December 1, 2020 Part I: General Information Name

Curriculum Vitae

Date Prepared: December 1, 2020 Part I: General Information Name: BRADFORD CLARK DICKERSON Office Address: Massachusetts General Hospital Frontotemporal Disorders Unit 149 13th, Suite 10.004 Charlestown, MA 02129 United States

Phone: (617) 726-6201 Email: [email protected] FAX: (617) 726-5760 Place of Birth: Richmond, MO

Education

08/86-5/90 B.S. Biomedical Engineering Southern Methodist University 08/94-05/99 M.D. Medicine University of Illinois 07/03-05/05 M.M.Sc. Clinical Investigation Harvard Medical School/Massachusetts Institute of Technology Postdoctoral Training

07/99-06/00 Intern Medicine Brigham and Women’s Hospital 07/00-06/02 Resident Neurology Partners (MGH and BWH) 07/02-06/03 Chief Resident Neurology Partners (MGH and BWH) 07/02-06/03 Research Fellow Neuroimaging Gerontology Research Unit & Martinos Imaging Center, Massachusetts General Hospital (Marilyn Albert, Bruce Rosen) 07/03-06/05 Clinical Fellow Cognitive and Behavioral Brigham and Women’s Neurology Hospital (Kirk Daffner) Faculty Academic Appointments

07/03-09/05 Instructor Neurology Harvard Medical School, Boston, MA 10/05-11/08 Assistant Professor Neurology Harvard Medical School, Boston, MA 12/08-04/20 Associate Professor Neurology Harvard Medical School, 1

Boston, MA 5/1/2020- Professor Neurology Harvard Medical School, present Boston, MA Appointments at Hospitals/Affiliated Institutions

07/03-06/12 Associate Neurologist Neurology Brigham and Women’s Hospital, Boston, MA 07/03-06/12 Assistant in Neurology Neurology Massachusetts General Hospital, Boston, MA 07/05- Affiliated Faculty Martinos Center for Biomedical Massachusetts General present Imaging Hospital, Boston, MA 10/08- Director Frontotemporal Disorders Unit Massachusetts General present Hospital, Boston, MA 07/12- Associate Neurologist Neurology Massachusetts General present Hospital, Boston, MA 07/12- Tommy Rickles Neurology Massachusetts General present Endowed Chair in Hospital, Boston, MA Primary Progressive Aphasia 07/15- Director Center for Translational Brain Massachusetts General present Mapping Hospital, Boston, MA

11/20- Psychiatrist Psychiatry Massachusetts General present Hospital, Boston, MA Other Professional Positions

10/90-10/92 Program Specialist National Alzheimer’s Association, Medical and Scientific Affairs Division, Chicago, IL 10/92-07/94 Manager National Alzheimer’s Association, Medical and Scientific Affairs Division, Chicago, IL 07/10-03/15 Member Scientific Advisory Council, Forum Pharmaceuticals, Waltham, MA 09/12-05/17 Member Scientific Advisory Board, Piramal Inc., Boston, MA 05/14-03/18 Member Data Safety Monitoring Board, Merck Inc., Philadelphia, PA 10/15-05/16 Member Scientific Advisory Board, Lilly Inc., Indianapolis, IN 10/15-05/19 Member Scientific Advisory Board, Biogen Inc. Boston, MA 10/19- Member Scientific Advisory Board, Arkuda Inc., present Boston, MA (10 hours per year) 08/20- Member Scientific Advisory Board, Acadia Inc., San present Diego, CA (10 hours per year)

Major Administrative Leadership Positions

Local 10/04- Member (2004-2016) MA/NH Alzheimer’s Association Chapter present Vice Chair (2016-2018) Medical and Scientific Advisory Council, Chair (2018-present) Waltham, MA (20 hours per year) 07/05-06/15 Director of Clinical Applications MGH Morphometry Analysis Center, Massachusetts General Hospital, Boston, MA 10/05-09/15 Co-Director Neuroimaging Group, Gerontology Research Unit and Alzheimer’s Disease Research Center, Massachusetts General Hospital, Boston, MA 09/07- Co-Director MGH FTD Unit Clinical-research present fellowship in Speech-Language Pathology (we have trained 6 fellows and 6 students) 09/10-10/15 Co-Director Center for Neural Systems Investigation, Massachusetts General Hospital, Boston, MA 05/11- Course Co-director Annual Harvard Medical School Dementia present Course (3.5 day course granting about 30 CME credits with about 300 attendees) 07/14- Co-Director Imaging Biomarkers Unit, MGH Clinical present Research Program, Massachusetts General Hospital, Boston, MA 10/14- Course Director MGH FTD Unit Rounds (quarterly 1 hour present case conference granting CME credit with about 35-40 attendees) 10/15- Director Center for Translational Brain Mapping, present MGH, Boston, MA 07/15-06/20 Co-Director McLean/MGH Fellowship in Behavioral Neurology and Neuropsychiatry 09/16- Co-Director MGH FTD Unit Clinical-research present fellowship in Neuropsychology (we have trained 2 fellows and 3 students) 04/17- Core Leader Neuroimaging Core, Massachusetts present Alzheimer’s Disease Research Center 07/20- Co-Director, Research Track Sydney Baer Endowed MGH Clinical present Fellowship in Behavioral Neurology and Neuropsychiatry Regional 09/05- Founding Chair, Organizing committee Charles River Association for Memory (along with Dan Schacter, John Gabrieli, (We have held 23 meetings with 80-120 and the late Howard Eichenbaum) attendees since 2005) MA/NH National 09/10- Member (2010-2019) Medical Advisory Council, Association for present Chair-elect (2020) Frontotemporal Degeneration, Philadelphia, PA (15 hours per year) 04/10-04/15 Course Director, “Primer of Behavioral American Academy of Neurology 3

Neurology” 04/15-04/19 Course Director, “The Neurology of Social American Academy of Neurology Behavior” 07/18- Co-Chair, Clinical Practice Guideline Alzheimer’s Association present Workgroup on the Diagnostic Evaluation of Alzheimer’s Disease and Related Disorders

Committee Service Local 1996-1999 James Scholar Program for Independent University of Illinois College of Medicine Study Advisory Committee 2001-2007 BWH Department of Internal Medicine Brigham and Women's Hospital Resident Selection Committee 2005-2007 Chair, Core data committee Brigham and Women's Hospital (Memory Disorders Unit) 2006- Executive Committee Alzheimer's Disease Research Center, Massachusetts General Hospital 2007-2009 Partners Brain Imaging Guidelines Partners Healthcare System Committee 2009-2010 Co-director, Harvard MBB Chalk Talk Harvard FAS Interdisciplinary Conference Series Mind/Brain/Behavior Initiative 2009- Interdisciplinary Mind/Brain/Behavior Harvard FAS standing committee 2012-2014 Member, Grants Management Task Force MGH Department of Neurology 2012- Member, Research Council MGH Department of Neurology 2012-2017 Numerous faculty search committees MGH Department of Neurology 2012-2015 Chair, External Advisory Committee Conte Center Grant P50 MH 94263-2; Prefrontal and Medial-Temporal Interactions in Memory, Howard Eichenbaum, PI National

07/16- Member, Standing Committee National Quality Forum, Washington, DC

International

2009-2011 Committee to revise and validate the International Committee on bvFTD diagnostic criteria for behavioral variant Diagnostic Criteria Frontotemporal Dementia

2017-2020 Conference Organizing Committee Alzheimer’s Association Alzheimer’s Vice Chair (2017-2018) Imaging Consortium Organizing Committee Chair (2018-2019) Immediate Past Chair (2019-2020; voting) 4

2019- Member Alzheimer’s Association International Conference Scientific Program Committee

2019- Member International Conference on Frontotemporal Dementia Conference Planning Committee

Professional Societies 1990- American Medical Writers Association Member 1995- American Medical Association Member 1996- Society for Neuroscience Member 1997- American Association for the Advancement Member of Science 1999- Massachusetts Medical Society Member 2002- American Academy of Neurology Member 2009-2015 Member, Behavioral Neurology Abstract Review Committee 2013-2016 Chair, Behavioral Neurology Topic Selection Committee 2018- Member, Behavioral Neurology Abstract Review Committee 2003- Organization for Human Brain Mapping Member 2004- Cognitive Neuroscience Society Member 2004- Society for Behavioral and Cognitive Member Neurology 2009- International Society for Primary Founding Member Progressive Aphasia 2010- International Society to Advance Alzheimer’s Research and Treatment Member 2017-2018 Vice Chair, Imaging Professional Interest Area 2018-2019 Chair, Imaging Professional Interest Area 2011- International Society for FTLD Founding Member 2012- American Neurological Association Member 2012- American Neuropsychiatric Association Member (ANPA) 2015-2017 Chair, ANPA Research Platform Committee

Grant Review Activities National 2004 Fidelity Research Foundation, Grant review Ad hoc Member committee 2004 Retirement Research Foundation, Grant Ad hoc Member review committee 2005 National Science Foundation, Grant review Ad hoc Member

committee 2006 Rush University, Chicago, IL, External Ad hoc Member grant review committee 2008 NIH Special Emphasis Panel ZRG1 HOP-V Ad hoc Member (02) M 2009 NIH Challenge Grant Review Panel #10 Ad hoc Member ZRG1 BDA-A (58) 2009 NIH Special Emphasis Panel ZRG1 PSE-E Ad hoc Member (02) M 2009 NIH Special Emphasis Panel ZAG1 ZIJ-9 Ad hoc Member (J4) 2010 NIH Neurological, Aging and Ad hoc member Musculoskeletal Epidemiology study section 2010 NIH Special Emphasis Panel ZRG1 BDCN Ad hoc Member T(02) 2010 NIH Special Emphasis Panel ZRG1 PSE-K Ad hoc Member (55) R 2011 NIH Special Emphasis Panel ZRG1 BBBP- Ad hoc Member E (53) R 2012 NIH Special Emphasis Panel ZMH1 ERB-L Ad hoc Member (04) S 2013 NIH Special Emphasis Panel ZMH1 ERB-X Ad hoc Member (04) S 2014 NIH Special Emphasis Panel Study Ad hoc Member Section,” Plasticity and Mechanisms of Cognitive Remediation in Older Adults” ZAG1 ZIJ-5 (A2) 2015 NIH Study Section, “Emerging Ad hoc Member Technologies and Training in Neurosciences” ETTN-H(55)

2015 NIH Special Emphasis Panel ZAG1 ZIJ-G Ad hoc Member (M1) 2015- Alzheimer’s Disease Drug Discovery Standing Member Foundation, Grant Review Committee 2018 NIH Special Emphasis Panel ZRG1 IFCN- Ad hoc Member B (55) S 2018 NIH Special Emphasis Panel ZAG1 ZIJ-9 Chair (A1) 2018 NIH Special Emphasis Panel ZRG1 BDCN- Ad hoc Member L (02) 2019 NIH Special Emphasis Panel ZRG1 BDCN- Ad hoc Member L02M 2019 ZRG1 PSE-V (55) R PAR Panel: Secondary Ad hoc Member Analyses of Existing Datasets in Heart, Lung and Blood Diseases and Sleep Disorders 6

2019-2020 NIH Continuous Submission Status (due to substantial grant review service) 2020- Alzheimer’s Drug Discovery Foundation Member (ADDF) and the Association for Frontotemporal Degeneration (AFTD) Joint Steering Committee (JSC) for Treat FTD Fund

International 2007-2010 Wellcome Trust for Biomedical Research, Standing Member Grant Review Committee 2008 Dutch Research Council, Grant Review Ad hoc Member Committee 2008-2015 Canadian Medical Research Council, Grant Standing Member Review Committee 2008 Health Research Board, Ireland, Grant Ad hoc Member Review Committee 2008 Alzheimer’s Society of the United Ad hoc Member Kingdom, Grant Review Committee 2010 Italian Ministry of Health External Grant Ad hoc Member Review Committee 2016-2017 Weston Brain Institute, Toronto, Canada, Standing Member Grant Review Committee

Editorial Activities Ad hoc Reviewer 2004-2008 Reviewer Hippocampus 2004- Reviewer Medical Physics 2004- Reviewer Brain 2004- Reviewer Neurobiology of Aging 2005- Reviewer Neuroimage 2005- Reviewer Achives of Psychiatry 2005- Reviewer Journal of Neuroimaging 2005- Reviewer Neurology 2005- Reviewer Journal of Neuroscience 2005- Reviewer Archives of Neurology 2005- Reviewer Human Brain Mapping 2006- Reviewer The Lancet 2006- Reviewer Annals of Neurology 2006- Reviewer Cerebral Cortex 2006- Alzheimer’s Disease and Associated Reviewer Disorders 2006- Journal of the International Reviewer Neuropsychological Society

2006- Reviewer Learning and Memory 2006- Reviewer Psychiatry Research: Neuroimaging 2006- Reviewer Brain Imaging and Behavior 2006- Reviewer Lancet Neurology 2007- Reviewer Journal of Neuroimaging 2007- Reviewer Journal of Neurology 2007- Reviewer Neuropsychologia 2008- Reviewer Brain Imaging and Behavior 2008- Reviewer Brain and Cognition 2008- Reviewer CNS Spectrums 2008- Reviewer Radiology 2008- Reviewer Brain Research 2008-2015 Reviewer Cortex 2009- Reviewer Neurorehabilitation & Neural Repair 2010- Reviewer Biological Psychiatry 2011- Reviewer New England Journal of Medicine 2011- Reviewer Archives of Gerontology and Geriatrics 2011- Reviewer Science Translational Medicine 2011- Reviewer Neuron 2011- Proceedings of the National Academy of Reviewer Sciences 2013- Reviewer Brain and Language 2014- Reviewer Nature Neuroscience

Other Editorial Roles 2007- Member, Editorial Board Frontiers in Neuroscience 2008- Member, Editorial Board Hippocampus 2011- Member, Editorial Board Neurodegenerative Disease Management 2015-2016 Associate Editor Neuroimage: Clinical 2015- Section Editor, Behavioral Neurology Cortex 2016-2020 Editor In-Chief Neuroimage: Clinical 2016- Alzheimer’s & Dementia: Diagnosis, Senior Associate Editor Assessment, and Disease Management

Honors and Prizes

1995-1999 James Scholar Program for Independent U. Of Illinois Col. Of Medicine Study (research conducted in Morrell lab, Rush University) 1995 Walter Rice Craig Summer Research U. Of Illinois Col. Of Medicine Fellowship (conducted in lab of W.T. Greenough) 1996 Honorable Mention, Student Research Day U. Of Illinois Col. Of Medicine 1996-1997 Rush University Scholars Fellowship (F & Rush University, Chicago IL L Morrell lab)

1997 Second place in Sigma Xi session of Rush Universit, Chicago IL research forum 1998 Alpha Omega Alpha U. Of Illinois Col. Of Medicine 1999 David M. Olkon Honors Scholarship U. Of Illinois Col. Of Medicine 2001 Outstanding Resident Teacher in Harvard Medical School Neurology 2003 Partners in Excellence Award (Chief Harvard/Partners Neurology Program Residents) 2003-2005 Clinical Investigator Training Program Harvard Medical School 2005 Mentor of the Year Award Harvard/Partners Neurology Residency Training Program 2005 Visiting professorship ADRC, Department of Neurology, 2007 MGH Scientific Advisory Committee Washington University, St. Louis, MO Poster of Distinction Award Massachusetts General Hospital 2013 Norman Geschwind Award in Behavioral American Academy of Neurology Neurology 2014 Honorable Mention, Annual Award for Schwartz Center, Boston, MA Compassionate Care 2017 Visiting professorship in honor of Drs. Department of Neurology, Rush University Frank and Leyla deToledo-Morrell School of Medicine, Chicago, IL

2018 Visiting professorship ADRC, Department of Neurology, University of Michigan, Ann Arbor, MI 2018 Visiting professorship Western Psychiatric Institute, University of Pittsburgh, Pittsburgh, PA

Report of Funded and Unfunded Projects Funding Information Past

2002-2007 Neuroimaging And Neuropsychological Studies Of Patients With Memory Problems P01 AG04953 Co-Investigator (P.I: Marilyn Albert, MGH) 2003-2005 Psychophysical and fMRI studies of the effect of the cholinesterase inhibitor galanthamine on visual perceptual learning Janssen #210109 PI (individual research project, investigator initiated) 2003-2008 Structural-functional MRI Studies of Memory in MCI & AD K23 AG22509 PI 2004-2006 Development and analysis of automated region of interest identification for MRI: An MRI reliability and validity study Pfizer #A9001128 PI (individual research project, investigator initiated) 2005-2008 Longitudinal MRI Morphometric Methods Analysis

Pfizer #219340 PI (individual research project, investigator initiated) 2006-2011 Evolution of memory-related fMRI activation over the course of MCI and AD R01 AG027435 Co-Investigator (PI Reisa Sperling, MGH) 2006-2007 High-resolution MRI of brain function & structure in aging & MCI: A pilot study NIA ADRC Pilot grant PI 2007-2009 Ultra-high resolution MRI of medial temporal lobe in MCI: A pilot study Alzheimer’s Association NIRG-07-58852 PI 2007-2012 Medial temporal lobe subregions in aging, MCI and AD: Structural and functional MRI R01 AG029411 PI 2008-2010 Ultrahigh-resolution MRI in vivo and ex vivo MRI of human medial temporal lobe R21 AG029840 PI 2008-2013 Small vessel disease and beta-amyloid deposition in mildly impaired cognition R01 NS062028 Co-Investigator (PI: Deborah Blacker, MGH) 2010-2013 Biomarkers for Neurodegenerative Dementias Alzheimer’s Association IIRG-09-133560 PI 2012-2013 4-Repeat Tau Neuroimaging Initiative Foundation (anonymous) MGH Site PI (Overall PI: Adam Boxer, UCSF) 2010-2015 Impact of amyloid on the aging brain R01 AG036694 Co-investigator (PI: Reisa Sperling, MGH) 2010-2015 Neuroimaging in Frontotemporal Degeneration R01 AG0323065 MGH Site PI (Overall PI: Howard Rosen, UCSF) 2011-2015 Automated segmentation of subregions of the medial temporal lobe in in vivo MRI R01 EB013565 Co-investigator (PI: Koen van Leemput, MGH) 2012-2015 Large-scale language networks: Topography and selective degeneration R21 NS077059 PI (Contact PI of MPI grant with Nikos Makris, MGH) 2012-2015 Social cognitive impairment in frontotemporal degeneration and schizophrenia R21 MH 097094 PI (Contact PI of MPI grant with Daphne Holt, MGH) 2013-2016 Pilot study of preclinical and prodromal frontotemporal degeneration R21 NS084156 PI 2013-2016 Imaging biomarkers of the FTD-ALS spectrum R21 NS079905 PI (Contact PI of MPI grant with Nikos Makris, MGH)

