDI). Results The 12-month prevalence for DSM-IV pain disorder in the general population was 8.1%; more than 53% showed concurrent anxiety and mood disorders. Subjects with pain disorder revealed significantly poorer quality of life, greater disability, and higher health-care utilization rates compared to cases with pain below the diagnostic threshold. The majority had more than one type of pain, with excessive headache being the most frequent type. Conclusions Even when stringent diagnostic criteria are used, pain disorder ranks among the most prevalent conditions in the community. The joint effects of high prevalence in all age groups, substantial disability, and increased health services utilization result in a substantial total burden, exceeding that of depression and anxiety. Key words: DSM-IV pain disorder, pain syndromes, comorbidity, impairment, Composite International Diagnostic Interview (CIDI) Introduction Chronic pain is well known as a highly prevalent condition in the general population. -
Clinical Data Mining Reveals Analgesic Effects of Lapatinib in Cancer Patients
www.nature.com/scientificreports OPEN Clinical data mining reveals analgesic efects of lapatinib in cancer patients Shuo Zhou1,2, Fang Zheng1,2* & Chang‑Guo Zhan1,2* Microsomal prostaglandin E2 synthase 1 (mPGES‑1) is recognized as a promising target for a next generation of anti‑infammatory drugs that are not expected to have the side efects of currently available anti‑infammatory drugs. Lapatinib, an FDA‑approved drug for cancer treatment, has recently been identifed as an mPGES‑1 inhibitor. But the efcacy of lapatinib as an analgesic remains to be evaluated. In the present clinical data mining (CDM) study, we have collected and analyzed all lapatinib‑related clinical data retrieved from clinicaltrials.gov. Our CDM utilized a meta‑analysis protocol, but the clinical data analyzed were not limited to the primary and secondary outcomes of clinical trials, unlike conventional meta‑analyses. All the pain‑related data were used to determine the numbers and odd ratios (ORs) of various forms of pain in cancer patients with lapatinib treatment. The ORs, 95% confdence intervals, and P values for the diferences in pain were calculated and the heterogeneous data across the trials were evaluated. For all forms of pain analyzed, the patients received lapatinib treatment have a reduced occurrence (OR 0.79; CI 0.70–0.89; P = 0.0002 for the overall efect). According to our CDM results, available clinical data for 12,765 patients enrolled in 20 randomized clinical trials indicate that lapatinib therapy is associated with a signifcant reduction in various forms of pain, including musculoskeletal pain, bone pain, headache, arthralgia, and pain in extremity, in cancer patients. -
AAFP Chronic Pain Toolkit
AAFP Chronic Pain Toolkit PAIN ASSESSMENT | Section 1 OVERVIEW Assessment of chronic pain should be multidimensional. Consideration should be given to several domains, including the physiological features of pain and its contributing factors, with physicians and other clinicians assessing patients for function, quality of life, mental health, and emotional health. In addition to a complete medical and medication history typically obtained at an office visit, documentation should be obtained about pain intensity, location, duration, and factors that aggravate or alleviate pain. A physical exam should include musculoskeletal and neurological components, as appropriate. Diagnostic testing and imaging may also be considered for some types of chronic pain. Many organizations, including the AAFP, recommend against imaging for low back pain within the first six weeks of treatment unless there are reasons for the imaging. These reasons may include concerns of underlying conditions, such as severe or progressive neurological deficits, or if osteomyelitis is suspected.1 Periodic reassessments of chronic pain and treatment should focus on evaluating improvements in physical health; mental and emotional health; progress towards functional treatment goals; and effectiveness and tolerability of medications for chronic pain treatment. Currently, there are no universally adopted guidelines or recommendations for assessment of chronic pain. The use of appropriate assessment tools can assist in diagnostic assessment, management, reassessment, and monitoring of treatment effects. Multiple tools are available, with many embedded in electronic health record (EHR) systems. Pain Assessment Tools The table on the next page includes selected tools for pain assessment included in this toolkit, along with links and reference to additional tools. Assessments about other relevant domains are covered in Functional and Other Assessments (Section 2). -
