Informa 2021 Half Year Results Presentation
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Genome Editing with CRISPR/Cas9 in Postnatal Mice Corrects PRKAG2 Cardiac Syndrome
Cell Research (2016) 26:1099-1111. © 2016 IBCB, SIBS, CAS All rights reserved 1001-0602/16 $ 32.00 ORIGINAL ARTICLE www.nature.com/cr Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome Chang Xie1, 2, *, Ya-Ping Zhang3, *, Lu Song2, *, Jie Luo1, Wei Qi2, Jialu Hu3, Danbo Lu3, Zhen Yang3, Jian Zhang2, Jian Xiao1, Bin Zhou4, Jiu-Lin Du5, Naihe Jing2, Yong Liu1, Yan Wang1, Bo-Liang Li2, Bao-Liang Song1, Yan Yan3 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China; 2The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; 3Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 4Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sci- ences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; 5Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Acade- my of Sciences, 320 Yue-Yang Road, Shanghai 200031, China PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRK- AG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ventricular tachyarrhythmia and experience progressive heart failure that is refractory to medical treatment and requires cardiac transplantation. In this study, we identify a H530R mutation in PRKAG2 from patients with famil- ial Wolff-Parkinson-White syndrome. By generating H530R PRKAG2 transgenic and knock-in mice, we show that both models recapitulate human symptoms including cardiac hypertrophy and glycogen storage, confirming that the H530R mutation is causally related to PRKAG2 cardiac syndrome. -
2015 Informa Investor Day
2015 Informa Investor Day 18 November 2015 INTRODUCTION STEPHEN A. CARTER GROUP CHIEF EXECUTIVE 2015 Informa Investor Day Presentation Schedule • Introduction • Academic Publishing – Content Depth and Operating Efficiency • Global Exhibitions – Maximising the Growth Opportunity • Greenbuild – Overview & Tour • Lunch • Operational & Financial Update • Summary and Q&A THE JOURNEY SO FAR Stephen Carter appointed 2014 Investor Day Group CEO & launch of Disposal of Consumer Info. strategic review Review of strategic options for European Conferences Gareth Wright confirmed as Group FD, external appointment of BI and K&N Dwell acquisition FIME acquisition CEO’s 2013 2016 2014-2017 Growth Hanley Wood Disposal of Acceleration Plan Exhibitions acquisition Scandinavian announced and placing Conferences New operating Virgo acquisition Orlando Megacon Disposal of Dutch structure announced acquisition Conferences INFORMA GROUP INVESTOR DAY NOVEMBER 2015 4 2014-2017 GROWTH ACCELERATION PLAN FRAMEWORK Growth Acceleration Plan GAP GAP GAP GAP GAP GAP Operating Management Portfolio Acquisition Investment Funding Structure Model Management Strategy • 4 Operating Divisions • EMT established • Consumer Info disposal • Hanley Wood Exhib. • £70-90m programme • Renegotiated RCF • Global Support • Divisional SMTs • InsuranceIQ disposal • Virgo • 30-40 projects • $250m PPP issue • Medical Journals transfer • GE succession • Chinese Pharma closure • Orlando Megacon • 21 projects underway • Group Treasurer • WPA and Learning transfer • 3 yr business plans • Closure -
Ascential Secure
Ascential Secure Enhanced Health & Safety Standards at Ascential’s Events in a Post-COVID-19 World 1 About Ascential Secure Ascential Secure is our approach to enhanced health and safety standards at our events following COVID-19. From exhibitors to sponsors, speakers, visitors and journalists, those who come to our events do so to gain the information, insights, connections, data and digital tools that they need, effectively and safely. The standards and practices that make up Ascential Secure are designed to provide confidence that at every Ascential event, we are striving to provide the highest standards of safety, hygiene, cleanliness and quality. Whether they are exhibitors, attendees, visitors, speakers or sponsors, people come to events to connect, learn, know more and do more business, effectively, safely and with confidence. Ascential Secure is based on a set of event industry standards, called AllSecure. The AllSecure