2014-2016 Autosomal dominant FTLD tauopathy patient-specific stem cell models R21 NS085487 PI (Contact PI of MPI grant with Steve Haggarty, MGH) 2013-2017 MR-assisted PET data optimization for neuroimaging studies R01 EB014894 Co-investigator (PI: Ciprian Catana, MGH) 2016-2018 Tau imaging in atypical AD NIH R21 AG051987 PI (Dickerson & McGinnis, Co-PIs) 2012-2018 Affective salience and memory in normal aging NIH R01 AG030311 PI $1,897,580 (Feldman-Barrett/Dickerson, Co-PIs) To investigate the neural structural and functional substrates of age-related changes in affective reactivity and interoceptive sensitivity. Longitudinal Early-onset Alzheimer’s Disease Consortium Study (LEADS) 2017-2018 NIH R56 AG057195 PI $1,250,000 (Apostolova, Dickerson, Rabinovici, Carillo, Co-PIs) To begin to develop the infrastructure and initial data collection for a 14-site study of young onset AD (Dickerson MRI Core Lead). Massachusetts Alzheimer’s Disease Research Center 2014-2019 NIH P01 AG005134 Neuroimaging Core Leader (PI: Brad Hyman, MGH) To lead the neuroimaging core of the ADRC. FTLD Clinical Research Consortium 2014-2019 NIH U01 AG045390 MGH Site PI (PIs: Brad Boeve (Mayo) & Adam Boxer (UCSF), Co-PIs) To develop a clinical research network to study a large sample of people with Frontotemporal Lobar Degeneration, aiming to develop natural history clinical and biomarker data to support trial design. Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) 2014-2019 NIH R01 AG045390 MGH Site PI $1,021,508 TDC MGH (PIs: Brad Boeve (Mayo) & Howard Rosen (UCSF), Co-PIs) To develop the first multicenter North American consortium studying biomarkers of preclinical and prodromal genetic FTD.

Neuromodulation of memory and language networks in Alzheimer’s Disease 2017-2020 NIH R21 AG056958 PI $275,000 TDC MGH (Dickerson, Camprodon, Eldaief, Co-PIs all at MGH) To investigate the effects of transcranial magnetic stimulation on neural network function in AD.

Current

2015-2024 Impact of amyloid on the aging brain (second funding cycle) NIH R01 AG036694 Co-Investigator (PI: Reisa Sperling, MGH) To compare memory-related brain structure and function in older adults with & without brain 11

amyloid. 2015-2021 Neural and cognitive changes associated with mindfulness training in older adults NIH R01 AG048351 PI $2,298,139 TDC MGH (Dickerson & Lazar, Co-PIs both at MGH) To test whether mindfulness-based stress reduction meditation training can promote resilient neural structure and function and cognition in cognitively intact older adults. 2016-2021 4-Repeat tau neuroimaging initiative NIH R01 AG038791 MGH Site PI $1,536,027 TDC MGH (PI: Adam Boxer, UCSF) To develop longitudinal clinical, imaging, and biomarker data for PSP and CBD. 2016-2021 Connectomic imaging in familial and sporadic FTLD NIH U01 AG052943 MGH Site PI $625,510 TDC MGH (PIs: Murray Grossman & Maria Luisa Gorno- Tempini, U Penn & UCSF) To investigate the value of high resolution DTI MRI data in familial and sporadic FTLD. 2016-2021 Imaging tau, amyloid, and neurodegeneration in Primary Progressive Aphasia NIH R01 DC014296 PI $2,499,995 TDC MGH (Dickerson & Johnson, Co-PIs both at MGH) To investigate tau and amyloid pet imaging in patients with primary progressive aphasia. 2017-2021 Exploring the role of inflammation in long-term cognitive decline following surgery and delirium Alzheimer’s Drug Discovery Foundation MGH Site PI $479, 356 TDC MGH (Inouye, PI) To investigate imaging & fluid biomarkers of inflammation in older adults with delirium. 2017-2022 The aging brain under general anesthesia: Neurophysiology, Neuroimaging biomarkers of aging and Alzheimer’s disease, and post-operative cognitive outcomes NIH R01 AG056015 PI $2,498,755 TDC MGH (Purdon, Dickerson, & Brown, Co-PIs all at MGH) To investigate differences between older adults with or without elevated brain amyloid with regard to physiologic measures before and during general anesthesia. 2017-2022 Noninvasive low-cost biomarkers for preclinical diagnosis and longitudinal tracking of Alzheimer’s disease using sleep and resting state EEG NIH R01 AG054081 PI $2,499,945 TDC MGH (Purdon, Dickerson, & Prerau, Co-PIs all at MGH) To investigate differences between older adults with or without elevated brain amyloid with regard to physiologic measures of resting state brain function during wakefulness and sleep. 2017-2022 Affect Regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology NIH R01 MH113234 PI $1,081,471 TDC MGH (Barrett, Dickerson, Isaacowitz, Co-PIs; Barrett & Dickerson at MGH) To investigate differences between older adults with or without elevated brain amyloid with regard to autonomic psychophysiology, affective function, and and measures of brain structure and function. 2018-2021 Biopsychosocial mechanisms of superaging NIH R56 AG058745 PI $498,053 TDC MGH (Barrett & Dickerson, Co-PIs both at MGH)

To plan and pilot measures for a behavioral and MRI study of superaging compared to typical aging. 2018-2023 Longitudinal Early-onset Alzheimer’s Disease Consortium Study (LEADS) NIH U01 AG057195 PI $1,561,920 TDC MGH (Apostolova, Dickerson, Rabinovici, Carillo, Co-PIs) To run a 15-site study of natural history, psychometrics, imaging, and fluid biomarkers of young onset AD (Dr. Dickerson is MRI Core Lead; MGH is also a clinical site). 2018-2023 A video intervention to improve decision making in early-onset dementia caregivers NIH R01 AG0061968 PI $1,750,000 TDC MGH (Dickerson & Volandes, Co-PIs both at MGH) To investigate the utility of a video educational intervention vs. narrative education in improving care-related decision-making in caregivers of patients with early-onset dementia. 2018-2023 Delirium, dementia, and the vulnerable brain: An integrated approach NIH P01 AG031720 Project 3 Leader $342,075 TDC MGH (Inouye, PI) To investigate the phenomenology and mechanisms of delirium, post-operative cognitive decline and dementia. Dr. Dickerson is the leader of Project 3 examining neuroimaging. 2019-2024 Massachusetts Alzheimer’s Disease Research Center NIH P30 AG062421 Imaging Core Leader $728,150 (Hyman, PI) To provide infrastructure to support Alzheimer research, including clinical, neuropathological, neuroradiological, biomarker, statistics, and administrative cores. 2019-2021 Resilient together; Developing a resiliency skills program for dyads of patients with young onset dementia and their family caregivers NIH R21 NR017979 02S1 Co-Investigator $209,995 TDC MGH (Vranceanu, PI) To develop and pilot a psychoeducational intervention with recently-diagnosed patients with young-onset dementia and their spouses 2019-2024 Impact of depression on Alzheimer's disease: Prenatal immune origins and shared impact of sex NIH R01 AG067019 Co-Investigator $1,492,211 TDC MGH (Goldstein, PI) To investigate cerebral amyloid and cortical atrophy in middle-aged adults followed deeply and longitudinally since they were in utero

Training Grants and Mentored Trainee Grants 2017-2022 Neuroimaging biomarkers of symptom severity, adverse life events and prognosis in motor functional neurological disorders NIH K23 MH111983 Primary Mentor $925,995 (PI: David Perez, MD) 2018-2023 Transcranial magnetic stimulation and modulation of large-scale neural networksin neurodegenerative disease NIH K23 DC016912 Primary Mentor $935,995 (PI: Alexandra Touroutoglou, PhD) 2019-2020 TMS in preclinical and prodromal AD: Modulation of brain networks and memory 13

NIH K01 AG059894 Primary Mentor $367,000 (PI: Jessica Collins, PhD) 2020-2025 Dissociating the mechanisms of tau PET and cortical atrophy underlying memory deficits in typical and atypical prodromal AD NIH K23 AG065450 Primary Mentor $876,000 (PI: Deepti Putcha, PhD)

Report of Local Teaching and Training Teaching of Students in Courses 2003 Preceptor, Harvard Behavioral Neurology Harvard Medical School Elective, Responsibility: Supervise the elective Special Accomplishments: I supervised experience of Harvard Medical Students Alice Chen-Plotkin in designing and with special interest in behavioral executing this elective which received neurology credit as an elective. 2004- Invited Lecturer, HST 583: Functional Harvard Medical School Magnetic Resonance Imaging: Data Responsibility: Have given 3-5 lectures in Acquisition and Analysis this HST course in 2004, 2006, 2008, 2010, 2012, 2015, 2017, 2019 and plan to do so again every other year when the course is offered. 2010 Invited Lecturer, HST 563: Imaging Harvard Medical School Biophysics and Clinical Applications Responsibility: Gave one lecture in this course on MRI/PET imaging applications to neurologic disorders 2010- Invited Lecturer, HMS Neurobiology 200 Harvard Medical School Responsibility: Have given one lecture in this course on Memory Disorders every year since 2010 2010- Invited Lecturer, HST 130: Introduction to Harvard Medical School Neurobiology Responsibility: Have given one lecture in this course on Memory Disorders every year since 2010 2012-2013 Invited Lecturer, HMS IN757.0 Human Harvard Medical School Systems Responsibility: Gave one lecture in this course on Memory Disorders (2012, 2013)

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 2003- MGH Psychology Post-Doctoral Seminar 1 lecture/year Series (post-doctoral fellows in neuropsychology)

Clinical Supervisory and Training Responsibilities

2009- Precept/supervise clinical evaluations I have supervised up to 3 behavioral performed by behavioral neurology fellows with weekly clinics in neurology/neuropsychiatry fellows MGH FTD Unit (currently 2 fellows)

I supervised 1-2 month-long rotations by 2004-2015 Behavioral Neurology Elective residents in behavioral neurology for 8 of (Residents) the years in this interval

2009-2020 McLean/MGH Behavioral neurology 1 fellow supervised one morning per week and neuropsychiatry fellows in clinic; some years the fellow also joins me 1-2 additional days per week for research 2010- MGH Behavioral neurology and 1-2 fellows supervised one afternoon per neuropsychiatry fellows week in clinic; some years the fellows also joins me 1-2 additional days per week for research

Laboratory and Other Research Supervisory and Training Responsibilities

2004- I have supervised 1-4 Supervising trainees’ laboratory residents/fellows/post-docs during extended experience, Massachusetts General laboratory electives depending on interest Hospital and availability of residents/fellows Formally Mentored Medical and Graduate Students 2004- Rahul Desikan, M.D., BU MD, PhD student (formal named external advisor on 2006 Ph.D. dissertation committee); now deceased but was Associate Professor of Radiology at UCSF 2005- Rebecca Melrose, Ph.D. BU psychology graduate student (formal named external 2007 advisor on dissertation committee); currently Research Psychologist, UCLA 2006- Lindsay Barker, Ph.D. Suffolk University graduate student in psychology (secondary 2007 mentor on dissertation research project): Currently psychologist, Brigham & Women’s/MGH 2006- Frida Polli, Ph.D. Suffolk University graduate student in psychology (secondary 2007 mentor on dissertation research project): Currently head of her own startup company developing cognitive testing software 2008 Aaron Shmookler Formal mentoring during AFAR Summer Medical Student research award: Currently medical resident, U of Toledo OH 2008- Kimiko Domoto-Reilly, Chair, Master’s Degree Committee, Harvard Medical School 2010 M.D., M.MSc. Master’s Degree Clinical Investigator Training Program Committee; currently Assistant Professor of Neurology at U Washington, Seattle, WA 2009-12 Yakeel Quiroz, Ph.D. Formal Advisor on dissertation committee, Boston University Department of Psychology; currently Associate Professor of Psychiatry, MGH 15

2010-13 Kevin Bickart, M.D., Chair, dissertation committee, Department of Anatomy and Ph.D. Neurobiology, Boston University; currently behavioral neurology fellow at UCLA 2010-12 Sarah George, Ph.D. Formal external advisor on dissertation committee, Rush University Medical School; current status unknown 2013-16 Joseph Keller, Ph.D. Chair, dissertation committee, MIT Brain & Cognitive Sciences Program 2014- Claire Cordella, B.S. Chair, dissertation committee, HST Speech and Hearing 2019 Biosciences and Technology graduate program; I co-supervised her clinical SLP fellowship; she is currently a post-doc at Boston University 2014-17 Kevin Chen, Ph.D. Member, dissertation committee, HST graduate student in Medical Engineering and Medical Physics Program; I was co- mentor on dissertation project; current status unknown 2014-17 Angela She, Ph.D. Member, dissertation committee, HST graduate student in Chemical Biology Program, I was co-mentor on dissertation project; current status unknown 2015-19 Jiahe Zhang, Ph.D. Member, dissertation committee, Northeastern University Department of Psychology; now post-doc at Northeastern 2018- Jeanne Gallee, B.S. Current HST Speech and Hearing Biosciences and Technology graduate student 2019- Alex He, B.S. Current HST Medical Engineering and Medical Physics graduate student 2019- Diane Chan, M.D. Current Harvard Catalyst KL2 Medical Research Investigator Training Program primary mentee

Formally Supervised Trainees 2004- Saul Miller, Ph.D. Research assistant (I mentored him on 3 first author papers 2007 prior to his matriculation into graduate school); currently Assistant Professor, Department of Psychology, University of Kentucky 2005- Keith Vossel, M.D. Neurology Resident (extended research mentoring during 2007 residency): currently Associate Adjunct Professor, Department of Neurology, UCSF 2005- Richard King, M.D., Neurology Resident (extended research mentoring during 2007 Ph.D. residency): currently Associate Professor of Neurology, Univ of Utah 2006 David Koh High school student, participant in Dickerson Lab Summer Brain Camp: Currently MIT graduate student 2007 Min Deng AFAR Summer Medical Student research award (primary mentor); current status unknown 2007 Christine Lai High school student, participant in Summer Brain Camp; current status unknown 2007- Daisy Sapolsky Clinical fellow in speech pathology: Currently senior staff 2008 Speech Pathologist, MGH 2008- Liang Wang, M.D. Radiologist, post-doctoral research fellow: Currently Research 16

2011 Scientist, Department of Neurology, Washington University School of Medicine 2008 Dina Gozman Medical student, participant in Summer Brain Camp, Ohio State University Coll Medicine; current status unknown 2008- Ugwechi Amadi Undergraduate Student participant in Summer Brain Camp, 2009 MIT; current status unknown 2008- Kimiko Domoto-Reilly, Behavioral Neurology fellow, MGH (primary mentor on her 2014 M.D. work in the HST MPTCI Clinical Investigation program): Imaging biomarkers of Frontotemporal dementia: She was appointed to junior faculty (Instructor) in the HMS Dept Neurology in 2012; currently Assistant Professor at University of Washington, Seattle WA 2008- Scott McGinnis, M.D. Assistant Professor in Neurology, HMS (I have been Scott’s faculty mentor, including helping him obtain a Pilot ADRC Grant, an R21, and ongoing research) 2008- Stephane Poulin, M.D. Post-doctoral neuropsychiatry research fellow in my lab: 2010 Anatomic correlates of neuropsychiatric symptoms in dementia; Currently Associate Professor, Department of Psychiatry and Neurosciences, Faculty of medicine, University Laval, Quebec City, Quebec 2008-09 Lucille Pellerin, M.D. Post-doctoral research fellow: Face processing in dementia; Caregiver burden in dementia; Currently Lecturer in Internal Medicine in Paris 2009-12 Belen Pascual, Ph.D. Psychologist, post-doctoral research fellow: Large-scale brain networks for social cognition in health and dementia; Currently Research Psychologist, Houston Hospital, Houston TX 2009- Alex Touroutoglou, Ph.D. Post-doc research fellow; I was primary mentor on her post- doc and she was recently promoted to Assistant Professor of Neurology at MGH/HMS still under my primary mentorship with a K23 award 2010-12 Kristen Lindquist, Ph.D. Post-doctoral psychology research fellow (awarded Harvard MBB fellowship under my mentorship): Emotional processing abnormalities in Frontotemporal Dementia; currently Assistant Professor, Department of Psychology, University of North Carolina 2010-11 Priya Doerga, B.S. Holland medical student research master’s thesis project, VU University, Amsterdam: A method for segmenting amygdala subnuclei; current status unknown 2010-11 Pascal Lie, B.S. Holland medical student research master’s thesis project, VU University, Amsterdam: A method for segmenting hippocampal subfields; current status unknown 2010-11 Jessica Pan Brown University senior undergraduate student honor’s thesis project: A method for parcellating the orbitofrontal cortex; currently Emory University neuropsychologist 2012-13 Mandana Modirrousta, Research fellow, MGH: (Neuropsychiatry of PPA and FTD); M.D. Currently staff neuropsychiatrist, Montreal 2012-14 Mark Eldaief, M.D. Behavioral Neurology clinical and research fellow, MGH FTD Unit; Currently Assistant Professor of Neurology at MGH 17

