Preventiverx Drug List: Expanded Plan (National Drug List)

Total Page:16

File Type:pdf, Size:1020Kb

Preventiverx Drug List: Expanded Plan (National Drug List) PreventiveRx Drug List: Expanded Plan (National Drug List) PreventiveRxSM covers drugs that may keep you healthy because they may prevent illness and other health conditions. You can get the products on this list at low or no cost to you, depending on your benefit. This list includes only prescription products. Brand-name drugs are listed with a first capital letter. Nonbrand drugs (generics) are in lowercase letters. Brand-name drugs that have a generic equivalent available are not covered under this PreventiveRx benefit. Not all drugs on this list may be covered by your plan. Some drugs, such as those used for cosmetic purposes, may be excluded from your benefits. Please refer to your Certificate or Evidence of Coverage for coverage limitations and exclusions. Antibiotics clarithromycin Loteprednol Etabonate- Rifaximin decadron elx, tab Tobramycin Acetic Acid-Oxyquinoline Clindamycin HCL Silver Dexabliss Vaginal mafenide acetate Clindamycin Palmitate Sulfacetamide Sodium dexamethasone elx, sol, tab Aminosalicylic Acid Hydrochloride Methenamine Hippurate (acne) Dexamethasone Intensol amoxicillin Clindamycin Phosphate methenamine mandelate Sulfadiazine (one dose) dexpak amoxicillin & pot clavulanate metronidazole vaginal sulfamethoxazole/ Clindamycin trimethoprim Dxevo Ampicillin Phosphate Vaginal minocycline HCL sulfamethoxazole- Elixophyllin ampicillin trihydrate cycloserine Moxifloxacin HCL trimethoprim Flovent Diskus Azithromycin dapsone Mupirocin Sulfanilamide Vaginal Flovent HFA Aztreonam Lysine dicloxacillin sodium Mupirocin Calcium (topical) Tedizolid Phosphate fluticasone/salmeterol Bacitracin-Polymyxin- Doxycycline (monohydrate) neomycin sulfate Telithromycin Neomycin Hc fluticasone/salmeterol Doxycycline (rosacea) Neomycin Sulfate- Tobramycin bacitracin-poly-neomycin-hc Fluocinolone Acetonide hydrocortisone tab Doxycycline Calcium Tobramycin-Dexamethasone Bedaquiline Fumarate Neomycin-Colistin-Hc- ipratropium sol Doxycycline Hyclate Thonzonium Trimethoprim cefaclor ipratropium/albuterol sol erythromycin base Neomycin-Fluocinolone Trimethoprim HCL Cefaclor Monohydrate & Emollient levalbuterol HFA Erythromycin Base (coated) vancomycin HCL cefadroxil Neomycin-Polymy-Dexameth levalbuterol neb erythromycin ethylsuccinate metaproterenol syp cefdinir Neomycin-Polymyxin-Hc Asthma erythromycin stearate methylprednisolone Cefditoren Pivoxil neomycin-polymyxin-hc Advair HFA ethambutol HCL (ophth) montelukast chw, gran, tab cefixime albuterol HFA Ethionamide neomycin-polymyxin-hc Perforomist cefpodoxime proxetil (otic) albuterol neb, syp, tab, Fidaxomicin ER tab prednisolone ODT cefprozil nitrofurantoin Fosfomycin Tromethamine Arcapta Neohaler prednisolone sol Cefuroxime Axetil nitrofurantoin macrocrystal Gemifloxacin Mesylate Arnuity Ellipta Prednisone Intensol cephalexin nitrofurantoin monohyd gentamicin sulfate (topical) Ciprofloxacin macro Atrovent HFA prednisone pak, sol, tab Gentamicin-Prednisolone ofloxacin Breo Ellipta Ciprofloxacin HCL Acetate ProAir Digihaler penicillin V potassium Brovana ciprofloxacin-ciprofloxacin isoniazid ProAir HFA HCL pyrazinamide budesonide susp Isoniazid & Rifampin ProAir RespiClick Ciprofloxacin- Retapamulin budesonide/formoterol Dexamethasone Isoniazid-Rifampin Proventil HFA with Pyrazinamide Rifabutin Combivent Respimat Ciprofloxacin-Fluocinolone Serevent Diskus Acetonide levofloxacin Rifampin cortisone acetate Spiriva