Medidrug® Reference Materials Clinical and Forensic

Medidrug ® reference materials Clinical and Forensic Toxicology

Alcohol VII - Consumption Markers – Hair 2018-04 1.7

Reference materials from cut hair for quality assurance of quantitative analyses

The unique quality of these matrix reference materials is setting a new standard for hair analyses. 1 mm The manufacturing principle is based upon a special procedure for reliable and non-destructive homogenization of hair fibres : Without milling and thus without the loss of their structural integrity. A precisely defined cutting length allows that after reduction, each processed hair fibre is present in extremely uniform segments of 1 mm length.

® Medidrug ALCM H-a (authentic) GC-MS(-MS), LC-MS(-MS)

Authentic cut reference material for determination of alcohol consumption markers in hair, manufactured from hair of European alcoholic beverage consumers. It is appropriate for method development and validation as well as for internal quality control. Compared to milled or spiked hair samples these reference material can be washed too. This assures a comprehensive quality control for the entire analytical process. The yield of ethyl glucuronide extracts from these reference material is to be monitored (please see following information). The target values have been established within the bounds of the proficiency tests by the Society of Hair Testing SoHT in cooperation with the Federal Institute for Materials Research and Testing (BAM) and MEDICHEM. The samples’ homogeneity has been controlled under repeatability conditions.

Important information: At present most extraction methods tend to an insufficient yield of ethyl glucuronide. This observation from the proficiency testing 2012 by the SoHT gave reason to re-test several sample lots from 2011 & 2012 within the bounds of the succeeding proficiency testing in 2013. This time however the participating laboratories received not only cut but also milled samples for the interlaboratory test. This re-test confirmed: A major- ity of laboratories reported a significantly higher ethyl glucuronide yield extracted from milled hair compared to the extraction from cut hair samples – partly in a sizeable amount! A new value assignment has been carried out for these sample lots, solely based upon extracts of milled hair samples (see below). This reflects the updated comment by the SoHT regarding the quantification of EtG in hair for alcohol abuse confirmation (please see SoHT-meeting in Bordeaux 2014).

Medidrug ® Basis-line H

Authentic reference material, made from hair of European donors. For base-line determination in different applications or as negative control for 1) ethyl glucuronide and 37 more components .

Medidrug ® Hair – authentic

ALCM series H-a Basis-line H-a Alcohol consumption markers 5 analytes 38 analytes 1)

1/11-B 1/11-C 12-A 12-B 14-A 14-B Analyte Unit NEG Re-Test:13-F Re-Test:13-G Re-Test:13-H Re-Test:13-I PT: 2014 PT: 2014

21,6 2) 12,4 2) 38,7 2) 68,6 2) Ethyl glucuronide Pg/mg 8,5 4) 28,8 4) < LOD 27,0 3) 22,9 3) 50,6 3) 82,5 3)

Ethyl myristate Pg/mg 250 6) 69 6) 394 5) 54 5) 25 7) 363 7)

Ethyl oleate Pg/mg 1348 6) 867 6) 1718 5) 233 5) 171 7) 1046 7)

Ethyl palmitate Pg/mg 483 6) 274 6) 875 5) 181 5) 108 7) 571 7) -

Ethyl stearate Pg/mg 74 6) 132 6) 231 5) 30 5) 54 7) 100 7)

Fatty acid ethyl esters, total Pg/mg 2155 6) 1342 6) 3218 5) 498 5) 358 7) 2080 7)

Order Information REF REF REF REF REF REF REF

1 x 100 mg (vial) 15HR01VA 15HR02VA 15HR03VA 15HR04VA 15HR10VA 15HR11VA 00HL00VA

1 x 300 mg (vial) 15HR01XA 15HR02XA 15HR03XA 15HR04XA 15HR10XA 15HR11XA 00HL00XA

LOT LOT LOT LOT LOT LOT

- New - - New -

1) Amphetamines, benzodiazepines, cannabinoids, cocaine, opioid substitution drugs, opiates 2) Previous target values (proficiency tests 2011 resp. 2012), measurements predominantly based upon extractions without previous milling 3) New determined target values (proficiency test 2013); solely based on extraction of previous milled hair samples 4) Proficiency Test 2014: The determinations are solely based on extraction of previous milled hair samples 5) We have not specified any target values: The indicated values (without washing, PT 2012) are meant to be a guideline. For details: see information leaflet! 6) New guide values (without washing) after re-test within bounds of proficiency test in 2013 7) We have not specified any target values: The indicated values (without washing, PT 2014) are meant to be a guideline. For details: see information leaflet!