2012-13 Joan Camprodon, M.D., Neuropsychiatry clinical fellow, MGH FTD Unit; Currently Ph.D. Chief of Neuropsychiatry, MGH 2012-13 Mia Minen, M.D. Neuropsychiatry clinical fellow, MGH; Currently Assistant Professor, NYU 2012-14 Simon Ducharme, M.D. Neuropsychiatry clinical research fellow, MGH FTD Unit; Currently Assistant Professor, McGill University & Montreal Neurological Institute 2013-14 Rani Sarkis, M.D. Neuropsychiatry clinical fellow, MGH FTD Unit; Currently Instructor in Neurology, HMS/BWH 2013-16 Elena Ratti, M.D. Neurology research fellow, MGH FTD Unit and MGH ALS Unit; co-mentor of her work in the HST MPTCI Clinical Investigation program; currently Project Director at Biogen 2013-17 Chenjie Xia, M.D. Neurology research fellow, MGH FTD Unit; currently Assistant Professor of Neurology, University of Montreal 2013-14 James O’Donovan, B.S. Harvard Kennedy Scholar medical student; currently medical student, Newcastle University 2014-15 Sara Mitchell, M.D. Neurology clinical and research fellow, MGH FTD Unit; Currently Assistant Professor of Neurology, University of Toronto 2014- Jessica Collins, Ph.D. Research fellow, MGH FTD Unit; currently Instructor in 2020 Neurology, MGH; recently awarded K01 on which I was primary mentor; took an imaging scientist position at Biogen 2014-15 Tamar Gefen, Ph.D. Research fellow in neuropsychology, MGH FTD Unit; Currently Assistant Professor of Psychiatry, Northwestern University, Chicago, IL 2014-15 Megan Quimby, MS, Speech and language pathology fellow, MGH FTD Unit; CCC-SLP Currently Director of Speech-Language Pathology Program in MGH FTD Unit 2014- David Perez, M.D. Instructor in Neurology; I was primary mentor of his work in the HST MPTCI Clinical Investigation program and am primary mentor on his K23; currently Assistant Professor of Neurology, MGH/HMS 2014- Tal Kenet, Ph.D. Assistant Professor in Neurology under my formal faculty mentorship; promoted to Associate Professor 2015- Jaya Padmanabhan, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit, 2018 currently Instructor in Psychiatry, HMS 2015-16 Alessandro Biffi, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit; currently Instructor in Neurology, HMS 2015-16 Joel Salinas, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit; currently Instructor in Neurology, HMS 2015-17 Ryan Darby, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit; currently Assistant Professor of Neurology, Vanderbilt University 2015- Lee Richardson, MS Speech-language Pathology Clinical Fellow, MGH FTD Unit; 2018 Currently staff Speech-Language Pathologist, Lahey Clinic 2015-16 Bedia Samanci, M.D. Visiting neurology resident from the Medical University of Turkey (I mentored Dr. Samanci on an imaging research project in the MGH FTD Unit; she returned to her home 18

institution) 2015-16 Laura Veronelli, Ph.D. Visiting scholar neuropsychologist from the Department of Rehabilitation Sciences, Casa Cura Policlinico, Milan Italy (I mentored Dr. Veronelli on an imaging research project in the MGH FTD Unit; she returned to her home institution) 2015-16 Kate Adamczuk, Ph.D. Research fellow in cognitive and imaging neuroscience, MGH FTD Unit; currently working at Biospective 2015-16 Chunyan Luo, M.D. Visiting radiologist, MGH FTD Unit; current status unknown

2016-19 Christian Leyton, Ph.D. Research fellow in cognitive and imaging neuroscience, MGH FTD Unit; now at Frontier Research Unit in Sydney, Australia 2016- Deepti Putcha, Ph.D. Research fellow in neuropsychology and cognitive and imaging neuroscience, MGH FTD Unit; now Instructor in Psychiatry, MGH; K23 on which I am primary mentor recently was recently funded 2016-17 Saurabh Sharma, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2016-19 Annie Racine, Ph.D. Post-doctoral research fellow, MGH FTD Unit 2017-18 Adriana de Julio, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2017-18 Shan Siddiqi, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2018-20 Shalom Kim, M.S. Speech-language pathology clinical fellow, MGH FTD Unit; now licensed staff speech-language pathologist; matriculated into PhD program at Cambridge University, UK and funded by Bill Gates Foundation 2018-20 Neguine Rezaii, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit; received ANPA Young Investigator award for research conducted in my lab under my mentorship 2018-19 Amy Newhouse, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2018-19 Mahdi Razafsha, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2018- Sheena Dev, Ph.D. Neuropsychology clinical and research fellow, MGH FTD Unit 2019-20 Michael Kritzer-Crenan, Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit M.D. 2020- Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit 2020- Sylvia Josephy, M.D. Behavioral neurology/neuropsychiatry fellow, MGH FTD Unit David Kim, M.D.

Formal Teaching of Peers (e.g., CME and other continuing education courses) Those presentations below sponsored by 3rd parties/outside entitites are so noted and the sponsor(s) is (are) identified.

2005- Alzheimer’s Association Map Through the Maze I have given a one hour lecture Lecturer on dementias annually in this CME course for 40-50 attendees

2006 Harvard Annual Psychiatric Neuroscience Course: A 40 participants, Primer for Clinicians (Lecturer on the Neuroimaging 2 hours contact time 19

and the Neurobiology of AD)

2007 Dementia: A Comprehensive Update 250-300 participants, Lecturer on Frontotemporal Dementia 1 hour contact time 2007- Dementia: A Comprehensive Update (3-day Harvard 25-300 participants, CME Course) 1 hour contact time per year Lecturer on Neuroimaging in Dementia 2007- Harvard/MIT/MGH Martinos Center Short course on I give a one hour lecture in this multimodal neuroimaging annual course with 50-70 Lecturer participants 2008- Harvard/MIT/MGH Martinos Center fMRI course I give a one hour lecture in this Lecturer annual course with 50-70 participants 2011- Dementia: A Comprehensive Update (3 1/2-day 250-300 participants, Harvard CME Course) 10 hours contact time per day for Co-Director (I have co-directed this annual course and 3 1/2 days, continue to do so) 2011- MGH FTD Unit Rounds I direct a 1-hour MGH CME- Director accredited case conference series that takes place 6-8 times per year; 35-50 participants 200 participants, 2014- Head and Neck Radiology (3-day Harvard CME 1 hour contact time per year Course) Lecturer on Imaging of Dementia 2014- Neuropsychiatry (2-day Harvard CME Course) 250 participants, Lecturer on Frontotemporal Dementia 1 hour contact time per year 2014-2016 An update on neuroimaging in the diagnosis of 100-150 participants, 3 hours Alzheimer’s disease (3-hour CME course sponsored contact time, 10 sessions by Med Learning Group) 250 participants, 1 hour contact 2016- Neurorehabilitation (2-day Harvard CME Course) time per year Lecturer on Social Cognitive Function

Local Invited Presentations Those presentations below sponsored by 3rd parties/outside entitites are so noted and the sponsor(s) is (are) identified. 2004 Alzheimer’s Disease: Clinical and Research Update/Grand Rounds Spaulding Rehabilitation Hospital 2005 Early diagnosis of Alzheimer's disease: A missed opportunity/Grand Rounds Winchester Hospital 2006 Early detection of Alzheimer's disease: New opportunities/Grand Rounds Youville Hospital 2006 Advances in Alzheimer's Research and Treatment/Grand Rounds North Shore Medical Center (Union Hospital), Lynn, MA

2006 Advances in High-resolution MRI imaging: Clinical applications, Massachusetts General Hospital: Martinos Center Siemens Collaborative Roundtable

2007 Cortical structure and function in aging and Alzheimer's disease/Behavioral Neuroscience Rounds Brigham and Women's Hospital 2007 Cortical structure and function in aging and Alzheimer's disease/Grand Rounds Massachusetts General Hospital Department of Neurology 2008 Where does Alzheimer’s Disease begin in the brain: a paradigm shift. New insights from novel in vivo imaging and postmortem data 963rd meeting of the Boston Society of Neurology and Psychiatry 2004 Visual Memory and Alzheimer’s Disease, Massachusetts Institute of Technology Brain & Cognitive Sciences seminar series 2005 Memory-related medial temporal lobe activity in mild cognitive impairment: Testing the compensatory hypothesis, Boston University Center for Memory and Brain seminar series 2005 Anatomy and Physiology of Memory in Mild Cognitive Impairment, Boston University Alzheimer’s Disease Research Center seminar series 2005 Neural correlates of free recall: An event-related fMRI study, Harvard University Cognitive Psychology seminar series 2006 Medial temporal lobe function and structure: Aging, MCI, and Alzheimer's disease, Massachusetts Institute of Technology: Brain & Cognitive Sciences Corkin lab meeting 2006 Brain structure and function in very early Alzheimer_s disease: Insights from MRI of living humans, Boston University Alzheimer's Disease Research Center Seminar Series 2006 The cortical signature of Alzheimer's disease: Reliability and applications, Massachusetts General Hospital Gerontology Research Unit seminar series 2006 Computational challenges in measuring brain structure and function in aging, MCI, and AD, Massachusetts Institute of Technology 2007 Cortical structure and function in aging and Alzheimer's disease, Massachusetts General Hospital Martinos Center Brain Mapping Seminar 2007 Clinical prediction of cognitive decline: Use of CDR-SB and neuropsychological testing, Massachusetts General Hospital 2013 A 31 Year-Old Man with Personality Changes and Progressive Neurologic Decline, MGH Grant Rounds, New England Journal Clinicopathological Case Conference [Lead case presenter and discussant] 2014 Large-scale brain networks and neurodegenerative diseases: Insights from Frontotemporal Degeneration, Longwood Neurology Grand Rounds, Boston, MA [Invited Lecture] 2015 Imaging biomarkers of delirium, CEDARTREE Delirium week long course [Invited Lecturer in Boot Camp] 2016 Frontotemporal Dementia; MGH Grand Rounds, Palliative Care 2017 Large-scale human brain networks in aging and neurodegenerative disease, McLean Brain Imaging Seminar Series, Belmont, MA [Invited Lecture] 2017 Large-scale brain networks and neurodegenerative disease; MGH Grand Rounds, Neurology 2018 Dementia for the non-expert; The Partners Heathcare Aging Brain Symposium, Somerville, MA [Invited keynote lecture] 2019 Dementia comes in many forms: Learn how we make an early diagnosis and why it matters; MGH Dementia Care Collaborative [invited lecture] 2020 Fractionating memory into cognitive processes and brain networks: Insights from aging 21

and neurodegenerative disease; Boston University Neuroscience Grand Rounds [invited Grand Rounds lecture] 2020 Caring for the younger patient: Understanding early-onset and atypical dementia; Mass NAELA Elderlaw Institute XXVI [Invited keynote lecture] 2020 Social, affective, and cognitive functions and their impairments in neurodegenerative dementias; McLean Neuroscience Seminar Series [invited lecture] 2020 Fractionating Memory into Cognitive Processes and Brain Networks: From Neurodegenerative Disease to Normal Aging to Superaging; Massachusetts General Hospital Department of Neurology Grand Rounds [Invited Professorship Grand Rounds]

Report of Regional, National and International Invited Teaching and Presentations Those presentations below sponsored by 3rd parties/outside entitites are so noted and the sponsor(s) is (are) identified. Invited Presentations and Courses Regional 2006 Memory-related brain function and structure in aging, MCI, and AD, Grand Rounds, Brown University Department of Neurology, Providence, RI [Invited Lecture] 2008 Brain networks and memory dysfunction, Charles River Association for Memory Biannual Meeting plenary talk [Invited Lecture] 2009 The cortical signatures of neurodegenerative dementias, Bedford VA GRECC Grand Rounds [Invited Lecture] 2015 The human brain connectome and cognitive and affective function: Normal individual variability, aging, and neurodegeneration, Rhode Island Hospital Neurology Grand Rounds, Providence, RI [Invited Lecture] 2015 From genome to brain connectome to behavior: Normal individual variability, aging, and neurodegeneration, Tufts University Provost’s Series on Cognitive Aging, Medford, MA [Invited Lecture] 2016 Human Brain Networks Subserving Cognitive and Affective Function: Normal individual variability, aging, and neurodegeneration, Boston VA Brain Imaging Center Seminar Series, Boston, MA [Invited Lecture] 2017 Alzheimer’s disease: The journey to a diagnosis, Keynote lecture for Alzheimer’s Association Map Through the Maze annual meeting [Invited Lecture] 2019 23rd Charles River Association for Memory Keynote Lecture [Invited Lecture]

National 2004 Visual encoding in questionable Alzheimer's disease, Cognitive Neuroscience Grand Rounds, Johns Hopkins Hospital[Invited Lecture] 2005 Medial temporal lobe function and structure: Health, cognitive impairment, and Alzheimer’s disease, Washington University Alzheimer's Disease Research Center [Invited Lecture in conjunction with Visiting Professorship] 2006 MRI of Degenerative Diseases, lecture in AAN full-day course on Update on MRI: Techniques and Applications [Invited Lecture] 2007 Session co-chair, Functional Neuroimaging Scientific Session, AAN 2007 The cortical signature of Alzheimer's disease, University of Pittsburgh Alzheimer Center [Invited Lecture] 22

2007 The cortical signature of Alzheimer's disease: Abnormalities in the anatomy and activity of the cerebral cortex, Emory University Alzheimer Center [Invited Lecture] 2008 Functional MRI in Neurologic Disorders, lecture in AAN full-day course on Update on MRI: Techniques and Applications [Invited Lecture] 2008 Session Co-Chair, Learning and Memory Scientific Session, AAN

2008 Advances in the early diagnosis of Alzheimer's disease: Imaging biomarkers, Christ Hospital, Chicago, IL [Invited Lecture: Psychiatry Grand Rounds] 2008 Network dysfunction in Alzheimer’s disease, NIH Workshop on Epilepsy and Dementia [Invited Lecture] 2009 Memory systems of the brain, lecture in AAN half-day course on Primer of Cognitive Neurology [Invited Lecture] 2010 Quantitative Imaging as a Marker of Diagnosis and Progression of Neurodegenerative Diseases (Invited talk in Dr. Walter Koroshetz’s Future of Neuroscience conference at American Academy of Neurology meeting, Toronto, ON) 2010-2015 Overview of Memory Systems, AAN CME Course “Primer of Behavioral Neurology,” American Academy of Neurology annual meeting for 5 years in a row 2011 Alzheimer-signature MRI biomarker predicts likelihood of AD dementia in cognitively normal adults (Invited lecture in Dr. Ron Petersen’s Future of Neuroscience conference at American Academy of Neurology meeting, Honolulu, HI) 2011 Frontotemporal Degeneration: New Tools for Early Diagnosis and Monitoring Set the Stage For Treatment Trials, Association for FTD Annual Conference, Cambridge, MA [Invited lecture] 2011 Brain systems abnormalities underlying neurodegenerative disorders: From basic neuroscience to biomarkers, Annual UAB Neuroscience Symposium, Birmingham, Alabama [Invited lecture] 2012 Diagnostic considerations for FTD and related disorders, National FTD Treatment Study Group Meeting, Bethesda, MD [Invited lecture] 2012 Large-scale human neural systems subserving individual differences in social network size, Society for Social Neuroscience annual meeting, Washington, DC [Invited lecture] 2013 The cortical signatures of Alzheimer's disease and Frontotemporal Degeneration: Quantitative MRI biomarkers detectable prior to dementia, 12th annual MCI Symposium, Miami, FL [Invited lecture] 2013 Large-scale brain networks and cortical signatures of neurodegenerative diseases, AAN Annual Geschwind Award Lecture, Chicago, IL [Invited lecture] 2013 Neural systems subserving social behavior, lecture in AAN CME Course “Neurology of Social Behavior,” American Academy of Neurology annual meeting, Vancouver, BC, Canada [Invited lecture] 2013 Understanding the brain of the older adult: Cognitive and neural markers of aging, Alzheimer’s, and cerebrovascular disease, University of Illinois Center for Nutrition, Learning, and Memory annual symposium, Urbana, IL [Invited lecture] 2013 Large-scale brain networks and cortical signatures of neurodegenerative diseases, U Penn Neurology Grand Rounds, Philadelphia, PA [Invited lecture] 2013 Structural and functional MRI in Alzheimer’s disease: Windows into living anatomy and physiology, 3rd National Nantz Alzheimer’s Center Symposium, Houston, TX [Invited lecture] 2014 Large-scale brain networks: Individual difference in brain-behavior relationships and neurodegenerative diseases, Cognitive Neurology and Alzheimer’s Disease Center 23

