CURRICULUM VITAE
Professor Carlos Simón MD, PhD.
1 Contents Contact Details...... 3 Qualifications...... 3 Current Appointments...... 3 Fellowships...... 3 Registration...... 3 Visiting Professorships...... 3 Affiliations, Member of Societies...... 4 Board Membership...... 4 National Research Committees...... 4 Scholarships and Awards...... 4 Previous Appointments...... 6 Current Institutional Affiliation...... 6 Committees and Leadership...... 6 Peer Review Granting Bodies...... 7 Involvement in Scientific Disciplines...... 8 Panel of Referees for Granting Bodies...... 8 Panel of Referees for Professional Journals...... 8 Previous, and Current Research Experience...... 10 Research Interest...... 10 Patents...... 11 Commercial Translation of Research...... 11 Governmental Grants Held as PI...... 11 Grants from Scientific Societies and Pharma Companies Held as PI...... 15 Publications...... 18 Summary of Educational Accomplishments (CME)...... 57 Invited Seminars / Symposium Presentations International Invitations...... 62 Invited Seminars / Symposium Presentations National Invitations...... 77 Undergraduate & Postgraduate Teaching, Past & Present Students...... 82 Conference Organization...... 85 Conference Presentations & Abstracts...... 87
2 Curriculum Vitae Professor Carlos Simón MD, PhD.
Contact Details Igenomix SL Calle Narcís Monturiol Estarriol nº11 Parcela B, Edificio Europark Parque Tecnológico de Paterna 46980 - Paterna Valencia, Spain Tel: +34 963905095 (EA Susana Chorro) Movil: +34 639 125 447 Fax: +34 96 390 2522 Email: [email protected] Webs: www.carlos-simon.com ; Igenomix Qualifications 1985 MD Medicine and Surgery School of Medicine; University of Valencia, Spain 1986 MD Excellence Award School of Medicine; University of Valencia, Spain 1987 PhD Medicine and Surgery School of Medicine; University of Valencia, Spain 1991 Board Certified in Ob/Gyn University Clinic Hospital; University of Valencia, Spain 2005 – Present Académico Correspondiente Royal Academy of Medicine; Valencia Current Professor of Obstetrics and Gynecology, University of Valencia. Spain (since 2007) Department Appointments Obs/Gyn Adjunct Clinical Professor of Obstetrics and Gynecology, Stanford University. USA (since 2013). Department Obs/Gyn - REI Adjunct Professor of Obstetrics and Gynecology, Baylor College of Medicine. USA (since 2014) Scientific Director, Instituto Valenciano de Infertilidad (IVI), Valencia. Spain (1994 - 2016) IVI Scientific Director, Fundación IVI, Valencia. Spain (1994 - 2016) Fundacion IVI Founder & Scientific Director, Igenomix SL. Biotec company located in Valencia (Spain) Miami, New York & Los Angeles (USA), Mexico City (Mexico), New Delhi (India), Sao Paulo (Brasil), Dubai (UAE), Montreal (Canada), Istanbul (Turkey) (since 2009), London (UK), Tokio (Japan) Igenomix
Fellowships 1983 Fellow in Obstetrics and Gynecology. Universität-Klinik of Mainz. Germany. 1991–1994 Research Fellowship in Reproductive Endocrinology. Stanford University. USA. Post-doctoral Grant from the Spanish Government. 1997 Fellow in Reproductive Endocrinology. Stanford University. USA Registration 1993 – Present College of Physicians of Valencia. Spain (#464612993) COMV 2005 – Present Royal Academy of Medicine; Valencia, Spain. RAMCV Visiting 1997 University of Adelaide (Australia) Professorships 2006 The University of Hong Kong (Hong Kong) 2007 Yale University (USA)
3 Affiliations, • American Society for Reproductive Medicine (ASRM) Member Societies • European Society of Human Reproduction and Embryology (ESHRE) • Society for Gynecologic Investigation (SGI) • European Federation of Immunology and Reproduction (EFIR). • Preimplantation Genetic Diagnosis International Society (PGDIS) • International Society for Immunology of Reproduction (ISIR) • American Association for the Advancement of Science (AAAS) • American Society for Reproductive Immunology (ASRI) • New York Academy of Sciences (NYAS) • American Society for Cell Biology (ASCB) • International Federation of Fertility Societies (IFFS) • International Society for Stem Cell Research (ISSCR) • Spanish Fertility Society (SEF) • Spanish Obstetrics and Ginecology Society (SEGO) • International Federation of Cervical Patology and Colposcopy (IFCPC) • Colombian Asociation of Fertility and Sterility (ACFE) • Member of the Evaluation Board for the Diabetes & Endocrinology Faculty of Faculty of 1000 Medicine • Argentinean Society of Sterility and Fertility (SAEF) Board 2012 – 2016 Member of the Strategic Advisory Board of the Department of Development Membership and Regeneration, Katholieke Universiteit Leuven (Belgium) 2007 – 2011 Member of the Steering Committee and Scientific Advisory Board, European Human Embryonic Stem Cells Registry (Germany) 2009 – 2016 Board of Equipo IVI 2012 – present Board of Igenomix National 2006 – 2011 Member of the National Stem Cell Bank Committee, Ministry of Health, Spanish Research Government (Spain) Committees 2004 – 2005 Member of the Working Group for the Spanish Biomedicine Research Law, Ministry of Health, Spanish Government (Spain) 2006 Secretary of the National Faculty Selection Committee, Ministry of Education and Science, Spanish Government. Call 2/645/2006V. Spain
4 Scholarships and 2016 American Society for Reproductive Medicine (ASRM). Distinguished Research Award. Awards 2016 Society for Reproductive Endocrinology and Infertility (SREI). Prize Paper. 2016 Society for Reproductive Investigation (SRI). Pfizer-SRI President's Presenter's Award. 63rd Annual Meeting, Montreal (Canada) (2 awards). Trainees Director 2015 Salud 2000 Foundation Award. Madrid (Spain) 2015 Society for Reproductive Investigation (SRI). New Investigator Plenary Session Award. 62nd Annual Meeting, San Francisco (USA) 2015 Society for Reproductive Investigation (SRI), Best New Investigator Poster Award. 62nd Annual Meeting, San Francisco (USA) 2014 American Society for Reproductive Medicine (ASRM). KY Cha Award in Stem Cell Technology. Honolulu (USA) 2014 Society for Reproductive Investigation (SRI), President’s Presenter Award. 61st Annual Meeting, Florence (Italy) 2012 European Society of Human Reproduction and Embryology (ESHRE). Basic Science Oral Presentation Award. 28th Annual Meeting, Istanbul (Turkey) 2011 Prize Rey Jaime I in Medical Investigation. Valencia (Spain) 2011 Serono Symposia International Foundation (SSIF) Award. Rewarding Scientific Excellence in Medical Education. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. Stockholm (Sweden) 2011 – 2016 American Society for Reproductive Medicine (ASRM). Star Award (USA) 2010 Salud 2000 Foundation Award. Madrid (Spain) 2009 Society for Gynecologic Investigation. President’s Presenter Award. 56 th Annual Meeting, Glasgow (Scotland) 2009 Merck Serono. Award for the Innovation, Quality & Image in Assisted Reproduction. Madrid (Spain) 2009 Lab Times, News Magazine for the European Life Science. 12 th Most Cited Author in Reproductive Biomedicine in Europe. Publication Analysis 1996-2007. http://www.labtimes.org/labtimes/ranking/2009_04/index.lasso 2008 American Society for Reproductive Medicine. Prize Paper Award. 64 th Annual Meeting, San Francisco, California (USA) 2008 Independent Bibliometric Analysis classifies Carlos Simon as the 9th Most Productive Author in Reproductive Biology in the World, (González-Alcaide G. et al., Fertil Steril 90:941-56, 2008). PMID 18177648 2006 Clinic Hospital Foundation Research Award. Valencia (Spain) 2005 American Society for Reproductive Medicine. Prize Poster Award. 61st Annual Meeting conjoint to 51st Annual Meeting of the Canadian Fertility and Andrology Society. Montreal (Canada) 2004 World Academy of Science, Technology, Education and Humanities Award. “Two First Stem Cells Lines in Spain”. Madrid (Spain) 2002 Society for Gynecologic Investigation. President’s Poster Award. 49 th Annual Meeting, Los Angeles, California (USA) 2002 Spanish Fertility Society. Prize Paper Award. XXIV Annual Meeting, Palma de Mallorca (Spain) 2001 American Society for Reproductive Medicine. Prize Paper Award. 57 th Annual Meeting, Orlando, Florida (USA) 2001 Salud 2000 Foundation Award. Madrid (Spain) 2000 Spanish Fertility Society. Prize Paper Award. XXIII Annual Meeting, Sevilla (Spain) 1999 American Society for Reproductive Medicine. Prize Paper Award. 55th Annual Meeting conjoint to 45th Annual Meeting of the Canadian Fertility and Andrology Society, Toronto (Canada)
5 1999 Salud 2000 Foundation Award. Madrid (Spain) 1999 Spanish Obstetrics and Gynecology Society Award. XXV Annual Meeting, Zaragoza (Spain) 1999 Spanish Obstetrics and Gynecology Society. 3 rd Best Video Award. XXV Annual Meeting, Zaragoza (Spain) 1997 American Society for Reproductive Medicine. Prize Paper Award. 53th Annual Meeting, Cincinnati, Ohio (USA) 1997 Organon Award for the Best Poster In Contraception. XXV Annual Congress of the Spanish Obstetrics and Gynecology Society, Zaragoza (Spain) 1997 Medical College of Lugo Award. Most Innovative Video. V National Congres in Obstetrics and Gynecology Videos, Lugo (Spain) 1996 Salud 2000 Foundation Award. Madrid (Spain) 1995 American Society for Reproductive Medicine. Prize Paper Award. 51th Annual Meeting, Seattle, Washington (USA) 1995 Valencian Obstetrics and Gynecology Society. Vicente Zaragozá Orts Award. Valencia (Spain) 1993 American Society for Reproductive Medicine. Prize Paper Award. 49th Annual Meeting, Montreal (Canada) 1993 Society for Gynecologic Investigation. President’s Poster Award. 40th Meeting, Toronto (Canada) 1992 Spanish Fertility Society. José A Portuondo Award. XVIII Annual Meeting, XIX Annual Meeting, Alicante (Spain) 1986 School of Medicine, University of Valencia. M.D. Degree Excellence Award. Valencia (Spain) 1984 School of Medicine, University of Valencia. López Sancho Award in Obstetrics and Gynecology. Valencia (Spain)
6 Previous 2009 – 2012 President, BIOVAL (The Valencian Biotech Region) Valencia, Spain Appointments 2009 – 2011 Scientific Director, Prince Felipe Research Center. Valencia, Spain. 2005 – 2007 Coordinator, Department of Regenerative Medicine; Prince Felipe Research Center. Valencia, Spain. 2004 – 2011 Director, Valencia Stem Cell Bank; Prince Felipe Research Center. Valencia, Spain. Valencia Node of the Spanish National Bank of Stem Cells, Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spanish Government. 1999 – 2002 Secretary, Department of Obstetrics and Gynecology, University of Valencia (Spain) 1994 – 2007 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, University of Valencia. Valencia, Spain. 1991 – 1994 Fellowship in Reproductive Endocrinology, Dept of Ob/Gyn, Stanford University, USA 1991 Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, University of Valencia. Valencia, Spain. 1987 – 1991 Resident in Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University Clinic Hospital of Valencia / University of Valencia, Spain. 1987 – 1990 Assistant Professor in Obtetrics, Gynecology and Breast Ultrasound, Department of Obstetrics and Gynecology, University Clinic Hospital of Valencia. University of Valencia, Spain. 1986 – 1987 Assistant Professor, College of Midwives, Clinic University Hospital. Spain 1983 – 1985 Undergraduate Mentor, Department of Obstetrics and Gynecology, School of Medicine, University of Valencia. Valencia, Spain. Current University of Valencia. INCLIVA, Spain. Institutional Stanford University. CA, USA. Affiliation Baylor College of Medicine. TX, USA. Igenomix SL. Valencia, Spain (Headquaters)
7 Committees and 2017 – present Chair-Elect, Regenerative Medicine and Stem Cell Biology Special Interest Group Leadership (RMSCBSIG) American Society for Reproductive Medicine (ASRM) 2016 Member of European Commission Scientific Committee 2015 NIH Endometrium, Placenta, Implantation Research Focus Group (EPI RFG) (USA) 2013 – present Committee Member for the KY Cha Award in Stem Cell Technology, American Society for Reproductive Medicine (USA) 2011 – present Member of the Advisory Committee, Serono Symposia International Foundation (SSIF) (Switzerland) 2009 – 2012 President of Valencia Biotech Region of Biotechnology Companies (BIOVAL) (Spain) 2009 – 2011 Coordinator of the Special Interest Group in Stem Cells, European Society of Human Reproduction and Embryology (ESHRE) (Belgium) 2009 Member of the Faculty Selection Committee, University of Valencia (Spain) 2008 – 2015 Executive Committee, International Society of Gynecological Endocrinolgy (Italy) 2008 Member of the Educational Committee, Society for Gynecologic Investigation (SGI) (USA) 2008 Scientific Committee of Honor of the Gynecological Endocrinology Latin-American Association (ALEG) (Argentina) 2007 – 2017 Member of the International Advisory Committee. American Society for Reproductive Medicine (ASRM) 2007 – 2009 Deputy of the Special Interest Group in Stem Cells, European Society of Human Reproduction and Embryology (ESHRE) (Belgium) 2006 – 2011 Member of the National Stem Cell Bank Committee, Ministry of Health, Spanish Government (Spain) 2006 – present Member of the Committee on Bioethics, University of Valencia (Spain) 2006 – 2008 Member of the International committee International Society for Stem Cell Research (ISSCR) (USA) 2005 – 2007 Coordinator of Regenerative Medicine Working Group, Spanish Nanomedicine Platform (Spain) 2004 – 2007 Member of the International Scientific Committee of the International Federation of Fertility Societies (IFFS) (USA) 2004 – 2006 Secretary of Spanish Fertility Society (Spain) 2004 – 2005 President, Reproductive Inmunology Special Interest Group (RISIG) American Society for Reproductive Medicine (ASRM) (USA) 2002 – 2004 Treasurer of Spanish Fertility Society (Spain) 2002 – 2003 Deputy of the Endometriosis/Endometrium Special Interest Group, European Society of Human Reproduction and Embryology (ESHRE) (Belgium) 2002 – 2003 Secretary / Treasurer. Reproductive Inmunology Special Interest Group (RISIG) American Society for Reproductive Medicine (ASRM) (USA) 2001 Member of Award Committee, Fundación SALUD 2000 (Spain) 2000 – 2002 Spanish Representative in the Advisory Committee of European Society of Human Reproduction and Embryology (ESHRE) (Belgium) 1999 – present Member of the Scientific Committee, University of Valencia (Spain) 1997 – 2007 International Committee Society of Gynecological Investigation (USA) 1995 – 2004 Member Research Commission Department of Obstetrics and Gynecology, University of Valencia (Spain)
8 Peer Review 2001 – present Scientific Reviewer of the Health Research, Charity for Women and Babies Granting Bodies (WELLBEING) (UK) 2000 – present Scientific Reviewer National Health and Medical Research Council (NHMRC) (Australia) 1997 – present Scientific Reviewer of The Wellcome Trust Foundation (UK) 2008 Scientific Reviewer of The Research Foundation Flanders (FWO) (Belgium) 2008 Scientific Reviewer of the The Estonian Science Foundation (ETF) (Estonia) 2007 Scientific Reviewer of the UK Stem Cells Foundation (UK) 2006 Scientific Reviewer of the Association Française contre les Myopathies (France) 2005 Scientific Reviewer of the Fundación Victor Grífols i Lucas (Spain) 2004 Scientific Reviewer of The Israel Science Foundation (ISF) (Israel) 2003 Scientific Project Advisor, University of California San Francisco (USA) 2002 Scientific Reviewer Fundación Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Spanish Govermment (Spain) 2001 Scientific Reviewer of the Health Research Board in Ireland (UK) 1997 John Guggenheim Memorial Foundation (USA) 1995 –1997 & 2009 German-Israeli Foundation for Scientific Research & Development (Israel)
Involvement in Professional Societies – Membership Scientific 2014 – 2019 Research Task Force, American Society for Reproductive Medicine (ASRM) Disciplines 2013 SGI New Investigator Advisory Group, Society for Gynecologic Investigation (USA) 2009 – present Scientific Reviewer. Endometriosis Association of Spain (Spain) 2007 Member of the Task Force of Clinical Trials, International Society for Stem Cell Research (USA) 2006 – present Member of the Stem Cells Special Interest Group (ESHRE) (Belgium) 2001 – 2003 External International Advisor of Organon International (The Netherlands) 1998 – 2000 Consultant of Merck Serono SA (Switzerland) 1997 – 2007 Member of the Expert Advisory Panel on Reproductive Medicine, International Federation of Gynecology & Obstetrics (FIGO) UK
9 Panel of Referees Referee for grants from: for Granting 2015 Expert Referee to assess the Health System in Reproductive Medicine in Kuwait Bodies 1998 – 2014 Member of the Human Reproduction Program. Advisor of the Scientific and Ethical Review Group, World Health Organization (Switzerland) 1999 – present National Agency of Evaluation and Prospective (ANEP), Spanish Government (Spain) 2002 – present Research Project Referee, Instituto de Salud Carlos III, Spanish Government (Spain) th 2002 – 2006 Expert Referee of 6 Framework Program, European Commission (Belgium) 2008 – present Member of the Expert Panel, ACADEMIA Program for the National Accreditation, National Agency for Quality Assessment and Accreditation (ANECA). Spanish Government (Spain) 2008 Member of the Scientific Advisory Committee, Valencian Agency of Agency of Evaluation and Prospective (AVAP). Valencian Govermment (Spain) 2007 Member of the Advisory Committee, Institute for Small and Medium Industry of the Generalitat Valenciana (IMPIVA) (Spain) 2007 Referee for Projects of Excellence, Ministy of Innovation and Science, Andalusian Agency of University Quality Evaluation Acreditation (Spain) 2006 Research Project Referee, Colombian Institute for the Development of Science and Technology (Colombia) 2006, 2007, 2014 Royan International Research Award, Teheran, Iran
10 Panel of Referees for Professional Editor: Journals ••• Fertility and Sterilily (2016-present) Editorial Editor ••• Fertility and Sterilily (2011-2016) Associate Editor ••• Human Reproduction (2001-2007) Former Associate Editor
Editorial Boards of International Journals ••• Frontiers in bioscience (since 1995) ••• Journal of Reproductive Immunology (since 1997) ••• American Journal of Reproductive Immunology (1997-2006) ••• Gynecological Endocrinology (since 1997) ••• Reproductive Sciences formerly known as the Journal of the Society for Gynecologic Investigation (since 2000) ••• Gynecologic and Obstetric Investigation (2001-2004) ••• Reproduction (2002-2007) ••• European Journal of Endocrinology (2001-2004) ••• Reproductive Biomedicine Online (since 2004) ••• Regenerative Medicine (since 2006). ••• Journal of Endometriosis (since 2008) ••• Clinical and experimental reproductive medicine (CERM) (since 2011) ••• ISRN Obstetrics and Gynecology (since 2013) ••• Journal of Reproductive Health and Medicine (since 2014)
Editorial Boards of National Journals
• Secretary and Member of the Editorial Board, Revista Iberoamericana de Fertilidad y Reproducción Humana (since 2000) • Co-Editor, Cuadernos de Medicina Reproductiva (1995-2005) • Revista de Medicina Reproductiva, Centro de Estudios en Ginecología y Reproducción (CEGYR). Argentina. (1997) • Novedades Terapéuticas en Reproducción Humana (Excerpta Medica, España). • Reproducción Humana. Revista de la Federación Latinoamericana de Sociedades de Esterilidad y Fertilidad (F.L.A.S.E.F) since 2001 • Medicina Reproductiva (Colombia) since 1998 • Actualizaciones de la Sociedad Española de Fertilidad 2000 (SEF) • Miembro del Comité Científico del e-medicaljournal.net. sitio web para profesionales de la medicina (Buenos Aires) • Obstetricia y Ginecología de Postgrado. Universidad de Valencia. Since 2003 • Prgresos de Obstetricia y Ginecología. Revista oficial de la Sociedad Española de Obstetricia y Ginecología.
AD HOC Reviewer for International Journals
• Nature Reviews Endocrinology (2016) • Nature Medicine (since 2011) • The Lancet (since 2007) • Proceeding of the National Academy of Science (since 2007) • Stem Cells (since 2007) • Stem Cells and Development (since 2007) • FASEB Journal, Federation of American Societies for Experimental Biology (since 2006) • Oncogene (since 2011) • Journal of Clinical Endocrinology and Metabolism (since 2000) • Human Reproduction Update (since 1998)
11 • Endocrinology (since 2000) • Human Reproduction (since 1995) • Molecular Human Reproduction (since 1996) • Human Molecular Genetics (since 2011) • Fertility and Sterility (since 1999) • Biology of Reproduction (since1994) • Reproductive Sciences formerly known as the Journal of the Society for Gynecologic Investigation (since 2007) • Plos One (Since 2014) • Placenta (Since 2014) • Journal of Reproductive Immunology (since 2002) • International Journal of Gynecology and Obstetrics. Official publication of the International Federation of Gynecology and Obstetrics (FIGO) (since 2004) • American Journal of Obstetrics and Gynecology (2003) • Annals of Biomedical Engineering (since 2002) • Asian Journal of Andrology (since 2002) • Cells Tissues Organs (since 2003) • Clinical Endocrinology (since 2001) • European Journal of Biochemistry (since1998) • European Journal of Obstetrics & Gynecology and Reproductive Biology (since 2000) • Journal of Cellular and Molecular Medicine (since 2006) • Journal of Endocrinological Investigation (since 1997) • Journal of Reproduction and Fertility/Reproduction (since 2000) • NEOPLASIA. An International Journal for Oncology Research (since 2001) • Journal of Assisted Reproduction and Genetics (since 2007) • Rejuvenation Research (since 2007) • Free Radical Biology and Medicine (since 2015) • Molecular and Cellular Endocrinology (since 2015)
12 Previous, and Since 1991, I have contributed pioneering work in the study of human endometrial receptivity (Ruiz- current research Alonso M et al., Biochim Biophys Acta 2012 PMID: 22634130 ), embryo development and viability experience (Thouas et al., Endocr Rev 2015 PMID: 25548832 ), and the cross-communication between them (Vilella F, et al Development. 2015 PMID: 26395145 ), as well as the mechanisms that regulate human embryonic implantation (Cha J, Vilella F, Dey SK and Simón C. Science 2013, pp. [44-48] Science ). I discovered the functional relevance of the interleukin-1 system in endometrial receptivity regulation and human embryonic implantation (Simon et al., Endocrinology 1994 PMID: 8299552 ) and demonstrated the deleterious effect of high levels of estradiol on endometrial receptivity in patients with high response to gonadotrophins, modifying established clinical practice and initiating the concept of mild stimulation (Simon et al., Human Reprod 1995 PMID: 8530680 ). Using the human endometrial side population in a xenograft murine model, my lab demonstrated the existence and the functional proof of concept of human endometrial stem cells (Cervello et al., PlosOne 2010, 2011, 2012 PMID: 20585575 ; PMID: 21712999 ; PMID: 22276168 ) that now are ready for clinical translation with the promise to restore endometrium in women suffering from Asherman síndrome and atrophic endometrium (Human Reprod 1–10, 2016 doi:10.1093). Using microarray technology, I discovered the transcriptomic signature of human endometrial receptivity, publishing our findings in 20 works as first or last author (Diaz-Gimeno et al., Fertil Steril 2011 PMID: 20619403 ), one of them is the 2 nd most cited article in the journal Molecular Human Reproduction (Riesewijk et al, Mol Hum Rep 2003 PMID: 12728018 ). Clinical translation of this work resulted in a patent for the creation of a customized endometrial receptivity array (ERA) EP2333107A1 for the molecular diagnosis of endometrial receptivity in infertile patients, the creation of a biotech company ( www.igenomix.com ) and I have produced a free on line human endometrial gene expression database (www.endometrialdatabase.com ) managed by University of Valencia. In an independent bibliometric analysis of publications in Reproductive Biology between 2003 and 2005, I was identified as the ninth most productive scientist in the world (Gonzalez-Alcaide et al., Fertil Steril 2008 PMID 18177648 ). Since 2001, my work in human embryology allowed me to expand my research into the field of stem cells, resulting in the derivation, characterization, and registration in the National Stem Cell Bank (BNLC) of ten human embryonic stem cell lines (VAL-3,4,5,6M,7,8,9,9 /Oct-4, 10B & 11B hESCs ). I pioneered the first derivation of embryonic stem cell lines in Spain and described a new system for freezing these cells in the absence of animal contaminants. I derived VAL-6M, the first Spanish line with a monogenic disorder (Myotonic Dystrophy Type I VAL-6M ) used as disease model by other researchers. I participated with the VAL lines in a collaborative study demonstrating the lack of genetic diversity in the most common used cell lines in the world (Mosher JT et al. N Engl J Med 2009 PMID: 20018958 ). My pioneering work in this field made possible the creation of the Valencia Node of the Spanish Stem Cell Bank in 2004, located in the Prince Felipe Research Center and from September 2009 to September 2011 I was Scientific Director of this Research Center. My lab has been working on the generation of artificial gametes using direct reprograming with 6 germ line- related factors in human somatic cells (Medrano JV, et al., Scientific Reports 2016). Recently, we have created a prediction model for aneuploidy in early human embryo development revealed by single cell analysis. (Vera-Rodriguez et al., Nat Commun. 2015 PMCID: PMC4506544 ), together with the impact of mitochondrial DNA content as a viability score in human euploid embryos (Diez-Juan A , et al., Fertil Steril 2015 PMID: 26051102 ), and my opinion on this topic has been considered in Cell Stem Cell (Diez-Juan A & Simón C. Cell Stem Cell 2015 PMID: 25957899 ).
13 Research • Human Endometrial Receptivity interests • Human Embryology • Embryonic Implantation • Endometrium • Epigenetics and Reproduction • Endometrial and Myometrial Stem Cells • Testicular Stem Cells • Endometriosis • Reprograming • Biomarkers in Reproductive Medicine Patents • Simón C . Non-invasive preimplantation genetic analysis and related methods. Ref: 62/301,825. Owner: Igenomix SL • Simón C , Medrano JV, Pellcer A. Direct conversion of human somatic cells to meiotic germ-like cells by genetics reprogramming. Ref: 62/048,493. Owner: Equipo IVI Investigación. • Simón C , Santamaría X, Cervelló I, Pellicer A. Stem cell theraphy in endometrial pathologies. Ref: PCT/IB2015/001715. Owner: Igenomix SL • Simón C , Garrido-Gómez T, Pellicer A. Early detection of preeclampsia. Ref: PCT/US2015/021495. Owner: Igenomix SL • Simón C , Horcajadas JA, Diaz-Gimeno P, Pellicer A. Gene Expression profile as an endometrial receptivity marker. Ref: PCT/ES2009/000386. Owner: Igenomix SL • Simón C , Pellicer A, Berlanga O. Diagnostic method for endometrial receptivity. Ref: PCT/EP2011/050867. Owner: Igenomix SL. • Sánchez Madrid F, Yañez Mo M, Domínguez F, Simón C . Use of CD98 as endometrial receptivity marker. Ref: PCT/ES2010/070744. Owner: Fundación IVI, UAMD - Universidad Autónoma de Madrid / CNIC - Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III • Pellicer A, Simón C , Gómez R. The use of dopamine agonist to prevent ovarian hyperstimulation. Ref: PCT/IB2006/000989. Owner: Fundación Instituto Valenciano de Infertilidad, sold to Ferring S.A. • Pellicer A, Simón C , Novella E. The use of dopamine agonist to treat endometriosis. Ref: PCT/IB2008/001273. Owner: Fundación Instituto Valenciano de Infertilidad, sold to Ferring S.A. • Simón C , Blesa D, Pellicer A. Massive failure Diagnosis of the mature oocyte generation in controlled ovarian stimulation treatments. Ref: EP12382032.6. Owner: Igenomix SL. • Simón C , Ruiz-Vela A, Aguilar-Gallardo C. Methods for tumor treatment and adipogenesis differentiation. Ref: PCT/EP2011/004941. Owner: Centro de Investigación Príncipe Felipe. • Krtolica A, Simón C , Foulk R. Methods and compositions relating to embryonic stem cell lines. Ref: PCT/US2005/046953. Owner: StemLifeLine, Inc. • Krtolica A, Simón C , Foulk R. Methods and systems relating to embryonic stem cell lines. Ref: PCT/US2005/047178. Owner: StemLifeLine, Inc. • Polan ML, Simón C . Methods of contraception. Ref: PCT/US1994/011588. Owner: Personal. • Escribá MJ, Simón C , Pellicer A. Method of producing cell lines. Ref: PCT/ES2002/000116. Owner: Fundación IVI. Commercial The technological impact of my clinical research originated 14 international Patent Applications, as translation of inventor or co-inventor, leading to the creation of a Biotech Company in the field of Genomics in research Reproductive Medicine Igenomix SL. http://www.igenomix.com with operations in Valencia (Spain) Miami, New York & Los Angeles (USA), Mexico City (Mexico), New Delhi (India), Sao Paulo (Brasil), Dubai (UAE), Montreal (Canada), Istanbul (Turkey), London (UK), Tokyo (Japan), Rome (Italy) Igenomix
2012-2015 Scientific Advisory Board of Ovascience (Boston) 2005-2007 Scientific Advisory Board of Anecova S.A. (Switzerland)
14 Governmental Grants Held as PI
Grant Title of Project Amount ($)
2016
BFU2015-72131-EXP Cryptochromes, the inexplicable presence of light sensors in the 60,000 € darkness conecting early embryo with the cosmos Spanish Ministry of 3 years Economy and Competitivity
SAF2015-67154-R Maternal Transcriptomic Regulation of the Pre-implantation Embryo. A 169,400 € novel mechanism to understand the origin of adult diseases such as Spanish Ministry of obesity and/or related to tobacco exposure 3 years Economy and Competitivity
2015
2R01HD032067-19 Bone Morphogenic Protein Signaling Pathways In Uterine Biology. 328,888 USD
National Institutes of Health PI of sub-project 2 1 year Grant (NIH) . USA
2014
PTQ-13-06133 Endometrial microbiome analysis, diagnosis and treatment using 69,300 € probiotics to improve endometrial receptivity in infertile patients. Spanish Ministry of 4 years Economy and Competitiveness
2013
PTQ-12-05320 Critical studies for the acquisition of new knowledge to improve the 85,000 € diagnosis service “Endometrial Receptivity Array” (ERA) Spanish Ministry of 3 years Economy and Competitiveness
SARM 324509 Endometrial and Embryonic Genomics, Searching for Biomarkers in 668,759.63 € Assisted Reproduction. FP 7. Marie Curie 4 years Program. European Commission
PROMETEOII/2013/018 Specific identification markers of endometrial somatic stem cells. 287,000 € From animal models to cell therapy. Conselleria d’Educació, 4 years Generalitat Valenciana.
2012
15 Etorgai ER-2012/00020 NEOBIO: New products for reproductive and prenatal health 280,601 €
Basque Government, 3 years Spain
SAF2012-31017 Demostration of Leucine-Rich Repeat-Containing G-Protein Coupled 120,000 € Receptor 5 (Lgr5) as an Endometrial Stem Cell Marker. From Animal Spanish Ministry of Models to Human Endometrial Stem Cell Therapy and Tissue 3 years Economy and Engineering. Competitivity
EC11-299 New Strategies in the Therapeutics of Asherman’s Syndrome and 91,707 € Endometrial Atrophy Based in the Autologous Tranplantations of Bone Spanish Ministry of Health Marrow Stem Cells. 2 years
2011
E!6478-NOTED Non-invasive Tests for Endometrial Dysfunction – Novel Clinical 159,082 € Perspectives for Infertility and Endometriosis Diagnostics. Eurostars-Eureka 4 years Programme, European Comission.
2010
FI 10/00813 Role of IMPL-1 Receptor and its Ligand in Embryo Implantation. 85,200 €
Carlos III Health Institute, 5 years Spanish Ministry of Health
(Mentoring PhD Student)
2009
SAF2008-02048 Isolation and characterization of endometrial somatic stem cells in 175,450 € endometriosis. Pathogenic and therapeutic implications Spanish Ministry of 3 years Science and Innovation
AECI. A/018463/08 Localization, isolation and characterization of somatic stem cells in 20,000 € myomas. Spanish Ministry of 1 year Foreign Affairs and Cooperation
RD09/0076/00063 Biobank network. RETICS 5,750 €
Spanish Ministry of Health 4 years
2008
PROMETEO/2008/163 Isolation and characterization of endometrial somatic stem cells in 703,250 € endometriosis. Pathogenic and therapeutic implications. Conselleria d’Educació, 6 years Generalitat Valenciana.
16 Etorgai. IEI08-003 Biomics - Personalized medicine applied to the clinical diagnosis 238,179 €
Basque Government, 3 years Spain
2007
RD06/0010/1006 Cell Therapy Network 276,067.05 €
Spanish Ministry of Health 6 years
2005
FP6-2005- European human embryonic stem cell registry 1,000,000 € LIFESCIHEALTH-6, proposal nº 037820 – EU Chief Investigator: Joeri Borstlap 3 years hESC registry.
European Commission, Research Directorate General, Programme: “Integrating and strengthening the European Research Area”
2004
SAF2004-00204 Identification, Characterization and Isolation of Adult Stem Cells in the 81,750 € Human Endometrium. Endometrial Implications and Endometrial Spanish Ministry of Cancer. 4 years Science and Technology
2003
PI021169 Study of Gene and Functional Expression of the Leptin System in the 67,850 € Human Endometrium Related with Obesity and Infertility Spanish Ministry of Health. 3 years
GRUPOS03/043 Genomics and Proteomics of Human Reproduccion. Grants for R&D 45,509.51 € Groups Agència Valenciana de 3 years Ciencia i Tecnología. Generalitat Valenciana
SAF2002-11085-E “Molecular mechanisms of embryo implantation” Grant for the Project 18,000 € Submission to the European Commission. Grant to prepare the Spanish Ministry of coordination of an European Network. 1 year Science and Technology
2002
CIG-02-85 Paan-AG as a Contraceptive Target in Baboon 49,200 $
Program for Contraceptive 2 years Research & Development. CONRAD
2001
17 SAF2001-2948 Gene and Functional Study of the Human Endometrial Receptivity 109,973.19 €
Spanish Ministry of 4 years Science and Technology
2000
FIS 00/0643 Induction of Apoptosis in the Endometrial Epithelium as a Key 64,623.83 € Mechanism of Embryo Implantation Spanish Ministry of Health 3 years
1998
FIS 98/0855 Embryo Effect of the Integrins α1, α2, β3 y αvβ3 Regulation in the 71,069.68 € Human Endometrial 3 years
1996
FIS 96/1263 Production of Interleukin-1P, IL-1P and IL-1 Antagonist Receptor by 48,982.49 € Human Embryo Cocultured with Endometrial Cells as Potential Spanish Ministry of Health Marker in Endometrial Implantation 3 years
FONDECYT n. 1961175 Autocrine-Paracrine Steroid Syntesis Regulation in the Normal 17,429.35 € Spanish Ministry of Corpus Luteum and Patients with Endomtetriosis. The Role of the Education and Science. Cytokines 4 years Latin America Cooperation Program
1995
FIS 95/1352 Role of Interleukin-1 System in Human Implantation: the Antagonist 49,583.50 € Receptor as Potential Marker in Endometrial Implantation Spanish Ministry of Health 3 years
1994
931614. Interleukin-1 in Human Implantation. 22,748 $
NATO International 2 years Scientific Exchange Programmes
Grants from Scientific Societies and Pharma Companies Held as PI
Grant Title of Project Amount ($)
2014
KY Cha Award in Stem Direct conversion of human somatic cells to meiotic germ-like cells by 20,000 USD Cell Technology genetic reprogarmming. 3 years American Society for Reproductive Medicine
2013
18 Grant for Fertility Analysis of miRNAs in endometrial fluid as a tool for noninvasive 239,600 € Innovation (GFI) diagnosis of endometrial receptivity EMD Serono Research 2 years Institute, Inc.
2010
Grant for Fertility A Non-Invasive Diagnostic Method of Human Endometrial Receptivity 329,600 € Innovation (GFI) Status Based on a Specific Lipidomic Profiling in Endometrial Fluid 3 years EMD Serono Research Institute, Inc.
Gent per Gent Foundation Characterization of Neoplastic Stem Cells in Endometrial Cancer. 54,418 € 08/09 Pathogenic, Pronostic and Therapeutic implications. 3 years
2004
PR 3034 Prevention of premature LH-surge and enhancement of implantation 363,960 € rate by combined treatment with recombinant LH and a high dose PANTARHEI GnRH antagonist. 1 year BIOSCIENCE B.V.
Schering AG Project New gene targets for female interception and the adhesion model for 150,000 € screening compounds. 2 years
Bertarelli Foundation Proteomic pattern secreted by viable blastocyst as a diagnostic tool to 67,960 € Project accomplish single births after IVF. 3 years
ANECOVA SA. Development of an intrauterine device system TM using the 18,000 € encapsulation technology for assisted in vivo culture of male and female gametes or preimplantatory embryos in mammalian species. 1 year
2003
IMP-24070 Multicenter, randomized, doble-blind Pilot Study, Placebo-Controlled 63,000 € to compare the efficacy and safety of r-hLIF (emfilermina) to improve MERCK SERONO embryo implantation after In-Vitro Fertilization and Embryo Transfer in 2 years women with recurrente implantation Failure
2002
N. V. ORGANON Effect of IVF treatment on regulation of endometrial receptivity genes 16,666 $ in time. 1 year
2001
N. V. ORGANON Embryonic and hormonal gene regulation of human endometrial 16,666 $ epithelial cells. 2 years
N. V. ORGANON Differential effect of hCG, FSH and GnRH on the regulation of 16,666 $ endometrial receptivity gene expression in superovulated cycles 1 year
19 1999
N. V. ORGANON Regulation of endometrial receptivity in superovulated cycles with 41,400 $ gonadotrophins. 2 years
1998
N. V. ORGANON Feasibility study for the analysis of differential gene expression in 12,500 $ human endometrium biopsias. 1 year
20 21 Publications At ISI Web of Knowledge ( http://apps.isiknowledge.com ) Prof. Carlos Simon is author of 423 publications in international peer-review journals, adding up to an accumulated impact factor of 1,962.505 . His papers have received a total of 16,459 cites with an average of 39 cites/paper. His H- Index is 71. Updated Pubmed Publication List : http://www.ncbi.nlm.nih.gov/myncbi/simon_c
Peer Reviewed Articles in International Journals 2017 • Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C . Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology. Proc Natl Acad Sci U S A. 2017; 114(40):8468-77. • Salsano S, Quiñonero A, Pérez S, Garrido Gómez T, Simón C , Domínguez F. Dynamic expression of PGRMC1 and SERBP1 in human endometrium: an implication in the human decidualization process. Fertil Steril. 2017; 108(5):832-842.e1 • Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T, Kukushkina V, Saare M, Velthut-Meikas A, Krjustškov K, Aghajanova L, Lalitkumar PG, Gemzell-Danielsson K, Giudice L, Simón C , Salumets A. Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Sci Rep. 2017; 7(1):10077. • Díaz-Gimeno P, Ruiz-Alonso M, Sebastian-Leon P, Pellicer A, Valbuena D, Simón C . Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy. Fertil Steril. 2017; 108(4):703-710,e3 • Simón C . Introduction: To transfer or not transfer…a mosaic embryo, that is the question. Fertil Steril. 2017; 107(5):1083-1084. • Valbuena D, Valdes CT, Simón C . Introduction: Endometrial function: facts, urban legends, and an eye to the future. Fertil Steril. 2017; 108(1):4-8. • Valdes CT, Schutt A, Simón C . Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium. Fertil Steril. 2017; 108(1):15-18.033. • Rubio C, Bellver J, Rodrigo L, Castillón G, Guillén A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remohí J, Pellicer A, Simón C . In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017; 107(5):1122-1129. • Domínguez F, Ferrando M, Díaz-Gimeno P, Quintana F, Fernández G, Castells I, Simón C . Lipidomic profiling of endometrial fluid in women with ovarian endometriosis†. Biol Reprod. 2017; 96(4):772-779. • Simón C . Why should patients experience infertility or poor outcomes before using assisted reproductive technologies? Fertil Steril. 2017; 107(4):878-879. • Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C , Genbacev O, Fisher SJ. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. Development. 2017; 144(5):767-777. • Comstock IA, Diaz-Gimeno P, Cabanillas S, Bellver J, Sebastian-Leon P, Shah M, Schutt A, Valdes CT, Ruiz-Alonso M, Valbuena D, Simón C , Lathi RB. Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis. Fertil Steril. 2017; 107(3):740-748.e2. • Mas A, Stone L, O'Connor PM, Yang Q, Kleven D, Simón C , Walker CL, Al-Hendy A. Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis. Stem Cells. 2017; 35(3):666-678. • Ferrero H, Buigues A, Martínez J, Simón C , Pellicer A, Gómez R. A novel homologous model for noninvasive monitoring of endometriosis progression. Biol Reprod. 2017; 96(2):302-312. • Cervelló I, Gil-Sanchis C, Santamaría X, Faus A, Vallvé-Juanico J, Díaz-Gimeno P, Genolet O, Pellicer A, Simón C . Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche. Fertil Steril. 2017; 107(2):510-519.e3. • Campo H, Baptista PM, López-Pérez N, Faus A, Cervelló I, Simón C C. De- and recellularization of the pig uterus: a bioengineering pilot study. Biol Reprod. 2017; 96(1):34-45. • Mas A, Prusinski L, Yang Q, Diaz-Gimeno P, Stone L, Diamond MP, Simón C , Al-Hendy A. Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy.
22 Biol Reprod. 2017; 96(1):70-80. • Campo H, Cervelló I, Simón C . Bioengineering the Uterus: An Overview of Recent Advances and Future Perspectives in Reproductive Medicine. Ann Biomed Eng. 2017; 45(7):1710-1717 2016 • Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazán J, Alonso R, Alamá P, Remohí J, Pellicer A, Ramon D, Simón C . Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016 Dec;215(6):684-703. doi: 10.1016/j.ajog.2016.09.075. Epub 2016 Oct 4. PubMed PMID: 27717732. • Sanchez-Delgado M, Court F, Vidal E, Medrano J, Monteagudo-Sánchez A, Martin-Trujillo A, Tayama C, Iglesias-Platas I, Kondova I, Bontrop R, Poo-Llanillo ME, Marques-Bonet T, Nakabayashi K, Simón C , Monk D. Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting. PLoS Genet. 2016 Nov 11;12(11):e1006427. • Medrano JV, Rombaut C, Simón C , Pellicer A, Goossens E. Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions. Fertil Steril. 2016 Aug 1;PubMed PMID: 27490045. • Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munné S, Rienzi L, Rubio C, Scott K, Scott R, Simón C , Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch JR, Verpoest W, Wells D, Geraedts J. The why, the how and the when of PGS 20: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists. Mol Hum Reprod. 2016; 22(8):845-57. • Santamaria X, Katzorke N, Simón C . Endometrial 'scratching': what the data show. Curr Opin Obstet Gynecol. 2016; 28(4):242-9. • Strug MR, Su R, Young JE, Dodds WG, Shavell VI, Díaz-Gimeno P, Ruiz-Alonso M, Simón C , Lessey BA, Leach RE, Fazleabas AT. Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial. Hum Reprod. 2016; 31(7):1552-61. • Katzorke N, Vilella F, Ruiz M, Krüssel JS, Simón C . Diagnosis of Endometrial-Factor Infertility: Current Approaches and New Avenues for Research. Geburtshilfe Frauenheilkd. 2016; 76(6):699- 703. • Medrano JV, Martínez-Arroyo A, Miguez JM, Moreno-Gimeno I, Martinez S, Quiñonero A, Diaz- Gimeno P, Marques-Mari AI, Pellicer A, Remohi J, Simón C . Human somatic cells subjected to genetic reprogramming wiht 6 germ line-related factors display meiotic germ cell-like features. Scientific Reports. 2016; 6:24956. • Meldrum DR, Casper RF, Diez-Juan A, Simón C , Domar AD, Frydman R. Aging and the environment affect gamete and embryo potential: can we intervene? Fertil Steril. 2016; 105(3): 548-59 • Franasiak JM, Ruiz-Alonso M, Scott RT, Simón C . Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent normal birth in spite of a capable embryo. Fertil Steril. 2016; 105(4): 861-6. • Vera-Rodríguez M, Michel CE, Mercader A, Bladon AJ, Rodrigo L, Kokocinski F, Mateu E, Al- Asmar N, Blesa D, Simón C , Rubio C. Distribution patterns of segmental aneuploidies in human blastocysts identified by next-generation sequencing. Fertil Steril. 2016; 105(4): 1047-1055.e2. ••• García-Pascual CM, Ferrero H, Juarez I, Martínez J, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simón C , Gómez R, Pellicer A. Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma. Fertil Steril. 2016; 105(2): 529-38. • Santamaria X, Cabanillas S, Cervelló I, Arbona C, Raga F, Ferro J, Palmero J, Remohí J, Pellicer A, Simón C . Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. Hum Reprod. 2016; 31(5): 1087–1096. • Mir P, Mateu E, Mercader A, Herrer R, Rodrigo L, Vera M, Peinado V, Milán-Sánchez M, Campos-
23 Galindo I, García-Herrero S, Simón C , Rubio C. Confirmation rates of array-CGH in day-3 embryo and blastocyst biopsies for preimplantation genetic screening. J Assist Reprod Genet. 2016; 33(1): 59-66. • Galán A, Simón C . Monitoring Stemness in Long-Term hESC Cultures by Real-Time PCR. Methods Mol Biol. 2016; 1307: 89-104. 2015 • Vera-Rodriguez M, Chavez SL, Rubio C, Reijo Pera RA, Simón C . Prediction model for aneuploidy in early human embryo development revealed by single cell analysis. Nat Commun. 2015; 6:7601. • Simón C , Sakkas D, Gardner DK, Critchley HO. Biomarkers in reproductive medicine: the quest for new answers. Hum Reprod Update. 2015; 21(6): 695-7. • Thouas GA, Domínguez F, Green M, Vilella F, Simón C , Gardner DK. Soluble Ligands and their Receptors in Human Embryo Development and Implantation. Endocr Rev. 2015; 36(1): 92-130. • Diez-Juan A, Simón C . Converting a Problem into an Opportunity: mtDNA Heteroplasmy Shift. Cell Stem Cell. 2015 May 7; 16(5): 457-8. • Vilella F, Moreno-Moya JM, Balaguer N, Grasso A, Herrero M, Martínez S, Marcilla A, Simón C . Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome. Development. 2015; 142(18): 3210-21. • Gómez E, Ruíz-Alonso M, Miravet J, Simón C . Human Endometrial Transcriptomics: Implications for Embryonic Implantation. Cold Spring Harb Perspect Med. 2015; 5(7): a022996. • Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C , Laurent LC, Loring JF, Fisher SJ. Human stem cells from single blastomeres reveal pathways of Embryonic or trophoblast fate specification. Development. 2015; 142(23): 4010-25. • Galliano D, Bellver J, Díaz-García C, Simón C , Pellicer A. ART and uterine pathology: how relevant is the maternal side for implantation. Hum Reprod Update. 2015; 21(1): 13-38. • Martin J, Asan, Yi Y, Alberola T, Rodríguez-Iglesias B, Jiménez-Almazán J, Li Q, Du H, Alama P, Ruiz A, Bosch E, Garrido N, Simón C . Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology. Fertil Steril. 2015; 104(5): 1286-93. • García-Pascual CM, Martínez J, Calvo P, Ferrero H, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simón C , Pellicer A, Gómez R. Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis. Fertil Steril. 2015; 104(5): 1310-8. • Kawamura K, Cheng Y, Sun YP, Zhai J, Diaz-Garcia C, Simón C , Pellice A, Hsueh AJ. Ovary transplantation: to activate or not to activate. Hum Reprod. 2015; 30(11): 2457-60. • Vassena R, Eguizabal C, Heindryckx B, Sermon K, Simón C , van Pelt AMM, Veiga A, Zambelli F; on behalf of the ESHRE special interest group Stem Cells. Stem cells in reproductive medicine: ready for the patient? Hum Reprod. 2015; 30(9): 2014-21. • Garcia-Velasco JA, Fassbender A, Ruiz-Alonso M, Blesa D, D'Hooghe T, Simón C . Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study. Reprod Biomed Online. 2015; 31(5): 647-54. • Moreno JM, Núñez MJ, Quiñonero A, Martínez S, de la Orden M, Simón C , Pellicer A, Díaz- García C, Domínguez F. Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage. Fertil Steril. 2015; 104(4): 1037-1046.e1. • Rekker K, Saare M, Roost AM, Kaart T, Sõritsa D, Karro H, Sõritsa A, Simón C , Salumets A, Peters M. Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. Fertil Steril. 2015; 104(4): 938-946.e2.
24 • Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quiñonero A, Simón C . New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies. Fertil Steril. 2015; 104(4): 908-14. • Ferrero H, García-Pascual CM, Pellicer N, Simón C , Pellicer A, Gómez R. Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells. Reprod biol Endocrinol. 2015; 13(1): 104. • Cervelló I, Gil-Sanchis C, Santamaría X, Cabanillas S, Díaz A, Faus A, Pellicer A, Simón C . Human CD133 bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome. Fertil Steril. 2015; 104(6): 1552-1560.e3. • Cervelló I, Santamaría X, Miyazaki K, Maruyama T, Simón C . Cell Therapy and Tissue Engineering from and toward the Uterus. Semin Reprod Med. 2015; 33(5): 366-72. • Moreno I, Míguez-Forjan JM, Simón C . Artificial gametes from stem cells. Clin Exp Reprod Med. 2015; 42(2): 33-44. • Mas A, Nair S, Laknaur A, Simón C , Diamond MP, Al-Hendy A. Stro-1/CD44 asputative human myometrial and fibroid stem cell markers. Fertil Steril. 2015; 104(1): 225-34.e3. • Gil-Sanchis C, Cervelló I, Khurana S, Faus A, Verfaillie C, Simón C . Contribution of different bone marrow-derived cell types in endometrial regeneration using an irradiated murine model. Fertil Steril. 2015; 103(6): 1596-605. • Aleixandre-Benavent R, Simón C , Fauser BC. Trends in clinical reproductive medicine research: 10 years of growth. Fertil Steril. 2015; 104(1): 131-7.e5. • Diez-Juan A , Rubio C, Marin C, Martinez S, Al-Asmar N, Riboldi M, Díaz-Gimeno P, Valbuena D, Simón C . Mitochondrial DNA content as a viability score in human euploid embryos: Less is better. Fertil Steril. 2015; 1004(3): 534-541.e1. • Mas A, Cervelló I, Fernández-Álvarez A, Faus A, Díaz A, Burgués O, Casado M, Simón C . Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation. Mol Hum Reprod. 2015 Apr;21(4): 330-8. • Campos-Galindo I, García-Herrero S, Martínez-Conejero JA, Ferro J, Simón C , Rubio C. Molecular analysis of products of conception obtained by hysteroembryoscopy from infertile couples. J Assist Reprod Genet. 2015 May;32(5):839-48. • Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F, Simón C . Understanding and improving endometrial receptivity. Curr Opin Obstet Gynecol. 2015 Jun;27(3): 187-92. 2014 • Martínez-Arroyo AM, Medrano JV, Remohí J, Simón C . Germ line development: lessons learn from pluripotent stem cells. Curr Opin Genet Dev. 2014; 28C: 64-70. • Simón C , Bosch E, Bellver J. Endometrial scratching for women with repeated implantation failure. Hum Reprod. 2014; 29(8): 1618-21. • Garrido-Gómez T, Quiñonero A, Antúnez O, Díaz-Gimeno P, Bellver J, Simón C , Domínguez F. Deciphering the proteomic signature of human endometrial receptivity. Hum Reprod. 2014; 29(9): 1957-67. • Blesa D, Ruiz-Alonso M, Simón C . Clinical Management of Endometrial Receptivity. Semin Reprod Med. 2014; 32(5): 410-4. • Medrano JV, Martinez-Arroyo AM, Sukhwani M, Noguera I, Quiñonero A, Martinez-Jabaloyas JM, Pellicer A, Remohí J, Orwig KE, Simón C . Germ cell transplantation into mouse testes procedure. Fertil Steril. 2014; 102(4): e11-2. • Ferrero H, García-Pascual CM, Gaytán M, Morales C, Simón C , Gaytán F, Pellicer A, Gómez R. Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists. Fertil Steril. 2014; 102(5): 1468-76. • Nejat EJ, Ruiz-Alonso M, Simón C , Meier UT. Timing the window of implantation by nucleolar
25 channel system prevalence matches the accuracy of the endometrial receptivity array. Fertil Steril. 2014; 102(5): 1477-81. • Simón C . Introduction: Are we advancing in our scientific understanding and therapeutic improvement of uterine fibroids… or not? Fertil Steril. 2014; 102(3): 611-2. • Glasier AF, Gemzell-Danielsson K, Bouchard P, Genazzani A, Al-Azzawi F, Berga S, Birkhauser M, Brincat M, de Melo NR, Foidart JM, Kenemans P, Lunenfeld B, Maruo T, Milewicz A, Naftolin F, Ng EH, Schindler AE, Simón C , Simoncini T, Simpson E, Siseles N, Smetnik V, Tarlatzis BC, von Schoultz B. ISGE statement on oral emergency contraception. Gynecol Endocrinol. 2014; 30(10): 681-2. • Rodrigo L, Mateu E, Mercader A, Cobo AC, Peinado V, Milán M, Al-Asmar N, Campo- Galindo I, García-Herrero S, Mir P, Simón C , Rubio C. New tools for embryo selection: Comprehensive chromosome screening by array comparative genomic hybridization. BioMed Research International. 2014: 51712.Más A, Cervello I, Gil-Sanchís C, Simón C . Current understanding of somatic stem cells in leiomyoma formation. Fertil Steril. 2014; 102(3): 613-20. • Simón C , Bosch E, Bellver J. Endometrial scratching for women with repeated implantation failure. Reply. Hum Reprod. 2014; 29(12): 2856-7. • García-Pascual CM, Ferrero H, Zimmermann RC, Simón C , Pellicer A, Gómez R. Inhibition of Delta-like 4 mediated signaling induces abortion in mice due to deregulation of decidual angiogenesis. Placenta. 2014; 35(7): 501-8. • Medrano JV, Simón C , Pera RR. Human germ cell differentiation from pluripotent embryonic stem cells and induced pluripotent stem cells. Methods Mol Biol. 2014; 1154: 563-78. • García-Herrero S, Campos-Galindo I, Martínez-Conejero JA, Serra V, Olmo I, Lara C, Simón C , Rubio C. BACs-on-Beads Technology: A reliable test for rapid detection of aneuploidies and microdeletions in prenatal diagnosis. Biomed Res Int. 2014: 590298. • Ruiz-Alonso M, Galindo N, Pellicer A, Simón C . what a difference two days make: “personalized” embryo tranfer (pET) paradigm: a case report and pilot study. Hum Reprod. 2014; 29(6): 1244-7. • Bermejo A, Iglesias C, Ruiz-Alonso M, Blesa D, Simón C , Pellicer A, Gracía-Velasco J. The impact of using the combined oral contraceptive pill for cycle scheduling on gene expression related to endometrial receptivity. Hum Reprod. 2014; 19(6): 1271-8. • Moreno-Moya JM, Vilella F, Martínez S, Pellicer A, Simón C . The transcriptomic and proteomic effects of ectopic overexpression of miR-30d in human endometrial epithelial cells. Mol Hum Reprod. 2014; 20(6): 550-66. • Romanelli V, Nakabayashi K, Vizoso M, Moran S, Iglesias-Platas I, Sugahara N, Simón C , Hata K, Esteller M, Court F, Monk D. Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer. Epigenetics. 2014; 9(5): 783-90. • Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simón C , Moore H, Harness JV, Keirstead H, Sanchez-Mut JV, Kaneki E, Lapunzina P, Soejima H, Wake N, Esteller M, Ogata T, Hata K, Nakabayashi K, Monk D. Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Genome Res. 2014; 24(4): 554-69. • Ferrero H, García-Pascual CM, Gómez R, Delgado-Rosas F, Cauli O, Simón C , Gaytán F, Pellicer A. Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro: implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists. Fertil Steril. 2014;101(5):1411-18. • Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Simón C . Transcriptomics of the human endometrium. Int J Dev Biol. 2014; 58(2-3-4): 127-37. • Moreno-Moya JM, Vilella F, Simón C . MicroRNA: key gene expression regulators. Fertil Steril. 2014; 101(6): 1516-23. • Dominguez F, Moreno-Moya JM, Lozoya T, Romero-Espinos A, Martínez S, Monterde M, Gurrea M, Ferri B, Núñez MJ, Simón C , Pellicer A. Embryonic miRNA profiles of normal and ectopic pregnancies. PloS One. 2014; 9(7): 102185. • Moreno-Moya JM, Ramírez L, Vilella F, Martínez S, Quiñonero A, Noguera I, Pellicer A, Simón C . Complete method to obtain, culture, and transfer mouse blastocysts nonsurgically to study implantation and development. Fertil Steril. 2014 Mar;101(3):e13.
