Proceedings OF THE National Academy of Sciences OF THE OF AMERICA

December 1988 Volume 85, Number 23 pp. 8771-9372 Table of Contents

AUTHOR INDEX ix

Physical Sciences MATHEMATICS Estimates for the d-Neumann problem for pseudoconvex domains in C2 of D. C. Chang, A. Nagel, and E. M. Stein 8771 finite type

Biological Sciences APPLIED BIOLOGICAL SCIENCES Milk lipid globules: Control of their size distribution H. Mohammed Valivullah, David R. 8775 Bevan, Alan Peat; and Thomas W. Keenan

BIOCHEMISTRY Energy metabolism of the untrained muscle of elite runners as observed by 31P Jane H. Park, Richard L. Brown, 8780 magnetic resonance spectroscopy: Evidence suggesting a genetic Charles R. Park, Mildred Cohn, and endowment for endurance exercise Determination of DNA structures by NMR and distance geometry techniques: Arthur Pardi, Dennis R. Hare, and 8785 A computer simulation Chuan Wang Detection of nucleic acid hybridization by nonradiative fluorescence resonance Richard A. Cardullo, Sudhir Agrawal, 8790 energy transfer Carlos Flores, Paul C. Zamecnik, and David E. Wolf

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Heteroatom-substituted fatty acid analogs as substrates for Robert 0. Heuckeroth, Luis Glaser, and 8795 N-myristoyltransferase: An approach for studying both the enzymology and Jeffrey I. Gordon function of protein acylation DNA damage-inducible transcripts in mammalian cells Albert J. Fornace, Jr., Isaac Alamo, Jr., 8800 and M. Christine Hollander Reduction of polygalacturonase activity in tomato fruit by antisense RNA Raymond E. Sheehy, Matthew Kramer, 8805 and William R. Hiatt Identification of a unique isoform of 1-aminocyclopropane-1-carboxylic acid Arkesh M. Mehta, Ramon L. Jordan, 8810 synthase by monoclonal antibody James D. Anderson, and Autar K. Mattoo Metal-specific synthesis of two metallothioneins and y-glutamyl peptides in R. K. Mehra, E. B. Tarbet, W. R. Gray, 8815 Candida glabrata and D. R. Winge Human papillomavirus type 16 cooperates with activated ras and fos oncogenes T. Crook, A. Storey, N. Almond, K. 8820 in the hormone-dependent transformation of primary mouse cells Osborn, and L. Crawford NF-KB protein purification from bovine spleen: Nucleotide stimulation and Michael J. Lenardo, Anna Kuang, Ann 8825 binding site specificity Gifford, and Evidence for a trans-acting factor that regulates the transcription of class II Andrew F. Calman and B. Matija 8830 major histocompatibility complex genes: Genetic and functional analysis Peterlin Identification of phosphorylated 422(aP2) protein as ppl5, the 15-kilodalton Richard C. Hresko, Michel Bernier, 8835 target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes Robert D. Hoffman, Jaime R. Flores-Riveros, Kan Liao, Don M. Laird, and M. Daniel Lane Cloning and nucleotide sequence of human y-glutamyl transpeptidase Ewa Rajpert-De Meyts, Nora 8840 Heisterkamp, and John Groffen Complete amino acid sequence of human placental protein 14: A Mervi Julkunen, Markku Seppala, and 8845 progesterone-regulated uterine protein homologous to f-lactoglobulins Olli A. Janne DNA gyrase binds to the family of prokaryotic repetitive extragenic Young Yang and Giovanna Ferro-Luzzi 8850 palindromic sequences Ames Signal transduction from membrane to cytoplasm: Growth factors and Deborah K. Morrison, David R. Kaplan, 8855 membrane-bound oncogene products increase Raf-1 and Ulf Rapp, and Thomas M. Roberts associated protein kinase activity A human 200-kDa protein binds selectively to DNA fragments containing G-T Josef Jiricny, Melya Hughes, Natalie 8860 mismatches Corman, and Brian B. Rudkin ,83y subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of Thomas M. Moriarty, Boaz Gillo, Donna 8865 phospholipase C J. Carty, Richard T. Premont, Emmanuel M. Landau, and Ravi Iyengar Reexamination of the kinetics of the transfer of NADH between its complexes P. B. Chock and H. Gutfreund 8870 with glycerol-3-phosphate dehydrogenase and with lactate dehydrogenase Adenosine regulates the Ca2+ sensitivity of mast mediator release Martin J. Lohse, Karl-Norbert Klotz, 8875 Manfred J. Salzer, and Ulrich Schwabe His-426 of the Pseudomonas aeruginosa exotoxin A is required for Daniel J. Wozniak, Leh-Yeh Hsu, and 8880 ADP-ribosylation of elongation factor II Darrell R. Galloway Additional low-abundance human small nuclear ribonucleoproteins: Karen A. Montzka and Joan A. Steitz 8885 U11, U12, etc. Pituitary-specific expression and glucocorticoid regulation of a Yves Tremblay, Irene Tretjakoff, Alan 8890 proopiomelanocortin fusion gene in transgenic mice Peterson, Tony Antakly, Cun Xian Zhang, and Jacques Drouin A nuclease that cuts specifically in the ribosome binding site of some T4 Marc Uzan, Renee Favre, and Edward 8895 mRNAs Brody Down-regulation of c-myb gene expression is a prerequisite for Kazuo Todokoro, Roger J. Watson, 8900 erythropoietin-induced erythroid differentiation Hiromi Higo, Hiroshi Amanuma, Satomi Kuramochi, Hiromi Yanagisawa, and Yoji Ikawa Different structures in the amino-terminal domain of the ornithine Jan P. Kraus, Jiff Novotn9, Frantisek 8905 transcarbamylase leader peptide are involved in mitochondrial import and Kalousek, Manju Swaroop, and Leon carboxyl-terminal cleavage E. Rosenberg ii Contents