Symposium, Northwestern University, Chicago, IL [Invited lecture] 2014 Tau PET Imaging in Alzheimer’s and Non-Alzheimer’s Dementias, Behavioral Neurology Special Interest Group, American Neurological Association, Baltimore, MD [Invited lecture] 2015 Organized ½ day session on non-AD forms of MCI and gave lecture “MCI of the FTLD type: Clinical Features and Imaging and Molecular Biomarkers”, 14th annual MCI Symposium, Miami, FL [Invited to be ½ day session organizer] 2015 Organized ½ day session on atypical AD and gave lecture “Overview of atypical AD”, American Neuropsychiatric Association annual meeting, Orlando, FL [Invited to be ½ day session organizer] 2015 Toward Imaging Tau Pathology In Vivo in FTLD, American Academy of Neurology platform session, Washington, DC [Invited lecture] 2016 Tau PET imaging in neurodegenerative diseases, 5th National Nantz Alzheimer’s Center Symposium, Houston, TX [Invited lecture] 2016 Molecular imaging in FTD clinical trials, National FTD Treatment Study Group Meeting, Bethesda, MD [Invited lecture] 2016 Memory abilities, systems, and deficits; lecture in AAN CME Course Primer of Behavioral Neurology, Vancouver, BC, Canada [Invited lecture] 2016-2019 Behavioral Processes and Brain Systems involved in Social Behavior, AAN CME Course “Neurology of Social Behavior,” American Academy of Neurology annual meeting Memory systems in aging and neurodegenerative disease, Morrell memorial lecture, Rush 2017 University Medical Center, Chicago, IL [Visiting professorship] Tau PET imaging in Neurodegenerative disease, ANA Interactive Lunch Workshop 2017 Large-Scale Brain Network Degeneration in Aging and Neurodegenerative Disease, University of Michigan Grand Rounds, Ann Arbor, MI [Invited lecture and visiting 2018 professorship] 2018 View from the epicenters of network-related neurodegeneration in FTD and AD, University of Pittsburgh Aging Brain Symposium, Pittsburgh, PA [Invited lecture and visiting professorship] 2018 Imaging biomarkers in the diagnosis of Alzheimer’s disease; Gerontological Society of America meeting, Boston, MA [Invited lecture in Biogen-sponsored lunch symposium] 2019 The promise and pitfalls of imaging biomarkers in the diagnostic evaluation of research participants; 17th annual MCI Symposium, Miami, FL [Invited lecture and session moderator] 2019 The Aging Brain: Large-Scale Brain Network Degeneration in Aging and Neurodegenerative Disease, Dallas Aging Brain Symposium, Dallas, TX [Invited lecture]

International 2004 Functional and Structural MRI in Questionable Alzheimer_s Disease: Relationships to Clinical Impairment and Future Decline, 9th International Conference on Alzheimer's Disease and Related Disorders[Invited Lecture] 2005 Functional MRI in Mild Cognitive Impairment: Relationships to Clinical Status and Risk of Dementia, Winter Conference on Neural Plasticity (Guadeloupe)[Invited Lecture] 2006 Functional neuroimaging of plasticity in neurological disorders, Winter Conference on Neural Plasticity (Barbados)[Invited Lecture] 2006 Invited Session Chair, Neuroplasticity in Recovery of Brain Function: Insights From Animals and Humans, Winter Conference on Neural Plasticity

2006 Functional neuroimaging of dementia, French Neurological Society, Centennial Celebration of Professor Alzheimer (Paris)[Invited Lecture] 2006 The cortical signature of Alzheimer’s disease: Quantitative measures of neocortical anatomy in living humans, University College of London, Centre for Neuroimaging Techniques[Invited Lecture] 2010 Quantitating Severity and Progression of Primary Progressive Aphasia, 7th International Conference on Frontotemporal Dementia, Indianapolis, IN, USA[Invited Lecture] 2011 The brain of the older adult: "Normal" aging and common age-related pathologies, International Anesthesia Research Society, Vancouver, BC, USA[Invited Lecture] 2011 Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults, International Conference on Alzheimer’s Disease, Toronto, Ontario, Canada [Invited lecture] 2013 Monitoring progression of PPA and bvFTD: Toward measures useful for clinical trials, 41st annual International Neuropsychological Society meeting, Kona, Hawaii, USA [Invited Lecture] 2013 Diagnosis of “The Other Dementias”: Not uncommon or necessarily isolated, Alzheimer’s Association International Primary Care Preconference, Boston, MA [Invited Lecture] 2013 Prodromal FTLD: Mild cognitive impairment clinical & imaging phenotypes of FTD, International Meeting on Familial FTLD Treatment Development, San Francisco, CA, USA [Invited Lecture] 2014 Neuroimaging biomarkers in clinical trials of neurodegenerative diseases, 2nd Clinical Trials Network Institute European Symposium, Venice, Italy [Invited Lecture] 2014 Imaging Tau Pathology in vivo in FTLD: Initial Experience with [18F] T807 PET, Alzheimer’s Association International Conference, Copenhagen, Denmark [Invited Lecture] 2014 Imaging Tau Pathology in vivo in FTLD: Initial Experience with [18F] T807 PET, 9th International Conference on Frontotemporal Dementia, Vancouver, BC, Canada [Invited Lecture] 2014 Treatment of FTLD spectrum disorders: Current possibilities, future directions, FTLD Clinic Inaugural International Symposium, Leuven, Belgium [Invited Lecture] 2014 Large-scale brain networks: individual differences, aging, and neurodegenerative diseases, 3rd International Meeting on Translational Imaging in AD/PD, Montreal, Quebec, Canada [Invited Lecture] 2015 Tau PET imaging in neurodegenerative dementias, International Psychogeriatrics Association, Berlin, Germany [Invited Lecture] 2016 The Human Brain Connectome and Cognitive and Affective Function: Normal individual variability, aging, and neurodegeneration, 44th annual International Neuropsychological Society meeting, Boston, MA, USA [Invited Lecture] 2017 Atypical Alzheimer’s disease: clinical and biomarker phenotypes, Alzheimer’s Association International Conference, London, UK [Invited Lecture] 2018 Behavioral, physiological, and imaging studies of arousal, valence, and salience processing, National Institute on Aging 2-day workshop on emotion, Bethesda, MD [Invited lecture and workshop session moderator] 2018 Primary Progressive Aphasia through the lens of ATN; International Conference on FTD Sydney, Australia [Invited Lecture] 2019 International Alzheimer’s Imaging Consortium, Los Angeles, CA [Invited introductory lecture; chair and moderator] 25

2019 Social cognitive dysfunction and Frontotemporal Dementia, World Congress of Neurology, Dubai [Invited keynote lecture] 2020 Structural brain abnormalities in young-onset Alzheimer’s disease; Alzheimer’s Association International Conference (virtual) [invited featured research symposium lecture]

Report of Clinical Activities and Innovations Current Licensure and Certification

2002 Diplomate of National Board of Medical Examiners 2003- Massachusetts Board of Registration in Medicine 2005- Diplomate of American Board of Psychiatry and Neurology 2012- Diplomate, Behavioral Neurology and Neuropsychiatry, United Council on Medical Specialties

Practice Activities

2003- Description: I evaluated and treat Neurology, Behavioral Patient Load: 5/week; 2006 patients in the Division of neurology Brigham and High level of complexity Cognitive and Behavioral Women's Hospital Neurology at BWH on a weekly basis. These patients were complex cases with dementia, head injury, or other disorders causing cognitive and behavioral symptoms.

2003- Description: I see patients on the Neurology, Massachusetts Patient Load: 3/day for 2016 MGH General Neurology General Hospital one month; Mid to high Consultation service for two weeks level complexity per year. Many of these cases require complex consultative evaluations for diagnostic and therapeutic purposes.

2006- Description: I evaluate and treat Neurology, Memory Patient Load: 5/week; 2008 patients in the Memory Disorders disorders Massachusetts High level of complexity Unit/Alzheimer's Disease Research General Hospital Center at MGH on a weekly basis. These patients are complex cases with dementia or other disorders causing cognitive and behavioral symptoms. Many are referred for high-level consultation.

2008- Description: I evaluate and treat Neurology, Memory Patient Load: 10- 26

patients in the FTD Unit/Memory disorders Massachusetts 16/week; High level of Disorders Unit at MGH for a full General Hospital complexity day clinic each week. These patients are complex cases with dementia or other disorders causing cognitive and behavioral symptoms. Many are referred for high-level consultation.

Report of Teaching and Education Innovations

02/11- FTD Unit Rounds: I launched FTD Unit Rounds, a 1-hour multidisciplinary case conference that is attended by 25-35 faculty and trainees, at which a complex case is presented by trainees and faculty and discussed. CME credit is available through MGH Neurology.

Report of Technological and Other Scientific Innovations

02/11- iCORTS: individualized Cortical Thickness Scores: A team in my lab created a quantitative analysis and reporting method for measurements of cortical thickness in an individual patient compared with a group of age-matched controls to identify structural brain abnormalities in diagnostic evaluation of patients with neurodegenerative dementias.

Report of Education of Patients and Service to the Community Activities Under my leadership, the MGH FTD Unit has hosted an annual caregiver education day since 2011 for patients and families with FTD and related disorders.

I make many community presentations for lay audiences sponsored by the Alzheimer’s Association, Association for FTD, and other lay organizations.

Recognition

2015 Certificate of appreciation, for serving as Alzheimer’s Association Chair of 2015 Spring Research Forum (400 lay attendees)

2016 Certificate of appreciation, for serving as Alzheimer’s Association Chair of 2016 Spring Research Forum (400 lay attendees) 27

2017 Certificate of appreciation, for serving as Alzheimer’s Association Chair of 2017 Spring Research Forum (400 lay attendees)

Report of Scholarship Publications Peer reviewed publications in print or other media Research investigations ** denotes primary mentee of Dr. Dickerson

1. deToledo-Morrell L, Goncharova I, Dickerson B, Wilson RS, Bennett DA. From healthy aging to Alzheimer_s disease: in vivo detection of entorhinal cortex atrophy. Ann NY Acad Sci. 2000;911:240-253.

2. deToledo-Morrell L, Dickerson BC, Sullivan MP, Spanovic C, Wilson R, Bennett DA. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease. Hippocampus. 2000;10:136-142.

3. Goncharova II*, Dickerson BC*, Stoub TR, deToledo-Morrell L (*authors contributed equally). MRI of human entorhinal cortex: a reliable protocol for volumetric measurement. Neurobiol Aging. 2001;22(5):737-45.

4. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, deToledo-Morrell L. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging. 2001;22(5):747-54.

5. Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA. Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol. 2004;56(1):27-35.

6. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005;65(3):404-11.

7. Desikan RS**, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Hyman BT, Albert MS, Killiany RJ. A computer-generated labeling system for subdividing the human cerebral cortex on MRI scans into gyral-based regions of interest. Neuroimage. 2006;31(3):968-980.

8. Wright CI, Williams D, Feczko E, Barrett LF, Dickerson BC, Schwartz CE, Wedig MM. Neuroanatomical correlates of extraversion and neuroticism. Cerebral Cortex. 2006;16(12):1809-1819.

9. Han X, Jovicich J, Salat D, van der Kouwe A, Quinn BT, Czanner S, Busa E, Pacheco J, Albert M, Killiany R, Maguire P, Rosas D, Makris N, Dale A, Dickerson BC*, Fischl B* (*authors 28

contributed equally). Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer. Neuroimage. 2006;32(1):180-194.

10. Atri A, Locascio JJ, Lin JM, Yap L, Dickerson BC, Grodstein F, Irizarry MC, Growdon JH, Greenberg SM. Prevalence and effects of lobar microhemorrhages in early-stage dementia. Neurodegenerative Diseases. 2006;2:305-312.

11. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. Journal of Neuroscience. 2006;26(40):10222-10231.

12. Wright CI, Feczko E, Dickerson BC, Williams D. Neuroanatomical correlates of personality in the elderly. Neuroimage. 2007;35(12):263-272. 13. Diamond EL, Miller S, Dickerson BC, Atri A, DePeau K, Fenstermacher E, Pihlajam_ki M, Celone K, Salisbury S, Gregas M, Rentz D, Sperling RA. Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease. Neurology. 2007;69(13):1331-41.

14. Wright CI, Dickerson BC, Feczko E, Negreira A, Williams D. A Functional Magnetic Resonance Imaging Study of Amygdala Responses to Human Faces in Aging and Mild Alzheimer's Disease. Biol Psychiatry. 2007 Dec 15;62(12):1388-95.

15. Feczko E**, Augustinack JC, Fischl B, Dickerson BC. An MRI-based method for measuring volume, thickness and surface area of entorhinal, perirhinal, and posterior parahippocampal cortex. Neurobiology of Aging. 2009;30(3):420-431.

16. Dickerson BC, Feczko E, Augustinack JC, Pacheco J, Morris JC, Fischl B, Buckner RL. Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area. Neurobiology of Aging. 2009;30 (3):432-440.

17. Dickerson BC, Miller SL, Greve DN, Dale AM, Albert MS, Schacter DL, Sperling RA. Prefrontal-hippocampal-fusiform activity during encoding predict intra-individual differences in free recall ability: An event-related functional-anatomic MRI study. Hippocampus. 2007;17(11):1060-1070.

18. Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of AD dementia across the spectrum of mild cognitive impairment. Archives of General Psychiatry. 2007;64(12):1443-1450.

19. Fennema-Notestine C, Gamst AC, Quinn BT, Pacheco J, Jernigan TL, Thal L, Buckner R, Killiany R, Blacker D, Dale AM, Fischl B, Dickerson BC*, Gollub RL*. [*authors contributed equally]. Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data. Neuroinformatics. 2007;5(4):235-245.

20. Dickerson BC, Fenstermacher E, Salat DH, Wolk DA, Maguire RP, Desikan R, Pacheco J, Quinn BT, van der Kouwe A, Greve DN, Blacker D, Albert MS, Killiany RJ, Fischl B. 29

Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. Neuroimage. 2008;39(1):10-18.

21. Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol. 2008;65(1):94-100.

22. Miller SL**, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamaki M, Sperling RA. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci U S A. 2008;105(6):2181-6.

23. Miller SL**, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J Neurol Neurosurg Psychiatry. 2008;79(6):630-5.

24. Miller SL**, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamaki M, Sperling RA. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2181-6. Epub 2008 Jan 31.

25. Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL. The cortical signature of Alzheimer_s disease: Regionally-specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex. 2009;19(3):497-510.

26. Miller MI, Priebe CE, Qiu A, Fischl B, Kolasny A, Brown T, Park Y, Ratnanather JT, Busa E, Jovicich J, Yu P, Dickerson BC, Buckner RL, and the Morphometry BIRN. Collaborative computational anatomy: An MRI morphometry study of the human brain via diffeomorphic metric mapping. Hum Brain Mapp. 2009;30(7):2132-2141.

27. Nandigam RNK, Viswanathan A, Delgado P, Skehan ME, Smith EE, Rosand J, Greenberg SM, Dickerson BC. MRI detection of cerebral microbleeds: Effect of susceptibility-weighted imaging, slice thickness, and field strength. AJNR Am J Neuroradiol, 2009;30(2):338-343.

28. Van Leemput K, Bakkour A, Benner T, Wiggins G, Wald LL, Augustinack J, Dickerson BC, Golland P, Fischl B. Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRI. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2008;11(Pt 1):235-43.

29. Wonderlick J, Ziegler D, Bakkour A, Locasio J, Corkin S, Dickerson BC. Reliability of MRI- derived cortical and subcortical morphometric measures: Effects of pulse sequence, voxel geometry, and parallel imaging. Neuroimage. 2009; Feb 15;44(4):1324-33.

30. Bakkour A**, Morris JC, Dickerson BC. The cortical signature of prodromal Alzheimer’s disease: Regionally-specific thinning predicts mild AD dementia. Neurology, 2009;72(12):1048-1055. 30

31. Polli FE, Wright CI, Milad MR, Dickerson BC, Vangel M, Barton JJ, Rauch SL, Manoach DS. Hemispheric differences in amygdala contributions to response monitoring. Neuroreport 2009;20(4):398-402.

32. Jovicich J, Czanner S, Han X, Salat D, van der Kouwe A, Quinn B, Pacheco J, Albert M, Killiany R, Blacker D, Maguire P, Rosas D, Makris N, Gollub R, Dale A, Dickerson B*, Fischl B*. [*Authors contributed equally] MRI-derived measurements of human subcortical, ventricular, and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors, and field strengths. Neuroimage, 2009; 46(1):177-192.

33. Van Leemput K, Bakkour A, Benner T, Wiggins G, Wald LL, Augustinack J, Dickerson BC*, Golland P*, Fischl B* [*Authors contributed equally]. Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus, 2009;19(6):507-509.

34. Pihlajamaki M, O’Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical fMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord 2010 Jan-Mar;24(1):28-36.

35. Weierich MR, Wright CI, Negreira A, Dickerson BC, Barrett LF. Novelty as a dimension in the affective brain. Neuroimage 2010 Feb 1;49(3):2871-8. Epub 2009 Sep 28.

36. King RD, George AT, Jeon T, Hynan LS, Youn TS, Kennedy DN, Dickerson B; the Alzheimer’s Disease Neuroimaging Initiative. Characterization of Atrophic Changes in the Cerebral Cortex Using Fractal Dimensional Analysis. Brain Imaging Behav. 2009 Jun;3(2):154- 166.

37. Wang L**, Negreira A, LaViolette P, Bakkour A, Sperling RA, Dickerson BC. Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus. 2010 Mar;20(3):345-51.

38. Wang L**, Laviolette P, O'Keefe K, Putcha D, Bakkour A, Van Dijk KR, Pihlajamäki M, Dickerson BC, Sperling RA. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals.Neuroimage. 2010 Jun;51(2):910-7. Epub 2010 Feb 24.

39. Wolk DA, Dunfee KL, Dickerson BC, Aizenstein HJ, Dekosky ST. A medial temporal lobe division of labor: Insights from memory in aging and early Alzheimer disease. Hippocampus. 2010 Mar 15. [Epub ahead of print]. 2011; 21(5):461-466.

40. Zaitchik D, Walker C, Miller S, Laviolette P, Feczko E, Dickerson BC. Mental state attribution and the temporoparietal junction: An fMRI study comparing belief, emotion, and perception. Neuropsychologia. 2010;48(9):2528-2536.

41. O'Brien JL, O'Keefe KM, LaViolette PS, DeLuca AN, Blacker D, Dickerson BC, Sperling RA. Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology. 2010 Jun 15;74(24):1969-76. 31

42. Wolk DA, Dickerson BC. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attention-executive network function in Alzheimer’s disease. Proceedings of the National Academy of Sciences USA. 2010 Jun 1;107(22):10256-61. Epub 2010 May 17.

