ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

Volume 37, Number 5, May 2017

Contents Reviews

The Kynurenine Pathway: A Primary Resistance Mechanism in Patients with Glioblastoma. P.P. SORDILLO, L.A. SORDILLO, L. HELSON (Quakertown, PA; New York, NY, USA) ...... 2159

Implications of Different Cancer Stem Cell Phenotypes in Breast Cancer. A.D.C. PAULA, C. LOPES (Porto, Portugal) ...... 2173

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas. D. MORIS, C. DAMASKOS, E. SPARTALIS, A. PAPALAMPROS, S. VERNADAKIS, D. DIMITROULIS, J. GRINIATSOS, E. FELEKOURAS, N. NIKITEAS (Columbus, OH, USA; Athens, Greece; Riyadh, Kingdom of Saudi Arabia) ...... 2185 Experimental Studies

Delayed Progression of Lung Metastases Following Delivery of a Prodrug-activating Enzyme. L. DORE- SAVARD, Z. CHEN, P.T. WINNARD JR., B. KRISHNAMACHARY,V. RAMAN, M.E. BLACK, Z.M. BHUJWALLA (Baltimore, MD; Pullman, WA, USA) ...... 2195

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer. J. HAGEMANN, C. JACOBI, M. HAHN, V. SCHMID, C. WELZ, S. SCHWENK-ZIEGER, R. STAUBER, P. BAUMEISTER, S. BECKER (Mainz; Munich; Göttingen, Germany) ...... 2201

Moesin Expression is Associated with Glioblastoma Cell Proliferation and Invasion. Q. WANG, X. LU, S. ZHAO, M. PANG, X. WU, H. WU, R.M. HOFFMAN, Z. YANG, Y. ZHANG (Wuxi; Nanjing, PR China; San Diego, CA, USA) ...... 2211 Contents continued on the back cover Contents continued

Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma. I. PANAGOPOULOS, L. GORUNOVA, I. LOBMAIER, H.K. ANDERSEN, B. BJERKEHAGEN, S. HEIM (Oslo, Norway) ...... 2219

Amphiregulin as a Novel Resistance Factor for Amrubicin in Lung Cancer Cells. S. TOKUNAGA, T. , K. KOBAYASHI, M. KATSURADA, K. NAKATA, M. YAMAMOTO, M. TACHIHARA, H. KAMIRYO, H. YOKOZAKI, Y. NISHIMURA (, ) ...... 2225

Case Report: A Low-grade Uterine Leiomyosarcoma Showing Multiple Genetic Aberrations Including a Bi- allelic Loss of the Retinoblastoma Gene Locus, as well as Germ-line Uniparental Disomy for Part of the Long Arm of Chromosome 22. C. HOLZMANN, D. KOCZAN, T. LOENING, B. ROMMEL, J. BULLERDIEK (Rostock; Hamburg; Bremen, Germany) ...... 2233

Detection and Quantification of Nuclear Morphology Changes in Apoptotic Cells by Fluorescence Microscopy and Subsequent Analysis of Visualized Fluorescent Signals. R. MANDELKOW, D. GÜMBEL, H. AHREND, A. KAUL, U. ZIMMERMANN, M. BURCHARDT, M.B. STOPE (Greifswald, Germany) ...... 2239

OPN-a Splicing Variant Expression in Non-small Cell Lung Cancer and its Effects on the Bone Metastatic Abilities of Lung Cancer Cells In Vitro. C. HAO, Y. CUI, M. HU, X. ZHI, L. ZHANG, W. LI, W. WU, S. CHENG, W.G. JIANG (Beijing, PR China; Cardiff, UK) ...... 2245

Up-regulation of SLC9A9 Promotes Cancer Progression and Is Involved in Poor Prognosis in Colorectal Cancer. M. UEDA, T. IGUCHI, T. MASUDA, H. KOMATSU, S. NAMBARA, S. SAKIMURA, H. HIRATA, Y. UCHI, H. EGUCHI, S. ITO, K. SUGIMACHI, T. MIZUSHIMA, Y. DOKI, M. MORI, K. MIMORI (Beppu; ; , Japan) ...... 2255