26 • Bermejo A, Cerrillo M, Ruiz-Alonso M, Blesa D, Simón C , Pellicer A, Garcia-Velasco JA. Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression. Fertil Steril. 2014 Jan;101(1):138-146.e3. • Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C , Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A. Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb;20(1):12-28. • Lozoya T, Dominguez F, Romero-Ruiz A, Steffani L, Martínez S, Monterde M, Ferri B, Núñez MJ, Romero-Espinos A, Zamora O, Gurrea M, Sangiao-Alvarellos S, Vega O, Simón C , Pellicer A, Tena-Sempere M. The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy. PloS One. 2014; 9(1):e87698 2013 • Cha J, Vilella F, Dey SK and Simón C . “Molecular Interplay in Successful Implantation” in Ten CriticalTopics in Reproductive Medicine, S. Sanders, Ed. ( Science/AAAS , Washington, DC, 2013), pp. [44-48]. • Vilella F, Ramirez L, Berlanga O, Martínez S, Alamá P, Meseguer M, Pellicer A, Simón C . PGE2 and PGF2 α concentrations in human endometrial fluid as biomarkers for embryonic implantation. J Clin Endocrinol Metab. 2013; 98(10): 4123-32. • Belmar-Lopez C, Mendoza G, Oberg D, Burnet J, Simón C , Cervello I, Iglesias M, Ramirez JC, Lopez-Larrubia P, Quintanilla M, Martin-Duque P. Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth. BMC Med. 2013; 28(11): 139. • García-Pascual CM, Zimmermann RC, Ferrero H, Shawber CJ, Kitajewski J, Simón C , Pellicer A, Gómez R. Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2-driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells. Fertil Steril. 2013; 100(6): 1768-76. • Simón C . Personalized ART. Fertil Steril. 2013; 100(4): 922-3. • Gil-Sanchis C, Cervello I, Más A, Faus A, Pellicer A, Simón C . Leucine-rich repeat-containing G- protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker. Mol Hum Reprod. 2013; 19(7): 407-14. • Vilella F, Ramirez LB, Simón C . Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril. 2013; 99(4): 1100-6. • Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C . Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril. 2013; 99(4): 1078-85. • Martín J, Cerveró A, Mir P, Martínez-Conejero JA, Simón C . The impact of next-generation sequencing technology on preimplantation genetic diagnosis and screening. Fertil Steril. 2013; 99(4): 1054-61. • Rubio C, Rodrigo L, Mir P, Mateu E, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, Garcia S, Simón C . Use of array comparative genomic hybridization (array-CGH) for embryo assessment: clinical results. Fertil Steril. 2013; 99(4): 1044-8. • Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, De Los Santos MJ, Giles J, Labarta E, Domingo J, Crespo J, Remohí J, Pellicer A, Simón C . Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertil Steril. 2013; 99(5): 1400-7. • Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C . The endometrial receptivity array (ERA) for diagnosis and personalised embryo transfer (pET) as a treatment for patients with repeated implantation failure (RIF). Fertil Steril. 2013; 100(3): 818-24. • Galan A, Diaz-Gimeno P, Poo ME, Valbuena D, Sanchez E, Ruiz V, Dopazo J, Montaner D, Conesa A, Simón C . Defining the genomic signature of totipotency and pluripotency during early human development. PLoS One. 2013; 8(4): e62135. • Simón C , Barnhart K. Preface. Biomarkers in reproductive medicine. Fertil Steril. 2013; 99(4): 953. • Dominguez F, Castello D, Remohí J, Simón C , Cobo A. Effect of vitrification on human oocytes: a metabolic profiling study. Fertil Steril. 2013; 99(2): 565-572.e3. • Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alamá P, Garrido N, Pellicer A, Simón C . The accuracy and reproducibility of the endometrial receptivity array is superior
27 to histology as a diagnostic method for endometrial receptivity. Fertil Steril. 2013; 99(2): 508-17. • Mir P, Rodrigo L, Mercader A, Buendía P, Mateu E, Milán-Sánchez M, Peinado V, Pellicer A, Remohí J, Simón C , Rubio C. False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3. J Assist Reprod Genet. 2013; 30(1): 143-9. • Cervelló I, Mas A, Gil-Sanchis C, Simón C . Somatic stem cells in the human endometrium. Semin Reprod Med. 2013; 31(1): 69-76. • Medrano JV, Pera RA, Simón C . Germ cell differentiation from pluripotent cells. Semin Reprod Med. 2013; 31(1): 14-23. • Aguilar-Gallardo C, Simón C . Cells, stem cells, and cancer stem cells. Semin Reprod Med. 2013; 31(1): 5-13. • Simón C . Stem cells helping reproductive medicine. Semin Reprod Med. 2013; 31(1): 3-4. ••• Ruiz-Alonso M, Vilella F, Blesa D, Simón C . Genomics and secretomics of endometrial receptivity. Clinical translation (Conference Paper). Giornale Italiano di Obstetricia e Ginecologia. 2013; 35(1) 100-9. 2012 • Ruiz-Alonso M, Blesa D, Simón C . The genomics of the human endometrium. Biochim Biophys Acta. 2012; 1822(12): 1931-42. • Sánchez-Ribas I, Riqueros M, Vime P, Puchades-Carrasco L, Jönsson T, Pineda-Lucena A, Ballesteros A, Domínguez F, Simón C . Differential metabolic profiling of non-pure trisomy 21 human preimplantation embryos. Fertil Steril. 2012; 98(5): 1157-64. • Garrido-Gómez T, Dominguez F, Quiñonero A, Estella C, Vilella F, Pellicer A, Simón C . Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F- actin regulation. FASEB J. 2012; 26(9): 3715-27. • Riboldi M, Rubio C, Pellicer A, Gil-Salom M, Simón C . In vitro production of haploid cells after coculture of CD49f+ with Sertoli cells from testicular sperm extraction in nonobstructive azoospermic patients. Fertil Steril. 2012; 98(3): 580-590.e4. • Mas A, Cervelló I, Gil-Sanchis C, Faus A, Ferro J, Pellicer A, Simón C . Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells. Fertil Steril. 2012; 98(3): 741-751.e6. • Paule S, Aljofan M, Simón C , Rombauts LJ, Nie G. Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6. Hum Reprod. 2012; 27(9): 2766-74. • Aguilar-Gallardo C, Rutledge EC, Martínez-Arroyo AM, Hidalgo JJ, Domingo S, Simón C . Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches. Stem Cell Rev. 2012; 8(3): 994-1010. • Simón C . Somatic stem cells and tissue engineering shed light on unsolved clinical issues in reproductive medicine: in stem cells we trust. Fertil Steril. 2012; 98(1): 1-2. • Al-Asmar N, Peinado V, Vera M, Remohí J, Pellicer A, Simón C , Hassold T, Rubio C. Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage. Fertil Steril. 2012; 98(1): 145-50. • Evans GE, Martínez-Conejero JA, Phillipson GT, Simón C , McNoe LA, Sykes PH, Horcajadas JA, Lam EY, Print CG, Sin IL, Evans JJ. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertil Steril. 2012; 97(6): 1365-73.e1-2. • Ferrero H, Delgado-Rosas F, Garcia-Pascual CM, Monterde M, Zimmermann RC, Simón C , Pellicer A, Gómez R. Efficiency and purity provided by the existing methods for the isolation of luteinized granulosa cells: a comparative study. Hum Reprod. 2012; 27(6): 1781-9. • Niakan KK, Han J, Pedersen RA, Simón C , Pera RA. Human pre-implantation embryo development. Development. 2012; 139(5): 829-41. • Medrano JV, Ramathal C, Nguyen HN, Simón C , Reijo Pera RA. Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro. Stem Cells. 2012; 30(3): 441-51. • García-Velasco JA, Kupesic S, Pellicer A, Bourgain C, Simón C , Mrazek M, Devroey P, Arce JC. Follicular and endocrine profiles associated with different GnRH-antagonist regimens: a randomized controlled trial. Reprod Biomed Online. 2012; 24(2): 153-62. • Valbuena D, Póo ME, Aguilar-Gallardo C, Martinez S, Cobo AC, Pellicer A, Simón C . Comparison
28 of Cryotip vs. Cryotop for mouse and human blastomere vitrification. Fertil Steril. 2012; 97(1): 209-17. • Galán A, Simón C . Human embryonic stem cells derived in xeno-free conditions. Methods Mol Biol. 2012; 873: 13-32. • Estella C, Herrer I, Moreno-Moya JM, Quiñonero A, Martínez S, Pellicer A, Simón C . miRNA signature and Dicer requirement during human endometrial stromal decidualization in vitro. PLoS One. 2012; 7(7): e41080. • Estella C, Herrer I, Atkinson SP, Quiñonero A, Martínez S, Pellicer A, Simón C . Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion. PLoS One. 2012; 7(1): e30508. • Cervelló I, Gil-Sanchis C, Mas A, Faus A, Sanz J, Moscardó F, Higueras G, Sanz MA, Pellicer A, Simón C . Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient. PLoS One. 2012; 7(1): e30260. • Carcel-Trullols J, Aguilar-Gallardo C, Garcia-Alcalde F, Pardo-Cea MA, Dopazo J, Conesa A, Simón C . Transdifferentiation of MALME-3M and MCF-7 cells toward adipocyte-like cells is dependent on clathrin-mediated endocytosis. Springerplus. 2012; 1: 44. 2011 • Heng S, Cervero A, Simón C , Stephens AN, Li Y, Zhang J, Paule S, Rainczuk A, Singh H, Quinonero A, Tapia A, Velasquez L, Salamonsen L, Rombauts LJ, Nie G. Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions. Endocrinology. 2011; 152(12): 5041-52. • Evian Annual Reproduction (EVAR) Workshop Group 2010, Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C , Devroey P, Ezcurra D, Howles CM. Contemporary genetic technologies and female reproduction. Hum Reprod Update. 2011; 17(6): 829-47. Erratum in: Hum Reprod Update. 2012; 18(2): 231. • Delgado-Rosas F, Gómez R, Ferrero H, Gaytan F, Garcia-Velasco J, Simón C , Pellicer A. The effects of ergot and non-ergot-derived dopamine agonists in an experimental mouse model of endometriosis. Reproduction. 2011; 142(5): 745-55. • Ruiz-Vela A, Aguilar-Gallardo C, Martínez-Arroyo AM, Soriano-Navarro M, Ruiz V, Simón C . Specific unsaturated fatty acids enforce the transdifferentiation of human cancer cells toward adipocyte-like cells. Stem Cell Rev. 2011; 7(4): 898-909. • Martínez-Conejero JA, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simón C , Horcajadas JA, Pellicer A. Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril. 2011; 96(4): 943-50. • Díaz-García C, Estella C, Perales-Puchalt A, Simón C . Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming. Fertil Steril. 2011; 96(3): 536-45. • Berlanga O, Bradshaw HB, Vilella-Mitjana F, Garrido-Gómez T, Simón C . How endometrial secretomics can help in predicting implantation. Placenta. 2011; 32 Suppl 3: S271-5. • Gómez R, Ferrero H, Delgado-Rosas F, Gaytan M, Morales C, Zimmermann RC, Simón C , Gaytan F, Pellicer A. Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment. J Clin Endocrinol Metab. 2011; 96(8): 2484-92. • Garrido N, Bellver J, Remohí J, Simón C , Pellicer A. Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success. Fertil Steril. 2011; 96(1): 40-6. • Labarta E, Martínez-Conejero JA, Alamá P, Horcajadas JA, Pellicer A, Simón C , Bosch E. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011; 26(7): 1813-25. • Cervelló I, Mirantes C, Santamaria X, Dolcet X, Matias-Guiu X, Simón C . Stem cells in human endometrium and endometrial carcinoma. Int J Gynecol Pathol. 2011; 30(4): 317-27. • Pellicer B, Herraiz S, Táboas E, Felipo V, Simón C , Pellicer A. Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging. Ultrasound Obstet Gynecol. 2011; 37(6): 643-8. • Pellicer B, Herraiz S, Cauli O, Rodrigo R, Asensi M, Cortijo J, Serra V, Morcillo E, Felipo V, Simón C , Pellicer A. Haemodynamic effects of long-term administration of sildenafil in
29 normotensive pregnant and non-pregnant rats. BJOG. 2011; 118(5): 615-23. • Rodrigo L, Rubio C, Peinado V, Villamón R, Al-Asmar N, Remohí J, Pellicer A, Simón C , Gil- Salom M. Testicular sperm from patients with obstructive and nonobstructive azoospermia: aneuploidy risk and reproductive prognosis using testicular sperm from fertile donors as control samples. Fertil Steril. 2011; 95(3): 1005-12. • Bosch E, Labarta E, Crespo J, Simón C , Remohí J, Pellicer A. Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis. Fertil Steril. 2011; 95(3): 1031-6. • Gómez R, Abad A, Delgado F, Tamarit S, Simón C , Pellicer A. Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia. Fertil Steril. 2011; 95(3): 882-8.e1. • Garrido-Gomez T, Dominguez F, Lopez JA, Camafeita E, Quiñonero A, Martinez-Conejero JA, Pellicer A, Conesa A, Simón C . Modeling human endometrial decidualization from the interaction between proteome and secretome. J Clin Endocrinol Metab. 2011; 96(3): 706-16. • Panula S, Medrano JV, Kee K, Bergström R, Nguyen HN, Byers B, Wilson KD, Wu JC, Simón C , Hovatta O, Reijo Pera RA. Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells. Hum Mol Genet. 2011; 20(4): 752-62. • Garcia-Velasco JA, Bennink HJ, Epifanio R, Escudero E, Pellicer A, Simón C . High-dose recombinant LH add-back strategy using high-dose GnRH antagonist is an innovative protocol compared with standard GnRH antagonist. Reprod Biomed Online. 2011; 22 Suppl 1: S52-9. • Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011; 95(1): 50-60, 60.e1-15. • Pellicer B, Herraiz S, Leal A, Simón C , Pellicer A. Prenatal brain damage in preeclamptic animal model induced by gestational nitric oxide synthase inhibition. J Pregnancy. 2011; 2011: 809569. • Cervelló I, Mas A, Gil-Sanchis C, Peris L, Faus A, Saunders PT, Critchley HO, Simón C . Reconstruction of endometrium from human endometrial side population cell lines. PLoS One. 2011; 6(6): e21221. 2010 • Novella-Maestre E, Carda C, Ruiz-Sauri A, Garcia-Velasco JA, Simón C , Pellicer A. Identification and quantification of dopamine receptor 2 in human eutopic and ectopic endometrium: a novel molecular target for endometriosis therapy. Biol Reprod. 2010; 83(5): 866-73. • Masip M, Veiga A, Izpisúa Belmonte JC, Simón C . Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation. Mol Hum Reprod. 2010; 16(11): 856-68. • Medrano JV, Marqués-Marí AI, Aguilar CE, Riboldi M, Garrido N, Martínez-Romero A, O'Connor E, Gil-Salom M, Simón C . Comparative analysis of the germ cell markers c-KIT, SSEA-1 and VASA in testicular biopsies from secretory and obstructive azoospermias. Mol Hum Reprod. 2010; 16(11): 811-7. • Milán M, Cobo AC, Rodrigo L, Mateu E, Mercader A, Buendía P, Peinado V, Delgado A, Mir P, Simón C , Remohí J, Pellicer A, Rubio C. Redefining advanced maternal age as an indication for preimplantation genetic screening. Reprod Biomed Online. 2010; 21(5): 649-57. • Gómez R, Soares SR, Busso C, Garcia-Velasco JA, Simón C , Pellicer A. Physiology and pathology of ovarian hyperstimulation syndrome. Semin Reprod Med. 2010; 28(6): 448-57. • Galán A, Montaner D, Póo ME, Valbuena D, Ruiz V, Aguilar C, Dopazo J, Simón C . Functional genomics of 5- to 8-cell stage human embryos by blastomere single-cell cDNA analysis. PLoS One. 2010; 5(10): e13615. • Domínguez F, Simón C , Quiñonero A, Ramírez MÁ, González-Muñoz E, Burghardt H, Cervero A, Martínez S, Pellicer A, Palacín M, Sánchez-Madrid F, Yáñez-Mó M. Human endometrial CD98 is essential for blastocyst adhesion. PLoS One. 2010; 5(10): e13380. • Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C , Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril. 2010; 94(4): 1380-6. • Bosch E, Labarta E, Crespo J, Simón C , Remohí J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010; 25(8): 2092-100. • Cervelló I, Gil-Sanchis C, Mas A, Delgado-Rosas F, Martínez-Conejero JA, Galán A, Martínez-
30 Romero A, Martínez S, Navarro I, Ferro J, Horcajadas JA, Esteban FJ, O'Connor JE, Pellicer A, Simón C . Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells. PLoS One. 2010; 5(6): e10964. • Busso C, Fernández-Sánchez M, García-Velasco JA, Landeras J, Ballesteros A, Muñoz E, González S, Simón C , Arce JC, Pellicer A. The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double- blind, placebo-controlled trial. Hum Reprod. 2010; 25(4): 995-1004. • Aguilar-Gallardo C, Poo M, Gomez E, Galan A, Sanchez E, Marques-Mari A, Ruiz V, Medrano J, Riboldi M, Valbuena D, Simón C . Derivation, characterization, differentiation, and registration of seven human embryonic stem cell lines (VAL-3, -4, -5, -6M, -7, -8, and -9) on human feeder. In Vitro Cell Dev Biol Anim. 2010; 46(3-4): 317-26. • Altmäe S, Martínez-Conejero JA, Salumets A, Simón C , Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod. 2010; 16(3): 178-87. • Dominguez F, Gadea B, Mercader A, Esteban FJ, Pellicer A, Simón C . Embryologic outcome and secretome profile of implanted blastocysts obtained after coculture in human endometrial epithelial cells versus the sequential system. Fertil Steril. 2010; 93(3): 774-782.e1. • Mosher JT, Pemberton TJ, Harter K, Wang C, Buzbas EO, Dvorak P, Simón C , Morrison SJ, Rosenberg NA. Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med. 2010; 362(2): 183-5. • Sánchez-Serrano M, Crespo J, Mirabet V, Cobo AC, Escribá MJ, Simón C , Pellicer A. Twins born after transplantation of ovarian cortical tissue and oocyte vitrification. Fertil Steril. 2010; 93(1): 268.e11-3. • Garrido-Gómez T, Dominguez F, Simón C . Proteomics of embryonic implantation. Handb Exp Pharmacol. 2010; (198): 67-78. • Galán A, Simón C . Monitoring stemness in long-term hESC cultures by real-time PCR. Methods Mol Biol. 2010; 584: 135-50. • Simón C . A mother’s gift, minus mitochondria. Nat Med. 2010; 16(6): 645. 2009 • Ruiz-Vela A, Aguilar-Gallardo C, Simón C . Building a framework for embryonic microenvironments and cancer stem cells. Stem Cell Rev. 2009; 5(4): 319-27. • International Stem Cell Banking Initiative. Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. Stem Cell Rev. 2009; 5(4): 301-14. • Domínguez F, Garrido-Gómez T, López JA, Camafeita E, Quiñonero A, Pellicer A, Simón C . Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1 and annexin A2 as differentially regulated. Hum Reprod. 2009; 24(10): 2607-17. • Unger C, Gao S, Cohen M, Jaconi M, Bergstrom R, Holm F, Galan A, Sanchez E, Irion O, Dubuisson JB, Giry-Laterriere M, Salmon P, Simón C , Hovatta O, Feki A. Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells. Hum Reprod. 2009; 24(10): 2567-81. • Sermon KD, Simón C , Braude P, Viville S, Borstlap J, Veiga A. Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg. Hum Reprod. 2009; 24(7): 1556-60. • Busso CE, Garcia-Velasco J, Gomez R, Alvarez C, Simón C , Pellicer A. Symposium: Update on prediction and management of OHSS. Prevention of OHSS--dopamine agonists. Reprod Biomed Online. 2009; 19(1): 43-51. • Riboldi M, Simón C . Extraembryonic tissues as a source of stem cells. Gynecol Endocrinol. 2009; 25(6): 351-5. • Novella-Maestre E, Carda C, Noguera I, Ruiz-Saurí A, García-Velasco JA, Simón C , Pellicer A. Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis. Hum Reprod. 2009; 24(5): 1025-35. • Marques-Mari AI, Lacham-Kaplan O, Medrano JV, Pellicer A, Simón C . Differentiation of germ cells and gametes from stem cells. Hum Reprod Update. 2009; 15(3): 379-90. • Rubio C, Buendía P, Rodrigo L, Mercader A, Mateu E, Peinado V, Delgado A, Milán M, Mir P, Simón C , Remohí J, Pellicer A. Prognostic factors for preimplantation genetic screening in
31 repeated pregnancy loss. Reprod Biomed Online. 2009; 18(5): 687-93. • Ensenat-Waser R, Pellicer A, Simón C . Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine? Fertil Steril. 2009; 91(4): 971-4. • Garrido N, Martínez-Conejero JA, Jauregui J, Horcajadas JA, Simón C , Remohí J, Meseguer M. Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome. Fertil Steril. 2009; 91(4 Suppl): 1307- 10. • Blockeel C, Mock P, Verheyen G, Bouche N, Le Goff P, Heyman Y, Wrenzycki C, Höffmann K, Niemann H, Haentjens P, de Los Santos MJ, Fernandez-Sanchez M, Velasco M, Aebischer P, Devroey P, Simón C . An in vivo culture system for human embryos using an encapsulation technology: a pilot study. Hum Reprod. 2009; 24(4): 790-6. • Cervelló I, Simón C . Somatic stem cells in the endometrium. Reprod Sci. 2009; 16(2): 200-5. • Dominguez F, Pellicer A, Simón C . The human embryo proteome. Reprod Sci. 2009; 16(2): 188- 90. • Cervelló I, Gil-Sanchís C, Más A, Simón C . Current Understanding of endometrial stem cells. Expert. Rev. Obstet. Gynecol. 2009; 4(3): 273-82. 2008 • Horcajadas JA, Mínguez P, Dopazo J, Esteban FJ, Domínguez F, Giudice LC, Pellicer A, Simón C. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab. 2008; 93(11): 4500-10. • Bosch E, Vidal C, Labarta E, Simón C , Remohi J, Pellicer A. Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists—a randomized study. Hum Reprod. 2008; 23(10): 2346-51. • Simón C . New perspectives in medically assisted procreation. Gynecol Endocrinol. 2008; 24(9): 485. • Domínguez F, Gadea B, Esteban FJ, Horcajadas JA, Pellicer A, Simón C . Comparative protein- profile analysis of implanted versus non-implanted human blastocysts. Hum Reprod. 2008; 23(9): 1993-2000. • Horcajadas JA, Goyri E, Higón MA, Martínez-Conejero JA, Gambadauro P, García G, Meseguer M, Simón C , Pellicer A. Endometrial receptivity and implantation are not affected by the presence of uterine intramural leiomyomas: a clinical and functional genomics analysis. J Clin Endocrinol Metab. 2008; 93(9): 3490-8. • Martínez-Conejero JA, Garrido N, Remohí J, Pellicer A, Simón C , Meseguer M. MUC1 in human testis and ejaculated spermatozoa and its relationship to male fertility status. Fertil Steril. 2008; 90(2): 450-2. • Aleckovic M, Simón C . Is teratoma formation in stem cell research a characterization tool or a window to developmental biology? Reprod Biomed Online. 2008; 17(2): 270-80. • Soares SR, Gómez R, Simón C , García-Velasco JA, Pellicer A. Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome. Hum Reprod Update. 2008; 14(4): 321-33. • Dominguez F, Martínez S, Quiñonero A, Loro F, Horcajadas JA, Pellicer A, Simón C . CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines. Mol Hum Reprod. 2008; 14(7): 423-30. • Valbuena D, Sánchez-Luengo S, Galán A, Sánchez E, Gómez E, Poo ME, Ruiz V, Genbacev O, Krtolica A, Pellicer A, Moreno R, Simón C . Efficient method for slow cryopreservation of human embryonic stem cells in xeno-free conditions. Reprod Biomed Online. 2008; 17(1): 127-35. • Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, Simón C . Clinical factors affecting endometrial receptiveness in oocyte donation cycles. Fertil Steril. 2008; 89(3): 491-501. • Horne AW, Phillips JA 3rd, Kane N, Lourenco PC, McDonald SE, Williams AR, Simón C , Dey SK, Critchley HO. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS One. 2008; 3(12): e3969. • Aghajanova L, Simón C , Horcajadas JA. Functional genomic of human implantation: are favorite molecules of endometrial receptivity still in favor? Expert Review of Obstetrics and Gynecology. 2008; 3(4): 487-501. • Simón C . European funding for reproduction research-A multinational perspective. Nat Med. 2008; 14(11): 1222. • Hyun I, Lindvall O, Ährlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Lucra M,
32 Ira J. Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, OkKim H, Lee HP, Levy-Lahad E, Li, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Simón C , Srivastava A, Sugarman J, Taylor PL, Veiga A, Way AL, Zoloth L, Daley GQ. New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell. 2008; 3(6): 607-60. 2007 • Alvarez C, Alonso-Muriel I, García G, Crespo J, Bellver J, Simón C , Pellicer A. Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study. Hum Reprod. 2007; 22(12): 3210-4. • Horcajadas JA, Díaz-Gimeno P, Pellicer A, Simón C . Uterine receptivity and the ramifications of ovarian stimulation on endometrial function. Semin Reprod Med. 2007; 25(6): 454-60. • Cervero A, Domínguez F, Horcajadas JA, Quiñonero A, Pellicer A, Simón C . Embryonic adhesion is not affected by endometrial leptin receptor gene silencing. Fertil Steril. 2007; 88(4 Suppl): 1086-92. • Garcia-Velasco JA, Coelingh Bennink HJ, Epifanio R, Escudero E, Pellicer A, Simón C . High- dose recombinant LH add-back strategy using high-dose GnRH antagonist is an innovative protocol compared with standard GnRH antagonist. Reprod Biomed Online. 2007; 15(3): 280-7. • Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simón C , Mostov K, Fisher SJ. Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells. 2007; 25(9): 2215-23. • Alvarez C, Martí-Bonmatí L, Novella-Maestre E, Sanz R, Gómez R, Fernández-Sánchez M, Simón C , Pellicer A. Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction. J Clin Endocrinol Metab. 2007; 92(8): 2931-7. • Rubio C, Rodrigo L, Mercader A, Mateu E, Buendía P, Pehlivan T, Viloria T, De los Santos MJ, Simón C , Remohí J, Pellicer A. Impact of chromosomal abnormalities on preimplantation embryo development. Prenat Diagn. 2007; 27(8): 748-56. • Martínez-Conejero JA, Simón C , Pellicer A, Horcajadas JA. Is ovarian stimulation detrimental to the endometrium? Reprod Biomed Online. 2007; 15(1): 45-50. • Sánchez M, Alamá P, Gadea B, Soares SR, Simón C , Pellicer A. Fresh human orthotopic ovarian cortex transplantation: long-term results. Hum Reprod. 2007; 22(3): 786-91. • Martínez S, Garrido N, Coperias JL, Pardo F, Desco J, García-Velasco JA, Simón C , Pellicer A. Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. Hum Reprod. 2007; 22(3): 836-42. • Soares SR, Simón C , Remohí J, Pellicer A. Cigarette smoking affects uterine receptiveness. Hum Reprod. 2007; 22(2): 543-7. • Cervelló I, Martínez-Conejero JA, Horcajadas JA, Pellicer A, Simón C . Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers. Hum Reprod. 2007; 22(1): 45-51. • Horcajadas JA, Pellicer A, Simón C . Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update. 2007; 13(1): 77-86. • Garrido N, Melo MAB, Simón C , Remohí J, Pellicer A, Meseguer M. Ovarian stimulation length, number of follicles higher than 17 mm and estradiol on the day of human chorionic gonadotropin administration are risk factors for multiple pregnancy in intrauterine insemination. Reprod. Med. Biol. 2007; 6: 19-26. • Diedrich K, Fauser BCJM, Devroy P, Griesinger G on behalf of the Evian Annual Reproduction (EVAR) Workshop Group. The role of endometrium and embryo in human implantation. Hum Reprod Update. 2007; 13(4): 365-77. 2006 • Escribá MJ, Martín J, Rubio C, Valbuena D, Remohí J, Pellicer A, Simón C . Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos. Fertil Steril. 2006; 86(6): 1601-7. • Valbuena D, Galán A, Sánchez E, Poo ME, Gómez E, Sánchez-Luengo S, Melguizo D, García A, Ruiz V, Moreno R, Pellicer A, Simón C . Derivation and characterization of three new Spanish human embryonic stem cell lines (VAL -3 -4 -5) on human feeder and in serum-free conditions. Reprod Biomed Online. 2006; 13(6): 875-86.
33 • Gomez R, Gonzalez-Izquierdo M, Zimmermann RC, Novella-Maestre E, Alonso-Muriel I, Sanchez-Criado J, Remohi J, Simón C , Pellicer A. Low-dose dopamine agonist administration blocks vascular endothelial growth factor (VEGF)-mediated vascular hyperpermeability without altering VEGF receptor 2-dependent luteal angiogenesis in a rat ovarian hyperstimulation model. Endocrinology. 2006; 147(11): 5400-11. • Meseguer M, de los Santos MJ, Simón C , Pellicer A, Remohí J, Garrido N. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertil Steril. 2006; 86(5): 1376-85. • Busso CE, Melo MA, Fernandez M, Pellicer A, Simón C . Implantation in IVF. Int Surg. 2006; 91(5 Suppl): S63-76. • Horcajadas JA, Sharkey AM, Catalano RD, Sherwin JR, Domínguez F, Burgos LA, Castro A, Peraza MR, Pellicer A, Simón C . Effect of an intrauterine device on the gene expression profile of the endometrium. J Clin Endocrinol Metab. 2006; 91(8): 3199-207. • Cervero A, Domínguez F, Horcajadas JA, Quiñonero A, Pellicer A, Simón C . The role of the leptin in reproduction. Curr Opin Obstet Gynecol. 2006; 18(3): 297-303. • Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C , Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril. 2006; 85(6): 1563-81. • Pau E, Alonso-Muriel I, Gómez R, Novella E, Ruiz A, García-Velasco JA, Simón C , Pellicer A. Plasma levels of soluble vascular endothelial growth factor receptor-1 may determine the onset of early and late ovarian hyperstimulation syndrome. Hum Reprod. 2006; 21(6): 1453-60 • Bellver J, Busso C, Pellicer A, Remohí J, Simón C . Obesity and assisted reproductive technology outcomes. Reprod Biomed Online. 2006; 12(5): 562-8. • Bischof P, Aplin JD, Bentin-Ley U, Brannstrom M, Casslen B, Castrillo JL, Classen-Linke I, Critchley HO, Devoto L, D'Hooghe T, Horcajadas JA, Groothuis P, Ivell R, Pongrantz I, Macklon NS, Sharkey A, Vicovac L, White JO, Winterhager E, von Wolff M, Simón C , Stavreus-Evers A. Implantation of the human embryo: research lines and models. From the implantation research network 'Fruitful'. Gynecol Obstet Invest. 2006; 62(4): 206-16. • Mercader A, Valbuena D, Simón C . Human embryo culture. Methods Enzymol. 2006; 420: 3-18. • Rodríguez CI, Simón C . Human embryonic stem cell derivation: from the IVF perspective to therapeutic applications. Regen Med. 2006; 1(1): 103-9. • Rodríguez CI, Galán A, Valbuena D, Simón C . Derivation of clinical-grade human embryonic stem cells. Reprod Biomed Online. 2006; 12(1): 112-8. • Simón C , Domínguez F. Embryo-endometrial interaction. Chang Gung Med J.2006; 29(1): 9-14. • Tarlatzis A, Fauser B, Kolibianakis EM, Diedrich K, Devroey P, On behalf of the Brussels GnRH antagonist consensus workshop group. GnRH antagonist in ovarian stimulation for IVF. Hum Reprod Update. 2006; 12(4): 333-340. 2005 • Simón C , Oberyé J, Bellver J, Vidal C, Bosch E, Horcajadas JA, Murphy C, Adams S, Riesewijk A, Mannaerts B, Pellicer A. Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles. Hum Reprod. 2005; 20(12): 3318-27. • Bosch E, Escudero E, Crespo J, Simón C , Remohí J, Pellicer A. Serum luteinizing hormone in patients undergoing ovarian stimulation with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone and its relationship with cycle outcome. Fertil Steril. 2005; 84(5): 1529-32. • Matorras R, Matorras F, Mendoza R, Rodríguez M, Remohí J, Rodríguez-Escudero FJ, Simón C . The implantation of every embryo facilitates the chances of the remaining embryos to implant in an IVF programme: a mathematical model to predict pregnancy and multiple pregnancy rates. Hum Reprod. 2005; 20(10): 2923-31. • Rubio C, Rodrigo L, Pérez-Cano I, Mercader A, Mateu E, Buendía P, Remohí J, Simón C , Pellicer A. FISH screening of aneuploidies in preimplantation embryos to improve IVF outcome. Reprod Biomed Online. 2005; 11(4): 497-506. • Dominguez F, Yáñez-Mó M, Sanchez-Madrid F, Simón C . Embryonic implantation and leukocyte transendothelial migration: different processes with similar players? FASEB J. 2005; 19(9): 1056-60. • Soares SR, Troncoso C, Bosch E, Serra V, Simón C , Remohí J, Pellicer A. Age and uterine
34 receptiveness: predicting the outcome of oocyte donation cycles. J Clin Endocrinol Metab. 2005; 90(7): 4399-404. • Rubio C, Pehlivan T, Rodrigo L, Simón C , Remohí J, Pellicer A. Embryo aneuploidy screening for unexplained recurrent miscarriage: a minireview. Am J Reprod Immunol. 2005; 53(4): 159-65. • Garrido N, Meseguer M, Remohí J, Simón C , Pellicer A. Semen characteristics in human immunodeficiency virus (HIV)- and hepatitis C (HCV)-seropositive males: predictors of the success of viral removal after sperm washing. Hum Reprod. 2005; 20(4): 1028-34. • Escudero EL, Boerrigter PJ, Bennink HJ, Epifanio R, Horcajadas JA, Olivennes F, Pellicer A, Simón C . Mifepristone is an effective oral alternative for the prevention of premature luteinizing hormone surges and/or premature luteinization in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2005; 90(4): 2081-8. • Horcajadas JA, Riesewijk A, Polman J, van Os R, Pellicer A, Mosselman S, Simón C . Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod. 2005; 11(3): 195-205. • Cervero A, Horcajadas JA, Domínguez F, Pellicer A, Simón C . Leptin system in embryo development and implantation: a protein in search of a function. Reprod Biomed Online. 2005; 10(2): 217-23. • Simón C , Escobedo C, Valbuena D, Genbacev O, Galan A, Krtolica A, Asensi A, Sánchez E, Esplugues J, Fisher S, Pellicer A. First derivation in Spain of human embryonic stem cell lines: use of long-term cryopreserved embryos and animal-free conditions. Fertil Steril. 2005; 83(1): 246-9. 2004 • Horcajadas JA, Riesewijk A, Domínguez F, Cervero A, Pellicer A, Simón C . Determinants of endometrial receptivity. Ann N Y Acad Sci. 2004; 1034:166-75. • Meseguer M, Garrido N, Martínez-Conejero JA, Simón C , Pellicer A, Remohí J. Relationship between standard semen parameters, calcium, cholesterol contents, and mitochondrial activity in ejaculated spermatozoa from fertile and infertile males. J Assist Reprod Genet. 2004; 21(12): 445-51. • Garrido N, Meseguer M, Bellver J, Remohí J, Simón C , Pellicer A. Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples. Hum Reprod. 2004; 19(11): 2581-6. • Lima-Couy I, Cervero A, Bonilla-Musoles F, Pellicer A, Simón C . Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis. Mol Hum Reprod. 2004; 10(11): 777-82. • Garrido N, Meseguer M, Alvarez J, Simón C , Pellicer A, Remohí J. Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men. Fertil Steril. 2004; 82 Suppl 3: 1059-66. • Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa. J Androl. 2004; 25(5): 773-80. • Horcajadas JA, Riesewijk A, Martín J, Cervero A, Mosselman S, Pellicer A, Simón C . Global gene expression profiling of human endometrial receptivity. J Reprod Immunol. 2004; 63(1): 41-9. • García-Velasco JA, Zúñiga A, Pacheco A, Gómez R, Simón C , Remohí J, Pellicer A. Coasting acts through downregulation of VEGF gene expression and protein secretion. Hum Reprod. 2004; 19(7): 1530-8. • Cervero A, Horcajadas JA, MartIn J, Pellicer A, Simón C . The leptin system during human endometrial receptivity and preimplantation development. J Clin Endocrinol Metab. 2004; 89(5): 2442-51. • Zuzuarregui JL, Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. Parameters affecting the results in a program of artificial insemination with donor sperm. A 12-year retrospective review of more than 1800 cycles. J Assist Reprod Genet. 2004; 21(4): 109-18. • Gómez R, Lima I, Simón C , Pellicer A. Administration of low-dose LH induces ovulation and prevents vascular hyperpermeability and vascular endothelial growth factor expression in superovulated rats. Reproduction. 2004; 127(4): 483-9. • Garrido N, Meseguer M, Simón C , Pellicer A, Remohi J. Assisted reproduction in HIV and HCV infected men of serodiscordant couples. Arch Androl. 2004; 50(2): 105-11. • Garrido N, Meseguer M, Simón C , Pellicer A, Remohi J. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl. 2004; 6(1): 59-65.
35 • Meseguer M, Garrido N, Martínez-Conejero JA, Simón C , Pellicer A, Remohí J. Role of cholesterol, calcium, and mitochondrial activity in the susceptibility for cryodamage after a cycle of freezing and thawing. Fertil Steril. 2004; 81(3): 588-94. • Escudero E, Bosch E, Crespo J, Simón C , Remohí J, Pellicer A. Comparison of two different starting multiple dose gonadotropin-releasing hormone antagonist protocols in a selected group of in vitro fertilization-embryo transfer patients. Fertil Steril. 2004; 81(3): 562-6. • Pehlivan T, Rubio C, Ruiz A, Navarro J, Remohí J, Pellicer A, Simón C . Embryonic chromosomal abnormalities obtained after rescue intracytoplasmic sperm injection of 1-day-old unfertilized oocytes. J Assist Reprod Genet. 2004; 21(2): 55-7. • Luna JJ, Riesewijk A, Horcajadas JA, Van Os Rd Rd, Domínguez F, Mosselman S, Pellicer A, Simón C . Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. Mol Hum Reprod. 2004; 10(2): 85-90. • Simón C , García-Velasco J. Medical treatment of endometriosis. Gynecol Obstet Invest. 2004; 57(1): 51-2. • Simón C , Dominguez F. Embryonic-endometrial interactions at implantation in humans. Gynecol Obstet Invest. 2004; 57(1): 28-30. • Rodrigo L, Rubio C, Mateu E, Simón C , Remohí J, Pellicer A, Gil-Salom M. Analysis of chromosomal abnormalities in testicular and epididymal spermatozoa from azoospermic ICSI patients by fluorescence in-situ hybridization. Hum Reprod. 2004; 19(1): 118-23. • Simón C , Pellicer A. Guest editorial. J Reprod Immunol. 2004; 63(1): 39. 2003 • Bosch E, Valencia I, Escudero E, Crespo J, Simón C , Remohí J, Pellicer A. Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril. 2003; 80(6): 1444-9. • Mercader A, Garcia-Velasco JA, Escudero E, Remohí J, Pellicer A, Simón C . Clinical experience and perinatal outcome of blastocyst transfer after coculture of human embryos with human endometrial epithelial cells: a 5-year follow-up study. Fertil Steril. 2003; 80(5): 1162-8. • Gámiz P, Rubio C, de los Santos MJ, Mercader A, Simón C , Remohí J, Pellicer A. The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos. Hum Reprod. 2003; 18(11): 2413-9. • Bellver J, Muñoz EA, Ballesteros A, Soares SR, Bosch E, Simón C , Pellicer A, Remohí J. Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study. Hum Reprod. 2003; 18(11): 2283-8. • Dominguez F, Pellicer A, Simón C . The chemokine connection: hormonal and embryonic regulation at the human maternal-embryonic interface--a review. Placenta. 2003; 24 Suppl B: S48-55. • Krüssel JS, Bielfeld P, Polan ML, Simón C . Regulation of embryonic implantation. Eur J Obstet Gynecol Reprod Biol. 2003; 10 Suppl 1: S2-9. • Reis Soares S, Rubio C, Rodrigo L, Simón C , Remohí J, Pellicer A. High frequency of chromosomal abnormalities in embryos obtained from oocyte donation cycles. Fertil Steril. 2003; 80(3): 656-7. • Pehlivan T, Rubio C, Rodrigo L, Remohí J, Pellicer A, Simón C . Preimplantation genetic diagnosis by fluorescence in situ hybridization: clinical possibilities and pitfalls. J Soc Gynecol Investig. 2003; 10(6): 315-22. • Garcia-Velasco JA, Isaza V, Caligara C, Pellicer A, Remohí J, Simón C . Factors that determine discordant outcome from shared oocytes. Fertil Steril. 2003; 80(1): 54-60. • Simón C , Domínguez F, Valbuena D, Pellicer A. The role of estrogen in uterine receptivity and blastocyst implantation. Trends Endocrinol Metab. 2003; 14(5): 197-9. • Gómez R, Simón C , Remohí J, Pellicer A. Administration of moderate and high doses of gonadotropins to female rats increases ovarian vascular endothelial growth factor (VEGF) and VEGF receptor-2 expression that is associated to vascular hyperpermeability. Biol Reprod. 2003; 68(6): 2164-71. • Meseguer M, Garrido N, Remohí J, Pellicer A, Simón C , Martínez-Jabaloyas JM, Gil-Salom M. Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy. Hum Reprod. 2003; 18(6): 1281-5. • Bellver J, Rossal LP, Bosch E, Zúñiga A, Corona JT, Meléndez F, Gómez E, Simón C , Remohí J,
36 Pellicer A. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril. 2003; 79(5): 1136-40. • Riesewijk A, Martín J, van Os R, Horcajadas JA, Polman J, Pellicer A, Mosselman S, Simón C . Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol Hum Reprod. 2003; 9(5):253-64. • Garrido N, Pellicer A, Remohí J, Simón C . Uterine and ovarian function in endometriosis. Semin Reprod Med. 2003; 21(2): 183-92. • Domínguez F, Avila S, Cervero A, Martín J, Pellicer A, Castrillo JL, Simón C . A combined approach for gene discovery identifies insulin-like growth factor-binding protein-related protein 1 as a new gene implicated in human endometrial receptivity. J Clin Endocrinol Metab. 2003; 88(4): 1849-57. • Dominguez F, Galan A, Martin JJ, Remohi J, Pellicer A, Simón C . Hormonal and embryonic regulation of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in the human endometrium and the human blastocyst. Mol Hum Reprod. 2003; 9(4): 189-98. • Domínguez F, Remohí J, Pellicer A, Simón C . Human endometrial receptivity: a genomic approach. Reprod Biomed Online. 2003; 6(3): 332-8. • Pehlivan T, Rubio C, Rodrigo L, Romero J, Remohi J, Simón C , Pellicer A. Impact of preimplantation genetic diagnosis on IVF outcome in implantation failure patients. Reprod Biomed Online. 2003; 6(2): 232-7. • Troncoso C, Bosch E, Rubio C, Remohí J, Simón C , Pellicer A. The origin of biochemical pregnancies: lessons learned from preimplantation genetic diagnosis. Fertil Steril. 2003; 79(2): 449-50. • Isaza V, Requena A, García-Velasco JA, Remohí J, Pellicer A, Simón C . Recombinant vs. urinary follicle-stimulating hormone in couples undergoing intrauterine insemination. A randomized study. J Reprod Med. 2003; 48(2): 112-8. • Hey NA, Meseguer M, Simón C , Smorodinsky NI, Wreschner DH, Ortíz ME, Aplin JD. Transmembrane and truncated (SEC) isoforms of MUC1 in the human endometrium and Fallopian tube. Reprod Biol Endocrinol. 2003; 1: 2. • Rubio C, Simón C , Vidal F, Rodrigo L, Pehlivan T, Remohí J, Pellicer A. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum Reprod. 2003; 18(1): 182-8. 2002 • Meseguer M, Garrido N, Gimeno C, Remohí J, Simón C , Pellicer A. Comparison of polymerase chain reaction-dependent methods for determining the presence of human immunodeficiency virus and hepatitis C virus in washed sperm. Fertil Steril. 2002; 78(6): 1199-202. • Garrido N, Meseguer M, Remohi J, Pellicer A, Simón C . Flow cytometry in human reproductive biology. Gynecol Endocrinol. 2002; 16(6): 505-21. • Garrido N, Zuzuarregui JL, Meseguer M, Simón C , Remohí J, Pellicer A. Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates. Hum Reprod. 2002; 17(12): 3142-8. • Gómez R, Simón C , Remohí J, Pellicer A. Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade. Endocrinology. 2002; 143(11): 4339-48. • Pellicer A, Simón C . Ethics of oocyte cryopreservation in Spain. Reprod Biomed Online. 2002; 5(3): 230. • Bellver J, Simón C , Pellicer A. Estrogen levels and thrombophilia—an intervening variable or a confounder? Fertil Steril. 2002; 78(4): 887-8 • García-Velasco JA, Isaza V, Martinez-Salazar J, Landazábal A, Requena A, Remohí J, Simón C . Transabdominal ultrasound-guided embryo transfer does not increase pregnancy rates in oocyte recipients. Fertil Steril. 2002; 78(3): 534-9. • Meseguer M, Garrido N, Remohí J, Simón C , Pellicer A. Gender selection: ethical, scientific, legal, and practical issues. J Assist Reprod Genet. 2002; 19(9): 443-6. • Pellicer A, Valbuena D, Simón C . An experimental bagatelle or a wrong mistake? Fertil Steril. 2002; 78(2): 434-5; • Isaza V, García-Velasco JA, Aragonés M, Remohí J, Simón C , Pellicer A. Oocyte and embryo quality after coasting: the experience from oocyte donation. Hum Reprod. 2002; 17(7): 1777-82..
37 • Escribá MJ, Valbuena D, Remohí J, Pellicer A, Simón C . New techniques on embryo manipulation. J Reprod Immunol. 2002; 55(1-2): 149-61. • Martín J, Domínguez F, Avila S, Castrillo JL, Remohí J, Pellicer A, Simón C . Human endometrial receptivity: gene regulation. J Reprod Immunol. 2002; 55(1-2): 131-9. • Albert C, Garrido N, Mercader A, Rao CV, Remohí J, Simón C , Pellicer A. The role of endothelial cells in the pathogenesis of ovarian hyperstimulation syndrome. Mol Hum Reprod. 2002; 8(5): 409-18. • Domínguez F, Remohí J, Pellicer A, Simón C . Paracrine interactions during human implantation. Rev Endocr Metab Disord. 2002; 3(2): 97-105. • Caballero-Campo P, Domínguez F, Coloma J, Meseguer M, Remohí J, Pellicer A, Simón C . Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation. Mol Hum Reprod. 2002; 8(4): 375-84. • Dominguez F, Pellicer A, Simón C . Paracrine dialogue in implantation. Mol Cell Endocrinol. 2002; 186(2): 175-81. • Garrido N, Navarro J, García-Velasco J, Remoh J, Pellice A, Simón C . The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002; 8(1): 95-103. • Garrido N, Krüssel JS, Remohí J, Simón C , Pellicer A. Expression and function of 3beta hydroxisteroid dehydrogenase (3beta HSD) type II and corticosteroid binding globulin (CBG) in granulosa cells from ovaries of women with and without endometriosis. J Assist Reprod Genet. 2002; 19(1): 24-30. • Pellicer A, Dominguez F, Remohi J, Simón C . Molecular basis of implantation. Reprod Biomed Online. 2002; 5 Suppl 1(3): 44-51. • Krüssel J-S, Polan M.L, Simón C . Cytokine and growth factor network in human endometrium. Immunology and allergy Clinics of North America. 2002; 22: 529-43. 2001 • Garcia-Velasco JA, Isaza V, Vidal C, Landazábal A, Remohí J, Simón C , Pellicer A. Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix). Hum Reprod. 2001; 16(12): 2533-9. • Valbuena D, Martin J, de Pablo JL, Remohí J, Pellicer A, Simón C . Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril. 2001; 76(5): 962-8. • Caligara C, Navarro J, Vargas G, Simón C , Pellicer A, Remohí J. The effect of repeated controlled ovarian stimulation in donors. Hum Reprod. 2001; 16(11): 2320-3. • Rubio C, Gil-Salom M, Simón C , Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod. 2001; 16(10): 2084-92. • Pellicer A, Navarro J, Bosch E, Garrido N, Garcia-Velasco JA, Remohí J, Simón C . Endometrial quality in infertile women with endometriosis. Ann N Y Acad Sci. 2001; 943: 122-30. • Simón C , Dominguez F, Remohí J, Pellicer A. Embryo effects in human implantation: embryonic regulation of endometrial molecules in human implantation. Ann N Y Acad Sci. 2001; 943: 1-16. • Garrido N, Albert C, Krüssel JS, O'Connor JE, Remohí J, Simón C , Pellicer A. Expression, production, and secretion of vascular endothelial growth factor and interleukin-6 by granulosa cells is comparable in women with and without endometriosis. Fertil Steril. 2001; 76(3): 568-75. • Requena A, Neuspiller F, Cobo AC, Aragonés M, García-Velasco JA, Remohí J, Simón C , Pellicer A. Endocrinological and ultrasonographic variations after immature oocyte retrieval in a natural cycle. Hum Reprod. 2001; 16(9): 1833-7. • Garcia-Velasco JA, Simón C . Blastocyst transfer: does it really affect the outcome? Curr Opin Obstet Gynecol. 2001; 13(3): 299-304. • Garcia-Velasco JA, Nikas G, Remohí J, Pellicer A, Simón C . Endometrial receptivity in terms of pinopode expression is not impaired in women with endometriosis in artificially prepared cycles. Fertil Steril. 2001; 75(6): 1231-3. • Mercader A, Simón C , Galán A, Herrer R, Albert C, Remohí J, Pellicer A. An analysis of spontaneous hatching in a human endometrial epithelial coculture system: is assisted hatching justified? J Assist Reprod Genet. 2001; 18(6): 315-9. • Aplin JD, Meseguer M, Simón C , Ortíz ME, Croxatto H, Jones CJ. MUC1, glycans and the cell- surface barrier to embryo implantation. Biochem Soc Trans. 2001; 29(Pt 2): 153-6.
38 • Meseguer M, Aplin JD, Caballero-Campo P, O'Connor JE, Martín JC, Remohí J, Pellicer A, Simón C . Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod. 2001; 64(2): 590-601. 2000 • Galán A, Herrer R, Remohí J, Pellicer A, Simón C . Embryonic regulation of endometrial epithelial apoptosis during human implantation. Hum Reprod. 2000; 15 Suppl 6: 74-80. • Rubio C, Simón C , Mercader A, Garcia-Velasco J, Remohí J, Pellicer A. Clinical experience employing co-culture of human embryos with autologous human endometrial epithelial cells. Hum Reprod. 2000; 15 Suppl 6: 31-8. • Tremellen KP, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, Norman RJ, Robertson SA, Simón C . The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod. 2000; 15(12): 2653-8. • González RR, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Pellicer A, Simón C . Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. J Clin Endocrinol Metab. 2000; 85(12): 4883-8. • Martín JC, Jasper MJ, Valbuena D, Meseguer M, Remohí J, Pellicer A, Simón C . Increased adhesiveness in cultured endometrial-derived cells is related to the absence of moesin expression. Biol Reprod. 2000; 63(5): 1370-6. • Garcia-Velasco JA, Isaza V, Requena A, Martínez-Salazar FJ, Landazábal A, Remohí J, Pellicer A, Simón C . High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low responder IVF patients: a prospective, randomized, controlled trial. Hum Reprod. 2000; 15(11): 2292-6. • Simón C , Martín JC, Pellicer A. Paracrine regulators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000; 14(5): 815-26. • Ibérico G, Navarro J, Blasco L, Simón C , Pellicer A, Remohí J. Embryo reduction of multifetal pregnancies following assisted reproduction treatment: a modification of the transvaginal ultrasound-guided technique. Hum Reprod. 2000; 15(10): 2228-33. • Galán A, O'Connor JE, Valbuena D, Herrer R, Remohí J, Pampfer S, Pellicer A, Simón C . The human blastocyst regulates endometrial epithelial apoptosis in embryonic adhesion. Biol Reprod. 2000 Aug;63(2):430-9. Erratum in: Biol Reprod 2001; 64(4): 1283. • Díaz I, Navarro J, Blasco L, Simón C , Pellicer A, Remohí J. Impact of stage III-IV endometriosis on recipients of sibling oocytes: matched case-control study. Fertil Steril. 2000; 74(1): 31-4. • González RR, Simón C , Caballero-Campo P, Norman R, Chardonnens D, Devoto L, Bischof P. Leptin and reproduction. Hum Reprod Update. 2000; 6(3): 290-300. • Requena A, Neuspiller F, Cobo AC, Aragonés M, Remohí J, Simón C , Pellicer A. The potential use of maturation in vitro of human oocytes in low responder patients. J Assist Reprod Genet. 2000; 17(5): 239-44. • Simón C , Pellicer A. Blastocyst transfer for couples with multiple IVF failures? Fertil Steril. 2000; 73(4): 872. • Garrido N, Navarro J, Remohí J, Simón C , Pellicer A. Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update. 2000; 6(1): 67-74. • Vidal F, Rubio C, Simón C , Giménez C, Mínguez Y, Pellicer A, Santaló J, Remohí J, Egozcue J. Is there a place for preimplantation genetic diagnosis screening in recurrent miscarriage patients? J Reprod Fertil Suppl. 2000; 55: 143-6. • Pellicer A, Albert C, Garrido N, Navarro J, Remohí J, Simón C . The pathophysiology of endometriosis-associated infertility: follicular environment and embryo quality. J Reprod Fertil Suppl. 2000; 55: 109-19. • Simón C , Martin JC, Meseguer M, Caballero-Campo P, Valbuena D, Pellicer A. Embryonic regulation of endometrial molecules in human implantation. J Reprod Fertil Suppl. 2000; 55: 43- 53. • Caligara C, Navarro J, Vargas G, Simón C , Pellicer A, Remohí J. Repeated controlled ovarian stimulation and oocyte retrieval rate in donors. Reprod Technol. 2000; 10(5): 248-252. 1999 • Simón C , Landeras J, Zuzuarregui JL, Martín JC, Remohí J, Pellicer A. Early pregnancy losses in in vitro fertilization and oocyte donation. Fertil Steril. 1999; 72(6): 1061-5. • Valbuena D, Jasper M, Remohí J, Pellicer A, Simón C . Ovarian stimulation and endometrial
39 receptivity. Hum Reprod. 1999; 14 Suppl 2: 107-11. • Kohen P, Castro A, Caballero-Campo P, Castro O, Vega M, Makrigiannakis A, Simón C , Carvallo P, Devoto L. Interleukin-1beta (IL-1beta) is a modulator of human luteal cell steroidogenesis: localization of the IL type I system in the corpus luteum. J Clin Endocrinol Metab. 1999; 84(11): 4239-45. • Simón C , Mercader A, Garcia-Velasco J, Nikas G, Moreno C, Remohí J, Pellicer A. Coculture of human embryos with autologous human endometrial epithelial cells in patients with implantation failure. J Clin Endocrinol Metab. 1999; 84(8):2638-46. • Simón C , Valbuena D. Embryonic implantation. Ann Endocrinol (Paris). 1999; 60(2): 134-6. • Pellicer A, Simón C . Relationships in medicine--causal vs. casual. Fertil Steril. 1999; 72(1): 188- 90. • Cobo AC, Requena A, Neuspiller F, Aragon s M, Mercader A, Navarro J, Simón C , Remohí J, Pellicer A. Maturation in vitro of human oocytes from unstimulated cycles: selection of the optimal day for ovum retrieval based on follicular size. Hum Reprod. 1999; 14(7): 1864-8. • Pellicer A, Rubio C, Vidal F, Mínguez Y, Giménez C, Egozcue J, Remohí J, Simón C . In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos. Fertil Steril. 1999; 71(6): 1033-9 • Rubio C, Simón C , Blanco J, Vidal F, Mínguez Y, Egozcue J, Crespo J, Remohí J, Pellicer A. Implications of sperm chromosome abnormalities in recurrent miscarriage. J Assist Reprod Genet. 1999; 16(5): 253-8. • Pellicer A, Garrido N, Albert C, Navarro J, Remohí J, Simón C . Cytokines in older patients undergoing in vitro fertilization: the relationship to the response to controlled ovarian hyperstimulation. J Assist Reprod Genet. 1999; 16(5): 247-52. • Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohí J, Simón C . The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1beta, interleukin-6, and vascular endothelial growth factor. Fertil Steril. 1999; 71(3): 482-9. • Sánchez-Cuenca J, Martín JC, Pellicer A, Simón C . Cytokine pleiotropy and redundancy--gp130 cytokines in human implantation. Immunol Today. 1999; 20(2): 57-9. • Simón C , Martín JC, Galan A, Valbuena D, Pellicer A. Embryonic regulation in implantation. Semin Reprod Endocrinol. 1999; 17(3): 267-74. • Simón C , Pellicer A. Low and high responders- at what levels of serum estradiol do things start to get fuzzy. Fertil Steril. 1999; 71(3): 582-7. 1998 • de los Santos MJ, Anderson DJ, Racowsky C, Simón C , Hill JA. Expression of interleukin-1 system genes in human gametes. Biol Reprod. 1998; 59(6): 1419-24. • Meseguer M, Pellicer A, Simón C . MUC1 and endometrial receptivity. Mol Hum Reprod. 1998; 4(12): 1089-98. • Simón C , Valbuena D, Krüssel J, Bernal A, Murphy CR, Shaw T, Pellicer A, Polan ML. Interleukin- 1 receptor antagonist prevents embryonic implantation by a direct effect on the endometrial epithelium. Fertil Steril. 1998; 70(5): 896-906. • Pellicer A, Ardiles G, Neuspiller F, Remohí J, Simón C , Bonilla-Musoles F. Evaluation of the ovarian reserve in young low responders with normal basal levels of follicle-stimulating hormone using three-dimensional ultrasonography. Fertil Steril. 1998; 70(4): 671-5. • Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohí J, Simón C . The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production. Fertil Steril. 1998; 70(3): 425-31. • Simón C , Garcia Velasco JJ, Valbuena D, Peinado JA, Moreno C, Remohí J, Pellicer A. Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil Steril. 1998; 70(2): 234-9. • Krüssel JS, Simón C , Rubio MC, Pape AR, Wen Y, Huang HY, Bielfeld P, Polan ML. Expression of interleukin-1 system mRNA in single blastomeres from human preimplantation embryos. Hum Reprod. 1998; 13(8): 2206-11. • Moreno C, Ruiz A, Simón C , Pellicer A, Remohí J. Intracytoplasmic sperm injection as a routine indication in low responder patients. Hum Reprod. 1998; 13(8): 2126-9.
40 • Simón C , Moreno C, Remohí J, Pellicer A. Cytokines and embryo implantation. J Reprod Immunol. 1998; 39(1-2): 117-31. • Pellicer A, Gaitán P, Neuspiller F, Ardiles G, Albert C, Remohí J, Simón C . Ovarian follicular dynamics: from basic science to clinical practice. J Reprod Immunol. 1998; 39(1-2): 29-61. • Simón C , Caballero-Campo P, García-Velasco JA, Pellicer A. Potential implications of chemokines in reproductive function: an attractive idea. J Reprod Immunol. 1998; 38(2): 169-93. • Pellicer A, Valbuena D, Bauset C, Albert C, Bonilla-Musoles F, Remohí J, Simón C . The follicular endocrine environment in stimulated cycles of women with endometriosis: steroid levels and embryo quality. Fertil Steril. 1998; 69(6): 1135-41. • Simón C , Moreno C, Remohí J, Pellicer A. Molecular interactions between embryo and uterus in the adhesion phase of human implantation. Hum Reprod. 1998; 13 Suppl 3: 219-32; discussion 233-6. • Castro A, Castro O, Troncoso JL, Kohen P, Simón C , Vega M, Devoto L. Luteal leukocytes are modulators of the steroidogenic process of human mid-luteal cells. Hum Reprod. 1998; 13(6): 1584-9 • Neuspiller F, Levy M, Remohí J, Ruiz A, Simón C , Pellicer A. The use of long- and short-acting forms of gonadotrophin-releasing hormone analogues in women undergoing oocyte donation. Hum Reprod. 1998; 13(5): 1148-51. • Vidal F, Giménez C, Rubio C, Simón C , Pellicer A, Santaló J, Egozcue J. FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage. J Assist Reprod Genet. 1998; 15(5): 310-3. • Krüssel JS, Huang HY, Simón C , Behr B, Pape AR, Wen Y, Bielfeld P, Polan ML. Single blastomeres within human preimplantation embryos express different amounts of messenger ribonucleic acid for beta-actin and interleukin-1 receptor type I. J Clin Endocrinol Metab. 1998; 83(3): 953-9. • Simón C , Rubio C, Vidal F, Gimenez C, Moreno C, Parrilla JJ, Pellicer A. Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage. Reprod Fertil Dev. 1998; 10(1): 87-92. 1997 • Gartner B, Moreno C, Marinaro A, Remohí J, Simón C , Pellicer A. Accidental exposure to daily long-acting gonadotrophin-releasing hormone analogue administration and pregnancy in an in- vitro fertilization cycle. Hum Reprod. 1997; 12(11): 2557-9. • Mínguez Y, Rubio C, Bernal A, Gaitán P, Remohí J, Simón C , Pellicer A. The impact of endometriosis in couples undergoing intracytoplasmic sperm injection because of male infertility. Hum Reprod. 1997; 12(10): 2282-5. • Raga F, Bauset C, Remohi J, Bonilla-Musoles F, Simón C , Pellicer A. Reproductive impact of congenital Müllerian anomalies. Hum Reprod. 1997; 12(10): 2277-81. • Remohí J, Ardiles G, García-Velasco JA, Gaitán P, Simón C , Pellicer A. Endometrial thickness and serum oestradiol concentrations as predictors of outcome in oocyte donation. Hum Reprod. 1997; 12(10): 2271-6. • Valbuena D, Pellicer A, Guanes PP, Remohí J, Simón C . Effect of disruption versus continuation of gonadotrophin-releasing agonist after human chorionic gonadotrophin administration on corpus luteum function in patients undergoing ovulation induction for in-vitro fertilization. Hum Reprod. 1997; 12(10): 2118-22. • Simón C , Gimeno MJ, Mercader A, O'Connor JE, Remohí J, Polan ML, Pellicer A. Embryonic regulation of integrins beta 3, alpha 4, and alpha 1 in human endometrial epithelial cells in vitro. J Clin Endocrinol Metab. 1997; 82(8): 2607-16. • Ruiz A, Remohí J, Minguez Y, Guanes PP, Simón C , Pellicer A. The role of in vitro fertilization and intracytoplasmic sperm injection in couples with unexplained infertility after failed intrauterine insemination. Fertil Steril. 1997; 68(1): 171-3. • Cano F, García-Velasco JA, Millet A, Remohí J, Simón C , Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet. 1997; 14(5): 254-61. • Remohí J, Gartner B, Gallardo E, Yalil S, Simón C , Pellicer A. Pregnancy and birth rates after oocyte donation. Fertil Steril. 1997; 67(4): 717-23. • Blanco J, Rubio C, Simón C , Egozcue J, Vidal F. Increased incidence of disomic sperm nuclei in
41 a 47,XYY male assessed by fluorescent in situ hybridization (FISH). Hum Genet. 1997; 99(3): 413-6. • Simón C , Mercader A, Gimeno MJ, Pellicer A. The interleukin-1 system and human implantation. Am J Reprod Immunol. 1997; 37(1): 64-72. • Simón C , García-Velasco JA , Caballero-Campo P, Polan ML. Cytokines and reproductive function. Current Opinion in Endocrinology and Diabetes. 1997; 4: 377-86. 1996 • Simón C , Mercader A, Frances A, Gimeno MJ, Polan ML, Remohí J, Pellicer A. Hormonal regulation of serum and endometrial IL-1 alpha, IL-1 beta and IL-1ra: IL-1 endometrial microenvironment of the human embryo at the apposition phase under physiological and supraphysiological steroid level conditions. J Reprod Immunol. 1996; 31(3): 165-84. • Remohí J, Gallardo E, Levy M, Valbuena D, de los Santos MJ, Simón C , Pellicer A. Oocyte donation in women with recurrent pregnancy loss. Hum Reprod. 1996; 11(9): 2048-51. • Valbuena D, Simón C , Romero JL, Remohí J, Pellicer A. Factors responsable for multiple pregnancies after ovarian stimulation and intrauterine insemination with gonadotropins. J Assist Reprod Genet. 1996; 13(8): 663-8. • Guanes PP, Remohí J, Gallardo E, Valbuena D, Simón C , Pellicer A. Age does not affect uterine resistance to vascular flow in patients undergoing oocyte donation. Fertil Steril. 1996; 66(2): 265- 70. • Gallardo E, Simón C , Levy M, Guanes PP, Remohí J, Pellicer A. Effect of age on sperm fertility potential: oocyte donation as a model. Fertil Steril. 1996; 66(2): 260-4. • Simón C . Potential molecular mechanisms for the contraceptive control of implantation. Mol Hum Reprod. 1996; 2(7): 475-9. • Pellicer A, Valbuena D, Cano F, Remohí J, Simón C . Lower implantation rates in high responders: evidence for an altered endocrine milieu during the preimplantation period. Fertil Steril. 1996; 65(6): 1190-5. • Simón C , Gimeno MJ, Mercader A, Francés A, Garcia Velasco J, Remohí J, Polan ML, Pellicer A. Cytokines-adhesion molecules-invasive proteinases. The missing paracrine/autocrine link in embryonic implantation? Mol Hum Reprod. 1996; 2(6): 405-24. • De los Santos MJ, Mercader A, Francés A, Portolés E, Remohí J, Pellicer A, Simón C . Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development. Biol Reprod. 1996; 54(3): 563-74. • Simón C , García-Velasco JA, Polan ML. Cytokines and reproductive function. Current Opinion in Endocrinology and Diabetes. 1996; 3: 463-71. • Simón C , Tsafriri A, Pellicer A, Polan ML. The role of interleukins in the ovary. Reproductive Medicine Review. 1996; 5(1): 51-63. 1995 • Pellicer A, Oliveira N, Ruiz A, Remohí J, Simón C . Exploring the mechanism(s) of endometriosis- related infertility: an analysis of embryodevelopment and implantation in assisted reproduction. Hum Reprod. 1995; 10 Suppl 2: 91-7. • Remohí J, Gallardo E, Guanes PP, Simón C , Pellicer A. Donor-recipient synchronization and the use of gonadotrophin-releasing hormone agonists to avoid the premature luteinizing hormone surge in oocyte donation. Hum Reprod. 1995; 10 Suppl 2: 84-90. • Pellicer A, Simón C , Remohí J. Effects of aging on the female reproductive system. Hum Reprod. 1995; 10 Suppl 2: 77-83. • Simón C , Pellicer A, Polan ML. Interleukin-1 system crosstalk between embryo and endometrium in implantation. Hum Reprod. 1995; 10 Suppl 2 :43-54. • Polan ML, Simón C , Frances A, Lee BY, Prichard LE. Role of embryonic factors in human implantation. Hum Reprod. 1995; 10 Suppl 2: 22-9. • Simón C , Mercader A, Portolés E, Francés A, Pellicer A. [The interleukin-1 system during human implantation]. Contracept Fertil Sex. 1995; 23(10): 626-30. • Cano F, Simón C , Remohí J, Pellicer A. Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. Fertil Steril. 1995; 64(3): 584-9. • Simón C , Frances A, Lee BY, Mercader A, Huynh T, Remohi J, Polan ML, Pellicer A. Immunohistochemical localization, identification and regulation of the interleukin-1 receptor
42 antagonist in the human endometrium. Hum Reprod. 1995; 10(9): 2472-7. • Simón C , Cano F, Valbuena D, Remohí J, Pellicer A. Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients. Hum Reprod. 1995; 10(9): 2432-7. • Remohí J, Gutiérrez A, Cano F, Ruiz A, Simón C , Pellicer A. Long oestradiol replacement in an oocyte donation programme. Hum Reprod. 1995; 10(6): 1387-91. • Simón C , Francés A, Pellicer A, Polan ML. Cytokines in Implantation. Semin Reprod Endocr. 1995; 13: 142-51. 1994 • Simón C , Tsafriri A, Chun SY, Piquette GN, Dang W, Polan ML. Interleukin-1 receptor antagonist suppresses human chorionic gonadotropin-induced ovulation in the rat. Biol Reprod. 1994; 51(4): 662-7. • Piquette GN, Simón C , el Danasouri I, Frances A, Polan ML. Gene regulation of interleukin-1 beta, interleukin-1 receptor type I, and plasminogen activator inhibitor-1 and -2 in human granulosa-luteal cells. Fertil Steril. 1994; 62(4): 760-70. • Piquette GN, Tilly JL, Prichard LE, Simón C , Polan ML. Detection of apoptosis in human and rat ovarian follicles. J Soc Gynecol Investig. 1994; 1(4): 297-301. • Simón C , Polan ML. Cytokines and reproduction. West J Med. 1994; 160(5): 425-9. • Pellicer A, Marí M, de los Santos MJ, Simón C , Remohí J, Tarín JJ. Effects of aging on the human ovary: the secretion of immunoreactive alpha-inhibin and progesterone. Fertil Steril. 1994; 61(4): 663-8. • Simón C , Gutiérrez A, Vidal A, de los Santos MJ, Tarín JJ, Remohí J, Pellicer A. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994; 9(4): 725-9. • Simón C , Frances A, Piquette G, Hendrickson M, Milki A, Polan ML. Interleukin-1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/paracrine function. J Clin Endocrinol Metab. 1994; 78(4): 847-54. • Simón C , Piquette GN, Frances A, el-Danasouri I, Irwin JC, Polan ML. The effect of interleukin-1 beta (IL-1 beta) on the regulation of IL-1 receptor type I messenger ribonucleic acid and protein levels in cultured human endometrial stromal and glandular cells. J Clin Endocrinol Metab. 1994; 78(3): 675-82. • Simón C , Frances A, Piquette G, Polan ML. Immunohistochemical localization of the interleukin-1 system in the mouse ovary during follicular growth, ovulation, and luteinization. Biol Reprod. 1994; 50(2): 449-57. • Simón C , Frances A, Piquette GN, el Danasouri I, Zurawski G, Dang W, Polan ML. Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist. Endocrinology. 1994; 134(2): 521-8. • Simón C . Editorial: A Critical Role for Interleukin-1 (IL-1) and the type 1 IL-1 receptor in blastocyst implantation. Endocrinology. 1994; 134: 519-20. • Gutiérrez A, Oliveira N, Cano F, Ruiz A, Simón C , Remohí J, Pellicer A. In Vitro Fertilization in Infertile Patients with Endometriosis. Assist Reprod Rev. 1994; 4: 162-71. 1993 • Simón C , Piquette GN, Frances A, Polan ML. Localization of interleukin-1 type I receptor and interleukin-1 beta in human endometrium throughout the menstrual cycle. J Clin Endocrinol Metab. 1993; 77(2): 549-55. • Simón C , Piquette GN, Frances A, Westphal LM, Heinrichs WL, Polan ML. Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle. Fertil Steril. 1993; 59(4): 791-6. • Bonilla-Musoles F, Ballester MJ, Simón C , Serra V, Raga F. Is avoidance of surgery possible in patients with perimenopausal ovarian tumors using transvaginal ultrasound and duplex color Doppler sonography? J Ultrasound Med. 1993; 12(1): 33-9. 1992 • Simón C , Gómez E, Mir A, De los Santos MJ, Pellicer A. Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. Fertil Steril. 1992; 58(2): 284-9. • Bonilla-Musoles F, Simón C , Serra V, Sampaio M, Pellicer A. An assessment of hysterosalpingosonography (HSSG) as a diagnostic tool for uterine cavity defects and tubal
43 patency. J Clin Ultrasound. 1992; 20(3): 175-81. • Raga F, Simón C , Strasser J, Bonilla-Musoles F. Abdominal, perineal and vaginal sonographic diagnosis of cervix insufficiency. Ultraschall Med. 1992; 13(1): 24-7. 1991 • Simón C , Martinez L, Pardo F, Tortajada M, Pellicer A. Müllerian defects in women with normal reproductive outcome. Fertil Steril. 1991; 56(6): 1192-3. • Bonilla-Musoles F, Pardo G, Sampaio M, Simón C , Fernandes H, Matallín P, Blanes J. Immunisierüngstherapie mit einer neuen vakzine. Therapiewoche Schweiz. 1991; 12: 859-64. 1990 • Simón C , Raga F, Strasser J, Bonilla-Musoles F. [Hysterosalpingography: synechiae? Gartner's ducts?]. Geburtshilfe Frauenheilkd. 1990; 50(12): 977-81. • Bonilla-Musoles F, Pardo G, Simón C . How accurate is ultrasonography in monitoring IUD placement? J Clin Ultrasound. 1990; 18(5): 395-9. • Bonilla-Musoles F, Sampaio M, Simón C , Serra V, Strasser J. [Pathology of the yolk sac: endosonographic results]. Ultraschall Med. 1990; 11(1): 24-8. 1989 • Bonilla-Musoles F, Pardo G, Sampaio M, Pellicer A, Simón C , Strasser J. [Vaginal endosonography in extrauterine pregnancy]. Ultraschall Med. 1989; 10(4): 215-21. • Pellicer A, Simón C , Miró F, Castellví RM, Ruiz A, Ruiz M, Pérez M, Bonilla-Musoles F. Ovarian response and outcome of in-vitro fertilization in patients treated with gonadotrophin-releasing hormone analogues in different phases of the menstrual cycle. Hum Reprod. 1989; 4(3): 285-9. • Bonilla-Musoles F, Monmeneu RM, Simón C , Serra V. Can the uterine cervix grow a moustache? Eur J Gynaecol Oncol. 1989; 10(2): 145-6. 1987 • Bonilla-Musoles F, Monmeneu S, Pardo G, Simón C , Serra V, Pellicer A. Granular cell myoblastoma (GCM): contribution of three cases with genital involvement. Eur J Gynaecol Oncol. 1987; 8(2): 110-4. • Bonilla-Musoles F, Castells A, Simón C , Serra V, Pellicer A, Ramírez A, Pardo G. Importance of Langerhans cells in the immune origin of carcinoma of the uterine cervix. Eur J Gynaecol Oncol. 1987; 8(1): 44-60. 1985 • Bonilla-Musoles F, Pellicer A, Perez Gil M, Simón C , Meyer A. [Has intrauterine surgery using ultrasound a future?]. Ultraschall Med. 1985; 6(4): 208-14.