43. Sapolsky D**, Bakkour A, Negreira A, Nalipinski P, Weintraub S, Mesulam M- M, Caplan D, Dickerson BC. Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia. Neurology 2010 Jul 27;75(4):358-66.

44. Bickart KC**, Wright CI, Dautoff RJ, Dickerson BC*, Barrett LF* [*equal contributions]. Amygdala volume and social network size in humans. Nat Neurosci 2011;14:163-164. 45. Moriguchi Y, Negreira A, Weierich M, Dautoff R, Dickerson BC, Wright CI, Barrett LF. Differential Hemodynamic Response in Affective Circuitry with Aging: An fMRI Study of Novelty, Valence, and Arousal. J Cogn Neurosci. 2011; 23(5):1027-1041.

46. Dickerson BC, Wolk DA. Dysexecutive vs. Amnesic phenotypes of very mild Alzheimer’s disease are associated with distinct clinical, genetic, and cortical thinning characteristics. Journal of Neurology, Neurosurgery, and Psychiatry 2011;82(1):45-51.

47. Weierich MR, Kensinger EA, Munnell AH, Sass SA, Dickerson BC, Wright CI, Barrett LF. Older and wiser? An affective science perspective on age-related challenges in financial decision making. Soc Cogn Affect Neurosci. 2011;6(2):195-206.

48. Smith EE, Salat DH, Jeng J, McCreary CR, Fischl B, Schmahmann JD, Dickerson BC, Viswanathan A, Albert MS, Blacker D, Greenberg SM. Correlations between MRI white matter lesion location and executive function and episodic memory. Neurology. 2011 Apr 26;76(17):1492-9.

49. Förster S, Grimmer T, Miederer I, Henriksen G, Yousefi BH, Graner P, Wester HJ, Förstl H, Kurz A, Dickerson BC, Bartenstein P, Drzezga A. Regional Expansion of Hypometabolism in Alzheimer's Disease Follows Amyloid Deposition with Temporal Delay. Biol Psychiatry. 2012; 71(9):792-797.

50. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 Sep;134(Pt 9):2456-77. Epub 2011 Aug 2.

51. Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, deToledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology 2011;76:1395-1402. 52. McGinnis SM**, Brickhouse M, Pascual B, Dickerson BC. Age-related changes in the 32

thickness of cortical zones in humans. Brain Topogr. 2011 Oct;24(3-4):279-91.

53. Poulin SP**, Dautoff R, Morris JC, Barrett LF, Dickerson BC; Alzheimer's Disease Neuroimaging Initiative. Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity. Psychiatry Res. 2011 Oct 30;194(1):7-13.

54. Putcha D**, Brickhouse M, O'Keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, Sperling R. Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults. J Neurosci. 2011 Nov 30;31(48):17680-8.

55. Dickerson BC, Wolk DA, ADNI Investigators. MRI cortical thickness biomarker predicts AD- like CSF and cognitive decline in normal adults. Neurology 2012 Jan 10;78(2):84-90.

56. Wolk DA, Dickerson BC, Alzheimer's Disease Neuroimaging I. Fractionating verbal episodic memory in Alzheimer's disease. Neuroimage 2011;54:1530-1539. 57. Entis JJ**, Doerga, P, Barrett LF, Dickerson BC. A reliable protocol for the manual segmentation of the human amygdala and its subregions using ultra-high resolution MRI. Neuroimage 2012 2012 Apr 2;60(2):1226-35.

58. Touroutoglou A**, Hollenbeck M, Dickerson BC*, Feldman Barrett L* [equal contributions]. Neuroimage. Dissociable large-scale networks anchored in the right anterior insula subserve affective experience and attention. 2012 May 1;60(4):1947-58.

59. Domoto-Reilly K**, Sapolsky D, Brickhouse M, Dickerson BC; for the Alzheimer's Disease Neuroimaging Initiative. Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophy. Neuroimage. 2012 Oct 15;63(1):348-55.

60. Das SR, Pluta J, Mancuso L, Kliot D, Orozco S, Dickerson BC, Yushkevich PA, Wolk DA. Increased functional connectivity within medial temporal lobe in mild cognitive impairment. Hippocampus 2013;23(1):1-6.

61. Bickart KC**, Hollenbeck M, Barrett LF, Dickerson BC. Intrinsic amygdala-cortical functional connectivity predicts social network size in humans. J Neuroscience 2012 Oct 17;32(42):14729- 41.

62. Quiroz YC**, Stern CE, Reiman E, Brickhouse M, Ruiz A, Sperling RA, Lopera F, Dickerson BC. Cortical atrophy in presymptomatic AD Presenilin 1 mutation carriers. Journal of Neurology, Neurosurgery, and Psychiatry 2013; 84(5):556-561.

63. Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JB, Kosik KS, Tariot PN, Lopera F. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol. 2012 Dec;11(12):1048-56.

64. Wolk DA, Mancuso L, Kliot D, Arnold SE, Dickerson BC. Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD. Neuropsychologia 2013;51(6):1094- 1102.

65. Bakkour A**, Morris JC, Wolk DA, Dickerson BC. The effects of aging and Alzheimer's disease on cerebral cortical anatomy: specificity and differential relationships with cognition. Neuroimage. 2013 Aug 1;76:332-44.

66. Lamarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Sha SJ, Perry DC, Miller ZA, Naasan G, Laforce R Jr, Hagen J, Takada LT, Tartaglia MC, Kang G, Galasko D, Salmon DP, Farias ST, Kaur B, Olichney JM, Quitania Park L, Mendez MF, Tsai PH, Teng E, Dickerson BC, Domoto-Reilly K, McGinnis S, Miller BL, Kramer JH. Interrater reliability of the new criteria for behavioral variant frontotemporal dementia. Neurology. 2013 May 21;80(21):1973- 7.

67. Makris N, Preti MG, Wassermann D, Rathi Y, Papadimitriou GM, Yergatian C, Dickerson BC, Shenton ME, Kubicki M. Human middle longitudinal fascicle: segregation and behavioral- clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography. Brain Imaging Behav. 2013; 7(3):335-352.

68. Heuer HW, Mirsky JB, Kong EL, Dickerson BC, Miller BL, Kramer JH, Boxer AL. Antisaccade task reflects cortical involvement in mild cognitive impairment. Neurology 2013;81(14):1235-1243.

69. Dickerson BC, Wolk DA; Alzheimer's Disease Neuroimaging Initiative. Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau. Front Aging Neurosci. 2013 Oct 11;5:55.

70. Pascual B**, Masdeu JC, Hollenbeck M, Makris N, Insausti R, Ding SL, Dickerson BC. Large- Scale Brain Networks of the Human Left Temporal Pole: A Functional Connectivity MRI Study. Cerebral Cortex. 2015; 25(3): 680-702.

71. Whitwell JL, Tosakulwong N, Weigand SD, Senjem ML, Lowe VJ, Gunter JL, Boeve BF, Knopman DS, Dickerson BC, Petersen RC, Jack CR Jr. Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects? Neuroimage Clin 2013;2:249-257.

72. Andreano JM**, Dickerson BC, Barrett LF. Sex Differences in the Persistence of the Amygdala Response to Negative Material. Soc Cogn Affect Neurosci. 2013; 9(9): 1388-1394. Bickart KC, Brickhouse M, Negreira A, Sapolsky D, Barrett LF, Dickerson BC. Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. J Neurol Neurosurg Psychiatry 2014;85:438-448.

73. Lindquist KA**, Gendron M, Barrett LF, & Dickerson BC. Emotion perception, but not affect perception, is impaired with semantic memory loss. Emotion. 2014; 14(2): 375-387.

74. Moriguchi Y, Touroutoglou A, Dickerson BC, Barrett LF. Sex differences in the neural 34

correlates of affective experience. Soc Cogn Affect Neurosci. 2014; 9(5):593-600.

75. Stoub TR, Detoledo-Morrell L, & Dickerson BC. Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults. Neurobiol Aging. 2014; 35(8): 1855-1861.

76. Gard T, Taquet M, Dixit R, Holzel BK, de Montjoye YA, Brach N, Salat DH, Dickerson BC, Gray JR, & Lazar SW. Fluid intelligence and brain functional organization in aging yoga and meditation practitioners. Front Aging Neurosci. 2014; 6: 76.

77. Touroutoglou A**, Bickart KC, Barrett LF, & Dickerson BC. Amygdala task-evoked activity and task-free connectivity independently contribute to feelings of arousal. Hum Brain Mapp. 2014; 35(10): 5316-5327.

78. Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, Mollenhauer B, Scherzer CR, Ivinson AJ, Finke C, Schols L, Muller Vom Hagen J, Trenkwalder C, Jahn H, Holtje M, Biswal BB, Harms L, Ruprecht K, Buchert R, Hoglinger GU, Oertel WH, Unger MM, Kortvelyessy P, Bittner D, Priller J, Spruth EJ, Paul F, Meisel A, Lynch DR, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stocker W, Dalmau J, & Pruss H. High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types. Ann Clin Transl Neurol. 2014; 1(10): 822-832.

79. Touroutoglou A**, Lindquist KA, Dickerson BC, & Barrett LF. Intrinsic connectivity in the human brain does not reveal networks for 'basic' emotions. Soc Cogn Affect Neurosci. 2015; 10(9): 1257-1265.

80. Gard T, Taquet M, Dixit R, Holzel BK, Dickerson BC, & Lazar SW. Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls. Front Hum Neurosci. 2015; 9: 137.

81. Barnes J, Dickerson BC, Frost C, Jiskoot LC, Wolk D, & van der Flier WM. Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset. Alzheimers Dement. 2015; 11(11): 1349-1357.

82. Touroutoglou A**, Andreano JM, Barrett LF, & Dickerson BC. Brain network connectivity- behavioral relationships exhibit trait-like properties: Evidence from hippocampal connectivity and memory. Hippocampus. 2015; 25(12): 1591-1598.

83. Quiroz YT**, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramirez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, & Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol 2015; 72(8), 912-919.

84. Marquie M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, & Gomez-Isla T. Validating novel tau 35

positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015; 78(5): 787-800.

85. Wisse LE, Butala N, Das SR, Davatzikos C, Dickerson BC, Vaishnavi SN, Yushkevich PA, Wolk DA, & Alzheimer's Disease Neuroimaging I. Suspected non-AD pathology in mild cognitive impairment. Neurobiol Aging. 2015; 36(12): 3152-3162.

86. Sarkis RA, Dickerson BC, Cole AJ, & Chemali ZN. Clinical and Neurophysiologic Characteristics of Unprovoked Seizures in Patients Diagnosed With Dementia. J Neuropsychiatry Clin Neurosci. 2016; 28(1): 56-61.

87. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, & Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016; 79(1): 110-119.

88. Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Dickerson BC, Marcantonio ER, Travison T, Inouye SK; Successful Aging after Elective Surgery Study Group.. The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures. J Am Geriatr Soc. 2015 Dec;63(12):2463-2471. doi: 10.1111/jgs.13793. PubMed PMID:26662213; PubMed Central PMCID: PMC4688907.

89. Touroutoglou A**, Bliss-Moreau E, Zhang J, Mantini D, Vanduffel W, Dickerson BC, & Barrett LF. A ventral salience network in the macaque brain. Neuroimage. 2016; 132: 190-197.

90. Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC, & Group SS. Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016; 139(Pt 4): 1282-1294.

91. Zhang Y, Walter R, Ng P, Luong PN, Dutt S, Heuer H, Rojas-Rodriguez JC, Tsai R, Litvan I, Dickerson BC, Tartaglia MC, Rabinovici G, Miller BL, Rosen HJ, Schuff N, Boxer AL. Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study. PLoS One. 2016 Jun 16;11(6):e0157218. doi: 10.1371/journal.pone.0157218. eCollection 2016. PubMed PMID: 27310132; PubMed Central PMCID: PMC4911077.

92. Cordella C**, Dickerson BC, Quimby M, Yunusova Y, Green JR. Slowed articulation rate is a sensitive diagnostic marker for identifying non-fluent primary progressive aphasia. . Aphasiology 2016;31:241-260.

93. Hshieh TT, Dai W, Cavallari M, Guttmann CR, Meier DS, Schmitt EM, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Gou YR, Travison TG, Fong TG, Ngo L, Inouye SK, Alsop DC; SAGES Study Group.. Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. J Cereb Blood Flow Metab. 2017 Apr;37(4):1386-1397. doi: 10.1177/0271678X16656014. Epub 2016 Jan 1. PubMed PMID: 36

27401806.

93. Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Mol Psychiatry. 2016 Oct;21(10):1483-4. doi: 10.1038/mp.2016.140. Epub 2016 Aug 16. PubMed PMID: 27528461; PubMed Central PMCID: PMC5030463.

93. Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration. Neuroimage Clin. 2015 Aug 18;12:332-40. doi: 10.1016/j.nicl.2015.08.002. eCollection 2016. PubMed PMID: 27547726; PubMed Central PMCID: PMC4983147.

94. Sun FW, Stepanovic MR, Andreano J, Barrett LF, Touroutoglou A, Dickerson BC. Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks Contributes to Youthful Memory in Superaging. J Neurosci. 2016 Sep 14;36(37):9659-68. doi: 10.1523/JNeurosci.1492-16.2016. PubMed PMID: 27629716; PubMed Central PMCID: PMC5039247.

95. Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol. 2016 Nov 1;73(11):1334-1341. doi: 10.1001/jamaneurol.2016.3338. PubMed PMID: 27654968; PubMed Central PMCID: PMC5287290.

96. Makris N, Zhu A, Papadimitriou GM, Mouradian P, Ng I, Scaccianoce E, Baselli G, Baglio F, Shenton ME, Rathi Y, Dickerson B, Yeterian E, Kubicki M. Mapping temporo-parietal and temporo-occipital cortico-cortical connections of the human middle longitudinal fascicle in subject-specific, probabilistic, and stereotaxic Talairach spaces. Brain Imaging Behav. 2016 Oct 6. PMID: 27714552; PubMed Central PMCID: PMC5382125.

97. Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR Jr, Miller BL, Rosen HJ, Boxer AL; AL-108-231 investigators.. Progression of brain atrophy in PSP and CBS over 6 months and 1 year. Neurology. 2016 Nov 8;87(19):2016-2025. Epub 2016 Oct 14. PubMed PMID: 27742814; PubMed Central PMCID: PMC5109951.

98. Evans WS, Quimby M, Dickey MW, Dickerson BC. Relearning and Retaining Personally-Relevant Words using Computer-Based Flashcard Software in Primary Progressive Aphasia. Front Hum Neurosci. 2016 Nov 16;10:561. eCollection 2016. PubMed PMID: 27899886; PubMed Central PMCID: PMC5110537.

99. Perez DL**, Young SS, King JN, Guarino AJ, Dworetzky BA, Flaherty A, Chemali Z, Caplan D, Dickerson BC. Preliminary Predictors of Initial Attendance, Symptom 37

Burden, and Motor Subtype in a US Functional Neurological Disorders Clinic Population. Cogn Behav Neurol. 2016 Dec;29(4):197-205. PubMed PMID: 27984257.

100. Xia C**, Touroutoglou A, Quigley KS, Feldman Barrett L, Dickerson BC. Salience Network Connectivity Modulates Skin Conductance Responses in Predicting Arousal Experience. J Cogn Neurosci. 2017 May;29(5):827-836. doi: 10.1162/jocn_a_01087. Epub 2016 Dec 19. PubMed PMID: 27991182.

101. Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan;81(1):117-128. doi: 10.1002/ana.24844. PubMed PMID: 27997036; PubMed Central PMCID: PMC5319193.

102. Collins JA**, Montal V, Hochberg D, Quimby M, Mandelli ML, Makris N, Seeley WW, Gorno-Tempini ML, Dickerson BC. Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia. Brain. 2017 Feb;140(Pt 2):457-471. doi: 10.1093/brain/aww313. Epub 2016 Dec 31. PubMed PMID: 28040670; PubMed Central PMCID: PMC5278308.

103. Atzil S, Touroutoglou A, Rudy T, Salcedo S, Feldman R, Hooker JM, Dickerson BC, Catana C, Barrett LF. Dopamine in the medial amygdala network mediates human bonding. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2361-2366. doi: 10.1073/pnas.1612233114. Epub 2017 Feb 13. PubMed PMID: 28193868; PubMed Central PMCID: PMC5338494.

104. Dickerson BC, Brickhouse M, McGinnis S, Wolk DA. Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome. Alzheimers Dement (Amst). 2016 Dec 22;6:122-135. doi: 10.1016/j.dadm.2016.12.007. eCollection 2017. PubMed PMID: 28239637; PubMed Central PMCID: PMC5318292.

105. Xia C**, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 Apr 1;74(4):427-436. doi: 10.1001/jamaneurol.2016.5755. PubMed PMID: 28241163.

106. Perez DL**, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC Jr, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 Jun;88(6):491-497. doi: 10.1136/jnnp-2016-314998. Epub 2017 Apr 17. PubMed PMID: 28416565.

107. Andreano JM**, Touroutoglou A, Dickerson BC, Feldman Barrett L. Resting Connectivity Between Salience Nodes Predicts Recognition Memory. Soc Cogn Affect 38

Neurosci. 2017 Apr 25. doi: 10.1093/scan/nsx026. PMID: 28449036.

Matin N, Young SS, Williams B, LaFrance WC Jr, King JN, Caplan D, Chemali Z, 108. Weilburg JB, Dickerson BC, Perez DL. Neuropsychiatric Associations With Gender, Illness Duration, Work Disability, and Motor Subtype in a U.S. Functional Neurological Disorders Clinic Population. J Neuropsychiatry Clin Neurosci. 2017 Apr 28:appineuropsych16110302. doi: 10.1176/appi.neuropsych.16110302. PMID: 28449634.