Are Corrupted Non-dysplastic Colonic Crypts the First Histological Event in Experimental Colonic Carcinogenesis? C.A. RUBIO (Stockholm, Sweden) ...... 2265

PD-L1 Expression in Patients with Non-small Cell Lung Cancer. K. MASAGO, S. FUJITA, A. HATA, C. OKUDA, R. KAJI, N. KATAKAMI, Y. HIRATA (Kobe, Japan) ...... 2269

Genome-wide Expression Profiling (with Focus on the Galectin Network) in Tumor, Transition Zone and Normal Tissue of Head and Neck Cancer: Marked Differences Between Individual Patients and the Site of Specimen Origin. V. ZIVICOVA, P. BROZ, Z. FIK, A. MIFKOVA, J. PLZAK, Z. CADA, H. KALTNER, J. FIALOVA KUCEROVA, H.-J. GABIUS, K. SMETANA JR. (Prague; Vestec, Czech Republic; Munich, Germany) ...... 2275

Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma. L.C. SCHMEEL, F.C. SCHMEEL, Y. KIM, S. BLAUM-FEDER, I.G.H. SCHMIDT-WOLF (Bonn, Germany) ...... 2289

Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells. X.-P. JIANG, R.L. ELLIOTT (Baton Rouge, LA, USA) ...... 2297

The Contribution of Excision Repair Cross-complementing Group 1 Genotypes to Colorectal Cancer Susceptibility in Taiwan. T.-C. YUEH, A.-K. CHOU, C.-L. GONG, C.-K. FU, J.-S. PEI, M.-H. WU, C.-W. TSAI, W.-S. CHANG, C.-L. HSIAO, S.-T. YEN, H.-T. LI, D.-T. BAU (Taichung; Taoyuan, Taiwan, ROC) ..... 2307

Effects of Nonsteroidal Anti-inflammatory Drugs on the Self-renewal Capacity of Blast Progenitors in Hematological Malignancies. Z. YI, Z. YAN, K. MIYAHARA, M. SHIMADA, K.-I. TANAKA, H. HAYASHI, N. IHARA, I. MUROHASHI (, Japan) ...... 2315

Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer. T.-M. STRATI, V. KOTOULA, I. KOSTOPOULOS, K. MANOUSOU, C. PAPADIMITRIOU, G. LAZARIDIS, S. LAKIS, G. PENTHEROUDAKIS, D. PECTASIDES, E. PAZARLI, C. CHRISTODOULOU, E. RAZIS, K. PAVLAKIS, C. MAGKOU, S. CHRISAFI, G. ARAVANTINOS, D. BAFALOUKOS, P. PAPAKOSTAS, H. GOGAS, K.T. KALOGERAS, G. FOUNTZILAS (Thessaloniki; Athens; Ioannina; Piraeus, Greece) ...... 2323 Contents continued on the preceding page Contents continued

Phospho-STAT5B Expression Is a Prognostic Marker for Merkel Cell Carcinoma. T. FUJIMURA, S. FURUDATE, Y. KAMBAYAHSI, A. KAKIZAKI, Y. YAMAMOTO, H. OKUHIRA, N. FUJIMOTO, S. AIBA (; ; Shiga, Japan) ...... 2335

Heterogeneous Cell Types in Single-cell-derived Clones of MCF7 and MDA-MB-231 Cells. G.N. KHAN, E.J. KIM, T.S. SHIN, S.H. LEE (Seoul, Republic of Korea) ...... 2343

Azacytidine-induced Chemosensitivity to Doxorubicin in Human Breast Cancer MCF7 Cells. G.N. KHAN, E.J. KIM,T.S. SHIN, S.H. LEE (Seoul, Republic of Korea) ...... 2355

Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. K. SATO, T. MASUDA, Q. HU, T. TOBO, S. KIDOGAMI, Y. OGAWA, T. SAITO, S. NAMBARA, H. KOMATSU, H. HIRATA, S. SAKIMURA, R. UCHI, N. HAYASHI, T. IGUCHI, H. EGUCHI, S. ITO, T. NAKAGAWA, K. MIMORI (Oita; Fukuoka, Japan) ...... 2365

Inhibition of Importin β1 With a 2-Aminothiazole Derivative Resulted in G 2/M Cell-cycle Arrest and Apoptosis. S. HA, J. CHOI, N.Y. MIN, K.-H. LEE, S.W. HAM (Seoul, Republic of Korea) ...... 2373 LA1 Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras Lung Cancer Mice. A.Y. LEE, S. KIM, S. LEE, H.-L. JIANG, S.-B. KIM, S.-H. HONG, M.-H. CHO (Seoul; Daegu; Suwon; Daehwa-myeon, Republic of Korea; Nanjing, PR China) ...... 2381

Tumor Protein 53 Gene Mutations Without 17p13 Deletion Have No Significant Clinical Implications in Chronic Lymphocytic Leukemia. Detection of a New Mutation. P.T. DIAMANTOPOULOS, S. SAMARA, P. KOLLIA, N. GIANNAKOPOULOU, M. SOFOTASIOU, F. KALALA, E. KODANDREOPOULOU, P. ZERVAKIS, T. VASSILAKOPOULOS, M. SIAKANTARIS, M. MANTZOURANI, M. ANGELOPOULOU, M.-C. KYRTSHONIS, P. KORKOLOPOULOU, E. PATSOURIS, N.-A. VINIOU (Athens, Greece) ...... 2387

Fibronectin and Hepatocyte Growth Factor Produced by Lung Fibroblasts Augment Migration and Invasion of Malignant Pleural Mesothelioma Cells. N. KANAJI, N. KITA, N. KADOWAKI, S. BANDOH (Kagawa, Japan) ...... 2393

Expression of hsa-miR-9 and MYC Copy Number Variation in Hereditary Diffuse Gastric Cancer. K.C.D.S. OLIVEIRA, A.B. BONA, F.J. DA SILVA, T.M. PINHEIRO, D.D.F.A. ALCANTARA, L.M. LAMARAO, C.A. MOREIRA-NUNES, P.P. ASSUMPCAO, R.R. BURBANO, D.Q. CALCAGNO (Belem; Fortaleza, Brazil) .... 2401

Expression of Cell Cycle-related Proteins p16, p27 and Ki-67 Proliferating Marker in Laryngeal Squamous Cell Carcinomas and in Laryngeal Papillomas. U. CIESIELSKA, T. ZATONSKI, K. NOWINSKA, K. RATAJCZAK- WIELGOMAS, J. GRZEGRZOLKA, A. PIOTROWSKA, M. OLBROMSKI, B. PULA, M. PODHORSKA- OKOLOW, P. DZIEGIEL (Wroclaw, Poland) ...... 2407

Contribution of Double-strand Break Repair Gene Nijmegen Breakage Syndrome 1 Genotypes, Gender Difference and Smoking Status to Taiwanese Lung Cancer. C.-L. CHUANG, C.-H. WANG, C.-H. HSU, C.-L. HSIAO, G.-L. CHEN, S.-T. YEN, H.-T. LI, W.-S. CHANG, C.-W. TSAI, S.-C. WANG, D.-T. BAU (Taichung; Taipei, Taiwan, ROC) ...... 2417

Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, Τhus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. N. GOMBODORJ, T. YOKOBORI, S. YOSHIYAMA, R. KAWABATA-IWAKAWA, S. ROKUDAI, I. HORIKOSHI, M. NISHIYAMA, T. NAKANO (Gunma, Japan; Ulaanbaatar, Mongolia) ...... 2425

Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. K. NA, J.-Y. SUNG, H.-S. KIM (Seoul, Republic of Korea) ...... 2437 Contents continued on the preceding page Contents continued