Peer Reviewed Articles in National Journals
2007 • Sánchez-Luengo S, Simón C . Tratamiento con células madre. Anales de Pediatría Continuada. 2007; 5(3): 172-175. 2006 • Simón C , Pellicer A. Encuentro de expertos sobre gestaciones múltiples. Rev Iberoam Fertil Reprod Hum. 2006; 22(5): 309-337. • Marqueta J, Cabello Y, Hernández J, Coroleu B, Simón C , Pérez-Milán F, Arnott I, Blanes R, Monzó A, Matorras R. Registro FIV-ICSI de la Sociedad Española de Fertilidad. Año 2002. Rev Iberoam Fertil Reprod Hum. 2006; 23(2): 87-96. 2005 • Marqueta J, Cabello Y, Hernández J, Coroleu B, Simón C , Pérez-Milán F, Arnott I, Blanes R, Monzó A, Matorras R. Registro FIV-ICSI de la Sociedad Española de Fertilidad. Año 2001. Rev Iberoam Fertil Reprod Hum. 2005; 24(4): 237-248. • Simón C . Regeneración de células germinales: ¿una quimera? Actualidad y controversias en ginecología nº 5, la opinión de los expertos nº 17. 2005; 5: 3-5. • Simón C , Pellicer A. Patrón proteómico secretado por blastocistos viables como una posible arma diagnóstica para obtener embarazos únicos después de fecundación in Vitro. Rev Iberoam Fertil Reprod Hum. 2005; 22(5): 327-38. 2004 • Cervero A, Horcajadas JA, Martín J, Pellicer A, Simón C . Beca de investigación S.E.F 2001: El
44 sistema de la leptina durante la receptividad endometrial y el desarrollo preimplantatorio. Rev Iberoam Fertil Reprod Hum. 2004; XXV Congreso Nacional SEF: 109-19. • Galán A, Simón C . Regeneración germinal a partir de células madre embrionarias. Rev Iberoam Fertil Reprod Hum. 2004; XXV Congreso Nacional SEF: 173-8. • Martín J, Rubio C, Mercader A, Simón C , Remohí J, Pellicer A. Diagnóstico Genético Preimplantacional dirigido al estudio de enfermedades monogénicas. Rev Iberoam Fertil Reprod Hum. 2004; XXV Congreso Nacional SEF: 179-86 • Pellicer A, Simón C . Fallo repetido de implantación: Aspectos clínicos. Rev Iberoam Fertil Reprod Hum. 2004; XXV Congreso Nacional SEF: 192-6. • Martínez-Conejero JA, Garrido N, Simón C , Pellicer A, Remohí J, Meseguer M. MUC-1 e IL-6: Posibles Marcadores de Fertilidad en Reproducción Humana. Revisión. ASEBIR. 2004; 9(1): 12- 22. ••• Rubio C, Rodrigo L, Mercader A, Mateu E, Simón C , Remohí J, Pellicer A. El diagnóstico genético preimplantacional y sus nuevas indicaciones en reproducción asistida. Clin Invest Gin Obst. 2004; 31(9): 314-22. 2003 • Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. Criopreservación en semen: parámetros que afectan a la supervivencia del espermatozoide. Temas de actualidad en Andrología. 2003; III: 245-66. • Simón C , García-Velasco J.A. Endometriosis y reproducción asistida. Prog Obstet Ginecol. 2003; 46(S1): 95-8. • Meseguer M, Martínez-Conejero JA, Aplin JD, Remohí J, Pellicer A, Simón C . TGF- β1 regula in vitro a la mucina endometrial humana MUC1 durante la implantación embrionaria. Rev Iberoam Fertil Reprod Hum. 2003; 20(3): 167-76. (Premio al mejor artículo básico del año 2003) 2002 • Meseguer M, Garrido de Lomas J, Gimeno C, Bellver J, Simón C , Pellicer A, Remohí J. Presencia del virus de inmunodeficiencia humana y el virus de la hepatitis C en el semen lavado: ¿ausentes o presentes pero no infectivos?. Rev Iberoam Fertil Reprod Hum. 2002; 24: 128-135.
• Garrido N, Meseguer M, Gámiz P, Simón C , Pellicer A, Remohí J. Factor Masculino y técnicas de Reproducción Asistida. ASEBIR. 2002; 7(1): 10-24. • Muñoz E.A, García-Velasco J, Scheffer B, Muñoz M, Remohí J, Pellicer A, Simón C . El uso de FSH recombinante a dosis de 100 UI por día alcanza resultados similares a 150 UI en inseminación intrauterine (IU). Rev Iberoam Fertil Reprod Hum. 2002; 19(4): 253-9. • Garrido N, Meseguer M, Simón C , Pellicer A, Remohí J. Factores influyentes en los resultados de la congelación y descongelación del semen humano. ASEBIR. 2002; 7(2): 21-7. ••• Zuzuarregui JL, Garrido N, Meseguer M, Simón C , Pellicer A, Remohí J. Parámetros que afectan a los resultados de la inseminación artificial con semen de donante. Rev Iberoam Fertil Reprod Hum. 2002; 19(6): 387-97. 2001 • Domínguez F, Martín J, Remohí J, Pellicer A, Simón C . Impronta genómica. Un mecanismo fisiológico de silenciamiento de genes. Rev Iberoam Fertil Reprod Hum. 2001; XVII(6): 289-98. • Remohí J, Muñoz E, Gaytán J, Navarro J, Simón C , Pellicer A. Evaluación de la pareja estéril. Salud Total de la Mujer. 2001; 3: 144-54. • Garrido N, Meseguer M, Simón C , Pellicer A, Remohí J. Detección del virus de la Hepatitis C en semen lavado de varones seropositivos para su posterior uso en reproducción asistida: resultados preliminares. Actualidad Andrológica. 2001; 9(2-3): 56-60. • Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. ¿Es segura la utilización del semen de donante? Seguimiento de enfermedades infecciosas y desórdenes hereditarios en la población de donantes de semen y el programa de IAD; experiencia de 10 años. Actualidad Andrológica. 2001; 9(2-3): 61-7. • González I, Bosch E, Camargo F, Caligara C, Simón C , Pellicer A, Remohí J. Efecto del uso previo de los anticonceptivos hormonales orales sobre la estimulación ovárica controlada. Rev Iberoam Fertil Reprod Hum. 2001; 18(6): 455-9. • Ramos-González P, García-Velasco J.A, Villasante A, Scheffer B, Remohí J, Pellicer A, Simón C . Transferencia de embriones: la gran olvidada. Rev Iberoam Fertil Reprod Hum. 2001; 18(6): 435-
45 42. • Escudero E, Valbuena D, Remohí J, Simón C , Pellicer A. Repercusión de los altos niveles de estrógeno en la fase de implantación embrionaria. Obst y Ginecol Españ. 2001; X: 101-107. 2000 • Muñoz E, Valbuena D, Landazábal A, Remohí J, Pellicer A, Simón C . Infección por el virus de la hepatitis C y embarazo. Revisión de conjunto. Prog Obstet Ginecol. 2000; 43: 105-16. • Ibérico G, Crespo J, Serra V, Lara V, Muñoz E, Simón C , Pellicer A, Remohí J. Síndrome antifosfolipídico y reproducción asistida: a propósito de un caso. Rev Iberoam Fertil Reprod Hum. 2000; XVII(2): 167-74. • González R.R, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Bishof P, Simón C . La leptina: un nuevo factor regulador de la implantación humana. Rev Iberoam Fertil Reprod Hum. 2000; XVII(4): 59-74. • Landazábal A, Valbuena D, Remohí J, Pellicer A, Simón C . Estrategias de mejora de la implantación embrionaria. Cienc Ginecol. 2000; 4: 191-8. • Vidal C, Romero J, Rubio C, Pérez-Cano I, Ruiz A, Navarro J, Simón C , Pellicer A, Remohí J. Indicaciones clínicas de la microinyección intracitoplasmática de espermatozoides (ICSI). Cienc Ginecol. 2000; 4: 177-84. • Caligara C, Moreno C, Valbuena D, Mercader A, Navarro J, Remohí J, Pellicer A, Simón C . El desarrollo embrionario preimplantatorio tras FIV es superior a ICSI debido a la calidad espermática y no a la técnica. Prog Obstet Ginecol. 2000; 43: 303-9. • Bellver J, Navarro J, Albert C, Simón C , Pellicer A, Remohí J. Curso natural, clínica, diagnóstico, fisiopatología y factores de riesgo. Folia Clin Obstet Ginec. 2000; 24: 10-34. • Ibérico G, Vergara F, Navarro J, Vargas G, Remohí J, Pellicer A, Simón C . Caso clínico: Acumulación de líquido en cavidad endometrial e hidrosálpinx. Rev Iberoam Fertil Reprod Hum. 2000; XVII(5): 251-6. • Cuneo S, Camargo F, Vargas G, Caligara C, Pellicer A, Simón C , Remohí J. Importancia del diagnóstico de la fibrosis quística asociada a agenesia congénita de los conductos deferentes y del adecuado tratamiento de la infertilidad masculina para evitarla en la descendencia. Rev Iberoam Fertil Reprod Hum. 2000; XVII(5): 219-23. 1999 • Díaz I, Navarro J, Torres JV, Simón C , Pellicer A, Remohí J. Donación de ovocitos: Indicaciones y Resultados. Rev Iberoam Fertil Reprod Hum. 1999; XVI(2): 121-6. • Ibérico G, Simón C , Remohí J, Pellicer A. Diálogo endometrio materno embrión: como mejorar la implantación embrionaria en FIV. Rev Iberoam Fertil Reprod Hum. 1999; XVI(2): 141-9. • Vergara F, Muñoz E, Alvarez J.C, Simón C , Remohí J, Pellicer A. Metformina y troglitazona en el sindrome de ovario poliquístico. Rev Iberoam Fertil Reprod Hum. 1999; XVI(3). 175-82. • Muñoz E, Alvarez J.C, Landazábal A, Díaz I, Crespo J, Simón C , Pellicer A, Remohí J. Síndrome de hiperestimulación ovárica y accidentes cerebrovasculares: A propósito de un caso. Rev Iberoam Fertil Reprod Hum. 1999; XVI(3): 239-44. • Alvarez J.C, Navarro J, Crespo J, Rodríguez M, Vergara F, Díaz I, Bonilla F, Simón C , Pellicer A, Remohí J. Embarazo ectópico ovárico momificado y gestación tripe con gemelos monocigóticos tras la transferencia de cinco embriones en estadio de blastocisto. A propósito de un caso. Rev Iberoam Fertil Reprod Hum. 1999; XVI(3): 245-48. • García Velasco JA, Martínez-Salazar J, Requena A, Caballero P, Remohí J, Pellicer A, Simón C . Implicaciones hormonales que comprometen la implantación. Rev Iberoam Fertil Reprod Hum. 1999; XVI(5): 327-34. • García-Velasco J.A, Martínez-Salazar FJ, Requena A, Simón C , Pellicer A, Remohí J. Reproducción asistida y el síndrome de inmunodeficiencia adquirida. Medicina Reproductiva. 1999; 2: 38-46. • Garrido N, Albert C, Remohí J, Simón C , Pellicer A. Microambiente autocrino y paracrino folicular y calidad embrionaria en mujeres con endometriosis. Rev Iberoam Fertil Reprod Hum. 1999; XVI(6): 413-8. • Albert C, Garrido N, Mercader A, Remohí J, Simón C , Pellicer A. Fisiopatología del Síndrome de Hiperestimulación Ovárica: Implicación del endotelio. Rev Iberoam Fertil Reprod Hum. 1999; XVI(6): 455-63. 1998
46 • García-Velasco J.A, Valbuena D, Simón C , Remohí J, Pellicer A. La alta respuesta en FIV. Rev Iberoam Fertil Reprod Hum. 1998; XV(3): 247-52. • Rubio C, Mínguez Y, Romer JL, Ruiz A, Cobo A, Simón C , Pellicer A, Remohí J. Diagnóstico preimplantatorio de enfermedades ligadas al sexo: indicaciones y resultados preliminares. Obst y Ginecol Españ. 1998; VII: 7-11. • Neuspiller F, Ardiles G, Yalil S, Simón C , Pellicer A, Remohí J. Resultados de ICSI en azoospermia obstructiva. Obst y Ginecol Españ. 1998; VII: 29-35. • Cobo A, Ruiz A, Bernal A, Romero J, Rubio C, Mínguez Y, Molero MD, Simón C , Pellicer A, Remohí J. Fecundación y desarrollo embrionario tras la ICSI de ovocitos madurados in vitro. Obst y Ginecol Españ. 1998; VII: 117-22. • Remohí J, Neuspiller F, Ardiles G, Yalil S, Simón C , Pellicer A. Azoospermias secretoras; posibilidades terapéuticas actuales. Obst y Ginecol Españ. 1998; VII: 123-26. • Nuñez R, Caballero P, Remohí J, Simón C , Pellicer A, Bonilla-Musoles F. Bancos de semen en la era del ICSI. Obst y Ginecol Españ. 1998; VII: 127-34. • Landeras J, Martínez-Salazar FJ, García-Velasco JA, Levy M, Simón C , Pellicer A, Remohí J. Posibilidades reproductivas tras vasectomía. Obst y Ginecol Españ. 1998, VII: 135-38. • Ardiles G, Neuspiller F, Guaman W, Moreno C, Simón C , Pellicer A, Remohí J. Inseminación Artificial conyugal en mujeres mayores de 35 años. Obst y Ginecol Españ. 1998; VII: 165-68 • Mercader A, Herrer R, Valbuena D, Remohí J, Simón C . Cocultivo embrionario. Rev Iberoam Fertil Reprod Hum. 1998; XV(4): 283-7. • Galán A, Pellicer A, Simón C . Apoptosis y reproducción. Rev Iberoam Fertil Reprod Hum. 1998; XV(4): 307-15. • Mercader A, Simón C , Herrer R, Albert C, Galán A, Remohí J, Pellicer A. Estudio del desarrollo en embriones cocultivados con células del epitelio endometrial humano. Arch. Esp. Morfol. 1998; 3: 113-8. 1997 • Yalil S, García-Velasco J.A, Silvestri I, Levy M, Minguez Y, Simón C , Remohí J, Pellicer A. Microinyección intracitoplasmática de espermatozoides en fallo de fecundación en FIV. Obst Ginecol Españ. 1997; VI: 5-8. • Caballero P., García Velasco J.A., Pellicer A, Simón C . Quimoquinas una atrayente familia de mediadores específicos. Prog Obst Gin. 1997; 40: 525-37. • Levy M, García-Velasco J.A, Gallardo E, Yalil S, Guanes J.J, Landeras J, Remohí J, Simón C , Pellicer A. Incidencia de embarazo ectópico en las diferentes técnicas de reproducción asistida (TRA). Prog Obst Gin. 1997; 40: 413-8. • Amorocho B, De los Santos M.J, Rubio M.C, Mínguez Y, Ballesteros A, Simón C , Remohí J, Pellicer A, Gómez E. Efectos de la microinyección espermática en la congelación de embriones. Obst Ginecol Españ. 1997; VI: 97-9. • Neuspiller F, Rubio C, Mínguez Y, Simón C , Pellicer A, Remohí J. Inyección intracitoplasmática de espermatozoides -ICSI- en casos extremos. Rev. Lat. Amer. Est. Fert. 1997; 11(1): 21-9. • Neuspiller F, Ardiles G, Yalil S, Simón C , Pellicer A, Remohí J. Resultado de la ICSI en azoospermias obstructivas. Rev. Lat. Amer. Est. Fert. 1997; 11(2): 51-9. ••• Moreno C, Simón C , Pellicer A, Remohí J. Donación de ovocitos como opción reproductiva en pacientes con disgenesia gonadal. Rev. Lat. Amer. Est. Fert. 1997; 11: 94-100. 1996 • Valbuena D, Cano F, Simón C . La ventana de implantación. Rev Iberoam Fertil Reprod Hum. 1996; XIII(2): 127-32. • Rubio C, Remohí J, Pellicer A, Simón C . Diagnóstico preimplantatorio. Biopsia embrionaria y técnicas de análisis genético. Rev Iberoam Fertil Reprod Hum. 1996; XIII(3): 151-9. • Remohí J, Gallardo E, Guanes PP, Gartner B, Simón C y Pellicer A. Nuevos enfoques en la donación de ovocitos. Rev. Lat. Amer. Est. Fert. 1996; 10(2): 51-63. • Gallardo E, Guanes PP, Levy M, Simón C , Pellicer A y Remohí J. Donación de ovocitos: resultados de 5 años de experiencia en el Instituto Valenciano de Infertilidad. Obst Ginecol Españ. 1996; V: 89-97. • Gallardo E, Guanes PP, Valbuena D, Yalil S, Simón C , Pellicer A y Remohí J. La utilidad de la inyección intracitoplasmática de espermatozoides (ICSI) en la donación de ovocitos. Obst Ginecol Españ. 1996; V: 125-9.
47 • Cobo A.C, Rubio M.C, Minguez Y, Ruiz A, Romero J, Simón C , Pellicer A, Remohí J. ICSI y espermatozoides de eyaculado. Solución a la esterilidad de origen masculino. Obst Ginecol Españ. 1996; V: 99-103. 1995 • Romero J, De los Santos MJ, Ruiz A, Rubio MC, Mínguez Y, Simón C , Remohí J, Pellicer A. Morfología del acrosoma anómala: nueva indicación para ICSI. Rev Iberoam Fertil Reprod Hum. 1995; XII(1): 61-3. • Pellicer A., Guanes P.P., Simón C . Tratamiento del hiperandrogenismo sin deseo reproductivo. • Prog Obst Gin. 1995; 38(supl 1): S127-S143. • Gutiérrez A, Gallardo E, Cano F, Romero JL, Simón C , Pellicer A, Remohí J. Donación de ovocitos: influencia de la edad de la receptora en los resultados clínicos. Prog Obst Gin. 1995; 38: 327-32. • Simón C y Cano F. Fisiopatología, inmunología y endometriosis. Rev Iberoam Fertil Reprod Hum. 1995; XII(4): 259-66. • Oliveira N, Pellicer A, Remohí J, Cano F, Simón C . Alteración del desarrollo embrionario precoz en pacientes con endometriosis. Prog Obst Gin. 1995; 38: 465-70. 1994 • Mercader A y Simón C . Citokinas en la implantación. Obstet Ginecol Españ. 1994; III: 149-53.
• Simón C . Fisiología de la Implantación. Obstet Ginecol Españ. 1994; III: 135-141. 1992 • Bonilla-Musoles F, Ballester MJ, Raga F, Serra V, Simón C . Aplicaciones del Doppler Duplex Color Transvaginal en Obstetricia y Ginecología. Rev Fed Centroam Soc Obst Ginec. 1992; 2: 9- 22. • Simón C , Bonilla-Musoles F, Pellicer A. Etiopatogenia de la endometriosis. Aspectos Inmunológicos. Revisión de conjunto. Obstet Ginecol Españ. 1992; II. 105-8. 1991 • Simón C , Matallín P, Martorell M, Torres JV. Citometría de flujo en el carcinoma verrucoso vulvar. Clin Invest Gin Obst. 1991; 18(9): 366-9. • Matallín P, Martorell MA, Torres JV, Simón C . Citometría de flujo en melanomas malignos vulvares. Clin Invest Gin Obst. 1991; 18(5): 172-7. • Simón C , Pellicer A, Millet A. Tomografía axial computarizada versus resonancia magnética nuclear en el diagnóstico de la patología hipofisaria. Clin Invest Gin Obst. 1991; 18(3): 88-91. • Simón C , Tarín J, Gómez E, Remohí J, Bonilla-Musoles F, Pellicer A. Comparación entre distintos protocolos de estimulación ovárica en un programa FIV. Obstet Ginecol Españ. 1991; I: 85-9. • Simón C , Millet A, Losada J, Pellicer A. Inducción de una gestación con análogos de la GnRH y gonadotrofinas en una paciente con fallo ovárico precoz. Rev Iberoam Fertil Reprod Hum. 1991; VIII(2): 95-7 1990 • Tarín J, Simón C , Bonilla-Musoles F, Pellicer A. Efectos del tabaco en ovocitos humanos: Análisis citogenético. Obst Ginec Españ. 1990; I. 38-42. 1989 • Matallín P, Torres JV, Martorell M, Simón C . Transformación maligna del quiste de ovario. A propósito de dos casos de carcinomas epidermoides desarrollados sobre quistes dermoides de ovario. Rev Esp Obst y Gin. 1989; 48: 291-6. • Bonilla-Musoles F, Sampaio M, Simón C , Raga F. Posibilidades de diagnóstico precoz en el cáncer de ovario. Rev Esp Obst y Gin. 1989; 48: 81-95. • Bonilla-Musoles F, Sampaio M, Vilela M, Simón C , Serra V, Fernandes H. Ultrasonidos en incontinencia urinaria. Rev Esp Obst y Gin. 1989; 48: 139-48. • Simón C , Sampaio M, Pardo G, Matallín P, Bonilla-Musoles F. Tratamiento conservador del embarazo ectópico. Revisión de conjunto. Rev Esp Obst y Gin. 1989; 48: 43-50. • Bonilla-Musoles F, Pardo G, Simón C , Sampaio M, Pellicer A. Alternativas actuales a la fertilización in vitro y transferencia de embriones. Importancia de la endosonografia vaginal. Rev Esp Obst y Gin. 1989; 48. 7-18 • Simón C , Pellicer A, Millet A, Navarro S, Navarro E, Tortajada M, Bonilla-Musoles F. Gestación
48 ovárica en portadora de dispositivo intrauterino (DIU). Caso clínico. Rev Iberoam Fertil Reprod Hum. 1989; VI(2): 139-42. 1988 • Bonilla-Musoles F, Serra V, Pardo G, Simón C , Ramírez A. Condiloma atípico del cuello uterino. Clin Ginecol. 1988; 12/1. 13-42. 1987 • Simón C , Bonilla-Musoles F. Tabaco y cáncer de cérvix. Rev Esp Obst y Gin. 1987; 46. 391-404.
1986 • Simón C , Martínez-Ramón A, Serra V, Tortajada M, Bonilla-Musoles F. Biopsia Corial Alternativa de diagnóstico precoz en el primer trimestre del embarazo. Rev Esp Obst y Gin. 1986; 45: 645- 56. • Bonilla-Musoles F, Castells A, Serra V, Simón C , Pellicer A, Pardo G. Importancia de las células de Langerhans en el origen inmunológico del cáncer de cerviz uterino. Obst y Gin Lat Amer. 1986; 44. 81-96 1985 • Bonilla-Musoles F, Pardo G, Simón C , Serra V, Remohí J. Ensayo clínico del tratamiento monodosis con comprimidos vaginales de clotrimazol 500 mg en micosis vaginales. Rev Esp Obst y Gin. 1985; 44: 589-602. • Bonilla-Musoles F, Legua V, Ramírez JV, Remohí J, Blanes J, Ruiz A, Serra V, Simón C , Pellicer A. El condiloma del cuello uterino I. Etiopatogenia y Epidemiología. Progr Obstet Ginecol. 1985; 28(8): 493-504. • Bonilla-Musoles F, Legua V, Ramírez JV, Remohí J, Blanes J, Ruiz A, Serra V, Simón C , Pellicer A. El condiloma del cuello uterino II. Anatomía Patológica. Progr Obstet Ginecol. 1985; 28(9): 545-61. • Bonilla-Musoles F, Legua V, Ramírez JV, Remohí J, Blanes J, Ruiz A, Serra V, Simón C , Pellicer A. El condiloma del cuello uterino III. Diagnóstico y Tratamiento. Progr Obstet Ginecol. 1985; 28(10): 601-35.
Books Published (Editor)
• Simón C , Pellicer A, editors. Regulators of human implantation. Oxford (UK): Oxford University Press; 1995. • Remohí J, Simón C , Pellicer A, Bonilla-Musoles F, editors. Reproducción humana. Madrid (ESP): McGraw-Hill Interamericana; 1996. • Rodríguez L, Bonilla F, Pellicer A, Simón C , Remohí J, editors. Manual práctico de reproducaó humana. Rio de Janeiro (BRA): Livraria e Editora Revinter Ltda; 1998. • Pellicer A, Simón C , Bonilla-Musoles F, Remohí J, editors. Ovarian hyperstimulation syndrome. Pathophysiology, prevention and treatment. Rome (ITA): Serono Fertility Series; 1999. • Simón C , Pellicer A, Remohí J, editors. Emerging concepts on human implantation. Oxford (UK): Oxford University Press; 1999. • Remohí J, Romero J.L, Pellicer A, Simón C , Navarro J, editors. Manual práctico de esterilidad y reproducción humana. Madrid (ESP): McGraw-Hill Interamericana; 2000. • Simón C , Pellicer A, Doberska C, editors. Human implantation: recent advances and clinical aspects. Cambridge (UK): The Journal of Reproduction and Fertility Ltd; 2000. • Simón C , Pellicer A, editors. Procedings of de 2nd international workshop on human implantation recent advances and clinical aspects. Elsevier; 2001. • Remohí J, Pellicer A, Simón C , Navarro J, editors. Reproducción humana. 2 nd ed. Madrid (ESP): McGraw-Hill Interamericana; 2002. • Scheffer BB, Remohí J, García-Velasco JA, Pellicer A, Simón C , editors. Reprodução humana asistida. Sao Paulo (BRA): Atheneu; 2003. • Remohí J, Cobo A, Romero JL, Pellicer A, Simón C , editors. Manual práctico de esterilidad y reproducción humana. 2 nd ed. Madrid (ESP): Mc Graw-Hill. Interamericana; 2004. • Simón C , Pellicer A, editors. Stem cells in human reproduction, basic science and therapeutic potential. London (UK): Informa Healthcare; 2007. • Simón C , Horcajadas JA, García-Velasco JA, Pellicer A, editors. El endometrio humano. Desde
49 la investigación a la clínica. Buenos Aires (ARG); Madrid (ESP): Médica Panamericana; 2009. • Simón C , Pellicer A, editors. Stem cells in human reproduction, basic science and therapeutic potential. 2nd ed. London (UK): Informa Healthcare; 2009. • Simón C , Pellicer A, Reijo-Pera R, editors. Stem cells in reproductive medicine, basic science and therapeutic potential. 3nd ed. London (UK): Cambridge University Press; 2013. • Gardner DK, Simón C, editors. Handbook of In Vitro Fertilization. 4 th ed. (USA); CRC Press; 2017 • Simón C, Giudice L , editors. The Essential Uterine Handbook: Current Applications in Clinical Medicine. (USA) CRC Press; 2017. • Simón C, Rubio C, editors. Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine. (USA) CRC Press; 2017. • Flaws J, Jegou B, McCarrey J, Niederberger C, Simón C , Skinner M, Spenccer T, Swanson P, Yan W. Encyclopedia of Reproduction, 2nd EditionEncyclopedia. (USA) Elsevier; in process.
Monographs
Cuadernos de Medicina Reproductiva Editors: Pellicer A, Simón C . Editorial Médica Panamericana. Spain
1995 • Volumen 1 nº1. INSEMINACIÓN ARTIFICIAL. • Volumen 1 nº2. ENDOMETRIOSIS. 1996 • Volumen 2 nº1. EMBARAZO ECTÓPICO. • Volumen 2 nº2. HIPERANDROGENISMO. 1997 • Volumen 3 nº1. IMPLANTACION EMBRIONARIA. ASPECTOS BÁSICOS Y APLICACIONES CLÍNICAS. • Volumen 3 nº2. ABORTO RECURRENTE. 1998 • Volumen 4 nº1. OVARIO POLIQUÍSTICO. • Volumen 4 nº2. CLIMATERIO Y MENOPAUSIA. 1999 • Volumen 5 nº1. MIOMAS. • Volumen 5 nº2. ULTRASONIDOS Y REPRODUCCIÓN. 2000 Volumen 6 nº1. AMENORREAS. Volumen 6 nº2. REPRODUCCIÓN ASISTIDA DEL SIGLO XXI. 2001 Volumen 7 nº1. DIAGNÓSTICO PRENATAL. Volumen 7 nº2. CONTRACEPCIÓN EN EL SIGLO XXI. 2002 Volumen 8 nº1. CIRUGÍA ENDOSCÓPICA REPRODUCTIVA. Volumen 8 nº2. BIOLOGÍA MOLECULAR EN MEDICINA REPRODUCTIVA. 2003 Volumen 9 nº1. NEUROENDOCRINOLOGÍA REPRODUCTIVA. Volumen 9 nº2. ENDOCRINOLOGÍA DEL EMBARAZO. 2004 . Volumen 10 nº1. ESTUDIO DE LOS NIÑOS NACIDOS MEDIANTE TÉCNICAS DE REPRODUCCIÓN ASISTIDA. 2006 Coordinator Volumen 12 nº2. NUEVOS AVANCES EN MEDICINA REPRODUCTIVA. Editorial Adalia Farma.
Chapters Published in International Books 2017 • Miravet-Valenciano J, Balaguer N, Vilella F, Simón C. Molecular diagnosis of endometrial
50 receptivity. In: the Endometrial factor, a reproductive precision medicine approach, USA; CRC Press, 2017: 36-49. • Moreno I, Simón C. Microbiological diagnosis: the human endometrial microbiome – endometritis. In: the Endometrial Factor, A Reproductive precision medicine approach, USA; CRC Press, 2017: 65-77. • Balaguer N, Domínguez F, Simón C, Vilella F. Embryo/fetal-maternal cross talk. In: the Endometrial Factor, A Reproductive precision medicine approach, USA; CRC Press, 2017:243- 255. • Lalitkumar S, Gomez E, Ruiz-Alonso M, Valbuena D, Vilella F, Simon C . Endometrial receptivity. In: Handbook of in Vitro Fertilization 4 th Edition, USA; CRC Press, 2017: 317-330. • Rincon A, Ruiz-Alonso M, Diaz-Gimeno P, Vilella F, Simón C . Endometrial development and gene expression. In: Early pregnancy. 2 nd Edition, UK; Cambridge University Press, 2017: 1-12. • Miravet-Valenciano J, Marin C, Ruiz-Alonso M, Simón C . How to assiss the receptivity of the human endometrium? In: Infertility Management Series. Investigating Infertility. Jaypee Brothers Medical Publishers, 2017: 98-121. 2016 • Cervelló I, Medrano JV, Simón C . Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infertility. In: Translating Regenerative Medicine to the Clinic. Academic Press, 2016: 139-51. 2015 • Mir P, Al-Asmar N, Rodrigo L, Simón C , Rubio C. Debate: Should preimplantation genetic screening be performed in recurrent pregnancy loss? In: Recurrent pregnancy Loss. Causes, controversies and treatment. 2nd Edition, UK; CRC press, 2015: 55-8. 2014 • Medrano, JV, Simón C , Reijo- Pera R. Human germ cell differentiation from pluripotent embryonic stem cells and induced pluripotent stem cells. In: Human Fertility: Methods and Protocols (Methods in Molecular Biology 1154), USA: Springer; 2014: 563-78. 2013 ••• Mondión M, Garrido-Gómez T, Ruiz M, Simón C . Las ómicas en la preparación hormonal endometrial para la transferencia embrionaria. In: Donación de embriones, Spain: Momento Medico s.r.l; 2013: 237-50. ••• Medrano JV, Martínez-Arroyo A, Simón C , Reijo Pera RA. Germ-cell differentiation from pluripotent cells. In: Stem Cell in Reproductive Medicine, Basic Science adn Therapeutic Potential. 3rd Edition, UK; Cambridge University Press, 2013: 15-29. • Simón C , Reijo Pera RA. Gene expression dynamics during human embryonic development. In: Stem Cell in Reproductive Medicine, Basic Science adn Therapeutic Potential. 3rd Edition, UK; Cambridge University Press, 2013: 76-83. • Gargett CE, Cervelló I, Nguyen PT, Simón C . Adult stem cells in the human endometrium. In: Stem Cell in Reproductive Medicine, Basic Science adn Therapeutic Potential. 3rd Edition, UK; Cambridge University Press, 2013: 115-32. 2012 • Garrido-Gómez T, Domínguez F, Ruiz-Alonso M, Simón C . The Analysis of Endometrial receptivity. In: Textbook of Assisted Reproductive Techniques. UK; Informa Healthcare; 2012: 366-79. 2011 • Horcajadas JA, Martínez-Conejero JA, Simón C . Endometrial Receptivity in Natural and Controlled Ovarian Stimulated Cycles. In: Biennial review of infertility. Vol 2. USA; Springer; 2011: 43-57. • Novella-Maestre E, Simón C , García-Velasco JA, Pellicer A. Antiangiogenic agents for endometriosis. In: Human Assisted Reproductive Technology Future Trends in Laboratory and Clinical Practice. UK: Cambridge University Press • Domínguez F, Garrido T, Simón C . Proteomics analysis of the endometrium and embryo. Can we improve IVF outcome?. In: Human Assisted Reproductive Technology Future Trends in Laboratory and Clinical Practice. UK: Cambridge University Press 2010 • Garrido-Gómez T, Domínguez F, Simón C . Proteomics of embryonic implantation. In: Handbook of experimental pharmacology. Germany: Springer; 2010: 67-78
51 • Medrano JV, Marqués-Marí AI, Simón C . Germline differentiation from stem cells. In: Stem Cells: From Bench to Bedside, 2nd Edition. USA: World Scientific Publishing Co. Pte. Ltd; 2010: 557- 582. 2009 ••• Domínguez F, Horcajadas JA , Simón C . Embryonic and maternal dialogue and the analysis of uterine receptivity. In: Textbook of Assisted Reproductive Technologies, Laboratory and Clinical Perspectives. 3rd Edition. UK: Informa Healthcare; 2009: 427-34. • Marqués-Marí AI, Medrano JV, Simón C . Differentiating gametes from stem cells. In: Trends in Stem Cell Biology and Technology. USA; Humana Press; 2009: 137-47. ••• Mercader A, Valbuena D, Simón C. Human Embryo Culture. In: Essential Stem Cells Methods. USA; Academic Press, Elsevier; 2009: 341-57. • Galán A , Simón C. Monitoring stemness in long-term hESC cultures by real-time PCR. In: Human embryonic stem cells. USA; Humana Press Inc; 2009: 135-50. • Cervero A , Simón C . Involvement of leptin in the endometrial function. In: Leptin and leptin antagonists. USA; Landes Bioscience; 2009: 108-15. ••• Pellicer A , Garrido N, Budak E, Domingo S, Marqués-Marí AI, Simón C . Gamete generation from stem cells: will it ever be applicable? A clinical view. In: Stem cells in human reproduction, Basic science and therapeutic potencial. UK; Informa healthcare; 2009: 1-13. • Gargett CE, Cervelló I, Hubbard S , Simón C. Adult stem cells in the human endometrium. In: Stem cells in human reproduction, Basic science and therapeutic potencial. UK; Informa healthcare; 2009: 160-76. 2008 • García-Velasco JA, Cerillo M, Simón C . Dysfunctional uterine bleeding. In: Non-invasive management of gynaecologic disorders. UK; Informa healthcare; 2008: 63-8. • Domínguez F, Simón C , García-Velasco JA. Molecular mechanisms of implantation. In: Infertility and Assisted Reproduction. UK; Cambridge University Press, 2008: 46-52. • Busso CE, García-Velasco JA, Gómez R, Alvarez C, Simón C , Pellicer A. Ovarian hyperstimulation sindrome. In: Infertility and Assisted Reproduction. UK; Cambridge University Press, 2008: 243-57 . • Poo ME, Simón C. Stem cell research. In: Infertility and Assisted Reproduction. UK; Cambridge University Press, 2008: 695-705 • Domínguez F, Simón C. Embryo-endometrial signalling. In: The endometrium. Molecular, Cellular and Clinical Perspectives. UK; Informa Healthcare, 2008: 296-304. 2007 • Romeu M, Simón C , Pellicer A. Adult stem cells in the human ovary: hope or fiction? In: Stem cells in human reproduction, basic science and therapeutic potential. UK; Informa healthcare, 2007: 45-52. • Galán A, Pellicer A, Simón C . Human embryonic stem cell culture in feeder-free, xeno-free conditions. In: Stem cells in human reproduction, basic science and therapeutic potential. UK; Informa healthcare, 2007: 169-81. ••• Cervelló I, Simón C . Adult stem cells in the uterus. In: Advances in fertility studies and reproductive medicine. South Africa; Besins healthcare, 2007: 161-6 2006 • Galán A, Escobedo C, Valbuena D, Berna A, Simón C . From animal free to feeder free conditions. The desired derivation process for human embryonic stem cells. In: Embryonic stem cell research. USA; Nova science, 2006: 123-41. • Garrido N, Meseguer M, Remohí J, Pellicer A, Simón C. Anormalidades implantatorias en endometriosis. In: Endometriosis, fundamentos etiopatogénicos, diagnóstico y tratamiento. Argentina; Corpus, 2006: 227-43. • Gómez R, Zimmermann R, García-Velasco JA, Remohí J, Simón C , Pellicer A. Potential new treatment implications derived from recent molecular developments in ovarian hyperstimulation syndrome. In: Ovarian Hyperstimulation Syndrome. USA; Informa healthcare, 2006: 131-49. 2005 • Domínguez F, Horcajadas JA, Cervero A, Pellicer A, Simón C . Embryo interactions in human implantation. In: Implantation and early pregnancy. UK; Royal College of Obstetricians and Gynaecologist Press, 2005: 79-89.
52 • Horcajadas JA, Simón C . Is endometrial receptivity altered in COH cycles? In: Controversies in Obstetrics, Gynecology and Infertility. Israel; Oren Publisher Ltd, 2005: 84-90. • Bosch E, Mercader A, Simón C . Blastocyst versus cleavage stage embryo transfer: is one approach better than another? In: Contemporary Perspectives on Assisted Reproductive Technology. India; Elsevier, 2005: 144-52. 2004 • Horcajadas JA, Domínguez F, Martín J, Pellicer A, Simón C . Implantation and uterine receptivity. In: Advances in Fertility and Reproductive Medicine. The Netherlands; Elsevier B.V, 2004: 177- 82. • Domínguez F, Pellicer A, Simón C . Embryonic regulation in the implantation process. In: Textbook of Assisted Reproductive Technologies, Laboratory and Clinical Perspectives 2nd Edition. UK; Taylor & Francis, 2004: 413-23. ••• García-Velasco JA, Simón C . Control neuroendocrino de la reproducción. In: Ginecología y Obstetricia. Paraguay; Sivero, 2004: 27-34. 2003 • Valbuena D, Simón C . Implantação Embrionaria. In: Reprodução Humana Assistida. Brazil; Atheneu, 2003: 211-28. • Simón C . Clonagem. In: Reprodução Humana Assistida. In: Reprodução Humana Assistida. Brazil; Atheneu, 2003: 537-39. 2002 • Simón C , Caballero-Campo P, Galán A, Martín J, Meseguer M, Herrer R, Valbuena D, Jasper M, Mercader A. The endometrial epithelium. In: The endometrium. UK; Taylor & Francis, 2002: 194- 207. • Aplin J, Lacey H, Chen Ch, Jones C, Kimber S, Blissett M, Simón C . Model systems for the investigation of implantation. In: Cell-cell interactions 2ª Edición. UK; Oxford University Press, 2002: 229-58. • Krüssel J-S, Polan M.L, Simón C . Cytokine and growth factor network in human endometrium. In: Infertility and Reproductive Medicine Clinics of North America. USA; W.B Saunders Company, 2002: 97-112. • Simón C , Domínguez F., Pellicer A. Embryonic Regulation of Endometrial Receptivity in Humans. In: Advances in infertility treatment. Italy; Monduzzi Editore, 2002: 381-96. 2001 • García-Velasco JA, Gaitán P, Navarro J, Remohí J, Simón C , Pellicer A. In vitro fertilization. In: Polycystic ovary syndrome. UK; Martin Dunitz, 2001: 169-85. • Simón C , Rubio C, Rodrigo L. Preimplantation genetic diagnosis in assisted reproductive technologies. In: Diagnostic procedure and latest development in gynecologic and obstetric investigation. Italy; CIC Ed. Internazionali, 2001: 1. • De Pablo J.L, Meseguer M, Caballero-Campo P, Pellicer A, Simón C . Embryonic regulation in the process of implantation. In: Textbook of Assisted Reproductive Techniques. Laboratory and clinical perspectives. UK; Martin Dunitz, 2001: 341-5. • Domínguez F, Martín J, Navarro J, Pellicer A, Simón C . Embryo-endometrial interactions. Lessons from art. In: Infertility and Reproductive Medicine Clinics of North America. USA; W.B Saunders Company, 2001: 373-88. • Simón C , De Pablo J.L, Martin J, Meseguer M, Galán A, Pellicer A. Embryo-Maternal dialogue in the apposition and adhesion phases of human implantation. In: ART and the Human Blastocyst. USA; Springer, 2001: 199-209. • Pellicer A, Ruiz A, Valbuena D, García-Velasco J.A, Remohí J, Simón C . The effects of GnRH agonists (GnRHa) in the luteal phase of assisted reproduction cycles. In: Ovulation Induction. Italy; CIC Edizioni Internazionali, 2001: 65-75. • Pellicer A, Albert C, Garrido N, Ruiz A, Navarro J, Remohí J, Simón C . The role of the endothelium in the pathogenesis of ovarian hyperstimulation syndrome (OHSS). In: Ovulation Induction. Italy; CIC Edizioni Internazionali, 2001: 327-34. 2000 • Neuspiller F, Ardiles G, Zalategui J, Requena A, Simón C , Pellicer A, Remohí J. Induçao da ovulaçao com gonadotrofinas recombinantes. In: Induçao da ovulaçao. Brazil; Atheneu, 2000: 153-9.
53 • Neuspiller F, Ardiles G, Zalategui J, Requena A, Simón C , Pellicer A, Remohí J. Induçao da ovulaçao na inseminaçao artificial. In: Induçao da ovulaçao. Brazil; Atheneu, 2000: 137-48. • Moreno C, Simón C , Pellicer A, Remohí J. Análogos agonistas do Gnrh utilidades em reproduçao assistida. In: Induçao da ovulaçao. Brazil; Atheneu, 2000: 121-9. • Simón C , Martín J.C, Pellicer A. Oocyte quality versus endometrium quality in in vitro fertilization. In: Female reproductive aging. UK; Parthenon Publishing Group, 2000: 261-9. • Pellicer A, Rubio C, Ruiz A, Navarro J, RemohÌ J, Simón C . Preimplantation assessment of human embryos from women of advanced age and patients with recurrent miscarriage. In: Female reproductive aging. UK; Parthenon Publishing Group, 2000: 271-83. • Simón C , Valbuena D, Martín J.C, Pellicer A. Basic aspects of implantation and its disorders. In: Endocrine basis of reproductive function. Italy; Monduzzi Editore, 2000: 385-94. 1999 • Bernal A, Remohí J, Rubio C, Simón C . Fisiología de la concepción e implantación. In: Endocrinología reproductiva e infertilidad. Colombia; Catorse, 1999: 153-78. • Simón C , Moreno C, Pellicer A. The implantation process: lessons from ART. In: Female infertility therapy. Current practice. UK; Martin Dunitz, 1999: 394-406. • Remohí J, Guanes P, Amorocho B, Simón C , Pellicer A. Envejecimiento de la mujer y la capacidad de reproducción. In: Ginecología y obstetricia. Peru; José Pacheco Romero y MAD Corp S.A., 1999: 358-64. • Cobo A, Requena A, Neuspiller F, Aragonés M, Simón C , Remohí J, Pellicer A. In vitro maturation of human oocytes in unstimulated cycles: selection of the optimal day for ovum pick-up based on follicular size. In: Ovarian hyperstimulation syndrome. Pathophysiology, prevention and treatment. Italy; Serono Fertility Series, 1999: 157-66. • Albert C, Garrido N, Mercader A, Remohí J, Simón C , Pellicer A. The endothelium as the origin of OHSS. In: Ovarian hyperstimulation syndrome. Pathophysiology, prevention and treatment. Italy; Serono Fertility Series, 1999: 89-103. 1998 • Levy M, Mota K, Yalil S, García-Velasco J, Landeras J, Neuzpiller F, Simón C , Pellicer A, Remohí J. Critérios atuais no estudo da esterilidade. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 1-6. • Rodriguez M, Rodrigues de Sousa L, Remohí J, Simón C . Endometriose. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 13-21. • Ardiles G, Gartner B, Mota K, Marinaro A, Moreno C, Gaitán P, Pellicer A, Simón C , Remohí J. Protocolos de indução da ovulação. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 23-33. • Gartner B, Gallardo E, Marinaro A, Ardiles G, Mota K, García-Velasco J, Simón C , Pellicer A, Remohí J. Gonadotrofinas na indução da ovulação. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 35-42. • Ballesteros A, Simón C , Pellicer A, Rodrigues de Sousa L, Molero M.D, Remohí J. Profilaxia e tratamento da síndrome de hiperestimulação ovariana severa em fertilização assistida. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 43-51. • Gartner B, Simón C , Pellicer A, Rodrigues de Sousa L, Remohí J. Mulheres com baixa resposta à estimulação ovárica- Atitudes clínicas. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 53-6. • Guamán W, Neuspiller F, Mota K, Levy M, Yalil S, Landeras J, García-Velasco J, Simón C , Pellicer A, Remohí J. Técnicas de reprodução asistida. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 135-43. • Gallardo E, Romero J, Mínguez Y, Molero M.D, Gil-Salom M, Simón C , Pellicer A, Rodrigues de Sousa L, Remohí J. Reprodução assistida na infertilidade masculina. In: Manual prático de reprodução humana. Brazil; Revinter, 1998: 145-54. • Guanes P. P, Yalil S, Neuspiller F, García-Velasco J.A, Simón C , Pellicer A, Bonilla-Musoles F, Remohí J. Endoscopia diagnóstica en esterilidad. In: Esterilidad. Argentina; Lara producciones editoriales, 1998: 101-7. ••• Simón C , Portolés E, Mercader A, Francés A, Remohí J. Implantación embrionaria. In: Temas de reprodução assistida. Brazil; Revinter, 1998: 10-6. 1997
54 • Simón C , Mercader A. Citocinas e infertilidade. In: Fertilidade e infertilidade humana. Brazil; Medsi Ed, 1997: 115-29. • Simón C , Sánchez-Cuenca J, Herrer R, Pellicer A. Molecular mechanisms of implantation. In: In Vitro fertilization and assisted reproduction. Italy; Monduzzi Editore, 1997: 737-41. • Simón C , Valbuena D, Pellicer A. Recent research on the interleukin-1 system in embryonic implantation. In: New horizons in reproductive medicine. USA; The parthenon publising group, 1997: 321-7. • Remohí J, Gallardo E, Romero J, Rubio M.C, Gil-Salom M, Simón C , Pellicer A. La esterilidad masculina en medicina reproductiva. In: Reproduçao humana II. Brazil; Febrasgo, 1997: 105-22. • Simón C , Sanchez-Cuenca J, Herrer R, Pellicer A. Adhesión molecules in implantation. In: Infertility and assisted reproductive technology. Italy; Monduzzi editore, 1997: 151-4. 1995 • Pellicer A, Oliveira N, Gutiérrez A, Cano F, Ruiz A, Remohí J, Simón C . Implantation in endometriosis: lessons learned from IVF and oocyte donation. In: Progress in the management of endometriosis. USA; The Parthenon Publishing Group, 1995: 177-83. • Simón C , Francés A, Pellicer A, Polan M.L. Role of Interleukin-1 (IL-1) system in human implantation: Evidence for alteration of the IL-1 system in endometriosis. In: Progress in the management of endometriosis. USA; The Parthenon Publishing Group, 1995: 233-41. • Bonilla-Musoles F, Simón C , Raga F, Pellicer A, Bailao L. Transvaginal ultrasonic detection of markers of embryonic malformations. In: Geburtshilfe-Geburtsmedizin. Germany; Springer, 1995: 101-15. ••• Pellicer A, Simón C , Remohí J. Effects of aging on the female reproductive system. In: Recent developments in gynecology and obstetrics. USA; The Partenon Publishing Group, 1995: 107-11. 1992 ••• Pellicer A, Miró F, Sampaio M, Simón C , Gómez E, Remohí J. Effects of GnRH analogues on human granulosa and luteal cells. In: The basic science of GnRH analogues. USA, The Parthenon Publishing Group, 1992: 77-84. 1991 • Bonilla-Musoles F, Bailao LA, Simón C , Raga F, Pina-Neto JM. Malformações embrionarias. In: Ultra-sonografía transvaginal. Brazil; Diagnosis, 1991: 125-30. • Bonilla-Musoles F, Bailao LA, Simón C . Endometriose. In: Ultra-sonografía transvaginal. Brazil; Diagnosis, 1991: 203-7. • Bonilla-Musoles F, Bailao LA, Pellicer A, Simón C , Raga F, Pérez-Gil M. Endosonografia e fertilidade. In: Ultra-sonografía transvaginal. Brazil; Diagnosis, 1991: 27-49. 1990 • Pellicer A, Simón C . Desarrollo folicular, ovulación y fase lútea. In: Infertilidad. Paraguay; FLASEF, 1990: 2-27.
Chapters Published in National Books 2017
2015 • Miravet-Valenciano JA, Ruiz-Alonso M, Domínguez F, Vilella F, Simón C . Estudio de la receptividad endometrial. In: 5º Manual Práctico de Esterilidad y Reproducción Humana- Aspectos clínicos. 2015 in process • Garrido N, Martín J, Alamá P, Ruiz A, Bosch E, Pérez-Aytes A, Simón C . Test preconcepcional de compatibilidad genética y su uso en reproducción asistida. In: 5º Manual Práctico de Esterilidad y Reproducción Humana- Aspectos clínicos. 2015 in process 2014 • Milán M, Mateu E, Campos I, Rodrigo L, Peinado V, Gracía S, Mir P, Al-Asmar N, Rubio C, Simón C . Marcadores cromosómicos embrionarios. Aplicaciones clínicas. In: Cuadernos de Medicina Reproductiva, Biomarcadores, Spain; ANARR. Nuevo Siglo SL, 2014; 20(1): 25-34. • Sánchez I, Simón C , Domínguez F. Biomarcadores. In: Cuadernos de Medicina Reproductiva, Biomarcadores, Spain; ANARR. Nuevo Siglo SL, 2014; 20(1): 43-54. • Díaz-Gimeno P, Ruiz M, Blesa D, Simón C . Diagnóstico Invasivo de receptividad endometrial mediante marcadores moleculares. In: Cuadernos de Medicina Reproductiva, Biomarcadores,
55 Spain; ANARR. Nuevo Siglo SL, 2014; 20(1): 67-80. • Ramírez LB, Vilella F, Simón C . Diagnóstico no invasivo de receptividad endometrial mediante marcadores secretómicos. In: Cuadernos de Medicina Reproductiva, Biomarcadores, Spain; ANARR. Nuevo Siglo SL, 2014; 20(1): 81-92. 2013 • Mondión M, Garrido-Gómez T, Ruiz M, Simón C . Las ómicas en la preparación hormonal endometrial para la transferencia embrionaria. In: Donación de Embriones, Spain; Momento Medico s.r.l., 2013: 237 – 250. 2012 • Muñoz M, Fortuño S, Galindo N, Simón C , Pellicer A, Remohí J. Apiración Ovocitaria. In: Manual Práctico de Esterilidad y Reproducción Humana. Aspectos Clínicos, Spain; Médica panamericana, 2012: 413-21. • Simón C , Gómez-Garrido T. Establecimiento de la gestación, gametogénesis, fecundación, desarrollo embrionario e implantación. In: Tratado de Ginecología y Obstetricia. Ginecología y Medicina de la Reproducción, Spain; Médica panamericana, 2012: 971-77. 2009 • Simón C. Células madre, presente y future. In: La medicina del future, Spain; IVADIS, 2009: 217- 226. • Simón C. El endometrio humano. In: El endometrio humano, desde la investigación a la clínica, Spain; Médica panamericana, 2009: 2-9. • Valbuena D, Simón C. Regulación hormonal del endometrio humano. In: El endometrio humano, desde la investigación a la clínica, Spain; Médica panamericana, 2009: 12-17. • Domínguez F, Loro F, Simón C . Funcionalidad del endometrio. In: El endometrio humano, desde la investigación a la clínica, Spain; Médica panamericana, 2009: 20-37. • Cervello I, Simón C . Células madre adultas en el endometrio. In: El endometrio humano, desde la investigación a la clínica, Spain; Médica panamericana, 2009: 184-89. 2008 • Simón C , Escudero E. Establecimiento de la gestación: gametogénesis, fecundación y desarrollo del huevo hasta la formación de las tres hojas germinales. Implantación. In: Tratado de Ginecología Obstetricia y Medicina de la Reproducción 2ª Edición, Spain; Médica Panamericana, 2008: 196-205. • Oriol B, Bellver J, Requena A, García-Velasco JA, Simón C , Pellicer A, Remohí J. Tratamiento reproductivo en el aborto de repetición. In: Manual Práctico de Esterilidad y Reproducción Humana. 3ª Edición. Aspectos Clínicos, Spain; Mc Graw Hill / Interamericana, 2008: 157-170. • Labarta E, Bosch E, Bellver J, Melo M, Simón C . Luteinización prematura. Origen e implicaciones. In: Manual Práctico de Esterilidad y Reproducción Humana. 3ª Edición. Aspectos Clínicos, Spain; Mc Graw Hill / Interamericana, 2008: 210-7. • Muñoz M, Simón C , Domingo J, Lizán C, Pellicer A, Remohí J. Aspiración de ovocitos. In: Manual Práctico de Esterilidad y Reproducción Humana. 3ª Edición. Aspectos Clínicos, Spain; Mc Graw Hill / Interamericana, 2008: 281-8. • Crespo J, Vergara V, Goyri E, Coelho G, Simón C , Remohí J, Pellicer A. Transferencia embrionaria. In: Manual Práctico de Esterilidad y Reproducción Humana. 3ª Edición. Aspectos Clínicos, Spain; Mc Graw Hill / Interamericana, 2008: 289-96. 2007 • Domínguez F, Simón C . La Implantación. In: Obstetricia y Medicina Materno-Fetal, Spain; Médica Panamericana, 2007: 161-165. • Galán A, Simón C. Modelo de investigación básica con células madre embrionarias. In: Investigación biomédica en España: aspectos bioéticos, jurídicos y científicos, Spain; COMARES, 2007: 113- 150. • Marqués-Marí AI, Simón C. Diferenciación de ovocitos a partir de células madre. In: Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2007; 13(3): 83-90 • Bonilla-Musoles F, Raga F, Bonilla F Jr, Simón C, De los Santos MJ. Fecundación y anidación. In: Obstetricia, Reproducción y Ginecología Básicas, Spain; Médica Panamericana, 2007: 701-34 • Labarta E, Bosch E, Simón C , Pellicer A, Remohí J. Anovulación (I). In: Obstetricia, Reproducción y Ginecología Básicas, Spain; Médica Panamericana, 2007: 789-99. • Bosch E, Labarta E, Simón C , Pellicer A, Remohí J. Anovulación (II). In: Obstetricia,
56 Reproducción y Ginecología Básicas, Spain; Médica Panamericana, 2007: 801-8 2006 • Romeu M, Cervelló I, Sanchéz M, Pellicer A, Simón C. Células madre adultas en ovario. Una hipótesis atractiva. In: Nuevos avances en medicina reproductiva. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2006; 12(2): 53 • Cervelló I, Pellicer A, Simón C . Células madre adultas en el útero. In: Nuevos avances en medicina reproductiva. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2006; 12(2): 73-8. • Berna A, Galán A, Valbuena D, Sánchez-Luengo S, Melguizo D, Simón C Células madre. Posibilidades terapéuticas In: Nuevos avances en medicina reproductiva. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2006; 12(2): 79-90. • Bosch E, Reis S, Troncoso C, Epifanio R, Serra V, Simón C , Remohí J, Pellicer A. Donación de ovocitos en pacientes añosas. In: Nuevos avances en medicina reproductiva. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2006; 12(2): 91-102. 2005 • Garrido N, Meseguer M, Martínez-Conejero JA, Simón C , Pellicer A, Remohí J. Impacto de los criterios estrictos de morfología espermática en reproducción asistida. In: Andrología. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2005; 11(1): 9-14. • Galán A, Simón C . De la célula madre al ovocito/espermatozoide: ¿podemos crear gametos? In: Cáncer y reproducción. Cuadernos de Medicina Reproductiva, Spain; Adalia Farma, 2005; 11(2): 103-109. 2004 • Vidal C, Fernández M, Simón C , Gaytán J, Pellicer A, Remohí J. Planteamientos de reproducción en el síndrome de ovarios poliquísticos. In: Manual práctico de esterilidad y reproducción humana. 2ª edición, Spain; Mc Graw-Hill. Interamericana, 2004: 15-23. • Bosch E, Crespo J, Simón C , Pellicer A, Remohí J. Antagonistas de la GnRH. In: Manual práctico de esterilidad y reproducción humana. 2ª edición, Spain; Mc Graw-Hill. Interamericana, 2004: 97-106. • Crespo J, Bellver J, Bosch E, Ferro J, Pellicer A, Remohí J, Simón C , Vidal C. Transferencia embrionaria. In: Manual práctico de esterilidad y reproducción humana. 2ª edición, Spain; Mc Graw-Hill. Interamericana, 2004: 165-71. • Mercader A, Albert C, Galán A, Florensa M, de los Santos MJ, Simón C . Cultivo prolongado del embrión hasta blastocisto. In: Manual práctico de esterilidad y reproducción humana. 2ª edición, Spain; Mc Graw-Hill. Interamericana, 2004: 414-24. 2003 • Simón C , Escudero E. Establecimiento de la gestación: gametogénesis, fecundación y desarrollo del huevo hasta la formación de las tres hojas germinales. Implantación. In: Tratado de Ginecología Obstetricia y Medicina de la Reproducción, Spain; Médica Panamericana, 2003: 196-203. 2002 • Simón C , Escribá Mª J, Pellicer A. El punto de vista de la investigación en reproducción humana asistida. In: Etica y Clonación. Realidades y Exageraciones, Spain; Fundación Valenciana de Estudios Avanzados, 2002: 41-46. • Cervero A, Simón C . Proteómica. In: Biología molecular en medicina reproductiva. Cuadernos de medicina reproductive, Spain; Médica Panamericana, 2002; 68(2): 49-61. • Escribá MJ, Pellicer A, Remohí J, Simón C . Células madre: terapia de futuro. In: Biología molecular en medicina reproductiva. Cuadernos de medicina reproductive, Spain; Médica Panamericana, 2002; 6(2): 210-19. • Domínguez F, Simón C . Impronta genómica. In: Biología molecular en medicina reproductiva. Cuadernos de medicina reproductive, Spain; Médica Panamericana, 2002; 6(2): 107-18. • Domínguez F, Pellicer A, Simón C . Biología molecular de la implantación embrionaria. In: Biología molecular en medicina reproductiva. Cuadernos de medicina reproductive, Spain; Médica Panamericana, 2002; 6(2): 95-106. • Meseguer M, Garrido N, Pellicer A, Remohí J, Simón C . Biología molecular de la espermatogénesis. In: Biología molecular en medicina reproductiva. Cuadernos de medicina reproductive, Spain; Médica Panamericana, 2002; 6(2): 65-77.