LOT The catalogue code (REF) of products marked with this symbol defines a singular lot (batch) which has been produced especially for an external quality control (proficiency testing). After expiry of the validity or after being sold out this product is no longer available. New lots with similar compositions of components will be offered with a different catalog code. If the material has been approved by the direction of proficiency testing according to the orga- nizing association or reference institution and thus get an internal quality control we proceed in this manner.

The provided mixture of the controls and their respective analyte concentrations are for overview purposes Contact us: only and may differ from the current available batches. For the internal quality control, only the designated specification of the respective batch of the information leaflet is valid. ) + 49 (0)7157 / 5304 - 100

All products conform to IVD Directive 98/79/EC + 49 (0)7157 / 5304 - 11

IVD 6 B Certified quality management according to DIN EN ISO 9001:2015 [email protected] DIN EN ISO 13485:2016 :

71144 Steinenbronn GERMANY

Medidrug ® reference materials Clinical and Forensic Toxicology

Alcohol VII – Consumption Markers – Hair 2014-07 1.7

® Medidrug FAEE H-i (in vitro incorporated) GC-MS(-MS), LC-MS(-MS)

Incorporated* cut hair reference material for determination of fatty acid ethyl esters in hair, prepared form hair of European hair donors. It is suitable for method development and validation as well as for internal quality control. Contrary to milled hair samples this reference material can be washed, allowing a comprehensive control of quality for the entire analytical process. The target values have been assessed within the bounds of the proficiency testing by the Society of Hair Testing SoHT in cooperation with the Federal Institute for Materials Research and Testing (BAM) and MEDICHEM. The samples’ homogeneity has been verified under repeatability conditions.

* in vitro incorporation

® Medidrug Hair – incorporated

1) FAEE series H-i Fatty Acid Ethyl Esters 4 analytes

12-E 12-F Analyte Unit 12-C 12-D Re-test: 13-C Re-test: 13-D

2) 2) 2) 2) 63 115 Ethyl myristate pg/mg 16 36 3) 3) 59 121

2) 2) 2) 2) 262 460 Ethyl oleate pg/mg 34 160 3) 3) 282 556

2) 2) 2) 2) 243 465 Ethyl palmitate pg/mg 17 142 3) 3) 326 608

2) 2) 2) 2) 77 129 Ethyl stearate pg/mg 22 55 3) 3) 71 144

2) 2) 2) 2) 645 1169 Fatty acid ethyl esters, total pg/mg 89 393 3) 3) 738 1429

Order information REF REF REF REF

1 x 50 mg (vial) 15HR06UA 15HR07UA 15HR08UA 15HR09UA

LOT LOT LOT LOT

1) Target values have not been specified: the indicated values (without washing) are meant to be a guideline. Details: see information leaflet! 2) Guide values determined within the bounds of the proficiency test in 2012 3) New guide values determined after re-test within the bounds of the proficiency test in 2013

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All products conform to IVD Directive 98/79/EC + 49 (0)7157 / 5304 - 11

IVD 6 B Certified quality management according to DIN EN ISO 9001:2015 [email protected] DIN EN ISO 13485:2016 :

71144 Steinenbronn GERMANY

Medidrug ® reference materials Clinical and Forensic Toxicology

Alcohol VII – Consumption Markers – Hair 2020-07 1.7

® Medidrug EtG H-d (spiked) LC-MS(-MS)

Gravimetrically spiked cut reference material for determination of ethyl glucuronide in hair, prepared from hair of European hair donors. The reference material is suitable for internal quality control of the determination of ethyl glucuronide in hair. The gravimetric spiking has been verified by the BAM Federal Institute for Materials Research and Testing performing multiple determinations .