industry standards were developed collaboratively by a group including industry associations UFI, AEO and SISO, event organisers Informa, Reed Exhibitions and Clarion, a range of event venues, suppliers and with input from health, government and local authorities. Ascential Secure is the way these industry-wide AllSecure standards are being applied to Ascential live events. You can expect to see that health and safety continues to be a priority, and that a range of measures are in place to ensure everyone involved is able to enjoy a safe, hygienic, productive and high-quality organised event experience. As a starting point, Ascential Secure events will be run according to the guidance of the government or official local authority for that location, and according to any venue-specific regulations. -
Annual Report 2020
In pursuit of progress since Annual report 2020 report Annual Annual report 2020 In pursuit of progress since Annual report 2020 report Annual Annual report 2020 CONTENTS ANNUAL REPORT STRATEGIC REPORT 2 Five-year summary 3 Group overview 4 From the chairman 6 From the chief executive 8 From the editor 9 Business review: the year in detail 13 The Economist Educational Foundation 15 The Economist Group and environmental sustainability 17 Corporate governance: the Wates Principles, our Section 172(1) statement and our guiding principles REPORT AND ACCOUNTS GOVERNANCE 22 Directors 23 Executive team 24 Trustees, board committees 25 Directors’ report 28 Directors’ report on remuneration 31 Financial review CONSOLIDATED FINANCIAL STATEMENTS 35 Independent auditor’s report to the members of The Economist Newspaper Limited 38 Consolidated income statement 39 Consolidated statement of comprehensive income 40 Consolidated balance sheet 41 Consolidated statement of changes in equity 42 Consolidated cashflow statement 44 Notes to the consolidated financial statements COMPANY FINANCIAL STATEMENTS 94 Company balance sheet 95 Company statement of changes in equity 96 Notes to the company financial statements NOTICES 108 Notice of annual general meeting 1 STRATEGIC REPORT Five-year summary 2020 2019 2018 2017 2016 £m £m £m £m £m Income statement—continuing business* Revenue 326 333 329 303 282 Operating profit 31 31 38 43 47 Profit after taxation 21 25 28 39 37 Profit on sale of CQ-Roll Call, Inc - 43 - - - Profit on sale of Economist Complex - - - - -
Annual Report 2012
BRINGING How we have performed KNOWLEDGE FIN ANCIAL HIGHLIGHTS • Record adjusted diluted EPS up 7.7% to 40.7p (2011: 37.8p), ahead of market expectations TO LIFE • Full year dividend increased by 10.1% – second interim dividend of 12.5p giving a total 2012 dividend of 18.5p (2011: 16.8p) Businesses, professionals and • Revenue broadly flat despite Robbins Gioia and European academics worldwide turn to Informa Conference disposals – £1.23bn (2011: £1.28bn) for unparalleled knowledge, up-to- • Adjusted operating profit up 4.0% to £349.7m the minute information and highly (2011: £336.2m); organic growth of 2.8% specialist skills and services. • Record adjusted operating margin of 28.4% (2011: 26.4%) Our ability to deliver high quality • Adjusted profit before tax of £317.4m up 7.3% (2011: £295.9m) knowledge and services through • Statutory profit after tax of £90.7m (2011: £74.3m) multiple channels, in dynamic and rapidly changing environments, • Strong cash generation – operating cash flow up 5.7% to £329.0m (2011: £311.2m) makes our offer unique and • Balance sheet strength maintained – net debt/EBITDA extremely valuable to individuals ratio of 2.1 times (2011: 2.1 times) and organisations. OPEAI R T ONAL HIGHLIGHTS • Proactive portfolio management drives significant Annual Report & Financial Statements for the year ended December 31 2012 improvement in the quality of Group earnings • Total product rationalisation reduced Group revenue by 2% • Investment in new products, geo-cloning and platform development • Acquisition of MMPI and Zephyr -
Telecommunications Cost Management Auerbach Other 7/31/02 2:44 PM Page 1