57 • Valbuena D, Vidal D, Crespo J, Escudero E, Remohí J, Pellicer A, Simón C . Alta respuesta a las gonadotropinas e implantación. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 129-137. • Muñoz E, Muñoz M, Gaytán J, Rosal LP, Escudero E, Simón C , Pellicer A, Remohí J. Síndrome de Hiperestimulación Ovárica. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 139-51. • Muñoz M, Muñoz M, Campos I, López D, Simón C , Pellicer A, Remohí J. Reducción embrionaria tras técnicas de Reproducción asistida. In: Reproducción Humana 2ª Edición, Spain; McGraw- Hill. Interamericana, 2002: 153-9. • Gaytán J, Rosal JP, Escudero E, Camargo F, Molina N, Simón C , Pellicer A, Remohí J. Hidrosálpinx y Reproducción. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 237-43. • Requena A, Martínez-Salazar J, Párraga M, Isaza V, Landazábal A, Villasante A, García-Velasco JA, Simón C , Pellicer A, Remohí J. Inseminación Artificial. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 263-72. • Gil Salom M, Bellver J, Romero JL, Rossal LP, Gutiérrez A, Escudero E, Simón C , Pellicer A, Remohí J. Espermatogénesis: conceptos básicos. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 273-8 • Garrido N, Meseguer M, Simón C , Ferro J, Galán A, Mercader A, Pellicer A, Remohí J. El Citómetro de flujo: aplicaciones en el estudio de la reproducción humana. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 319-25. • Galán A, Simón C , Valbuena D, Troncoso C, Meseguer M, Crespo J, Pellicer A, Remohí J. Factores de supervivencia embrionaria y apoptosis. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 401-5 • Simón C , Valbuena D, Martín J, Mercader A, Garrido N, Rosal LP, Pellicer A, Remohí J. La Implantación embrionaria. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 421-29. • Mercader A, Simón C , Valbuena D, Escudero E, Bellver J, Crespo J, Pellicer A, Remohí J. Cocultivo. Cultivo de embriones humanos. In: Reproducción Humana 2ª Edición, Spain; McGraw- Hill. Interamericana, 2002: 469-73. • Rubio C, Rodrigo L, Vidal F, Mateu E, Bosch E, Simón C , Pellicer A, Remohí J. Diagnóstico preimplantatorio, de anomalías cromosómicas. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 513-19. • Ferro J, Rossal JP, Rodríguez M, Escudero E, Simón C , Pellicer A, Remohí J. Histeroembrioscopia. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 599-605. • Martín J, Escribá MJ, Simón C , Pellicer A, Remohí J. Técnicas de Reproducción asistida: investigación con células madre. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 619-21. • Martín J, Domínguez F, Simón C , Pellicer A, Remohí J. Nuevas tecnologías en medicina reproductora: Microarrays de DNA. In: Reproducción Humana 2ª Edición, Spain; McGraw-Hill. Interamericana, 2002: 623-7. 2001 • Simón C , Requena A. Agonistas y antagonistas en reproducción asistida. In: Ginecología. Temas actuales, Spain; Grapic-Lugo S.L., 2001: 99-114 2000 • Moreno C, Zuzuarregui J, Muñoz E, Landazábal A, Simón C , Pellicer A, Remohí J. Inseminación artificial. In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw-Hill. Interamericana, 2000: 81-95 • Requena A, Martínez Salazar J, Vidal C, Simón C , Pellicer A, Remohí J. La estimulación ovárica en reproducción asistida. In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw-Hill. Interamericana, 2000: 65-79. • Muñoz M, Neuspiller F, Alvarez J.C, Ibérico G, Landeras J, Ballesteros A, Simón C , Remohí J. Aspiración de ovocitos para fecundación in Vitro. In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw-Hill. Interamericana, 2000: 167-74 • Mercader A, Herrer R, Galán A, Albert A, Pellicer A, Remohí J, Simón C . Desarrollo del embrión
58 hasta el estadio de blastocisto. In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw-Hill. Interamericana, 2000: 287-302 • Rubio C, Vidal F, Mínguez Y, Giménez C, Romero J.L, Zulategui J, Simón C , Pellicer A, Egozcue J, Remohí J. Diagnóstico genético preimplantatorio: biopsia embrionaria e hibridación in situ fluorescente (FISH). In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw- Hill. Interamericana, 2000: 303-15 • Rubio C, Vidal F, Blanco J, Romero J.L, Pérez-Cano I, Simón C , Pellicer A, Egozcue J, Remohí J. Estudio de las anomalías cromosómicas de los espermatozoides mediante hibridación in situ fluorescente (FISH). In: Manual Práctico de Esterilidad y Reproducción Humana, Spain; McGraw- Hill. Interamericana, 2000: 317-22 • Mercader A, Mínguez Y, Herrer R, Remohí J, Pellicer A, Simón C . Cultivo embrionario prolongado: métodos, estrategias y resultados. In: Reproducción asistida del siglo XXI. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 2000; 6(2): 99-110. • Martín J.C, Valbuena D, Simón C , Ruiz A, Crespo J, Pellicer A. Nuevas tecnologías en el estudio de las ciencias de la reproducción: aplicaciones clínicas. In: Reproducción asistida del siglo XXI. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 2000; 6(2): 253-70. 1999 • Vergara F, Navarro J, Díaz I, Alvarez JC, Simón C , Remohí J, Pellicer A. Miomas y esterilidad/infertilidad. In: Miomas. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 1999; 5(1): 75-90 • Vanrell JA, Simón C . Gametogénesis, Espermiomigración, Fecundación e Implantación. In Esterilidad e Infertilidad, Spain; Masson, 1999: 37-50. 1998 • Simón C , Moreno C, Pellicer A. Técnicas para mejorar la implantación embrionaria. In: Inseminación artificial y fertilización in Vitro, Spain; Semfar S.L., 1998: 171-81. 1997 • Simón C , Herrer R. La implantación embrionaria. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 41-54. • Gaitán P, Valbuena D, Simón C . Moléculas de antiadhesión en el aborto de repetición. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 83-90. • Landeras J, Zuzuarregui JL, Simón C . Pérdida gestacional precoz. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 91-101. • Valbuena D, Gaitán P, García Velasco JA, Simón C . Implicación de los niveles de estradiol sobre la implantación embrionaria. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 103- 118. • García Velasco JA, Mercader A, Simón C . Fallo de implantación. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 119-131. • Mercader A, Albert C, Caballero Campo P, Simón C . Mejora clínica de la implantación embrionaria: cocultivo, el endometrio materno. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 133-43. • Simón C , Sánchez Cuenca J, Moreno C. Presente y futuro de la implantación embrionaria. ¿Qué podemos hacer para mejorarla?. In: Implantación embrionaria. Aspectos básicos y aplicaciones clínicas. Cuadernos de medicina reproductiva, Spain; Médica Panamericana, 1997; 3(1): 175-84. 1996 • Pellicer A, García-Velasco JA, Gallardo E, Remohí J, Simón C . El impacto de las técnicas de reproducción asistida en la incidencia del embarazo ectópico. In: Embarazo Ectópico. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 1996: 2(1): 19-30. • García-Velasco JA, Yalil S, Remohí J, Simón C , Pellicer A. La fecundación in Vitro en pacientes con ovarios poliquísticos. In: Hiperandrogenismos. Cuadernos de Medicina Reproductiva. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 1996: 2(2):165-83. • García-Velasco JA, Yalil S, Remohí J, Simón C , Pellicer A. Tratamiento del hiperandrogenismo
59 sin deseo reproductivo. In: Hiperandrogenismos. Cuadernos de Medicina Reproductiva, Spain; Médica Panamericana, 1996; 2(2):183-210. • Tsafriri A, Simón C . Ovulación. In: Reproducción humana, Spain; McGraw-Hill. Interamericana, 1996: 36-50. • Simón C , Portolés E, Mercader A, Francés A, Remohí J. Implantación embrionaria. In: Reproducción humana, Spain; McGraw-Hill. Interamericana, 1996: 70-6. • Francés A, Mercader A, Portolés E, Simón C . Citocinas: su implicación en la reproducción humana. In: Reproducción humana, Spain; McGraw-Hill. Interamericana, 1996: 88-100. 1992 • Bonilla-Musoles F, Raga F, Simón C , Pellicer A, Branco J, Remohí J. Reducción embrionaria transvaginal. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 389-96. • Remohí J, Bonilla-Musoles F, Simón C , Serra V, Sampaio M, Millet A, Matallín P, Fernandes H. Endometriosis. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson- Salvat, 1992: 367-82. • Bonilla-Musoles F, Vilela M, Simón C . Diagnóstico endosonográfico de la incontinencia urinaria. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 319- 329 • Bonilla-Musoles F, Sampaio M, Simón C , Serra V, Fernandes H, Pellicer A. Histerosalpingosonografía vaginal. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 307-10 • Bonilla-Musoles F, Sampaio M, Simón C , Raga F. Posibilidades de diagnóstico precoz en el cáncer de ovario. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson- Salvat, 1992: 269-278 • Bonilla-Musoles F, Machado L, Chagas K, Pérez-Gil M, Simón C . Endosonografía del carcinoma de cérvix. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 255-8 • Bonilla-Musoles F, Raga F Jr. García-Escobar M, Sampaio M, Fernandes H, Simón C . La incompetencia cervical: Valor de las distintas técnicas ecográficas. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 211-23 • Bonilla-Musoles F, Pardo G, Simón C, Sampaio M, Pellicer A. Alternativas actuales a la fertilización in Vitro y transferencia de embriones. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 193-210 • Bonilla-Musoles F, Pardo G, Sampaio M, Pérez-Gil M, Simón C , Jiménez LC, Serra V. Endosonografía vaginal en el embarazo ectópico. In: Tratado de Endosonografía en Obstetricia y Ginecología, Spain; Masson-Salvat, 1992: 83-95 • Bonilla-Musoles F, Simón C , Raga F, Blanes J. Endosonografía e Infertilidad. In: Avances en Reproducción Asistida, Spain; Diaz de Santos, 1992: 401-34 . 1988 • Bonilla-Musoles F, Machado L, Chagas K, Pérez-Gil M, Simón C . Endosonografía del carcinoma de cérvix. In : Sonografía transvaginal en Obstetricia y Ginecología, Spain; Salvat, 1988: 113-7.
60 Summary of Declaration of the academic teaching courses held as Lecturer or Professor Educational Accomplishment • Professor of Obstetrics and Gynecology, School of Medicine, University of Valencia. s (CME) Theory and Practice of Obstetrics and Gynecology to medical students at the 4th year of the Degree of Medicine at the school of Medicine since 1994 • Adjunct Clinical Professor. Department of Obstetrics and Gynecology. Stanford School of Medicine. Stanford University, Ca , USA. (2013-2019) • Adjunct Professor. Department of Obstetrics and Gynecology. Bayllor College of Medicine, TX, USA. (2013-2019) • Theoretical and practical training in Postgraduate and Master Courses since 1994.
Director of National Masters & Postgraduate Courses.
• Master on basic research techniques applied to Obstetrics and Gynecology. University of Valencia – IVI University Institute. Valencia, Spain. 1994 – Present. • Master in Human Reproduction, University of Valencia – IVI University Institute. Valencia, Spain. 1994 – Present. • Master in Biotechnology of assisted human reproduction. University of Valencia – IVI University Institute. Valencia, Spain. 2006 – Present. • Coordinator of the basic course for the use and analysis of microarrays. Fundación IVI, Instituto Universitario IVI, University of Valencia. Valencia, Spain. 2007 – 2009. • President of the teaching committee and Professor of the advanced course of biotechnology. Association of Biotechnology Companies of Valencia (BIOVAL). Valencia, Spain. 2008 – 2011.
Director of International Postgraduate Courses
• Treating with Cell-based Therapies What Cannot Be Treated with Drugs. Postgraduate course 73 rd Annual Meeting American Society for Reproductive Medicine (ASRM). San Antonio, Texas, USA. 2017 • Biomarkers in Reproductive Medicine. Postgraduate course 70 th Annual Meeting American Society for Reproductive Medicine (ASRM). Honolulu, Hawaii, USA. 2014 • Embryo Development: New Technologies and Science. Postgraduate course 68 th Annual Meeting American Society for Reproductive Medicine (ASRM). San Diego, California, USA. 2012 • Stem cells in reproductive medicine. Postgraduate Course 26 th Annual Meeting European Society of Human Reproduction & Embryology (ESHRE). Rome, Italy. 2010. • Alternatives for the production of pluripotent stem cells. Postgraduate Course 25 th Annual Meeting. European Society of Human Reproduction & Embryology (ESHRE). Amsterdam, The Netherlands. 2009 • Stem Cells in Reproductive Medicine. Postgraduate Course 64 th annual meeting American Society for Reproductive Medicine (ASRM). San Francisco, USA. 2008. • Stem Cells in Reproductive Medicine: The circle of life. Postgraduate course. 62 nd annual meeting American Society for Reproductive Medicine (ASRM). New Orleans, USA. 2006. • Innate immunity in the Reproductive Tract. Postgraduate course 61 st Annual Meeting American Society for Reproductive Medicine (ASRM) & 51 st Canadian Fertility and Andrology Society (CFAS). Montreal, Canada. 2005. • Controversies in Reproductive Loss. Postgraduate course 60 th annual meeting American Society for Reproductive Medicine (ASRM). Philadelphia, USA. 2004. • Assisted reproduction. Annual Meeting Postgraduate Course European Society for Gynecologic and Obstetric Investigation. Madonna di Campliglio, Italy. 2001 • New advances in the pathogenesis and management of endometriosis. Postgraduate
61 Course 17 th Annual Meeting European Society of Human Reproduction and Embryology (ESHRE). Lausanne, Switzerland. 2001. • Endometrial receptivity, molecular aspects and clinical implications. Postgraduate Course 56 th Annual Meeting American Society for Reproductive Medicine (ASRM). San Diego, California, USA. 2000
Professor in International Postgraduate Courses
• Eight technical innovations designed to improve reproductive outcome: promising or sobering facts? Pre-congress course 32 nd Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Helsinki, Finland. 2016. • Early Pregnancy and the role of stem cells. Pre-congress course 31 st Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Lisbon, Portugal. 2015. • Biomarkers in Reproductive Medicine. Postgraduate course 70 th Annual Meeting American Society for Reproductive Medicine (ASRM). Honolulu, Hawaii, USA. 2014. • ESHRE Campus. Making OHSS a complication of the past: State-of-the-art use of GnRH agonist triggering (ESHRE). Thessaloniki, Greece. 2014. • From Early Implantation to Later in Life. ESHRE Campus, Special Interest Group Early Pregnancy and the Task Force Basic Scientists in Reproductive Medicine (ESHRE). Brussels, Belgium. 2013. • How to Optimize IVF Results Based on High Quality Evidence. Middle East Fertility Society – Precongress Course, 29th Annual European Society of Human Reproduction and Embryology (ESHRE). London, UK. 2013. • Embryo Development: New Technologies and Science. Postgraduate course 68 th Annual Meeting American Society for Reproductive Medicine (ASRM). San Diego, California, USA. 2012. • The maternal embryonic interface. ESHRE Campus Workshop. Valencia, Spain. 2010. • ESHRE basic course on “Update on pluripotent stem cells (HESC and IPS). Valencia, Spain. 2010. • Stem cells in reproductive medicine, Pre-congress course 26 th Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Rome, Italy. 2010. • Endometriosis: How new technologies may help, Pre-congress course 26 th Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Rome, Italy. 2010. • New hESC derivation strategies maintaining embryo viability. Course and workshop on Pluripotent Stem Cells. European Society of Human Reproduction & Embryology (ESHRE). Barcelona, Spain. 2010. • System biology tools and preclinical models for translational research in endometriosis and adhesion formation: lessons from cancer and inflammation biology. European Society ofHuman Reproduction and Embryology (ESHRE). Leuven, Belgium. 2009. • Introduction to regenerative medicine: biology & application of human stem cells. Prince Felipe Research Center. Valencia, Spain. 2008. • Stem cells in reproductive medicine. Postgraduate course 64 th annual meeting American Society for Reproductive Medicine (ASRM). San Francisco, USA. 2008. • Gene regulation of endometrial receptivity. Postgraduate course on endometrial receptivity. 59 th annual meeting of the American Society for Reproductive Medicine (ASRM). San Antonio, Texas, USA. 2003. • Non-viable embryos as a source of hESc. Pre-Congress course organized by the special interest group on stem cells. European Society of Human Reproduction and Embryology (ESHRE). Madrid, Spain. 2003.
62 • Chromosomal abnormalities and embryonic development. Pre-Congress course organized by the special interest group in early pregnancy. 18 th annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Vienna, Austria. 2002. • 5th European Society of Human Reproduction and Embryology (ESHRE) course in reproductive endocrinology. Athens, Greece. 2001. • New advances in ovulation induction. Postgraduate course on assisted reproduction. 5th Congress of the European Society for Gynecologic and Obstetric Investigation (ESGOI). Madonna di Campliglio, Italy. 2001. • Postgraduate course: Endometrial receptivity, molecular aspects and clinical implications. 56th Annual Meeting of the American Society for Reproductive Medicine. San Diego, California, USA. 2000. • Postgraduate course, advances on reproductive medicine. Facultad de Medicina Pontificia, Universidad Javeriana. Santafé de Bogotá, Colombia. 2000. • Pre-Congress Course on endometriosis “pathology of endometriosis related infertility”. 16th annual meeting European Society of Human Reproduction and Embryology (ESHRE). Bologna, Italy. 2000. • Assisted reproductive techniques in the 21st Century, 55th annual meeting of the American Fertility Society for Reproductive Medicine (ASRM). Toronto, Canada. 1999. • Postgraduate course on reproductive medicine: Current concepts and new perspectives a review course. Venice, Italy. 1998. • Postgraduate course: human conception from oocyte to blastocyst and implantation. 54th Annual Meeting of the American Fertility Society for Reproductive Medicine (ASRM) & 16th World Congress on Fertility and Sterility. San Francisco, USA. 1998. • Postgraduate course: immunology in reproductive medicine 1998. 54th Annual Meeting of the American Society for ReproductiveMedicine (ASRM) & 16th World Congress on Fertility and Sterility. San Francisco, USA. 1998.
Professor in National Postgraduate Courses
• V Updating Course: medical diseases, pregnancy and assisted reproductive techniques. Instituto Valenciano de Infertilidad.Vigo, Spain. 2010. • Update in stem cells and cell therapy. Colegio Profesional de Técnicos Superiores Sanitarios de la Comunidad Valenciana & Prince Felipe Research Center. Valencia, Spain. 2009. • II course on assisted reproduction and oncology. Instituto Valenciano de Infertilidad. Seville, Spain. 2009. • Course title: Advanced Course on Biotechnology in the company. Asociación de Empresas Biotecnológicas de la Comunidad Valenciana (BIOVAL) Valencia Bioregion. Valencia, Spain. 2009. • The frontiers of biology, 200 years after the birth of Darwin. The challenges of science journalism. Menendez y Pelayo International University. Santander, Spain. 2009. • When the chemistry is biology and vice versa. University of Málaga. Ronda, Málaga, Spain. 2009. • Master in establishment and management of innovate and technology companies. New business models in biomedicine. Valencia, Spain. 2008. • Cell therapy: a new strategy for regenerative medicine. University of Málaga. Vélez Malaga, Spain. 2007. • Basic course on the use and analysis of microarrays. Fundación Instituto Valenciano de Infertilidad & IVI University Institute. Valencia, Spain. 2007. • Training course for senior technicians clinical diagnostic laboratory. Asociación de Técnicos Superiores Sanitarios de la Comunidad Valenciana & Miguel Hernández
63 University San Juan, Alicante, Spain. 2007. • Endocrine gynecology (including menopause), endometriosis and infertility. Spanish Gynecology and Obstetrics Society. Alicante, Spain. 2006. • Advances in research on neuromuscular diseases. University of the Basque Country. San Sebastian, The Basque Country, Spain. 2005. • Cell Therapy, regenerative medicine. Complutense University of Madrid, Genetrix and Lilly Foundation. San Lorenzo de El Escorial, Madrid, Spain. 2005. • Human reproduction and cancer. University Rey Juan Carlos. Aranjuez, Madrid, Spain. 2004. • Basic research techniques in reproductive medicine. Fundación Instituto Valenciano de Infertilidad. Valencia, Spain. 2004 – Present. • Cardiovascular disease. Perspective from molecular medicine. Complutense University of Madrid & National Cardiovascular Research Center. San Lorenzo de El Escorial, Madrid, Spain. 2003. • Human fertility, infertility, contraception and ethics. School of Medicine, University of Valencia. Valencia, Spain. 2002. • V Doctorate and III Neonatology course. Advances in perinatology. School of Medicine, University of Valencia. Valencia, Spain. 2002. • Course title: Basic course in human reproduction. Spanish Fertility Society. Madrid, Spain. 2001. • Family Planning. School of Medicine, University of Valencia. Valencia, Spain. 2000. • Training course on In Vitro fertilization from year 2000. Dexeus University Institute. Barcelona, Spain. 2000. • Physiology and endocrinology of reproduction. School of Medicine, University of Valencia. Valencia, Spain. 2000. • Assisted Reproduction. Ph D degree course. Barcelona Clinic Hospital. Barcelona, Spain. 1999. • Family planning. Ph D degree course. School of Medicine, University of Valencia. Valencia, Spain. 1999. • III Doctorate and I Neonatology course. Advances in perinatology. School of Medicine, University of Valencia. Valencia, Spain. 1998. • Sterility and infertility. Spanish Gynecology and Obstetrics Society. Marbella, Spain. 1997. • Artificial insemination and In Vitro fertilization course. Hospital 12 de Octubre. Madrid, Spain. 1997. • Reproductive endocrinology and endometriosis. Ph D degree course. School of Medicine, University of Alicante. Alicante, Spain. 1996. • VI international course on advances 95 in ginecology, obstetrics and human reproduction. Barcelona, Spain. 1995. • Current problems in human reproduction. University of the Basque Country. San Sebastián, The Basque Country, Spain. 1994. • Implantation. Spanish Fertility Society. Valencia, Spain. 1994.
Other Teaching
Postdoctoral Fellows:
Currently, I have 4 postdoctoral fellows that joined my laboratory after finishing their PhDs and have completed postdoctoral visits at various universities such as Stanford, UCSF, Harvard, Yale. To date, my fellows have succeeded in both academic and private venues with positions at Igenomix SL, University of Valencia, University of Seville, and Autónoma de Madrid.
64 Medical Fellows/Residents/Mentorships:
I have trained or am currently training many medical fellows in my laboratory primarily from Medicine, Genetics, Ob-Gyn and Urology (50 fellows total). I also host international medical fellows mainly from South America/Mexico,and Europe funding programme: Brazilian Research Council (CnPQ),Santiago Grisolia and Leonardo da Vinci “Mobil 2012”
Graduate Students:
Currently I am supervising 10 PhD students and I have been the supervisor of a total of 33 PhD students that graduated from my laboratory (section Undergraduate & Post-Graduate Teaching). These students are obtaining, or have already obtained, degrees in Genetics, Biology and Biochemistry and conducted their research in my laboratory.
Undergraduates:
Undergraduates are a source of energy and inspiration in my laboratory. We have a summer program (2 months) for graduate students from University of Valencia, and other national or international universities.
Medical Fellows/Residents/Mentorships:
I have trained or am currently training many medical fellows in my laboratory primarily from Medicine, Genetics, Ob-Gyn and Urology (50 fellows total). I also host international medical fellows mainly from South America/Mexico,and Europe funding programme: Brazilian Research Council (CnPQ),Santiago Grisolia and Leonardo da Vinci “Mobil 2012”
65 Invited Seminars 2017 / Symposium • Translational Reproductive Biology and Clinical Reproductive Endocrinology, Presentations Paradigm Changes you May not Hear About Elsewhere and Think Differently; New International York City NY, USA; November 2017. “How Important is the Implantation Window? Invitations Absolutely Important”, “Bone Marrow-Derived Stem Cells to Treat Asherman’s Syndrome” • 62nd Annual Meeting of Japan Society for Reproductive Medicine; Shimonoseki City, Yamaguchi, Japan; November 2017. “How the Mother Communicates and Modifies the Preimplantation Embryo – Implications and Onset of Adult Diseases” • 73rd Annual Meeting of the American Society for Reproductive Medicine, Precongress Course, Treating with Cell-based Therapies What Cannot Be Treated with Drugs; San Antonio TX, USA; October 2017. “Recent Developments in Tissue Engineering and Regenerative Medicine”, “Cell Therapy and Tissue Engineering from and Towards the Uterus” • 73rd Annual Meeting of the American Society for Reproductive Medicine, Precongress Course, Emerging Therapeutic Tools in the Assisted Reproductive Technology Laboratory; San Antonio TX, USA; October 2017. “Embryo/Endometrium Dialogue During Implantation: Why Sometimes Healthy Embryos Fail To Implant”, “Stem Cells and Artificial Gametes” • 73rd Annual Meeting of the American Society for Reproductive Medicine, Precongress Course, Actualidades en Reproducción Asistida: El Punto de Vista Clínico para el Biólogo y un Punto de Vista del Biólogo para el Clínico. Presentado en Español; San Antonio TX, USA; October 2017.” Fallas de Implantación en Transferencias de Embriones Euploides”, “Rol del ERA (Endometrial Receptivity Assay” en Técnicas de Reproducción Asistida?” • 73rd Annual Meeting of the American Society for Reproductive Medicine, Expert Encounters; San Antonio TX, USA; October 2017. “Embryonic and Uterine Checkpoint Needed for a Succesful Pregnancy” • 73rd Annual Meeting of the American Society for Reproductive Medicine, Round Table Regenerartive Medicine and Stem Cell Biology; San Antonio TX, USA; October 2017. “Stem Cell Therapy in Asherman’s Syndrome” • 50th Annual Meeting Society for the Study of Reproduction; Washington DC, USA; July 2017. “Met and unmet needs in human endometrial biology and medicine” • OvaTools ART Institute Grand Opening Symposium; Fort Lauderdale, Florida, USA; July 2017. “Endometrial receptivity assay and personalized embryo transfer” • 54th Congreso Mexicano de la Medicina de la Reproducción, Asociación Mexicana de Medicina de la Reproducción; Rivera Maya, Mexico;L July 2017. “Análisis genético preimplantacional. ¿Para todas?” Plenary Lecture • 32nd Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE); Geneva, Switzerland; July 2017. Human Reproduction keynote lecture . “Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman’s syndrome and endometrial atrophy: a pilot cohort study” ••• 32nd Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE); Precongress Course. Geneva, Switzerland; July 2017. “Stem cell therapy to improve implantation failure” ••• 2º Congresso Internacional Huntington de Reprodução Humana; São Paulo, Brazil; May 2017. “Implantation failure and endometrial dysfunction” • 3º Simpósio Internacional Nilo Frantz, Porto Alegre, Brazil; May 2017. “O futuro da medicina reprodutiva”, “Personalização do endométrio humano utilizando o "ERA" para o ajuste da janela de implantação” ••• 7th International IVI Congress; Bilbao, Spain; May 2017. “Wrong timing. The endometrial perspective” • 2nd International EXPERMED Congress, Expert Meeting in Personalized Reproductive Medicine; Kyrenia, Cyprus; April 2017. “Personalized Reproductive Treatment & Care: Where are we now and what does the future hold?“ Keynote lecture ••• 16th International Conference on Preimplantation Genetic Diagnosis, organized by the
66 Preimplantation Genetic Diagnosis International Society; Valencia, Spain; March 2017. “Diagnosis of Endometrial Receptivity from the Bench to the Patient using an evidence based medicine approach”, “What about the maternal endometrium. The search for the personalized WOI and Microbiota” • 63th Annual Scientific Meeting Society for Reproductive Investigation; Orlando, USA; March 2017. “Transcriptomic Assessment of Endometrial Receptivity: ERA Testing”
2016 • Hong Kong University - Queen Mary Hospital Assisted Reproduction Programme. 30th Anniversary Celebration Symposium; Hong Kong and Shenzhen, Hong Kong and China; December 2016. “Personalized reproductive medicine”, “Omics of endometrial receptivity” • Ovarian Club VII. Building a bridge between science and clinical practice; París, France; November 2016. ”The Symphony between the blastocyst and the endometrium” • IVI Middle East Fertility Clinic. Latest Advances in enhancing success rates in ART; Abu Dhabi, United Arab Emirates; November 2016. “Embryo mitocondrial status: a new tool for viability”, “ERA and personalized embryo transfer for endometrial receptivity assessment”, “Why euploid embryos may not implant” • XXX. Jahrestreffen der Deutschen IVF-Zentren; Dresden, Germany; November 2016. “Optimizing the lutheal support: synchrony between the endometrium and the embryo is what matters” • 1er Encuentro Binacional México-España de Reproducción Humana; México DF, México; November 2016. “Human endometrial receptivity. From basic research to a clinically validated diagnostic test”, “PGS, How, When and to Whom” • 4º training course in reproductive medicine reproduction reloaded, Humanitas Fertility Center; Milan, Italy; October 2016. “Personalized embryo transfer (pET) using endometrial receptivity analysis to adjust the window of implantation” • 19th anual conference of the Japan Society of Asisted Reproduction; Kobe City, Japan; October 2016. “Identifying the personalized window of implantation • 4th State Key Laboratory of Stem Cell and Reproductive Biology Symposium; Beijing, China; October 2016. “How the mother communicates with the preimplantation embryo and modifies its transcriptome. Implications in pregnancy and the potential impact on the onset of adult diseases” • 72 nd Congress of the American Society for Reproductive Medicine; Salt Lake City, Utah, USA; October 2016. “Optimizing endometrial receptivity”, “the advancement of cell theraphy in reproductive medicine: Asherman syndrome and atrophic endometrium” • XVII Congreso Argentino de Medicina Reproductiva SAMeR 2016; Tucumán, Argentina; Agosto-Septiembre 2016. “Interacción molecular en la implantación embrionaria”, “Screening genético preimplantatorio (PGS)”, “Futuro de las stem cells en medicina reproductiva”, “Biomarcadores de receptividad uterina: validez del ERA” • 20º Congresso Brasileiro de Reproduçao Assistida; Belo Horizonte, Brazil; September 2016. “Human embryonic implantation today. What are the clinical translation of the basic knowledge”, “Porque embriões euploides não implantam” • 49th Annual Meeting Society for the Study of Reproduction. Systems Biology of Reproduction. Workshop on Emerging Technologies in Reproductive Research in the ERA of Big Data; San Diego, CA, USA; July 2016. “Development of prediction models of the human endometrium in health and disease” • 29th Annual In vitro fertilization and embryo transfer. A comprehensive Update – 2016; San Diego, CA, USA; July 2016. “Personalized embryo transfer using the endometrial receptivity array to adjust the window of implantation”, “The future on reproductive
67 medicine – extensive genetic screening, stem cells, biomarkers and tissue engineering – a future full of promise”, • 29th Annual In vitro fertilization and embryo transfer. A comprehensive Update – 2016. MINI-SYMPOSIUM: ¿Qué hacer cuando todos las embriones son normales; San Diego, CA, USA; July 2016. “El papel del Estradiol elevado sobre el endometrio. Tiene sentido la estrategia freeze-all? La importancia de la receptividad endometrial. En definitiva: una estrategia global vs personalizada para preparar el endometrio adecuadamente” • 32nd Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE) Precongress Course; Helsinki, Finland; July 2016. “Gene profiling in endometrium: Does personalized embryo transfer correct for implantation failure?” • Merck Symposium at ESHRE 2016. Reducing time to birth through precisión, prediction & personalized medicine; Helsinki, Finland; July 2016. “New technologies in predictable and personalized to reduce time to birth” • 13th Congress of the International Society for Immunology of Reproduction (ISIR) and European Society for Reproductive Immunology (ESRI); Erfurt, Germany; June 2016. “The "personalized" embryo transfer paradigm” • 18 Journées Nationales de la Société de Médecine de la Reproduction (SMR); Bourdeaux, France; May 2016. “Cellules souches et traitement de la fertilité” • New England Fertility Society 2nd Quarterly Meeting; Newton, MA, USA; May 2106. “Human endometrial receptivity, clinical diagnostic test in use and in progress” • University of California San Francisco; San Francisco, CA, USA; May 2016. “How the mother communicates and modifies the preimplantation embryo - implications for implantation and onset of adult diseases” • 3rd Biomarker Meeting in Personalized Reproductive Medicine; Valencia, Spain; April 2016. “Diagnosis of endometrial receptivity using ERA. clinical application”, “Identifying and personalizing the window of implantation. ERA clinical results” • Einladung zur Eröffnung der tagesklinik mit mini-symposium; Küsnacht, Switzerland; April 2016. “Pre-implantation genetic screening: an invaluable tool for the difficult ART patient“ • 63rd Annual Scientific Meeting Society for Reproductive Investigation; Montreal, Canada; March 2016. “Stem cell therapy in Asherman síndrome and atrophic endometrium” • Queens University, Seminar Series; Kingston, Canada; March 2016. “Human somatic cells subjected to genetic reprogramming with 6 germ line-related factors display meiotic germ cell-like features”. • 35th Scientific Meeting Belgian Society for Reproductive Medicine (BSRM); Mechelen, Belgium; March 2016. “Is ERA really the holy grail?” • 17th World Congress of the International Society of Gynecology; Florence, Italy; March 2016. “Stem Cell Therapy of the Endometrium in Asherman´s syndrome and atrophic endometrium” • Upper Egypt assisted reproductive symposium, an international symposium in the land of the Pharaohs; Cairo, Egypt; February 2016.” What is The Best Day for Embryo Transfer? The Uterine View”, “Carrier Screening for Couples Wishing to Conceive - What is Possible, What is Reasonable?”, “The Dialogue Between The Maternal Endometrium and The Embryo - Potential Impact on The Onset of Adult Diseases”, “Stem Cell Therapy for Endometrial Regeneration”
2015 • European Fertility Meeting: Strategies to improve IVF success rate; Rome, Italy; December 2015. “Methods for improving endometrial receptivity” • 10th Biennial Meeting of the Pacific Society for Reproductive Medicine, 69th Annual
68 Meeting of the Korean Society for Reproductive Medicine and The International Ovarian Conference 2015; Seoul, Korea; November 2015. ”New Technologies May Improve Patient Success Rates: How to Integrate It into Practice?” • Northern California Association of Reproductive Biologists; San Francisco, CA, USA; Novembrer 2015. “Building the Future of Reproductive Medicine. Work in Progress” • Ovarian Club VI. It’s All About Energy: what More Can We Do to Improve Pregnancy Success Rates?; Barcelona, Spain; November 2015. “Mitochondrial DNA content as viability score in human euploid embryos: Less is better” • Ferring Microbiota Workshop; St-Prex, Switzerland; November 2015. “Reproductive Tract Microbiome during Fertility Treatment” • 71st American Society for Reproductive Medicine Annual Meeting. Interactive Session. Baltimore, MD, USA; October 2015. “Implantation Failure – Endometrial Receptivity Assessment vs. Preimplantation Genetic Screening” • 71st American Society for Reproductive Medicine Annual Meeting. Howard and Georgeanna Jones Symposium. Baltimore, MD, USA; October 2015. “Elective Freeze All: What is the Scientific Evidence” • Focus 2015 Advances in Reproductive Medicine; Ragusa Ibla, Italy; September 2015. “Which is the best day for embryo transfer? The uterine view” • Primer Simposio Nacional sobre Genética y Medicina Reproductiva, Asociación Guatemalteca de Fertilidad y Reproducción Humana; Ciudad de Guatemala, Guatemala; September 2015. “Células Madre Endometriales” • XXIII Nordic Fertility Society Meeting; Reykjavík, Iceland; August 2015. “Endometrial Receptivity and Biomarkers” • 28th Annual in Vitro Fertilization and Embryo Transfer; Santa Barbara, CA, USA; July 2015. “Uterine Receptivity and the Importance of Embryo-Endometrial Synchrony” “Stem Cells and Tissue Engineering in Reproductive Medicine – Can We Fashion New Eggs, Sperm adn Endometrium” • 31st Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Pre-congress course Early Pregnancy and the role of stem cells. Lisbon, Portugal. June 2015. “Asherman syndrome as a complication of curettage for miscarriage: endometrial stem cells as a solution? This is near future” • 31st Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). MSD Company Simposium. Lisbon, Portugal. June 2015. “New Technologies May Improve Patient Success Rates: How to Integrate into Practice” • 31st Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE). Illumina Company Simposium. Lisbon, Portugal. June 2015. “Personalized Medicine in Reproductive Medicine Applied to Embryos. Clinical Benefits of PGS” • NIH Reproductive Sciences Branch Directors’ meeting, Endometrium, Placentation and Implantation (EPI) Research Focus Group (RFG); Bethesda, Maryland, USA; May 2015. “Endometrium, Endometriosis, and Implantation/Placenta” • 14th International Conference on Preimplantation Genetic Diagnosis (PGD); Chicago, Illinois, USA; May 2015. “Future Clinical Strategies in PGD to further Improve its Effectiveness and Outcome” • MSD Clinical Observation Program for Fertility; Valencia, Spain; May 2015. “Diagnosis of Endometrial Receptivity” • Teva Women's Health EU Summit; Vienna, Austria; April 2015. “Endometriosis as a driver of infertility” • 6th International IVI Congress; Alicante, Spain; Arpil 2015. “Diagnosis and improvement of the endometrial factor: Facts and fallacies” • Visiting Professor CHA Fertility Center, CHA University; Seoul, Korea; April 2015. “Edometrial Receptivity Array”, “Preimplantation Genetic Screening” • 67th Annual Congress of Japan Society of Obstetrics and Gynecology; Yokohama, Japan; April 2015. “Human Endometrial Receptivity - From Basic Science to Diagnostic Applications”, “Uterine Fibroids” ••• Ministry of Health, Working Visit; The Role of Endometrial & Genetic Testing in Modern
69 Reproductive Medicine; Jahra Hospital, Jahra, Kuwati; April 2015. “Current & Future Role of Carrier Screening”. “Current & future Role of PGS and PGD”. “Current & Future Role of Non invasive Prenatal Genetic Testing”. “Current & Future Endometrial Receptivity Testing” • 62nd Annual Meeting, Society for Reproductive Investigation (SRI) Endometrial Satellite; San Francisco, USA; March 2015. “Human endometrial microbiota, reality or fiction?” • Stanford Reproductive and Stem Cell Biology Symposium for 2015; Stanford University, USA; March 2015. “Human somatic cells subjected to genetic reprogramming with 6 germ line-related factors display meiotic germ cell-like features” • 63rd Annual Meeting Pacific Coast of Reproductive Society; Rancho Mirage, California, USA; March 2015.”Invasive and non-invasive diagnosis of endometrial receptivity”, “Stem cells therapy for endometrial Regeneration” • GENERA and BIOROMA Symposium 2015. The new era of PGS application in ART; Rome, Italy; February 2015. “Endometrial receptivity evaluation” • AGRBM-DGRM meeting; Düsserldorf, Germany; January 2015. “Genetic matching of oocyte donor and recipient couple: what is possible, what is reasonable?” • Fertility 2015; Birmingham, UK; January 2015. “Human endometrial receptivity. Clinical application” 2014 • ESHRE Campus. Making OHSS a complication of the past: State-of-the-art use of GnRH agonist triggering; Thessaloniki, Greece; November 2014. “Invasive and non- invasive diagnosis of endometrial receptivity” • 26º Congresso Brasileiro de Reproduçao Humana; Porto Alegre, Brazil; November 2014. “Reconstrução endometrial a partir de células-tronco”, “Implantação embrionária: o que nos falta entender?”, “A importância das análises genéticas nos tratamentos de RA” • Divisão de Clínica Ginecológica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Sao Paulo, Brazil; November 2014. “Medicina personalizada em reprodução humana” • 15ème Journeé sur l’Assistance Médicale à la Procréation de l’Hôspital Américan de Paris; Paris, France; November 2014. “ERA (Endometrial Receptivity Array)”, “Endomètre hypotrophique et cellule souche” • Revolutionizing infertility treatments, showcasing the global advancements; Bangalore, India; September 2014. “What does epigenetics mean in IVF?”, “PGS: pros and cons in AMA, RM and RIF”, “Endometrial receptivity and genomics” • Latest updates in assisted reproductive technology. NOVA IVI Fertility; New Delhi, Hyderabad & Chennai, India; September 2014. “New horizons in PGS & endometrial receptivity” • 19e Journées de la Fédération Française d’Étude de la Reproduction; Paris, France; September 2014. “Cellules souches et implantation” • 8th IVF Preceptorship: current practice in the 21 st century; Madrid & Valencia, Spain; September 2014. “Scratch or not to scratch?” “ Case study on lecture: individualized embryo transfer: future or reality?” • Gordon Research Conference on Mammalian Reproduction. Translating Basic Science into Clinical Applications; New London, NH, USA; August 2014. “Infertility and contraception. Discussion leader” • Living innovation in ART: blending medicine, science and technologies to maximize success for the benefit of the patients. Merck Serono Sponsored Symposium ESHRE 2014; Munich, Germany; July 2014. “Breakthrough innovation in uterine receptivity diagnostics” • 27 th Annual In Vitro Fertilization and Embryo Transfer. A Comprehensive Update – 2014. David Geffen School of Medicine, University of California Los Angeles; Santa Barbara, California, USA; July 2014. “Stem Cells and tissue engineering in reproductive medicine – can we fashion new eggs, sperm and endometrium?”, “Uterine receptivity - arrays, scratching, and more?” • Advisory Board Meeting, Merck Sharp & Dohme (MSD); Saint-Petersburg, Russia;
70 June 2014. “Diagnosis of the endometrial receptivity status” • Academic Visit to ART Unit, Department of Obstetrics & Gynaecology, Chinese University of Hong Kong; Hong Kong; May 2014. “Stem cell theraphy at the endometrium” • 4th Annual Scientific Meeting of the Obstetrical and Gynaecological Society of Hong Kong; Hong Kong; May 2014. “Genomics of the endometrial around the time of implantation” • Personalized Medicine in ART, Taiwanese Society for Reproductive Medicine; Taipei, Taiwan; May 2014. “Stem cells and its translation”, “Clinical application of the endometrial receptivity array: personalized medicine applied to implantation” • ALPHA 2014 10 th Biennial Conference; Antalya, Turkey; May 2014. “The endometrium: role of stimulation and adjuvants on receptivity” • Congreso Nacional de Obstetricia y Ginecología, Sociedad Panameña de Obstetricia y Ginecología; Panama, Panama; May 2014. “Evidencia actual sobre las células madre”, “Nuevas técnicas aplicadas en reproducción asistida” • 2nd Biomarkers Meeting in Personalized Reproductive Medicine: Biomarkers for the Assessment of Ovarian Reserve, Gametes, Embryos, Endometrium and Pregnancy in Health and Disease. Industrial Supported Lunch Symposium; Valencia, Spain; April 2014. “New developments on biomarkers of endometrial receptivity”, “Identifiying and personalizing the window of implantation: ERA clinical results” • Obstetrics and Gynecology Grand Round Series, Texas Children’s Hospital. Baylor College of Medicine; Houston, Texas, USA; April 2014. “A new theory for the maternal origin of preeclampsia” • 2014 Reproductive and Stem Cell Biology Retreat, Stanford University; Stanford University, USA; April 2014. “MicroRNAs secreted by the human endometrium act as transcriptomic regulators of the preimplantation embryo” • 2014 Fertilink. Individualized Controlled Ovarian Stimulation in ART; Gyeongju, Korea; March 2014. “Personalized medicine applied to endometrial receptivity and embryo transfer” • The Hong Kong Society for Reproductive Medicine; Kowloon, Hong Kong; March 2014. “Personalized medicine applied to endometrial receptivity and embryo transfer” • 16th World Congress of Gynecological Endocrinology. IV Congresso AIGE; Firenze, Itally; March 2014. “Endometrial reconstruction from stem cells” • The Best of ASRM & ESHRE; Cortina d’Ampezzo, Italy; February – March 2014. “Implantation failure: uterocentric” 2013 • VIII Congresso Paulista de Medicina Reprodutiva e Climatério, 25º ano Associação de Obstetrícia e Ginecologia de São Paulo (SOGESP); Sao Paulo, Brazil; December 2013. “State of the ART in the generation of artificial gametes”, “Genetic screening in patients with advanced age, male factor and implantation failure” • 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies; Boston, Massachusetts, USA; October 2013. “Clinical Applications of Endometrial Stem Cells” • 7th IVF Preceptorship: current practice in the 21 st century, Serono Symposia International Foundation; Madrid and Valencia, Spain; September 2013. “Challenge to improve the endometrial receptivity” • Advanced Reproductive Medical Treatments; Rome, Italy; September 2013. “Medical Strategy to optimize the implantation process” • Serono Symposia International Foundation, IVF Preceptorship: the state of the ART; Sao Paulo, Brazil; August 2013. “Scientific evidence and clinical approach to improve implantation” • 2013 Gordon Research Conference on Germinal Stem Cell Biology; Hong Kong; July 2013. “Direct conversion of human somatic cells to germ cells by genetic modification” • 61 st National Institute for Basic Biology Conference, Cellular community in mammalian embryogenesis; Okazaki, Japan; July 2013. “Blastomere fate during human pre- implantation embryo development”
71 • 30 th Annual Meeting, European Society of Human Reproduction and Embryology. Pre- Congres Course: Optimizing IVF outcome; London, UK; July 2013. “Improving implantation” • 14 th Internatonal Symposium for Immunology o Reproduction; Boston, Massachusetts, USA; May – June 2013. “Human endometrial receptivity: from the basic research to clinical translation” • International Conference on Genomics in Europe (ICG); Ghent, Belgium; June 2013. “Clinical Application of the endometrial receptivity array” • Latin Society of Biology and Reproductive Medicine (SOLAMER); Tunis, Tunisia; June 2013. “How to identify a receptive endometrium?” • Boston IVF Grand Rounds. Beth Israel Deaconess Medical Center, A major teaching hospital of Harward Medical School. Division of Reproductive Endocrinology and Infertility. (Video Conference); Boston, Massachusetts, USA; May 2013. “Human Endometrial Receptivity. From Research to Clinical Translation” ••• 12 th International Conference on Preimplantation Genetic Diagnosis, Clinical and Technical Aspects of PGD; Istanbul, Turkey; May 2013. “Is there effect of controlled ovarian stimulation on uterine receptivity and aneuploidy rates” • Serono Symposia International Foundation, Improving success in ART: how to define it and key strategies to get the best outcomes; Athens, Greece; April 2013. “The Uterine environment and endometrial receptivity: new frontiers for ART” • Merck Serono India. Fertiltiy Sceintific Advisory Board Meeting (Video conference); Mumbai, India; April 2013. “Implantation: Current concepts and practical applications” • 3rd Malaysian Reproductive Medicine Congress. ART as a continuum – looking to the future; Kuala Lumpur, Malaysia; April 2013. “Reconstruction of endometrium from human endometrial side population cells. Application in Asherman’s Syndrome”, “Human endometrial receptivity. From basic research to clinical translation” • 5th International IVI Congress. Reproductive Medicine and Beyond; Seville, Spain; April 2013. “Clinical application of the endometrial receptivity array” • 60 th Annual Meeting, Society for Gynecologic Investigation, Endometrial Satellite Symposium 2013 Contribution to Fertility; Orlando, Florida, USA, March 2013. “Clinical translation of endometrial transcriptomics” • 15th World Congress of Human Reproduction; Venice, Italy; March 2013. “Genomics and secretomic of endometrial receptivity. Clinical translation” • Latin Society of Biology and Reproductive Medicine (SOLAMER); Bourdeaux, France; January 2013. “How to identify a receptive endometrium?” • 2013 Reproductive and Stem cell biology retreat. Center for Human Embryonic Stem Cell Research and Education. Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology. Stanford University School of Medicine; Stanford, California, USA; January 2013. “Human endometrial receptivity from the transcriptomic research to the clinical translation in patients with implantation failure” 2012 • XXVI Annual German IVF Meeting; Cologne, Germany; December 2012. “ Profiling the gene signature of endometrial receptivity” • Emirates Obs-Gyn & Fertility Forum 2012; Dubai, United Arab Emirates; November 2012. “Endometrial stem cells – basic studies & application in Asherman Syndrome”, “New technologies in the IVF lab – video time lapse & vitrification” and “PGD with cGH arrays in 2012 – indications & results” • 67 th Annual Meeting of the American Society for Reproductive Medicine (ASRM); Orlando, USA; October 2012. “Generation of artificial gametes from pluripotent stem cells” • Beyond Frontiers in AR. Merck Serono; Mexico D.F., Mexico; September 2012. “Endometrial and myometrial somatic stem cells”, “Monitoring methods of human endometrial receptivity” and “Human embryonic stem cells” • Merck Serono Satellite Symposium During Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). Innovation and technologies in ART
72 to become best in class in take home baby rate; Istanbul, Turkey; July 2012. “Utilization of biomarkers of uterine receptivity in clinical practice” • 28 th Annual Meeting of the European Society of Human Reproduction and Embryology; Istanbul, Turkey; July 2012. “ Endometrial regeneration” • Born after ART: from the laboratory towards the delivery room; Kos, Greece; June 2012. “Implantation and obstetric complications” • Federazione Italiana delle Società Scientifiche della Reproduzione; Riccione, Italy; May 2012. “Endometrial Receptivity: monitoring methods” • Serono Symposia International Foundation, The multi-factorial equations of ART: defining and maximizing success in pregnancy rates; Sorrento, Italy; May 2012. “Other potential non-invasive technologies to assess the most receptive endometrium: lipidomics” • World Congress on Building Consensus in Gynecology, Infertility and Perinatology; Barcelona, Spain; May 2012. “Invasive diagnosis: endometrial receptivitiy array” • ALPHA 2012 - 9th Biennial Conference, Merck Serono Symposium; London, UK; April 2012. “Lipidomics: A new Non-Invasive Diagnostic Method of Human Endometrial Receptivity” • Grant for Fertility Innovation: Developing Innovative Technologies to Become Best in Class in Take Home Baby Rate. Merck Serono Symposia, During the 1 st Biomarker Meeting in Reproductive Medicine: Emergence of a New Field; Valencia, Spain; March 2012. “Lipidomics: A non-invasive diagnostic method of human endometrial receptivity” • 1st Biomarker Meeting in Reproductive Medicine: Emergence of a New Field; Valencia, Spain; March 2012. “Profiling the gene signature of endometrial receptivity. Clinical results” • 15 th World Congress of Gynecological Endocrinology; Florence, Italy; March 2012. “Modeling Human Endometrial Decidualization from the Interaction between Proteome and Secretome” • University of Oxford, Institute of Reproductive Sciences; Oxford, UK; February 2012. “Clinical translation of genetics in endometrial receptivity and embryo assessment” 2011 • Serono Symposia International Foundation, IVF Preceptorship: current practice in the 21st century; Madrid, Spain; December 2011. “Scientific evidence and clinical approach to improve implantation” • Expert Meeting Contraception on Demand; Berlin, Germany; November 2011. “Potential targets for Contraception on Demand: Endometrium” • Serono Symposia International Foundation, advanced workshop on oocyte retrieval and embryo transfer; Dubai, United Arab Emirates; November 2011. • Nature Group Conferences, The Herrenhausen Symposium on Reproductive Biology; Kloster Seeon, Munich, Germany; October 2011. “Clinical Issues” • A Window into the Reproductive Era Research; Milan, Italy; October 2011. “How endometrial secretomics can help in predicting implantation” • SMART VII, Merck Serono Meeting in ART; Valencia, Spain; May 2011. “PGD & PGS cases”, “State of the art of the genetic diagnostic techniques used on the embryos and their clinical relevance” • 13 th Congress of the French Reproductive Medicine Society; Paris, France; May 2011. “Autologous coculture of embryos: an old new thing?” • Serono Symposia International Foundation, Reproductive ageing-a basic and clinical update; Taormina, Italy; April 2011. “Generation of artificial gametes from stem cells” • 2nd International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissue and Organs (CRYO); Valencia, Spain; April 2011. “Guidance for banking and supply of human embryonic stem cell lines for research purposes” • 4th International Instituto Valenciano de Infertilidad (IVI) Congress; Valencia, Spain; April 2011. “Endometrial stem cells and its translation” • 58 th Annual Meeting of the Society for Gynecologic Investigation (SGI); Miami Beach,
73 USA; March 2011. “Germ Cells Differentiation from Human Embryonic Stem Cells” • PEBS 2010-2011. Cancer Epigenetic and Biology Program. Bellvitge Biomedical Research Institut. IDIBELL, L´hospitalet de Llobregat, Barcelona, Spain; January 2011. “Adult vs embryonic vs induced pluripotent stem cells” 2010 • 66 th Annual Meeting of the American Society for Reproductive Medicine (ASRM); Denver, USA; October 2010. “Stem Cells in Reproduction” ••• Instituto de Ginecología y Fertilidad (IFER), XVII convivencia en infertilidad; Buenos Aires, Argentina; September 2010. “Conferencia Perspectivas futuras en Medicina Reproductiva”, “Avances en el diagnóstico de la receptividad endometrial”, “Diagnóstico no invasivo de calidad embrionaria y aneuploidias”, “Células madre en endometrio y miometrio. Implicancias en endometriosis y miomas” • European Society of Human Reproduction and Embryology Campus 2010; Basic course on “Update on pluripotent stem cells (hESC and iPS)”; Valencia and Barcelona, Spain; February and November 2010. “New hESC derivation strategies maintaining embryo viability” • The 1 st International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive cells, Tissue & Organs; Valencia, May 2010. “Adults stem cells vs. Embryonic stem cells” • SKLRB Symposia on Frontiers in Periimplantational Biology; Beijing, China; May 2010. “Human endometrial CD98 is essential for blastocyst adhesion” • 2nd Annual LIFE Advanced ART Course; Beijing, China; May 2010. “Derivation of gametes from stem cells”, “Endometrial receptivity diagnosis: What is new?” • Evian Annual Reproduction Meetings, Contemporary genetic technologies and human reproduction; Evian, France; April 2010. “Genetics of endometriosis”, “Effect of ovarian stimulation protocols on the endometrium” 2009 • Challenges in Reproductive Medicine. Artemis Health Institute; Gourgaon, India; December 2009. “Endometrial factors governing implantation failure”, “Effect of ovarian stimulation protocols on the endometrium” • Serono Symposia International Foundation, IVF Preceptorship: current practice in the 21st century; Madrid, Spain; December 2009. “Future perspective in ART” • Scitech Europe 09. Innovation Across Europe; Brussels, Belgium; November 2009. “Embryonic stem cells for therapy” • Serono Symposia International Foundation, Defining patient subgroups to personalize infertility treatments; Stockholm, Sweden; September 2009. “Why and how to predict the endometrial status” • Serono Symposia International Foundation, Fertility Academia. Advanced Course in Human Reproduction and Embryology; Amsterdam, The Netherlands; June 2009. “Future perspectives in ART” • 3rd International Instituto Valenciano de Infertilidad (IVI) Congress; Valencia, Spain; April 2009. “Generation of artificial gametes from stem cells” • UK- Spain Stem Cells Workshop: from Bench to Clinic; London, UK; March 2009. “hESC derivation maintainig embryo viability” • New Frontiers in Fertility: Lisbon, Portugal; February 2009. “Endometrial receptivity: monitoring and managing” • Keystone Symposia on Molecular and Cellular Biology. Frontiers in Reproductive Biology and Regulation of Fertility; Nuevo Mexico, USA; February 2009. “Pathways Governing Human Endometrial Receptivity” 2008 • XXXVI World Congress of the International College of Surgeons, Vienna, Austria; December 2008. “Stem Cells and Regenerative Medicine – Current status” • Celebration 30 years of IVF: New Technology in Reproductive Medicine; Paris, France; November 2008. “Where are we now in the understanding of endometrial stem cells?” • International Workshop on Infertility and Assisted Reproduction; Geneva, Switzerland;