® Medidrug Hair – spiked

EtG H-d Ethyl Glucuronide 1 analyte

Analyte Unit 000 004 005 007 020 025 030 040 50 100 200

Ethyl Glucuronide pg/mg < LOD 4 5 7 20 25 30 40 50 100 200

Order Information REF REF REF REF REF REF REF REF REF REF REF

1 x 100 mg (vial) 15HL00VA 15HL02VA 15HL03VA 15HL04VA 15HL06VA 15HL07VA 15HL08VA 15HL09VA 15HL10VA 15HL11VA 15HL12VA

10 x 100 mg (vial) 15HL00VF 15HL02VF 15HL03VF 15HL04VF 15HL06VF 15HL07VF 15HL08VF 15HL09VF 15HL10VF 15HL11VF 15HL12VF

New level Ó Ó Ó Ó Ó Ó Ó Ó New item New item New item New item New item New item New item New item

number number number number number number number number

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All products conform to IVD Directive 98/79/EC + 49 (0)7157 / 5304 - 11

IVD 6 B Certified quality management according to DIN EN ISO 9001:2015 [email protected] DIN EN ISO 13485:2016 :

71144 Steinenbronn GERMANY

Medidrug ® Reference Materials Clinical and Forensic Toxicology

Drugs of Abuse II – Hair 2020-05 1.11

Hair reference materials from cut hair Medidrug ® DOA 14 H-d, Level 0-6 - New - GC-MS(-MS), LC-MS(-MS) for quality monitoring of quantitative analyses Lot series of extremely homogeneous hair reference materials in 7 relevant concentration

The unique quality of these matrix reference materials is setting a levels, prepared from one single, meticulously homogenized drug-free hair pool of cut Euro- new standard for hair analyses. The manufacturing principle is pean human hair. These divided lots have been spiked gravimetrically with 47 drugs of abuse and their metabolites and MPPH as additive: based upon a special procedure for reliable and non-destructive homogenization of hair fibres : Without milling and thus without L0 Negativ Control the loss of their structural integrity. A precisely defined cutting L1 Near the limits of quantification or detection (method-dependent) length allows that after reduction, each processed hair fibre is L2-4 In the cut-off ranges of different international professional societies © present in extremely uniform segments of 1 mm length. L5-6 Elevated ranges

© EWDTS (The European Workplace Drug Testing Society), GTFCh (Gesellschaft für Toxikologische und Forensische Chemie), SFTA (Société Française de Toxicologie Analytique), SGRM (Schweizerische Gesellschaft für Rechtsmedizin), SoHT (Society of Hair Testing)