Human DNA topoisomerase I is encoded by a single-copy gene that maps to Chung-Ching Juan, Jaulang Hwang, 8910 chromosome region 20q12-13.2 Angela A. Liu, Jacqueline Whang-Peng, Turid Knutsen, Kay Huebner, Carlo M. Croce, Hui Zhang, James C. Wang, and Leroy F. Liu cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Dale Hereld, Gerald W. Hart, and Paul 8914 Trypanosoma brucei T. Englund Phosphorylation of nitrogen regulator I (NRI) of Escherichia coli Verena Weiss and Boris Magasanik 8919 Cocrystal structure of an editing complex of Klenow fragment with DNA P. S. Freemont, J. M. Friedman, L. S. 8924 Beese, M. R. Sanderson, and T. A. Steitz Identification and purification of a Drosophila protein that binds to the terminal Donald C. Rio and Gerald M. Rubin 8929 31-base-pair inverted repeats of the P transposable element Probing the Escherichia coli glnALG upstream activation mechanism in vivo Selina Sasse-Dwight and Jay D. Gralla 8934 Characterization of the minor groove environment in a drug-DNA complex: Renzhe Jin and Kenneth J. Breslauer 8939 Bisbenzimide bound to the poly[d(AT)]-poly[d(AT)]duplex A mutant human proinsulin is secreted from islets of Langerhans in increased Raymond J. Carroll, Robert E. Hammer, 8943 amounts via an unregulated pathway Shu Jin Chan, Hewson H. Swift, Arthur H. Rubenstein, and Donald F. Steiner Isolation of a full-length cDNA insert encoding human aromatase system C. Jo Corbin, Sandra Graham-Lorence, 8948 cytochrome P-450 and its expression in nonsteroidogenic cells Michael McPhaul, J. Ian Mason, Carole R. Mendelson, and Evan R. Simpson SecA suppresses the temperature-sensitive SecY24 defect in protein James P. Fandl, Robert Cabelli, Donald 8953 translocation in Escherichia coli membrane vesicles Oliver, and Phang C. Tai Inhibition of HW-transporting ATPase by formation of a tight nucleoside J. Lunardi, A. Dupuis, J. Garin, J.-P. 8958 diphosphate-fluoraluminate complex at the catalytic site Issartel, L. Michel, M. Chabre, and P. V. Vignais Multiple genes encode nuclear factor 1-like proteins that bind to the promoter Gregorio Gil, Jeffrey R. Smith, Joseph 8963 for 3-hydroxy-3-methylglutaryl-coenzyme A reductase L. Goldstein, Clive A. Slaughter, Kim Orth, Michael S. Brown, and Timothy F. Osborne Dual mechanism of repression at a distance in the lac operon Yehuda Flashner and Jay D. Gralla 8968 Promoters largely determine the efficiency of repressor action Michael Lanzer and Hermann Bujard 8973 Purified SecB protein of Escherichia coli retards folding and promotes Judith B. Weiss, Paul H. Ray, and Philip 8978 membrane translocation of the maltose-binding protein in vitro J. Bassford, Jr. Characterization of a cDNA clone encoding the calmodulin-binding domain of Randall L. Kincaid, Maria S. 8983 mouse brain calcineurin Nightingale, and Brian M. Martin Structure and nucleotide sequence of the rat intestinal vitamin D-dependent Johann Krisinger, Hisham Darwish, 8988 calcium binding protein gene Noboya Maeda, and Hector F. DeLuca Polyomavirus early-late switch is not regulated at the level of transcription Robin Hyde-DeRuyscher and Gordon G. 8993 initiation and is associated with changes in RNA processing Carmichael Rapid production of full-length cDNAs from rare transcripts: Amplification Michael A. Frohman, Michael K. Dush, 8998 using a single gene-specific oligonucleotide primer and Gail R. Martin Relationship between transient DNA hypomethylation and erythroid Aharon Razin, Alex Levine, Tal Kafri, 9003 differentiation of murine erythroleukemia cells Sergio Agostini, Tomaharu Gomi, and Giulio L. Cantoni Efficient transactivation and morphologic transformation by bovine Jeffrey Settleman and Daniel DiMaio 9007 papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus

BIOPHYSICS Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: H. Komiya, T. 0. Yeates, D. C. Rees, 9012 Symmetry relations and sequence comparisons between different species J. P. Allen, and G. Feher Ca2+ transient, Mg2+, and pH measurements in the cardiac cycle by 19F NMR Heidi L. Kirschenlohr, James C. 9017 Metcalfe, Peter G. Morris, Glenn C. Rodrigo, and Gerry A. Smith

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Two-dimensional protonic percolation on lightly hydrated purple membrane John A. Rupley, Linda Siemankowski, 9022 Giorgio Careri, and Fabio Bruni

BOTANY Transformation of the cryobehavior of rye protoplasts by modification of the Peter L. Steponkus, Matsuo Uemura, 9026 plasma membrane lipid composition Ronald A. Balsamo, Tudor Arvinte, and Daniel V. Lynch The dominant non-gibberellin-responding dwarf mutant (D8) of maize Shozo Fujioka, Hisakazu Yamane, Clive 9031 accumulates native gibberellins R. Spray, Masayuki Katsumi, Bernard 0. Phinney, Paul Gaskin, Jake MacMillan, and Nobutaka Takahashi Evidence for N- and C-terminal processing of a plant defense-related : H. Shinshi, H. Wenzler, J.-M. Neuhaus, 9036 Primary structure of tobacco prepro-j3-1,3-glucanase (Correction) G. Felix, J. Hofsteenge, and F. Meins, Jr.

CELL BIOLOGY Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene- Shimon Efrat, Susanne Linde, Hans 9037 oncogene Kofod, David Spector, Michael Delannoy, Seth Grant, Douglas Hanahan, and Steinunn Baekkeskov Evidence for expression of the facilitated glucose transporter in rat hepatocytes David B. Rhoads, Mikihisa Takano, 9042 Sebastiano Gattoni-Celli, Chia-Chen Chen, and Kurt J. Isselbacher Decreased de novo synthesis of proteoglycans in drug-induced renal cystic Brigitte Lelongt, Frank A. Carone, and 9047 disease Yashpal S. Kanwar Selective and indirect modulation of human multipotential and erythroid Hal E. Broxmeyer, Li Lu, Scott Cooper, 9052 hematopoietic progenitor cell proliferation by recombinant human activin Ralph H. Schwall, Anthony J. Mason, and inhibin and Karoly Nikolics Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced Kiyoko Fukami, Koozi Matsuoka, 9057 mitogenesis Osamu Nakanishi, Akio Yamakawa, Sadaaki Kawai, and Tadaomi Tanenawa Multiple protein 4.1 isoforms produced by alternative splicing in human John G. Conboy, Jefferson Chan, Narla 9062 erythroid cells Mohandas, and Yuet W. Kan Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of Michie Nakayasu, Hiroshi Shima, Shizu 9066 poly(ADP-ribose) polymerase Aonuma, Hitoshi Nakagama, Minako Nagao, and Takashi Sugimura cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase Paul G. Grant, Anthony F. Mannarino, 9071 markedly stimulates its catalytic activity and Robert W. Colman Conditional enhancement of liver-specific gene transcription Kenneth S. Zaret, C. Michael DiPersio, 9076 David A. Jackson, William J. Montigny, and Debra L. Weinstat Isolation and sequence determination of a cDNA clone for rat peroxisomal P. Gopal Reddy, Mohan R. Nemali, M. 9081 urate oxidase: Liver-specific expression in the rat Kumudavalli Reddy, M. Narahari Reddy, Pau M. Yuan, Sylvia Yuen, Thomas G. Laffler, Teruaki Shiroza, Howard K. Kuramitsu, Nobuteru Usuda, Rex L. Chisholm, M. Sambasiva Rao, and Janardan K. Reddy Defining cellular senescence in IMR-90 cells: A flow cytometric analysis Steven W. Sherwood, Daphne Rush, 9086 Jeffrey L. Ellsworth, and Robert T. Schimke