Respimat Ciprofloxacin- Linezolid Rifapentine cromolyn sodium neb terbutaline Hydrocortisone 40775CAMENABC Rev. 10/20 PreventiveRx Drug List: Expanded Plan (National Drug List) Theo-24 peg 3350/electrolytes Janumet probenecid Diuril theophylline sol, tab peg-prep kit Janumet XR probenecid/colchicine doxazosin mesylate Ventolin HFA Plenvu Januvia Zurampic enalapril maleate wixela inhub Prepopik Jardiance enalapril/HCTZ Heart health and Xolair Suprep Jentadueto XR high blood pressure Epaned zafirlukast TriLyte Korlym acebutolol HCL eplerenone Lantus acetazolamide eprosartan Birth control Breast cancer Levemir afeditab CR felodipine ER All generic versions anastrozole are included. metformin HCL aliskiren fosinopril sodium exemestane Annovera metformin HCL ER amiloride HCL fosinopril/HCTZ letrozole Balcoltra miglitol amiloride/HCTZ furosemide Soltamox Falessa Kit nateglinide amlodipine besylate guanfacine HCL tamoxifen citrate Lo Loestrin 1-10-10 Ozempic amlodipine/benazepril hydralazine HCL toremifene citrate Natazia pioglitazone amlodipine/valsartan hydrochlorothiazide repaglinide indapamide Slynd Diabetes atenolol Soliqua irbesartan Taytulla Diabetic supplies — atenolol/chlorthalidone glucometers/test strips Symlin irbesartan/HCTZ Twirla (Roche and Lifescan benazepril HCL products only), lancets, Synjardy benazepril HCL/HCTZ isosorbide dinitrate control solutions, pen Blood clots needles, insulin syringes. Synjardy XR betaxolol HCL isosorbide dinitrate ER Bevyxxa These products require a prescription to be covered tolazamide bisoprolol fumarate isosorbide mononitrate Brilinta by this plan. tolbutamide bisoprolol fumarate/HCTZ isosorbide mononitrate ER Eliquis acarbose Toujeo bumetanide isradipine enoxaparin Avandia Trulicity Bystolic Kapspargo Sprinkle fondaparinux chlorpropamide Victoza Byvalson Katerzia Fragmin Cycloset Xigduo XR captopril labetalol HCL heparin Farxiga Xultophy captopril/HCTZ lisinopril Pradaxa glimepiride Cardizem LA 120 mg lisinopril/HCTZ Savaysa glipizide Flu cartia XT losartan warfarin glipizide ER/XL oseltamivir carvedilol losartan/HCTZ Xarelto glipizide with metformin HCL Relenza chlorothiazide methazolamide glyburide Xofluza chlorthalidone methyclothiazide Bowel prep glyburide with methyldopa (laxatives) metformin HCL Gout clonidine HCL methyldopa/HCTZ Clenpiq glyburide, micronized allopurinol Corzide metolazone gavilyte Humalog colchicine tab digitek metoprolol succinate ER GoLYTELY packet Humulin Duzallo digoxin metoprolol tartrate MoviPrep Insulin Lispro febuxostat dilt XR metoprolol/HCTZ OsmoPrep Insulin Lispro Protamine Gloperba diltiazem HCL PreventiveRx Drug List: Expanded Plan (National Drug List) minitran tiadylt Malaria Angeliq Stopping smoking minoxidil timolol maleate Arakoda calcitonin spr bupropion HCL SR (generic Zyban only) moexipril HCL torsemide atovaquone/proguanil Climara Pro Chantix moexipril/HCTZ trandolapril chloroquine CombiPatch Nicotrol Inhaler nadolol/ trandolapril/verapamil hydroxychloroquine Dotti bendroflumethiazide Nicotrol NS triamterene mefloquine HCL Duavee nicardipine HCL valsartan primaquine estradiol tab, patch Stroke nifedipine valsartan/HCTZ pyrimethamine estradiol/norethindrone aspirin/dipyridamole nifedipine ER acetate Vecamyl quinine sulfate capsule aspirin/omeprazole nimodipine estropipate verapamil HCL cilostazol nisoldipine Nausea, vomiting Forteo verapamil HCL ER, SR clopidogrel bisulfate Nitro-Bid Akynzeo fortical dipyridamole nitroglycerin, dis, sl, spr High cholesterol Anzemet fyavolv prasugrel Nitro-Time atorvastatin aprepitant ibandronate