Medidrug ® Hair – spiked

DOA 14 H-d Drugs of Abuse 47 analytes

Group Analytes Unit L0 L1 L2 L3 L4 L5 L6 Amphetamines Amphetamine pg/mg 0 60,0 120 240 511 1110 2030 MBDB pg/mg 0 57,4 115 230 489 1060 1940 MDA pg/mg 0 60,2 121 241 513 1120 2030 MDE(A) pg/mg 0 60,1 120 241 512 1110 2030 MDMA pg/mg 0 60,4 121 242 515 1120 2040 Methamphetamine pg/mg 0 60,0 120 240 512 1110 2030 Benzodiazepines Alprazolam pg/mg 0 2,53 22,8 63,4 252 585 1060 + Z-Drugs OH-Alprazolam pg/mg 0 1,73 15,6 43,4 173 400 728 7-Aminoclonazepam pg/mg 0 2,38 21,5 59,7 238 552 1000 7-Aminoflunitrazepam pg/mg 0 2,38 21,5 59,6 237 551 1000 Bromazepam pg/mg 0 2,40 21,6 60,1 239 555 1010 Diazepam (Valium) pg/mg 0 2,39 21,6 60,0 239 554 1010 Flunitrazepam pg/mg 0 2,42 21,8 60,7 241 560 1020 Lorazepam pg/mg 0 2,38 21,5 59,6 237 550 1000 Midazolam pg/mg 0 2,46 22,2 61,6 245 568 1030 Nordiazepam pg/mg 0 2,39 21,6 59,9 238 553 1010 Oxazepam pg/mg 0 2,38 21,5 59,7 238 552 1000 Temazepam pg/mg 0 2,38 21,5 59,6 237 550 1000 Zolpidem pg/mg 0 2,36 21,3 59,1 235 546 994 Cannabinoides THC pg/mg 0 12,0 28,0 60,0 245 556 1010 CBD (Cannabidiol) pg/mg 0 24,0 55,9 120 253 558 1020 CBN (Cannabinol) pg/mg 0 24,0 55,9 120 252 557 1020 THC-COOH ** pg/mg 0 6,00 14,0 30,0 123 278 506 Cocaine Anhydroecgonine methyl ester pg/mg 0 25,3 58,9 126 515 1170 2670 Benzoylecgonine pg/mg 0 23,7 55,3 118 486 1100 4990 Cocaethylene pg/mg 0 24,2 56,3 120 492 1120 2550 Cocaine pg/mg 0 60,0 240 600 2417 5560 10100 Ecgonine methyl ester pg/mg 0 24,0 55,9 120 491 1110 5050 Norcocaine pg/mg 0 24,1 56,1 120 491 1110 2540 Hallucinogenes Ketamine pg/mg 0 24,2 56,3 121 493 1120 2550 Norketamine pg/mg 0 24,0 55,8 120 488 1110 2530 LSD pg/mg 0 6,27 25,1 62,7 253 581 1060 Phencyclidine pg/mg 0 27,7 64,4 138 566 1280 5810 Opioids Codeine pg/mg 0 60,0 120 240 512 1110 2030 Dihydrocodeine pg/mg 0 60,2 120 241 513 1120 2030 Fentanyl pg/mg 0 5,97 23,9 59,8 241 554 1010 Hydromorphone pg/mg 0 23,7 55,3 118 250 551 1010 Morphine pg/mg 0 59,0 118 236 503 1090 1990 6-MAM pg/mg 0 58,9 118 236 502 1090 1990 Norfentanyl pg/mg 0 0,59 5,35 14,9 59,2 137 250 Oxymorphone pg/mg 0 24,1 56,1 120 253 559 1020 Tilidine pg/mg 0 23,9 55,6 119 251 555 1010 Tramadol pg/mg 0 23,9 55,7 119 487 1100 2520 Substitution Buprenorphine pg/mg 0 5,98 23,9 59,9 241 555 1010 Norbuprenorphine pg/mg 0 5,97 23,9 59,7 241 554 1010 Methadone pg/mg 0 60,4 121 242 515 1120 2040 EDDP pg/mg 0 24,0 55,9 120 491 1110 5040 Additive MPPH pg/mg 0 1053 1054 1009 1054 1017 932

Order Information REF REF REF REF REF REF REF

1 x 100 mg (vial) 24HL00VA 24HL01VA 24HL02VA 24HL03VA 24HL04VA 24HL05VA 24HL06VA

LOT LOT LOT LOT LOT LOT LOT

LOT Proficiency test control which catalogue code (REF) defines a singular lot (batch). After expiry of the validity or after being sold out this product is no longer available. New lots with similar compositions of components will be offered with a different catalog code.

** The concentraions for THC-COOH – which are too high - do not correspond to the normal measurement ranges.

All products conform to IVD Directive 98/79/EC + 49 (0)7157 / 5304 - 11

IVD 6 B Certified quality management according to DIN EN ISO 9001:2015 [email protected] DIN EN ISO 13485:2016 :

71144 Steinenbronn GERMANY

Medidrug ® Reference Materials Clinical and Forensic Toxicology

Blank Matrices – Hair / Serum / Urine / Whole Blood 2020-07 1.13

For quality monitoring of quantitative measurements Medidrug ® Basis-line H GC-MS, HPLC, LC-MS

Authentic hair reference material, prepared from multiple European hair donors and ho- These reference materials are produced on the basis of mogenized by cutting into pieces of 1 mm. For negative control of analytical procedures in human matrices. The highly accurate manufacturing hair as well as for base-line determination in different applications in analytical laboratories. occurs in a very gentle way. Analytical matrix effects are Medidrug ® Basis-line S / U / VB almost excluded. We achieve this by granting a maximal conformity of the products’ matrix with the matrix of the Lyophilized serum-, urine- or whole blood-based reference material. For base-line determina- patients’ sample. tion in different applications or as negative control.