Pain Management in People Who Have OUD; Acute Vs. Chronic Pain
Pain Management in People Who Have OUD; Acute vs. Chronic Pain Developer: Stephen A. Wyatt, DO Medical Director, Addiction Medicine Carolinas HealthCare System Reviewer/Editor: Miriam Komaromy, MD, The ECHO Institute™ This project is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) under contract number HHSH250201600015C. This information or content and conclusions are those of the author and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS or the U.S. Government. Disclosures Stephen Wyatt has nothing to disclose Objectives • Understand the complexities of treating acute and chronic pain in patients with opioid use disorder (OUD). • Understand the various approaches to treating the OUD patient on an agonist medication for acute or chronic pain. • Understand how acute and chronic pain can be treated when the OUD patient is on an antagonist medication. Speaker Notes: The general Outline of the module is to first address the difficulties surrounding treating pain in the opioid dependent patient. Then to address the ways that patients with pain can be approached on either an agonist of antagonist opioid use disorder treatment. Pain and Substance Use Disorder • Potential for mutual mistrust: – Provider • drug seeking • dependency/intolerance • fear – Patient • lack of empathy • avoidance • fear Speaker Notes: It is the provider that needs to be well educated and skillful in working with this population. Through a better understanding of opioid use disorders as a disease, the prejudice surrounding the encounter with the patient may be reduced. -
UNJ Dec 2000
C o n s e rvative Management of Female Patients With Pelvic Pain Hollis Herm a n he primary symptoms of Female patients with hy p e r t o nus of the pelvic musculature can ex p e- h y p e rtonus of the pelvic rience pain; burning in the cl i t o r i s , u r e t h r a , vag i n a , or anu s ; c o n s t i- m u s c u l a t u r e in female p a t i o n ; u r i n a ry frequency and urge n cy ; and dy s p a r e u n i a . P hy s i c a l patients include pain; t h e r a py techniques are effective in treating female patients with Tb u rning in the clitoris, ure t h r a , pelvic pain, and can successfully reduce the major symptoms asso- vagina or anus; constipation; uri- ciated with it. Using a treatment plan individualized for each patient’s n a ry frequency and urgency; and s y m p t o m s , these techniques can provide considerable relief to d y s p a reu nia (DeFranca, 1996). patients with debilitating pelvic pain. T h e re are many names for hyper- tonus diagnoses involving these symptoms including: levatore s ani syndrome (Nicosia, 1985; Salvanti, 1987; Sohn, 1982), ten- alignment and instability are pre- Olive, 1998), vaginal pH alter- sion myalgia (Sinaki, 1977), sent (Lee, 1999). -
Employees Calling About RTW Clearance
1. Employee should do home quarantine for 7 days Employees calling and consult their physician about RTW clearance 2. Employee must call their own manager to call in Community/General Exposure OR sick as per their usual policy IP&C or Supervisor Confirmed Exposure 3. To return to work, employee must be fever-free without antipyretic for 3 days (72 hours) AND 1. Confirm that employee symptoms improveD AND finisheD 7-day home has finished 7-day home quarantine Community/General/ Travel/ quarantine AND fever-free Day Zero= First Day of Symptoms without antipyretics for 3 CDC Level 2/3 Country* COVID Permitted work on the 8th day days (72 hours) AND Exposure Employee must call the WHS hotline back symptoms have improved then for RTW clearance Employees who call-in 2. Employee should wear Community/General/ 4.Fill out RTW form to place employee off-duty with non-CLI surgical face mask during Unknown COVID Symptoms, but still entire shift while at work exposure (any not feeling well: going forward 3. If employee has been off- exposure that is NOT Please remember to stay duty for 8 or more calendar “Infection Prevention home if you don’t feel days, then email and Control (IP&C) well. Healthcare team confirmed) [email protected] Personnel must not work with doctor’s note simply sick. Follow usual steps stating that they sought for take sick day and care/treatment for COVID- contact their manager. Note: loss of smell/taste alone does If there are NO like symptoms ANY 4.Employee should update NOT constitute CLI per WHS No RTW form needed for symptoms following their manager COVID-19 Symptoms: guidelines Employees with NO non-CLI exposure or travel, 5.