Zontivity Nymalize cholestyramine Cesamet jenatique lo olmesartan jinteli cholestyramine light chlorpromazine HCL Vaccines olmesartan/HCTZ lopreeza colesevelam HCL Compro All brand and generic perindopril colestipol HCL dimenhydrinate medroxyprogesterone versions are included. acetate pindolol ezetimibe dronabinol Menest Vitamins prazosin HCL fenofibrate capsule doxylamine/pyridoxine (except 50mg and 150mg) mimvey Formulary options Prestalia fosaprepitant fenofibrate micronized mimvey lo prenatal vitamins propranolol HCL (except 43mg and 130mg) granisetron HCL (taken during pregnancy) norethindrone acetate/ propranolol HCL ER fenofibrate tablet ondansetron HCL ethinyl estradiol prescription multivitamins (except 40mg and 120mg) with fluoride propranolol/HCTZ ondansetron ODT Prefest gemfibrozil prescription multivitamins Qbrelis palonosetron HCL Premarin tab with fluoride and iron lovastatin quinapril HCL phenadoz Premphase niacin ER quinapril/HCTZ prochlorperazine Prempro Weight loss niacor ramipril promethazine HCL Prolia benzphetamine HCL omega-3-acid cap 1 gm ranolazine ER Sancuso raloxifene Contrave pravastatin sorine scopolamine patch risedronate diethylpropion HCL prevalite sotalol HCL Syndros Tymlos diethylpropion rosuvastatin sotalol HCL af Tigan inj zoledronic acid Lomaira simvastatin (generic Reclast) Sotylize trimethobenzamide HCL phendimetrazine spironolactone triklo phentermine HCL Varubi RSV spironolactone/HCTZ Vascepa (respiratory Qsymia syncytial virus) taztia XT Osteoporosis Xenical Synagis telmisartan alendronate sodium terazosin HCL amabelz Anthem Blue Cross is the trade name of Blue Cross of California. Independent licensee of the Blue Cross Association. Anthem is a registered trademark of Anthem Insurance Companies, Inc. .
Recommended publications
  • Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications
    International Journal of Molecular Sciences Review Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications Daniel Fernández-Villa 1, Maria Rosa Aguilar 1,2 and Luis Rojo 1,2,* 1 Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Científicas, CSIC, 28006 Madrid, Spain; [email protected] (D.F.-V.); [email protected] (M.R.A.) 2 Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, 28029 Madrid, Spain * Correspondence: [email protected]; Tel.: +34-915-622-900 Received: 18 September 2019; Accepted: 7 October 2019; Published: 9 October 2019 Abstract: Bacterial, protozoan and other microbial infections share an accelerated metabolic rate. In order to ensure a proper functioning of cell replication and proteins and nucleic acids synthesis processes, folate metabolism rate is also increased in these cases. For this reason, folic acid antagonists have been used since their discovery to treat different kinds of microbial infections, taking advantage of this metabolic difference when compared with human cells. However, resistances to these compounds have emerged since then and only combined therapies are currently used in clinic. In addition, some of these compounds have been found to have an immunomodulatory behavior that allows clinicians using them as anti-inflammatory or immunosuppressive drugs. Therefore, the aim of this review is to provide an updated state-of-the-art on the use of antifolates as antibacterial and immunomodulating agents in the clinical setting, as well as to present their action mechanisms and currently investigated biomedical applications. Keywords: folic acid antagonists; antifolates; antibiotics; antibacterials; immunomodulation; sulfonamides; antimalarial 1.