DEVELOPMENTAL BIOLOGY Erythropoietin changes the globin program of an interleukin 3-dependent Tariq Enver, Betty Nakamoto, Joyce 9091 multipotential cell line Karlinsey, Betty Josephson, Joel Greenberger, and Thalia Papayannopoulou Glucocorticoids both stimulate and inhibit production of pulmonary surfactant Helen G. Liley, R. Tyler White, Bradley 9096 protein A in fetal human lung J. Benson, and Philip L. Ballard iv Contents

EVOLUTION Tandemly repeated tRNA pseudogenes in photobacterium Sylvie Giroux and Robert Cedergren 9101 Analysis of pivotal-differential evolutionary patterns Gordon Kimber and Yang Yen 9106

GENETICS Amino acid changes linked to pyrimethamine resistance in the dihydrofolate Alan F. Cowman, Mary J. Morry, 9109 reductase-thymidylate synthase gene of Plasmodium falciparum Beverly A. Biggs, George A. M. Cross, and Simon J. Foote Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase David S. Peterson, David Walliker, and 9114 confers resistance to pyrimethamine in falciparum malaria Thomas E. Wellems Admixture as a tool for finding linked genes and detecting that difference from Ranajit Chakraborty and Kenneth M. 9119 allelic association between loci Weiss Overproduction of the e subunit of DNA polymerase III counteracts the SOS Piotr Jonczyk, Iwona Fijalkowska, and 9124 mutagenic response of Escherichia coli Zygmunt Ciesla Evidence for a single rolling circle in the replication of potato spindle tuber Andrea D. Branch, Bonnie J. Benenfeld, 9128 viroid and Hugh D. Robertson Synthesis of an opine-like compound, a rhizopine, in alfalfa nodules is Peter J. Murphy, Nina Heycke, Stefan P. 9133 symbiotically regulated Trenz, Pascal Ratet, Frans J. de Bruijn, and Jeff Schell ' Fluorescence in situ hybridization with human chromosome-specific libraries: D. Pinkel, J. Landegent, C. Collins, J. 49138 ) Detection of trisomy 21 and translocations of chromosome 4 Fuscoe, R. Segraves, J. Lucas, and J. Gray A sensitive molecular assay for mutagenesis in mammalian cells: Reversion Lawrence M. Gelbert and Richard L. 9143 analysis in cells with a mutant shuttle vector gene integrated into Davidson chromosomal DNA Structure and chromosomal localization of the functional intronless human Kazue Hattori, Peter Angel, Michelle M. 9148 JUN protooncogene Le Beau, and Michael Karin Intrachromosomal rearrangements mediated by hobo transposons in Drosophila Johng L. Lim 9153 melanogaster / Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC Lawrence R. Finger, Kay Huebner, fusion transcript Linda A. Cannizzaro, Kelly McLeod, Peter C. Nowell, and Carlo M. Croce

Escherichia coli mutY gene product is required for specific A-G -. CG K. G. Au, M. Cabrera, J. H. Miller, and 9163 mismatch correction Paul Modrich High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea L. B. Russell, J. W. Bangham, K. F. 9167 exposure of mouse zygotes Stelzner, and P. R. Hunsicker t-,Analysis of a T-cell tumor-specific breakpoint cluster at human Laurel Mengle-Gaw, Donna G. chromosome 14q32 Albertson, Paul D. Sherrington, and Terence H. Rabbitts M13 repeat probe detects DNA minisatellite-like sequences in gymnosperms Steven H. Rogstad, John C. Patton II, 9176 and angiosperms and Barbara A. Schaal

IMMUNOLOGY Release of IgD-binding factor by T cells under the influence of interleukin 2, Ashok R. Amin, Richard F. Coico, Fred 9179 interleukin 4, or cross-linked IgD Finkelman, Gregory W. Siskind, and G. Jeanette Thorbecke