AU1101 half-title 7/29/02 1:32 PM Page 1 Telecommunications Cost Management Auerbach Other 7/31/02 2:44 PM Page 1 OTHER AUERBACH PUBLICATIONS The ABCs of IP Addressing Information Security Management Gilbert Held Handbook, 4th Edition, Volume 4 ISBN: 0-8493-1144-6 Harold F. Tipton and Micki Krause, Editors The ABCs of TCP/IP ISBN: 0-8493-1518-2 Gilbert Held Information Security Policies, ISBN: 0-8493-1463-1 Procedures, and Standards: Building an Information Security Guidelines for Effective Information Awareness Program Security Management Mark B. Desman Thomas R. Peltier ISBN: 0-8493-0116-5 ISBN: 0-8493-1137-3 Building a Wireless Office Information Security Risk Analysis Gilbert Held Thomas R. Peltier ISBN: 0-8493-1271-X ISBN: 0-8493-0880-1 The Complete Book of Middleware A Practical Guide to Security Engineering Judith Myerson and Information Assurance ISBN: 0-8493-1272-8 Debra Herrmann ISBN: 0-8493-1163-2 Computer Telephony Integration, 2nd Edition The Privacy Papers: William A. Yarberry, Jr. Managing Technology and Consumers, ISBN: 0-8493-1438-0 Employee, and Legislative Action Rebecca Herold Cyber Crime Investigator’s Field Guide ISBN: 0-8493-1248-5 Bruce Middleton ISBN: 0-8493-1192-6 Secure Internet Practices: Best Practices for Securing Systems in Cyber Forensics: A Field Manual for the Internet and e-Business Age Collecting, Examining, and Preserving Patrick McBride, Jody Patilla, Evidence of Computer Crimes Craig Robinson, Peter Thermos, Albert J. Marcella and Robert S. Greenfield, and Edward P. Moser Editors ISBN: 0-8493-1239-6 ISBN: 0-8493-0955-7 Securing and Controlling Cisco Routers Global Information Warfare: Peter T. -
Department of Life Sciences
THE UNIVERSITY OF THE WEST INDIES Faculty of Science & Technology Department of Life Sciences BIOC 2061 – BIOENERGETICS Category - A- Dr. Adrian Lennon Lehninger Principles of Biochemistry David L. Nelson & Michael M. Cox Category - A- W.H. Freeman Lehninger Principles of Biochemistry Nelson & Cox Category - B- W.H. Freeman 5th Edition Basic Biochemical Methods Renee R. Alexander and Joan M. Griffiths Category - B- Wiley Principles of Biochemistry Robert A. Horton, Laurence A. Moran, Gray Modern Experimental Biochemistry Scrimgeour, Marc Perry and David Rawn Rodney Boyer Prentice Hall 4th Edition Prentice Hall Biochemistry Principles and Techniques of Practical Jeremy Berg, John L. Tymoczko and Lubert Stryer Biochemistry W.H. Freeman 6th Edition Keith Wilson and John Walker Cambridge University Molecular Biology of the Cell Bruce Alberts, Alexander Johnson, Julian Lewis, Data for Biochemical Research Martin Raff Keith Roberts and Peter Walter Rex M. Dawson, Daphn C. Elliot, William H. Elliot Garland Science 5th Edition and Kenneth Oxford University Biochemistry and Molecular Biology of Plants Wilhelm Gruissem Russell L. Jones B.B. Buchanan I.K. International BIOC 2161 – PRIMARY METABOLISM Dr. Valerie Bowrin Bioenergetics David G. Nicholls, Stuart J. Ferguson Category - A- Academic Press 3rd Edition Principles of Biochemistry Nelson, Cox, Lehninger Worth Publishers, 6 March 2002, 3rd Ed. UK. BIOC 2069 PRACTICAL SKILLS IN BIOCHEMISTRY 1 Category -B- Dr. Adrian Lennon Regulation of Enzyme Activity Ottaway, J.H. Oxford University Press Inc. 1988 (paper), Metabolic Regulation: A Human Perspective Biochemistry Frayn, K.N. Berg Jeremy, Tymoczko John & Stryer Lubert Portland Press Ltd. London, 1996 (paper), 5th Edition. W. H. Freeman Category -C- Harper’s Biochemistry Biochemistry 3rd Edition Murray Robert, Granner Darryl, Mayes Peter & Champe, Harvey & Ferrier Rodwell Victor Lippincott’s Illustrated Reviews, ISBN: 0781722659 25th Edition. -
Ranking of Academic Publishers