    [Show full text]
  • Adrenal Disorders
    Adrenal Disorders Dual-release Hydrocortisone in Addison’s Disease— A Review of the Literature Roberta Giordano, MD,1 Federica Guaraldi, MD,2 Rita Berardelli, MD,2 Ioannis Karamouzis, MD,2 Valentina D’Angelo, MD,2 Clizia Zichi, MD,2 Silvia Grottoli, MD,2 Ezio Ghigo, PhD2 and Emanuela Arvat, PhD3 1. Department of Clinical and Biological Sciences; 2. Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences; 3. Division of Oncological Endocrinology, Department of Medical Sciences, University of Turin, Turin, Italy Abstract In patients with adrenal insufficiency, glucocorticoids (GCs) are insufficiently secreted and GC replacement is essential for health and, indeed, life. Despite GC-replacement therapy, patients with adrenal insufficiency have a greater cardiovascular risk than the general population, and suffer from impaired health-related quality of life. Although the aim of the replacement GC therapy is to reproduce as much as possible the physiologic pattern of cortisol secretion by the normal adrenal gland, the pharmacokinetics of available oral immediate-release hydrocortisone or cortisone make it impossible to fully mimic the cortisol rhythm. Therefore, there is an unmet clinical need for the development of novel pharmaceutical preparations of hydrocortisone, in order to guarantee a more physiologic serum cortisol concentration time-profile, and to improve the long-term outcome in patients under GC substitution therapy. Keywords Addison’s disease, glucocorticoids, hydrocortisone, Plenadren®, limits, advantages Disclosure: The authors have no conflicts of interest to declare. Received: June 28, 2013 Accepted: August 9, 2013 Citation: US Endocrinology 2013;9(2):177–80 DOI: 10.17925/USE.2013.09.02.177 Correspondence: Roberta Giordano, MD, Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, Azienda Ospedaliera Città della Salute e della Scienza di Torino, C so Dogliotti 14, 10126 Turin, Italy.
    [Show full text]
  • Infection Prevention in Combat-Related Injuries CPG ID: 24 APPENDIX B: POST-INJURY ANTIMICROBIAL AGENT SELECTION and DURATION BASED UPON INJURY PATTERN
    Infection Prevention in Combat-Related Injuries CPG ID: 24 APPENDIX B: POST-INJURY ANTIMICROBIAL AGENT SELECTION AND DURATION BASED UPON INJURY PATTERN INJURY PREFERRED AGENT(S) ALTERNATE AGENT(S) DURATION EXTREMITY WOUNDS (INCLUDES SKIN, SOFT TISSUE, BONE) Skin, soft tissue, no open fractures Cefazolin, 2 gm IV q6-8h†‡ Clindamycin (300-450 mg PO TID or 600 mg IV q8h) 1-3 days Skin, soft tissue, with open Cefazolin 2 gm IV q6-8h†‡§ Clindamycin 600 mg IV q8h 1-3 days fractures, exposed bone, or open joints THORACIC WOUNDS Penetrating chest injury without Cefazolin, 2 gm IV q6-8h†‡ Clindamycin (300-450 mg PO TID or 600 mg IV q8h) 1 day esophageal disruption Penetrating chest injury with Cefazolin 2 gm IVq 6-8h†‡ PLUS metronidazole 500 Ertapenem 1 gm IV x 1 dose, OR moxifloxacin 400 mg 1 day after definitive esophageal disruption mg IV q8-12h IV x 1 dose washout ABDOMINAL WOUNDS Penetrating abdominal injury with Cefazolin 2 gm IV q 6-8h†‡ PLUS metronidazole 500 Ertapenem 1 gm IV x 1 dose, OR moxifloxacin 400 mg 1 day after definitive suspected/known hollow viscus mg IV q8-12h IV x 1 dose washout injury and soilage; may apply to rectal/perineal injuries as well MAXILLOFACIAL AND NECK WOUNDS Open maxillofacial fractures, or Cefazolin 2 gm IV q6-8h†‡ Clindamycin 600 mg IV q8h 1 day maxillofacial fractures with foreign body or fixation device CENTRAL NERVOUS SYSTEM WOUNDS Penetrating brain injury Cefazolin 2 gm IV q6-8h.†‡ Consider adding Ceftriaxone 2 gm IV q24h. Consider adding 5 days or until CSF metronidazole 500 mg IV q8-12h if gross metronidazole 500 mg IV q8-12h if gross contamination with organic debris contamination with organic debris.