109. Darby RR**, Brickhouse M, Wolk DA, Dickerson BC, Alzheimer's Disease Neuroimaging I. Effects of cognitive reserve depend on executive and semantic demands of the task. J Neurol Neurosurg Psychiatry 2017;88:794-802.

110. Dickerson BC, Brickhouse M, McGinnis S, Wolk DA. Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome. Alzheimers Dement (Amst) 2017;6:122-135.

111. Dickerson BC, McGinnis SM, Xia C, Price BH, Atri A, Murray M, Mendez M, Wolk DA. Approach to atypical Alzheimer's disease and case studies of the major subtypes. CNS Spectr 2017:1-11.

112. Finger E, Zhang J, Dickerson B, Bureau Y, Masellis M, Alzheimer's Disease Neuroimaging I. Disinhibition in Alzheimer's Disease is Associated with Reduced Right Frontal Pole Cortical Thickness. J Alzheimers Dis 2017;60:1161-1170.

113. Kleckner IR, Zhang J, Touroutoglou A, Chanes L, Xia C, Simmons WK, Quigley KS, Dickerson BC*, Barrett LF* [*equal contributions]. Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans. Nat Hum Behav. 2017;1. pii: 0069. doi: 10.1038/s41562-017-0069.

114. Marquie M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Anton-Fernandez A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL,Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gomez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol 2017;81:117-128.

115. Matin N, Young SS, Williams B, LaFrance WC, King JN, Caplan D, Chemali Z, Weilburg JB, Dickerson BC, Perez DL. Neuropsychiatric Associations With Gender, Illness Duration, Work Disability, and Motor Subtype in a U.S. Functional Neurological Disorders Clinic Population. J Neuropsychiatry Clin Neurosci 2017: Fall;29(4):375-382.

116. Perez DL**, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry 2017;88:491-497.

117. Perez DL**, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, 39

Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry 2017; 88(12):1052-1059.

118. Poulin SP**, Bergeron D, Dickerson BC, Alzheimer's Disease Neuroimaging I. Risk Factors, Neuroanatomical Correlates, and Outcome of Neuropsychiatric Symptoms of Alzheimer's Disease. J Alzheimers Dis 2017; 60:483-493.

119. Racine AM**, Fong TG, Travison TG, Jones RN, Gou Y, Vasunilashorn SM, Marcantonio ER, Alsop DC, Inouye SK, Dickerson BC. Alzheimer's-related cortical atrophy is associated with postoperative delirium severity in persons without dementia. Neurobiol Aging 2017;59:55-63.

120. Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tasi LH. Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia. J Neurosci 2017;37:9917-9924.

121. She A**, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. Cell Chem Biol 2017;24:892-906 e895.

122. Xia C**, Touroutoglou A, Quigley KS, Feldman Barrett L, Dickerson BC. Salience Network Connectivity Modulates Skin Conductance Responses in Predicting Arousal Experience. J Cogn Neurosci 2017;29:827-836.

123. Xia C**, Makaretz SJ, Caso C, McGinnis SM, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol 2017; 74:427-436.

124. Schonhaut DR, McMillan CT, Spina S, Dickerson BC, Siderowf A, Devous MD, Tsai R, Winer J, Russell DS, Litvan I, Roberson ED, Seeley WW, Grinberg LT, Kramer JH, Miller BL, Pressman P, Nasrallah I, Baker SL, Gomperts SN, Johnson KA, Jagust WJ, Boxer AL, Rabinovici GD. 18 F-flortaucipir tau PET distinguishes established progressive supranuclear palsy from controls and Parkinson's disease: A multicenter study. Ann Neurol. 2017 Oct;82(4):622-634.

125. Finger E, Zhang J, Dickerson B, Bureau Y, Masellis M; Alzheimer’s Disease Neuroimaging Initiative. Disinhibition in Alzheimer's Disease is Associated with Reduced Right Frontal Pole Cortical Thickness. J Alzheimers Dis. 2017;60(3):1161-1170.

126. Makaretz SJ**, Quimby M, Collins J, Makris N, McGinnis SM, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. J Neurol Neurosurg Psychiatry. 2017 Oct 6. pii: jnnp-2017-316409. doi: 10.1136/jnnp- 2017-316409.

127. Perez DL**, Matin N, Williams B, Tanev K, Makris N, LaFrance WC Jr, Dickerson BC. 40

Cortical thickness alterations linked to somatoform and psychological dissociation in functional neurological disorders. Hum Brain Mapp. 2018 Jan;39(1):428-439.

128. Mustafa R, Brosch JR, Rabinovici GD, Dickerson BC, Carrillo MC, Glazier BS, Gao S, Tierney M, Fargo KN, Austrom MG, De Santi S, Clark DG, Apostolova LG. Patient and Caregiver Assessment of the Benefits From the Clinical Use of Amyloid PET Imaging. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):35-42.

129. Racine AM**, Fong TG, Gou Y, Travison TG, Tommet D, Erickson K, Jones RN, Dickerson BC, Metzger E, Marcantonio ER, Schmitt EM, Inouye SK. Clinical outcomes in older surgical patients with mild cognitive impairment. Alzheimers Dement. 2018 May;14(5):590-600.

130. Perez DL**, Williams B, Matin N, Mello J, Dickerson BC, LaFrance WC Jr, Keshavan MS. Anterior hippocampal grey matter predicts mental health outcome in functional neurological disorders: an exploratory pilot study. J Neurol Neurosurg Psychiatry. 2018 Jan 11. pii: jnnp- 2017-317305.

131. Smith EE, Muzikansky A, McCreary CR, Batool S, Viswanathan A, Dickerson BC, Johnson K, Greenberg SM, Blacker D. Impaired memory is more closely associated with brain beta-amyloid than leukoaraiosis in hypertensive patients with cognitive symptoms. PLoS One. 2018 Jan 30;13(1):e0191345.

132. Ide JS, Nedic S, Wong KF, Strey SL, Lawson EA, Dickerson BC, Wald LL, La Camera G, Mujica-Parodi LR. Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. Neuroimage. 2018 Jul 1;174:35-43.

133. Wojtowicz M, Gardner AJ, Stanwell P, Zafonte R, Dickerson BC, Iverson GL. Cortical thickness and subcortical brain volumes in professional rugby league players. Neuroimage Clin. 2018 Jan 10;18:377-381.

134. Wisse LEM, Das SR, Davatzikos C, Dickerson BC, Xie SX, Yushkevich PA, Wolk DA. Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration. Neuroimage Clin. 2018 Feb 8;18:407-412.

135. Chen KT**, Salcedo S, Chonde DB, Izquierdo-Garcia D, Levine MA, Price JC, Dickerson BC, Catana C. MR-assisted PET motion correction in simultaneous PET/MRI studies of dementia subjects. J Magn Reson Imaging. 2018 Mar 8. doi: 10.1002/jmri.26000.

136. Das SR, Xie L, Wisse LEM, Ittyerah R, Tustison NJ, Dickerson BC, Yushkevich PA, Wolk DA; Alzheimer's Disease Neuroimaging Initiative. Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake. Neurobiol Aging. 2018 Jun;66:49- 58.

137. Williams B, Jalilianhasanpour R, Matin N, Fricchione GL, Sepulcre J, Keshavan MS, LaFrance WC Jr, Dickerson BC, Perez DL. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. J Psychiatr Res. 2018 Apr 6;102:230-237.

138. Racine AM**, Brickhouse M, Wolk DA, Dickerson BC; Alzheimer's Disease Neuroimaging Initiative. The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment. Alzheimers Dement (Amst). 2018 Mar 17;10:301-310.

139. Putcha D**, McGinnis SM, Brickhouse M, Wong B, Sherman JC, Dickerson BC. Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy. Cortex. 2018 May 10;106:36-46.

140. Chen KT**, Salcedo S, Gong K, Chonde DB, Izquierdo-Garcia D, Drzezga AE, Rosen B, Qi J, Dickerson BC, Catana C. An Efficient Approach to Perform MR-assisted PET Data Optimization in Simultaneous PET/MR Neuroimaging Studies. J Nucl Med. 2018 Jun 22. pii: jnumed.117.207142. doi: 10.2967/jnumed.117.207142.

141. Collins JA**, Dickerson BC. Functional connectivity in category-selective brain networks after encoding predicts subsequent memory. Hippocampus. 2019;29(5):440-450. doi: 10.1002/hipo.23003. PMID:30009477

142. Illán-Gala I, Pegueroles J, Montal V, Vilaplana E, Carmona-Iragui M, Alcolea D, Dickerson BC, Sánchez-Valle R, de Leon MJ, Blesa R, Lleó A, Fortea J. Challenges associated with biomarker-based classification systems for Alzheimer's disease. Alzheimers Dement (Amst). 2018 Apr 21;10:346-357. doi: 10.1016/j.dadm.2018.03.004. eCollection 2018. PMID:30175226

143. Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. Ann Neurol. 2018 Nov;84(5):729-740.

144. Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, Miller B, Boxer AL, Rosen HJ. Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol. 2018 Sep 20;5(10):1250- 1263.

145. Ducharme S**, Pearl-Dowler L, Gossink F, McCarthy J, Lai J, Dickerson BC, Chertkow H, Rapin L, Vijverberg E, Krudop W, Dols A, Pijnenburg Y. The Frontotemporal Dementia versus Primary Psychiatric Disorder (FTD versus PPD) Checklist: A Bedside Clinical Tool to Identify Behavioral Variant FTD in Patients with Late-Onset Behavioral Changes. J Alzheimers Dis. 42

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146. Touroutoglou A**, Zhang J, Andreano JM, Dickerson BC, Barrett LF. Dissociable Effects of Aging on Salience Subnetwork Connectivity Mediate Age-Related Changes in Executive Function and Affect. Front Aging Neurosci. 2018 Dec 17;10:410.

147. Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller BL, Kramer JH, Boxer AL, Rosen HJ. Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials. Brain. 2019 Feb 1;142(2):443-459.

148. Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina JP, Dickerson BC, Keshavan MS, LaFrance WC Jr, Sepulcre J, Perez DL. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2019 Mar 8.

149. Cordella C**, Quimby M, Touroutoglou A, Brickhouse M, Dickerson BC, and Green JR. Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia. Neurology 2019; 92(17): e1992-e2004.

150. Putcha D**, Brickhouse M, Touroutoglou A, Collins JC, Quimby M, Wong B, Eldaief M, Schultz A, El Fakhri G, Johnson K, Dickerson BC, McGinnis SM. Visual cognition in non- amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy. Neuroimage Clin 2019; 23: 101889.

151. Putcha D**, Brickhouse M, Wolk DA, Dickerson BC, and ADNI consortium. Fractionating the Rey Auditory Verbal Learning Test: Distinct roles of large-scale cortical networks in prodromal Alzheimer's disease. Neuropsychologia 2019; 129: 83-92.

152. Silva MC**, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife 2019; 8.

153. Phillips ML, Stage EC Jr, Lane KA, Gao S, Risacher SL, Goukasian N, Saykin AJ, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; Alzheimer’s Disease Neuroimaging Initiative. Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer's Disease Subjects: Evidence for Disease Heterogeneity. Dement Geriatr Cogn Disord. 2019;48(3-4):131-142. doi:10.1159/000504341. Epub 2020 Jan 3. PubMed PMID: 31901905; PubMed Central PMCID: PMC7031037.

154. Hshieh TT, Vasunilashorn SM, D'Aquila ML, Arnold SE, Dickerson BC, Fong TG, Jones RN, Marcantonio ER, Schmitt EM, Xu G, Gou Y, Chen F, Kunze LJ, Vlassakov KV, Abdeen AR, Lange JK, Earp BE, Touroutoglou A, Carlyle BC, Kivisakk-Webb P, Travison TG, Dillon ST, Libermann TA, Inouye SK; RISE Study Group. The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile. Alzheimers Dement (Amst). 2019 Nov 6;11:752-762. doi: 10.1016/j.dadm.2019.09.004. eCollection 2019 Dec. PubMed PMID: 31737775; PubMed Central PMCID: PMC6849121. 43

155. Zhang J**, Abiose O, Katsumi Y, Touroutoglou A, Dickerson BC, Barrett LF. Intrinsic Functional Connectivity is Organized as Three Interdependent Gradients. Sci Rep. 2019 Nov 4;9(1):15976. doi: 10.1038/s41598-019-51793-7. PubMed PMID: 31685830; PubMed Central PMCID: PMC6828953.

156. Chen Q, Boeve BF, Schwarz CG, Reid R, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova RH, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford NR, Grossman M, Haley D, Heuer HW, Hsiung GR, Huey E, Irwin DJ, Jack CR, Jones DT, Jones L, Karydas AM, Knopman DS, Kornak J, Kramer J, Kremers W, Kukull WA, Lapid M, Lucente D, Lungu C, Mackenzie IRA, Manoochehri M, McGinnis S, Miller BL, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Sengdy P, Shaw L, Syrjanen J, Tatton N, Taylor J, Toga AW, Trojanowski J, Weintraub S, Wong B, Boxer AL, Rosen H, Wszolek Z, Kantarci K; LEFFTDS Consortium. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers. Neurobiol Aging. 2019 Nov;83:54-62. doi: 10.1016/j.neurobiolaging.2019.08.011. Epub 2019 Aug 15. PubMed PMID: 31585367; PubMed Central PMCID: PMC6858933.

157. Ospina JP, Larson AG, Jalilianhasanpour R, Williams B, Diez I, Dhand A, Dickerson BC, Perez DL. Individual differences in social network size linked to nucleus accumbens and hippocampal volumes in functional neurological disorder: A pilot study. J Affect Disord. 2019 Nov 1;258:50-54. doi:10.1016/j.jad.2019.07.061. Epub 2019 Jul 30. PubMed PMID: 31394458; PubMed Central PMCID: PMC6783807.

158. Schwarz AJ, Sundell KL, Charil A, Case MG, Jaeger RK, Scott D, Bracoud L, Oh J, Suhy J, Pontecorvo MJ, Dickerson BC, Siemers ER. Magnetic resonance imaging measures of brain atrophy from the EXPEDITION3 trial in mild Alzheimer's disease. Alzheimers Dement (N Y). 2019 Jul 30;5:328-337. doi: 10.1016/j.trci.2019.05.007. eCollection 2019. PubMed PMID: 31388559; PubMed Central PMCID: PMC6675941.

159. Zhang J**, Andreano JM, Dickerson BC, Touroutoglou A, Barrett LF. Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging. Cereb Cortex. 2020 Jan 10;30(1):72-84.

160. Staffaroni, A. M., L. Bajorek, K. B. Casaletto, Y. Cobigo, S. M. Goh, A. Wolf, H. W. Heuer, F. M. Elahi, P. A. Ljubenkov, R. Dever, J. Kornak, B. Appleby, J. Bove, Y. Bordelon, P. Brannelly, D. Brushaber, C. Caso, G. Coppola, C. Dheel, B. C. Dickerson, S. Dickinson, S. Dominguez, K. Domoto-Reilly, K. Faber, J. Ferrall, J. A. Fields, A. Fishman, J. Fong, T. Foroud, L. K. Forsberg, R. Gavrilova, D. Gearhart, B. Ghazanfari, N. Ghoshal, J. Goldman, J. Graff-Radford, N. Graff-Radford, I. Grant, M. Grossman, D. Haley, G. Y. Hsiung, E. D. Huey, D. J. Irwin, D. T. Jones, L. Jones, K. Kantarci, A. Karydas, D. I. Kaufer, D. R. Kerwin, D. S. Knopman, R. Kraft, W. K. Kremers, W. A. Kukull, I. Litvan, D. Lucente, C. Lungu, I. R. Mackenzie, M. Maldonado, M. Manoochehri, S. M. McGinnis, E. McKinley, M. F. Mendez, B. L. Miller, N. Multani, C. Onyike, J. Padmanabhan, A. Pantelyat, R. Pearlman, L. Petrucelli, M. Potter, R. Rademakers, E. M. Ramos, K. P. Rankin, K. Rascovsky, E. D. Roberson, E. Rogalski, P. Sengdy, L. M. Shaw, J. Syrjanen, M. C. Tartaglia, N. Tatton, J. Taylor, A. Toga, J. Q. Trojanowski, S. Weintraub, P. Wang, B. Wong, Z. Wszolek, A. L. Boxer, B. F. Boeve, J. H. 44

Kramer, H. J. Rosen and A. L. consortium. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimers Dement. 2020;16(1):11-21.

161. Staffaroni AM, Cobigo Y, Goh SM, Kornak J, Bajorek L, Chiang K, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dever R, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff- Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Heuer HW, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kramer JH, Kremers WK, Kukull WA, Litvan I, Ljubenkov PA, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Rosen HJ; ARTFL/LEFFTDS consortium. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimers Dement. 2020 Jan;16(1):37-48.

162. Boeve B, Bove J, Brannelly P, Brushaber D, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GR, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kraft R, Kramer J, Kremers W, Kukull W, Lapid M, Lucente D, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Syrjanen J, Tatton N, Taylor J, Toga A, Trojanowski J, Weintraub S, Wong B, Wszolek Z, Boxer A, Rosen H; LEFFTDS Consortium. The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology. Alzheimers Dement. 2020 Jan;16(1):22-36. doi: 10.1016/j.jalz.2019.06.4947. Epub 2020 Jan 6. PMID: 31636026; PMCID: PMC6949411.

163. Ye R, Touroutoglou A, Brickhouse M, Katz S, Growdon JH, Johnson KA, Dickerson BC, Gomperts SN. Topography of cortical thinning in the Lewy body diseases. Neuroimage Clin. 2020 Jan 31;26:102196. doi: 10.1016/j.nicl.2020.102196. [Epub ahead of print] PubMed PMID: 32059167; PubMed Central PMCID: PMC7016450.