74 November 2008. “Endometrial stem cells”, “Endometrial receptivity” • 64 th Annual Meeting, American Society for Reproductive Medicine (ASRM); San Francisco, USA; November 2008. “Success and failure of embryo implantation in ART” • Optimal Infertility Management Issues and innovations; Tel Aviv, Israel; September 2008. “Basics and clinical translation of OHSS research”, “What is new from the endometrium that may impact ART?” • 13th World Congress of Ginecological Endocrinology. International Society of Gynecological Endocrinology; Florence, Italy; March 2008. “The creation of gametes from stem cells” • International Society of Mild Approaches in Assisted Reproduction; London, UK; April 2008. “In vivo development of human embryos in IVF” • 55 th Annual Meeting of the Society for Gynecologic Investigation (SGI); San Diego, USA; March 2008. “Embryonic Stem Cells” • Updates in Infertility treatment; Cape Town, South Africa; January-February 2008. “Human embryonic stem cells. New times, new opportunities” 2007 • Clinica Mangiagalli, Universit Degli Studi di Milano, La gravidanza da riproduzione assistida: fattori di rischio e management; Milan, Italy; November 2007. “The embryo and its implantation in spontaneous and assisted pregnancies” • 2nd International Summit on Reproductive Medicine. Society for Gynecologic Investigacion (SGI); Valencia, Spain; November 2007. “Adult progenitor stem cell population in the human and mice endometrium” • Serono Symposia International Foundation, IVF Preceptorship: current practice in the 21st century; Madrid, Spain; October 2007. “Implantation” • 2nd International Congress of the Instituto Valenciano de Infertilidad (IVI); Barcelona, Spain; Septiembre 2007. “Stem cells in reproductive medicine” • Royan International Twin Congress: 8th Congress on Reproductive Biomedicine and 3rd Congress on Stem Cells Biotechnology; Teheran, Iran; September 2007. “Stem Cells in reproductive medicine”, “Genomics of endometrial receptivity” • Skibo event, The Carnegie Club, Skibo Castle; Dornoch, Sutherland, Scotland; June 2007. “Stem Cells, therapeutic applications and the future of regenerative medicine” • Anglo-Spanish Workshop on stem cells in disease and therapy; Madrid, Spain; May 2007. “Policies, strategies and objectives of public cell line banks” • 1st International Symposium in Genetics and Assisted Reproduction Techniques. Eurogene Genetics Lab. Biogenetics, Molecular Biology Lab; Athens, Greece; May 2007. “PGD in recurrent miscarriage of unknown aetiology: identification of good prognostic factors”, “Genomics of endometrial receptivity” • XIX World Congress on Fertility & Sterility; Durban, South Africa; April-May 2007. “Adult stem cell in the uterus” • 2nd World Congress on Gender-Specific Medicine and Aging; Rome, Italy; March 2007. “Gender issues in the differentiation of embryonic stem cells to gametes” • 17 th Scientific Meeting of Belgian Society for Reproductive Medicine; Zemst, Brussels; February 2007. “Genomic impact of controlled ovarian stimulation in human endometrial receptivity” 2006 • Frontiers in Biomedical research; Hong Kong; December 2006. “Human embryonic stem cells, facts and hopes” • Workshop on reproductive medicine. Hospital of Sun Yat-Sen University; Guangzhou, China; December 2006. “Stem cells in reproductive medicine”, “What are the markers of endometrial receptivity?” • Biosymposia Inc, Endometrial Biology and Pathologies; San Francisco, USA; November 2006. “Altered gene profiles following ovarian hyperstimulation” • 2nd Course on Molecular Biology for Reproductive Medicine Specialists; Siena, Italy; September 2006. “Mechanism of human embryonic implantation” • 15th Simpson Symposium: The Queen’s Medical Research Institute, University of Edinburgh; Edinburgh, Scotland; September 2006. “hESC derivation in feeder-free,
75 xeno-free and embryo-friendly conditions” • Serono Symposia International Foundation. ART in the 21 st century: a time for reflection and new horizons; Amsterdam, The Netherlands; November 2006. “What are the markers of endometrial receptivity?” • Instituto Quinteño de Infertilidad; Quito, Ecuador; July 2006. “Implantación embrionaria”, “Receptividad endometrial humana”, “Células madre, expectativas y limitaciones” • Serono Symposia International Foundation, Human implantation: the new frontiers of human assisted reproductive technologies; Erice, Italy; May 2006. “Genomics of human endometrial receptivity” • Serono Symposia International Foundation, Therapeutic potential of stem cells in reproductive medicine; Valencia, Spain; March – April 2006. “Adult stem cells in the uterus”, “Adult stem cells in the human ovary”, “hESC culture in feeder-free, xeno-free conditions” • 53 rd Annual Meeting of the Society for Gynecologic Investigation (SGI), Endometrial satellite symposium. Toronto, Canada; March 2006. “Genomics of endometrial receptivity”, “Only nonhuman primate research can clarify the “black box” of embryonic-endometrial implantation in vivo in humans” • 12th World Congress of Gynecological Endocrinology; Florence, Italy; March 2006. “Stem cells: the future ahead” • Evian Annual Reproduction Meetings, Expert meeting on implantation research. Evian, France; February 2006. “Genomic impact of COH in human endometrial receptivity” • Updates in infertility treatment 2006; Cape Town, South Africa; January 2006. “Endometrial features and embryo transfer outcome” 2005 • Serono Symposia International Foundation, Endometrium and embryo implantation; Paris, France; December 2005. “ The impact of controlled ovarian stimulation in human endometrial receptivity” • New Developments in Reproductive Medicine. Cátedra Santiago Grisolía, Fundación Ciudad de las Artes y las Ciencias; Valencia, Spain, October 2005. “Embryonic stem cell research in Spain” • In Vitro Testing Industrial Platform; Rotterdam, The Netherlands; October 2005. “Ethical aspects of using human stem cells” • Sociedad Uruguaya de Reproducción Humana (SURH) y Taller Regional (Argentina/Paraguay/ Uruguay) de la Red Latinoamericana de Reproducción Asistida (Redlara); Colonia del Sacramento, Uruguay; September – October 2005. “Diagnosis and treatment of implantation failure”, “Advances in understanding of the biology of embryo implantation” • European Society of Human Reproduction and Embryology (ESHRE) organized by Special Interest Group Reproductive Endocrinology, 1 st Course on Molecular Biology for Reproductive Medicine Specialists; Siena, Italy; September 2005. “Endometrial receptivity, embryo-endometrial interaction and implantation” • Serono Symposia International Foundation, New frontiers in reproductive medicine: clinical and laboratory advances; Siem Reap, Cambodia; September 2005. “Causes and diagnosis of implantation failure” • 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics; Istanbul, Turkey; May 2005. “Factors that determine success on oocyte donation cycles”, “Molecular basis of implantation” • New trends in Human Reproduction 2005, Chang Gung Memorial Hospital and School of Medicine; Taipei, Taiwan; May 2005. “Genome wide analysis of endometrial receptivity: the impact of ovarian stimulation” • Multiple Gestation: Expert Meeting, Bertarelli Foundation; Valencia, Spain; April 2005. “Proteomic pattern secreted by viable blastocyst as a diagnostic tool to accomplish single births after IVF” • 1st International Congress of the Instituto Valenciano de Infertilidad (IVI); Valencia, Spain; April 2005. “Derivation of the first embryonic stem cell lines in Spain”
76 • 4th Mediterranean Society for Reproductive Medicine; Cannes, France; April 2005. “Genomic and proteomic of implantation” • Federation of Biomedical Scientific Societies in The Netherlands; Leiden, The Netherlands; February 2005. “Embryonic-endometrial interactions at implantation in humans” 2004 • European Society of Human Reproduction and Embryology (ESHRE) Campus 2004, GnRH antagonist in IVF; Brussels, Belgium; December 2004. “Endometrial development on GnRH antagonist cycles” • Swiss Society for Reproductive Medicine; Bern, Switzerland; November 2004. “Which treatments are transferred to other countries? How is the collaboration with a centre abroad organized?” • Instituto de Ginecología y Fertilidad (IFER), XIII convivencia en infertilidad; Buenos Aires, Argentina; October 2004. “Fallas recurrentes de implatación en FIV”, “Aplicaciones prácticas del tratamiento con antagonistas GnRh”, “Células madre en medicina reproductiva”, “Receptividad uterina”, “La transferencia embrionaria. ¿Cómo se debe realizar?” • 1st International Congress of Reproductive Medicine. Society of Reproductive Medicine-Turkey; Istanbul, Turkey; September 2004. “Genomics in endometrial receptivity”, “Leptin and endometriosis” • Serono Symposia International Foundation; From oocyte to embryo: a pathway to life; Stressa, Italy; September 2004. “Leptin system in embryo development and implantation” • Medifertil Stem Cells Bank; Bogota, Colombia; August 2004. “Células madre embrionarias. Expectativas e incertidumbres” • 24 th Annual Meeting of American Society for Reproductive Immunology; Missouri, St. Louis, USA; June 2004. “Embryo aneuploidy screening: a diagnostic tool for unexplained recurrent miscarriage” • 4th World Congress on Ovulation Induction; Bologna, Italy; May 2004. “Use of recombinant LH”, “Pathophysiology of embryo implantation” • International Federation of Fertility Societies, World Congress on Fertility and Sterility; Montreal, Canada; May 2004. “Implantation and uterine receptivity” • 52 nd Annual meeting, Pacific Coast Reproductive Society; Rancho Mirage, USA; April- May 2004. “Blastocyst and uterine interactions at implantation”, “Future prospects for REI” • Centre for Reproductive Medicine and Gleneagles IVF Centre; Singapore; April 2004. “Role of endometrium in implantation-special note on endometrial culture-Recent advances”, “Future directions in ART” • 11 th World Congress of Gynecological Endocrinology; Florence, Italy; February 2004. “Genomics of endometrial receptivity” 2003 • Serono Symposia International Foundation, Ovum Donation and beyond: frontiers in Medicine; New York, USA; December 2003. “International Ovum Donation” • European Society of Human Reproduction and Embryology (ESHRE), Course Special Interest Groups Reproductive Genetics and Early Pregnancy; Amsterdam, The Netherlands; December 2013. “Human endometrial receptivity; a wide-genome analysis” • TWIN-Meeting Alpha-Andrology 2003; Antwerp, Belgium; September 2003. “Implantation processes of the human embryo” • Serono Symposia International Foundation, From Genetics to Implantation and Early Fetal Development in Infertile Couples; Milan, Italy; October 2003. “Hormonal and embryonic regulation of human implantation” • Serono Symposia International Foundation, Reproductive Ageing; Palma de Mallorca, Spain; September 2003. “Embryo development in vitro in older patients. The IVI experience” • Imperial College, New Horizons in Recurrent pregnancy loss; London, UK; September
77 2003. “Embryo aneuploidy screening- a diagnostic tool for unexplained recurrent miscarriage” • III International workshop on Human Implantation: Discovery in the Reproductive Tract in Health and Disease Using Genomics/ Proteomics. Serono Foundation for the Advancement of Medical Science; Madrid, Spain; June 2003. “Human endometrial receptivity, a wide-genome analysis” • International Conference on the Female Reproductive Tract; Frauenchiemsee, Germany; May-June 2003. “Genomic of human endometrial receptivity” • 2nd Mediterranean Congress of Reproductive Medicine. Lessons gained from 25 years of IVF; Alexandria, Egypt; May 2003. “Human Endometrial Receptivity- a genomic approach” • Fortpflanzungsmedizin aktuell. Was gibt es Neues in Klinik und Labor?; Donnerstag, Baden; Switzerland; May 2003. “Human Implantation. From science to clinical practise”, “Die schwierige ovarielle stimulation. Ursachen und neue Therapiekonzepte“ • Workshop funded by the Wellcome Trust in collaboration with The Royal Society of Edinburg and supported by the Munro Kerr Society; Edinburgh, Scotland; January 2003. “The importance and investigation of cell-cell interaction: human blastocyst- endometrial/epithelial interaction” 2002 • Federación Latinoamericana de Sociedades de Esterilidad y Fertilidad; Montevideo, Uruguay; November 2002. “Chromosomal abnormalities in recurrent abortion”, “Adolescence preservation of the reproductive future. Criopreservation of the ovarian tissue” • 1st Mediterranean Congress on Reproductive Medicine; Taormina, Sicily, Italy; November 2002. “The leptin system in human implantation” • 5th Workshop on Assisted Reproductive Techniques. Reproductive Medicine Research Center of 1 st Affiliated Hospital of Sun Yat-Sen University; Guangzhou, China; November 2002. “Molecular mechanism of implantation and assessment of uterine receptivity”, “Embryonic regulation of endometrial molecules in human implantation” • Centro de Estudios Santa Joana Pro Matre; São Paulo, Brazil; August 2002. “Meios de cultura comerciais vs co-culturas”, “hCG recombinante vs urinário”, “Indução da ovulação com Cetrotide: Resultados” • Asociación Colombiana de Fertilidad y Esterilidad; Bogota, Colombia; 2002. “Pasado, presente y futuro de la T.R.A.”, “Receptividad uterina e implantación embrionaria”, “Importancia del diagnostico genetico preimplantatorio” • Serono Symposia International Foundation, Embryo Implantation: Cellular changes from bench to bedside; Connecticut, USA; July 2002. “In vitro models for human implantation: lessons learned” • 18th Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE); Vienna, Austria; July 2002. “Preimplantation genetic diagnosis in implantation failure and recurrent pregnancy loss” • Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Instituto de Salud Carlos III; Madrid, Spain, June 2002. “Human embryonic stem cells from non- viable human embryos” • XXII Annual Meeting of the American Society for Reproductive Immunology (ASRI), Adapting New Technologies to Reproductive Immunology; Chicago Illinois, USA; June 2002. “Embryonic regulation of endometrial molecules in human implantation” • Congreso Colombiano de Obstetricia y Ginecología; Cartagena de Indias, Colombia; April 2002. “Nuevos avances en el síndrome de hiperestimulación ovárica”, “Reproducción Asistida” • Serono Symposia USA, Inc., Toward optimizing ART: a tribute to Howard and Georgeanna Jones; Williamsburg, Virginia, USA; April 2002. “Uterine receptivity issues” • III Congreso Nacional Avances en la ginecología y obstetricia panameña en el siglo XXI; Panama; March 2002. “Manejo del fallo de implantación embrionaria”, “Presente y futuro de la reproducción asistida”, “Nuevas tecnologías de manipulación embrionaria”
78 • Advances In Infertility Treatment; Fort Lauderdale, Florida, USA; January 2002. “Embryonic regulation of endometrial receptivity in humans” 2001 • 9th World Congress of Gynecological Endocrinology; Hong Kong, China; December 2001. “Leptin system in the human maternal-embryonic interface” • 57 th Annual Meeting of the American Society for Reproductive Medicine (ASRM); Orlando, Florida, USA; October 2001. “Human Implantation: What do we need to know?”, “Basic Research on the molecular mechanisms regulating OHSS” • IV Congress of the European Society of Gynaecology; Barcelona, Spain; October 2001. “Future possibilities for improving implantation” • XXVIII International Symposium Fertility 2001, Institut Universitari Dexeus; Barcelona, Spain; October 2001. “Fracaso implantatorio” • 1er Simposio Internacional sobre Medicina de la Reproducción Humana; Buenos Aires, Argentina; September 2001. “Manejo del fallo de implantación” • 5º Congreso Colombiano de Fertilidad y Esterilidad; Barranquilla, Colombia; August 2001. “Presente y futuro de la reproducción asistida”, “Manejo del fallo de implantación”, “Cocultivos”, “Papel de la progesterona en la ventana de implantación” • II International Workshop on Human Implantation: Recent Advances & Clinical Aspects; Mardrid, Spain; May 2001. “Human endometrial receptivity. Gene regulation” • Human Blastocyst 2001. Genk Institute for Fertility Technology & αlpha, the International Society for Scientists in Reproduction; Genk, Belgium; April 2001. “Embryo-maternal dialogue”, “Co-culture of blastocysts” • Preimplantation Genetic diagnosis (PGD). International experiences and national expectations; Ahrensburg, Germany; March 2001. “PGD by fluorescence in-situ hybridization: possibilities and pitfalls” 2000 • Sociedad de Ginecología y Obstetricia de la Ciudad de La Plata, Colegio de Médicos – Distrito I y Laboratorio ELEA; La Plata, Argentina; December 2000. “Transferencia de blastocistos en reproducción asistida” • Sociedad Argentina de Biología; Buenos Aires, Argentina; December 2000. “Moléculas de reconocimiento en la implantación embrionaria” • Serono Symposia International Foundation, unraveling topics in reproductive medicine; Santiago de Chile, Chile; December 2000. “Endometrial receptivity. Molecular and clinical aspects” • Serono Symposia International Foundation, Reproductive competence: Pathophysiology and therapeutic interventions; Santiago de Chile, Chile; November 2000. “Paracrine dialogue in human implantation” • Geman IVF Center Federation; Hamburg, Germany; November 2000. “Embryonale aspekte der implantation“ • Third World Congress on Ovulation Induction; Bologna, Italy; October 2000. “The role of the endothelium in the pathogenesis of ovarian hyperstimulation syndrome (OHSS)”, “Luteal function during leuprorelin administration in ovulation induction” • Human implantation, basic and clinical aspects; Palermo, Italy; October 2000. “Ovarian stimulation and endometrial receptivity”, “Basic aspects of implantation and its disorders. Biochemical dialogue between embryo and endometrial tissue” • New York University, School of Medicine, Human Fertility And Reproduction: The Oocyte, The Embryo And The Uterus; New York, USA; October 2000. “Embryonic regulation of endometrial molecules in implantation” • European Society of Human Reproduction & Embryology (ESHRE) Campus Symposium; Tel-Aviv, Israel; September 2000. “Basic aspects of implantation and its disorders” • The Early Human Life; Vatican City; September 2000. “The local factors in the implantation” • Pontificia Universidad Javeriana, Avances en Medicina Reproductiva; Bogotá, Colombia; August 2000. “Presente y futuro de las técnicas de reproducción asistida”, “Diagnóstico genético preimplantación en mujeres con aborto habitual”, “Implantación
79 Embrionaria: aposición, adhesión e implantación” • Imperial College School of Medicine. Division of Paediatrics, Obstetrics & Gynaecology; London, UK; June-July 2000. “Embryo aneuploidy in recurrent pregnancy loss” • 16th Annual Meeting European Society of Human Reproduction and Embryology (ESHRE); Bologna, Italy; June 2000. “Critical assessment of human blastocyst transfer” • 10th International Conference on Prenatal Diagnosis and Therapy; Barcelona, Spain; June 2000. “PGD and repeated abortion” • 10º Congreso Sociedad Argentina de Esterilidad y Fertilidad; Buenos Aires, Argentina; 2000. “Marcadores de implantación”, “Fisiología de la implantación: diálogo embrión- endometrio” • International Symposium on ART and the Human Blastocyst. Serono Symposia USA; Dana Point, USA; March – April 2000. “Embryo-Maternal Dialogue” • International Society of Reproductive Endocrinology, Endocrine basis of reproductive function; Tampa, USA; January 2000. “Basic aspects of implantation and its disorders”
1999 • Société Médecine de la Reproduction ; Paris, France ; December 1999. “Existe-t-il une corrélation entre maturation ovocytaire et aptitude de l’endomètre à nider? » • 6th Annual Meeting of the Middle East Fertility Society; Southern Sinai, Egypt; November 1999. “How to improve implantation in ART” • 3rd Congress European Society of Gynecology; Bruges, Belgium, October 1999. “Cytokines and implantation” • Instituto de Ginecología y Fertilidad (IFER), XIII convivencia en infertilidad; Buenos Aires, Argentina; November 1999. “Pérdidas embrionarias precoces y reiteradas de causa cromosómica”, “Cómo mejorar la calidad embrionaria en Fertilización Asistida”, “El endometrio en ciclos de estimulación ovárica”, “Regulación embrionaria de moléculas endometriales”, “Fisiología y fisiopatología de la implantación”, “Reflejo de los avances de la investigación en las técnicas de Fertilización Asistida” • European Meeting of Immunology and Reproduction; Roma, Italy; October 1999. “Embryonic Implantation” • German Society for Reproductive Medicine; Rolduc/Aachen, Germany; October 1999. “Coordinated regulation of endometrial epithelial apoptosis by the human embryo” • Sociedad Latina de Biología y Medicina de la Reproducción; Barcelona, Spain; October 1999. “Fisiología del proceso implantatorio” • Société Française d’Endocrinologie; Bourdeaux, France ; October 1999. “L’approche endométriale de la contraception » • 10th Reinier de Graaf Symposium; Zeist, The Netherlands; September 1999. “Preimplantation assessment of aged embryo’s” • 7th World Congress of gynecological endocrinology, The International Society of Gynecological Gndocrinology; Buenos Aires, Argentina; April 1999. “Normal human implantation”, “Cytokine crosstalk between embryo and endometrium”, “Implantation and its disorders: how to improve implantation in ART” • University of Lund, Workshop on Blastocyst Development and Early Implantation; Lund, Sweden; April 1999. “Embryonic regulation of endometrial epithelial molecules” • VI Congreso de la Federación Latinoamericana de Sociedades de Esterilidad y fertilidad. I Congreso panameño de infertilidad y endoscopia ginecológica. II Foro latinoamericano de reproducción humana; Panama, Republic of Panama; March 1999. “Receptividad uterina, aspectos básicos y clínicos”, “Implantación”, “Alteraciones cromosómicas de novo en los embriones de las pacientes con abortos de repetición” • Ares-Serono Foundation, International Workshop on Human Implantation: Recent Advances & Clinical Aspects; Valencia, Spain; March 1999. “Embryonic regulation of adhesion molecules and chemokines” • ART 2000- New Horizons; Aschau/Munich, Germany; January 1999. “Molecular and
80 cellular developments in implantation research” 1998 • Workshop on Human Implantation; Geneva, Switzerland; November 1998. “Endometrial competency including ultrastructure” • 18 Congreso Brasileiro de Reproducao Humana; Porto Alegre, Brazil; November 1998. “How to increase implantation rates in assisted reproduction”, “Basics aspects of human implantation” • Flemish Society of Gynecology, Brussels, Belgium; October 1998. “New concepts of Implantation” • French National Institute of Health and Medical Research, Aix Les Bains, France; September-October 1998. “The IL-1 system and embryonic implantation” • European Society of Human Reproduction & Embryology (ESHRE); Tel Aviv, Israel; September 1998. “Long term co-culture to the blastocyst stage: coculture versus synthetic medium” • New Frontiers in Infertility Management; Bangalore, India; July 1998. “Endometrial status as a predictor of IVF”, “Prognostic factors in IVF-ET” • Samsung Medical Center; Seoul, Korea; July 1998. “Endocrine factors affecting embryonic implantation in human”, “Molecular interactions between embryo and endometrium in implantation” • Société Française d´Endocrinologie; Paris, France; June 1998. “Implantation » • II Congreso argentino de endocrinología ginecológica y reproductiva. Sociedad Argentina de Endocrinología Ginecológica y Reproductiva (SAEGRE); Buenos Aires, Argentina; May 1998. “Estrategias para mejorar la implantación”, “Implantación. Aspectos básicos. Comunicación entre embrión y endometrio” • International Congress on Ovulation Induction and Menopause 98; Antalya, Turkey; May 1998. “The detrimental effect of ovulation induction on fertility”, “Apoptosis in Reproductive Biology. An overview (Key note lecture)”, “Cytokines, adhesion molecules and invasive proteinases: The missing paracrine-autocrine link in embryonic implantation (Keynote lecture)” • International Symposium on Reproductive Medicine, Co-Sponsored by ASRM ESHRE – IVI. State of the Art of Human Implantation. Basic and Clinical Aspects; Madrid, Spain; May 1998. “Update of the role of IL-1 system in human implantation”, “Co- cultures II. Using primary cultures. Endometrial epithelium” • New developments in diagnosis and treatment of infertility; Antwerpen, Belgium, May 1998. “State of the art lecture. Endometrial receptivity” • 20 years of IVF. A Celebration Meeting; Marrakech, Morocco; March 1998. “Cross-talk between uterus and embryo” • 6th Congress of the International Society of Gynecological Endocrinology (ISGE); Crans-Montana, Switzerland; March 1998. “Embryonic implantation in high responder patients. How to improve it?” 1997 • Fertility Society of Australia; Adelaide, Australia; December 1997. “Immunology of implantation” • Genes and Environment in Human Reproductive Disorders. Serono Colloquia Australasia; Adelaide, Australia; November – December 1997. “Recurrent Pregnancy Loss. Maternal or/and Embryonic Fault?” • Sociedad Chilena de Reproducción y Desarrollo; La Serena, Chile; August 1997. “Rol del sistema de la IL-1 en la implantación” • Universidad de Chile, Avances en Reproducción Humana; Santiago de Chile, Chile; August 1997. “Desarrollo embrionario e implantación en pacientes con endometriosis”, “Señales embrionarias en la implantación humana”, “Bases fisiológicas y moleculares de la implantación. Rol del sistema interleuquina” • Asociación Colombiana de Fertilidad y Esterilidad, Controversias en Reproducción Humana; Santa Fe de Bogotá, Colombia; August 1997. “Cocultivos en reproducción asistida”, “Conceptos actuales en la endometriosis”, “Bases Moleculares de la Implantación”
81 • International Workshop on Paracrine Mechanisms in Female Reproduction; Seville, Spain; June 1997. “Cytokines and embryo implantation” • 4th Bourn Hall Meeting on Reproductive Medicine; Cambridge, UK, June 1997. “Molecular Interactions between embryo and uterus” • International Meeting on Infertility and Assisted Reproductive Technology; Porto Cervo, Italy; June 1997. “Adhesion proteins in implantation” • World Congress on In Vitro Fertilitation & Assisted Reproduction; Vancouver, Canada; May 1997. “Molecular mechanisms of implantation” • VII Symposium Internacional del IVI, la capacidad reproductiva del varón; Valencia, Spain; February 1997. “Anticoncepción preimplantatoria” • II Symposium Internacional de Ginecología Endocrinológica y Menopausia; Madrid, Spain; January 1997. “Ciclos estimulados e implantación embrionaria” 1996 • Fundación Argentina para el Tratamiento de la Esterilidad; Buenos Aires, Argentina; November 1996. “Legislación en la comunidad económica europea”, “Factores endometriales y embrionarios de posible aplicación clínica para mejorar la implantación embrionaria”, “Citokinas e implantación”, “Importancia del estradiol en la implantación embrionaria de las altas respondedoras”, “Implantación embrionaria, fisiología y fisiopatología” • Symposium Internacional Actualización sobre Función ovárica y sus trastornos. Hospital Universitario La Fe; Valencia, Spain; October 1996. “Fisiología del endometrio e implantación” • 5th World Congress of Gynecological Endocrinology; Barcelona, Spain; October 1996. “Cytokines-adhesion molecules-invasive proteinases. The missing paracrine /autocrine link in embryonic implantation” • XVI Annual Meeting, American Society for Reproductive Immunology (ASRI); Knoxville, Tenesse, USA; June 1996. “The IL-1 system and human implantation” • IXth World Congress on Human Reproduction and Vth World Conference on Fallopian Tube in Health and Disease; Philadelphia, USA; June 1996. “Recent research on the IL-1 system and implantation” • European Meeting on Medically Assisted Procreation; Siena, Italy; May 1996. “Adhesion molecules in embryonic implantation” • Materno-Fetal Immunobiology Group (MFIG) Workshop British Society of Immunology; Bristol, England, April 1996. “Cytokines in implantation” • Second Mediterranean Gynecological Club Conference: Controversies in Obstetrics and Gynecology; Eilat, Israel; March 1996. “Should we screen for infectious disease in the case of repeated abortion?” • 4th International Symposium on GnRH Analogues in Cancer and Human Reproduction; Geneva, Switzerland; February 1996. “GnRHa in IVF. Targeting the corpus luteum function” 1995 • Simposio Internacional de Histeroscopia; Barcelona, Spain; October 1995. “Histeroscopia diagnóstica (Video)”, “Histeroscopia diagnóstica. Material e Indicaciones” • 15th World Congress on Fertility and Sterility; Montpellier, France; September 1995. “Immunological aspects of implantation failure (IL1)” • Instituto de Ciencias de la Salud; Medellin, Colombia; August 1995. “Implantación en reproducción asistida”, “Complicaciones de la reproducción asistida” • 11th Annual Meeting of the European Society of Human Reproduction & Embryology (ESHRE); Hamburg, Germany; June – July 1995. “Interleukins” • European Association of Gynecologists and Obstetricians; Monaco; March-April 1995. “Molecular mechanism of endometrial tumori-genesis” • European Society of Human Reproduction & Embryology (ESHRE), Symposium on Reproductive Medicine "Maternal-Embryo Interactions"; Valencia, Spain; March 1995. “Interleukin-1 system as a paradigm of dialogue between embryo and endometrium in implantation”
82 • V Simposium Internacional of the Instituto Valenciano de Infertilidad (IVI); Valencia, Spain; March 1995. “Stromal and epithelial endometrial cell culture” 1994 • 4th World Congress on Endometriosis; Salvador de Bahia, Brazil; May 1994. “The role of the IL-1 system in human implantation: Evidence for alteration of the IL-1 system in endometriosis" • Early embryo development, uterus preparation and role of cytokines in implantation and labour; Annecy, France; May 1994. “The role of IL-1 β system during implantation” 1991 • I Symposium Internacional del Instituto Valenciano de Infertilidad: Endoscopia Operatoria; Valencia; Spain; May 1991. “¿Es conveniente el tratamiento conservador del embarazo ectópico?” 1990 • III Symposium Hispano-Luso-Brasileiro de Ecografía en Obstetricia y Ginecología. I Symposium Hispano-Luso-Brasileiro de Reproducción Asistida; Lisbon, Portugal; November 1990. “Reducción embrionaria transvaginal” 1989 • II Symposium Hispano-Luso-Brasileiro de Ecografía Obstétrico-Ginecológica; Salvador de Bahía, Brazil; July 1989. “Patología de la vesícula vitelina”, “Endosonografía del embarazo ectópico”, “Endosonografía del cáncer ovárico” 1987 • Spanish/German Society of Obstetrics and Gynecology; Valencia, Spain; April 1987. “Amniocentesis precoz y biopsia corial” 1985 • Reunión Hispano-Portuguesa de las Secciones de Ecografía de la Asociación Ginecológica Española y de la Sociedad Portuguesa de Obstetricia y Ginecología; Valencia, Spain; December 1985. “Cirugía fetal intraútero en la patología renal”, “Cirugía fetal intraútero en la hidrocefalia”
83 Invited Seminars 2017 / Symposium • V Jornadas IVI Sevilla. La Reproducción Asistida: Superando las Barreras Presentations Fisiológicas; Sevilla, España; November 2017. “Reproducción Asistida: Presente y National Futuro” Invitations 2016 • IV Simposio nacional fertilidad hoy; Palma de Mallorca, Spain; April 2016. “Avances tecnológicos aplicados a la Medicina Reproductiva: ¿Ciencia Ficción o una realidad en el Siglo XXI?” • Now. Tomorrow. Fertility. Definiendo las claves en reproducción asistida. Simposio Merck durante el 31º Congreso Nacional de la Sociedad Española de Fertilidad (SEF); Málaga, Spain; May 2016. “Tomorrowland in Reproductive Medicine”
2015 • IV Jornadas IVI Sevilla. El Futuro en la Reproducción Asistida; Sevilla, Spain; Octubre 2015. “Reproducción Assistida: Presente y Futuro” • X Curso Diatros; Barcelona, Spain; April 2015. “El factor endometrial en la medicina reproductiva” • Gran reunión Nacional Innuva. MSD; Madrid, Spain; February 2015. “¿Qué es la innovación?” 2014 • XXIV Congreso Nacional de la Sección de Medicina Perinatal de la SEGO; Zaragoza, Spain; June 2014. “La resistencia a la dedidualización endometrial mediada por déficit de ANXA2, muestra una causa materna de preeclampsia” 2013 • IV Jornadas de Endocrinología Reproductiva: Abordaje del fallo de Implantación; Madrid, Spain; November 2013. “Abordaje por studio perfil genético endometrio ” 2012 • Controversias en Reproducción, Obstetricia y Ginecología; Valencia, Spain 2012. “Nuevos enfoques al diagnóstico prenatal” 2010 • Forging Partnerships an INTERBIO meeting; Valencia, Spain; January 2010. “Regenerative Medicine” • 7º Congreso Nacional de Enfermería Quirúrgica. “Algo más que cirugía”; Valencia, Spain; March 2010. “Células Madre” • 1ª jornada La sangre del cordón umbilical: fuente de vida; Barcelona, Spain; April 2010. “Conceptos básicos sobre células madre embrionarias, inducidas y adultas” • Simposio satélite. Ómicas, avanzando hacia el futuro de la fertilidad. XXVIII Congreso Nacional de la Sociedad Española de Fertilidad, V Reunión Iberoamericana, III Congreso Nacional de Enfermería de la Reproducción; Valencia, Spain; May 2010. “Como mejorar la implantación embrionaria, nuevas perspectivas” 2009 • Ciclo de conferencias el legado de Prometeo. Científicos Valencianos de Excelencia; Valencia, Spain; April 2009. “Cuando la medicina reproductiva encuentra la medicina regenerativa” • 1er Simposio Internacional en Medicina Regenerativa Traslacional. Fundación Eduardo Anitua; Vitoria, Spain; October 2009. “Potencial de las células madre en medicina regenerativa” 2008 • Ley 14/2007: Un nuevo escenario para la Investigación Biomédica Fundación salud 2000; Madrid, Spain; January 2008. ”Muestras biológicas e investigación con células madre” • Jornadas Asociación Endometriosis España; Valencia, Spain; April 2008. “Investigación”, “¿Qué es la endometriosis” • I Simposio sobre Terapia Celular y Medicina Regenerativa. Centro de Cirugía de Mínima Invasión Jesús Usón; Cáceres, Spain; May 2008. “Células madre embrionarias”
84 • XXVII Congreso Nacional de la Sociedad Española de Fertilidad; Oviedo, Spain; May 2008. “Receptividad endometrial en edad avanzada” • II Jornadas de Medicina Regenerativa. Fundación Investigación regenerativa y salud – Hospital universitario Gregorio Marañón; Madrid, Spain; May 2008. “La excelencia en las técnicas de diagnóstico pre-implantacional como seguro de la viabilidad posterior a la extracción celular del embrión. Su futuro” • Conferencia Ayuntamiento de Sueca; Sueca, Valencia, Spain; June 2008. “Células Madre” • 2028, de qué hablaremos cuando hablemos de salud. XX aniversario de la edición de Viure en Salut, Valencia, Spain; June 2008. “Uso de células madre para desarrollo y aplicación de terapia regeneradora” • 45 congreso nacional de la Sociedad Española de Cirugía Ortopédica y Traumatología; Valencia, Spain; October 2008. “Terapia Celular en Traumatología y Ortopedia” 2007 • Osteoinducción y regeneración ósea, fundamentos, experiencia y perspectivas futuras; Valencia, Spain; February 2007. “Perspectivas futuras” • Producción Científica de la Comunidad Valenciana en materias de Biomedicina y Ciencias de la Salud; Valencia, Spain; March 2007. “Desarrollo de investigación puntera desde una Unidad Mixta” • Foro Sobre Reproducción Humana Asistida, Instituto Europeo de salud y Bienestar Social; Madrid, Spain, March 2007. “I+D+I en Reproducción Humana Asistida” • XLII Congreso Nacional de la Sociedad Española de Cirugía Plástica, Reparadora y Estética; Valencia, Spain; May 2007. “Células madre y cirugía plástica” • IV encuentro del ciclo sobre la medicina del futuro. Grupo Valenciano Capítulo Español del Club de Roma; Valencia, Spain; May 2007. “Presente y futuro de las células madre” • IV Congreso de la Sociedad Española de Terapia Génica y Celular; Madrid, Spain; September 2007. “hESC derivation in feeder-free, xeno-free and embryo-friendly conditions” 2006 • Jornada sobre bioética, Escuela Valenciana de Estudios de la Salud (EVES). Universidad Internacional Menendez Pelayo (UIMP); Valencia, Spain; February 2006. “La investigación con células troncales embrionarias. Aspectos científicos y éticos” • I Curso de actualidad en factor masculino y en técnicas de reproducción asistida. Organizado por IVI Vigo; Vigo, Spain; April 2006. “Células madre para crear gametos” • Ciclo de Conferencias España 2006; Torrelodones, Madrid, Spain; May 2006. “Las células madre embrionarias. Aportación de la medicina reproductiva a la humanidad” • XXVI Congreso nacional de la Sociedad Española de Fertilidad; Zaragoza, Spain; May – June 2006. “Receptividad uterina e implantación” • 55 congreso de la Asociación Española de Pediatría (AEP); Valencia, Spain; June 2006. “Células madre embrionarias como herramienta terapéutica en enfermedades degenerativas” • IX Congreso nacional de la asociación española para el estudio de la menopausia (AEEM) y sección de menopausia de la SEGO; Santiago de Compostela, A Coruña, Spain; June 2006. “Donación de ovocitos en la perimenopausia” • II Jornadas de actualización en investigación oftalmológica. Unidad de Investigación Oftalmológica “Santiago Grisolía”. Hospital Universitario Doctor Peset. Fundación Valenciana de Estudios Avanzados (FVEA); Valencia, Spain; October 2006. “Células madre en Valencia” • X Jornada de enfermos renales. ALCER TURIA; Valencia, Spain; November 2006. “El futuro esperanzador de la investigación con células madre” 2005
85 • Nuevos retos en tecnologías de la salud. Universidad Politécnica de Valencia; Valencia, Spain; February 2005. “Terapias de regeneración” • Los límites de la reproducción humana, CosmoCaixa (Fundación la Caixa); Madrid, Spain; March 2005. “Reproducirnos para curar: las promesas de las células madre” • Hospital General Universitario de Alicante y Centro de Especialidades Babel; Alicante, Spain; March 2005. “Situación actual de los avances en la terapia basada en las células madre en nuestro país” • 5º Curso Diatros, Hormonas y envejecimiento saludable; Barcelona, Spain; April 2005. “Regeneración germinal a partir de células madre” • III Jornadas para médicos residentes sobre reproducción asistida; Bétera, Valencia, Spain. “Células madre. Medicina regenerativa” • XVI Congreso Nacional de la Sociedad Española de Transfusión Sanguínea; San Sebastián, Spain; June 2005. “Células troncales embrionarias: verdades e incertidumbres” • Nuevos conceptos en Ciencias de la Salud y la Vida; Universidad Europea de Madrid; Altea, Alicante, Spain; July 2005. “Investigación con células madre: esperanzas e incertidumbres” • IV Jornadas de Reproducción Humana. Centro Gutemberg; Valencia, Spain; October 2005. “Células madre embrionarias: diferenciación celular y rechazo inmunológico” • Jornadas Sobre Medicina Reproductiva. Hospital Universitario La Fe; Valencia, Spain; November 2005. “Desarrollo de células progenitoras” • 32 Symposium Internacional Fertilidad 2005, Fundación Santiago Dexeus Font; Barcelona, Spain; November 2005. “Derivación de gametos a partir de células madre” • II Congreso Autonómico. Presente y futuro de la discapacidad. Confederación Coordinadora de Discapacitados Físicos de la Comunidad Valenciana. COCEMFE- CV; Valencia, Spain; November 2005. “Estado Actual de las Células Madre Embrionaria en la Medicina Regenerativa” 2004 • XII Reunión Nacional del Grupo Uro-Andrológico de la Asociación Española de Urología; Valencia, Spain; March 2004. “Células madre y reproducción” • II Jornadas sobre reproducción asistida para médicos residentes; Barcelona, Spain; April 2004. “Células madre. Terapia de futuro” • Aula de las provincias; Valencia, Spain; April 2004. “Células madre. Verdades, esperanzas e incertidumbres” • XXV Congreso Nacional de la SEF; A Coruña, Spain; May 2004. “Fallo repetido de implantación: Aspectos clínicos”, “Diagnóstico Genético Preimplantacional dirigido al estudio de enfermedades monogénicas”, “Regeneración germinal a partir de células madre”, “Beca de investigación S.E.F. 2001: El sistema de la leptina durante la receptividad endometrial y el desarrollo preimplantatorio” • I Foro Mundial Valencia en Biotecnología, Universidad de verano Campus TI 2004; Valencia, Spain; July 2004. “Derivación de líneas de células madre embrionarias en España. Obtención células embrionarias” • IX Congreso Nacional de Reales Académias de Medicina de España; Valencia, Spain; October 2004. “Células Madre embrionarias de origen humano” • XXI Congreso de la Asociación de Enfermedades Neuromusculares, Comunidad Valenciana (ASEMCV); Valencia, Spain; November 2004. “Derivación de las dos primeras líneas de células madre embrionarias” • Foro de debate científico, ético y legal a partir de casos clínicos FIV-EXTREME, Conceptum; Reus, Spain; November 2004. “Técnicas de reproducción asistida y diagnóstico pre-implantacional en enfermedades que se manifiestan clínicamente en edad juvenil y adulta. ¿cerramos la puerta?” • Ciclo de conferencias sobre sociedad, salud y derecho en el siglo XXI; Madrid, Spain; November 2004. “Investigación con células madre, esperanzas e incertidumbres”
86 2003 • Metodología de la investigación médica: de los conocimientos básicos a la clínica. (Fundación para la investigación del Hospital Clínico de Valencia); Valencia, Spain; January 2003. “Células madre como futuro de la medicina reparativa” • 4º Curso Diatros. Cuidados en la Salud de la Mujer. De la menarquia a la menopausia; Barcelona, Spain; March 2003. “Técnicas de reproducción asistida y células madre embrionarias” • Presente y futuro de la ataxia, Asociación Ataxias; Fuenlabrada, Madrid, Spain; March 2003. “Células Madre. Utilización de células embrionarias con fines terapéuticos” • XXVII Congreso español de Ginecología y Obstetricia; Santander, Spain; June 2003. “Endometriosis y reproducción asistida” 2002 • 3ª Reunión anual de AVCRA (Asociación vasca de centros de reproducción asistida); Vitoria, Spain; June 2002. “Receptividad endometrial y transferencia embrionaria” • Ética y clonación: Realidades y Exageraciones; Valencia, Spain; January 2002. “El punto de vista de la ciencia” • XI Reunión Científica, Sociedad Vasca de Ginecología y Obstetricia (SVGO). Vitoria, Spain; December 2002. “Investigación en células madre embrionarias, importancia en Biomedicina” 2001 • VII Ginevideo. Certamen Nacional De Vídeo En Obstetricia Y Ginecología; Lugo, Spain; September 2001. “Agonistas y antagonistas en reproducción humana” • Últimas novedades en el tratamiento de la infertilidad; Madrid, Spain; November 2001. “Diagnóstico preimplantatorio” 2000 • XXIII Congreso Nacional de la Sociedad Española de Fertilidad; Seville, Spain; May 2000. “Influencia de las anomalías cromosómicas en el desarrollo preimplantatorio de embriones humanos”, “Control de la Implantación: Posibilidades” • Jornadas sobre infertilidad; Valencia, Spain; November 2000. “Últimos avances clínicos en la mejora de la implantación embrionaria” 1999 • Medicina molecular: genética molecular, inflamación e infertilidad. I Jornada LXXV Aniversario; Madrid, Spain; March 1999. “Aspectos básicos y clínicos de la implantación del embrión humano” • II Jornadas Sobre Reproducción Asistida; Córdoba, Spain; May 1999. “Conocimiento actual del proceso de implantación” ••• XXV Congreso Nacional de Ginecología; Zaragoza, Spain; June 1999. “Nuevos conceptos de la implantación” • II Congreso ibérico de Reproducción animal; Lugo, Spain; July 1999. “Inseminación intracitoplásmica, ICSI” • Jornadas sobre infertilidad 1999; Madrid, Spain; October 1999. “Nuevas indicaciones y actualizaciones” 1998 • Symposium sobre reproducción humana; Elche, Alicante, Spain; November 1998. “Implantación embrionaria” 1997 • Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana; Alicante, Spain; January 1997. “Aborto de Repetición. Implantación Embrionaria” . • Curso sobre Inseminación Artificial y Fertilización in Vitro; Madrid, Spain; March 1997. “Factores Pronósticos de la Implantación” • XX Aniversario del Hospital Ramon y Cajal; Madrid, Spain; October 1997. “Cocultivos: Evaluación de criterios de actuación” • Jornada sobre infertilidad en la pareja. Universidad Internacional Menéndez Pelayo;
87 Valencia, Spain; October 1997. “Cocultivo embrionario” 1996 • XXI Congreso Nacional de la Sociedad Española de Fertilidad. Tenerife, Spain; June 1996. “Fisiología de la implantación” 1995 • III Simposio sobre reproducción humana, Temas actuales en reproducción asistida. Hospital Ramón y Cajal; Madrid, Spain; January 1995. “Ventana de implantación” 1994 • XX Congreso Nacional de la Sociedad Española de Fertilidad; Valencia, Spain; May 1994. “Implantación”. • I Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana; Valencia, Spain; October 1994. “Uso de las gonadotrofinas en la estimulación ovárica”
88 Undergraduate & Scientific Fellows. PhDs Postgraduate 2016 – present David Bolumar, ‘Study and characterization of different secreted vesicles Teaching, from the endometrium to endometrial fluid’. Past & Present Students 2016 – present Iolanda García, ‘Analysis of endometrial microbiome and its relation with endometrial receptivity in infertile patients’. 2016 – present Laura Rubert, ‘Deficit of annexin-2 as maternal cause of severe and early preeclampsia and possible predictor’. 2015 – present Stefania Salsano, ‘Expression, localization and functional study of protein PGRMC1 (Progesterone Receptor Membrane Component 1) in human endometrium’ 2015 – present Silvia Pérez, ‘Endometrial proteomic in implantation failure’. 2015 – present Hannes Campo, ‘Advanced theraphies and biotechnology innovation in reproductive health’. 2015 – present Nuria López, ‘Specific markers in somatic endometrial stem cells’. 2014 – 2017 Jose Manuel Míguez, ‘Direct reprograming from somatic to human germ cells’ 2014 – present Nuria Balaguer, ‘Determination of the differential expression of miRNAs in endometrial fluid as the presence of obesity and type 2 diabetes in women’. 2014 – present Alessia Grasso, ‘Analysis of specific miRNAs in human endometrial fluid for use as a non-invasive diagnosis of endometrial receptivity’. 2012 – 2016 Gemma Castillón, ‘Prospective and randomized study about the utility of HCG Array in embryonic aneuploidies in servere male factor’. Co- supervisor with Dr. Carmen Rubio and Inmaculada Sánchez. 2012 – 2016 Sevkiye Tudge Pehlivan Budak, ‘New therapeutic possibilities in implantation failure’. Co-supervisor with Dr. Carmen Rubio. 2011 – 2015 Pablo Padilla, ‘Decidualization pattern in women with preeclampsia applying Proteomics and Transcriptomic methods’. Co-supervisor with Dr. Alfredo Perales 2010 – 2014 Ana Martínez-Arroyo, ‘Direct reprogramming for Adult Somatic Cells to Meiotic Germinal Cells’. Co-supervisor with Dr. Jose Vicente Medrano. 2010 – 2014 Juan Manuel Moreno Moya, ‘miRNAs analysis in endometrial fluid as non- invasive method of endometrial receptivity’. Co-supervisor with Dr. Felipe Vilella. 2010 – 2014 Leslie Ramírez Lima, ‘A non-invasive diagnosis method of human endometrial receptivity status based on a specific lipidomic profiling in the endometrial fluid’. Co-supervisor with Dr. Felipe Vilella. European PhD. 2010 – 2014 Lorena Rodrigo Vivó, ‘Value of sperm chromosome studies using the technique of fluorescent in situ hybridization (FISH) in infertile couples’. Co-supervisor with Dr. Manuel Gil-Salom and Dr. Carmen Rubio 2009 – 2013 Claudia Gil Sanchis, ‘Identification, characterization and isolation of somatic stem cells in the human endometrium’. Co-supervisor with Dr. Irene Cervelló. European PhD. 2009 – 2013 Inmaculada Sánchez Ribas, ‘Metabolomic profiling of human pre- embryos as potential marker for noninvasive aneuploidy’. Co-supervisor with Dr. Francisco Domínguez. Co-supervisor with Dr. Francisco Domínguez and Dr. Agustín Ballesteros. 2008 – 2013 Marcia Riboldi, ‘ Isolation, culture, characterization and maturation of undifferentiated cells from human testicular biopsies’. 2009 – 2012 Isabel Herrer Mambrona, ‘Epigenetic mechanisms in endometrial stromal
89 cells during the process of decidualization” Co-supervisor with Dr. Carlos Estella 2009 – 2012 Manuel Fernández Sánchez, ‘Endometrial study of a novel in vivo embryo culture’. European PhD. Co-supervisor with Dr. Antonio Pellicer and Dr. José Antonio Horcajadas. 2008 – 2012 Aymara Más Perucho, ‘Identification, characterization and isolation of somatic stem cells in humans myomas’. Co-supervisor with Dr. Irene Cervelló 2008 – 2012 Tamara Gómez Garrido, ‘Proteomic study of the human endometrium’. Co-supervisor with Dr. Francisco Domínguez. 2008 – 2012 Jose Vicente Medrano Plaza. ‘Meiotic induction in vitro derived germ cells obtained from human pluripotent stem cells by ectopic expression of the RNA binding proteins DAZL and VASA’. 2007 – 2011 Patricia Díaz Gimeno, ‘Developing a molecular diagnostic tool for the endometrial receptivity’. Co-supervisor with Dr. Jose Antonio Horcajadas. 2004 – 2008 Irene Cervello Alcaraz, ‘Identification, characterization and isolation of somatic stem cells of the murine and human endometrium’ 2003 – 2006 Ana Cristina Cerveró Sanz. ‘The leptin system in the maternal-embryonic interface: impact in the implantation’ 2001 – 2005 Mª Carmen Escobedo Lucea, ‘First derivation in Spain of two lines of human embryonic stem cells with therapeutic grade, VAL-1 and VAL-2’. Co-supervisor with Dr. Antonio Pellicer 2001 – 2005 Julia Desco Blay, ‘Contribution of preimplantation genetic diagnosis to the origin of early pregnancy loss’. Co-supervisor with Dr. Antonio Pellicer 2001 – 2004 Raúl Gómez Gallego, ‘Blocking VEGFR-2 as a key mechanism for the inhibition of vascular permeability in Ovarian Hyperstimulation Syndrome’. Co-supervisor with Dr. Antonio Pellicer 2001 – 2004 Carmen Rubio Lluesa, ‘Study of the Chromosomal abnormalities in embryos and sperm in couples with recurrent miscarriage and unexplained causes’. Co-supervisor with Dr. Francesca Vidal 2001 – 2004 Amparo Mercader Bayarri. ‘Embryo coculture with human endometrial epithelial cells as a technique for implantation failure’. Co-supervisor with Dr. Antonio Pellicer 2000 – 2003 Diana Valbuena Perilla.’ Effects of high serum estradiol levels on embryo implantation in patients undergoing in vitro fertilization’. Co-supervisor with Dr. José Remohí. 2000 – 2003 Francisco Domínguez Hernández. ‘Implication of IL-8, MCP^-1, RANTES, chemokines, CXR1, CXCR4, CCR2, CCR5 receptors and IGFBP-rP1 factor in the maternal-embryonic interface’. Co-supervisor with Dr. Antonio Pellicer 1999 – 2003 Arancha Galán Rivas, ‘Embryonic regulation of the apoptosis in the human endometrial epithelium’. Co-supervisor with Dr. Antonio Pellicer 1999 – 2002 Manuel Rodríguez González, ‘Predictive mathematical method of the gestational and implantation rate in an IVF particular cycle, depending on the age of the patient, number of previous attempts, embryo quality and number of previous attempts, embryo quality and number of embryos transferred’. Dr. José Remohí and Dr. Amparo Ruiz 1999 – 2001 Marcos Meseguer Escrivá, ‘Hormonal and embryonic regulation of human mucin MUC1 in endometrial epithelium’. European PhD. 1998 – 2001 Nicolas Garrido Puchalt, ‘Alterations in folliculogenesis as cause of the low oocyte quality in patients with endometriosis; In vivo and in vitro studies of the granulosa cells and follicular leukocytes’. Co-supervisor
90 with Dr. Antonio Pellicer 1998 – 2001 Carmela Albert Rodríguez, ‘Pathophysiology of ovarian hyperstimulation syndrome: implicaton of the endothelium’. Co-supervisor with Dr. Antonio Pellicer. 1997 – 2000 Pedro Caballero Campo, ‘Hormonal and embryonic regulation in human endometrial chemokines: Interleukin-8 (IL-8), Quimiotrayente Monocyte Protein-1 (MCP-1) and Regulated upon Activation, Normal T Expressed and Secreted (RANTES)’. Co-supervisor with Dr. Antonio Pellicer 1996 – 1999 Mª José Gimeno Almela, ’Embryonic regulation of the integrins in the human endometrial epithelium’. Co-supervisor with Dr. Julio Coloma. 1991 – 1995 Mª José de los Santos Molina, ‘Immunohistochemical localization and regulatory endometrial factors of the interleukin-1 secretion during preimplantation development of the human embryo’. Co-supervisor with Dr. Antonio Pellicer.
Clinical Fellows. MDs 2015 – Present Dra. Nora Katzorke (Germany) 2013 – Present Dr. Sergio Cabanillas (Argentina). 2013 – Present Dr. Albeiro Muñoz (Colombia). 2013 – Present Dr. Miguel Ramírez (Mexico). 2012 – Present Dr. Gilberto Ibérico (Lima). 2012 – Present Dr. Bruno Araujo (Brazil). 2012 – Present Dr. Alejandro Rivas (Peru). 2011 – 2013 Dra. Adriana Landazábal (Colombia). 2011 – 2013 Dr. Felipe Camargo (Colombia). 2011 – 2013 Dra. Gabriela Villaquiran (Colombia). 2010 – 2012 Dr. Juan Vargas (Chile). 2010 – 2012 Dr. Marcos Cuneo (Mexico). 2010 – 2012 Dr. Fernando Gonzalez (Guatemala). 2009 – 2011 Dra. Cinzia Caligara (Italy). 2009 – 2011 Dr. Antonio Romero (Mexico). 2009 – 2011 Dr. Claudio Álvarez (Chile). 2008 – 2010 Dr. Ismael Gutierrez (Peru). 2008 – 2010 Dra. Isabel Isaza (Colombia). 2008 – 2010 Dr. Rafael Freire (Venezuela). 2007 – 2009 Dr. Bruno Sheffer (Brazil). 2007 – 2009 Dr. Roberto Friche (Brazil). 2007 – 2009 Dr. Cristiano Busso (Brazil). 2006 – 2008 Dr. Ernesto Escudero (Peru). 2006 – 2008 Dra. Mercedes Molina (Lima). 2006 – 2008 Dr. Alberto Guanes (Paraguay). 2005 – 2007 Dr. Norberto Rossal (Guatemala). 2005 – 2007 Dr. Elkin Muñoz (Colombia). 2005 – 2007 Dr. Alberto Levy (Venezuela). 2004 – 2006 Dra. Camila Sagástegui (Peru). 2004 – 2006 Dr. Carlos Gaytán (Mexico). 2004 – 2006 Dra. Elsa Yalil (Paraguay).
91 2003 – 2005 Dra. Eugenia Maquera (Argentina). 2003 – 2005 Dr. Alonso Martín (Mexico). 2002 – 2004 Dr. Carlos Troncoso (Chile). 2002 – 2004 Dra. Claudia Barrientos (Peru). 2002 – 2004 Dr. Juan José Gallardo (Mexico). 2001 – 2003 Dr. Ismael Garza (Mexico). 2001 – 2003 Dr. Gustavo Meléndez (Guatemala). 2000 – 2002 Dr. Carlos Zúñiga (Colombia). 2000 – 2002 Dr. Pablo Tabeo (Venezuela). 1999 – 2001 Dr. Juan Ruiz (Spain). 1999 – 2001 Dr. John Anyakora (USA). 1998 – 2000 Dra. Juana Fernández (Uruguay). 1998 – 2000 Dr. Antonio Díaz (Mexico). 1997 – 1999 Dra. Diana Valbuena (Colombia). 1997 – 1999 Dr. Roberto Epifanio (Panama). 1996 – 1998 Dr. Juan Manuel Moreno (Panama). 1996 – 1998 Dr. Ignacio Paredes (Venezuela). 1996 – 1998 Dr. Juan Felipe Valdes (Mexico). 1995 – 1997 Dr. Julián Villalobos (Venezuela). 1995 – 1997 Dr. Claudio Scheffer (Brazil). 1995 – 1997 Dra. Daniela Gerulewicz (Venezuela). 1994 – 1996 Dr. Juan Carlos Cano (Colombia). 1994 – 1996 Dra. Clara Isabel Gaytan (Colombia). 1994 – 1996 Dr. Felipe Gutierrez (Mexico). Conference 2016 Meeting Organizer, 3rd Biomarker meeting in Reproductive Medicine: Organization Personalized Reproductive Medicine. April 7 – 9. Valencia, Spain. 2014 Meeting Chairperson Organizer, 2 nd Biomarker meeting in Reproductive Medicine: Personalized Reproductive Medicine. March 19 – 22. Valencia, Spain. 2013 Scientific Organiser, The Top ten in reproductive medicine: debating breathrough basic and clinical papers with their authors. Serono Symposia International Foundation. September 20 – 21. Florence, Italy. 2012 Meeting Chairperson Organizer, 1 st Biomarker meeting in Reproductive Medicine: Emergence of a New Field. March 30 – 31. 2012. Valencia, Spain. 2007 Chairman, 2nd Summit of the Society for Gynecologic Investigation on Reproductive Medicine. November 8-10, 2007. Valencia, Spain. 2006 Scientific Organiser, Therapeutic Potencial of Stem Cells in Reproductive Medicine. Serono Symposia International Foundation. March 31 – April 1, 2006. Valencia, Spain. 2005 Organizer, International Symposium on Reproductive Medicine. Cátedra Santiago Grisolía. October 27 – 28, 2005. Valencia, Spain. 2003 Secretary of the Local Organising Committee, 19th Annual Meeting, European Society of Human Reproduction and Embrylogy (ESHRE). June 29 – July 2. Madrid, Spain. 2003 Scientific Organiser, III Human Implantation Workshop. Serono Foundation. June 28, 2003. Madrid, Spain. 2001 Scientific Organiser, II International Workshop on Human Implantation. May 4-5, 2001. Madrid, Spain. 2000 Scientific Advisory Committee, Reproductive competence: Pathophysiology and Therapeutic Interventions. November 28-30, 2000. Santiago de Chile, Chile.
92 1999 Scientific Organiser, I International Workshop on Human Implantation: Recent Advances & Clinical Aspects. Ares Serono Foundation. March 22- 23, 1999. Valencia, Spain. 1998 Organiser, Ovarian Hyperstimulation Syndrome (OHSS), European Society of Human Reproduction and Embrylogy (ESHRE) Campus 98. December 4-5, 1998. Valencia, Spain. 1998 Organiser, State of the ART of Human Implantation, Basic and Clinical Aspects, International Symposium on Reproductive Medicine, Co- Sponsored by ASRM – ESHRE – IVI. May 18-19, 1998. Madrid, Spain. 1996 Scientific Organiser, El Mundo en el Siglo XXI: Crear la vida. Universidad de Valencia. February-May, 1996. Valencia, Spain. 1995 Scientific Organiser, V international Symposium of the IVI, New technologies applied to research in reproduction and ESHRE Symposium on Reproductive Medicine “Maternal-Embryo Interactions. March 9-11, 1995. Valencia (Spain).