    [Show full text]
  • Belgian Veterinary Surveillance of Antibacterial Consumption
    Belgian Veterinary Surveillance of Antibacterial Consumption National consumption report 2013 1 Summary This fifth BelVetSAC report, covers the results of the data collection on veterinary antibacterial consumption in Belgium in the year 2013. Data consist of all veterinary antibacterials sold to a veterinarian or pharmacist in Belgium and of antibacterial premixes incorporated in medicated feed intended to be used in Belgium for the year 2013. It includes thus consumption data for farm animals as well as companion animals. The denominator for animal production was the biomass (in kg) calculated as the sum of the amount of beef, pork and poultry meat produced in 2013, plus the number of dairy cattle present in Belgium times 500 kg of metabolic weight per head. As the usage data are concerned, this report shows for the second year in a row a decrease in the total consumption of antibacterial compounds in veterinary medicine of -6,6% between 2012 and 2013. Due to the relative stable animal production (expressed in biomass -0,3%) the decrease expressed in mg/kg biomass is -6,3%. When using 2011 as a reference, a reduction of -12,7% (expressed in mg/kg biomass) was achieved between 2011 and 2013, distributed over a reduction of -13,3% in antibacterial pharmaceuticals and -10,2% in antibacterial premixes. When looking more in detail to the different types of antibacterials used, it is observed that the penicillines (31,1%), sulphonamides (28,7%), and tetracyclines (24,1%) remain the three most used antibacterial classes. This year a substantial decrease in sulphonamide plus trimethoprim use and a limited decrease in penicillin and tetracycline use was observed.
    [Show full text]
  • Frequently Asked Questions for Addison Patients
    FREQUENTLY ASKED QUESTIONS FOR ADDISON PATIENTS TABLE OF CONTENT (Place your cursor over the subject line, hold down the Control Button and Click your mouse. To get back to the Table of Content, hold down the Control Button and press the Home key) ADDISONIAN CRISIS / EMERGENCY ADDISONS AND OTHER DISORDERS ADDISONS AND OTHER MEDICATIONS ADRENALINE BLOOD PRESSURE COMMON COLD/FLU/OTHER ILLNESS CORTISOL DAY CURVE CORTISOL MEDICATION CRAMPS DIABETES DIAGNOSING ADDISONS EXERCISE / SPORTS FATIGUE FLORINEF / SALT / SODIUM HERBAL / VITAMIN SUPPLEMENTS HYPERPIGMENTATION IMMUNIZATION MENOPAUSE, PREGNANCY, HORMONE REPLACEMENT, BIRTH CONTROL, HYSTERECTOMY MISCELLANEOUS OSTEOPOROSIS SECONDARY ADDISON’S SHIFT WORK SLEEP 1 STRESS DOSING SURGICAL, MEDICAL, DENTAL PROCEDURES THYROID TRAVEL WEIGHT GAIN 2 ADDISONIAN CRISIS / EMERGENCY How do you know when to call an ambulance? If you are careful, you should not have to call an ambulance. If someone with adrenal insufficiency has gastrointestinal problems and is unable to keep down their cortisol or other glucocorticoid for more than 24 hrs, they should be taken to an emergency department so they can be given intravenous solucortef and saline. It is not appropriate to wait until they are so ill that they cannot be taken to the hospital by a family member. If the individual is unable to retain anything by mouth and is very ill, or if they have had a sudden stress such as a fall or an infection, then it would be necessary for them to go by ambulance as soon as possible. It is important that you should have an emergency kit at home and that someone in the household knows how to use it.