An analysis of T-cell receptor variable region gene expression in major Jerome Bill, Virginia B. Appel, and Ed 9184 histocompatibility complex disparate mice Palmer

Coexpression of granulocyte-macrophage colony-stimulating factor, y Anne Kelso and Nicholas M. Gough 9189 interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide Andrew J. McMichael, Frances M. 9194 epitope by cytotoxic T lymphocytes Gotch, Jesus Santos-Aguado, and Jack L. Strominger

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Synthesis and expression in Escherichia coli of the gene encoding Ivan Lindley, Heinz Aschauer, 9199 monocyte-derived neutrophil-activating factor: Biological equivalence Jan-Marcus Seifert, Charles Lam, between natural and recombinant neutrophil-activating factor Waltraud Brunowsky, Eckhard Kownatzki, Marcus Thelen, Paola Peveri, Beatrice Dewald, Vinzenz von Tscharner, Alfred Walz, and Marco Baggiolini Anti-immunoglobulin pretreatment induces a calcium-mobilization response to Cosmas I. Kalunta, John S. Kaptein, 9204 the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi Helen Niedzin, Stephen J. Scott, lymphoblastoid cells G. H. Daniel Lee, and Pramod M. Lad Expression of CD3-associated antigen-binding receptors on suppressor T cells Vijay K. Kuchroo, J. Kevin Steele, Paul 9209 R. Billings, Periasamy Selvaraj, and Martin E. Dorf Formation of IgE-binding factors by T cells of patients infected with human Claudio Carini, Joseph Margolick, Junji 9214 immunodeficiency virus type 1 Yodoi, and Kimishige Ishizaka

MEDICAL SCIENCES Recombinant tumor necrosis factor increases pulmonary vascular permeability Christopher J. Horvath, Thomas J. 9219 independent of neutrophils Ferro, Gary Jesmok, Asrar B. Malik Missense mutations in an infectious human immunodeficiency viral genome: M. Reza Sadaie, Jay Rappaport, Thomas 9224 Functional mapping of tat and identification of the rev splice acceptor Benter, Steven F. Josephs, Rudolph Willis, and Flossie Wong-Staal Aminosugar derivatives as potential anti-human immunodeficiency virus agents Abraham Karpas, George W. J. Fleet, 9229 Raymond A. Dwek, Sigthor Petursson, Sung K. Namgoong, Nigel G. Ramsden, Gary S. Jacob, and Thomas W. Rademacher Effects of passive immunization in patients with the acquired Abraham Karpas, Fergal Hill, Michael 9234 immunodeficiency syndrome-related complex and acquired Youle, Vivienne Cullen, Jim Gray, immunodeficiency syndrome Nigel Byron, Frank Hayhoe, Melinda Tenant-Flowers, Linda Howard, Denise Gilgen, John K. Oates, David Hawkins, and Brian Gazzard Purification and characterization of a bovine acetyl low density lipoprotein Tatsuhiko Kodama, Pranhitha Reddy, 9238 receptor Chiharu Kishimoto, and Monty Krieger Detection of benzo[a]pyrene diol epoxide-DNA adducts in human placenta David K. Manchester, Ainsley Weston, 9243 Jin-Su Choi, Glenwood E. Trivers, Paul V. Fennessey, Elaine Quintana, Peter B. Farmer, Dean L. Mann, and Curtis C. Harris Role of protein N-glycosylation in pathogenesis of human immunodeficiency David C. Montefiori, W. Edward 9248 virus type 1 Robinson, Jr., and William M. Mitchell Human granulocyte-macrophage colony-stimulating factor is a growth factor Shoukat Dedhar, Louis Gaboury, Paula 9253 active on a variety of cell types of nonhemopoietic origin Galloway, and Connie Eaves Localization of human ERBA2 to the 3p22--3p24.1 region of chromosome 3 H. Drabkin, F.-T. Kao, J. Hartz, I. 9258 and variable deletion in small cell lung cancer Hart, A. Gazdar, C. Weinberger, R. Evans, and M. Gerber Even transcriptionally competent proviruses are silent in bovine leukemia Anne Van den Broeke, Yvette Cleuter, 9263 virus-induced sheep tumor cells Gao Chen, Daniel Portetelle, Marc Mammerickx, Daniel Zagury, Michele Fouchard, Laure Coulombel, Richard Kettmann, and Arsene Burny Analysis of RAS oncogene mutations in human lymphoid malignancies Antonino Neri, Daniel M. Knowles, 9268 Angela Greco, Frank McCormick, and Riccardo Dalla-Favera Binding region for human immunodeficiency virus (HIV) and epitopes for Tamio Mizukami, Thomas R. Fuerst, 9273 HIV-blocking monoclonal antibodies of the CD4 molecule defined by Edward A. Berger, and Bernard Moss site-directed mutagenesis Fetal hemoglobin synthesis in vivo: Direct evidence for control at the level of Tsukuru Umemura, Adil Al-Khatti, 9278 erythroid progenitors Thalia Papayannopoulou, and George Stamatoyannopoulos