93 Conference Internationals presentations & 2017 abstracts • Nuria Balaguer, Inmaculada Moreno, María Herrero, Marta González-Montfort, Carlos Simón, Felipe Vilella. Maternal MiR-30d Deficiency Is Associated with Defects in Endometrial Receptivity, Embryonic Implantation and Fetal Development. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Oral Presentation. • Stefania Salsano, Alicia Quiñonero, Silvia Pérez, Carlos Simón, Francisco Domínguez. Non-Classical Progesterone Receptor (PGRMC1) and SERPINE1 mRNA Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Oral Presentation. • Inmaculada Moreno, Iolanda Garcia-Grau, Angela Silva, Felipe Vilella, Diana Valbuena, Daniel Ramon, Carlos Simon. In Vitro Model of Bacterial Colonization for the Study of the Effect of the Endometrial Microbiota on the Reproductive Function. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Oral Presentation. • Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quiñonero, Patricia Diaz- Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla, Olga Genbacev, Alfredo Perales, Susan J Fisher, Carlos Simon. Severe Preeclampsia Is Associated with Resistance to Decidualization. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Oral Presentation. • Patricia Sebastian-Leon, Ana Conesa, Vicente Arnau, Jose Remohí, Antonio Pellicer, Carlos Simon, Patricia Diaz-Gimeno. Network Biology of Menstrual Cycle to Understand the Key Drivers of Endometrial Receptivity. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Poster Presentation. • Patricia Diaz-Gimeno, María Ruiz-Alonso, Patricia Sebastián-León, Vineeta Singh, Antonio Pellicer, Diana Valbuena, Carlos Simón. Improvement of the Endometrial Receptivity Signature Reveals a Possible Maternal Origin of Biochemical Pregnancies. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Poster Presentation. • Meera S Shah, Felipe Vilella, Barry Behr, Vikrant Reddy, Wanxin Wang, Roserr Navarro, Jorge Jimenez, Steven Quake, Carlos Simon. Maternal Endometrial hsa- miR-30d Is Taken Up by the Human Blastocyst and Induces Transcriptional Modifications. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Poster Presentation. • David Bolumar, Inmaculada Moreno, María Herrero, Sergio Cabanillas, Felipe Vilella, Carlos Simon. Extracellular Vesicles Secreted by the Human Endometrium Contain Specific DNA Sequences That Are Uptaken by Murine Embryos. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Poster Presentation. • Nuria López-Pérez, Claudia Gil-Sanchis, Amparo Faus, Ana Díaz, Hannes Campo, Antonio Pellicer, Irene Cervelló, Carlos Simón. Human Endometrial Reconstitution Using W5C5+, ICAM1+ Cells andSide Population Cell Lines in a Xenograft Model. 63rd Annual Meeting of the Society for Reproductive Investigation. March 2017; Orlando, FL, USA. Poster Presentation. • Rajni Khajuria, Lorena Rodrigo, Diana Valbuena, Carmen Rubio, Carlos Simon. Incidence of chromosomal aneuploidies at embryonic level with comparison based on type of biopsy and maternal age: First Indian experience. 16th International Symposium on Preimplantation Genetics organized by the Preimplantation Genetic Diagnosis International Society. March 2017; Valencia, Spain. Poster Presentation. • Mateu, Emilia; Rodrigo, Lorena; Peinado, Vanesa; Milán, Miguel; Campos, Inmaculada; García-Herrero, Sandra; Mercader, Amparo; Bronet, Fernando; Larreategui, Zaloa; Florensa, Mireia; Remohí, José; Pellicer, Antonio; Simón, Carlos; Rubio, Carmen. Preimplantation Genetic Diagnosis for translocations and interchromosomal effect assessed by array CGH. 16th International Symposium on
94 Preimplantation Genetics organized by the Preimplantation Genetic Diagnosis International Society. March 2017; Valencia, Spain. Poster Presentation. • Bruno Coprerski, Mariane Souza, Carmen Rubio, Carlos Simon, Marcia Riboldi. Does the change of technology from ACGH to NGS impact aneuploidy rates? 16th International Symposium on Preimplantation Genetics organized by the Preimplantation Genetic Diagnosis International Society. March 2017; Valencia, Spain. Poster Presentation. • S. Garcia_Herrero, J. Ferro, I. Campos-Galindo, E. Mateu, M. Milán, V. Peinado, L. Rodrigo, C. Rubio, C. Simón. Feto-Placental discrepancies in the analysis of products of conception in clinical miscarriages reveals that mosaicism is not restricted to trophoblast cells. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Oral Presentation. • M. Vera-Rodriguez, A. Diez-Juan, S. Martinez, V. Peinado, A. Mercader, I. Moreno, D. Valbuena, D. Blesa, C. Simon, C. Rubio. Non-Invasive PGS reveals the existence of complementary aneuploidy between DNA obtained from trophectoderm biopsy versus DNA in spent culture medium in the same embryo. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Oral Presentation. • I. Garcia-Grau, E. Cicinelli, M. Gonzalez-Monfort, F. Vilella, D. Valbuena, C. Simon, I. Moreno. Sensibility and specificity of the molecular vs classical diagnosis of chronic endometritis. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • Alessia Grasso, Roser Navarro, Inmaculada Moreno, María Herrero, Pilar Alama, Felipe Vilella, Carlos Simón. Differential microRNA profile in the endometrial fluid (EF) in natural cycles, HRT, and controlled ovarian stimulation (COS) triggered with hCG (COS+hCG) or GnRHa (COS+GnRHa). 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • J. Miravet, M. Ruiz-Alonso, S. Taguchi, M. Clemente, M. Funabiki, E. Gomez, C. Marin, Y. Nakamura, C. Simon. Endometrial injury does not affect the endometrial transcriptomic profile during the window of implantation. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • K. Krjutškov , A. Reddy , M. Saare , S. Katayama , L. Kumar , K. Gemzell Danielsson , F. Lanner , E. Einarsdottir , D. Blesa , C. Simon , J. Kere , A. Salumets , S. Altmäe. Interactome between embryo trophectoderm cells and endometrial epithelial and stromal cells: novel insights into implantation process in human. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • M. Suhorutshenko , V. Kukushkina , A. Velthut-Meikas , R. Mägi , M. Peters , S. Altmäe , K. Krjutškov , J. Martinez-Blanch , F. Codoñer , F. Vilella , C. Simon , A. Salumets . Novel endometrial receptivity markers detected in large-scale RNA- sequencing study combining samples from different populations. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • A. Liñán Tegedor, A. Bayram, A. Arnanz, C. Rubio, R. Chopra, I. Elkhatib, C. Simón, H. Fatemi. Concordance rates between single blastomere day-3 (D3) and trophectoderm biopsies (D5) using Next Generation Sequencing (NGS). 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Poster Presentation. • S. Herraiz, M. Romeu, S. Martínez, P. Solves, I. Gómez, J. Martínez, A. Buigues, D. Galliano, C. Simón, C. Díaz-García, A. Pellicer. Two live birth after Stem cell ovarian auto-transplantation in Poor Responder women. 33nd Annual Meeting of European Society for Human Reproduction and Embryology. July 2017; Geneva, Switzerland. Oral Presentation. 2016
95 • Rodrigues FP, Bonetti TC, Carvalho CV, Vigo F, Fraietta R, Vilella F, Simon C, Motta E. miRNA expression in receptive versus post-receptive endometrium in patients undergoing IVF. 72nd Scientific Congress of the American Society for Reproductive Medicine (ASRM) October 2016; Salt Lake City, Utah, USA. Poster Presentation. • Medrano JV, Miguez JM, Moreno I, Simon C. Special research presentation: direct conversion of human somatic cells to induced germ-like cells by genetic reprogramming. 72nd Scientific Congress of the American Society for Reproductive Medicine (ASRM) October 2016; Salt Lake City, Utah, USA. Oral Presentation. ••• Simon C, Vladimirov IK, Castillon Cortes G, Ortega I, Cabanillas S, Vidal C, Giles J, Izquierdo A, Portela S, Fernandez I, Ferrando M, Mackens S, Barrera A, Pellicer A. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh trasnfer or deferred embryo transfer. 72nd Scientific Congress of the American Society for Reproductive Medicine (ASRM) October 2016; Salt Lake City, Utah, USA. Oral Presentation. SREI PRIZE PAPER • Rubio C, Campos-Galindo I, Rivera Egea R, Garrido N, Simón C, Domínguez F. Effect of environmental endocrine disruptor’s exposure on sperm quality and aneuploidy rates in fertile sperm donors. 72nd Scientific Congress of the American Society for Reproductive Medicine (ASRM) October 2016; Salt Lake City, Utah, USA. Oral Presentation. • Bolumar D, Moreno I, Cabanillas S, Simon C, Vilella F. Isolation and identification of extracellular vesicles in the human endometrial fluid. 72nd Scientific Congress of the American Society for Reproductive Medicine (ASRM) October 2016; Salt Lake City, Utah, USA. Oral Presentation. • Dominguez F, Campos-Galindo I, Alama P, Romero JL Simon C, Rubio C. Impact of environmental endocrine disruptor’s expsure in controlled ovarian stimulation outcome in egg donors. 32nd Annual Meeting of European Society for Human Reproduction and Embryology (ESHRE). July 2016; Helsinki, Finland. Oral Presentation. • Valbuena-Perilla D, Ruiz-Alonso M, Marin C, Soria J, Simon C, Garcia-Velasco JA. Endometrial thickness does not predict endometrial receptivity. 32nd Annual Meeting of European Society for Human Reproduction and Embryology (ESHRE). July 2016; Helsinki, Finland. Poster Presentation. • Cerillo-Martinez M, Ruiz M, Bermejo A, Blesa D, Mayoral M, Garcia-Velasco JA, Simon C. The window of endometrial receptivity might be displaced under different protocols for endometrial preparation. 32nd Annual Meeting of European Society for Human Reproduction and Embryology (ESHRE). July 2016; Helsinki, Finland. Poster Presentation. • Altmäe S, Võsa U, Suhorutsenko M, Aghajanova L, Adler P, Giudice L, Simon C, Salumets. Meta-analysis of endometrial receptivity-associated genes. 32nd Annual Meeting of European Society for Human Reproduction and Embryology (ESHRE). July 2016; Helsinki, Finland. Poster Presentation. • Simon B, Moreno I, Bolumar D, Vilella F, Simón C. Trophoectoderm Cells of Embryos Secrete Extracellular Vesicles to the Conditioned Media. 63rd Annual Scientific Meeting of the Society for Reproductive Investigation (SRI). March 2016; Montreal, Canada. Oral Presentation. Pfizer-SRI President's Presenter's Award • Balaguer N, Moreno I, Herrero M, Simón C, Vilella F. Maternal Endometrial hsa-miR- 30d Is Internalized and Secreted in Exosomes by Binding with hnRNPC1. 63rd Annual Scientific Meeting of the Society for Reproductive Investigation (SRI). March 2016; Montreal, Canada. Oral Presentation. Pfizer-SRI President's Presenter's Award • Perez-Deben S, Bellver J, Alama P, Salsano S, Quiñonero A, Simón C , Domínguez F. iTraq Proteomic Comparative Analysis of Endometrium from Fertile Donors, IUD Carriers and Patients with Recurrent Implantation Failure (RIF) Reveals No Differential Proteomic Profile in RIF versus Fertile Donors. 63rd Annual Scientific Meeting of the Society for Reproductive Investigation (SRI). March 2016; Montreal,
96 Canada. Poster Presentation. • Campo H, Baptista P, Lopez-Perez Nuria, Faus A, Cervelló I, Simón C . De- and Recellularization of the Pig Uterus: A Pilot Study in Uterus Bioengineering. 63rd Annual Scientific Meeting of the Society for Reproductive Investigation (SRI). March 2016; Montreal, Canada. Poster Presentation. • Mas A, Prusinski L, Yang Q, Elam L, Diamond MP, Simón C , Al-Hendy A. Role of Stro1(+)/CD44(+) Myometrial Stem Cells in Pregnancy-Induced Uterine Remodeling. 63rd Annual Scientific Meeting of the Society for Reproductive Investigation (SRI). March 2016; Montreal, Canada. Poster Presentation. • García-Herrero S, Campos-Galindo I, Mateu I, Milán M, Peinado V, Ferro J, Rodrigo L, Simón C , Rubio C. Molecular analysis of fetoplacental discrepancies in Products of Conception (POCS) obtained by hysteroembryoscopy. Third Annual Advances in Prenatal Molecular Diagnostics. Trends, Advances & Prospects. April 2016; Lisbon. Poster Presentation. 2015 • Milan M, Mateu E, López P, Blesa D, Diez A, Rubio C, Simón C . Non-invasive prenatal testing using massively parallel sequencing. First experience in Spain. Third Annual Advances in Prenatal Molecular Diagnostics. November 2015; Boston, USA. Poster Presentation. • Milan M, Rodrigo L, Peinado V, Campos I, García S, Vera M, Simón C, Rubio C. Preimplantation genetic screening on the stage at which biopsies are performed. Reproductive Geentic Diagnostics. November 2015; Boston, USA. Poster Presentation. • Mas A, Elam L, Wlaker C, Simón C , Diamond MP, Thompson W, Al-Hendy A. Early life exposure to estrogen-mimics increase the occurrence of uterine fibroids via expansion of myometrial stem cell population. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Oral Presentation. • Rubio C, Rodrigo L, Bellver J, Castillon G, Guillen A, Vidal C, Giles J, Simón C . Improved clinical outcome in women between 38 and 41 years of age by 24- chromosome aneuploidy screening. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Oral Presentation. • Mas A, Elam L, Diamond MP, Simón C . Synergistic effect of estrogen and progesterone on myometrial stem cell expansion in vivo. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Oral Presentation. • Santamaria X, Cabanillas S, Arbona C, Simón C . Autologous cell therapy with CD133+ bone marrow stem cells in refractory Asherman’s Syndrome and edometrial atrophy: a pilot cohort study. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Oral Presentation. • Martin J, Rodriguez-Iglesias B, San A, Yuting Y, Jimenez J, Li Q, Du H, Simón C . Development, validation and clinical use of and expanded pan-ethnic preconception carrier genetic screening test in assited reproductive technology patients and donors. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Poster Presentation. • Rubio C, Marin C, Martinez S, Diaz-Gimeno P, Riboldi M, Al-Asmar N, Valbuena D, Simón C . Mitochondrial DNA content as a viability score in human euploid embryos: less is better. 71st Annual Meeting of the American Society for Reproductive Medicine. October 2015; Baltimore, MD, USA. Poster Presentation. • Mateu E, Rodrigo L, Peinado V, Milán M, Campos-Galindo I, García-Herrero S, Simón C , Rubio C. Sperm concentration and inter-chromosomal effect in male carriers of Robertsonian translocations. 1st Meeting on Controversies in preconception, preimplantation and prenatal genetic diagnosis: How will genetics technology drive the future? Controversies in preconception, preimplantation and prenatal genetic diagnosis (CoGEN): How will genetics technology drive the future?. September 2015; Paris, France; Poster Presentation. • Martinez-Conejero JA, Al-Asmar N, García-Herrero S, Campos-Galindo I, Akinwole A,
97 Cinnioglu C, Simon C, Rubio C. Increasing aneuploidy detection in Products of Conception (POC) by molecular analysis and multisdissection of fetal tissue. Controversies in preconception, preimplantation and prenatal genetic diagnosis (CoGEN): How will genetics technology drive the future?. September 2015; Paris, France; Poster Presentation. • Navarro-Gaya R, Conesa A, Ruíz-Alonso M, Simón C , Díaz-Gimeno P. Looking for biological functionality In gene set networks. Smodia 2015, Statistical methods for omics data integration and analysis. September 2015; Valencia, Spain. Poster Presentation. • Peinado V, Al-Asmar N, Alegre L, Vera M, Rodrigo L, Martínez-Jabaloyas JM, Gil- Salom M, Remohí J, Simón C , Hassold T, Rubio C. Increased risk of sperm chromosomal abnormalities and decreased recombination frequency in non- obstructive azoospermic males . 31st Annual Meeting of the European Society for Human Reproduction and Embryology. June 2015; Lisbon, Portugal. Oral Presentation. • Riboldi M, Poo ME, Coprerski B, Santos M, Bandeira CL, Al-Asmar Piñar N, Rodrigo L, Simón C , Rubio C. Decrease to complex aneuploidies during embryo development from day-3 to blastocyst stage. 31st Annual Meeting of the European Society for Human Reproduction and Embryology. June 2015; Lisbon, Portugal. Poster Presentation. • Rubio C, Rodrigo L, Florensa M, Mateu E, Mercader A, Peinado V, Bronet F, Milan M, Garcia-Herrero S, Campos-Galindo I, Simón C . Differences in chromosomal abnormalities observed in preimplantation embryos according to male or female meiosis disruption in isolated male factor (MF) and advanced maternal age (AMA). 31st Annual Meeting of the European Society for Human Reproduction and Embryology. June 2015; Lisbon, Portugal. Poster Presentation. • Mir Pardo P, Mateu E, Mercader A, Herer R, Rodrigo L, Vera M, Peinado V, Milán- Sánchez M, Campos-Galindo I, García-Herrero S, Simón C , Rubio C. Are false positive rates comparable at day-3 blastomere versus day-5 trophectoderm biopsies using array cgh for preimplantation genetic screening?. 31st Annual Meeting of the European Society for Human Reproduction and Embryology. June 2015; Lisbon, Portugal. Poster Presentation. • Meseguer M, Dominguez F, Tejera A, Quiñonero A, Aparicio-Ruiz B, Simón C . A new strategy to diagnose embryo viability combining protearray and time-lapse technologies. 31st Annual Meeting of the European Society for Human Reproduction and Embryology. June 2015; Lisbon, Portugal. Poster Presentation. • Rodrigo L, Mateu E, Peinado V, Milán M, García-Herrero S, Campos-Galindo I, Vera M, Mercader A, Bronet F, Simón C , Rubio C. Why preimplantation genetic Screening (PGS) improves clinical outcome in couples with low sperm counts? Impact of spermaneuploidy. 14 th International Conference of Preimplantation Genetic Diagnosis, A Quarter Century of PGD. May 2015; Chicago, Illinois, USA. Oral Presentation. • Cervero A, Martínez-Conejero JA, Mir P, Rodrigo L, Rubio C, Al Asmar N, Kayali R, Cinnioglu C Simón C , Martín J. Clinical outcome of preimplantation genetic diagnosis for single-gene disorders could be improved with simultaneous comprehensive chromosome screening. 14 th International Conference of Preimplantation Genetic Diagnosis, A Quarter Century of PGD. May 2015; Chicago, Illinois, USA. Oral Presentation. • Altmäe S, Tamm-Rosenstein K, Esteban FJ, Martinez-Conejero JA, Simm J, Ruiz- Alonso M, Metsis M, Simón C, Horcajadas JA, Salumets A, Stavreus-Evers A. Endometrial gene expression analysis in natural cycle vs. hormonally replaced cycle for frozen embryo transfere in patients with recurrent implantation failulre. April 2015; Alicante, Spain. Poster Presentation. • García-Herrero S, Campos-Galindo I, Mateu E, Milán M, Peinado V, Rodrigo L, Ferro J, Rubio C, Simón C . Case report of confined placental mosaicism after preimplantation genètic screening (PGS) by comparative genòmic hybridization arrays (aCGH). April 2015; Alicante, Spain. Poster Presentation.
98 • Mas A, Nair S, Laknaur A, Eroglu A, Diamond MP, Simón C , Al-Hendy A. Establishment of stro1/CD44 as new markers for human myometrial/fibroid stem cells. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Poster Presentation • Mas A, Laknaur A, O’Connor PM, Walker CL, Diamond MP, Simón C , Al-Hendy A. Myometrial tumor-forming stem cells in a murine model of uterine fibroids reside in hypoxic niches. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Poster Presentation • Cervelló I, Santamaria X, Gil-Sanchís C, Faus A, Cabanillas S, Simón C . Human bone marrow-derived stem cells improve endometrial regeneration in a murine experimental Asherman’s Syndrome. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Poster Presentation. • Salsano S, Quiñonero A, Garrido T, Simón C , Domínguez F. Progesterone receptor membrane component 1 (PGRMC1) localization in human endometrial stromal cells (hESC) and its impact of decidualization. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Poster Presentation. • Moreno I, Vilella F, Martínez JF, Codoñer FM, Ramón D, Simón C . Impact of the endometrial microbiome on uterine receptivity and pregnancy outcome. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Poster Presentation. • Balaguer N, Vilella F, Moreno JM, Herrero M, Simón C . Hsa-miR-30d is transported by exosomes from human endometrial epithelium to the trophectoderm of preimplantation embryos and modulates embryo adhesion. 62nd Annual Meeting of the Society for Reproductive Investigation. March 2015; San Francisco, USA. Oral Presentation. 2014 • García-Herrero S, Mateu E, Milán M, Vera M, Campos-Galindo I, Peinado V, Rodrigo L, Simón C , Rubio C. Impact of male factor (MF) in the clinical outcome of repetitive implantation failure (RIF) patients undergoing comprehensive Chromosome Screening (CCS). Preimplantation Genetic Diagnosis International Society (PGDIS) Annual Meeting. April-May 2014; Canterbury, UK. Oral Presentation. • Mateu E, Rodrigo L, Al-Asmar N, Cinnioglu C, Peinado V, Milán M, García-Herrero S, Campos-Galindo I, Vera M, Simón C , Rubio C. Inter-chromosomal effect on day- 3 embryos and blastocysts from carriers of Robertsonian and reciprocal translocations. Preimplantation Genetic Diagnosis International Society (PGDIS) Annual Meeting. April-May 2014; Canterbury, UK. Poster Presentation. • Rubio C, Bellver J, Castillón G, Guillem A, Vidal C, Giles J, Remohí J, Pellicer A, Simón C . RCT study in advanced maternal age patients using array-CGH: interim analysis. 30th Annual Meeting of the European Society of Human Reproduction and Embryology. June-July 2014; Munich, Germany. Oral Presentation. • Gil-Sanchés, Cervelló I, Khurana S, Faus A, Verfaillie CM, Simón C . Endothelial progenitors and multipotent Oct4+ cells from bone marrow contributeto endometrial regeneration in an irradiated mice model. 30th Annual Meeting of the European Society of Human Reproduction and Embryology. June-July 2014; Munich, Germany. Oral Presentation. • Vera M, Michel CE, Mercader A, Kokocinski F, Rodrigo L, Bladon AJ, Mateu E, Al- Asmar N, Blesa D, Simón C , Rubio C. NGS vs. a CGH for the detection of segmental aneuploidies in human blastocyst. 30th Annual Meeting of the European Society of Human Reproduction and Embryology. June-July 2014; Munich, Germany. Oral Presentation. • Mir Pardo P, Banker M, Nahajan N, Chopra R, Khajuria R, Sachdeva K, Rodrigo L, Velasco JA, Simón C , Rubio C. Re-defining the concept of advanced maternal age in Indian patients with implantation failure. 30th Annual Meeting of the European Society of Human Reproduction and Embryology. June-July 2014; Munich, Germany. Poster Presentation. • Milán Sánchez M, Rodrigo L, Mateu E, Peinado V, García Herrero S, Campos
99 Galindo I, Poo ME, Simón C , Rubio C. What is the minimal number of MII oocytes or day-3 embryos for a successful comprehensive chromosomal screening (CCS) cycle. 30th Annual Meeting of the European Society of Human Reproduction and Embryology. June-July 2014; Munich, Germany. Poster Presentation. • Medrano JV, Martínez-Arroyo AM, Simón C . Human meiotic germ-like cells obtained by direct reprograming colonize the basal layer of mouse seminiferous tubules following germ cell xeno-transplantation. Gordon Research Conference. Mammalian reproduction. Translating basic science into clinical applications. August 2014; New London, USA. Poster Presentation. • Vilella F, Moreno M, Balaguer N, Pellicer A, Simón C . MicroRNAs secreted by the human endometrium regulates the transcriptome of the preimplantation embryo. Gordon Research Conference. Mammalian reproduction. Translating basic science into clinical applications. August 2014; New London, USA. Poster Presentation. • Riboldi M, Vera M, Michel CE, Al-Asmar N, Simón C , Rubio C. Validation of NGS technology for the detection of embryonic segmental aneuploidies. 18th Annual Congress of the Sociedade Brasileira de Reprodução Assistida. August 2014; Salvador, Brazil. Oral Presentation. • Riboldi M, Ruiz-Alonso M, Gómez-Sánchez E, Rincón-Bertolín A, Coprerski, Simón C. Role of endometrial receptivity array (ERA) in the orientation of personalized embryo transfer (pET). 18th Annual Congress of the Sociedade Brasileira de Reprodução Assistida. August 2014; Salvador, Brazil. Oral Presentation. • Riboldi M, Rodrigo L, Rubio C, Al-Asmar N, Coprerski B, Simón C . Impact of severe male factor in genetic screening preimplantation. 18th Annual Congress of the Sociedade Brasileira de Reprodução Assistida. August 2014; Salvador, Brazil. Poster Presentation. • Vera M, Chavez S, Rubio C, Reijo Pera R, Simón C . Prediction model for aneuploidy in early human embryos based on the transcriptomic signature. 70th American Society for Reproductive Medicine Annual Meeting. October 2014; Honolulu, Hawaii, USA. Oral Presentation. • Rubio C, Castillón G, Rodrigo L, Bellver J, Guillen A, Remohí J, Pellicer A, Simón C . Improvement of clinical outcome in severe male factor infertility with embryo selection based on Array-CGH: a randomized controlled trial. 70th American Society for Reproductive Medicine Annual Meeting. October 2014; Honolulu, Hawaii, USA. Oral Presentation. • Al-Asmar N, Vera M, Michel CE, Cinnioglu C, Blesa D, Simón C , Rubio C. NGS versus CGH for the detection of whole chromosome and segmental aneuploidies in human blastocysts. 70th American Society for Reproductive Medicine Annual Meeting. October 2014; Honolulu, Hawaii, USA. Oral Presentation. • Ruiz-Alonso M, Díaz-Gimeno P, Gómez E, Rincón-Bertolín A, Vladimirov Y, Garrido N, Simón C . Clinical efficiency of embryo transfer performed in receptive vs non- receptive endometrium diagnosed by the endometrial receptivity array (ERA) test. 70th American Society for Reproductive Medicine Annual Meeting. October 2014; Honolulu, Hawaii, USA. Poster Presentation • Garrido- Gomez T, Domínguez F, Quiñonero A, Padilla P, Perales A, Simón C . Decidualization defect in patients that suffered severe preeclampsia in mediated thorugh ANXA2 deficiency. 61st Annual Meeting Society for Gynecologic Investigation. March 2014; Florence, Italy. Oral Presentation. SGI President’s Presenter Awards • Genolet O, Cervello I, Gil-Sanchís C, Más A, Faus A, Moreno JM, Martínez-Conejero JA, Simón C . Gene expression profile of the Lgr5 cell population in the human endometrium. 61st Annual Meeting Society for Gynecologic Investigation. March 2014; Florence, Italy. Poster Presentation • Moreno-Moya JM, Vilella F, Pellicer A, Simón C . Proteomic regulation of has.miR- 30d over-expression in human endometrial epithelial cells (hEEC). 61st Annual Meeting Society for Gynecologic Investigation. March 2014; Florence, Italy. Poster Presentation • Moreno-Moya JM, Díaz-García C, Martínez S, Nuñez MJ, Simón C , Pellicer A,
100 Domínguez F. miRNAs Profiles of the human follicular fluid are differentially expressed according to the maturation stage of the oocyte. 61st Annual Meeting Society for Gynecologic Investigation. March 2014; Florence, Italy. Poster Presentation 2013 • Moreno-Moya JM, Vilella F, Martínez-Escribano S, Pellicer A, Simón C . Transcriptomic effects of hsa-miR-30d over-expression in human endometrial epithelial cells (hEEC). 60th Annual Meeting, Society for Gynecologic Investigation. March 2013; Orlando, Florida, USA. Oral Presentation • Domínguez F, Garrido-Gómez T, Quiñonero A, Antunez O, Sánchez Del Pino M, Simón C . Proteomic analysis of receptive versus non-receptive endometrial diagnosed by the endometrial receptivity array revealed differential protein profiles, highlighting the down-regulation of progesterone receptor membrane component 1 (PGRMC1). 60th Annual Meeting, Society for Gynecologic Investigation. March 2013; Orlando, Florida, USA. Poster Presentation ••• Garrido-Gómez T, Domínguez F, Quiñonero A, Simón C . ANXA2 inhibition disrupts endometrial stromal cells (ESCs) decidualization. 60th Annual Meeting, Society for Gynecologic Investigation. March 2013; Orlando, Florida, USA. Poster Presentation ••• Ramírez L, Vilella F, Martínez S, Pellicer A, Simón C . EP2 and FP receptor activation promote blastocyst adhesiveness to endometrial epithelial cells. 60th Annual Meeting, Society for Gynecologic Investigation. March 2013; Orlando, Florida, USA. Poster Presentation ••• García-Pascual CM, Zimmermann RC, Ferrero H, Shawber CJ, Simón C , Pellicer A, Gómez R. Notch pathway promotes and controls uterine decidual angiogenesis during early pregnancy in mouse. 60th Annual Meeting, Society for Gynecologic Investigation. March 2013; Orlando, Florida, USA. Poster Presentation • Milán M, Rubio C, Rodrigo L, Mateu E, Peinado V, Campos I, García-Herrero S, Simón C . Age related chromosomal abnormalities in preimplantation embryos assessed by a CGH. 9th European Cytogenetics Conference. June – July 2013; Dublin, Ireland. Poster Presentation ••• Mir P, Rodrigo L, Mateu E, Peinado V, Milán-Sánchez M, Al-Asmar N, García- Herrero S, Campos-Galindo I, Mercader A, Poo ME, Simón C , Rubio C. Re-analysis of whole day-5 embryos using the same arrayCGH platform used for day-3 diagnosis showed a high confirmation rate. 29th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2013; London, UK. Oral Presentation ••• Bermejo A, Iglesias C, Cerillo M, Ruiz M, Blesa D, Simón C , García-Velasco JA. Impact of oral contraceptive pill (OCP) for cycle scheduling on gene expression related to endometrial receptivity. 29th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2013; London, UK. Poster Presentation ••• Rubio C, Rodrigo L, Mateu E, Mercader A, Peinado V, Buendía P, Milán M, Delgado A, Al-Asmar N, Escrich L, Campos-Galindo I, García-Herrero S, Poo ME, Mir P, Simón C . Array-CGH versus FISH for PGS in recurrent miscarriage couples. 29th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2013; London, UK. Poster Presentation ••• Rodrigo L, Rubio C, Mateu E, Peinado V, Milán M, Viloria T, Al-Asmar N, Mercader A, Buendía P, Delgado A, Escrich L, Martínez-Jabaloyas JM, Simón C , Gil-Salóm M. FISH on sperm to identify infertile male patients with higher aneuploidy risk. 29th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2013; London, UK. Poster Presentation ••• Ferrero H, Gómez R, García-Pascual CM, Simón C , Pellicer A. Dopamine receptor D2 agonist (D2-ag) post-transcripitonally inhibits VEGF production and secretion by lutein granulose cells through non classical D2 transduction pathways. 29th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2013; London, UK. Poster Presentation ••• Más A, Cervelló I, Gil-Sanchís C, Fau A, Casado M, Simón C . The truncated form of HMGA2 in myometrial cells induce leiomyoma formation. 69th American Society for
101 Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Oral Presentation ••• Martínez-Arroyo A, Medrano JV, Quiñonero A, Marqués-Marí AI, Simón C . Direct reprogramming of human somatic cells to meiotic germ cells. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Oral Presentation ••• Domínguez F, Lozoya T, Moreno-Moya JM, Martínez S, Simón C , Pellicer A. Differential mIRNA profiles of trophoblast tissue obtained in ectopic pregnancies. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Oral Presentation ••• Mateu E, Rodrigo L, Milán M, Mercader A, Simón C , Rubio C. Chromosomal abnormalities and clinical outcome in patients with advanced maternal age (AMA) using comprehensive chromosome screening (CCS). 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Oral Presentation ••• Vilella F, Moreno-Moya JM, Martínez S, Pellicer A, Simón C . MicroRNAs secreted by the human endometrium regulates the transcriptome of the preimplantation embryo. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Oral Presentation ••• Al-Asmar N, Rubio C, Peinado V, Campos-Galindo I, García-Herrero S, Simón C . Impact of the number of previous miscarriages on the clinical outcome of recurrent miscarriage couples undergoing comprehensive chromosome screening (CCS). 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Poster Presentation ••• Sánchez Ribas I, Domínguez F, Ojeda M, León Z, Ballesteros A, Simón C . Liquid chromatography coupled to mass spectrometry (LC-MS) analysis of embryo spent culture media from human t13, m13 and normal embryos do not reveal differences in their early lipid metabolism. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Poster Presentation ••• Ramirez LB, Vilella F, Calder PC, Ezcurra D, Macklon N, Simón C . Regulation of prostaglandins E2 and F2 α by CBR1 in the human endometrial fluid. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Poster Presentation ••• Vidal C, Martinez-Conejero JA, Giles J, Alama P, Pellicer A, Simón C . Endometrial gene signature in the window of implantation of frozen replacement and ovum donation cycles using GnRH-agonists or antagonists compared to natural cycles. 69th American Society for Reproductive Medicine Annual Meeting held Conjoint with International Federation of Fertility Societies. October 2013; Boston, Massachusetts, USA. Poster Presentation 2012 ••• Más A, Cervello I, Gil-Sanchís C, Faus A, Ferro J, Pellicer A, Simón C . Identification of novel genes implicated in leiomyoma formation by wide genomic analysis of side population cells. 59th Annual Meeting Society for Gynecologic Investigation. March 2012; San Diego, California, USA. Poster Presentation ••• Garrido-Gómez T, Domínguez F, Quiñonero A, Estella C, Vilella F, Simón C . Annexin A2 is critical for endometrial adhesiveness and embryo attachment in humans by activation of RhoA through F-actin regulation. 59th Annual Meeting Society for Gynecologic Investigation. March 2012; San Diego, California, USA. Poster Presentation ••• Tamarit G, Horcajadas JA, Martinez-Conejero JA, Arbones JM, Simón C , Pellicer A.
102 Endometrial apolipoprotein pattern is altered in obese women but not in plasma: implications in endometrial receptivity and embryo implantation. 59th Annual Meeting Society for Gynecologic Investigation. March 2012; San Diego, California, USA. Poster Presentation ••• Sánchez-Ribas I, Domínguez F, Puchades L, Riqueros M, Vime P, Ballesteros A, Simón C . Nuclear magnetic resonace analysis of embryo spent culture media form human trisomy 21, monosomy 21 and normal day 3 embryos reveal differences in their early metabolism. 59th Annual Meeting Society for Gynecologic Investigation. March 2012; San Diego, California, USA. Poster Presentation ••• García-Herrero S, Martínez-Conejero JA, Campos-Galindo I, Ayala-Alvarez G, Ruiz- Alonso M, Simón C , Rubio C. Aneuploidy detection in products of conception (POCS) and prenatal diagnosis by luminex® Technology. The 1st Biomarker Meeting in Reproductive Medicine: Emergence of a New Field. March 2012; Valencia, Spain. Poster Presentation ••• Gil-Sanchís C, Cervelló I, Santamaría X, Más A, Faus A, Garrido-Gómez T, Quiñonero A, Pellicer A, Simón C . Demostration of Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation (Basic Science Award for Oral Presentation) ••• Estella C, Herrer I, Moreno-Moya J, Quiñonero A, Pellicer A, Simón C . miRNA signature and dicer requirement during endometrial stromal decidualization. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation ••• Pellicer A, Gómez R, García-Velasco J, Simón C . The role for dopamine agonists. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation ••• Rodrigo L, Rubio C, Bellver J, Peinado L, Buendía P, Vidal C, Giles J, Domingo J, Remohí J, Pellicer A, Simón C . Improved take-home baby rate with preimplantation genetic screening in implantation failure couples: a prospective controlled trial in a properly characterized population28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation ••• Mateu E, Rodrigo L, Mir P, Campos I, Escrich L, Vera M, Remohí J, Pellicer A, Simón C . Aneuploidy screening by arrays-CGH in embryos from couples with recurrent miscarriage: incidence of segmental aneuploidies. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation ••• Bermejo A, Cerrillo M, Ortega I, Martínez-Conejero JA, Ruiz-Alonso M, Horcajadas JA, Simón C , García-Velasco JA. Endometrial Receptivity Arrays (ERA) with different luteal support protocols after triggering final oocyte maturation with GnRH agonist. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Oral Presentation ••• Rubio C, Mateu E, Milán M, Mercader A, Bosch E, Labarta E, Crespo J, Remohí J, Simón C , Pellicer A. Benefits of PGS in advanced maternal age patients: a prospective randomized trial in women between 41-44 years of age. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Poster Presentation ••• Mercader A, Garrido N, Rubio C, Buendía P, Delgado A, Escrich L, Poo ME, Simón C. Cumulative live birth rates per embryo transferred according to the type of prolonged cultura in a preimplantation genetic screening program. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Poster Presentation ••• Ferrero H, Gómez R, García-Pascual CM, Simón C , Gaytán F, Pellicer A. Dopamine receptor d2 agonist prevents OHSS modulating VEGF secretion by lutein granulosa cells at post-transcriptional level. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Poster
103 Presentation ••• García-Pascual CM, Zimmermann, Ferrero H, Simón C , Pellicer A, Gómez R. Inhibition of D114-mediated signaling induces abortion in mice due affection of decidual angiogenesis. 28th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2012; Istanbul, Turkey. Poster Presentation ••• Vilella F, Bradshaw H, Ramirez LB, Stuart JM, Martínez S, Simón C . A non-invasive diagnostic method of human endometrial receptivity based on a specific lipidomic profile in endometrial fluid. 68th Annual Meeting American Society for Reproductive Medicine. October 2012; San Diego, California, USA. Oral Presentation
••• Milán M, Garrido N, Rubio C, Simón C , Remohí J, Pellicer A. Benefits of preimplantation genetic screening (PGS) in advanced maternal age (AMA) women demonstrated by cumulative live-birth rates (CLBR) considering all the embryos replaced in consecutive cycles. 68th Annual Meeting American Society for Reproductive Medicine. October 2012; San Diego, California, USA. Oral Presentation ••• Vera M, Rodrigo L, Mercader A, Peinado V, Simón C , Rubio C. Blastocyst rates according to embryo fragmentation and aneuploidy assessed by array-CGH. 68th Annual Meeting American Society for Reproductive Medicine. October 2012; San Diego, California, USA. Poster Presentation • Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Vilella F, Pellicer A, Simón C . Personalizing embryo transfer (PET) using and endometrial customized array as diagnostic and therapeutic strategy in patients with implantation failure. 68th Annual Meeting American Society for Reproductive Medicine. October 2012; San Diego, California, USA. Poster Presentation • Cervelló I, Gil-Sanchís C, Más A, Faus A, Pellicer A, Simón C . Leucine-rich repeat- containing G-Protein coupled receptor (Lgr5): a putative human endometrial stem cell marker. Copenhagen Bioscience Conferences, a Novo Nordisk Foundation Initiative. 1st Conference The Stem Cell Niche Development and Disease. June 2012; Copenhagen, Denmark. Oral Presentation 2011 • Delgado A, Mercader A, Escrich L, Buendía P, Rodrigo L, Rubio C, Simón C , Remohí J, Pellicer A, Meseguer M. Embryo Morphology and development 96 hours after fertilization (day 4) strongly correlates with chromosomal aneuploidy. 4th International IVI Congress. April 2011; Valencia, Spain. Poster Presentation ••• Rubio c, Rodrigo L, Mercader A, De los Santos MJ, Mateu E, Bosch E, Simón C , Remohí J, Pellicer A. Randomized controlled trial in patients with repetitive implantation failure: day-5 embryo transfer with and without preimplantation genetic screening (PGS). 4th International IVI Congress. April 2011; Valencia, Spain. Poster Presentation • Sánchez-Ribas Inma, Riqueros M, Vime P, Jhonsson T, Ballesteros A, Simón C , Domínguez F. Metabolic profliling of human trisomy 21 and normal day 3 IVF embryos reveal diferencies in their early metabolism. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011;Miami Beach, USA. Poster Presentation • Berlanga O, Ramirez L, Martínez S, Quiñonero A, Pellicer A, Simón C . Endometrial PGE2 and PGF2 α production in mainly the result of PGH2 metabolism by specific prostaglandin synthases during the window of implantation. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Poster Presentation • Domínguez F, Yañez-Mo M, Quiñonero A, Martínez S, Palacín M, Cervero A, Pellicer A, Sánchez-Madrid F, Simón C . Human endometrial CD98 is essential for blastocyst adhesion. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Poster Presentation ••• Moreno-Moya JM, Martínez-Escribano S, Simón C , Horcajadas JA. Chemoattractant effects of different conditioned media from endometrial epithelial primary culture in the presence and the absence of glycodelin-A on human
104 trophoblast cell line JEG-3. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Poster Presentation • Martínez-Conejero JA, Domínguez F, Simón C , Horcajadas JA. Functional genomics differences between adhesive and non-adhesive endometrial epithelial cell lines. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Poster Presentation ••• Gómez R, Ferrero H, Delgado F, Simón C , Pellicer A, Gaytan F. Differential expression of dopamine receptor 2 (drd2) might account for higher risk of OHSS development. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Oral Presentation ••• Ferrero H, Gómez R, Delgado F, Simón C , Gaytan F, Pellicer A. Drd2 agonists prevents OHSS by reducing VEGF secretion through the activation of Drd2 in granulosa cells. 58th Annual Meeting of the Society for Gynecologic Investigation. March 2011; Miami Beach, USA. Poster Presentation ••• Cervelló I, Gil-Sanchís C, Más A, Santamaría X, Moscardó F, Sanz J, Higueras G Sanz MA, Pellicer A, Simón C . Endometrial versus bone marrow source of somatic stem cells in human endometrium. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Oral Presentation ••• García-Pascual CM, Zimmermann RC, Simón C , Sawber C, Pellicer A, Gómez R. The role of angiogenesis specific Notch in corpora lutea formation. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Oral Presentation ••• Mercader A, Buendía P, Delgado A, Escrich L, Amorocho B, Simón C , Remohí J, Pellicer A, Martín J, Rubio C. Novel indications for blastocyst biopsy in a preimplantation genetic diagnosis program. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Poster Presentation ••• Ferrero H, Gómez R, Delgado F, Simón C , Gaytán F, Pellicer A. Drd2 agonists prevents OHSS by reducing VEGF secretion through the activation of Drd2 in granulosa cells. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Poster Presentation
••• Mas A, Cervelló I, Gil-Sanchís C, Peris-Pardo L, Faus A, Ferro J, Pellicer A, Simón C. Identification and characterization of putative leiomyoma stem cells. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Poster Presentation ••• Medrano JV, Hguyen HN, Ramathal C, Simón C , Reijo-Pera RA. Overexpression of conserved RNA-binding proteins induces meiotic progression in germ cells differentiated from pluripotent human stem cells. 27th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2011; Stockholm, Sweden. Poster Presentation • Vilella F, Ramírez L, Berlanga O, Martínez S, Pellicer A, Simón C . Effects of PGE2 and PGF2 α on blastocyst adhesion to the human endometrial epithelium. 67th Annual Meeting American Society for Reproductive Medicine. October 2011; Orlando, Florida, USA. Oral Presentation • Riboldi M, Gómez E, Aguilar C, Gil-Salom M, Simón C . In vitro differentiation of haploid cells after spermatogonial co-culture with sertoli cells from adult human testes. 67th Annual Meeting American Society for Reproductive Medicine. October 2011; Orlando, Florida, USA. Oral Presentation ••• Estella C, Herrer I, Quiñonero A, Martínez S, Pellicer A, Simón C . Inhibition of histone deacetylases in human endometrial stromal cells promotes extracellular matriz remodelling and inhibits embryo invasion. 67th Annual Meeting American Society for Reproductive Medicine. October 2011; Orlando, Florida, USA. Poster Presentation ••• Estella C, Herrer I, Quiñonero A, Martínez S, Pellicer A, Simón C . The endometrial stromal decidualization miRNA signature. 67th Annual Meeting American Society for
105 Reproductive Medicine. October 2011; Orlando, Florida, USA. Poster Presentation 2010 • Pilla FR, Martínez S, Simón C , Horcajadas JÁ. Is sparc relevant in embryo- emdometrium dialogue? An in vitro and in vivo analysis. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Herraiz S, Pellicer B, Cauli O, Rodrigo R, Felipo V, Simón C , Pellicer A. Pre- and postnatal brain damage in preeclamptic animal model induced by gestational nitric oxide synthase inhibition. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Riboldi M, Medrano JV, Marqués-Marí AI, Gómez E, Ruiz V, Poo ME, Gil-Salom M, Simón C . Spermatogonial stem cell lines obtained from testicular biopsies. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Garrido-Gómez T, Domínguez F, Quiñonero A, Martínez-Conejero JA, López JA, Camafeita E, Pellicer A, Simón C . Proteomic and secretomic of human endometrial stromal cells in decidualization process. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Más A, Cervelló I, Gil-Sanchís C, Martínez A, Galán A, Ruiz V, Ferro J, O’Connor JE, Pellicer A, Simón C . Somatic stem cell lines from human endometrium. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Alamá P, Pellicer A, Simón C. Defining the gene expression signature for human endometrial receptivity. 57th Annual Meeting Society for Gynecologic Investigation. March 2010. Orlando, Florida, USA. Poster Presentation • Valbuena D, Sánchez E, Aguilar C, Poo Me, Marqués A, Medrano JV, Simón C . Efficiency of a xeno-free HESC cryopreservaton method. The 1st International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive cells, Tissue & Organs. April 2010. Valencia, Spain. Poster Presentation • Valbuena D, Poo ME, Aguilar C, Martínez S, Quiñonero A, Cobo A, Simón C . Vitrification of isolated mice and human blastómeras. The 1st International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive cells, Tissue & Organs. April 2010. Valencia, Spain. Poster Presentation • Ruiz-Vela A, Aguilar-Gallardo C, Soriano M, Martínez-Arroyo A, Rincón-Bertolín A, Ruiz V, Gómez E, Medrano J, García-Verdugo J, Simón C . Human Embryonic Stem Cell microenvironments trigger efficient metaplastic adipogenesis of cancer cells. 8th Annual Meeting International Society for Stem Cell Research. June 2010; San Francisco, USA. Poster Presentation • Galán A, Póo M, Valbuena D, Montaner D, Ruiz V, Aguilar C, Sánchez E, Gómez E, Dopazo J, Simón C . Comparative genome wide analysis of hESC derived from single blastomeres, morulas and blastocysts. 8th Annual Meeting International Society for Stem Cell Research. June 2010; San Francisco, USA. Poster Presentation • Garrido N, Bellver J, Remohí J, Simón C , Pellicer A. Cumulative live-birth rates considering the total number of embryos replaced in consecutive IVF cycles to evaluate IVF success likelihood. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Oral Presentation • Ferrero H, Gaytán F, Delgado-Rosas F, Gaytán M, Gómez R, Simón C , Pellicer A. Dopamine receptor 2 (drd2) activation inhibits VEGF secretion in granulosa luteinized cells: implications for OHSS treatment in low drd2 milieus. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Oral Presentation • Vidal C, Giles J, Remohí J, Simón C , Garrido N, Bellver J, Pellicer A. The use of GnRH antagonist in endometrial priming improves oocyte donation outcome. Results of a prospective-controlled trial. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Oral Presentation
106 • Delgado-Rosas F, Gómez R, Tamarit S, Abad A, Simón C , Pellicer A. Quinagolide induces regression of human peritoneal endometriotic lesions by enhancing fibrinolisis and decreasing angiogenesis an inflammation. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation ••• Horcajadas JA, Martinez-Conejero JA, Montesinos M, Morgan M, Fortuño S, Simón C, Pellicer A. Endometrial receptivity is not affected in women with adenomyosis: a functional genomics analysis. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation ••• Bosch E, Labarta E, Cruz F, Simón C , Remohí J, Pellicer A. Circulating progesterone levels at the end of ovarian stimulation related to ongoing pregnancy rate in different patients subpopulation. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation ••• Rubio C, Domingo J, Rodrigo L, Mercader A, De los Santos MJ, Pehlivan T, Bosch E, Fernández M, Simón C , Remohí J, Pellicer A. Potential benefits of PGS in recurrent implantation failure: a prospective controlled trial in a properly characterized population. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation ••• Gómez E, Riboldi M, Galán A, Medrano JV, Rubio MC, Martinez MC, Martínez- Jabaloyas, Pellicer A, Simón C . Spermatogonial stem cells line from a patient with Klinefelter’s Syndrome. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation ••• Riboldi M, Medrano JV, Marqués-Marí AI, Gómez E, Poo ME, Aguilar C, Pellicer A, Gil Salom M, Simón C . Spermatogonial stem cell lines form human testicular biopsies. 26th Annual Meeting European Society of Human Reproduction & Embryology. June 2010; Rome, Italy. Poster Presentation • Galán A, Montaner D, Poo ME, Ruiz V, Valbuena D, Simón C . Defining cell fate and embryonic genome activation by global single-cel CDNA analysis of blastomeres from 5 to 8-cell human embryos. 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Oral Presentation • Garrido N, Bellver J, Remohí J, Simón C , Pellicer A. Cumulative live-birth rates (CLBR) considering the total number of embryos replaced in 26504 consecutive ovum donation cycles (OD). 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Oral Presentation • Cobo A, Domínguez F, Castelló D, De los Santos JM, Simón C , Remohí J. Effect of vitrification on human oocytes: a metabolic profiling study. 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Oral Presentation ••• Berlanga O, Garrido T, Martínez S, Pellicer A, Bradshaw HB, Simón C . Lipidomic profiling of endometrial fluid as a non-invasive diagnostic tool of human endometrial receptivity. 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Poster Presentation ••• Díaz-Gimeno P, Martínez-Conejero JA, Garrido N, Pellicer A, Simón C , Horcajadas JA. The endometrial receptivity array (ERA) improves the endometrial dating and provides an objetive method for clinical evaluation. 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Poster Presentation ••• Mercader A, Buendía P, Delgado A, Escrich L, Pellicer A, Simón C . Co-culture with endometrial epithelial cells improves clinical outcome in patients younger than 41 years from PGD program. 66th Annual Meeting American Society for Reproductive Medicine. October 2010; Denver, USA. Poster Presentation 2009 • Cervello I, Navarro-Aguilar I, Delgado-Rosas F, Martínez-Conejero JA, Martínez- Romero, Santonja N, O’Connor JE, Pellicer A, Simón C . Side population is the somatic stem cell population in human endometrium. 56th Annual Meeting Society for Gynecologic Investigation. March 2009; Glasgow Scotland. Oral Presentation • Altmae S, Martínez-Conejero JA, Salumets A, Simón C , Horcajadas JA, Stavreus- Evers A. Endometrial gene expression analysis during the time of embryo
107 implantation in women with unexplained infertility. 56th Annual Meeting Society for Gynecologic Investigation. March 2009; Glasgow Scotland. Oral Presentation ••• Evans GE, Martínez-Conejero JA, Simón C , Horcajadas JA, Benny PS, Phillipson GTM, Sin IL. Gene Expression analysis in specific endometrial compartments – epithelial glands and stroma, during the window o implantation in fertile women. 56th Annual Meeting Society for Gynecologic Investigation. March 2009; Glasgow Scotland. Poster Presentation ••• Domínguez F, Yañez-Mo M, Quiñonero A, Martínez S, Sánchez-Madrid F, Simón C . A system biology approach reveals a relevant functionfor CD147 and CD98 in endometrial receptiveness and trophoblast adhesion. 56th Annual Meeting Society for Gynecologic Investigation. March 2009; Glasgow Scotland. Poster Presentation • Garrido T, Domínguez FD, Quiñonero A, Lopez JA, Camafeita E, Calvo E, Pellicer A, Simón C . Proteomic analysis of the human receptive vs nonreceptive endometrium unveiled a functional relevance of stathmin 1 and annexin a2. Reproductive Medicine and beyond. The 3rd International IVI Congress. May 2009; Madrid, Spain. Poster Presentation • Vidal C, Giles J, Simón C , Remohí J, Bellver J, Pellicer A. Use of antagonist GnRH in oocyte recipient endometrium preparation. Reproductive Medicine and beyond. The 3rd International IVI Congress. May 2009; Madrid, Spain. Oral Presentation • Díaz Gimeno P, Horcajadas JA, Esteban FJ, Martínez-Conejero JA, Simón C . A new genomics method for human endometrial receptivity diagnosis. Reproductive Medicine and beyond. The 3rd International IVI Congress. May 2009; Madrid, Spain. Poster Presentation • Pilla F, Martínez-Escribano S, Simón C , Horcajadas JA. Development of a new three dimensional (3D) in vitro model for embryonic invasion. Reproductive Medicine and beyond. The 3rd International IVI Congress. May 2009; Madrid, Spain. Poster Presentation • Mercader A, Rubio C, Buendía P, Delgado A, Escrich L, Remohí J, Pellicer A, Simón C. Improvement of a preimplantation genetic screening program with the co-culture of embryos with a monolayer of endometrial epithelial cells. 25th Annual Meeting of European Society of Human Reproduction & Embryology. June – July 2009; Amsterdam, The Netherlands. Poster Presentation • Delgado A, Mercader A, Buendía P, Escrich L, Simón C , Remohí J, Pellicer A, Meseguer M. Quantification of day-5 embryo morphology effect on implantation rate in a preimplantational genetic diagnosis (PGD) program. 25th Annual Meeting of European Society of Human Reproduction & Embryology. June – July 2009; Amsterdam, The Netherlands. Poster Presentation • Buendía P, Rubio C, Martínez M, Rodrigo L, Mateu E, Milán-Sánchez M, Mercader A, Delgado A, Escrich L, Simón C . Clinical outcome in patients with chromosomal rearrangements included in a PGD Program. 7th European Cytogenetics Conference. European Cytogeneticists Association (ECA). July 2009; Stockholm, Sweden. Poster Presentation ••• Cervello I, Mas Aymara, Gil-Sanchis C, Martínez-Romero A, Martínez-Escribano S, Cañete P, Domingo S, Bellver J, Ferro J, Pellicer A, O’Connor JE, Simón C . Adipogenic differentiation of side population cells from human endometrium. 7th Annual Meeting International Society for Stem Cell Research. July 2009; Barcelona, Spain. Poster Presentation • Póo ME, Aguilar C, Gómez E, Sánchez E, Medrano JV, Riboldi M, Marqués-Marí A, Galán A, Ruiz V, Enseñat-Waser R, Valbuena D, Simón C . Optimizing the derivation of HESC lines from single blastomere in human feeders. 7th Annual Meeting International Society for Stem Cell Research. July 2009; Barcelona, Spain. Poster Presentation ••• Riboldi M, Enseñat-Waser R, Medrano JV, Póo ME, Gómez E, Marqués-Marí A, Sánchez E, Galan A, Ballesteros A, Castillon G, Ferro J, Simón C . Reprogramming of human amniotic fluid mesenchymal stem cells by epigenetic mechanisms. 7th Annual Meeting International Society for Stem Cell Research. July 2009; Barcelona, Spain. Poster Presentation
108 • Galan A, Ruiz V, Póo ME, Esteban FJ, Aguilar C, Enseñat-Waser R, Riboldi M, Sánchez E, Marqués-Marí A, Medrano JV, Valbuena D, Simón C . Are Human Blastomeres Committed to Trophectoderm or Inner Cell Mass at 6-8 Cell Stage Embryo? 7th Annual Meeting International Society for Stem Cell Research. July 2009; Barcelona, Spain. Poster Presentation ••• Marqués-Marí A, Sánchez E, Póo ME, Galán A, Aguilar C, Gómez E, Ruiz V, Medrano JV, Riboldi M, Enseñat-Waser R, Valbuena D, Simón C . Human Embryonic Stem Cell Banking at the Valencia Node of the Spanish Stem Cell Bank. 7th Annual Meeting International Society for Stem Cell Research. July 2009; Barcelona, Spain. Poster Presentation • Evans GE, Martinez-Conejero JA, Benny PS, Phillipson GTM, Simón C , McNoe LA, Pearson JF, Horcajadas JA, Sin IL. Investigating the gene expression of specific cell compartments in the endometrium. 19th annual Queenstown Molecular Biology Meetings 2009. September 2009; Queenstown, New Zealand. Oral Presentation • Novella-Maestre E, Medrano JV, Sánchez-Serrano M, Teruel J, Simón C , Pellicer A. Germ line and pluripotency gene expression markers in adult ovarian cortex. 65th Annual Meeting of the American Society for Reproductive Medicine. October 2009; Atlanta, USA. Poster Presentation • Vidal C, Giles J, Simón C , Remohí J, Pellicer A. The use of antonist GnRH in endometrial priming improves oocyte donation outcome. 65th Annual Meeting of the American Society for Reproductive Medicine. October 2009; Atlanta, USA. Poster Presentation ••• Pellicer A, Sánchez M, Crespo J, Cobo A, Simón C . Dopamine agonists in endometriosis. 16th Annual meeting, The Middle East Fertility Society. November 2009; Cairo, Egypt. Oral Presentation ••• Pellicer A, Sánchez M, Crespo J, Cobo A, Simón C . Fertility preservation in breast cancer patients. 16th Annual meeting, The Middle East Fertility Society. November 2009; Cairo, Egypt. Oral Presentation 2008 • Cervello I, Martínez-Romero A, Martínez-Conejero JA, Martínez-Escribano JA, Horcajadas JA, Pellicer A, O’connor JE, Simón C . Is the side population phenotype an essential characteristic for the somatic stem cells in the human endometrium? 55th Annual meeting of the Society for Gynecologic Investigation. March 2008; San Diego, USA. Oral Presentation • Domínguez F, Quiñonero A, López JA, Camafeita E, Calvo E, Melo M, Horcajadas JA, Pellicer A, Simón C . Proteomic analysis of pre-receptive vs receptive human endomtrium. 55th Annual meeting of the Society for Gynecologic Investigation. March 2008; San Diego, USA. Poster Presentation • Rubio C, Rodrigo L, Mercader A, Mateu E, Buendía P, Peinado V, Delgado A, Milán M, Pehlivan T, Viloria T, Mir P, Simón C , Remohí J, Pellicer A. Repeated pregnancy loss. Eighth International Symposium. Preimplantation Genetic Diagnosis. April 2008; Barcelona, Spain. Oral Presentation • Mercader A, Rubio C, Alamá P, Delgado A, Gadea B, Pehlivan T, Bronet F, Simón C , Pellicer A, Remohí J. Incidence of embryo aneuploidies in two hormonal stimulation protocols. Eighth International Symposium. Preimplantation Genetic Diagnosis. April 2008; Barcelona, Spain. Oral Presentation • Budak TP, Rubio C, Rodrigo L, Mateu E, Mercader A, Buendía P, Viloria T, Remohí J, Simón C , Pellicer A. Cumulative experience with preimplantation genetic screening in implantation failure patients. ALPHA 2008, 7th Biennial Conference. May 2008; Istanbul, Turkey. Oral Presentation • Buendía P, Rubio C, Mercader A, Rodrigo L, Mateu E, Pehlivan T, Viloria T, Peinado V, Delgado A, Milán M, Gadea B, Simón C , Remohí J, Pellicer A. Identification of good prognostic factors for preimplantation genetic diagnosis in unexplained recurrent miscarriage couples. ALPHA 2008, 7th Biennial Conference. May 2008; Istanbul, Turkey. Oral Presentation • Riboldi M, Poo MA, Gómez E, Luengo S, Galán A, Simón C . Isolation and characterization of pluripotent cells from amniotic fluid of early miscarriage. 6th
109 International Society for Stem Cell Research Annual Meeting. June 2008; Philadelphia, USA. Poster Presentation • Portela-Perez S, Muñoz EA, Pabón D, Simón C , Remohí J, Pellicer A. The addition of LH to ovarian stimulation does not produce more premature endometrial maturation (PEM) than stimulation using FSH alone. 24th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2008; Barcelona, Spain. Poster Presentation • Garrido T, Domínguez F, Quiñonero A, Martínez JÁ, López E, Camafeita E, Calvo E, Melo M, Pellicer A, Simón C . Endometrial annexin A2 and Stathmin-1 protein profile are modified in the refractory endometrium induced by an IUD. 24th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2008; Barcelona, Spain. Poster Presentation • Bosch E, Labarta E, Crespo J, Simón C , Remohí J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rate in ovarian stimulation cycles for in vitro fertilization. Analysis of 4000 cycles. 24th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2008; Barcelona, Spain. Oral Presentation • Delgado F, Gómez R, Simón C , Gaytán F, Pellicer A. Expression and localization of the dopamine receptor 2 in ovaries of women at different risk of developing ovarian hyperstimulation syndrome. 24th Annual Meeting of the European Society of Human Reproduction and Embryology. July 2008; Barcelona, Spain. Poster Presentation ••• Sanchez-Ribas I, Dominguez F, Barr J, Castro A, Mato JM, Simón C . Metabolomic profile as a novel non-invasive tool for human embryo aneuploidy assessment. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Oral Presentation ••• Gomez R, Gonzalez-Izquierdo M, Delgado F, Remohi J, Simón C , Pellicer A. Squalene epoxidase inhibitors block increased vascular permeability in an ohss model without affecting luteal function. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Oral Presentation ••• Martínez-Conejero JA, Bourgain C, Pellicer A, Devroey P, Arce JC, Simón C . Morphological and genomic endometrial development with long-acting degarelix starting in the mid-luteal or early follicular phase compared to daily ganirelix starting in the mid-follicular phase. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Poster Presentation • Diaz-Gimeno P, Horcajadas JA, Martinez-Conejero JA, Medina I, Pellicer A, Simón C. Development of a customized array for the molecular diagnosis of human endometrial receptivity. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Poster Presentation ••• Peinado V, Rodrigo L, Mir P, Viloria T, Simón C , Pellicer A. chromosomal abnormalities in embryos and spermatozoa from patients with previous abnormal pregnancies. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Poster Presentation ••• Labarta E, Bosch E, Alamá P, Simón C , Remohí J, Pellicer A. Incidence of embryo aneuploidies in natural and stimulated cycles in the same oocyte donor. Preliminary results. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Oral Presentation • Vergara V, Garcia G, Meseguer M, Garrido N, Simón C , Pellicer A. The presence of uterine adenomyosis does not affect implantation in an oocyte donation program. 64th Annual Meeting of the American Society for Reproductive Medicine. November 2008; San Francisco, USA. Poster Presentation 2007 • Domínguez F, Gadea B, Montaner D, Horcajadas JA, Dopazo J, Pellicer A, Simón C. The Comparison between the human blastocyst secretome of sequential versus coculture IVF systems points to IL-6 as a predictor of implantation. 54th Annual Meeting, Society for Gynecologic Investigation. March 2007; Reno, Nevada. Oral Presentation • Horcajadas JA, Merelo JJ, Domínguez F, Molina S, Pellicer A, Simón C .
110 Endometrial Database (EDB), a new online tool for endometrial research. 54th Annual Meeting, Society for Gynecologic Investigation. March 2007; Reno, Nevada. Poster Presentation • Cervelló I, Martínez-Romero A, Martínez-Conejero JA, Martínez-Escribano S, Horcajadas JA, Pellicer A, Oconnor JE, Simón C . The molecular profile of stromal side population in human endometrium has the features of a progenitor stem cell population. 54th Annual Meeting, Society for Gynecologic Investigation. March 2007; Reno, Nevada. Poster Presentation • Martínez-Conejero JA, Meseguer M, Remohí J, Pellicer A, Simón C , Garrido N. The significance of sperm MUC1 in embryo development and reproductive outcome in an ovum donation program. XIX World Congress on Fertility & Sterility. April – May 2007; Durban, South Africa. Poster Presentation • Mercader A, Buendía P, Gadea B, Pehlivan T, Simón C , Remohí J, Pellicer A, Rubio C. Elective single embryo transfer vs. double embryo transfer in a PGD programme. Preimplantation Genetic Diagnosis International Society Conference. June 2007; Melbourne, Australia. Poster Presentation • Novella-Maestre E, Carda C, Noguera I, Ruiz-Sauri A, Simón C , Pellicer A. Antiangiogenic action of dopamine agonists in esperimentally-induced endometriotic lesions. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Oral Presentation • Loro F, Domínguez F, Quiñonero A, Martínez S, Pellicer A, Simón C . IP-10/CXCR3 at the human maternal fetal interface: a “chemoatractive” hypothesis. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Oral Presentation • Domínguez F, Gadea B, Horcajadas JA, Pellicer A, Simón C . Deciphering human secretome: protein profile of implanting blastocysts. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Oral Presentation. • Busso C, Budak EB, Melo MAB, Simón C , Pellicer A, Remohí J. Oocyte donation in patients with premature ovarian failure after chemotherapy and pelvic irradiation for Hodgkin’s and non Hodgkin’s disease. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Poster Presentation • Alvarez C, Fernández-Sánchez M, Alonso-Muriel I, Simón C , Pellicer A. Implantation is not affected in women receiving cabergoline (Cb2) to prevent ovarian hyperstimulation syndrome (OHSS) in high-risk ART patients. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Poster Presentation • Horcajadas JA, Requena A, Pacheco A, Mayoral M, Martínez-Conejero JA, Pellicer A, Simón C . The effect of menopur vs rfsh in the genomics of human endometrium. 23rd Annual Meeting of the European Society of Human Reproduction and Embryology. July 2007; Lyon, France. Poster Presentation • Krtolica A, Ilic D, Foulk R, Caceres E, Simón C , Genbacev O. Derivation of the first custom-made personal embryonic stem cells. A pilot study. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Oral Presentation • Ilic D, Genbacev O, Simón C , Foulk R, Krtolica A. Derivation of the human embryonic stem cells line from the two blastomeres of non-viable embryos. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Oral Presentation • Bosch E, Rubio MC, Mercader A, Simón C , Remohí J, Pellicer A. Embryo aneuploidies in GnRH agosnist vs. GnRH antagonist cycles. Experience of 2000 cycles. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Oral Presentation • Novella-Maestre E, Simón C , Pellicer A. Modulation of angiogenesis by the dopamine agonist cabergoline in experimentally-induced peritoneal endometric lesions. 63rd Annual Meeting, American Society for Reproductive Medicine. October
111 2007; Washington, USA. Oral Presentation • Horcajadas JA, Mínguez P, Dopazo J, Esteban FJ, Pellicer A, Simón C . Gene expression analysis of the indometrium reveals that controlled ovarian stimulation induces a genomic delay with potential clinical implications. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Oral Presentation • Higón MA, Horcajadas JA, Martínez-Conejero JA, Simón C , Pellicer A. The Impact of single intramural myomas on endometrial receptivity: a histological and genomic analysis. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Oral Presentation • Delgado A, De los Santos MJ, Buendía P, Simón C , Remohí J, Pellicer A. Increased incidence of mosaic embryos with the microinjection of spermatozoa with abnormal morphology. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Poster Presentation • Labarta E, Bosch E, Simón C , Remohí J, Pellicer A. A prospective, randomized controlled trial comparing highly purified hMG with recombinant FSH + recombinant LH in women undergoing intrauterine insemination: ovarian response and clinical outcomes. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Poster Presentation • Ilic D, Simón C , Genbacev O, Caceres E, Foulk R, Krtolica A. Embryos from the same patients yield both normal and aneuploid lines under indentical culture conditions. 63rd Annual Meeting, American Society for Reproductive Medicine. October 2007; Washington, USA. Poster Presentation • Loro F, Domínguez F, López JA, Camafeita E, Calvo E, Melo M, Horcajadas JA, Pellicer A, Simón C Proteomic analysis of pre-receptive vs receptive human edometrium. 2nd Society for Gynecologic Investigation (SGI) International summit on Reproductive Medicine. “From embryo and endometrium to implantation: the translational research. November 2007; Valencia, Spain. Poster Presentation • Cervelló I, Martínez-Conejero JA, Martínez-Escribano Sebastián Martínez-Romero A, Delgado-Rosas FM, Riboldi M, Horcajadas JA, Cañete P, O’Connor JE, Pellicer A, Simón C . In the human endometrium the percentage of stromal side population does not correlate with the age2nd Society for Gynecologic Investigation (SGI) International summit on Reproductive Medicine. “From embryo and endometrium to implantation: the translational research. November 2007; Valencia, Spain. Poster Presentation • Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Pellicer A, Simón C . Development of a customized array for endometrial receptivity (ERA) 2nd Society for Gynecologic Investigation (SGI) International summit on Reproductive Medicine. “From embryo and endometrium to implantation: the translational research. November 2007; Valencia, Spain. Poster Presentation • Herraiz S, Pellicer B, Migue Asensi, Felipo V, Morcillo E, Simón C , Pellicer A. Sildenafil effects in normal pregnancy and preeclampsia employing an animal model. 2nd Society for Gynecologic Investigation (SGI) International summit on Reproductive Medicine. “From embryo and endometrium to implantation: the translational research. November 2007; Valencia, Spain. Poster Presentation 2006 • Cervello I, Martínez-Conejero JA, Pellicer A, Simón C . Identification quantification and co-localization of the BrdU retained cells with Oct3/4 in the murine endometrium. 53rd Annual Meeting of the Society for Gynecologic Investigation. March 2006; Toronto, Canada. Poster Presentation • Cervero A, Quiñonero A, Domínguez F, Horcajadas JA, Pellicer A, Simón C . Interference of endometrial leptin receptor mRNA expression reduces the adhesion rate of mice embryos to a human endometrial cell line. 53rd Annual Meeting of the Society for Gynecologic Investigation. March 2006; Toronto, Canada. Poster Presentation • Horcajadas JA, Riesewijk A, Mínguez P, Dopazo J, Polman J, Pellicer A, Simón C .