Medidrug ® Hair Serum Urine Whole Blood

Blank Matrices Basis-line H-a Basis-line S Basis-line U Basis-line VB

Analyte Groups 38 analytes 91 analytes 71 analytes 70 analytes

Alcohol Consumption EtG (Ethyl glucuronide) Ethanol EtG (Ethyl glucuronide), Markers EtS (Ethyl sulfate)

Amines / Amphetamine, MDA, MDE (MDEA), Amphetamine, MBDB, MDA, Amphetamine, MBDB, MDA, Amphetamine, MBDB, MDA, Amphetamines MDMA („Ecstasy“), Methamphetamine MDE (MDEA), MDMA („Ecstasy“), MDE (MDEA), MDMA („Ecstasy“), MDE (MDEA), MDMA („Ecstasy“), Methamphetamine, Methylphenidate, Methamphetamine Methamphetamine, Methylphenidate Ritalinic Acid

Barbiturates Phenobarbital, Secobarbital Benzodiazepines / Alprazolam, Bromazepam Alprazolam, α-Hydroxyalprazolam, Alprazolam, α-Hydroxyalprazolam, Alprazolam, α-Hydroxyalprazolam, Z-Drugs / Bromazepam, 2-Amino-5-chloropyridine Bromazepam, 3-Hydroxybromazepam Bromazepam Thienodiazepines (ACP), 3-Hydroxybromazepam Diazepam, Desmethyldiazepam Chlordiazepoxide, Clobazam, Chlordiazepoxide, Clobazam, Clobazam, Desmethylclobazam, Desmethyclobazam, Clonazepam, Clonazepam, 7-Aminoclonazepam, Clonazepam, 7-Aminoclonazepam, 7-Aminoclonazepam, Demoxepam, Demoxepam, Diazepam, Diazepam, Desmethyldiazepam Diazepam, Desmethyldiazepam, N-Desmethyldiazepam Etizolam

Flunitrazepam, 7-Aminoflunitrazepam, Flunitrazepam, 7-Aminoflunitrazepam, Flunitrazepam, 7-Aminoflunitrazepam, Flunitrazepam, 7-Aminoflunitrazepam, Lorazepam Desmethylflunitrazepam, Flurazepam, N-Desmethlflunitrazepam, Desmethylflunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Flurazepam, N-Desalkylflurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Midazolam, Lorazepam, Lormetazepam, Lormetazepam, Midazolam, Nitraze- α-Hydroxymidazolam, Nitrazepam, Midazolam, 1-Hydroxymidazolam, pam, 7-Aminonitrazepam 7-Aminonitrazepam Nitrazepam, 7-Aminonitrazepam

Oxazepam, Zolpidem Oxazepam, Phenazepam, Prazepam, Oxazepam, Phenazepam, Temazepam, Oxazepam, Phenazepam, Prazepam, Temazepam, Tetrazepam, Triazolam, Tetrazepam, Triazolam, Zaleplon, Temazepam, Tetrazepam, Triazolam, Zaleplon, Zolpidem, Zopiclone Zolpidem, Zopiclone Zolpidem, Zopiclone

Cannabinoids THC, CBD (Cannabidiol), CBD (Cannabidiol), THC, 11-OH-THC, THC-COOH THC, 11-OH-THC, THC-COOH CBN (Cannabinol) THC-COOH

Cathinones Mephedrone, Methedrone, Methylone Mephedrone, Mephedrone, Methedrone, Methylone MDPV (Methylenedioxypyrovalerone)

Cocaine Cocaine, Norcocaine, Benzoylecgonine, Cocaine, Benzoylecgonine, Cocaine, Benzoylecgonine, Cocaine, Benzoylecgonine, Cocaethylene, Ecgonine methyl ester, Cocaethylene, Ecgonine methyl ester Ecgonine methyl ester Cocaethylene, Ecgonine methyl ester Anhydroecgonine methyl ester

Congener Alcohols Acetone, 1-Butanol, 2-Butanol, 2-Butanon, Methanol, 2-Methyl-1- butanol, 3-Methyl-2-butanol, 2-Methyl- 1-Propanol, 1-Propanol, 2-Propanol

GHB GHB (4-Hydroxybutansäure) GHB (4-Hydroxybutansäure) GHB (4-Hydroxybutansäure)

Hallucinogens LSD Ketamine, LSD, Methaqualone, PCP LSD (Phencyclinidine)

Opioids 6-MAM (6-Monoacetylmorphin), 6-MAM (6-Monoacetylmorphine), 6-MAM (6-Monoacetylmorphine), 6-MAM (6-Monoacetylmorphine), Codeine, Dihydrocodeine, Codeine, Acetylcodeine, Codeine, Dihydrocodeine Acetylcodeine, Codeine, Diacetylmorphine (Heroin) Dihydrocodeine Dihydrocodeine