    [Show full text]
  • Steroid Use in Prednisone Allergy Abby Shuck, Pharmd Candidate
    Steroid Use in Prednisone Allergy Abby Shuck, PharmD candidate 2015 University of Findlay If a patient has an allergy to prednisone and methylprednisolone, what (if any) other corticosteroid can the patient use to avoid an allergic reaction? Corticosteroids very rarely cause allergic reactions in patients that receive them. Since corticosteroids are typically used to treat severe allergic reactions and anaphylaxis, it seems unlikely that these drugs could actually induce an allergic reaction of their own. However, between 0.5-5% of people have reported any sort of reaction to a corticosteroid that they have received.1 Corticosteroids can cause anything from minor skin irritations to full blown anaphylactic shock. Worsening of allergic symptoms during corticosteroid treatment may not always mean that the patient has failed treatment, although it may appear to be so.2,3 There are essentially four classes of corticosteroids: Class A, hydrocortisone-type, Class B, triamcinolone acetonide type, Class C, betamethasone type, and Class D, hydrocortisone-17-butyrate and clobetasone-17-butyrate type. Major* corticosteroids in Class A include cortisone, hydrocortisone, methylprednisolone, prednisolone, and prednisone. Major* corticosteroids in Class B include budesonide, fluocinolone, and triamcinolone. Major* corticosteroids in Class C include beclomethasone and dexamethasone. Finally, major* corticosteroids in Class D include betamethasone, fluticasone, and mometasone.4,5 Class D was later subdivided into Class D1 and D2 depending on the presence or 5,6 absence of a C16 methyl substitution and/or halogenation on C9 of the steroid B-ring. It is often hard to determine what exactly a patient is allergic to if they experience a reaction to a corticosteroid.
    [Show full text]
  • Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
    [Show full text]
  • Corticosteroids in Terminal Cancer-A Prospective Analysis of Current Practice
    Postgraduate Medical Journal (November 1983) 59, 702-706 Postgrad Med J: first published as 10.1136/pgmj.59.697.702 on 1 November 1983. Downloaded from Corticosteroids in terminal cancer-a prospective analysis of current practice G. W. HANKS* T. TRUEMAN B.Sc., M.B., B.S., M.R.C.P.(U.K.) S.R.N. R. G. TWYCROSS M.A., D.M., F.R.C.P. Sir Michael Sobell House, The Churchill Hospital, Headington, Oxford OX3 7LJ Summary Introduction Over half of a group of 373 inpatients with advanced Corticosteroids have a major role to play in the malignant disease were treated with corticosteroids control of symptoms in patients with advanced for a variety of reasons. They received either pred- malignant disease. They may be employed in a non- nisolone or dexamethasone, or replacement therapy specific way to improve mood and appetite; or they with cortisone acetate. Forty percent of those receiv- may be indicated as specific adjunctive therapy in the ing corticosteroids benefited from them. A higher relief of symptoms related to a large tumour mass or response rate was seen when corticosteroids were to nerve compression. The management of a numberProtected by copyright. prescribed for nerve compression pain, for raised of other symptoms and syndromes may also be intracranial pressure, and when used in conjunction facilitated by treatment with corticosteroids (Table with chemotherapy. No significant difference in 1). efficacy was noted between the 2 drugs. The results, The use of corticosteroids in patients with ad- however, suggest that with a larger sample, dexame- vanced cancer is empirical, as it is in other non- thasone would have been shown to be significantly endocrine indications.
    [Show full text]
  • Design, Synthesis and Pharmacological Evaluation of Sulfanilamide-Ciprofloxacin Conjugates Utilizing Hybridization Approach As New Antibacterial Agents
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by International Institute for Science, Technology and Education (IISTE): E-Journals Journal of Natural Sciences Research www.iiste.org ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online) Vol.5, No.4, 2015 Design, Synthesis and Pharmacological Evaluation of Sulfanilamide-Ciprofloxacin Conjugates Utilizing Hybridization Approach as New Antibacterial Agents Mohamed Hassan Mohammed 1 Monther Faisal Mahdi 2 Noor Hatef Naser 3 Sulaf Majeed Ali 4 1.Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq 2.Department of Pharmaceutical Chemistry, College of Pharmacy, University of Al-Mustansiriyah, Baghdad, Iraq 3.Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa,Najaf, Iraq 4.Ministry of Health, Directorate of General Health National Reference Laboratory E-Mail of Corresponding author :[email protected] Abstract A group of novel antibacterial agents (I-V) were designed and synthesized, by utilizing hybridization approach between ciprofloxacin and sulfanilamide, through metabolically stable linkers, to be acted by dual mode of actions. Ciprofloxacin acts by inhibition of topoisomerase enzyme, which is necessary for DNA replication, while sulfonamides act through inhibition of carbonic anhydrase enzyme, which is necessary for bacterial metabolic activity. Anti-tuberculosis activity of these compounds was evaluated on MDR Mycobacterium tuberculosis (resist to rifampicin and INH), in a dose equivalent to (10 mg/ 5 ml D.W.) of ciprofloxacin. Compounds II, III showed non-significant reduction in the number of bacterial colonies (bacterial growth) with respect to the effect of ciprofloxacin (standard), compound IV produce a significant reduction in the number of bacterial colonies in comparable to ciprofloxacin.