112 Comparison of the endometrial gene expression profile throughout the window of implantation in natural vs. COH cycles. 22nd Annual Meeting, European Society of Human Reproduction and Embryology. June 2006; Prague, Czech Republic. Oral Presentation • Meseguer M, De los Santos MJ, Simón C , Remohí J, Pellicer A, Garrido N. Sperm glutathione peroxidases-1 and -4 are correlated with embryo asymmetry and blastocyst quality in oocyte donation cycles. 22nd Annual Meeting, European Society of Human Reproduction and Embryology. June 2006; Prague, Czech Republic. Oral Presentation • Alvarez C, Bosch E, Melo MAB, Fernández-Sánchez M, Muñoz EA, Remohí J, Simón C , Pellicer A. The dopamine agonist Cabergoline prevents moderate-severe early ovarian hyperstimulation síndrome (OHSS) in high-risk ART patients. 22nd Annual Meeting, European Society of Human Reproduction and Embryology. June 2006; Prague, Czech Republic. Oral Presentation • Mercader A, Buendía P, Gadea B, Phelivan T, Remohí J, Pellicer A, Rubio C, Simón C. Co-culture improves blastocyst rate from biosied embryos. 22nd Annual Meeting, European Society of Human Reproduction and Embryology. June 2006; Prague, Czech Republic. Poster Presentation • Rodrigo L, Rubio C, Mateu E, Viloria T, Peinado V, Remohí J, Pellicer A, Simón C , Gil-Salom M. Predictive value of sperm FISH analysis on the incidence of day 3 abnormal embryos in severe male factor couples. 22nd Annual Meeting, European Society of Human Reproduction and Embryology. June 2006; Prague, Czech Republic. Poster Presentation • Gómez R, González M, Zimmermann R, Remohí J, Simón C , Pellicer A. Seggregation of the antiapermeability and the antiangiogenic effects derived from VEGFR2 blockade by cabergoline. A specific non-toxic approach to treat OHSS. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Oral Presentation • Horcajadas JA, Mínguez P, Riesewijk A, Dopazo J, Pellicer A, Simón C . Functional genomics of the human endometrial development during the window of implantation. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Oral Presentation • Labarta E, Bosch E, Simón C , Remohí J, Pellicer A. The value of estradiol: oocyte ratio as predictor of in vitro fertilization-embryo transfer outcome. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Poster Presentation • Martínez-Conejero JA, Cervelló I, Garrido N, Meseguer M, Remohí J, Pellicer A, Simón C . Identification of the progenitor stem cell population in the murine testis reveal that slow cycling cells do not correlate with side population. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Poster Presentation • Labarta E, Bosch E, De los Santos MJ, Simón C , Remohí J, Pellicer A. Premature luteinization in GnRH antagonist cycles: outcome according to day of embryo transfer. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Poster Presentation • Álvarez C, González S, Crespo J, Simón C , Remohí J, Pellicer A. Cabergoline (CB2) administration to prevent ovarian hiperstimulation síndrome (OHSS) in IVF ICSI does not reduce implantation and pregnancy rates. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Poster Presentation • Pehlivan TS, Mercader A, De los Santos MJ, Remohí J, Pellicer A, Simón C . Comparison of two different treatment options for implantation failure patients: preimplantation genetic diagnosis versus blastocyst transfer. 62nd Annual Meeting, American Society for Reproductive Medicine. October 2006; Nueva Orleans, USA. Poster Presentation. 2005 • Oberyé J, Riesewijk A, Simón C , Pellicer A. Endometrial gene expression after
113 treatment with standard or high dose GnRH antagonist is similar and comparable to non-stimulated cycles. 8th International Symposium on GnRH Analogues in Cancer and Human Reproduction. February 2005; Salzburg, Austria. Oral Presentation
• Coelingh Bennink H.J.T, Olivennes F, Simón C . An old hormone and a new oral GnRH antagonist for IVF. 8th International Symposium on GnRH Analogues in Cancer and Human Reproduction. February 2005; Salzburg, Austria. Oral Presentation • Simón C , Escobedo C, Valbuena D, Genbacev O, Galán A, Krotolica A, Asensi A, Sánchez E, Esplugues J, Fisher S, Pellicer A. First derivation in Spain of human embryonic stem cell lines: use of long term cryopreserved embryos and animal free conditions. Stem cell 2005. Progress to therapy? March 2005; Edinburgh, Scotland. Oral and poster Presentation • Martínez-Conejero JA, Cervello I, Pellicer A, Remohí J, Simón C . Identification, localization and characterization of the progenitor stem cell population in the murine testis. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Oral Presentation • Gómez-Gallego R, González M, Alonso-Muriel I, Novella E, Sánchez-Criado J, Remohí J, Simón C , Zimmermann R, Pellicer A. Cabergoline administration is a non-toxic and specific approach to effectively treat OHSS. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Oral Presentation • Cervello I, Martínez-Conejero JA, Escobedo C, Cervero A, Pellicer A, Simón C . Identification, characterization and colocalization of the progenitor stem cell population in the murine endometrium. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Oral Presentation • Horcajadas JA, Domínguez F, Cervero A, Pellicer A, Simón C . Comparison of wide genome analysis in endometrium among natural (fertile), IVF (subfertile) an IUD (non fertile) cycles at the time of implantation. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Oral Presentation • Escobedo-Lucea C, Valbuena D, Galán A, Genvaceb O, Sánchez E, Krtolica A, Fisher S, Moreno R, Pellicer A, Simón C . First derivation in Spain of human embryonic stem cell lines using of long-term cryopreserved embryos and animal-free conditions. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Poster Presentation • Novella-Maestre E, Gómez-Gallego R, Alonso-Muriel I, González M, Sánchez- Criado JE, Remohí J, Simón C , Pellicer A. Progesterone has no role in the increased vascular permeability which onsets OHSS. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Poster Presentation. • Alonso-Muriel I, Gómez-Gallego R, Pau E, Novella E, Ruiz A, Remohí J, Simón C , Pellicer A. Free VEGF but not total VEGF is responsible for ovarian hyperstimulation syndrome (OHSS) onset. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Poster Presentation • Domínguez F, Yañez-Mo M, Sánchez-Madrid F, Pellicer A, Simón C . Protein profiles of 40 membrane proteins involved in endometrial receptivity in RL-95-2, HEC-1-A and primary EEC. 52nd Annual Meeting, Society for Gynecologic Investigation. March 2005; Los Angeles, California, USA. Poster Presentation • Pehlivan T, Rubio C, Rodrigo L, Mercader A, Mateu E, Simón C , Remohí J, Pellicer A. The role of preimplantation genetic diagnosis (PGD) in recurrent miscarriage couples. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral Presentation • Bosch E, Rubio C, Mercader A, Simón C , Remohí J, Pellicer A. GnRH antagonists do not increase embryo aneuploidies incidence. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral
114 Presentation • Budak E, Fernández M, Reis S, Bosch E, Simón C , Remohí J, Pellicer A. Effect of duration of estradiol valerate (EV) administration for endometrial preparation in donor oocyte cycles. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral Presentation • Budak E, Bellver J, Simón C , Remohí J, Pellicer A. Reduced multiple pregnancy rates following 2 embryo transfer on day 3. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral Presentation • Pehlivan T, Calderón G, Prados N, Crespo M, Simón C , Remohí J, Pellicer A. The effect of multinucleation in day-2 embryos on IVF outcome. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral Presentation • Budak E, Fernández M, Reis S, Bosch E, Simón C , Remohí J, Pellicer A. Effects of advanced recipient age on ART success and obstetric outcome. 13th World Congress on In Vitro Fertilization, Assisted Reproduction & Genetics. May 2005; Istanbul, Turkey. Oral Presentation • Bosch E, Vidal C, Crespo J, Simón C , Remohí J, Pellicer A. Highly purified HMG versus rec-FSH in GnRH antagonist cycles. 21st Annual Meeting of the European Society of Human Reproduction and Embryology. June 2005; Copenhagen, Denmark. Poster Presentation • Pau E, Alonso-Muriel I, Gómez R, Novella E, Ruiz A, Simón C , Pellicer A. Comparison of pregnancies after IVF and oocyte donation shows that the ovary acts as a paracrine organ in cases of LO-OHSS. 21st Annual Meeting of the European Society of Human Reproduction and Embryology. June 2005; Copenhagen, Denmark. Poster Presentation • Rubio C, Rodrigo L, Gil-Salom M, Mateu E, Mercader A, Buendía P, Simón C , Remohí J, Pellicer A. Sperm chromosomal abnormalities and PGD: relationship with sperm parameters. 21st Annual Meeting of the European Society of Human Reproduction and Embryology. June 2005; Copenhagen, Denmark. Poster Presentation • Galán-Albiñana A, Escobedo-Lucea C, Valbuena D, Sánchez E, Pellicer A, Moreno R, Simón C . Genetic and Immunological profile of two sister HESC lines, VAL-1 and VAL-2, in undifferentiated and differentiated stage. 3rd Annual Meeting International Society for Stem Cell Research. June 2005; San Francisco, USA. Poster Presentation • Escobedo-Lucea C, Valbuena D, Galán A, Gómez E, Berna A, Genbacev O, Pellicer A, Moreno R, Simón C . Ultrastructure of two sister HESC lines, VAL-1 and VAL-2 in undifferentiated and differentiated stages. 3rd Annual Meeting International Society for Stem Cell Research. 3rd Annual Meeting International Society for Stem Cell Research. June 2005; San Francisco, USA. Poster Presentation • Genbacev O, Escobedo-Lucea C, Zdravkovic T, Nordstrom A, Valbuena D, Nath A, Galán A, Simón C , Fisher SJ. Maintenance of “stemness” is associated with polarization of blastocyst-derived human embryonic stem cell lines. 3rd Annual Meeting International Society for Stem Cell Research. June 2005; San Francisco, USA. Poster Presentation • Valbuena D, Galán A, Escobedo-Lucea C, Genbacev O, Krtolica A, Fisher SJ, Sánchez-Luengo S, Gómez AL, Pellicer A, Moreno R, Simón C . An efficient slow freezing HESC cryopreservation method. 3rd Annual Meeting International Society for Stem Cell Research. June 2005; San Francisco, USA. Poster Presentation • Martínez-Conejero JA, Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. MUC1 expression in human testis is directly related with fertile status. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Oral Presentation • Horcajadas JA, Catalano R, Gadea B, Sharkey A, Pellicer A, Simón C . The human embryo-endometrial dialogue: impact of a single blastocyst in the gene expression
115 pattern of endometrial epithelial cells. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Oral Presentation • Meseguer M, De Los Santos MJ, Simón C , Pellicer A, Remohí J, Garrido N. Sperm quality is comparable among those oncological males diagnosed regardless of the cancer types. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation • Melo MA, Meseguer M, Simón C , Pellicer A, Remohí J, Garrido N. Stimulation length, number of high-sized follicules and estradiol on the hCG injection day are multiple pregnancy risk factors in IUI. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation • Bosch E, Ruiz A, Crespo J, Simón C , Pellicer A, Remohí J. Coordination and results of a global ovum donation program. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation • Vidal C, Zuzuarregui J, Epifanio R, Simón C , Remohí J, Pellicer A. Urinary human chorionic gonadotropin (hCG), intramuscular or subcutaneously administered, yields higher hCG serum and follicular levels than recombinant hCG in egg donors. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation • Mercader A, Rubio C, Rodrigo L, Mateu E, Simón C , Pellicer A. Could donor insemination failure be and indication for preimplantation genetic diagnosis (PGD)? Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation • Cervero A, Horcajadas JA, Catalano R, Sharkey A, Pellicer A, Simón C . Gene expression pattern induced by leptin in human endometrial epithelial cells. Conjoint Annual Meeting, American Society for Reproductive Medicine (ASRM) & Canadian Fertility and Andrology Society (CFAS). October 2005; Montreal, Canada. Poster Presentation 2004 • Meseguer M, Garrido N, Zuzuarregui JL, Pellicer A, Simón C , Remohí J. Infectious diseases and genetic disorders found in the routinely screening in an ovum donation programme: experience from 10 years follow-up of 1991 candidates. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Bosch E, Troncoso C, Bellver J, Vidal C, Crespo J, Simón C , Pellicer A, Remohí J. Multivariate analysis of factors predicitng success in Egg donation. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Escribá MJ, Ferri MJ, Urios C, Romero JL, Bosch E, Simón C , Pellicer A, Remohí J. Timing for artificial luteal phase set up in EGG donation program. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Soares SR, Rubio C, Rodrigo L, Simón C , Remohí J, Pellicer A. Frecuency of chromosomal abnormalities in embryos obtained from oocyte donation cycles. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Epifanio R, Troncoso C, Bosch E, Rodríguez M, Remohí J, Pellicer A, Simón C . Reproductive outcome and obstetric evolution in women over 50 undergoing ovum donation. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Troncoso C, Bosch E, Epifanio R, Aizpurua J, Castillón G, Simón C , Pellicer A. Endometrial thickness and serum oestradiol serum level as predictors of sucess in
116 oocyte donation. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • Castillón G, Rabadán S, Reis Soares S, Ramírez A, Bosch E, Simón C , Pellicer A, Remohí J. Advances in recipients endometrial preparation. 2nd Annual International Egg Donation Conference. February 2004; Valencia, Spain. Oral Presentation • García-Velasco JA, Zúñiga A, Pacheco A, Gómez R, Remohí J, Simón C , Pellicer A. Coasting reduces the incidence of OHSS by inducing apoptosis in small-medium follicules. 51st Annual Meeting, Society for Gynecologic Investigation. March 2004; Houston, USA. Poster Presentation • Domínguez F, Castrillo JL, Avila Silvia, Pellicer A, Simón C . RNA interference reduces IGFBP-rP1 expression in Rl95-2 cells. 51st Annual Meeting, Society for Gynecologic Investigation. March 2004; Houston, USA. Poster Presentation • Martínez-Conejero JA, Garrido N, Remohí J, Pellicer A, Simón C , Meseguer M. The MUC1 mucin is present on the human sperm surface. 20th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). June 2004; Berlin, Germany. Poster Presentation • Boerrigter P, Escudero E, Coelingh Bennink H, Pellicer A, Olivennes F, Simón C . Mifepristone is an affective oral alternative to prevent premature LH surges in controlled ovarian hyperstimulation. 20th annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). June 2004; Berlin, Germany. Poster Presentation • Simón C , Bellver J, Vidal C, Bosch E, Martín J, Horcajadas JA, Murphy C, Riesewijk A, Oberyé J, Mannaerts B, Pellicer A. Similar endometrial development in oocyte donors after daily treatment with high- or low-dose GnRH antagonist compared to GnRH agonist and natural cycles. 20th annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). June 2004; Berlin, Germany. Oral Presentation • Garrido, Meseguer M, Simón C , Remohí J, Pellicer A. Report of the results of a two-year program of sperm wash and intracytoplasmic sperm injection (ICSI) for human immunodeficiency virus (HIV) serodiscordant copules. 20th annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). June 2004; Berlin, Germany. Oral Presentation • Soares SR, Troncoso C, Bosch E, Simón C , Pellicer A. Age and uterine receptiviness in oocyte donation. 20th annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). June 2004; Berlin, Germany. Oral Presentation • Horcajadas JA, Riesewijk A, Polman J, Mosselman S, Pellicer A, Simón C . Impact of controlled ovarian hyperstimulation on endometrial gene expression profiles during the window of implantation. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Oral Presentation • Horcajadas JA, Catalano R, Burgos A, Sharkey A, Pellicer A, Simón C . Functional genomics of endometrial receptivity using an interceptive approach. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Oral Presentation • Vidal C, Rubio C, Crespo J, Simón C , Remohí J, Pellicer A. Increased incidence of chromosomal abnormalities in embryos from polycystic ovarian syndrome patients. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Oral Presentation • Meseguer M, Garrido N, Martínez-Conejero JA, Simón C , Pellicer A, Remohí J. Ca+2 and cholesterol and mitochondrial activity in sperm from fertile and infertile men. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation • Gómez R, González M, Sánchez-Criado J, Simón C , Remohí J, Pellicer A. Dopamine (D) agonist (A) administration diminishes increased vascular permeability (iVP) in ovarian hyperstimulation sindrome (OHSS) animals by blocking vascular endothelial growth factor receptor 2 (VEGFR2) phosporylation (ph). 60th Annual
117 Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation • Molina NK, Zuzuarregui JL, Simón C , Remohí J, Pellicer A. Early pregnancy loss in preimplantatory genetic diagnosis. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation • García-Velasco JA, Duque L, Moreno A, Zúñiga A, Requena A, Simón C . Coasting: the experience with the antagonist. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation • Muñoz EA, Garrido N, Melo MA, Simón C , Pellicer A, Remohí J. The importance of difficult embryo transfer: A comparison in recipients of shared oocytes. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation • Bosch E, Pau E, Crespo J, Simón C , Remohí J, Pellicer A. Premature luteinization in GnRH antagonist cycles in oocyte donors and its relationship to recipients cycle outcome. 60th Annual Meeting of the American Society for Reproductive Medicine. October 2004; Pennsylvania, Philadelphia, USA. Poster Presentation 2003 ••• Domínguez F, Luna JJ, Pellicer A, Simón C . Chemokine receptor expression and localization in human endometrium. 50th Annual Meeting, Society for Gynecologic Investigation. March 2003; Washington. DC., USA. Poster Presentation • Cervero A, Horcajadas JA, Martín J, De Pablo JL, Escriba MJ, Pellicer A, Simón C . Leptin and leptin receptor in human endometrium and preimplantation embryos. 50th Annual Meeting, Society for Gynecologic Investigation. March 2003; Washington. DC., USA. Poster Presentation ••• Escobedo C, García-Verdugo JM, Escriba MJ, Pellicer A, Simón C . Ultrastructural study of the human blastocyst. 50th Annual Meeting, Society for Gynecologic Investigation. March 2003; Washington. DC., USA. Poster Presentation • Luna JJ, Horcajadas JA, Domínguez F, Remohí J, Pellicer A, Simón C . Relaxin receptor LGR-7 mRNA expression and localization in human endometrium through the menstrual cycle. 50th Annual Meeting, Society for Gynecologic Investigation. March 2003; Washington. DC., USA. Poster Presentation • Domínguez F, Cervero A, Avila S, Castrillo JL, Pellicer A, Simón C . IGFBP-rP1 expression and localization througout the human menstrual cycle. 50th Annual Meeting, Society for Gynecologic Investigation. March 2003; Washington. DC., USA. Poster Presentation • Marí M, Garrido N, Pellicer A, Remohí J, Simón C , Meseguer M. A prospective randomized study comparing sperm-grad vs. pure-sperm for density gradient separation of human spermatozoa in assisted reproduction.15th IFCC- FESCC European Congress of Clinical Cemistry and Laboratory Medicine. 22th National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology. June 2003; Barcelona, Spain. Poster Presentation • Marí M, Meseguer M, Pellicer A, Remohí J, Simón C , Garrido N. A prospective randomized study comparing sperm-rinse vs. sperm for swim-up capacitation of human spermatozoa in assisted reproduction. 15th IFCC- FESCC European Congress of Clinical Cemistry and Laboratory Medicine. 22th National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology. June 2003; Barcelona, Spain. Poster Presentation • Gómez R, González M, Simón C , Remohí J, Pellicer A. Ovarian hyperstimulation syndrome (OHSS) is related to the upregulation of rate steps enzymes limiting ovarian cholesterol biosynthesis. III International Workshop on Human Implantation: Discovery in the Reproductive Tract in Health and Disease Using Genomics/Proteomics. June 2003; Madrid, Spain. Poster Presentation • Martín J, Domínguez F, Ávila S, Pellicer A, Castrillo JL, Simón C . cDNA Microarray analysis of human endometrial tissue shows the differential expression of GADD45A apoptosis-related gene in receptive endometrial. III International Workshop on
118 Human Implantation: Discovery in the Reproductive Tract in Health and Disease Using Genomics/Proteomics. June 2003; Madrid, Spain. Poster Presentation • Luna JJ, Horcajadas JA, Domínguez F, Remohí J, Pellicer A, Simón C . Gene Expresión pattern and immunoreactive protein localization of LGR7. Receptor in Human endometrium throughout the menstrual cycle. III International Workshop on Human Implantation: Discovery in the Reproductive Tract in Health and Disease Using Genomics/Proteomics. June 2003; Madrid, Spain. Poster Presentation • Reis Soares S, Rubio C, Rodrigo L, Mateu E, Mercader A, Simón C , Remohí J, Pellicer A. Does preimplantation genetic diagnosis improve the outcome of egg donation cycles?. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Poster Presentation • Rodrigo L, Rubio C, Gil-Salom M, Mateu E, Pérez-Cano I, Herrer R, Simón C , Remohí J, Pellicer A. Sperm chromosomal abnormalities: a new indication for preimplantation genetic diagnosis?. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Poster Presentation • Diaz I, Guillén A, Pacheco A, Requena A, Simón C , García-Velasco J. Final oocyte maturation with GnRH agonist versus HCG in intrauterine insemination. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Poster Presentation • Bellver J, Muñoz E, Ballesteros A, Reis S, Bosch E, Vidal C, Simón C , Remohí J. Intravenous albumin does not prevent moderate-severe OHSS. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Poster Presentation • Epifanio RE, Troncoso C, Escudero E, Remohí J, Pellicer A, Simón C . Reproductive outcome and obstetric evolution in women >50 undergoing oocyte donation. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Poster Presentation • Bosch E, Escudero E, Crespo J, Simón C , Remohí J, Pellicer A. Serum LH in ovarian stimulation with GnRH antagonists. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Oral Presentation • De los Santos MJ, Valencia I, Simón C , Remohí J, Pelllicer A. Premature luteinization does not affect embryo quality in GnRH antagonists cycles. 19th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting. June – July 2003; Madrid, Spain. Oral Presentation • Meseguer M, Garrido N, Simón C , Pellicer A, Remohí J. Glutathione peroxidase 4 activity but not expression is lower in infertile males than normal fertile controls. 3rd Joint Meeting of the British Andrology Society, the British Fertility Society and the Society for Reproduction and Fertility. July 2003; Aberdeen, Scotland. Poster Presentation • Garrido N, Meseguer M, Simón C , Remohí J, Pellicer A. Seminal glutathione system (glutathione peroxidases 1 and 4, and glutathione reductase) expression and activity is not correlated with classical semen parameters. 3rd Joint Meeting of the British Andrology Society, the British Fertility Society and the Society for Reproduction and Fertility. July 2003; Aberdeen, Scotland. Poster Presentation • Domínguez F, Luna Martín JJ, Pellicer A, Simón C . Implantation process of the human embryo. TWIN-Meeting Alpha-Andrology 2003, 4th Biennial Alpha Conference. 8th Meeting of Andrology in the 2000’s. September 2003; Antwerp, Belgium. Oral Presentation • Mercader A, Pérez I, Rodrigo L, Gómez E, Mateu E, Amaroroso B, Remohí J, Simón C , Pellicer A, Rubio C. Development of abnormal embryos in sequential culture versus co-culture systems. TWIN-Meeting Alpha-Andrology 2003, 4th Biennial Alpha Conference. 8th Meeting of Andrology in the 2000’s. September 2003; Antwerp, Belgium. Poster Presentation • Meseguer M, Garrido N, Martínez JA, Simón C , Pellicer A, Remohí J. Intracellular sperm and seminal plasma Ca+2 concentrations affect cryodamage susceptibility
119 after a cycle of freezing and thawing. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentatio • Meseguer M, Garrido N, Rodríguez M, Simón C , Pellicer A, Remohí J. Sperm glutathione antioxidant defense system protects from cryodamage after a cycles of freezing and thawing. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation
• Rodríguez M, Escudero E, Epifanio R, Garrido N, Meseguer M, Simón C . A mathematical equation to calculate the maximum pregnancy rate with a minimum risk for multiple pregnancies in patients undergoing IVF. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Troncoso C, Bosch E, Epifanio R, Simón C , Pellicer A, Remohí J. Endometrial thickness and serum oestradiol serum levels as predictors of success in oocyte donation. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Pehlivan T.S, Rodrigo L, Simón C , Remohí J, Pellicer A, Rubio C. Chromosomal abnormalities in day 3 embryos from servere oligozoospermic patients. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Garrido N, Meseguer M, Simón C , Pellicer A, Remohí J. Parameters affecting positive viral load after sperm wash on HIV seropositive patients. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Garrido N, Meseguer M, Rodríguez M, Simón C , Remohí J. PCR detection of Hepatitis C Virus (HCV) in washed sperm. Comparison of two different PCR- dependent methods for determining its presence. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Lima-Couy I, Cervero A, Bonilla-Musoles F, Remohí J, Pellicer A, Simón C . Endometrial leptin and leptin receptor expression in women with endometriosis. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Molina N. M, Bosch E, Troncoso C, Simón C , Pellicer A, Remohí J. Ectopic pregnancy in IVF with own versus donated oocytes. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Poster Presentation • Escudero E, Coelingh Bennink H.J.T, Boerrigter P.J, Bunchoten H, Pellicer A, Simón C. High dose of rec-LH overcomes the deleterious effect of high dose GnRH antagonist on embryonic implantation. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Oral Presentation • Gómez R, González M, Simón C , Remohí J, Pellicer A. Tyroxine hydroxylase (TH) downregulation in hyperstimulated ovaries reveals the dopamine agonist bromocriptine (Br2) as an effective and specific method to block increased vascular permeability (VP) in OHSS. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Oral Presentation • Gómez R, Lima L, Simón C , Pellicer A. Low-dose LH administration induces ovulation and prevents vascular hyperpermeability and VEGF expression in superovulated rats. 59th Annual Meeting of the American Society for Reproductive Medicine. October 2003; San Antonio, Texas, USA. Oral Presentation 2002 • Martín J, De Pablo J, Cervero A, Remohí J, Pellicer A, Simón C . Human endometrial cytoskeleton-associated ezrin family is up-regulated by progesterone during the menstrual cycle. In contrast no embryonic regulation was observed. 49th Annual Meeting of the Society for Gynecologic Investigation. March 2002; Los
120 Angeles, California, USA. Poster Presentation • Martín J, Domínguez F, Avila S, Pellicer A, Castrillo JL, Simón C . cDNA macroarray analysis of human endometrial tissue shows the differential expresión of GADD45A apoptosis-related gene in receptive endometria. 49th Annual Meeting of the Society for Gynecologic Investigation. March 2002; Los Angeles, California, USA. Poster Presentation • Riesewijk A, Martín J, Domínguez F, Van Os R, Pellicer A, Mosselman S, Simón C . Genes expressed in receptive versus pre-receptive human endometrium. 49th Annual Meeting of the Society for Gynecologic Investigation. March 2002; Los Angeles, California, USA. Poster Presentation • Domínguez F, Avila S, Martín J, Pellicer A, Castrillo J.L, Simón C . Differential gene expresión of cytokines, chemokines, growth factors and their receptors in RL95-2 and HEC-1-A cell lines. 49th Annual Meeting of the Society for Gynecologic Investigation. March 2002; Los Angeles, California, USA. Poster Presentation • Gomez R, Simón C , Remohí J, Pellicer A. The ovary as a source of gonadotrophin dependent vascular endotelial growth factor (VEGF) in an ovarian hyperstimulation syndrome (OHSS) animal model. 49th Annual Meeting of the Society for Gynecologic Investigation. March 2002; Los Angeles, California, USA. Poster Presentation • Miralles F, Muñoz EA, Scheffer B, Remohí J, Pellicer A, Simón C . Ovarian stimulation in intrauterine insemination with recombinant FSH. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Troncoso C, Bosch E, Rubio MC, Simón C , Remohí J, Pellicer A. The origin of biochemical pregnancies: lessons learned from preimplantation genetic diagnosis. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Muñoz EA, Muñoz M, Navarro J, Simón C , Remohí J, Pellicer A. Reproductive outcome of premature ovarian failure. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Garrido N, Meseguer M, Ruiz A, Simón C , Remohí JA, Pellicer A. Success in assisted reproduction cycles is not affected by the time that the sperm has been cryopreserved. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Gómez R, Simón C , Remohí JA, Pellicer A. Inhibition of luteal angiogenesis by blocking vascular endothelial growth factor receptor 2 as a specific approach to inhibit vascular permeability in an ovarian hyperstimulation syndrome animal model. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • Bosch E, Escudero E, Crespo J, Simón C , Remohí JA, Pellicer A. Follicular asynchrony in ovarian stimulation with GnRH antagonists. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • Escudero E, Rosal LP, Bosch E, Crespo J, Simón C , Remohí JA, Pellicer A. Has day 4 serum estradiol a predictive value in flare-up? 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • Scheffer B, García-Velasco JA, Scheffer R, Remohí J, Pellicer A, Simón C . Incidence of monozygotic twuinning is not related to zona pellucida micromanipulation or blastocyst stage transfer. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • ivan T, Rubio C, Rodrigo L, Remohí J, Pellicer A, Simón C . Chromosomal abnormalities in embryos from day 2 ICSI. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • Meseguer M, Garrido N, Garcia de Lomas J, Simón C , Remohí J, Pellicer A. HIV
121 and hepatitis C virus presence in washed semen: are they absent or present although non-infective? 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Poster Presentation • Crespo J, Escudero E, Bosch E, Gaytan J, Simón C , Remohí JA, Pellicer A. When to start the GnRH antagonist in IVF? Preliminary results. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Rubio C, Rodrigo L, Phelivan T, Simón C , Remohí JA, Pellicer A. Preimplantation genetic diagnosis in implantation failure and recurrent pregnancy loss. 18th Annual Meeting European Society of Human Reproduction and Embryology. July 2002; Vienna, Austria. Oral Presentation • Simón C . Leptin and leptin receptor in human endometrium and preimplantation embryos. Gordon Research Conference on Reproductive Tract Biology. June – July 2002; Connecticut College, New London, USA. Oral Presentation • Simón C . Ultrastructure of the human blastocyst. Gordon Research Conference on Reproductive Tract Biology. June – July 2002; Connecticut College, New London, USA. Oral Presentation • Bosch E, Valencia I, Crespo J, Simón C , Remohí J, Pellicer A. Relationship between serun LH and IVF outcome in cycles with a GnRH Antagonist (Cetrorelix). 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Escudero E, Mercader A, Troncoso C, Remohí J, Pellicer A, Simón C . Perinatologic results of infants born after an embryo coculture program with human epithelial endomtrial cells. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Garrido N, Meseguer M, Remohí J, Simón C , Pellicer A. Glutathione peroxidase expresión and activity correlates with sperm survival after thawing58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • García-Velasco JA, Corona J, Requena A, Remohí J, Simón C , Pellicer A. Should we operate ovarian endometriomas prior to IVF?. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Garrido N, Messeguer M, Gil-Salom M, Simón C , Remohí J, Pellicer A. Testicular sperm extraction (TESE) an intracytoplasmic sperm injection (ICSI) results in secondary azoospermic patients after chemotherapy. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Pehlivan T, Rubio C, Rodrigo L, Remohí J, Pellicer A, Simón C . Experience in preimplantation genetic diagnosis for recurrent IVF failure. A Two years follow-up study. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Troncoso C, Bosch E, Rubio C, Simón C , Remohí J, Pellicer A. The Origin of biochemical pregnancies: lessons learned from preimplantation genetic diagnosis (PGD). 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Valencia I, Bosch E, Simón C , Troncoso C, Remohí J, Pellicer A. Progesterone elevation during GnRH antagonists cycles in IVF adversely affects prefnancy and implantation rates. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Troncoso C, Escudero E, Gaytan J, Remohí J, Pellicer A, Simón C . Finding the ideal number of embryos to transfer on day 3 of development when there is a good embryo cohort?. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Bosch E, Albert C, Ruiz A, Simón C , Remohí J, Pellicer A. Oocyte and embryo quality in IVF cycles with GnRH antagonist vs GnRH agonist. 58th Annual Meeting of
122 the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Rosal LP, Bosch E, Escudero E, Remohí J, Pellicer A, Simón C . Day 3 embryo- assessment criteria validity for blastocyst transfer in Oocyte donation using a co- culture program. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Garrido N, Meseguer M, Remohí J, Simón C , Pellicer A. Success in assisted reproduction cycles with frozen sperm is not affected by the time that it has been cryopreserved. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Oral Presentation • Zuzuarregui JL, Meseguer M, Garrido N, Pellicer A, Simón C , Remohí J. Infectious diseases and genetic disorders found in the routinely screening in an ovum donation programme: experience from 10 years follow-up. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Poster Presentation • Rodrigo L, Rubio C, Simón C , Remohí J, Pellicer A, Gil-Salom M. Fluorescence “In Situ” hybridization (FISH) análisis of chromosomal abnormalities in testicular and epididymal spermatozoa. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Oral Presentation • Valencia I, Bosch E, Troncoso C, Simón C , Remohí J, Pellicer A. Premature luteinization during GnRH antagonists cycles in IVF adversely affects pregnancy and implantation rates. 58th Annual Meeting of the American Society for Reproductive Medicine. October 2002; Seattle, Washington, USA. Oral Presentation 2001 • Escobedo C, Martín J, Domínguez F, Valbuena D, Mercader A, O’Connor E, Pellicer A, Simón C . Embryonic regulation of cyclooxigenase-2 in human endometrial epithelial cells. 48th Annual Meeting of the Society for Gynecologic Investigation. March 2001; Toronto, Canada. Poster Presentation • Martín J, Avila S, Jiménez O, Pellicer A, Castrillo J.L, Simón C . Detection of novel genes associated to high versus low endometrial receptivity status. 48th Annual Meeting of the Society for Gynecologic Investigation. March 2001; Toronto, Canada. Poster Presentation • García-Velasco J.A, Simón C , Mor G, Arici A. Soluble Fas ligan is elevated in peritoneal fluid and serum of women with endometriosis. 48th Annual Meeting of the Society for Gynecologic Investigation. March 2001; Toronto, Canada. Poster Presentation • Gaytán J; Bellver J, Camargo F, Remohí J, Pellicer A, Simón C . Endometrial fluid aspiration at different days of the stimulated cycles does not affect IVF/ICSI outcome. II International Workshop on Human Implantation: Recent Advances & Clinical Aspects. May 2001; Madrid, Spain. Poster Presentation • Domínguez F, Dasi F, Remohí J, Pellicer A, Simón C . Embryonic regulation of rantes receptor (CCR5) and MCP-1 receptor (CCR2B) in cultured endometrial epithelial cells (EEC). II International Workshop on Human Implantation: Recent Advances & Clinical Aspects. May 2001; Madrid, Spain. Poster Presentation • Valbuena D, Martín J, Remohí J, Pellicer J, Simón C . High estradiol levels are deleterious to embryonic implantation due to a direct effect on the embryo development. II International Workshop on Human Implantation: Recent Advances & Clinical Aspects. May 2001; Madrid, Spain. Poster Presentation . • Rubio C, Gil-Salom M, Rodrigo L, Remohí J, Simón C , Pellicer A. Implications of sperm chromosome abnormalities on ICSI outcome. 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Poster Presentation • Isaza V, García-Velasco JA, Scheffer B, Landazabal A, Martinez-Salazar J, Requena A , Remohí J , Simón C . Does “coasting”affect the outcome in oocyte donation? 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Poster Presentation • Requena A, Isaza V, Caligara X, García-Velasco JA, Martinez-Salazar J, Landazabal
123 A, Remohí J, Simón C . Sharing oocytes from a single donor: predictors of discordant outcome. 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Poster Presentation • Meseguer M, Garrido N, Zuzuarregui JL, Romero JL, Simón C , Remohí J, Pellicer A. Is the use of donor spermatozoa a safe option? Infectious diseases and genetic disorders screening in a sperm donor population and a donor artificial insemination programme: experience from 10 years follow-up. 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Poster Presentation • Rodrigo L, Rubio C, Simón C , Remohí J, Pellicer A, Gil-Salom M. Incidence of chromosomal abnormalities in testicular and epididymal spermatozoa, analysed by fluorescence in-situ hybridization (FISH). 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Poster Presentation • Bosch E, Ruiz A, De los Santos MJ, Romero JL, Calderón G, Simón C , Remohí J, Pellicer A. Description of a measurable embryo quality index, and its relation to implantation and pregnancy rates. 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Oral Presentation • García-Velasco JA, Isaza V, Vidal C, Landazábal A, Remohí J, Simón C , Pellicer A. Human ovarian steroid secretion in vivo: effects of gonadotrophin-releasing hormone agonist versus antagonist (cetrorelix). 17th Annual Meeting European Society of Human Reproduction and Embryology. July 2001; Lausanne, Switzerland. Oral Presentation • Meseguer M, Garrido N, Romero J, Remohí J, Simón C , Pellicer A. Parameters affecting sperm survival after thawing in long-term frozen storage. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Caligara C, Navarro J, Camargo F, Simón C , Pellicer A, Remohí J. Oocyte retrieval rate through repeated identical controlled ovarian stimulation cycles in donors. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Isaza V, García-Velasco J, Martinez-Salazar J, Requena A, Landazabal A, Simón C . Does measurement of ovarian stromal blood flow by color Doppler predict IVF outcome?. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Camargo F, Gaytan J, Caligara C, Simón C , Pellicer A, Remohí J. Impact of ultrasound diagnosis of adenomyosis on recipients of sibling oocytes. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Vargas-Chavarria G, Caligara C, Bosch E, Simón C , Remohí J, Pellicer A. The use of long-acting forms of gonadotropin-releasing hormone analogs (GnRHa Depot) increase miscarriage rates in oocyte donation cycles. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Escriba MJ, Valbuena D, Sánchez E, Remohí J, Pellicer A, Simón C . Diploid rescue from tripronucleated human embryos. A new tool for embryo research. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Vargas-Chavarría G, Meseguer M, Garrigo N, Simón C , Remohí J, Pellicer A. Timing does not influence outcomes in double intrauterine insemination. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Mercader A, Gamiz P, De los Santos M, Remohí J, Pellicer A, Simón C . Sex ratio after day 2, day 3 or blastocyst transfer. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Poster Presentation • Domínguez F, Avila S, Martin J, Pellicer A, Castrillo J, Simón C . Differential gene
124 expression of cytokines, chemokines, growth factors and their receptors in receptive versus non-receptive human endometrium. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Oral Presentation • García-Velasco JA, Martínez-Salazar J, Isaza V, Landazabal A, Requena A, Simón C. Does ultrasound guidance at embryo transfers improve pregnancy rates in oocyte recipients? 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Oral Presentation • Valbuena D, Martín JC, De Pablo JL, Remohí J, Pellicer A, Simón C . Increasing levels of estradiol are deleterious to embryonic implantation due mainly to a direct effect on the embryo. 57th Annual Meeting of the American Society for Reproductive Medicine. October 2001; Orlando, Florida, USA. Oral Presentation • Isaza V, Arbues J, García-Velasco J.A, Requena A, Martínez-Salazar J, Landazábal A, Villasante A, Scheffer B, Remohí J, Pellicer A, Simón C . Nafarelin versus triptorelin for in-vitro fertilization: a randomized study. IV Congress of the European Society of Gynaecology. October 2001; Barcelona, Spain. Poster Presentation
• Scheffer B, Isaza V, García-Velasco J.A, Requena A, Martínez-Salazar J, Landazábal A, Villasante A, Remohí J, Pellicer A, Simón C . Monozygotic twinning: a phenomenon independent of assisted reproductive treatment modalities. IV Congress of the European Society of Gynaecology. October 2001; Barcelona, Spain. Poster Presentation. 2000 • Garrido N, Krussel J, O’Connor J, Simón C , Pellicer A. Expression, production and secretion of vascular endothelial growth factor (VEGF) and Interleukin-6 (IL-6) by granulosa cells in women with endometriosis. 47th Annual Meeting of the Society for Gynecologic Investigation. March 2000; Chicago, Illinois, USA. Poster Presentation • Meseguer M, Simón C , Caballero-Campo P, Martín J, Pellicer A, Aplin J. MUC1 is down-regulated by TGF-PUC1 is down-regulated by TGF- Pellicer A, Aplin J. f vascular endothelial growth factor (VEGF) aChicago, Illinois, USA. Poster Presentation • Valbuena K, Jasper M, Galán A, Pellicer A, Simón C . High estradiol levels alter embryonic adhesion on endometrial epithelial cells (EEC). 47th Annual Meeting of the Society for Gynecologic Investigation. March 2000; Chicago, Illinois, USA. Poster Presentation • Meseguer M, Simón C , Wreschner D, Hey N, Aplin J. The alternatively spliced MUC1 isoform SEC is associated with the apical surface of human endometrial epithelial cells. 47th Annual Meeting of the Society for Gynecologic Investigation. March 2000; Chicago, Illinois, USA. Poster Presentation • Martín J, Jasper M, Valbuena D, Meseguer M, Simón C . Absence of moesin expression in cultured endometrial-derived cells with more adhesive properties for blastocysts. 47th Annual Meeting of the Society for Gynecologic Investigation. March 2000; Chicago, Illinois, USA. Poster Presentation • Domínguez F, Caballero-Campo P, Meseguer M, Pellicer A, Simón C . Hormonal and embryonic regulation of chemokines IL-8, MCP-1, RANTES and their receptors CXCR1,CCR2B and CCR5 in human endometrium. 47th Annual Meeting of the Society for Gynecologic Investigation. March 2000; Chicago, Illinois, USA. Poster Presentation • De los Santos MJ, Mercader A, Galán A, Prados N, Remohí J, Pellicer A, Simón C . The predictive value of three or more 8-cell embryos on pregnancy rate in co-culture system. International Symposium on Art and the Human Blastocyst. March – April 2000; Dana Point, California, USA. Oral Presentation • Rubio C, Vidal F, Mínguez Y, Giménez C, Romero J, Egozcue J, Remohí J, Pellicer A, Simón C . Preimplantation Genetics Diagnosis (PGD): a powerful tool in female and male carriers of balanced translocations. 10th International Conference on Prenatal Diagnosis And Therapy. June 2000; Barcelona, Spain. Oral Presentation
125 • Garrido N, Krüssel J.S, Remohí J, Simón C , Pellicer A. Progesterone production and 3P hydroxsteroid dehydrogenase (3P HSD) expression in granulosa cells from women with endometriosis. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • Ibérico G, Serra V, Rodríguez M, Simón C , Pellicer A, Remohí J. Modified early transvaginal technique of embryo reduction in multifetal pregnancies resulting from assisted reproduction techniques. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation
• Muñoz E, Cuneo S,Ferro J, Vidal C, Pellicer A, Simón C , Remohí J. Intravenous albumin in the prevention of ovarian hyperstimulation syndrome. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • García-Velasco J.A, Isaza V, Requena A, Martínez-Salazar J, Landazábal A, Remohí J, Pellicer A, Simón C . Stop protocol versus high doses of gonadotrophins in low responder IVF patients: a prospective, randomized, controlled trial. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • Camargo F, Crespo J, Cuneo S, Caligara C, Simón C , Pellicer A, Remohí J. Implications of adenomyosis in the infertile patient. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • Isaza V, Requena A, García-Velasco J.A, Anarte C, Landazabal A, Martínez-Salazar J, Remohí J, Pellicer A, Simón C . Urinary-FSH vs recombinant FSH in patients undergoing intrauterine inseminations: a prospective study. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • Rubio C, Vidal F, Mínguez Y, Romero J, Giménez C, Egozcue J, Remohí J, Pellicer A, Simón C . High incidence of chromosomal abnormalities in preimplantation embryos from recurrent spontaneous abortion patients. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Oral Presentation • Gil-Salom M, Rubio C, Mínguez Y, Vidal C, Simón C , Remohí J, Pellicer A. Correlation between the severity of oligozoospermia and the incidence of sperm chromosomal abnormalities in a risk population. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Oral Presentation • Caligara C, Vargas G, Cuneo S, Rodríguez M, Simón C , Pellicer A, Remohí J. Does repeated controlled ovarian hyperstimulation affect oocyte retrieval rate in donors?. 16th Annual Meeting European Society of Human Reproduction and Embriology. June 2000; Bologna, Italy. Poster Presentation • Avila S, Martín J, Simón C , Jiménez O, Mayor P, Martínez-conde A, Castrillo JL. Analisis molecular del mecanismo de implantación de embriones humanos: clonaje mediante DDRT-PCR y “cDNA microarrays” de genes especificamente expresados en células de endometrio receptivo. Genética y Biomedicina molecular 2000. October 2000; Monterrey, Mexico. Poster Presentation • Domínguez F, Galán A, Mercader A, Garrido N, Pellicer A, Simón C . Identification of Chemokine receptors for IL-8, SDF-1, RANTES and MCP-1 in Human blastocysts and cultured endometrial epithelial cells (EEC). 56th Annual Meeting of the American Society for Reproductive Medicine. October 2000; San Diego, California, USA. Poster Presentation • Mercader A, Galán A, De los Santos M.J, Remohí J, Pellicer A, Simón C . Have day 3 embryo morphology a predictive value in blastocyst formation. 56th Annual Meeting of the American Society for Reproductive Medicine. October 2000; San Diego, California, USA. Oral Presentation • Martín J, Avila S, Giménez O, Pellicer A, Castrillo J.L, Simón C . Differential gene expression in high versus low endometrial receptivity status. 56th Annual Meeting of
126 the American Society for Reproductive Medicine. October 2000; San Diego, California, USA. Oral Presentation • Requena A, García-Velasco J.A, Anarte C, Remohí J, Pellicer A, Simón C . Safety of long term oral estradiol administration in an oocyte donation program. 56th Annual Meeting of the American Society for Reproductive Medicine. October 2000; San Diego, California, USA. Poster Presentation • González R.R, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Simón C . Expression of leptin and its receptor at protein and mRNA levels in the human endometrium and endometrial epithelial cells (EEC) co-cultured with human embryos. Effects of interleukin-1Pxpression of leptin and its receptor at protein and mRNA levels in the human endometrium and endometrial epithelial cells (EEC) co- cultured with human embryos. Effects of interleuk 1999 • Simón C , Rubio C, Vidal F, Mínguez Y, Giménez C, Egozcue J, Remohí J, Pellicer A. In Vitro Fertilization (IVF) and preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos. 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Albert C, Garrido N, Mercader A, Remohi J, Simón C , Pellicer A. The Endometrium as the origin of ovarian hyperstimulation syndrome (OHSS). 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Garrido N, Albert C, O’Connor J.E, Remohí J, Simón C , Pellicer A. The role of leukocytes in the secretion of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) of women at risk of ovarian hyperstimulation syndrome (OHSS). 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Meseguer M, Caballero-Campo P, O’Connor J.E, Galán A, Martín J.C, Remohí J, Pellicer A, Simón C .Embryonic regulation of MUC1 in human uterine epithelial cells. 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Caballero-Campo P, Comoma J, Meseguer M, César J, Mercader A, Remohí J, Pellicer A, Simón C . Chemokines interleukin-8 (IL-8), and monocyte Chemotactic protein-1 (MCP-1) mRNA regulation in cultured human endometrial epithelial cells (EEC) by the human embryo. 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Martín J.C, Meseguer M, Caballero-Campo P, Herrer R, Remohí J, Pellicer A, Simón C . Expression of Ezrin, a membrane-cytoskeletal linker, in human endometrial epithelial cells. 46th Annual Meeting of the Society for Gynecologic Investigation. March 1999; Atlanta, Georgia, USA. Oral Presentation • Galán A, Herrer R, Mercader A, Meseguer M, Remohí J, Pellicer A and Simón C . Embryonic regulation of endometrial cell apoptosis in the adhesion phase of human implantation. International Workshop on Human Implantation: Recent Advances & Clinical Aspects. March 1999; Valencia, Spain. Poster Presentation • Martín J. C, O´Connor J.E. Mesegure M, Galán A, Caballero-Campo P, Jasper M, Remohí J, Pellicer A, Simón C . Embryonic regulation of ezrin, a membrane- cytoskeletal linker, in human endometrial epithelial cells. International Workshop on Human Implantation: Recent Advances & Clinical Aspects. March 1999; Valencia, Spain. Poster Presentation • Moreno C, Mercader A, Ruiz A, Remohí J, Pellicer A, Simón C . Desarrollo preimplantatorio de embriones ICSI. VI Congreso de la Federación Latinoamericana de Sociedades de Esterilidad y fertilidad. I Congreso panameño de infertilidad y endoscopia ginecológica. II Foro Latinoamericano de Reproducción Humana. March 1999; Panama. Oral Presentation • Mercader A, Herrer R, Galán A, Valbuena D, Remohí J, Simón C , Pellicer A. Embryonic development in epithelial endometrial cells co-culture system versus sequential culture medium of embryos from patients with repeated failures of
127 implantation. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Oral Presentation • Garrido N, Albert C, Mercader A, O´Connor J.E, Remohí J, Simón C , Pellicer A. Leukocyte subpopulations in ovulatory follicles in patients with endometriosis. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Poster Presentation • Mercader A, Galan A, Herrer R, Albert C, Remohí J, Simón C , Pellicer A. Is assisted hatching justified? An analysis of spontaneous hatching in a human epithelial endometrial co-culture system. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Poster Presentation • Landazábal A, Díaz I, Valbuen a D, Muñoz E, Remohí J, Simón C , Pellicer A. Endometriosis and in-vitro fertilization: a meta-analysis. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Poster Presentation • Díaz I, Navarro J, Vergara F, Alvarez J.C, Simón C , Pellicer A, Remohí J. Effect of laparoscopic myomectomy in in-vitro fertilization (IVF) outcome in patients with failed cycles prior to surgery. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Oral Presentation • Caballero-Campo P, Meseguer M, Martín J.C, Coloma J, O´Connor J.E, Remohi J, Pellicer A and Simón C . Embryonic regulation of MCP-1 in human endometrial epithelial cells. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Oral Presentation • Vergara F, Andreu S, Diaz I, Alvarez J.C, Rodriguez M, Serra V, Simón C , Pellicer A, Remohí J. Comparative study of obstetric and perinatal outcome in an oocyte donation programme. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Oral Presentation • Diaz I, Navarro J, Simón C , Pellicer A, Remohí J. Impact of stages III-IV of endometriosis on the outcome in recipients of oocytes from the same donor: matched case-control study. 15th Annual Meeting European Society of Human Reproduction and Embryology. June 1999; Tours, France. Oral Presentation • Vidal F, Blanco J, Rubio C, Giménez C, Simón C , Martínez M.C, Mínguez Y, Santaló J, Pellicer A, Remohí J, Egozcue J. Segregation analysis in the spermatozoa and preimplantation genetic diagnosis in the embryos from a patient 46, XY (7;Y) (p11; q13). Second European Cytogenetics Conference. July 1999; Vienna, Austria. Poster Presentation • Gonzalez R.R, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Simón C . Dinamics of leptin secretion by human blastocyst and endometrial epithelial. Conjoint Annual Meeting American Society for Reproductive Medicine and Canadian Fertility and Andrology Society. September 1999; Toronto Canadá. Poster Presentation • Meseguer M, Caballero-Campo P, Martin J, Galan A, Remohí J, Pellicer A, Simón C . Hormonal regulation “In vivo” of Muc1 in Human endometrium. Conjoint Annual Meeting American Society for Reproductive Medicine and Canadian Fertility and Andrology Society. September 1999; Toronto Canadá. Poster Presentation • Rubio C, Pellicer A, Vidal F, Mínguez Y, Romero J, Giménez C, Remohí J, Simón C . Impact of Chromosome Abnormalities In Human Embryo Development. Conjoint Annual Meeting American Society for Reproductive Medicine and Canadian Fertility and Andrology Society. September 1999; Toronto Canadá. Oral Presentation • Albert C, Garrido N, Mercader A, Remohí J, Simón C , Pellicer A. The Role Of The Endothelium In The Ovarian Hyperestimulation Syndrome (OHSS). Conjoint Annual Meeting American Society for Reproductive Medicine and Canadian Fertility and Andrology Society. September 1999; Toronto Canadá. Poster Presentation • Gonzalez R.R, Devoto L, Caballero-Campo P, Mercader A, Campana A, Simón C , Bishof P. Leptina: ¿Un factor regulador de la implantación?. XVI Reunión de la Asociación Latinoamericana de Investigadores en Reproducción Humana. September 1999; Marbella, Chile. Poster Presentation • Caballero-Campo P,Meseguer M, Martín J.C, Domínguez F, Coloma J, Simón C .
128 Regulación embrionaria del RNAm de la integrina-b3 en cultivos de células del epitelio endometrial (CEE) humano. XVI Reunión de la Asociación Latinoamericana de Investigadores en Reproducción Humana. September 1999; Marbella, Chile. Poster Presentation • Vidal F, Blanco J, Rubio M.C, Aran B, Egozcue S, Alcolea R, Simón C , Veiga A, Minguez Y, Remohí J, Pellicer A, Barri P, Vendrell J.M, Marina S, Egozcue J. Screening for chromosome abnormalities in spermatozoa from infertile men in a clinical setting. Annual Meeting of the American Society of Human Genetics. October 1999; San Francisco, USA. Poster Presentation 1998 • Caballero P, Bernal A, Mercader A, O´connor JE Coloma J, Remohi J, Pellicer A, Simón C . Embryonic regulation of IL-8 production and secretion in human endometrial epithelial cells. 45th Annual Meeting of the Society for Gynecologic Investigation (SGI). March 1998; Atlanta, USA. Oral Presentation • Albert C, Mercader A, Herrer R, J, Remohi J, Simón C , Pellicer A. Serum and Follicular Fluid (FF) vascular endothelial growth factor (VEGF) and Interleukin-6 levels in women at risk to develop ovarian hyperstimulation syndrome (OHSS). 45th Annual Meeting of the Society for Gynecologic Investigation (SGI). March 1998; Atlanta, USA. Oral Presentation • Galán A, O´Connor J.E, Mercader A, Simón C . Embryonic regulation of apoptosis in endometrial epithelium. International Symposium on Reproductive Medicine Co- Sponsored by ASRM ESHRE-IVI. State of the Art of Human implantation.Basic and Clinical Aspects. May 1998, Madrid, Spain. Oral Presentation • Moreno C, Gaitán P, Alvarez J, Molero D, Remohí J, Pellicer A, Simón C . Reproductive outcome of ovum donation recipients acording to the source of oocytes. International Symposium on Reproductive Medicine Co-Sponsored by ASRM ESHRE-IVI. State of the Art of Human implantation.Basic and Clinical Aspects. May 1998, Madrid, Spain. Oral Presentation • Moreno C, Ruiz A, Simón C , Pellicer A, Remohí J. ICSI as a routine indication in low responder patients. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Oral Presentation • Requena A, Neuspiller F, Cobo A.C., Aragonés M, Ruíz A, Remohí J, Simón C , Pellicer A. The potential use of in-vitro maturation of germinal vesicle-stage oocytes in low responders. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Oral Presentation • Rubio C, Blanco J, Mínguez Y, Vidal F, Remohí J, Egozcue J, Simón C . Implications of sperm chromosomal abnormalities in habitual abortion. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Oral Presentation • Raga F, Casañ E.M, Ruiz A, Remohí J, Simón C , Polan M.L, Pellicer A. Gonadotrophin-releasing hormone agonist administered throughout the luteal phase and early pregnancy increases fecundity in IVF-embryo transfer patients. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Oral Presentation • Meseguer M, Gaitán P, Mercader A, Caballero P, Remohí J, Pellicer A, Simón C . Hormonal regulation “in vivo” of MUC1 in mock cycles from patients undergoing oocyte donation. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Oral Presentation • Requena A, Neuspiller F, Cobo A.C, Aragonés M, Rubio C, Remohí J, Simón C , Pellicer A. Endocrine changes in women undergoing follicular aspiration for in-vitro culture of immature oocytes. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Cobo A, Aragonés M, Requena A, Neuspiller F, Romero J, Mínguez Y, Simón C , Remohí J, Pellicer A. Analysis of different parameters affecting outcome in in-vitro maturation of human oocytes. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Moreno C, Mercader A, Ruiz A, Herrer R, Valbuena D, Remohí J, Pellicer A, Simón
129 C. Preimplantation development outcome of embryos after in-vitro fertilization is superior to that after intracytoplasmic sperm injection. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Vergara F, Andreu S, Díaz I, Neuspiller F, Ardiles G, Simón C , Pellicer A, Remohí J. Obstetric and perinatal outcome in an oocyte donation programe. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Ardiles G, Neuspiller F, Vergara F, Díaz I, Simón C , Pellicer A, Remohí J. Seven years of experience in an oocyte donation programme. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Gaitán P, Moreno C, Ruiz A, Alvarez J, Remohí J, Simón C , Pellicer A. Predictive value of embryonic characteristics before cryopreservation on the outcome after thawing. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Neuspiller F, Roscizsewski V, Ardiles G, Dolz M, Abad-Velasco L, Pellicer A, Simón C, Remohí J, Bonilla-Musoles F. Three dimensional rendering ultrasound of the endometrium: evaluation with cavity distension medium. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Valbuena D, Albert C, Garrido N, Remohí J, Simón C , Pellicer A. Cytokines in older patients undergoing IVF: the relationship to the response to controlled ovarian hyperstimulation. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Remohí J, Neuspiller F, Ardiles A, Ballesteros A, Landeras J, Requena A, Simón C , Pellicer A. A new technique for submucous myoma resectoscopy. Preliminary report. 14th Annual Meeting. European Society of Human Reproduction and Embryology. June, 1998; Göteborg, Sweden. Poster Presentation • Kohen P, Caballero P, Castro O, Castro A, Vega M, Simón C , Carvallo P, Devoto L. Análisis de la expresión del receptor tipo I de Interleukina-1 y su antagonista en cuerpo lúteo humano. IX Reunión anual de la Sociedad chilena de reproducción y desarrollo. I Congreso de la Sociedad Chilena de Fertilidad. August 1998; La Serena, Chile. Oral Presentation • Caballero-Campo P, Mercader A, Galán A, Meseguer M, Martín JC, Coloma J, O ´Connor JE, Pellicer A y Simón C . El co-cultivo con células del epitelio endometrial como modelo in vitro para estudios de regulación embrionaria de moléculas endometriales en la especie humana. IX Reunión anual de la Sociedad chilena de reproducción y desarrollo. I Congreso de la Sociedad Chilena de Fertilidad. August 1998; La Serena, Chile. Oral Presentation • Navarro J, Albert C, Mercader A, Remohí J, Simón C , Pellicer A. The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production. 54th Annual Meeting of the American Fertility Society for Reproductive Medicine (ASRM) & 16th World Congress on Fertility and Sterility. October 1998; San Francisco, California, USA. Oral Presentation • Kohen P, Castro A, Castro O, Carvallo P, Caballero P, Simón C , Devoto L. Interleukin 1b (IL-1b) is a modulator of human luteal steroidogenesis54th Annual Meeting of the American Fertility Society for Reproductive Medicine (ASRM) & 16th World Congress on Fertility and Sterility. October 1998; San Francisco, California, USA. Oral Presentation • Simón C , Mercader A, Garcia-Velasco J, Valbuena D, Herrer R, Moreno C, Pellicer A. Coculture of embryos with autologous human endometrial epithelial cells and transfer at blastocyst stage increases implantation rates in patients with repeated failures of Implantation. 54th Annual Meeting of the American Fertility Society for Reproductive Medicine (ASRM) & 16th World Congress on Fertility and Sterility. October 1998; San Francisco, California, USA. Oral Presentation • Garcia-Velasco J.A., Simón C , Ardiles G, Neuspiller F, Remohí J, Nikas G.