Fentanyl, Morphine Fentanyl, Norfentanyl, Hydrocodone, Fentanyl, Norfentanyl, Morphine, Fentanyl, Norfentanyl, Hydrocodone, Hydromorphone, Morphine, Morphin-3-ß-D-glucuronide, Hydromorphone, Morphine, Dihydromorphine, Ethyl morphine Hydromorphone Dihydromorphine, Ethyl morphine

Oxycodone, Oxymorphone Oxycodone, Oxymorphone, Pholcodine Oxycodone, Oxymorphone, Oxycodone, Oxymorphone, Pholcodine Pregabalin, Propoxyphen Tilidine, Nortilidine, Tramadol, Tapendadol, Tilidine, Nortilidine, Tilidine, Nortilidine, Tramadol, Tapentadol, Tilidine, Nortilidine, Nortramadol Bisnortilidine, Tramadol, o-Desmethyltramadol Tramadol, o-Desmethyltramadol o-Desmethyltramadol

Opioids (Substitu- Buprenorphine, Norbuprenorphine, Buprenorphine, Norbuprenorphine, Buprenorphine, Norbuprenorphine, Buprenorphine, Norbuprenorphine, tion) Methadone, EDDP Methadone, EDDP Methadone, EDDP Methadone, EDDP Piperazines Benzylpiperazine Benzylpiperazine

Order Information REF REF REF REF

Vial à 100 mg: 00HL00VA 40151 40201 40161

Vial à 300 mg: 00HL00XA 10 vials for 2,5 mL 9 vials for 5 mL 10 vials for 2,5 mL

1-mm-cut Lyophilisate Lyophilisate Lyophilisate

40201 Basis-line U: Bisoprolol detected in therapeutic range (ca. 400 µg/L)

All products conform to IVD Directive 98/79/EC + 49 (0)7157 / 5304 - 11

IVD 6 B Certified quality management according to DIN EN ISO 9001:2015 [email protected] DIN EN ISO 13485:2016 :

71144 Steinenbronn GERMANY

Reference Materials Price list, 2020-07-22 (excerpt)

Clinical and Forensic Toxicology Page 1/1

REF Product Unit € REF Product Unit €

1.7 Alcohol VII – Consumption Biomarkers I - Hair (1-mm-cut) 1.11 Drugs of Abuse II – Hair (1-mm-cut)

Authentic Hair Samples Authentic Hair Samples 00H L0 0 VA Medidrug ® Basis-line H-a (neg.) 1 x 100 mg ) 00H L00 VA Medidrug ® Basis-line H-a (neg.) 1 x 100 mg ) 00H L00 XA Medidrug ® Basis-line H-a (neg.) 1 x 300 mg ) 00H L00 XA Medidrug ® Basis-line H-a (neg.) 1 x 300 mg ) ® LOT 15H R0 1 VA Medidrug ALCM 1/11-B H-a 1 x 100 mg ) Spiked Hair Samples LOT 15H R01 XA Medidrug ® ALCM 1/11-B H-a 1 x 300 mg ) LOT 24H L 00 VA Medidrug ® DOA 14 H-d L0 1 x 100 mg ) LOT 15H R0 2 VA Medidrug ® ALCM 1/11-C H-a 1 x 100 mg ) LOT 24H L 01 VA Medidrug ® DOA 14 H-d L1 1 x 100 mg ) LOT 15H R02 XA Medidrug ® ALCM 1/11-C H-a 1 x 300 mg ) LOT 24H L 02 VA Medidrug ® DOA 14 H-d L2 1 x 100 mg ) LOT 15H R03 VA Medidrug ® ALCM 12-A H-a 1 x 100 mg ) LOT 24H L 03 VA Medidrug ® DOA 14 H-d L3 1 x 100 mg ) LOT 15H R03 XA Medidrug ® ALCM 12-A H-a 1 x 300 mg ) LOT 24H L 04 VA Medidrug ® DOA 14 H-d L4 1 x 100 mg ) LOT 15H R04 VA Medidrug ® ALCM 12-B H-a 1 x 100 mg ) LOT 24H L 05 VA Medidrug ® DOA 14 H-d L5 1 x 100 mg ) LOT 15H R04 XA Medidrug ® ALCM 12-B H-a 1 x 300 mg ) LOT 24H L 06 VA Medidrug ® DOA 14 H-d L6 1 x 100 mg ) LOT 15H R10 VA Medidrug ® ALCM 14-A H-a 1 x 100 mg ‰ For details: www.medichem.de/media/files/hi_e.pdf -New- ) LOT 15H R10 XA Medidrug ® ALCM 14-A H-a 1 x 300 mg -New- ) LOT 15H R11 VA Medidrug ® ALCM 14-B H-a 1 x 100 mg 1.13 Blank Matrices – Hair, Serum, Urine and Whole Blood -New- ) LOT 15H R11 XA Medidrug ® ALCM 14-B H-a 1 x 300 mg 00H L00 VA Medidrug ® Basis-line H-a (neg.) 1 x 100 mg -New- ) ) ® Incorporated / Soaked Hair Samples 00H L00 XA Medidrug Basis-line H-a (neg.) 1 x 300 mg ) LOT 15H R06 UA Medidrug ® FAEE 12-C H-i 1 x 50 mg ) 40151 Medidrug ® Basis-line S (neg.) 10 x 2.5 mL 105,00 LOT 15H R07 UA Medidrug ® FAEE 12-D H-i 1 x 50 mg ) 40161 Medidrug ® Basis-line VB (neg.) 10 x 2.5 mL 125,00 LOT 15H R08 UA Medidrug ® FAEE 12-E H-i 1 x 50 mg ) 40201 Medidrug ® Basis-line U (neg.) 9 x 5 mL 70,00 LOT 15H R09 UA Medidrug ® FAEE 12-F H-i 1 x 50 mg ) Spiked Hair Samples

