+MRIOSP4SP 46%')43+0Á(3;) ginekologia

Endometrial receptivity – can it be diagnosed and controlled? And why does it matter?

Receptywność endometrium – czy potrafimy ją zdiagnozować i kontrolować? Czy ma to znaczenie?

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Division of Reproduction, Poznan University of Medical Sciences, Poland

Abstract Infertility remains a challenge to modern medicine. Despite extensive diagnostic and therapeutic procedures, the achievement of pregnancy remains an elusive goal in some patients. The endometrium is one of the key factors in embryo implantation. Older methods of describing endometrial receptivity, like histology or ultrasound, did not bring noticeable improvement in pregnancy rates. New technologies, including genomics, proteomics, lipidomics, and secretomics promise to improve the detection of the implantation window in the endometrium and result in better counseling of patients with infertility.

Key words: LQIHUWLOLW\ / HQGRPHWULXP / ZLQGRZ RI LPSODQWDWLRQ / UHFHSWLYLW\ / / SURWHRPLFV / VHFUHWRPLFV / OLSLGRPLFV / JHQRPLFV / PHWDERORPLFV /

Streszczenie Niepłodność jest jednym z głównych wyzwań współczesnej medycyny. Pomimo szerokiego wachlarza procedur diagnostycznych i terapeutycznych uzyskanie ciąży u niektórych par pozostaje niespełnione. Kluczowym czynnikiem odgrywającym rolę w implantacji jest endometrium. Starsze metody opisywania receptywnego endometrium, takie jak ocena histologiczna czy ultrasonograficzna, nie przyczyniły się do zauważalnego wzrostu liczby ciąż. Nowe techniki, takie jak oznaczanie za jednym razem wielu genów, białek, produktów lipidowych czy procesów metabolicznych, obiecują poprawę nie tylko w wyznaczaniu okna implantacyjnego w endometrium, ale i w poradnictwie par z niepłodnością.

Słowa kluczowe: QLHSáRGQRĞü / HQGRPHWULXP / RNQR LPSODQWDF\MQH / UHFHSW\ZRĞü / / SURWHRPLND / VHNUHWRPLND / OLSLGRPLND / JHQRPLND / PHWDERORPLND /

Corresponding author: Mateusz Mikołajczyk Division of Reproduction Polna 33, 60-535 Poznań, Poland Tel. 0048616599302 Otrzymano: 22.04.2013 Zaakceptowano do druku: 30.09.2013 e-mail: [email protected]

Nr 2/2014 © Polskie Towarzystwo Ginekologiczne 149 46%')43+0Á(3;) +MRIOSP4SP ginekologia

Mateusz Mikołajczyk, Jana Skrzypczak. Endometrial receptivity – can it be diagnosed and controlled? And why does it matter?

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Nr 2/2014 © Polskie Towarzystwo Ginekologiczne 151 46%')43+0Á(3;) +MRIOSP4SP ginekologia

Mateusz Mikołajczyk, Jana Skrzypczak. Endometrial receptivity – can it be diagnosed and controlled? And why does it matter?

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Mateusz Mikołajczyk – autor koncepcji i założeń pracy, przygotowanie manuskryptu i piśmiennictwa – autor zgłaszający i odpowiedzialny za PHWDEROLFSURWHLQDQGOLSLGFRQWHQWPDNHVLWDQLGHDOFDQGLGDWH manuskrypt. WRVWXG\HQGRPHWULDOUHFHSWLYLW\ 2. Jana Skrzypczak – ostateczna weryfikacja i akceptacja manuskryptu, autor kilku prac omawianych w zgłoszonym artykule. Comorbidities $SDUW IURP PROHFXODU DQG JHQHWLF FKDQJHV LQ WKH Źródło finansowania: HQGRPHWULXPWKHUHDUHDOVRRWKHUQXPHURXVFRPRUELGLWLHVWKDW Praca nie była finansowana przez żadną instytucję naukowo-badawczą, QHHG WR EH DGGUHVVHG LQ ZRPHQ WU\LQJ WR DFKLHYH SUHJQDQF\ stowarzyszenie ani inny podmiot, autorzy nie otrzymali żadnego grantu. (QGRPHWULDO SRO\SV VXEPXFRXV P\RPDV DQG DGKHVLRQV GR LQÀXHQFH WKH IHFXQGDELOLW\ 7KH\ SUHVHQW QRW RQO\ D SK\VLFDO Konflikt interesów: EDUULHUIRUHPEU\RLPSODQWDWLRQEXWWKHUHLVDOVRDPSOHHYLGHQFH Autorzy nie zgłaszają konfliktu interesów oraz nie otrzymali żadnego wynagrodzenia związanego z powstawaniem pracy. WKDW WKH SUHVHQFH RI P\RPDV RU SRO\SV GRHV LQGHHG FKDQJH HQGRPHWULDOUHFHSWLYLW\DWWKHPROHFXODUOHYHO>@ $OVR HQGRPHWULRVLV LV D GLVHDVH WKDW LV DVVRFLDWHG ZLWK GHFUHDVHG DELOLW\ WR DFKLHYH SUHJQDQF\ $SDUW IURP SRRUHU UHVXOWVLQRYXODWLRQLQGXFWLRQIRUPDWLRQRIDGKHVLRQVWKDWEORFN WKH )DOORSLDQ WXEHV DOWHUDWLRQV RI WKH SHOYLF KRUPRQDO DQG References LPPXQRORJLFDOVWDWXVWKDWDIIHFWWKHIHUWLOLW\HQGRPHWULRVLVDOVR 1. Zegers-Hochschild F, Adamson GD, De Mouzon J, [et al.]. The International Committee for DIIHFWVWKHHXWRSLFHQGRPHWULXP>@,WPD\H[SODLQZK\LQ Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization VRPHZRPHQZLWKPLQLPDOHQGRPHWULRVLVDPDUNHGO\GHFUHDVHG (WHO) Revised Glossary on ART Terminology, 2009. Hum Reprod. 2009, 24, 2683–2687. IHUWLOLW\SRWHQWLDOLVREVHUYHG>@ 2. Smith C, Grimm M, Schwegel M. Treatment of infertility in women. J Ann Pharm Assoc. 2012, 52 (4),27–42. 3. De Mouzon J, Goossens V, Bhattacharya S, [et al.]. 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152 © Polskie Towarzystwo Ginekologiczne Nr 2/2014 +MRIOSP4SP 46%')43+0Á(3;) ginekologia

Mateusz Mikołajczyk, Jana Skrzypczak. Endometrial receptivity – can it be diagnosed and controlled? And why does it matter?

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