164. Putcha D**, Dickerson BC, Brickhouse M, Johnson KA, Sperling RA, Papp KV. Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum. Neuropsychologia. 2020 Feb 10:107391. doi:10.1016/j.neuropsychologia.2020.107391. [Epub ahead of print] PubMed PMID:32057937.

165. Moore KM, Nicholas J, Grossman M, McMillan CT, Irwin DJ, Massimo L, Van Deerlin VM, Warren JD, Fox NC, Rossor MN, Mead S, Bocchetta M, Boeve BF, Knopman DS, Graff- Radford NR, Forsberg LK, Rademakers R, Wszolek ZK, van Swieten JC, Jiskoot LC, Meeter LH, Dopper EG, Papma JM, Snowden JS, Saxon J, Jones M, Pickering-Brown S, Le Ber I, Camuzat A, Brice A, Caroppo P, Ghidoni R, Pievani M, Benussi L, Binetti G, Dickerson BC, Lucente D, Krivensky S, Graff C, Öijerstedt L, Fallström M, Thonberg H, Ghoshal N, Morris 45

JC, Borroni B, Benussi A, Padovani A, Galimberti D, Scarpini E, Fumagalli GG, Mackenzie IR, Hsiung GR, Sengdy P, Boxer AL, Rosen H, Taylor JB, Synofzik M, Wilke C, Sulzer P, Hodges JR, Halliday G, Kwok J, Sanchez-Valle R, Lladó A, Borrego-Ecija S, Santana I, Almeida MR, Tábuas-Pereira M, Moreno F, Barandiaran M, Indakoetxea B, Levin J, Danek A, Rowe JB, Cope TE, Otto M, Anderl-Straub S, de Mendonça A, Maruta C, Masellis M, Black SE, Couratier P, Lautrette G, Huey ED, Sorbi S, Nacmias B, Laforce R Jr, Tremblay ML, Vandenberghe R, Damme PV, Rogalski EJ, Weintraub S, Gerhard A, Onyike CU, Ducharme S, Papageorgiou SG, Ng ASL, Brodtmann A, Finger E, Guerreiro R, Bras J, Rohrer JD; FTD Prevention Initiative. Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study. Lancet Neurol. 2020 Feb;19(2):145-156. doi:10.1016/S1474-4422(19)30394-1. Epub 2019 Dec 3. Erratum in: Lancet Neurol. 2020 Feb;19(2):e2. PubMed PMID: 31810826; PubMed Central PMCID: PMC7007771.

166. Luo C, Makaretz S, Stepanovic M, Papadimitriou G, Quimby M, Palanivelu S, Dickerson BC, Makris N. Middle longitudinal fascicle is associated with semantic processing deficits in primary progressive aphasia. Neuroimage Clin. 2020;25:102115. doi: 10.1016/j.nicl.2019.102115. Epub 2019 Dec 4. PubMed PMID:31865024; PubMed Central PMCID: PMC6931233.

167. Olney NT, Ong E, Goh SM, Bajorek L, Dever R, Staffaroni AM, Cobigo Y, Bock M, Chiang K, Ljubenkov P, Kornak J, Heuer HW, Wang P, Rascovsky K, Wolf A, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dickerson BC, Dickinson S, Domoto-Reilly K, Faber K, Ferrall J, Fields J, Fishman A, Fong J, Foroud T, Forsberg LK, Gearhart DJ, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford NR, Grant I, Grossman M, Haley D, Hsiung G, Huey ED, Irwin DJ, Jones DT, Kantarci K, Karydas AM, Kaufer D, Kerwin D, Knopman DS, Kramer JH, Kraft R, Kremers W, Kukull W, Lapid MI, Litvan I, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley EC, Mendez MF, Miller BL, Onyike C, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wong B, Wszolek Z, Boxer AL, Boeve BF, Rosen HJ; ARTFL and LEFFTDS consortia. Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration. Alzheimers Dement. 2020 Jan;16(1):49-59. doi:10.1016/j.jalz.2019.08.196. Epub 2020 Jan 6. PubMed PMID: 31784375; PubMed Central PMCID: PMC6988137.

168. Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Deverasetty S, Qin Y, van Blitterswijk M, Jackson J, Appleby B, Bordelon Y, Brannelly P, Brushaber DE, Dickerson B, Dickinson S, Domoto-Reilly K, Faber K, Fields J, Fong J, Foroud T, Forsberg LK, Gavrilova R, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Heuer HW, Hsiung GR, Huey E, Irwin D, Kantarci K, Karydas A, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer JH, Kremers W, Kukull W, Litvan I, Ljubenkov P, Lungu C, Mackenzie I, Mendez MF, Miller BL, Onyike C, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Shaw L, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wong B, Wszolek Z, Rademakers R, Boeve BF, Rosen HJ, Boxer AL; ARTFL/LEFFTDS consortium, Coppola G. Genetic screening of a large series of North American sporadic and familial 46

frontotemporal dementia cases. Alzheimers Dement. 2020 Jan;16(1):118-130. doi: 10.1002/alz.12011. PMID: 31914217; PMCID: PMC7199807.

169. Miyagawa T, Brushaber D, Syrjanen J, Kremers W, Fields J, Forsberg LK, Heuer HW, Knopman D, Kornak J, Boxer A, Rosen HJ, Boeve BF, Appleby B, Bordelon Y, Bove J, Brannelly P, Caso C, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrell J, Fishman A, Fong J, Foroud T, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman JS, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung R, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Kaufer D, Kerwin D, Kraft R, Kramer J, Kukull W, Litvan I, Lucente D, Lungu C, Mackenzie I, Maldonado M, Manoochehri M, McGinnis S, McKinley E, Mendez MF, Miller B, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw L, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Wang P, Weintraub S, Wong B, Wszolek Z. Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Alzheimers Dement. 2020 Jan;16(1):106-117. doi: 10.1002/alz.12033. PMID: 31914218; PMCID: PMC7202045.

170. Toller G, Ranasinghe K, Cobigo Y, Staffaroni A, Appleby B, Brushaber D, Coppola G, Dickerson B, Domoto-Reilly K, Fields J, Fong J, Forsberg L, Ghoshal N, Graff-Radford N, Grossman M, Heuer H, Hsiung GY, Huey E, Irwin D, Kantarci K, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer J, Litvan I, Mackenzie I, Mendez M, Miller B, Rademakers R, Ramos E, Rascovsky K, Roberson E, Syrjanen J, Tartaglia C, Weintraub S, Boeve B, Boxer A, Rosen H, Rankin K; ARTFL/LEFFTDS Consortium. Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials. Neurology. 2020 Jun 2;94(22):e2384-e2395. doi: 10.1212/WNL.0000000000009451. Epub 2020 May 5. PMID: 32371446; PMCID: PMC7357291.

171. Bejanin A, Tammewar G, Marx G, Cobigo Y, Iaccarino L, Kornak J, Staffaroni AM, Dickerson BC, Boeve BF, Knopman DS, Gorno-Tempini M, Miller BL, Jagust WJ, Boxer AL, Rosen HJ, Rabinovici GD. Longitudinal structural and metabolic changes in frontotemporal dementia. Neurology. 2020 Jul 14;95(2):e140-e154. doi: 10.1212/WNL.0000000000009760. Epub 2020 Jun 26. PMID: 32591470; PMCID: PMC7455324.

172. Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020 Jun 26;11(1):3258. doi: 10.1038/s41467-020-16984-1. PMID: 32591533; PMCID: PMC7320012.

173. Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GY, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, 47

Kornak J, Kramer J, Kukull W, Lucente D, Lungu C, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Tatton N, Taylor J, Toga A, Trojanowski J, Weintraub S, Wong B, Wszolek Z, Boeve BF, Boxer A, Rosen H; LEFFTDS Consortium. Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort. Alzheimers Dement. 2020 Aug;16(8):1115-1124. doi: 10.1002/alz.12095. Epub 2020 Jul 13. PMID: 32656921; PMCID: PMC7534513.

174. Racine AM, Touroutoglou A, Abrantes T, Wong B, Fong TG, Cavallari M, Travison TG, Gou Y, Marcantonio ER, Alsop DC, Jones RN, Inouye SK, Dickerson BC; SAGES study group. Older Patients with Alzheimer's Disease-Related Cortical Atrophy Who Develop Post-Operative Delirium May Be at Increased Risk of Long- Term Cognitive Decline After Surgery. J Alzheimers Dis. 2020;75(1):187-199. doi: 10.3233/JAD-190380. PMID: 32250290; PMCID: PMC7304614.

175. Heuer HW, Wang P, Rascovsky K, Wolf A, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber DE, Caso C, Coppola G, Dickerson B, Dickinson S, Domoto- Reilly K, Faber K, Ferrall J, Fields J, Fishman A, Fong J, Foroud T, Forsberg LK, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff- Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey E, Irwin D, Jones D, Kantarci K, Karydas A, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer JH, Kraft R, Kremers WK, Kukull W, Litvan I, Ljubenkov P, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis S, McKinley E, Mendez MF, Miller BL, Onyike C, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Roberson ED, Rogalski E, Sengdy P, Shaw L, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski J, Weintraub S, Wong B, Wszolek Z, Boeve BF, Rosen HJ, Boxer AL; ARTFL and LEFFTDS consortia. Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort. Alzheimers Dement. 2020 Jan;16(1):60-70. doi: 10.1002/alz.12046. PMID: 31914226; PMCID: PMC7192555.

176. Casaletto KB, Staffaroni AM, Wolf A, Appleby B, Brushaber D, Coppola G, Dickerson B, Domoto-Reilly K, Elahi FM, Fields J, Fong JC, Forsberg L, Ghoshal N, Graff-Radford N, Grossman M, Heuer HW, Hsiung GY, Huey ED, Irwin D, Kantarci K, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer JH, Litvan I, Mackenzie IR, Mendez M, Miller B, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Syrjanen JA, Tartaglia MC, Weintraub S, Boeve B, Boxer AL, Rosen H, Yaffe K; ARTFL/LEFFTDS Study. Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration. Alzheimers Dement. 2020 Jan;16(1):91-105. doi: 10.1002/alz.12001. PMID: 31914227; PMCID: PMC6953618.

177. Katsumi Y, Racine AM, Torrado-Carvajal A, Loggia ML, Hooker JM, Greve DN, Hightower BG, Catana C, Cavallari M, Arnold SE, Fong TG, Vasunilashorn SM, Marcantonio ER, Schmitt EM, Xu G, Libermann TA, Barrett LF, Inouye SK, Dickerson BC, Touroutoglou A, Collins JA; RISE Study Group. The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding 48

and exploration of its link to post-operative delirium. Neuroimage Clin. 2020;27:102346. doi: 10.1016/j.nicl.2020.102346. Epub 2020 Jul 14. PMID: 32712451; PMCID: PMC7390821.

178. Racine AM, Tommet D, D'Aquila ML, Fong TG, Gou Y, Tabloski PA, Metzger ED, Hshieh TT, Schmitt EM, Vasunilashorn SM, Kunze L, Vlassakov K, Abdeen A, Lange J, Earp B, Dickerson BC, Marcantonio ER, Steingrimsson J, Travison TG, Inouye SK, Jones RN; , the RISE Study Group. Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients. J Gen Intern Med. 2020 Oct 19. doi: 10.1007/s11606-020-06238-7. Epub ahead of print. PMID: 33078300.

179. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 Nov;131(5):1529-1539. doi: 10.1213/ANE.0000000000004781. PMID: 33079876; PMCID: PMC7553194.

180. Bannon S, Reichman M, Popok P, Wagner J, Gates M, Uppal S, LeFeber L, Wong B, Dickerson BC, Vranceanu AM. In It Together: A Qualitative Meta-Synthesis of Common and Unique Psychosocial Stressors and Adaptive Coping Strategies of Persons With Young-Onset Dementia and Their Caregivers. Gerontologist. 2020 Oct 30:gnaa169. doi: 10.1093/geront/gnaa169. Epub ahead of print. PMID: 33125490.

181. Chu SA, Flagan TM, Staffaroni AM, Jiskoot LC, Deng J, Spina S, Zhang L, Sturm VE, Yokoyama JS, Seeley WW, Papma JM, Geschwind DH, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Forsberg LK, Brushaber DE, Grossman M, Coppola G, Dickerson BC, Bordelon YM, Faber K, Feldman HH, Fields JA, Fong JC, Foroud T, Gavrilova RH, Ghoshal N, Graff-Radford NR, Hsiung GR, Huey ED, Irwin DJ, Kantarci K, Kaufer DI, Karydas AM, Knopman DS, Kornak J, Kramer JH, Kukull WA, Lapid MI, Litvan I, Mackenzie IRA, Mendez MF, Miller BL, Onyike CU, Pantelyat AY, Rademakers R, Marisa Ramos E, Roberson ED, Carmela Tartaglia M, Tatton NA, Toga AW, Vetor A, Weintraub S, Wong B, Wszolek ZK; ARTFL/LEFFTDS Consortium, Van Swieten JC, Lee SE. Brain volumetric deficits in MAPT mutation carriers: a multisite study. Ann Clin Transl Neurol. 2020 Nov 28. doi: 10.1002/acn3.51249. Epub ahead of print. PMID: 33247623.

182. Islam MR, Luo R, Valaris S, Haley EB, Takase H, Chen YI, Dickerson BC, Schon K, Arai K, Nguyen CT, Wrann CD. Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice. Brain Plast. 2020 Oct 1;5(2):147-159. doi: 10.3233/BPL-190090. PMID: 33282678; PMCID: PMC7685674.

Other peer-reviewed publications

1. Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying 49

therapies in Alzheimer_s disease. NeuroRx. 2005;2:348-360. [peer-reviewed review] 2. Dickerson BC. Functional MRI of cholinergic modulation in mild cognitive impairment. Curr Opin Psychiatry. 2006 May;19(3):299-306. [peer-reviewed review] 3. Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: Insights from functional MRI studies. Neuropsychologia. 2008;46(6):1624-1635. [peer-reviewed invited review] 4. Sapolsky D**, Domoto-Reilly K, Negreira A, Brickhouse M, McGinnis S, Dickerson BC. Monitoring progression of primary progressive aphasia: Current approaches and future directions. Neurodegenerative Disease Management 2011 1(1): 43-55. [peer-reviewed review] 5. Dickerson BC. Diagnostic tests for Alzheimer disease: Judicious use can be helpful in clinical practice. Neurol Clin Pract. 2012 Jun;2(2):154-157. [peer-reviewed review] 6. Modirrousta M**, Price BH, Dickerson BC. Neuropsychiatric symptoms in primary progressive aphasia: phenomenology, pathophysiology, and approach to assessment and treatment. Neurodegener Dis Manag. 2013 Apr 1;3(2):133-146. [peer reviewed review] 7. Bickart KC**, Dickerson BC, & Barrett LF. The amygdala as a hub in brain networks that support social life. Neuropsychologia. 2014; 63: 235-248. [peer reviewed review] 8. Sapolsky D**, Domoto-Reilly K, & Dickerson BC. Use of the Progressive Aphasia Severity Scale (PASS) in monitoring speech and language status in PPA. Aphasiology. 2014; 28(8-9): 993-1003. [peer reviewed review] 9. Perez DL**, Dworetzky BA, Dickerson BC, Leung L, Cohn R, Baslet G, & Silbersweig DA. An integrative neurocircuit perspective on psychogenic nonepileptic seizures and functional movement disorders: neural functional unawareness. Clin EEG Neurosci. 2015; 46(1): 4-15. [peer reviewed review] 10. Dickerson BC. New tools for the evaluation of patients with neurodegenerative diseases. Neurodegener Dis Manag. 2014; 4(6): 403-405. [peer reviewed review] 11. Ghetti B, Oblak AL, Boeve BF, Johnson KA, Dickerson BC, & Goedert M. Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging. Neuropathol Appl Neurobiol. 2015; 41(1): 24-46. [peer reviewed review] 12. Ducharme S** & Dickerson BC. The neuropsychiatric examination of the young-onset dementias. Psychiatr Clin North Am. 2015; 38(2): 249-264. [peer reviewed review] 13. Dickerson BC. Dysfunction of social cognition and behavior. Continuum (Minneap Minn). 2015; 21(3 Behavioral Neurology and Neuropsychiatry): 660-677. [peer reviewed review] 14. Ducharme S**, Price BH, Larvie M, Dougherty DD, & Dickerson BC. Clinical Approach to the Differential Diagnosis Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders. Am J Psychiatry. 2015; 172(9): 827-837. [peer reviewed review] 15. Crutch SJ, Schott JM, Rabinovici GD, Boeve BF, Cappa SF, Dickerson BC, Dubois B, Graff- Radford NR, Krolak-Salmon P, Lehmann M, Mendez MF, Pijnenburg Y, Ryan NS, Scheltens P, Shakespeare T, Tang-Wai DF, van der Flier WM, Bain L, Carrillo MC, Fox NC. Shining a light on posterior cortical atrophy. Alzheimers Dement. 2012 Dec 28. [peer reviewed review] 16. Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM, Dickerson BC, Vandenberghe R, Ahmed S, Bak TH, Boeve BF, Butler C, Cappa SF, Ceccaldi M, de Souza LC, Dubois B, Felician O, Galasko D, Graff-Radford J, Graff-Radford NR, Hof PR, Krolak-Salmon P, Lehmann M, Magnin E, Mendez MF, Nestor PJ, Onyike CU, Pelak VS, Pijnenburg Y, Primativo S, Rossor MN, Ryan NS, Scheltens P, Shakespeare TJ, Suárez González A, Tang-Wai DF, Yong KX, Carrillo M, Fox NC;

Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest Area.. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017 Mar 2. pii: S1552-5260(17)30040-7. doi: 10.1016/j.jalz.2017.01.014. [Epub ahead of print] PubMed PMID: 28259709. [peer reviewed diagnostic guidelines] 17. Ducharme S**, Bajestan S, Dickerson BC, Voon V. Psychiatric Presentations of C9orf72 Mutation: What Are the Diagnostic Implications for Clinicians? J Neuropsychiatry Clin Neurosci 2017;29:195-205. [peer reviewed review] 18. Ducharme S**, Price BH, Dickerson BC. Apathy: a neurocircuitry model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):389-396. 19. Darby RR**, Dickerson BC. Dementia, Decision Making, and Capacity. Harv Rev Psychiatry. 2017 Nov/Dec;25(6):270-278. [peer reviewed review] 20. Andreano JM**, Touroutoglou A, Dickerson B, Barrett LF. Hormonal Cycles, Brain Network Connectivity, and Windows of Vulnerability to Affective Disorder. Trends Neurosci. 2018 Oct;41(10):660-676. [peer reviewed review] 21. Desmarais P, Rohrer JD, Nguyen QD, Herrmann N, Stuss DT, Lang AE, Boxer AL, Dickerson BC, Rosen H, van Swieten JC, Meeter LH, Borroni B, Tartaglia MC, Feldman HH, Black SE, Masellis M. Therapeutic trial design for frontotemporal dementia and related disorders. J Neurol Neurosurg Psychiatry. 2018 Oct 25. [peer reviewed review] 22. Wong B**, Lucente DE, MacLean J, Padmanabhan J, Quimby M, Brandt KD, Putcha D, Sherman J, Frosch MP, McGinnis S, Dickerson BC. Diagnostic evaluation and monitoring of patients with posterior cortical atrophy. Neurodegener Dis Manag. 2019 Aug;9(4):217-239. doi: 10.2217/nmt-2018-0052. Epub 2019 Aug 8. PubMed PMID: 31392920; PubMed Central PMCID: PMC6949516. [peer reviewed review] 23. Boxer AL, Gold M, Feldman H, Boeve BF, Dickinson SL, Fillit H, Ho C, Paul R, Pearlman R, Sutherland M, Verma A, Arneric SP, Alexander BM, Dickerson BC, Dorsey ER, Grossman M, Huey ED, Irizarry MC, Marks WJ, Masellis M, McFarland F, Niehoff D, Onyike CU, Paganoni S, Panzara MA, Rockwood K, Rohrer JD, Rosen H, Schuck RN, Soares HD, Tatton N. New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Alzheimers Dement. 2020 Jan;16(1):131-143. doi: 10.1016/j.jalz.2019.06.4956. Epub 2020 Jan 6. PubMed PMID: 31668596; PubMed Central PMCID: PMC6949386. [peer reviewed review] 24. Touroutoglou A**, Dickerson BC. Cingulate-centered large-scale networks: Normal functions, aging, and neurodegenerative disease. Handb Clin Neurol. 2019;166:113-127. doi: 10.1016/B978-0-444-64196-0.00008-X. PubMed PMID: 31731908. [peer reviewed review] 25. Touroutoglou A**, Andreano J, Dickerson BC, Barrett LF. The tenacious brain: How the anterior mid-cingulate contributes to achieving goals. Cortex. 2020 Feb;123:12-29. doi: 10.1016/j.cortex.2019.09.011. Epub 2019 Oct 9. Review. PubMed PMID: 31733343. [peer

reviewed review]

Boxer AL, Gold M, Feldman H, Boeve BF, Dickinson SL, Fillit H, Ho C, Paul R, 26. Pearlman R, Sutherland M, Verma A, Arneric SP, Alexander BM, Dickerson BC,

Dorsey ER, Grossman M, Huey ED, Irizarry MC, Marks WJ, Masellis M, McFarland F,

Niehoff D, Onyike CU, Paganoni S, Panzara MA, Rockwood K, Rohrer JD, Rosen H, Schuck RN, Soares HD, Tatton N. New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Alzheimers Dement. 2020 Jan;16(1):131-143. doi: 10.1016/j.jalz.2019.06.4956. Epub 2020 Jan 6. PMID: 31668596; PMCID: PMC6949386.

Scholarship without named authorship 1. Brittain C, McCarthy A, Irizarry MC, McDermott D, Biglan K, Höglinger GU, Lorenzl S, Del Ser T, Boxer AL; AL-108-231 Study Group; PROPSPERA investigators; 4RNTI-1 authors (includes Dickerson BC); Tau Restoration on PSP (TAUROS) Investigators. Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations. Parkinsonism Relat Disord. 2018 Sep 4. pii: S1353-8020(18)30384-5. 2. Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL; Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators (includes Dickerson BC). Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 Mar 2. doi: 10.1038/s41591-020-0762-2. [Epub ahead of print] PubMed PMID: 32123386. 3. Lang AE, Stebbins GT, Wang P, Jabbari E, Lamb R, Morris H, Boxer AL; 4RTNI; PROSPECT-M-UK investigators (includes Dickerson BC). The Cortical Basal ganglia Functional Scale (CBFS):Development and preliminary validation. Parkinsonism Relat Disord. 2020 Aug 25;79:121-126. doi: 10.1016/j.parkreldis.2020.08.021. Epub ahead of print. PMID: 32947108.

Non-peer reviewed scientific or medical publications/materials in print or other media

Reviews, chapters, monographs, and editorials

1. Dickerson BC. Functional MRI in the early detection of dementias. Rev Neurol (Paris). 2006;162(10):941-944. 2. Dickerson BC. The entorhinal cortex as an anatomical mediator of genetic vulnerability to Alzheimer's disease. [invited commentary]. Lancet Neurology. 2007;6(6):471-473. 3. Dickerson BC. Advances in functional MRI: Technology and clinical applications (invited review). Neurotherapeutics. 2007;4(3):360-370. 4. Dickerson BC, Sperling RA. Functional MRI in mild cognitive impairment and Alzheimer's disease. In: Functional neuroimaging of dementia (Rombouts SARB, ed). 2007. Book chapter. 5. Dickerson BC. Acute confusional states. In: In: Greene HL, Mushlin SB, eds. Decision Making in Medicine: An algorithmic approach. St. Louis (MO): Mosby;2008. Book chapter. 6. Dickerson BC. Chronic behavior change. In: In: Greene HL, Mushlin SB, eds. Decision Making in Medicine: An algorithmic approach. St. Louis (MO): Mosby;2008. Book chapter. 7. Dickerson BC. Memory loss. In: In: Greene HL, Mushlin SB, eds. Decision Making in Medicine: An algorithmic approach. St. Louis (MO): Mosby;2008. Book chapter. 8. Dickerson BC. The medial temporal lobe: Anatomy and clinical relevance. In: MGH Comprehensive Textbook of Psychiatry (Rausch S et al., eds). Philadelphia, PA: Elsevier;2008. Book chapter. 9. Mueller SG, Dickerson BC. Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer disease. Neurology. 2008;70(19 Pt 2):1728-9. [invited editorial]

10. Dickerson BC. Functional MRI in neurodegenerative diseases: From scientific insights to clinical applications. In: Functional MRI techniques, Filippi M (ed). Totowa (NJ): Humana Press;2008. Book chapter 11. Dickerson BC. Pre-dementia diagnosis of Alzheimer’s disease: Translating clinicobiologic research into practice. Current Psychiatry Reviews. 2008. [invited review] 12. Dickerson BC. Imaging biomarkers for drug development in Alzheimer's disease. In: Imaging in CNS drug development: Implications for disease and therapy (Borsook D, Hargreaves R, Bullmore E, Becerra L, eds). New York, NY: Springer;2008. Book chapter 13. Dickerson BC. Invited guest editor for this volume. Special issue of journal Hippocampus on high resolution computational anatomy of the hippocampus. 2009; 19(6). 14. Dickerson BC. New frontiers in computational analysis of human hippocampal anatomy. Hippocampus 2009 Jun;19(6):507-9. Review. 15. Dickerson BC, Eichenbaum H. The episodic memory system: neurocircuitry and disorders. Neuropsychopharmacology. 2010 Jan;35(1):86-104. Epub . Review. 16. Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol. 2009;21(1):63-75. Review. 17. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010 Mar;12(1):27-43. Review. 18. Dickerson BC. Advances in quantitative magnetic resonance imaging-based biomarkers for Alzheimer disease. Alzheimers Res Ther. 2010 Jul 6;2(4):21. Review. 19. Dickerson BC. Primary progressive aphasia: New insights paving the way toward clinical research tools. Neurology. 2010 Aug 17;75(7):582-3. Review. 20. Dickerson BC. Molecular neuroimaging of neurodegenerative dementias. In: Alzheimer's disease and related dementias (Budson AE, Kowall N, eds). Boston, MA: Blackwell Scientific;2011. Book chapter. 21. Dickerson BC. Quantitating severity and progression in Primary Progressive Aphasia. J Mol Neurosci. 2011 Nov;45(3):618-28. Epub 2011 May 15. Review. 22. Dickerson BC, Augustinack JC. Imaging the hippocampus. In: Clinical neurobiology of the hippocampus. (Bartsch T, ed.). Oxford University Press. 2011. Book chapter 23. Johnson KA, Dickerson BC. A tale of two tracers: the age of wisdom for dementia diagnosis? Neurology. 2011 Dec 6;77(23):2008-9. Epub 2011 Nov 30. [invited editorial] 24. Xia C, Dickerson BC. Tau PET: the next frontier in molecular imaging of dementia. Int Psychogeriatr. 2016 Sep;28(9):1403-6. doi: 10.1017/S1041610216000880. Epub 2016 Jun 23. PubMed PMID: 27334648. 25. Roiser JP, Linden DE, Gorno-Tempinin ML, Moran RJ, Dickerson BC, Grafton ST. Minimum statistical standards for submissions to Neuroimage: Clinical. Neuroimage Clin. 2016 Nov 2;12:1045-1047. eCollection 2016. PubMed PMID: 27995071; PubMed Central PMCID: PMC5153601.

Case reports 1. Dickerson BC, Holtzman D, Grant PE, Tian D. Case 36-2005 -- A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status. N Engl J Med. 2005;353(21):2271-2280.

2. Perez DL, Dickerson BC, McGinnis SM, Sapolsky D, Johnson K, Searl M, Daffner KR. You Don't Say: Dynamic Aphasia, Another Variant of Primary Progressive Aphasia? J Alzheimers Dis. 2013;34(1):139-144. 3. Miller BL, Dickerson BC, Lucente DE, Larvie M, & Frosch MP. Case records of the Massachusetts General Hospital. Case 9-2015. A 31-year-old man with personality changes and progressive neurologic decline. N Engl J Med. 2015; 372(12): 1151-1162. 4. Ducharme S, Dickerson BC, Larvie M, & Price BH. Differentiating frontotemporal dementia from catatonia: a complex neuropsychiatric challenge. J Neuropsychiatry Clin Neurosci. 2015; 27(2): e174-176. 5. Ducharme S, Dickerson BC, & Price BH. Improvement in athletic performance as an early symptom of behavioral variant frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2015; 27(2): e163-164. 6. Mitchell SB, Lucente D, Larvie M, Cobos MI, Frosch M, Dickerson BC. A 63-Year-Old Man With Progressive Visual Symptoms. JAMA Neurol. 2017 Jan 1;74(1):114-118. doi: 10.1001/jamaneurol.2016.2210. PubMed PMID: 27842190. 7. Mesulam MM, Dickerson BC, Sherman JC, Hochberg D, Gonzalez RG, Johnson KA, Frosch MP. Case 1-2017. A 70-Year-Old Woman with Gradually Progressive Loss of Language. N Engl J Med. 2017 Jan 12;376(2):158-167. doi: 10.1056/NEJMcpc1613459. PubMed PMID: 28076711; PubMed Central PMCID: PMC5264551. 8. Ducharme S, Dickerson BC, Price BH. Improvement in athletic performance as an early symptom of behavioral variant frontotemporal dementia. J Neuropsychiatry Clin Neurosci 2015;27:e163- 164. 9. Evans WS, Quimby M, Dickey MW, Dickerson BC. Relearning and Retaining Personally- Relevant Words using Computer-Based Flashcard Software in Primary Progressive Aphasia. Front Hum Neurosci 2016;10:561. 10. Mitchell SB, Lucente D, Larvie M, Cobos MI, Frosch M, Dickerson BC. A 63-Year-Old Man With Progressive Visual Symptoms. JAMA Neurol 2017;74:114-118. 11. Veronelli L, Makaretz SJ, Quimby M, Dickerson BC, Collins JA. Geschwind Syndrome in frontotemporal lobar degeneration: Neuroanatomical and neuropsychological features over 9 years. Cortex 2017;94:27-38.

Professional educational materials or reports, in print or other media

1. Dickerson BC. Mild cognitive impairment (invited module for Stanford End-of-Life Web Curriculum project). 2008.

Narrative Report

My area of excellence is in Investigation. I have over 200 peer-reviewed publications (27,781 citations; h index 71, i10 index 165) in 3 major areas: 1) cognitive, affective, and imaging neuroscience in the healthy adult across the lifespan; 2) technology development in neuroimaging; and 3) the translation of innovative behavioral phenotyping and advanced imaging technology to patients with neurodegenerative disease. I am currently the principal investigator or co-principal investigator on seven R01, one R56 and one U19 NIH grants, with total direct costs for these grants at over $21 million dollars, and co-investigator on 7 54

multicenter NIH and foundation grants with total direct costs at over $56 million. With this support, we are making substantial progress in the three major areas of investigation summarized above. I have contributed as first or senior author to high impact publications in journals such as Brain, Nature Neuroscience, Nature Human Behavior, PNAS, and Journal of Neuroscience on the fundamental neuroanatomy and function of large-scale brain systems subserving memory, emotion, and social behavior in the healthy adult human brain and the effects of normal aging on these systems and the abilities they subserve. I have contributed and am continuing to contribute to the development and validation of novel methods for MRI data acquisition and analysis, simultaneous MR-PET studies of cerebral metabolism, dopaminergic function, neuroinflammation, and gene expression, and PET studies of novel ligands to measure tau pathology. Results of these studies have also been published in high impact journals, including Annals of Neurology, PNAS, Journal of Neuroscience, and Cerebral Cortex, and are making a substantial impact on the field. Finally, I have led high impact studies published in Brain, Annals of Neurology, PNAS, Journal of Neuroscience, Neurology, JAMA Neurology, and Journal of Neurology, Neurosurgery, and Psychiatry, and others on brain-behavior relationships and factors influencing the neurobiology and pathophysiology of Alzheimer’s disease, Primary Progressive Aphasia, Frontotemporal Dementia, Progressive Supranuclear Palsy, and other neurodegenerative diseases, as well as a variety of efforts to translate these measures into imaging biomarkers for use in diagnosis and outcomes as we move toward clinical trials of novel therapeutics for these devastating diseases. As a reflection of this research expertise, I have co-chaired the Charles River Association for Memory for more than 10 years, which brings together Boston-area investigators studying memory for an annual meeting. Also in part as a result of this research expertise, I was nominated and served as chair for the 2019 Alzheimer’s Imaging Consortium meeting, an highly regarded international annual research meeting of imaging investigators in the field that takes place at the Alzheimer’s Association International Conference. I have served on many NIH and North American foundation and international governmental research grant review panels. I was also nominated to chair the Research Platform session at the annual American Neuropsychiatric Association meeting for 3 years (2016-2018). In addition, I was invited to become Editor-in-Chief of Neuroimage: Clinical, a journal on the basic and applied imaging neuroscience of neuropsychiatric disorders, and I served a 3 year term.

In addition to research, I have also contributed substantially to Teaching. I have worked one-on-one in major mentorship roles with more than 60 mentees at a variety of levels, including serving on the dissertation committees of 11 graduate students, being primary mentor for 30 post-doctoral clinical or research fellows, and mentoring 8 individuals in the transition from post-doctoral trainees to junior faculty, including being primary mentor on four funded K career development awards. I give lectures in 4 HMS/HST courses that run annually or biennially, and lecture in 3 annual Harvard CME courses. For the past 9 years, I have co-directed the 3.5 day annual Harvard CME Dementia Course, now in its 24th year with a faculty of 20 and approximately 250-300 clinician attendees. I directed the American Academy of Neurology (AAN) Primer of Behavioral Neurology course for 5 years in a row, and have more recently directed the AAN Neurology of Social Behavior course.

In addition, I have an international reputation for Clinical Expertise, having contributed substantially to the diagnostic criteria for Frontotemporal Dementia (FTD), and developed two novel scales to measure the types and severity of symptoms in patients with FTD and Primary Progressive Aphasia. I have been asked to contribute chapters and editorials related to my clinical expertise by an international array of colleagues, and am on multiple corporate scientific advisory boards. I co-edited a widely regarded 2014 textbook Dementia: Comprehensive Principles and Practice (Oxford University Press), and edited a 2016 textbook Hodges’ Frontotemporal Dementia (Cambridge University Press), which has now become the definitive reference on these diseases. In part as a result of this clinical expertise, I was asked by the Chief 55

Scientific Officer of the Alzheimer’s Association to co-chair the Clinical Practice Guideline workgroup to develop best practices for the diagnostic evaluation of patients suspected of having Alzheimer’s disease.

Finally, I have made widely regarded contributions to the Education of Patients and Service to the Community. I am Chair of the Medical and Scientific Advisory Council of the Massachusetts/New Hampshire chapter of the Alzheimer’s Association, on which I have served for more than 9 years. I am Chair-Elect of the Medical and Scientific Advisory Council of the national Association for Frontotemporal Degeneration, the major grass roots organization supporting patients and families with these diseases. And I have run an annual FTD Patient and Caregiver Education day for the past 9 years which has brought together more than 100 New England-area patients and caregivers to learn about these diseases and their care and support. Finally, under my mentorship, Katie Brandt, the Care and Support Director for my Frontotemporal Disorders Unit, has been ambassador of the Massachusetts Rare Disease Day annual event for the past three years and was chosen in 2018 to be a member of the National Alzheimer’s Project Act Advisory Council, where she is now co-chair.