Clinical Studies

Cardiac Imaging Methods for Chemotherapy-related Cardiotoxicity Screening and Related Radiation Exposure: Current Practice and Trends. B.C. KOLLA, S.S. ROY, S. DUVAL, D. WEISDORF, U. VALETI, A. BLAES (Minneapolis, MN, USA) ...... 2445

Cyr61 Expression Pattern and Association with Clinicopathological Factors in Patients with Cervical Cancer. S. MAYER, B. GABRIEL, T. ERBES, S. TIMME-BRONSERT, M. JÄGER, G. RÜCKER, F. KUF, J. BOUDA, A. BARTAKOVA, A.Z. HAUSEN, E. STICKELER, G. GITSCH, M. HIRSCHFELD (Freiburg; Wiesbaden; Aachen; Goettingen, Germany; Plzen, Czech Republic; Maastricht, the Netherlands) ...... 2451

EAGLES Study: First-line Bevacizumab in Combination with Chemotherapy in Elderly Patients with Advanced, Metastatic, Nonsquamous Non-small Cell Lung Cancer. F. DE MARINIS, P. BIDOLI, A. LUCIANI, D. AMOROSO, G. TONINI, A. BERTOLINI, A.A. BRANDES, M.R. MIGLIORINO, A. FAVARETTO, C. GRIDELLI (Milan; Monza; Camaiore; Rome; Sondrio; Bologna; Treviso; Avellino, Italy) ...... 2457

Combined Analyses of hENT1, TS, and DPD Predict Outcomes of Borderline-resectable Pancreatic Cancer. Y. YABUSHITA, R. MORI, K. TANIGUCHI, R. , T. , K. SAKAMAKI, K. KUBOTA, I. ENDO (, Japan) ...... 2465

Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. K. DRESSEN, N. HERMANN, S. MANEKELLER, G. WALGENBACH-BRUENAGEL, F.A. SCHILDBERG, K. HETTWER, S. UHLIG, J.C. KALFF, G. HARTMANN, S. HOLDENRIEDER (Bonn; Dresden, Germany) ...... 2477

Therapeutic Pelvic Lymph Node Dissection in the Second Gestational Trimester: A Case Report and Literature Review. M.Z. MUALLEM, W. HENRICH, T. BRAUN, J. SEHOULI, L. KRETZSCHMAR (Berlin, Germany) ...... 2487

Impact of Therapy Sequence with Alkylating Agents and MGMT Status in Patients with Advanced Neuroendocrine Tumors. S. KRUG, M. BOCH, P. REXIN, T.M. GRESS, P. MICHL, A. RINKE (Halle; Marburg, Germany) ...... 2491

Customized Adjuvant Chemotherapy Based on Biomarker Examination May Improve Survival of Patients Completely Resected for Non-small-cell Lung Cancer. D. LIU, N. NAKASHIMA, J. NAKANO, S. TARUMI, N. MATSUURA, T. NAKANO, K. NII, Y. TOKUNAGA, T. GO, H. YOKOMISE (Takamatsu, Japan) ...... 2501

Pleomorphic Rhabdomyosarcoma of the Uterus – Case Report and a Systematic Review of the Literature. S. ALAVI, L. ECKES, R. KRATSCHELL, E.T. TAUBE, F. ROSSECK, G. WIENERS, J. SEHOULI (Berlin, Germany) ...... 2509

Comparison of Outcomes with Hand-sewn Versus Stapler Closure of Pancreatic Stump in Distal Pancreatectomy. Y. FUTAGAWA, Y. TAKANO, K. FURUKAWA, M. KANEHIRA, S. ONDA, T. SAKAMOTO, T. GOCHO, H. SHIBA, K. YANAGA (, Japan) ...... 2515

Surgical Resection of Malignancies Invading Inferior Vena Cava Level I and II. Issues Still Need to Be Discussed. E. VICENTE, Y. QUIJANO, B. IELPO, H. DURAN, E. DIAZ, I. FABRA, L. MALAVÉ, V. FERRI, A. FERRONETTI, R. CARUSO (Madrid, Spain) ...... 2523