2016 Ranking of Academic Publishers For book publishers there is no internationally accepted system of ranking. This system is based on those used by SENSE (www.sense.nl) Refereed book publications: A: Refereed book publications published by the world top of publishers B: Refereed book publications published by the world’s semi-top of publishers C: Refereed book publications published by other publishers Rank Publisher A Academic Press A California University Press A Cambridge University Press A Clarendon Press A Cornell University Press A Columbia University Press A Harvard University Press A Hoover Institution Press A John Wiley A John’s Hopkins University Press A MIT Press Cambridge Mass A Oxford University Press A Pennsylvania University Press A Pergamon Press A Stanford University Press A Princeton University A Routledge A Routledge Curzon A Sage A University of Chicago Press A University of Pennsylvania Press A Wiley A Wiley-Blackwell A Yale University Press B Allen and Unwin B American Chemical Society B American Institute of Physics B Australian National University Press B Ashgate B Aspen B Ashgate/Avebury B Basic Books, Inc. B Berg Publishers B Blackwell B Bloomsbury B Birkh├ñuser B Brill B Butterworth-Heinemann B Callwey B Cold Spring Harbor Laboratory Press B Curzon Press B Duke University Press B Earthscan B Edward Elgar B Elsevier Science B Frank Cass B Garrisberg MacMillan B Harcourt Brace Jovanovich, Inc. B Harper & Row Publishers, Inc./Ballinger Publishing Co. B Harwood Academic Publishers B Hart B Heinemann B Humana Press B IEEE B IEEE Computer Society B Indiana University Press B Island Press B James Currey B Karger Publishers B Karthala B Kegan Paul International B Kluwer Academic Publishers B Kluwer Law International B Lexington Books B Lippincott Williams & Wilkins B Lit Verlag B Lynn Rienner Publishers B M.E.Sharpe Inc. -
Informa 2018 Full Year Results Statement
Informa LEI: 5493006VM2LKUPSEDU20 Press Release 7 March 2019 Informa PLC Results for 12 Months to 31 December 2018 2018: Combination & Creation 2019: Performance & Growth KEY FINANCIAL AND OPERATING HIGHLIGHTS1 • Strong Revenue Growth: +3.7% underlying and +34.9% reported to £2,369.5m, including six months of UBM (2017: £1,756.8m) • Higher Adjusted Operating Profit: +2.3% underlying and +34.4% reported to £732.1m (2017: £544.9m) • Improved Statutory Operating Profit: £363.2m (2017: £344.7m) • Increased Adjusted Diluted Earnings per Share: +7.0% to 49.2p (2017: 46.0p); Statutory EPS of 19.7p (2017: 37.6p), with prior year including non-cash credit from US tax reforms • Attractive Free Cash Flow: £503.2m and £600m+ including a full year of UBM (2017: £400.9m) • Robust Balance Sheet, in line with plan: Net debt/EBITDA1 at 2.9x (2017: 2.5x) • Enhanced Dividend: up 7.1% to 21.90p (2017: 20.45p) London: Informa (LSE: INF.L), the International Exhibitions, Events, Information Services and Scholarly Research Group, today published its financial results for the 12 months to 31 December 2018, reporting a further period of operational progress and improving financial performance. Stephen A. Carter, Group Chief Executive, said: “In 2018, the Informa Group delivered a fifth consecutive year of improving growth, increasing adjusted profits, adjusted earnings per share, cashflow and dividends.” He added: “In 2019, our focus is on continuing Performance and Growth as we consolidate our market positions and further reduce complexity. This will enable -
The EBRARY Platform
One eContent platform. Many ways to use it. Subscribe, Purchase or Customize Share, Archive & Distribute Integrate THE EBRARY PLatFORM Our eContent Your eContent eBooks, reports, journals, Theses, dissertations, images, journals, sheet music, and more eBooks – anything in PDF Subscribe Purchase Customize Share Archive Distribute SULAIR Select Collections SUL EBRARY COLLECTIONS Select Collections TABLE OF CONTENTS Infotools All ebrary Collections CONTRIBUTORS Byron Hoyt Sheet Music (Browse) INTRODUCTION Immigration Commision Reports (Dillingham) Contents BUSINESS: A USER’S GUIDE Women and Child Wage Earners in the U.S. CSLI Linguistics and Philosophy BEST PRACTICE SUL Books in the Public Domain MANAGEMENT CHECKLISTS Medieval and Modern Thought Text Project ACTIONLISTS MANAGEMENT LIBRARY BUSINESS THINKERS AND MANA DICTIONARY WORLD BUSINESS ALMANAC Highlights Notes BUSINESS INFORMATION SOURC INDEX CREDITS InfoTools Integrates Define Explain Locate multiple online Translate Search Document... resources Search All Documents... Search Web Search Catalog with one Highlight Add to Bookshelf customizable Copy Text... Copy Bookmark interface. Print... Print Again Toggle Automenu Preferences... Help About ebrary Reader... EASY TO USE. Subscribe, Purchase AFFORDABLE. or Customize your ALW ay S