130 Assessment of endometrial response to HRT usig the detection of pinapods in women with endometriosis undergoing oocyte donation. 54th Annual Meeting of the American Fertility Society for Reproductive Medicine (ASRM) & 16th World Congress on Fertility and Sterility. October 1998; San Francisco, California, USA. Poster Presentation 1997 • Simón C , Gimeno M.J, Mercader A, O`Connor E, Polan M.L and Pellicer A. Embryonic regulation of β3-integrin in human endometrial epithelial cells is mediated by IL-1. 44th Annual Meeting of the Society for Gynecologic Investigation (SGI). March 1997; San Diego, USA. Oral Presentation • Pellicer A, Garcia Velasco J.A, Valbuena D, Remohí J, Simón C . Gonadotropin suppression and oocyte quality. Human Oocytes: from physiology to IVF. April 1997; Bologna, Italy. Oral Presentation • Asch R.H., Gaytan P, Ruiz A, Simón C , Remohí J and Pellicer A. Young poor responders do not have a decreased success with ART. 10th World Congress on In Vitro Fertilitation & Assisted Reproduction. May 1997; Vancouver, Canada. Oral Presentation • Gaitan P, Simón C , Ruiz A ,Remohí J, Asch R.H. and Pellicer A. The importance of embryo selection in the success of ICSI. 10th World Congress on In Vitro Fertilitation & Assisted Reproduction. May 1997; Vancouver, Canada. Oral Presentation • Kruessel JS, Huang HY, Simón C ., Behr B., Kloodt A.R. Wen Y., Bielfeld P., Polan M.L. Single blastomeres obtained from human preimplantation embryos express different amounts of mRNA for various genes: implications for future applications of this method for preimplantation diagnosis. 13th Annual Meeting of the ESHRE. June 1997; Edinburgh, UK. Oral Presentation • Nikas G., Garcia Velasco J., Pellicer A. and Simón C . Assessment of uterine receptivity and timing of embryo transfer using the detection of pinopods. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Oral Presentation • Ardiles G., Levy M., Yalil S., Newspiller F., Remohí J., Simón C . and Pellicer A. Lack of correlation of serum oestradiol concentrations and endometrial thickness with endometrial receptivity in an oocyte donation programme. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Oral Presentation • Simón C ., Mercader A., Moreno C., Gaitan P., Grimalt L., Remohí J. and Pellicer A. Instituto Valenciano de Infertilidad. Co-culture of embryos on homologous human endometrial epithelial cells in patients with repeated implantation failures. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Oral Presentation • Simón C ., García Velasco J., Valbuena D., Crespo J., Peinado J.A., Remohí J. and Pellicer A. Lower oestradiol concentrations during the preimplantation period in high- responder patients, following and FSH step-down regimen, increase pregnancy rates. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Poster Presentation • Mínguez Y., Rubio C., Romero J.L.L., Gil-Salom M., Simón C ., Remohí J. and Pellicer A. Effect of endometriosis on ICSI results in couples with male factor infertility. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Oral Presentation • Zuzuarregui J. L., García-Velasco J. A., Landeras J., Simón C ., Remohí J. and Pellicer A. HIV prevalence in infertile patients. 13th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1997; Edinburgh, UK. Oral Presentation • Albert C, Mercader A, Herrer R, Bernal A, Remohí J, Simón C , Pellicer A. Ovarian hiperstimulation syndrome: the role of hCG in the production of vascular endothelial growth factor and interleukin-6. International Workshop on Paracrine Mechanisms in Female Reproduction. June 1997; Seville, Spain. Oral Presentation • Bauset C, Valbuena D, Remohí J, Simón C , Pellicer A. Hormone environment in
131 follicles of patients with endometriosis during controlled ovarian stimulation. International Workshop on Paracrine Mechanisms in Female Reproduction. June 1997; Seville, Spain. Oral Presentation • Simón C , Valbuena D. Rol del sistema de la IL-1 en la implantación. VIII Reunión anual de la Sociedad Chilena de Reproducción y Desarrollo. August 1997; La Serena, Chile. Oral Presentation • Vidal F, Rubio C, Simón C , Gimenez C, Pellicer A, Santaló J., Egozcue J. Preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy loss. Second International Symposium on Preimplantation Genetics. September 1997; Chicago, USA. Oral Presentation • Kruessel J, Simón C , Rubio M. C, Huang H.Y, Wen Y, Kloodt A.R, Bielfeld P, Polan M.L. Expression of Interleukin-1 (IL-1) system messenger ribonucleic acids (mRNAs) in single blastomeres from human preimplantation embryos. 53th Annual Meeting of the American Society for Reproductive Medicine. October 1997; Cincinnati, USA. Oral Presentation • Raga F, Bauset C, Bonilla-Musoles F, Casañ E.M, Remohí J, Simón C , Pellicer A. Reproductive impact of congenital mullerian anomalies on women willing to conceive. 53th Annual Meeting of the American Society for Reproductive Medicine. October 1997; Cincinnati, USA. Oral Presentation • Simón C , Landeras J, Zuzuarregi J.L, Remohí J, Pellicer A. Early embryonic losses after oocyte donation. 53th Annual Meeting of the American Society for Reproductive Medicine. October 1997; Cincinnati, USA. Poster Presentation • Simón C , Rubio C, Vidal F, Moreno C, Parrilla J, Pellicer A. Recurrent pregnancy loss. Maternal or/and embryonic fault. Serono Colloquia Australasia “Genes and Environment in Human Reproductive Disorders”. November – December 1997; Adelaide, Australia. Oral Presentation 1996 • Blanco J, Simón C , Rubio C, Egozcue J, Vidal F. Incidence of disomic sperm nuclei in a 47, XYY male assessed by fluorescence in situ hybridization (FISH). 28th Meeting of the European Society for Human Genetics (ESHG). April 1996; London, UK. Poster Presentation • Mercader A, Francés A, Gimeno MJ, Remohí J, Pellicer A, Simón C . Serum concentrations and endometrial interleukin- 1 system microenvironment of the human embryo at the apposition phase under phisiological and supraphisiological steroid levels conditions. 12th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1996; Maastricht, The Netherlands. Oral Presentation • Guanes P.P, Gallardo E, Levy M, Simón C , Remohí J and Pellicer A. Effect of age on sperm fertilizing potential: oocyte donation as a model. 12th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1996; Maastricht, The Netherlands. Oral Presentation • Blanco J, Rubio C, Simón C , Egozcue J and Vidal F. A fluorescent in-situ hybridization study of the spermatogenic process and sperm production in a 47, XYY and a 47,XXY/46, XY infertile male: implications for ICSI. 12th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1996; Maastricht, The Netherlands. Poster Presentation • Guanes P.P, Gartner B, Gallardo E, Simón C , Remohí J and Pellicer A. Age does not affect uterine resistance to vascular flow in patients undergoing oocyte donation. 12th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1996; Maastricht, The Netherlands. Poster Presentation • Gallardo E, Gutiérrez A, Bauset C, Simón C , Remohí J, Pellicer A. Fertilización espermática. La edad como factor de influencia y la donación de ovocitos como modelo. XXXIII Reunión anual de la Asociación Mexicana de Medicina de la Reproduccion. July 1996; Puerto Vallarta, México. Oral Presentation. • Gutiérrez GA, Gallardo E, Simón C , Remohí J, Pellicer A. Incidencia del embarazo ectópico en reproducción asistida. XXXIII Reunión anual de la Asociación Mexicana
132 de Medicina de la Reproduccion. July 1996; Puerto Vallarta, México. Oral Presentation. • Gutiérrez A, Gallardo E, Simón C , Remohí J, Pellicer A. Niveles séricos de estradiol en receptoras de ovocitos. Su influencia sobre la capacidad de implantación en donación de ovocitos. XXXIII Reunión anual de la Asociación Mexicana de Medicina de la Reproduccion. July 1996; Puerto Vallarta, México. Oral Presentation. • Gutiérrez A, Simón C , Remohí J, Pellicer A. Inyección intracitoplasmática de espermatozoides (ICSI) con espermatozoides testiculares y epididimarios en fresco y congelados. XXXIII Reunión anual de la Asociación Mexicana de Medicina de la Reproduccion. July 1996; Puerto Vallarta, México. Oral Presentation. • Simón C , Gimeno M.J, Mercader A, O`Connor E, Polan M.L and Pellicer A. Embryonic regulation of integrins P , P and P1 on human endometrial epithelial cells. 52th Annual Meeting of the American Society for Reproductive Medicine. November 1996; Boston, USA. Oral Presentation • Kruessel J.S, Simón C , Bielfeld P, Wen Y, Batey D.W, Sha S, Huang H.Y, Polan M.L. Interleukin-1 β (IL-1 β) and interleukin-1 receptor antagonist (IL-1ra) messenger ribonucleic acid (mRNA) expression in different parts of the human fallopian tube throughout the menstrual cycle: possible implication for early embryonic development. 52th Annual Meeting of the American Society for Reproductive Medicine. November 1996; Boston, USA. Oral Presentation • Castro O, Kohen P, Castro A, Troncoso JL, Simón C , Vega M, Devoto L. Rol de interleukina- 1PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP PPPPPPPPPPPPPPPOral Presentation 1995 • De los Santos M.J, Francés A, Mercader A, Ruiz A, Remohí J, Pellicer A, Simón C Immunohistochemical localization of the interleukin-1 system in the human oocyte and embryo during embryonic development. 11th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1995; Hamburg, Germany. Oral Presentation • Cano F, Pellicer A, Gutierrez A, Remohí J, Simón C . Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal- responder patients. 11th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June – July 1995; Hamburg, Germany. Oral Presentation • Gallardo E, Guanes PP, Simón C , Gil-Salom M, Rubio C, Mínguez Y, Remohí J and Pellicer A. Comparison of fertilization capability of spermatozoa from ejaculate, epididimal biopsy and testicular biopsy using ICSI technique in severe male factor infertility. 15th World Congress on Fertility and Sterility. September 1995; Montpellier, France. Oral Presentation • Guanes PP, Mendoza R, Gallardo E, Rodriguez-Escudero F, Remohí J, Neyro JL, Pellicer A, Simón C . Immunosupresion by corticoids does not improve implantation rates in patients with previous IVF failures. 15th World Congress on Fertility and Sterility. September 1995; Montpellier, France. Oral Presentation • Valbuena D., Mercader A, De los Santos MJ, Remohí J, Pellicer A and Simón C . Clinical evidence for a detrimental effect on uterine receptivity of high Serum oestradiol levels troughout the preimplantation period in high versus normal responder patients. 15th World Congress on Fertility and Sterility. September 1995; Montpellier, France. Oral Presentation • Gallardo E, Guanes PP, Cano F, Simón C , Remohí J and Pellicer. Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. 15th World Congress on Fertility and Sterility. September 1995; Montpellier, France. Oral Presentation • Minguez Y, Rubio C, Simón C , Remohí J, Gil- Salom M, Pellicer A. Efficacy of intracytoplasmic testicular sperm injection in obstructive azoospermia. 51th Annual Meeting of the American Society for Reproductive Medicine. October 1995; Seattle, USA. Poster Presentation
133 • Simón C , Mercader A, Francés A, De los Santos M.J, Pellicer A, Remohí J. Effects of estradiol and progesterone on serum and endometrial IL-1a, IL-1b and IL-1ra levels in patients undergoing oocyte donation. 51th Annual Meeting of the American Society for Reproductive Medicine. October 1995; Seattle, USA. Poster Presentation 1994 • Piquette G.N., Tilly J.L, Prichard L.E, Simón C , Polan M.L. A non-radioactive method for the detection of apoptosis. 41th Annual Meeting of the Society for Gynecologic Investigation (SGI). March 1994; Chicago, USA. Poster Presentation. • Simón C , Tsafriri A, Dang W, Polan M.L. Interleukin-1 receptor antagonist (IL-1ra) supresses hCG-induced ovulation in the rat. 41th Annual Meeting of the Society for Gynecologic Investigation (SGI). March 1994; Chicago, USA. Poster Presentation. • Piquette GN, Simón C . Detection of apoptosis in human ovarian follicles. Annual Meeeting of the Endocrine Society. June 1994; Los Angeles, USA. Poster Presentation. • Gutiérrez A, Cano F, Ruiz A, Simón C , Pellicer A, Remohí J. Does ovarian function influence the outcome of oocyte donation? 10th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1994; Brussels, Belgium. Oral presentation • Cano A, Simón C , Ruiz A, Gutiérrez A, Tarín J, Remohí J, Pellicer A. The use of growth hormone-releasing factor in IVF: possible effects on quality of the human oocytes. 10th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1994; Brussels, Belgium. Oral presentation • Simón C , Francés A, Pellicer A, Polan M.L. Interleukin-1 receptor antagonist (IL-1ra) localization in human endometrium throughout the menstrual cycle. 50th Annual Meeting of the American Fertility Society (AFS). November 1994; San Antonio, Texas, USA. Oral presentation • Remohí J, Gutiérrez A, Simón C , Cano F, Tarín J, Pellicer A. Long estradiol replacement regimen in oocyte donation program. 50th Annual Meeting of the American Fertility Society (AFS). November 1994; San Antonio, Texas, USA. Oral presentation 1993 • Simón C , El-Danasouri I, Piquette G.N, Francés A, Westphal L.M, Polan M.L. Interleukin-1 β increases its own receptor mRNA expression in cultured decidualized human endometrial stromal cells. 40th Annual Meeting of the Society for Gynecologic Investigation (SGI). March – April 1993; Toronto, Canada. Oral Presentation. • Piquette G.N, Simón C , Cabtree M.E, Polan M.L. Interleukin-1b (IL-1b) increases IL- 1 receptor type I (IL-1R tI) messenger ribonucleic acid levels in cultured human granulosa-luteal cells. 40th Annual Meeting of the Society for Gynecologic Investigation (SGI). March – April 1993; Toronto, Canada. Poster Presentation. • Simón C , Francés A, Piquette G.N, Heindrickson M, Polan M.L. Immunohistochemical localization of the Interleukin-1 system in human implantation trophoblast and decidua. Immunobiology of Reproduction, Serono Symposia. August 1993; Boston, USA. Oral Presentation. • El- Danasouri I, Simón C , Francés A, Piquette G.N, Polan M.L. Platelet-activating factor upregulates interleukin-1 receptor type I expression in human endometrial cells in culture. 49th Annual Meeting of the American Fertility Society (AFS). October 1993; Montreal, Canada. Oral Presentation. 1992 • Simón C , Gómez E, Mir A, De los Santos M.J, Pellicer A. Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. 8th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). July 1992; The Hague, The Netherlands. Oral Presentation. • Simón C , Piquette G.N, Cabtree M.E, Westphal L.M, Heinrichs W. L, Polan M.L. Interleukin-1 (IL-1) type I receptor expression in human endometrium during the menstrual cycle. 48th Annual Meeting of the American Fertility Society (AFS). November 1992; New Orleans, USA. Poster Presentation.
134 1991 • Sampaio M, Calatayud C, Miró F, Tarín JJ, Ruiz A, Simón C , Pellicer A. In Vitro responses of mouse granulosa and luteal cells to Thyroid Stimulating Hormone (TSH). 7th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). June 1991; Paris, France. Poster Presentation. • Bonilla-Musoles F, Simón C , Pellicer A, Remohí J. Vaginal endosonographic markers of embryonic malformations. 7th World Congress of IVF and Assisted Procreation. June – July 1991; Paris, France. Poster Presentation. 1990 • Miró F, Simón C , Millet A, Pellicer A. Steroidogenesis in vitro of human granulosa luteal-cells pre-treated in vivo with gonadotropin-releasing hormone analogs. II International Symposium on GnRH Analogues in Cancer and Human Reproduction. November 1990; Geneva, Switzerland. Oral Presentation. 1988 • Simón C , Miró F, Ruiz A, Moreno J.L, Tortajada M, Pellicer A. An analysis of pituitary desensitization with GnRH analogs and in vitro fertilization results starting at different days during the luteal phase. IV Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE). July 1988; Barcelona, Spain. Oral Presentation.
Nationals 2015 • Vera-Rodríguez M, Chavez SL, Rubio C, Reijo-Pera R, Simón C. Alteraciones de los embriones aneuploides en su morfocinética y perfil transcriptómico. VIII Congreso ASEBIR. November 2015; San Sebastián, Spain. Oral Presentation. 2010 • Mercader A, Buendía P, Delgado A, Escrich L, Martín J, Cervero A, Pellicer A, Simón C . El cocultivo embionario con células del endometrio incrementa los resultados clínicos en pacientes del programa de DGP. XXVIII Congreso Nacional Sociedad Española de Fertilidad. May 2010; Valencia, Spain. Oral Presentation • Mir P, Cervero A, Mutlu A, Simón C , Pellicer A, Martín J. Prevención de poliquistosis renal autosómica dominante mediante diagnóstico genético preimplantacional. XXVIII Congreso Nacional Sociedad Española de Fertilidad. May 2010; Valencia, Spain. Oral Presentation 2009 • Medrano JV, Marqués-Marí AI, Poo ME, Aguilar CE, Valbuena D, Ruiz V, Gómez E, Riboldi M, Sánchez E, Galan A, Ruiz-Vela A, Simón C . Enrichment of the vasa positive population produced by spontaneous in Vitro germ line differentiation from HESC by co-localization with CD117 and CD15 membrane cell markers. 5th Bienal congress of the Spanish Society of Gene Cell Therapy. September – October 2009; Granada, Spain. Oral Presentation • Mercader A, Buendía P, Delgado A, Gadea B, Escrich L, Rubio C, Simón C . El cocultivo con células del endometrio favorece el desarrollo embrionario den ciclos de diagnóstico genético preimplantacional por edad materna avanzada. 5º Congreso ASEBIR. November 2009; Valencia, Spain. Poster Presentation 2007 • Cervelló I, Martínez-Romero A, Gil Casanova D, Martínez-Conejero JA, Galán A, Pellicer A, O’Connor JE, Simón C . Side Population in human endometrium: putative adult stem cells. X Congreso de la Sociedad Ibérica de Citometría. June 2007; Barcelona, Spain. Oral Presentation • Galán A, Martínez-Romero A, Herrera G, Sánchez E, Sánchez-Luengo S, Simón C , O’Connor JE. Cuantificación del estado de indiferenciación de las células madre embrionarias humanas mediante inmunofenotipo de superficie. X Congreso de la Sociedad Ibérica de Citometría. June 2007; Barcelona, Spain. Oral Presentation • Medrano JV, Galán A, García A, Valbuena D, Poo ME, Sánchez E, Sánchez-Luengo
135 S, Gómez E, Ruíz V, Simón C . Análisis comparativo de los niveles de expresión de marcadores de indiferenciación en diferentes líneas de células madre embrionarias humanas. IV Congreso de la Sociedad Española de Terapia Génica y Celular. September 2007; Madrid, Spain. Poster Presentation 2006 • Labarta E, Bosch E, De los Santos MJ, Simón C , Remohí J, Pellicer A. Luteinización prematura en ciclos con antagonistas de la GnRH: resultados en función del día de la transferencia embrionaria. XXVI Congreso Nacional de la SEF. May – June 2006; Zaragoza, Spain. Oral Presentation 2005 • Pellicer A, Domínguez P, Horcajadas J, Simón C . Molecular basis of implantation. XXXIII Congreso of the Spanish Society of Physiological Sciences. February 2005; Seville, Spain. Oral Presentation • Berna A, Galán A, Valbuena D, Sánchez S, Melguizo D, Simón C . Células madre. Posibilidades terapêuticas. Simposio Internacional sobre Nuevos Avances en Medicina Reproductiva. October 2005; Valencia, Spain. Oral Presentation • Galán A, Valbuena D, Escobedo C, Rodríguez C, Simón C . Banco de Líneas celulares de Valencia CIPF. III Curso de Terapia Celular. November 2005; Seville, Spain. Oral Presentation 2004 • Garrido N, Meseguer M, Simón C , Remohí J, Pellicer A. Lavado de semen en varones de parejas serodiscordantes para VIH y VHC. Opciones y resultados. XII Reunión del Grupo Uro-Andrológico de la Asociación Española de Urología. March 2004; Valencia, Spain. Oral Presentation • Fernández M, Castillón G, Remohí J, Pellicer A, Simón C . ¿Debemos tender a la transparencia de un blastocisto único electivo?. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Oral Presentation • Meseguer M, Garrido N, Martínez-Conejero JA, Simón C , Pellicer A, Remohí J. Marcadores moleculares de fertilidad espermática y su relación con el análisis básico del semen. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Oral Presentation • Epifanio R, Bosch E, Aizpurua J, Simón C , Remohí J, Pellicer A, Crespo J. Estimulación ovárica en bajas respondedoras: una nueva estrategia. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Oral Presentation • Fernández M, Castillón G, Remohí J, Pellicer A, Simón C . Resultados comparativos entre la LH recombinante y HMG urinaria en la hiperestimulación ovárica controlada (HOC). XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Poster Presentation • Martínez F, Valbuena D, Ubeda A, Domínguez F, Sánchez E, Labastida R, Barri PN, Simón C , Pellicer A. Estudio molecular e histeroscópico y su relación con los fallos repetidos de implantación en FIV. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Poster Presentation • Muñoz EA, Garrido N, Tejera A, Aizpurua J, Simón C , Pellicer A, Remohí J. El hidrosalpinx no afecta la calidad ovocitaria. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Poster Presentation • Vidal C, Bosch E, Bellver J, Castillón G, Crespo J, Simón C , Remohí J, Pellicer A. Mujeres con síndrome ovario poliquístico tienen mejor pronóstico en reproducción asistida que mujeres normovuladoras. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Poster Presentation • Diaz I, Guillén A, Pacheco A, Simón C , Remohí J, Requena A, García Velasco JA. Perfil hormonal en la maduración final ovocitaria con análogos de la GNRH comparado con HCG en ciclos de inseminación artificial. XXV Congreso Nacional de
136 la SEF. May 2004; A Coruña, Spain. Poster Presentation • Muñoz EA, Garrido N, Tejera A, Soares SR, Simón C , Pellicer A, Remohí J. La relativa importancia de la transferencia embrionaria difícil. Un estudio en ovocitos compartidos. XXV Congreso Nacional de la SEF. May 2004; A Coruña, Spain. Poster Presentation 2003 • Martínez-Conejero JA, Garrido N, Remohí J, Pellicer A, Simón C , Meseguer M. Presencia de la mucina MUC1 en el glicocálix del espermatozoide humano. II Congreso de la Asociación para el Estudio de la Biología de la Reproducción (ASEBIR). December 2003; Granada, Spain. Oral Presentation 2002 • Giles J, Requena A, Mínguez Y, Herrer R, Villasante A, Simón C . Utilidad del ICSI en casos de fracaso de IAD. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Aragonés M, Cabañes I, Herrer R, Mínguez I, Garcia-Velasco JA, Simón C . La morfología de los pronúcleos no tiene valor predictivo para el desarrollo del embrión. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Scheffer R, Scheffer B, Garcia-Velasco JA, Remohí J, Pellicer A, Simón C . Relación entre la división embrionaria precoz y la calidad de embriones humanos: estudio preliminar. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Rossal LP, Bosch E, Escudero E, Gaytán J, Remohí J, Pellicer A, Simón C . Validez de los criterios de evaluación embrionaria en el día 3. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Romero J. JI, Rubio C, Rodrigo L, Vidal F, Mínguez Y, Pérez-Cano I, Aragonés M, Martínez MC, Simón C , Remohí J, Pellicer A. Diagnóstico genético preimplantatorio (DGP) en parejas portadoras de translocaciones recíprocas y robertsonianas. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Troncoso C, Bosch E, Escudero E, Bellver J, Valencia I, Simón C , Remohí J, Pellicer A. Estimulación con Citrato de Clomifeno más Gonadotropina Menopáusica Humana en pacientes con baja respuesta a altas dosis de gonadotropinas. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Martinez Salazar J, Scheffer B, Corona J, García Velasco JA, Simón C . ¿Predicen los criterios ecográficos precoces la evolución de las gestaciones obtenidas con fecundación in vitro (FIV)?. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Mifsud A, Mínguez Y, García-Velasco JA, Young EL, Pellicer A, Simón C , Remohí J. La longitud de la región de CAG en el receptor de andrógenos y su asociación con el síndrome de ovarios poliquísticos y la infertilidad masculina. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Scheffer B, García-Velasco JA, Scheffer J, Remohí J, Pellicer A, Simón C . La fertilidad previa de la donante no es un factor pronóstico en la donación de ovocitos. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Corona I, Requena A, Viñuela C, Remohí J, Pellicer A, Simón C . Relación de los días de estimulación ovárica con la calidad de los ovocitos en un programa de donación de ovocitos. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Scheffer B, García-Velasco JA, Scheffer R, Remohí J, Pellicer A, Simón C. ¿Afecta la duración del coasting los resultados del programa de donación de ovocitos?. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de
137 Mallorca, Spain. Oral Presentation • Escudero E, Mercader A, Rossal L.P, Troncoso C, Gaytan J, Remohí J, Pellicer A, Simón C . Resultados perinatológicos del programa de cocultivo embrionario con celulas endometriales epiteliales. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Villasante A, Landazabal A, Requena A, Martinez-Salazar J, García-Velasco JA, Simón C . Factores pronósticos de aborto en gestaciones conseguidas tras fecundación in vitro. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Molina N, Crespo J, Bosch E, Escudero E, Simón C , Remohí J, Pellicer A. Resultados de las técnicas de reproducción asistida en pacientes tratados de cancer. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Oral Presentation • Escobedo MC, Escribá MJ, Remohí J, Pellicer A, Simón C , Verdugo JM. Estudio ultraestructural de blastocistos humanos. Congreso Nacional de la Sociedad Española de Fertilidad. May 2002; Palma de Mallorca, Spain. Poster Presentation 2001 • Gil Salom M, Rubio C, Rodrigo L, Mínguez Y, Remohí J, Simón C y Pellicer A. Valor del FISH de espermatozoides en parejas con fallos repetidos de implantación embrionaria tras ICSI. X Congreso Nacional de Andrología. March 2001; Alicante, Spain. Oral Presentation • Zuzuarregui JL, Marí M, Prados N, Simón C , Remohí J, Pellicer A. Prevalencia de la seropositividad VIH en la población estéril en los años 1991-2000. VI Congreso nacional sobre el SIDA. April 2001; Valencia, Spain. Oral Presentation • Cabañes I, Minguez Y, Aragonés M, Herrer R, García-Velasco J.A, Simón C . ¿Predice la selección de embriones el éxito de una transferencia?. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Cabañes I, Isaza V, Grande J, Mínguez Y, Aragonés M, Herrer R, García-Velasco J.A, Simón C . Valor predictivo de la bhCG precoz en la evolución del embarazo en ART. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Landazabal A, Herrer R, Isaza V, Martínez-Salazar J.F, Requena A, García-Velasco J.A, Remohí J, Pellicer A, Simón C . Creación del perfil de la paciente con optima implantación. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Isaza V, Requena A, García-Velasco J.A, Martín Salazar J, Landazabal A, Remohí J, Simón C . ¿Compromete el coasting los resultados de donación de ovocitos?. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Isaza V, Scheffer B, García-Velasco J.A, Landazabal A, Simón C , Pellicer A. Resultados de coasting en pacientes de muy alto riesgo de SHO. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Isaza V, Párraga M, Anarte C, García-Velasco J.A, Remohí J, Pellicer A, Simón C . La edad de las pacientes afecta a la tasa de embarazo de inseminaciones artificiales. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Martínez-Salazar J, Isaza V, Párraga M, Anarte C, Landazabal A, Requena A, Simón C . Influencia del intervalo entre la administración de HCG y la realización de inseminaciones artificiales en la tasa de embarazo. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Poster Presentation • Pinilla L, Bosch E, Caligara C, Vargas G, Bellver J, Simón C , Pellicer A, Remohí.
138 Incidencia de la cancelación por sangrado en la preparación estrogénica del endometrio para donación de ovocitos. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Caligara C, Camargo F, Pinilla L.F, Escudero E, Navarro J, Bolúmar F, Simón C , Pellicer A, Remohí J. Factores de riesgo para aborto en un programa de donación ovocitaria. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Vargas M.G, Camargo F, Caligara C, Escudero E, Pinilla L, Bosch E, Rossal L.P, Simón C , Remohí J, Pellicer A. Análogos GnRH de acción prolongada; Nuevo factor que afecta la tasa de aborto. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Meseguer M, Garrido N, Zuzuarregui J.L, Romero J.L, Simón C , Remohí J, Pellicer A. Análisis multivariante de factores que influyen en las tasas de gestación e implantación en FIV/ICSI. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Camargo F, Gaytan J, Vargas G, Ferro J, Bosch E, Simón C , Remohí J, Pellicer A. Las medidas ecográficas de la cavidad endometrial al momento de la transferencia embrionaria guardan una directa relación con la tasa de implantación y gestación. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Meseguer M, Garrido N, Zuzuarregui J.L, Romero J.L, Simón C , Remohí J, Pellicer A. ¿Es segura la utilización de semen de donante? Estudios de enfermedades infecciosas y desórdenes genéticos en una población de donantes de semen: 10 años de experiencia. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Escudero E, Rossal L.P, Gaytán P, Simón C , Remohí J, Pellicer A. Sinequias endouterinas: reconstrucción de la cavidad uterina medante histeroscopia quirúrgica y futuro reproductivo. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • Rossal L.P, Escudero E, Bosch E, Simón C , Remohí J, Pellicer A, Ferro J. Evaluación de la necesidad de legrado endometrial aspirativo complementario a la polipectomia histeroscópica. XXVI Congreso Español de Ginecología y Obstetricia. June 2001; Valencia, Spain. Oral Presentation • De los Santos MJ, Mercader A, Albert C, Galán A, Zulategui J, Rodrigo L, Remohí J, Pellicer A, Simón C , Rubio C. Influencia del diagnóstico genético preimplantacional (DGP) en la tasa de implantación de los blastocistos humanos. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Oral Presentation • Gámiz P, Rubio C, Prados N, Romero JLL, Cobo A, Ruiz A, Simón C , Remohí J, Pellicer A, De los Santos MJ. Correlación entre la morfología pronuclear y la presencia de anomalías cromosómicas embrionarias: estudio preliminar. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Oral Presentation • Garrido N, Meseguer M, Gil-Salom M, Simón C , Pellicer A, Remohí J. Caracterización de las poblaciones celulares del eyaculado y biopsia de testículo mediante el análisis del DNA por citometría de flujo. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Oral Presentation • Herrer R, Aragonés M, Scheffer R, Cabañes I, Isaza V, Mínguez Y, Simón C . Relación entre los embarazos múltiples, la calidad embrionaria y la edad de las
139 pacientes. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Oral Presentation • Scheffer R, Cabañes I, Minguez Y, Aragonés M, Herrer R, García-Velasco J.A, Simón C . ¿Predice la selección de embriones el éxito de una transferencia? 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Oral Presentation • Aragonés M, Scheffer R, Mercader A, Isaza V, Mínguez Y, García-Velasco JA, Simón C . La transferencia de blastocistos aumenta la tasa de embarazo en receptoras de ovocitos. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Poster Presentation • Cabañes I, Scheffer R, Isaza V, Grande J, Mínguez Y, Aragonés M, Herrer R, García-Velasco JA, Simón C . Valor predictivo de la PHCG precoz en la evolución del embarazo en ART. 1er Congreso ASEBIR. Asociación para el estudio de la biología de la reproducción. October 2001; Murcia, Spain. Poster Presentation 2000 • Vargas MG, Vidal C, Camargo F, Ibérico G, Cuneo S, Simón C , Remohí J, Pellicer A. Técnicas de reproducción asistida después de los 40 años. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Cuneo S, Vargas G, Caligara C, Camargo F, Pellicer A, Simón C , Remohí J. Diagnóstico y tratamiento adecuados de la infertilidad por agenesia congenita de los conductos deferentes para evitarla en la descendencia. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Crespo J, Navarro J, Simón C , Pellicer A, Remohí J. Adenomiosis e infertilidad: implicaciones clínicas. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Crespo J, Remohí J, Simón C , Pellicer A. Patologías asociadas a adenomiosis en la paciente infertil. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Navarro J, Vargas G, Ferro J, Pellicer A, Simón C , Remohí J. Pronóstico obstétrico tras las corrección de un útero septo en pacientes con infertilidad. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Navarro J, Ibérico G, Remohí J, Simón C , Pellicer A, Ferro J. Corrección del útero septo: comparación entre tijera microquirúrgica y resectoscopia. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz E, Vidal C, Crespo J, Remohí J, Pellicer A, Simón C . Estimulación ovárica en inseminación artificial (IA) con FSH recombinante. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Zuzuarregui J.L, Prados N, Ibérico G, Navarro J, Simón C , Pellicer A, Remohí J. IAD en mujeres sin pareja. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Zuzuarregui J.L, Prados N, Navarro J, Simón C , Pellicer A, Remohí J. IAD en pacientes con ciclos previos de ICSI. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Zuzuarregui J.L, Prados N, Ibérico G, Navarro J, Simón C , Pellicer A, Remohí J. Evolución de la IAD desde 1994. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Isaza V, Requena A, García-Velasco J, Landazábal A, Martínez Salazar J, Remohí J, Pellicer A, Simón C . FSH-urinaria versus FHS-recombinante en pacientes sometidas a inseminación artificial intrauterina: un estudio prospectivo. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Ibérico G, Navarro J, Camargo F, Vidal C, Cúneo S, Simón C , Pellicer A, Remohí J. Tasa de gestación en bajas respondedoras con diferentes protocolos de
140 estimulación ovárica. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz E, Bellver J, Navarro J, Camargo F, Vidal C, Simón C , Pellicer A, Remohí J. Nafarelina VS Leuprorelina Acetato en estimulación ovárica para FIV. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Vargas M.G, Vidal C, Ibérico G, Cuneo S, Simón C , Remohí J, Pellicer A. Características y resultados de pacientes que ingresan a primer ciclo de fertilización in vitro tras fallo en IAH. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Navarro J, Ibérico G, Bosch E, Bellver J, Ferro J, Simón C , Pellicer A, Remohí J. Reducción embrionaria: complicaciones quirúrgicas y pronóstico neonatal según el número de embriones evolutivos. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Navarro J, Bosch E, Díaz I, Ibérico G, Muñoz E, Simón C , Pellicer A, Remohí J. Pronóstico reproductivo en FIV-TE tras miomectomía laparoscópica. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Vargas M.G, Vidal C, Camargo F, Ibérico G, Cuneo S, Simón C , Remohí J, Pellicer A. La fecundación in vitro a través de la edad reproductiva de la mujer. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz E, Bosch E, Mercader A, Pellicer A, Remohí J, Simón C . Relación entre la estimulación ovárica y el desarrollo embrionario. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • De los Santos MJ, Mercader A, Galán A, Romero JL, Ruiz A, Prados N, Cobo A, Remohí J, Pellicer A, Simón C . Valor predictivo de la presencia en cocultivo de tres o más embriones de 8 células en el resultado de la gestación. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Aragonés M, Mínguez Y, Zulategui J, Herrer R, García-Velasco J.A, Remohí J, Pellicer A, Simón C . Viabilidad embrionaria tras el proceso de congelación/descongelación en ciclos de ICSI o FIV convencional. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Isaza V, Martinez Salazar J, Requena A, García-Velasco J.A, Remohí J, Pellicer A, Simón C . La administración de agonistas de la hormona liberadora de gonadotrofina (A-GnRH) es útil en la transferencia de embriones descongelados en ciclos con terapia hormonal sustitutiva. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Rodríguez M, Ibérico G, Camargo F, Vargas G, Caligara C, Simón C , Remohí J, Pellicer A. Influencia del efecto “vanishig” en la evolución obstétrica de gestaciones múltiples obtenidas tras donación ovocitaria. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Ibérico G, Navarro J, Rodríguez M, Camargo F, Vargas G, Simón C , Remohí J, Pellicer A. Cuando proponer la ovodonación en pacientes bajas respondedoras. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Bellver J, Cuneo S, Ruiz A, Remohí J, Simón C , Pellicer A, Navarro J. Calidad embrionaria en una estimulación con respuesta asincronica. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Ibérico G, Remohí J, Simón C , Pellicer A, Navarro J. Calidad ovocitaria en una estimulación con respuesta asincronica. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Herrer R, Mínguez Y, Aragonés M, Zulategui J, García-Velasco J.A, Remohí J, Pellicer A, Simón C . Correlación de la distribución de los nucleolos con el desarrollo
141 embrionario. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz J, Aragonés M, Mínguez Y, Herrer R, García-Velasco J.A, Remohí J, Pellicer A, Simón C . Microinyección intracitoplasmática (ICSI) en ovocitos metafase I (MI). XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Isaza V, García-Velasco J, Requena A, Martinez-Salazar J, Landazábal A, Remohí J, Pellicer A, Simón C . Protocolo stop versus altas dosis de gonadotrofinas en pacientes de FIV con baja respuesta: estudio prospectivo, randomizado y controlado. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Landazábal A, García-Velasco J, Martinez-Salazar J, Requena A, Isaza V, Grande J, Remohí J, Pellicer A, Simón C . Influencia de diferentes protocolos de hiperestimulación ovárica controlada en el microambiente endocrinológico del folículo: efectos de la fshr (Gonal F) y del antagonista de la GnRH (Cetrorelix). XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Garrido N, O’Connor JE, Remohí J, Simón C , Pellicer A. Expresión, producción y secreción del factor vascular de crecimiento endotelial (VEGF) e interleuquina-6 (IL- 6) en las células de la granulosa en mujeres con endometriosis. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Ibérico G, Navarro J, Serra V, Rodríguez M, Ferro J, Simón C , Pellicer A, Remohí J. Reducción embrionaria: estudio comparativo con gestaciones simples y múltiples no reducidas. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Ibérico G, Navarro J, Bosch E, Rodríguez M, Ferro J, Simón C , Pellicer A, Remohí J. Reducción embrionaria: complicaciones quirúrgicas y pronóstico neonatal según la edad gestacional a la que se practicó la reducción. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Ibérico G, Navarro J, Bosch E, Vidal C, Bellver J, Simón C , Pellicer A, Remohí J. Reducción embrionaria en gestaciones múltiples de alto riesgo: relación entre el número de embriones reducidos y la morbilidad quirúrgica temprana. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Andreu S, Serra V, Vergara F, Simón C , Pellicer A, Remohí J. Pronóstico obstétrico y perinatal tras técnicas de reproducción asistida. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Vargas M, Ibérico G, Navarro J, Camargo F, Simón C , Pellicer A, Remohí J. Malformaciones fetales asociadas a reducción embrionaria. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Bosch E, Navarro J, Vidal C, Simón C , Remohí J, Pellicer A. Estimulación con CC+hMG en pacientes con baja respuesta a altas dosis de gonadotropinas. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Cabañes I, Mínguez Y, Herrer R, Aragonés M, García-Velasco J.A, Remohí J, Pellicer A, Simón C . Resultados de ICSI en pacientes con eyaculación retrograda. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Mínguez Y, Rubio C, Vidal F, García-Velasco J, Martinez-Salazar J, Aragonés M, Requena A, Remohí J, Pellicer A, Simón C . Embarazo tras diagnóstico preimplantatorio en una pareja portadora de una translocación cromosómica equilibrada. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation
142 • Rodrigo L, Rubio C, Vidal F, Blanco J, Remohí J, Pellicer A, Simón C , Gil-Salom M. Hibridación in situ fluorescente (FISH) de espermatozoides obtenidos de biopsia de testículo y de epididimo, en pacientes candidatos para ICSI. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo F, Ibérico G, Cobo A, Remohí J, Simón C , Pellicer A, Navarro J. Pronóstico reproductivo de las pacientes infertiles con adenomiosis tras tres meses de tratamiento con análogos de la GnRh. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz E, Rodriguez M, Ferro J, Navarro J, Simón C , Pellicer A, Remohí J. Uso de albúmina en paciente de riesgo para síndrome de hiperestimulación ovárica (SHO). XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Bosch E, Caligara C, Navarro J, Simón C , Pellicer A, Remohí J. La relación grosor endometrial-tasa de implantación varía con la edad. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Camargo, F, Ibérico G, Cobo A, Remohí J, Simón C , Pellicer A, Navarro J. Pronóstico reproductivo de una respuesta ovárica asincrónica a la estimulación. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Muñoz E, Landeras J, Ballesteros A, Pellicer A, Simón C , Remohí J. Predictores de sangrado en ciclo de preparación para donación de ovocitos. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Martínez Salazar J, Isaza V, Anarte C, Requena A, García-Velasco J, Landazabal A, Simón C . Comparación de los resultados del programa de donación de ovocitos, según el número de óvulos maduros obtenidos en cada donante. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Meseguer M, Martín J, Galán A, Remohí J, Pellicer A, Simón C . MUC1 actúa como barrera selectiva durante la implantación embrionaria y es regulada por el embrión humano. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Santos M.J, Mercader A, Galán A, Romero J.L, Ruiz A, Prados N, Cobo A, Remohí J, Pellicer A, Simón C . Valor de la presencia en cocultivo de tres o más embriones de 8 células en el resultado de la gestación. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Oral Presentation • Bosch E, Caligara C, Navarro J, Simón C , Pellicer A, Remohí J. Valor predictivo del grosor endometrial en donación de ovocitos. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Poster Presentation • Caligara C, Vargas G, Camargo F, Vidal C, Navarro J, Simón C , Pellicer A, Remohí J. ¿Afecta la hiperestimulación ovárica repetida la recuperación ovocitaria en donantes? XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Poster Presentation • Anarte C, Requena A, García-Velasco J, Martínez-Salazar J, Isaza V, Landazábal A, Remohí J, Pellicer A, Simón C . Influencia del tabaco en la madurez ovocitaria en un programa de donación de óvulos. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Poster Presentation • Anarte C, Grande J, Requena A, García-Velasco J, Martínez-Salazar J, Landazábal A, Remohí J, Pellicer A, Simón C . Estudio del perfil hepático y de coagulación en pacientes incluídas en un programa de donación de óvulos. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Poster Presentation • Vidal C, Crespo J, Lara C, Ferro J, Serra V, Simón C , Remohí J, Pellicer A. Mola parcial en el primer trimestre en embarazos post-reproducción asistida. XXIII Congreso Nacional de la Sociedad Española de Fertilidad. May 2000; Seville, Spain. Poster Presentation
143 • Ferro J, Vargas G, Camargo F, Cuneo S, Vidal C, Ibérico G, Caligara C, Remohí J, Pellicer A, Simón C . Pseudo linfoma de endometrio. Imagen histeroscópica. Caso clínico. Congreso Nacional de Endoscopia Ginecológica. May – June 2000; Madrid, Spain. Oral Presentation • Camargo F, Vargas G, Cuneo S, Caligara C, Remohí J, Pellicer A, Simón C , Ferro J. Corrección de un útero septado. Uso de tijera microquirúrgica versus resectoscopia. Congreso Nacional de Endoscopia Ginecológica. May – June 2000; Madrid, Spain. Oral Presentation 1999 • Alvarez J.C, Muñoz E, Vergara F, Díaz I, Ibérico G, Simón C , Pellicer A, Remohí J. Embarazo heterotópico asintomático con gestación múltiple. Revisión de la literatura. V Reunión de la sección de reproducción de la Sociedad de Obstetricia y Ginecologia de la Comunidad Valenciana. January 1999; Requena, Valencia, Spain. Oral Presentation • Alvarez J.C, Vergara F, Díaz I, Muñoz E, Landazabal A, Simón C , Pellicer A, Remohí J.Transferencia intratubárica de embriones. Resultados preliminares. V Reunión de la sección de reproducción de la Sociedad de Obstetricia y Ginecologia de la Comunidad Valenciana. January 1999; Requena, Valencia, Spain. Oral Presentation • Díaz I, Vergara F, Alvarez J.C, Simón C , Pellicer A, Remohí J. Miomectomía laparoscópica y Reproducción Asistida. V Reunión de la sección de reproducción de la Sociedad de Obstetricia y Ginecologia de la Comunidad Valenciana. January 1999; Requena, Valencia, Spain. Oral Presentation • Herrer R, Domínguez F, Caballero-Campo P, Remohí J, Pellicer A, Simón C . El sistema de vídeo “time lapse”, una nueva aproximación para el estudio del desarrollo embrionario. VI Certamen Nacional de Video en Obstetricia y Ginecología. April 1999; Lugo, Spain. Oral Presentation • Alvarez JC, Caballero P, Rodríguez M, Simón C , Pellicer A, Remohí J. Transferencia intratubárica de embriones, una alternativa frente a la estenosis cervical. VI Certamen Nacional de Video en Obstetricia y Ginecología. April 1999; Lugo, Spain. Oral Presentation • Galán A, O´Conor J.E, Meseguer M, Caballero P, Garrido N, Simón C . Análisis de la proliferación y apoptosis en cultivos de células epiteliales de Endometrio. VI Congreso de la Sociedad Ibérica de Citometría. June 1999; Salamanca, Spain. Oral Presentation • Caballero-Campo P, Meseguer M, Garrido N, Galán A, Jasper M, Coloma J, O ´Conor J.E, Simón C . Regulación embrionaria sobre células del epitelio endometrial humano por las quimiocinas interleuquina-8 (IL-8) y proteina quimiotactica de monocitos (MCP-1): Aplicación de la citometria de flujo en la investigación en reproducción asistida. VI Congreso de la Sociedad Ibérica de Citometría. June 1999; Salamanca, Spain. Oral Presentation • Garrido N, O’Connor J.E, Meseguer M, Martín J.C, Galán A, Caballero-Campo P, Simón C , Pellicer A. Análisis de las subpoblaciones leucocitarias del folículo ovárico en pacientes con endometriosis: aplicaciones de la citometria de flujo en la investigación en ginecologia. VI Congreso de la Sociedad Ibérica de Citometría. June 1999; Salamanca, Spain. Oral Presentation • Meseguer M, O´Conor J.E, Caballero-Campo P, Garrido N, Martín J.C, Galán A, Simón C . Regulacion de la mucina MUC1: Aplicaciones de la citometria de flujo a la investigación en reproducción asistida. VI Congreso de la Sociedad Ibérica de Citometría. June 1999; Salamanca, Spain. Oral Presentation • Alvarez J.C, Vergara F, Rodríguez M, Pellicer A, Simón C , Remohí J. Transferencia intratubárica de embriones en donación de ovocitos. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation
• Andreu S, Vergara F, Muñoz E, Simón C , Pellicer A, Remohí J. Miomas y tasa de aborto en pacientes receptoras de donación de ovocitos. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation
144 • Díaz I, Navarro J, Muñoz E, Simón C , Pellicer A, Remohí J. Impacto de los estadios III-IV de endometriosis en el resultado de receptoras de ovocitos procedentes de la misma donante. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Díaz I, Vergara F, Álvarez J.C, Simón C , Pellicer A, Remohí J. Miomectomía laparoscópica y resultados de fecundación in vitro (F.I.V) en pacientes con fallos en ciclos previos a la cirugía. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Ibérico G, Vergara F, Landazábal A, Simón C , Pellicer A, Remohí J. Tasa de gestación y aborto en pacientes con F.I.V. previo o posterior a salpinguectomía por hidrosálpinx. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Muñoz E, Díaz i, Vidal C, Simón C , Pellicer A, Remohí J. Donación ovocitaria en pacientes con disgenesia gonadal. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Muñoz E, Vidal C, Muñoz M, Simón C , Pellicer A, Remohí J. La importancia de los pólipos endometriales en la reproducción asistida. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Vergara F, Alvarez J.C, Díaz I, Simón C , Pellicer A, Remohí J. Resultados de un programa satélite en reproducción asistida. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Zuzuarregui J, Álvarez J.C, Prados N, Simón C , Pellicer A, Remohí J. Influencia de la Edad en la inseminación artificial de donante. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Mínguez Y, Rubio C, Vidal F, Caballero P, Remohí J, Pellicer A, Simón C . Diagnóstico preimplantatorio: indicaciones y resultados. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Poster Presentation • Requena A, Neuspiller F, Cobo A, Aragonés M, Remohí J, Pellicer A, Simón C . Aplicación de la maduración in vitro de ovocitos en bajas respondedoras a la estimulación ovárica. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Poster Presentation • Requena A, García Velasco J.A, Martínez-Salazar F.J, Caballero P, Simón C , Pellicer A. Efectos de la diabetes sobre la maduración del ovocito. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Poster Presentation • Landazabal A, Muñoz E, Rodríguez M, Simón C , Remohí J, Pellicer A. Malformación uterina por exposición in útero al dietilestilbestriol (DES) a fallo ovárico oculto y gestación por reproducción asistida. XXV Congreso Español de Ginecología y Obstetricia. June 1999; Zaragoza, Spain. Oral Presentation • Rubio C, Vidal F, Mínguez Y, Blanco J, Giménez C, Romero J, Remohí J, Egozcue J, Pellicer A, Simón C . Incidencia de anomalías cromosómicas en embriones y espermatozoides de parejas con aborto de repetición. XX Congreso Nacional de Genética Humana. June 1999; Valencia, Spain. Oral Presentation • Díaz I, Ferro J, Landazabal A, Muñoz E, Simón C , Pellicer A, Remohí J. Efecto de la miomectomia laparoscópica en los resultados de fecundación in vitro. 3er congreso de la Sociedad Latina de Biología y Medicina de la Reproducción (SO.LA.ME.R). October 1999; Barcelona, Spain. Oral Presentation • Landazabal A, Ferro J, Muñoz E, Ibérico G, Simón C , Pellicer A, Remohí J. Tratamiento laparoscópico del embarazo ectópico intersticial después de FIV/ET. 3er congreso de la Sociedad Latina de Biología y Medicina de la Reproducción (SO.LA.ME.R). October 1999; Barcelona, Spain. Oral Presentation 1998 • Muñoz M, Alvarez JC, Ardiles G, Neuspiller F, Pellicer A, Simón C , Remohí J. Incidencia de cancelación de ciclos en donación de ovocitos: influencia de la edad. V Congreso Nacional de la Asociación Española para el Estudio de la Menopausia. April 1998; Valencia, Spain. Oral Presentation • Navarro J, Ardiles G, Neuspiller F, Alvarez J.C, Rodríguez M, Pellicer A, Simón C ,
145 Remohí J. Donación de ovocitos en mujeres perimenopáusicas. V Congreso Nacional de la Asociación Española para el Estudio de la Menopausia. April 1998; Valencia, Spain. Oral Presentation • Neuspiller F, Navarro J, Ardiles G, Muñoz M, Pellicer A, Simón C , Remohí J. Donación de ovocitos en mujeres con menopausia precoz. V Congreso Nacional de la Asociación Española para el Estudio de la Menopausia. April 1998; Valencia, Spain. Oral Presentation • Ardiles G, Neuspiller F, Navarro J, Díaz I, Requena A, Pellicer A, Simón C , Remohí J. Días de estradiol y donación de ovocitos en la perimenopausia. V Congreso Nacional de la Asociación Española para el Estudio de la Menopausia. April 1998; Valencia, Spain. Oral Presentation • Rodríguez M, Muñoz M, Requena A, Navarro J, Vidal C, Simón C , Pellicer A, Remohí J. Transferir 3 ó 4 embriones en FIV ¿Cual es la mejor opción?. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Albert C, Mercader A, Remohí J, Simón C , Pellicer A. Origen del síndrome de hiperestimulación ovárica (SHO). XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Gaitán P, Moreno C, Zulategui J, Ruíz A, Simón C , Remohí J, Pellicer A. Transferencias de embriones criopreservados en ciclos natural y sustituido. Resultados. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Ardiles G, Neuspiller F, Vergara F, Muñoz M, Díaz I, Crespo J, Simón C , Pellicer A, Remohí J. Receptividad endometrial en donación de ovocitos. Factores predictivos. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Vergara F, Andreu S, Diaz I, Alvarez J.C, Requena A, Simón C , Pellicer A, Remohí J. Resultados perinatales en un programa de donación de ovocitos (DO). XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Alvarez J. C, Neuspiller F, Ardiles G, Vergara F, Requena A, Simón C , Pellicer A, Remohí J. Resultados reproductivos del programa de donación de ovocitos en pacientes con fallo ovárico precoz (FOP) y menopausia quirúrgica. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Díaz I, Rodríguez M, Neuspiller F, Ardiles G, Alvarez J.C, Simón C , Pellicer A, Remohí J. Donación ovocitaria en pacientes mayores de 50 años. Resultados. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Mercader A, Herrer R, Remohí J, Pellicer A, Simón C . Co-cultivo de embriones con células del epitelio endometrial humano hasta el estadio de blastocisto. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Albert C, Mercader A, Remohí J, Simón C , Pellicer A. Producción sistemática y ovárica de vascular endothelial growth factor (VEGF), Interleukina (IL)-1B, e IL-6 en mujeres con síndrome de ovarios poliquísticos (PCO). XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Neuspiller F, Ardiles G, Vergara F, Alvarez J.C, Muñoz M, Simón C , Pellicer A, Remohí J. Supresión ovárica con diferentes análogos en el programa de donación de ovocitos. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Díaz I, Ardiles G, Neuspiller F, Sánchez R, Moreno C, Simón C , Pellicer A, Remohí J. Miomectomia laparoscópica y reproducción asistida. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Alvarez J.C, Muñoz M, Neuspiller F, Ardiles G, Díaz I, Simón C , Pellicer A, Remohí J. Malformaciones müllerianas, tratamiento histeroscópico y fertilidad posterior. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid,
146 Spain. Oral Presentation • Mercader A, Herrer R, Ruíz A, Simón C . Estudio del desarrollo en embriones cocultivados con células del epitelio endometrial humano. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Mínguez Y, Vidal F, Rubio C, Giménez C, Remohí J, Egozcue J, Pellicer A, Simón C. Diagnóstico genético preimplantatorio indicaciones y resultados. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Moreno C, Gaitán P, Alvarez J, Zulategui J, Pellicer A, Remohí J, Simón C . Resultados reproductivos en receptoreas de nuestro programa de donación de ovocitos de acuerdo al origen de los ovocitos recibidos. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Vergara F, Andreu S, Díaz I, Rodríguez M, Crespo J, Simón C , Pellicer A, Remohí J. Patología obstétrica en gestaciones logradas por donación de ovocitos. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Muñoz M, Alvarez J.C, Ardiles G, Neuspiller F, Requena A, Simón C , Pellicer A, Remohí J. Embarazo ectópico y reproducción asistida. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation • Requena A, Neuspiller F, Cobo A, Aragonés M, Rubio C, Simón C , Pellicer A, Remohí J. Estudio endocrinológico del ciclo ovárico tras aspiración folicular en un programa de maduración ovocitaria in-vitro. XXII Congreso Nacional de la Sociedad Española de Fertilidad. May 1998; Madrid, Spain. Oral Presentation 1997 • Zuzuarregui JL, Gaitán P, García-Velasco JA, Simón C , Pellicer A. Prevalencia de la seropositividad VIH en la población esteril. IV Congreso nacional sobre el SIDA. April 1997; Valencia, Spain. Oral Presentation • Mercader A, Simón C , Albert C, Herrer R, Caballero P, Remohí J, Pellicer A. Cocultivo de embriones sobre células epiteliales del endometrio humano en pacientes con repetidos fallos de implantacion. Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Oral Presentation • Rubio c, Simón C , Vidal F, Giménez C, Romero JLI, Mercader A, Remohí J, Pellicer A. Desarrollo embrionario e incidencia de alteraciones cromosómicas en un programa de diagnóstico preimplantatorio. Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Oral Presentation • Rubio C, Vidal R, Giménez C, Mínguez Y, Bernal A, Remohí J, Pellicer A, Simón C . Diagnóstico preimplantatorio mediante hibridación "in situ" con fluirescencia (FISH) en una paciente portadora de una translocación Robertsoniana entre los cromosomas 13 y 14 Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Oral Presentation • Grimalt L, Landores J, Bernal A, Simón C , Remohí J, Pellicer A. Microinyección intracitoplasmática y amniocentesis precoz. Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Oral Presentation • Martínez-Salazar FJ, Landeras J, Levy M, Yalil S, Neuspiller F, García Velasco JA, Simón C , Pellicer A, Remohí J. Capacidad Reproductiva femenina tras ligadura tubárica. Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Poster Presentation • Landeras J, Martínez-Salazar FJ, Levy M, Yalil S, Neuspiller F, García Velasco JA, Simón C , Pellicer A, Remohí J. Capacidad Reproductiva masculina tras vasectomia. Sociedad Española de Ginecología y Obstetricia. June 1997; Marbella, Spain. Poster Presentation • Vidal F, Giménez C, Rubio C, Calafell JM, Grossman M, Simón C , Cívico S, Marina F, Egozcue J, Santaló J. Diagnóstico preimplantacional en enfermedades ligadas al sexo. XXIV Symposium Internacional de Fertilidad 97. Institut Universitari Dexeus. November 1997; Barcelona, Spain. Oral Presentation • Rubio C, Vidal F, Giménez C, Egozcue J, Pellicer A, Simón C . Diagnóstico preimplantatorio de alteraciones cromosómicas embrionarias en pacientes con
147 aborto de repetición XXIV Symposium Internacional de Fertilidad 97. Institut Universitari Dexeus. November 1997; Barcelona, Spain. Oral Presentation 1996 • Raga F, Bauset C, Simón C , Bonilla-Musoles F. Endometriosis en las pacientes afectas de anomalías müllerianas. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Valbuena D, Guanes PP, Remohí J, Pellicer A, Simón C . Efectos de los analogos de la GnRH sobre la función del cuerpo lúteo humano. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Crespo J, Mínguez Y, Amorocho B, Pérez Cano I, Zuzuarregui JL, Romero J, Simón C, Pellicer A, Remohí J. ICSI con semen congelado versus semen fresco en un programa de donación de ovocitos. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Gallardo E, Guanes PP, Levy M, Yalil S, Simón C , Pellicer A, Remohí J. Influencia de la edad masculina sobre la capacidad de fertilización espermática: La donación de ovocitos como modelo. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • García-Velasco JA, Guanes PP, Gallardo E, Yalil S, Gartner B, Simón C , Pellicer A, Remohí J. Doppler de arterias uterinas y edad materna en pacientes sometidas a donación de ovocitos. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Rodríguez M, Ruiz A, Remohí J, Pellicer A, Simón C . Tras un primer fallo de implantación, ¿Cuántos embriones deberíamos transferir en el segundo intento?. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Levy M, Gallardo E, Guanes PP, García VJ, Valbuena D, Remohí J, Simón C , Pellicer A. Incidencia del embarazo ectópico en reproducción asistida. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Romero J, Mercader A, De los Santos MJ, Ruíz A, Mínguez Y, Rubio C, Gimeno MJ, Remohí J, Simón C . Resultados de un programa de cocultivo embrionario con epitelio endometrial humano. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Valbuena D, Gimeno MJ, Mercader A, Remohí J, Pellicer A, Devoto L, Simón C . Localización inmunohistoquímica del sistema de la IL-1 en el cuerpo lúteo humano. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Levy M, Gallardo E, Yalil S, Valbuena D, García JA, Cobo AC, Simón C , Pellicer A, Remohí J. Administración prolongada de estrógenos para la preparación endometrial en donación de ovocitos. Resultados. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Levy M, Gallardo E, Guanes PP, De los Santos MJ, Yalil S, Simón C , Pellicer A, Remohí J. Donación de ovocitos en aborto recurrente. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • García-Velasco JA, Gallardo E, Guanes PP, Levy M, Parrilla JJ, Brassesco M, Simón C , Remohí J. Embarazo tras donación de ovocitos en disgenesias gonadales. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Yalil S, Gallardo E, Guanes PP, Gartner B, Valbuena D, Simón C , Pellicer A, Remohí J. Niveles séricos de estradiol en receptoras de ovocitos. Su influencia sobre la capacidad de implantación en donación de ovocitos. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Yalil S, Guanes PP, Gallardo E, García-Velasco JA, Cobo A, Simón C , Pellicer A, Remohí J. Donación de ovocitos: Resultados de 5 años de experiencia. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation
148 • Grimalt L, Jiménez MA, Simón C , Remohí J, Pellicer A, Ruiz A. Primer año de procedimientos FIV en el IVI Castellón. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Valbuena D, Gallardo E, Gartner B, Levy M, Yalil S, Cobo A, Simón C , Pellicer A, Remohí J. Donación de ovocitos de acuerdo a la edad de las receptoras. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • Rubio C, Francés A, Vidal F, Jiménez C, Remohí J, Pellicer A, Egozcue J, Simón C . Biópsia embrionaria y diagnóstico preimplantatorio para la determinación del sexo en embriones humanos. Resultados preliminares. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation • De los Santos MJ, Romero J, Mercader A, Remohí J, Simón C . Los cocultivos en los fallos de implantación. XXI Congreso Nacional de la Sociedad Española de Fertilidad. June 1996; Tenerife, Spain. Oral Presentation 1994 • Romero J, Oliveira N, Simón C , Grimalt L, Remohí J, Pellicer A, Tarín J. Correlación entre la morfología del acrosoma y la fecundación in vitro. XX Congreso Nacional de la Sociedad Española de Fertilidad. May 1994; Valencia, Spain. Oral Presentation
• De los Santos MJ, Rubio C, Simón C , Remohí J, Pellicer A, Tarín J. Inducción de la reacción acrosómica previa a la microinyección espermática en el espacio perivitelino (SUZI XX Congreso Nacional de la Sociedad Española de Fertilidad. May 1994; Valencia, Spain. Oral Presentation • Ballesteros A, Molero MD, Rubio MC, Oliveira N, Mercader A, Simón C , Pellicer A, Remohí. Hiperestimulación ovárica severa en ciclos estimulados para FIV. I Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana. October 1994; Valencia, Spain. Oral Presentation • Cano F, Ruiz A, Gallardo E, Grimalt L, Amorocho B, Simón C , Pellicer A, Remohí J. Utilidad del factor liberador de la hormona de crecimiento (GRF) en el FIV. I Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana. October 1994; Valencia, Spain. Oral Presentation • Cano F, Romero J, Gómez PP, Valbuena D, Simón C , Pellicer A, Remohí J. Ventajas de la implementación del desarrollo folicular multiple (DFM) con gonadotrofinas en un programa de IAC. I Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana. October 1994; Valencia, Spain. Oral Presentation • Zuzuarregui JL, Romero JL, Cano F, Mínguez Y, Chamorro MN, Simón C , Pellicer A, Remohí J. Estimulación con Gonadotrofinas en IAD. I Reunión de la Sección de Reproducción de la Sociedad de Obstetricia y Ginecología de la Comunidad Valenciana. October 1994; Valencia, Spain. Oral Presentation 1991 • Navarro JE, Simón C , Matallín P, Valero V, Colom E, Bonilla-Musoles F. Test de Estimulación sónica. Valor predictivo del estado fetal. XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Simón C , Matallín P, Martorell M, Torres JV. Carcinoma verrucoso vulvar ¿Neoplasia o Condiloma? XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Simón C , Pellicer A, Matallín P, Bonilla-Musoles F. Reducción embrionaria en un caso de septuples. XXI Congreso Español de Ginecología y Obstetricia. XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Matallín P, Simón C , Martorell M, Torres JV. Citometría de flujo en melanomas malignos vulvares. XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Simón C , Pellicer A, Remohí J, Bonilla-Musoles F, Navarro E. Reducción
149 embrionaria. XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Raga F, Simón C , Dolz M, Pérez-Gil M, Tortajada M, Bonilla-Musoles. Incompetencia cervical; comparación diagnóstica entre ecografía abdominal perinatal y vaginal. XXI Congreso Español de Ginecología y Obstetricia. May 1991; Alicante, Spain. Oral Presentation • Simón C , Pardo F, Martínez L, Tortajada M, Pellicer A. Incidencia e impacto reproductivo de las malformaciones uterinas en la población fértil. Reunion Nacional de la Sociedad Española de Fertilidad. November 1991; Granada, Spain. Oral Presentation • Simón C , Tortajada M, Pellicer A. Influencia del número de gestaciones previas sobre la incidencia de abortos en pacientes normales. Reunion Nacional de la Sociedad Española de Fertilidad. November 1991; Granada, Spain. Oral Presentation 1990 • Simón C , Tarín JJ, Matallín P, Sampaio M, Castellvi RM, Pellicer A. Relación entre anomalías cromosómicas en ovocitos humanos, causa de esterilidad, protocolo de estimulación y dosis de gonadotrofinas. XIX Congreso Nacional de la Sociedad Española de Fertilidad. October 1990; San Sebastián, Spain. Oral Presentation
• Gómez E, Tarín JJ, Ruiz A, Castellvi RM, Miró F, Simón C , Bonilla-Musoles F. Congelación ultrarápida de embriones humanos. Nuestra experiencia. XIX Congreso Nacional de la Sociedad Española de Fertilidad. October 1990; San Sebastián, Spain. Oral Presentation • Matallín P, Tarín JJ, Simón C , Castellvi RM, Sampaio M, Bonilla F. Efectos del tabaco en los ovocitos humanos: Analisis citogenético. XIX Congreso Nacional de la Sociedad Española de Fertilidad. October 1990; San Sebastián, Spain. Oral Presentation • Gómez E, Tarín J, Simón C , Molero MD, Remohí J. Experiencia programa FIV (1988-1989). Revisión de resultados en 368 casos. XIX Congreso Nacional de la Sociedad Española de Fertilidad. October 1990; San Sebastián, Spain. Oral Presentation • Simón C , Tarín J, Gómez E, Molero MD, Remohí J. Estimulación ovárica en un programa FIV. XIX Congreso Nacional de la Sociedad Española de Fertilidad. XIX Congreso Nacional de la Sociedad Española de Fertilidad. October 1990; San Sebastián, Spain. Oral Presentation 1989 • Simón C , Sampaio M, Pérez-Gil M, Bonilla-Musoles F. Patología de la vesícula vitelina y su repercusión sobre el embarazo. XX Congreso Español de Ginecología y Obstetricia. May 1989; Palma de Mallorca, Spain. Oral Presentation • Simón C , Sampaio M, López-Viveros C, Bonilla-Musoles F. Diagnóstico precoz del carcinoma de ovario con endosonografía vaginal. XX Congreso Español de Ginecología y Obstetricia. May 1989; Palma de Mallorca, Spain. Oral Presentation 1988 • Alonso MD, Simón C , Marco A, Marcos JM, Seler JM, Gallego J, Lavernia M, Torres JV, Palanca JM, Chulia V. Estudio de las alteraciones lipídicas tras anestesia general con isofluorano en pacientes oncológicas. XIX Congreso Nacional de Anestesiología-Reanimación y Terapia del Dolor. May 1988; Santander, Spain. Oral Presentation 1987 • Blanes J, Simón C , Matallín P, Bonilla-Musoles F. Parámetros ecográficos en el control de la ovulación y del cuerpo lúteo normales y patológicos para un programa FIV-TE. XIX Congreso Nacional de la Asociación Ginecológica Española. October, 1987; Oviedo, Spain. Oral Presentation • Simón C , Pérez-Gil M, Tortajada M. Biopsia corial. XIX Congreso Nacional de la Asociación Ginecológica Española. October, 1987; Oviedo, Spain. Oral Presentation
150 1985 • Simón C . Cirugía fetal intraútero en la hidrocefalia y patología renal congénita. XVIII Reunión de Ginecólogos Españoles. April 1985; Granada, Spain. Oral Presentation
151