Prediction of Relapse After Therapy Withdrawal in Women with Endometrial Hyperplasia: A Long-term Follow- up Study. E.T. SLETTEN, M. ARNES, L.M. LYSA, B.T. MOE, B. STRAUME, A. ORBO (Tromso, Norway) 2529

Validation of a Score Developed to Estimate the 6-month Survival of Patients Treated with Palliative Local Radiotherapy for Advanced Lung Cancer. S. JANSSEN, B. VAN OORSCHOT, L. KÄSMANN, S.E. SCHILD, D. RADES (Lübeck; Würzburg, Germany; Scottsdale, AZ, USA) ...... 2537 Contents continued on the preceding page Contents continued

The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma. T. MIYATA, T. OYAMA, T. YOSHIMATSU, H. HIGA, D. KAWANO, A. SEKIMURA, N. YAMASHITA, T. SO, A. GOTOH (Nishinomiya; Fukuoka; Kitakyusyu; Takeo, Japan) ...... 2541

Index of Estimated Benefit from Lateral Lymph Node Dissection for Middle and Lower Rectal Cancer. M. NUMATA, T. , Y. KINUGASA, A. SHIOMI, H. KAGAWA, Y. YAMAKAWA, A. FURUTANI, S. MANABE, Y. YAMAOKA (, Japan) ...... 2549

Clinicopathological Characteristics of Mitotically-active Cellular Fibroma of the Ovary: A Single-institutional Experience. J.-Y. KIM, K. NA, H.-S. KIM (Seoul, Republic of Korea) ...... 2557

Clinicopathological Characteristics of Primary Ovarian Adenomyoma: A Single-institutional Experience. K. NA, S.Y. PARK, H.-S. KIM (Seoul, Republic of Korea) ...... 2565

Salvage Radiotherapy for Solitary Metachronous Bone Metastasis in Patients with Breast Cancer. M. MIYATA, T. OHGURI, K. YAHARA, S. YAMAGUCHI, H. IMADA, Y. KOROGI (, Japan) ...... 2575

Primary Non-Hodgkin’s Lymphoma of the Gallbladder: Α Population-based Analysis. A. AYUB, S. REHMANI, A.M. AL-AYOUBI, E. LEWIS, N. SANTANA-RODRÍGUEZ, W. RAAD, F. BHORA, G. KIM (New York, NY, USA) ...... 2581

DDR2 Expression Is Associated with a High Frequency of Peritoneal Dissemination and Poor Prognosis in Colorectal Cancer. S. SASAKI, M. UEDA, T. IGUCHI, M. KANEKO, H. NAKAYAMA, T. WATANABE, A. SAKAMOTO, K. MIMORI (Tokyo; Beppu, Japan) ...... 2587

Prescription Patterns of Sorafenib and Outcomes of Patients with Advanced Hepatocellular Carcinoma: A National Population Study. L.-C. LU, P.-J. CHEN, Y.-C. YEH, C.-H. HSU, H.-M. CHEN, M.-S. LAI, Y.-Y. SHAO, A.-L. CHENG (Taipei, Taiwan, ROC) ...... 2593

Multiple Visceral Resections for Synchronous Left and Transverse Colon Adenocarcinoma with Gastrocolic- cutaneous Fistula – Case Report and Literature Review. N. BACALBASA, C. STOICA, I. BALESCU (Bucharest, Romania) ...... 2601

Infracolic Approach to the Superior Mesenteric Vessels for a Large Pancreatic Tumor with Right Colon Invasion – A Case Report and Literature Review. N. BACALBASA, I. BALESCU (Bucharest, Romania) ...... 2609

Solitary Splenic Metastasis Αfter Surgically-treated Cervical Cancer – A Case Report and Literature Review. N. BACALBASA, I. BALESCU, M. MARCU, D.N. ORESCU, A.F. ANCA (Bucharest, Romania) ...... 2615