AVAILABLE. eBook selection NO CHECK-OUTS. Un I Q U E S U B SC R I B E T O G R OWI ng E B O O K D ataba S E S W I T H SIMULtanEOUS, MULTI-USER ACCESS. RESEARCH TOOLS. ACADEMIC DATABASES Academic Complete includes all academic databases listed below. FREE MARCS. # of # of Subject Titles* Subject Titles* Business & Economics 6,300 Language, Literature 3,400 & Linguistics “ebrary’s content is Computers & IT 2,800 Law, International Relations 3,800 multidisciplinary and Education 2,300 & Public Policy Engineering & Technology 3,700 supports our expanding Life Sciences 2,000 (includes Biotechnolgy, History & Political Science 4,800 Agriculture, and (also includes a bonus selection faculty and curriculum. -
Global Business Information Specialist Informa’S Book Business Has More Than 55,000 Academic Advisers 26 Directors’ Report 27 and Business Titles
Business Profile Business WHO WE ARE Business Profile 02 Annual Report & Financial Statements 2009 Our Business 03 Informa at a Glance 04 Academic Information 06 Professional & Commercial Information 08 Events & Training 10 Informa plc is a leading international provider of specialist information and services for the academic and scientific, professional and commercial business communities. Informa has some 150 offices in over 40 countries and employs approximately 8,000 staff around the world. Informa is the largest publicly-owned organiser of conferences and courses in the world with inThe Year The Year in Review 12 an output of around 8,000 events annually. Informa Financial Highlights 13 publishes over 2,100 subscription-based information Chairman’s Statement 14 services including academic journals, real-time news Chief Executive’s Review 16 Financial Review 19 R and structured databases of commercial intelligence. Board of Directors 24 eview Global Business Information Specialist Informa’s book business has more than 55,000 academic Advisers 26 Directors’ Report 27 and business titles. Corporate Governance Statement 38 Directors’ Remuneration Report 45 Corporate Responsibility 55 Financial Statements Financial Financial Statements 58 Independent Auditors’ Report – Group 59 Consolidated Income Statement 60 Consolidated Statement of Comprehensive Income 61 Consolidated Statement of Changes in Equity 62 Consolidated Statement of Financial Position 64 ”It was an extremely demanding year, Consolidated Cash Flow Statement 65 but one which -
Delivering a Sustainable Expo
DELIVERING A SUSTAINABLE EXPO Expo 2020 Dubai Sustainability Report 2018 “We pay the utmost care and attention to our environment for it is an integral part of the country, our history and our heritage. Our forefathers and our ancestors lived in this land and coexisted with its environment, on land and sea, and instinctively realised the need to preserve it.” LATE SHEIKH ZAYED BIN SULTAN AL NAHYAN Founder of the UAE “Protection of the environment and achievement of sustainable development in the UAE is a national duty; it has its own institutional structures, integrated legislature and advanced systems.” HIS HIGHNESS SHEIKH KHALIFA BIN ZAYED AL NAHYAN President of the United Arab Emirates “We are building a new reality for our people, a new future for our children, and a new model of development.” HIS HIGHNESS SHEIKH MOHAMMED BIN RASHID AL MAKTOUM Vice-President and Prime Minister of the UAE and Ruler of Dubai “The civilised, advanced nation we seek to build and the sustainable development we are keen to achieve both require concerted efforts from all sectors of the community and from all public and private entities and organisations. They require consistent and harmonious work in order to achieve our goals and promote and underpin our nation’s status with its distinct role regionally and internationally.” HIS HIGHNESS SHEIKH MOHAMED BIN ZAYED AL NAHYAN Crown Prince of Abu Dhabi and Deputy Supreme Commander of UAE Armed Forces INTRODUCTION HIS HIGHNESS SHEIKH AHMED BIN SAEED AL MAKTOUM President, Dubai Civil Aviation Authority Chairman of the Expo Dubai 2020 Higher Committee It gives me great pleasure to introduce the first Expo 2020 Dubai Sustainability Report (2018) as we build up to the World Expo in 2020.