    [Show full text]
  • Sulfonamides and Sulfonamide Combinations*
    Sulfonamides and Sulfonamide Combinations* Overview Due to low cost and relative efficacy against many common bacterial infections, sulfonamides and sulfonamide combinations with diaminopyrimidines are some of the most common antibacterial agents utilized in veterinary medicine. The sulfonamides are derived from sulfanilamide. These chemicals are structural analogues of ρ-aminobenzoic acid (PABA). All sulfonamides are characterized by the same chemical nucleus. Functional groups are added to the amino group or substitutions made on the amino group to facilitate varying chemical, physical and pharmacologic properties and antibacterial spectra. Most sulfonamides are too alkaline for routine parenteral use. Therefore the drug is most commonly administered orally except in life threatening systemic infections. However, sulfonamide preparations can be administered orally, intramuscularly, intravenously, intraperitoneally, intrauterally and topically. Sulfonamides are effective against Gram-positive and Gram-negative bacteria. Some protozoa, such as coccidians, Toxoplasma species and plasmodia, are generally sensitive. Chlamydia, Nocardia and Actinomyces species are also sensitive. Veterinary diseases commonly treated by sulfonamides are actinobacillosis, coccidioidosis, mastitis, metritis, colibacillosis, pododermatitis, polyarthritis, respiratory infections and toxo- plasmosis. Strains of rickettsiae, Pseudomonas, Klebsiella, Proteus, Clostridium and Leptospira species are often highly resistant. Sulfonamides are bacteriostatic antimicrobials
    [Show full text]
  • Third ESVAC Report
    Sales of veterinary antimicrobial agents in 25 EU/EEA countries in 2011 Third ESVAC report An agency of the European Union The mission of the European Medicines Agency is to foster scientific excellence in the evaluation and supervision of medicines, for the benefit of public and animal health. Legal role Guiding principles The European Medicines Agency is the European Union • We are strongly committed to public and animal (EU) body responsible for coordinating the existing health. scientific resources put at its disposal by Member States • We make independent recommendations based on for the evaluation, supervision and pharmacovigilance scientific evidence, using state-of-the-art knowledge of medicinal products. and expertise in our field. • We support research and innovation to stimulate the The Agency provides the Member States and the development of better medicines. institutions of the EU the best-possible scientific advice on any question relating to the evaluation of the quality, • We value the contribution of our partners and stake- safety and efficacy of medicinal products for human or holders to our work. veterinary use referred to it in accordance with the • We assure continual improvement of our processes provisions of EU legislation relating to medicinal prod- and procedures, in accordance with recognised quality ucts. standards. • We adhere to high standards of professional and Principal activities personal integrity. Working with the Member States and the European • We communicate in an open, transparent manner Commission as partners in a European medicines with all of our partners, stakeholders and colleagues. network, the European Medicines Agency: • We promote the well-being, motivation and ongoing professional development of every member of the • provides independent, science-based recommenda- Agency.
    [Show full text]
  • Cortisone Acetate Tablets, Usp
    CORTISONE ACETATE- cortisone acetate tablet Hikma Pharmaceuticals USA Inc. ---------- CORTISONE ACETATE TABLETS, USP Rev. 07/09 Rx Only DESCRIPTION: Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Cortisone acetate is a white or practically white, odorless, crystalline powder. It is stable in air. It is insoluble in water. The molecular weight is 402.49. It is designated chemically as 21-(acetyloxy)-17- hydroxypregn-4-ene-3,11,20-trione. The molecular formula is C23H30O6 and the structural formula is: Cortisone Acetate tablets contain 25 mg of cortisone acetate in each tablet. Inactive ingredients are Anhydrous Lactose, Colloidal Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose, Sodium Lauryl Sulfate, and Sodium Starch Glycolate. CLINICAL PHARMACOLOGY: Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. They are also used for their potent anti-inflammatory effects in disorders of many organ systems. Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. INDICATIONS AND USAGE: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation
    [Show full text]