Surgical Treatment and Outcome of Patients with De Novo Lung Cancer After Liver Transplantation. F. SHOJI, G. TOYOKAWA, N. HARADA, S. ITOH, N. HARIMOTO, T. IKEGAMI, T. OKAMOTO, Y. SOEJIMA, T. YOSHIZUMI, Y. MAEHARA (Fukuoka, Japan) ...... 2619

Predictive Independent Factors for Extrahepatic Metastasis of Hepatocellular Carcinoma Following Curative Hepatectomy. M. HASHIMOTO, T. KOBAYASHI, K. ISHIYAMA, K. IDE, M. OHIRA, H. TAHARA, S. KURODA, M. HAMAOKA, H. IWAKO, S. OKIMOTO, N. HONMYO, H. OHDAN (, Japan) ...... 2625

Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes. S. ANGELINI, A. BOTTICELLI, C.E. ONESTI, R. GIUSTI, V. SINI, V. DURANTE, L. STRIGARI, G. GENTILE, B. CERBELLI, P. PELLEGRINI, V. SGROI, M. OCCHIPINTI, F.R. DI PIETRO, A. ROSSI, M. SIMMACO, F. MAZZUCA, P. MARCHETTI (Rome, Italy) ...... 2633

Moderate/severe Depression (MADRS) Can Affect the Quality of Life and Outcome Among Patients Admitted to Breast Cancer Diagnosis Unit. M. ESKELINEN, T. SELANDER, P. OLLONEN, R. KORHONEN (Kuopio, Finland) ...... 2641 Contents continued on the preceding page Contents continued

Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. D.O. IRABOR, O.A. OLUWASOLA, O.J. OGUNBIYI, O.G. OGUN, C.A. OKOLO, M. MELAS, S.B. GRUBER, C. SHI, L. RASKIN (Ibadan, Nigeria; Los Angeles, CA; Nashville, TN, USA) ...... 2649

Prediction of Prognosis for Patients with Diffuse Large B-Cell Lymphoma Refractory to or in First Relapse After Initial R-CHOP Therapy: A Single-Institution Study. M. YAMAMOTO, K. WATANABE, T. FUKUDA, O. MIURA (Tokyo, Japan) ...... 2655

Efficacy and Safety Analysis of Oxaliplatin-based Chemotherapy for Advanced Gastric Cancer. K. INADOMI, H. KUSABA, Y. MATSUSHITA, R. TANAKA, K. MITSUGI, K. ARIMIZU, G. HIRANO, A. MAKIYAMA, H. OHMURA, K. UCHINO, F. HANAMURA, Y. SHIBATA, M. KUWAYAMA, T. ESAKI, K. TAKAYOSHI, S. ARITA, H. ARIYAMA, K. AKASHI, E. BABA (Fukuoka; Kitakyushu, Japan) ...... 2663

Clinical Benefits of Lymph Node Dissection in Intrahepatic Cholangiocarcinoma: A Retrospective Single- institution Study. T. MIYATA, Y.-I. YAMASHITA, T. YAMAO, N. UMEZAKI, M. TSUKAMOTO, Y. KITANO, K. YAMAMURA, K. ARIMA, T. KAIDA, S. NAKAGAWA, K. IMAI, D. HASHIMOTO, A. CHIKAMOTO, T. ISHIKO, H. BABA (Kumamoto, Japan) ...... 2673

Clinical Significance of 5-Fluorouracil Chemosensitivity Testing in Patients with Colorectal Cancer. W.B. JI, J.W. UM, J.S. RYU, K.D. HONG, J.S. KIM, B.W. MIN, S.Y. JOUNG, J.H. LEE, Y.S. KIM (Gyeonggi-do; Seoul, Republic of Korea) ...... 2679