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Processing of the structural proteins of human immunodeficiency virus type 1 Ranajit Pal, Robert C. Gallo, and M. G. 9283 in the presence of monensin and cerulenin Sarngadharan Juxtaposition of the T-cell receptor a chain locus (14q11) and a region (14q32) Michael P. Davey, Virginia Bertness, 9287 of potential importance in leukemogenesis by a 14;14 translocation in a Kenneth Nakahara, John P. Johnson, patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia 0. Wesley McBride, Thomas A. Waldmann, and Ilan R. Kirsch Reversion toward an earlier stage of differentiation and loss of polarity during Renato Dulbecco, Barbara Armstrong, 9292 progression of N-methyl-N-nitrosourea-induced rat mammary tumors and Ross Allen Stress-induced alterations of immunity in hypophysectomized rats Steven E. Keller, Steven J. Schleifer, 9297 Anthony S. Liotta, Ronald N. Bond, Nauder Farhoody, and Marvin Stein Aberrant expression of receptors for platelet-derived growth factor in an Nils-Erik Heldin, Bengt Gustavsson, 9302 anaplastic thyroid carcinoma cell line Lena Claesson-Welsh, Annet Hammacher, Joachim Mark, Carl-Henrik Heldin, and Bengt Westermark Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant Joseph M. Ahearn, S. Diane Hayward, 9307 human EBV/C3d receptor John C. Hickey, and Douglas T. Fearon Transformation of an interleukin 3-dependent hematopoietic cell line by the George Q. Daley and David Baltimore 9312 chronic myelogenous leukemia-specific P210bcr/ab1 protein

MICROBIOLOGY Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella Malabi M. Venkatesan, Jerry M. Buysse, 9317 flexneri and Dennis J. Kopecko NEUROBIOLOGY Mammalian cerebral cortical tissue responds to low-intensity visible light Patricia D. Wade, Jonathan Taylor, and 9322 Philip Siekevitz Suppression and induction of epileptic activity by neuronal grafts G. Buzsaki, G. Ponomareff, F. Bayardo, 9327 T. Shaw, and F. H. Gage Localization of glucocorticoid receptor mRNA in the male rat brain by in situ Marie Aronsson, Kjell Fuxe, Yu Dong, 9331 hybridization Luigi F. Agnati, Sam Okret, and Jan-Ake Gustafsson Patch-clamp study of y-aminobutyric acid receptor Cl- channels in cultured Joachim Bormann and Helmut 9336 astrocytes Kettenmann Measurement of local cerebral protein synthesis in vivo: Influence of recycling C. Beebe Smith, G. E. Deibler, N. Eng, 9341 of amino acids derived from protein degradation K. Schmidt, and L. Sokoloff Long-term potentiation differentially affects two components of synaptic Dominique Muller and Gary Lynch 9346 responses in hippocampus Antiserum raised against residues 159-168 of the guanine nucleotide-binding Roser Cortes, Tomas Hokfelt, Martin 9351 protein Gi3-a reacts with ependymal cells and some neurons in the rat brain Schalling, Menek Goldstein, Paul containing cholecystokinin- or cholecystokinin- and tyrosine Goldsmith, Allen Spiegel, Cecilia 3-hydroxylase-like immunoreactivities Unson, and John Walsh Long-term sensitization in Aplysia increases the number of presynaptic Craig H. Bailey and Mary Chen 9356 contacts onto the identified gill motor neuron L7

PHYSIOLOGICAL SCIENCES Guanosine 5'-monophosphate modulates gating of high-conductance David L. Williams, Jr., George M. Katz, 9360 Ca2+-activated K+ channels in vascular smooth muscle cells Lydie Roy-Contancin, and John P. Reuben Vasopressin modulates the spontaneous electrical activity in aortic cells (line Catherine Van Renterghem, Georges 9365 A7r5) by acting on three different types of ionic channels Romey, and Michel Lazdunski

POPULATION BIOLOGY Classification of the European language families by genetic distance Rosalind M. Harding and Robert R. 9370 Sokal

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