15H L00 VA Medidrug ® EtG H-d 000

15H L00 V F Medidrug ® EtG H-d 000

15H L 02 VA Medidrug ® EtG H-d 004 4 pg/mg 1 x 100 mg 45,00

15H L02 V F Medidrug ® EtG H-d 004 4 pg/mg 10 x 100 mg 400,00

Please note our new item numbers: -NEW- 15H L 03 VA Medidrug ® EtG H-d 005 5 pg/mg 1 x 100 mg 45,00

-NEW- 15H L03 V F Medidrug ® EtG H-d 005 5 pg/mg 10 x 100 mg 400,00

15H L04 VA Medidrug ® EtG H-d 007 7 pg/mg 1 x 100 mg 45,00

15H L04 V F Medidrug ® EtG H-d 007 7 pg/mg 10 x 100 mg 400,00

15H L06 VA Medidrug ® EtG H-d 020 20 pg/mg 1 x 100 mg 45,00

15H L06 V F Medidrug ® EtG H-d 020 20 pg/mg 10 x 100 mg 400,00

15H L07 VA Medidrug ® EtG H-d 025 25 pg/mg 1 x 100 mg 45,00

15H L07 V F Medidrug ® EtG H-d 025 25 pg/mg 10 x 100 mg 400,00

15H L08 VA Medidrug ® EtG H-d 030 30 pg/mg 1 x 100 mg 45,00

15H L08 V F Medidrug ® EtG H-d 030 30 pg/mg 10 x 100 mg 400,00

15H L09 VA Medidrug ® EtG H-d 040 40 pg/mg 1 x 100 mg 45,00

15H L09 V F Medidrug ® EtG H-d 040 40 pg/mg 10 x 100 mg 400,00

15H L10 VA Medidrug ® EtG H-d 050 50 pg/mg 1 x 100 mg 45,00

15H L10 V F Medidrug ® EtG H-d 050 50 pg/mg 10 x 100 mg 400,00

15H L 11 VA Medidrug ® EtG H-d 100 100 pg/mg 1 x 100 mg 45,00

15H L11 V F Medidrug ® EtG H-d 100 100 pg/mg 10 x 100 mg 400,00

15H L 12 VA Medidrug ® EtG H-d 200 200 pg/mg 1 x 100 mg 45,00

15H L12 V F Medidrug ® EtG H-d 200 200 pg/mg 10 x 100 mg 400,00

‡ Product cancelled € Prices in Euro exclusive of VAT and/or taxes

► ) Product / price available on request Product available only as long as still on stock – will be cancelled

LOT Product has been produced especially for an external quality control (proficiency testing). The catalogue code REF refers to a singular lot (batch). After expiry of the validity or being sold out it is no longer available. If possible new lots with similar compositions of components will be offered with a different catalogue code.