Neoadjuvant Chemotherapy with Capecitabine, Oxaliplatin and Bevacizumab Followed by Concomitant Chemoradiation and Surgical Resection in Locally Advanced Rectal Cancer with High Risk of Recurrence – A Phase II Study. W. EISTERER, G. PIRINGER, A. DE VRIES, D. ÖFNER, R. GREIL, J. TSCHMELITSCH, E. SAMONIGG, L. SÖLKNER, M. GNANT, J. THALER (Klagenfurt; Wels; Feldkirch; Innsbruck; Salzburg; Sankt Veit an der Glan; Graz; Vienna, Austria) ...... 2683

Simplified Comorbidity Score and Eastern Cooperative Oncology Group Performance Score Predicts Survival in Patients Receiving Organ-preserving Treatment for Bladder Cancer. L. MANIG, L. KÄSMANN, S. JANSSEN, S.E. SCHILD, D. RADES (Lübeck, Germany; Scottsdale, AZ, USA) ...... 2693

Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management. J. PRESL, P. OVESNA, Z. NOVOTNY, P. VLASAK, J. BOUDA, J. KOSTUN, O. TOPOLCAN, R. KUCERA, M. BEDNARIKOVA, V. WEINBERGER (Pilsen; Brno, Czech Republic) ...... 2697

Phase I Study of Definitive Radio-chemotherapy with Cisplatin, 5-Fluorouracil and Cetuximab for Unresectable Locally Advanced Esophageal Cancer. D. RADES, A. MADERER, A. PANZNER, P. HUNOLD, V. SIVANATHAN, H. SCHMIDBERGER, M.H. MOEHLER (Lübeck; Mainz, Germany) ...... 2703

Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer. K. JINGU, Y. MATSUO, H. ONISHI, T. YAMAMOTO, M. AOKI, Y. MURAKAMI, H. YAMASHITA, H. KAKUHARA, K. NEMOTO, T. SAKAYAUCHI, M. OKAMOTO, Y. NIIBE, Y. NAGATA, K. OGAWA (Sendai; ; Yamanashi; Hirosaki; Hiroshima; Tokyo; ; Yamagata; Furukawa; ; , Japan) ...... 2709

Initial Experience with Nab-Paclitaxel for Patients with Advanced Gastric Cancer: Safety and Efficacy. Y. , I. FUJITA, D. KAKINUMA, H. ARAI, K. MATSUNO, T. SHIMODA, K. KO, S. KATO, E. UCHIDA (Tokyo, Japan) ...... 2715

EGFR T790M Detection in Circulating Tumor DNA from Non-small Cell Lung Cancer Patients Using the PNA- LNA Clamp Method. H. YOSHIDA, Y.H. KIM, H. OZASA, H. NAGAI, Y. SAKAMORI, T. TSUJI, T. NOMIZO, T. FUNAZO, Y. YASUDA, T. HIRAI (Kyoto, Japan) ...... 2721 Contents continued on the preceding page Contents continued

Relationship Between Circulating Tumor Cells and Annexin A2 in Early Breast Cancer Patients. B. BYSTRICKY, Z. CIERNA, G. SIEBEROVA, P. JANEGA, M. KARABA, G. MINARIK, J. BENCA, T. SEDLACKOVA, S. JURISOVA, P. GRONESOVA, D. PINDAK, J. MACUCH, J. MARDIAK, M. MEGO (Bratislava; Trencin, Slovakia) ...... 2727

Significance of the Preoperative CONUT Score in Predicting Postoperative Disease-free and Overall Survival in Patients with Lung Adenocarcinoma with Obstructive Lung Disease. T. AKAMINE, G. TOYOKAWA, T. MATSUBARA, Y. KOZUMA, N. HARATAKE, S. TAKAMORI, M. KATSURA, K. TAKADA, F. SHOJI, T. OKAMOTO, Y. MAEHARA (Fukuoka, Japan) ...... 2735

Intraoperative Local Ablative Therapies Combined with Surgery for the Treatment of Bilobar Colorectal Liver Metastases. M. BARABINO, A. GATTI, R. SANTAMBROGIO, M. POLIZZI, C. LUIGIANO, E. OPOCHER (Milan, Italy) ...... 2743

Erratum ...... 2751