Generated by SRI International Pathway Tools Version 25.0, Authors S

Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000204415Cyc: Methanothrix soehngenii GP6 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari molybdate molybdate phosphate phosphate

ammonium ammonium ammonium phosphate

predicted ABC ModA RS06695 RS02690 RS02700 RS14600 PstB RS11170 transporter of molybdate

molybdate ammonium ammonium ammonium phosphate phosphate phosphate molybdate

Cofactor, Carrier, and Vitamin Biosynthesis

5,10-methylene- an [eIF5A- a [bis(guanylyl a [protein]- (indol-3- a mismatched an adenosine 34 Nucleoside and Nucleotide Degradation a polycistronic spermidine serotonin coenzyme A a D-tyrosyl- Fe 2+ sirohydrochlorin cob(II)yrinate a,c- Arg2 adenosylcobinamide-GDP molybdenum adenosylcobalamin biosynthesis Fatty Acid and Lipid Biosynthesis methanogenesis from H and CO Respiration tetrahydromethanopterin precursor]-lysine molybdopterin) cys L-glutamine yl)pyruvate DNA base pair Tyr in [tRNA ] [2Fe-2S] iron-sulfur cob(II)yrinate a,c- factor 430 biosynthesis factor 420 biosynthesis I (archaea) 5-methylbenzimidazolyl 2 2 tRNA precursor GTP [tRNA ] ATP ATP diamide biosynthesis I salvage from cobinamide II cofactor DNA NMN biotin Flp pilus cluster biosynthesis diamide biosynthesis II cofactor biosynthesis adenosylcobamide biosynthesis from adenosylcobinamide-GDP I (early cobalt insertion) nucleoside and nucleotide degradation (archaea) chaperone]- mismatch assembly (late cobalt incorporation) from adenosylcobinamide-GDP CDP-archaeol biosynthesis CO formaldehyde- deoxyhypusine transglutaminase indolepyruvate bifunctional uroporphyrinogen-III ARP coenzyme B/coenzyme M regeneration 2 repair protein uroporphyrinogen-III cob(II)inamide molybdate 5,6-dimethylbenzimidazole biotin-carboxyl carrier protein assembly tRNA- L-cysteine D-aminoacyl- complex L-cysteine desulfurase uroporphyrinogen-III 5-methylbenzimidazole activating synthase: domain-containing ferredoxin precorrin-2 I (methanophenazine-dependent) formylmethanofuran intron bifunctional MutS: mutS tRNA deacylase: nicotinamide- biotin--[acetyl- ATPase 5-amino-6-(D- predicted adenosine guanosine enzyme: fae MCON_RS13385 protein: oxidoreductase dehydrogenase/ DHAP a [biotin carboxyl- dehydrogenase: lyase: 3,4-dihydroxy- DNA mismatch MCON_RS00630 nucleotide CoA-carboxylase] component cysteine cysteine MCON_RS15300 subunit alpha: sirohydrochlorin precorrin-1 ribitylamino) H ABC uridine bifunctional 5,6,7,8- deoxyhypusine 2-butanone- adenylyltransferase: ligase: TadA: tadA precorrin-1 2 carrier protein]-L-lysine MCON_RS04115 endA desulfurase repair desulfurase: uracil--L- transporter tetrahydromethanopterin synthase: MCON_RS13405 ferrochelatase: an inosine 34 precorrin-1 [corrinoid [+ 2 isozymes] 4-phosphate protein MutS: MCON_RS10180 MCON_RS06370 MCON_RS11720 tyrosine 4- Coenzyme F420 NAD(P)-dependent biotin--[acetyl-CoA- cytidine NifS: nifS 6 MCON_RS06430 Arg2 adenosyltranferase]- of molybdate: α uridine adenosine guanosine hydro-lyase/3-hexulose- MCON_RS12965 synthase/GTP a [protein] N - [+ 2 isozymes] Tyr in [tRNA ] adenosylcobinamide- 5-methylbenzimidazole adenosylcobinamide-GDP -ribazole 5'-phosphate glycerol-1- carboxylase] ligase: a 3'-half-tRNA a 5'-half-tRNA a tRNA intron MCON_RS09065 D-tyrosine a tRNA cysteine hydroxyphenyl hydrogenase/ modA modB phosphorylase: 6-phosphate synthase: cysteine [(5-hydroxy-1H- cob(II)inamide ribotide phosphate a formylmethanofuran phosphorylase: phosphorylase: cyclohydrolase II: a properly matched dehydrogenase, GDP phosphate MCON_RS06370 molecule with molecule with with a 2',3'-cyclic desulfurase: + biotinyl-5'- desulfurase transferase AMP MCON_RS02525 MCON_RS14590 MCON_RS14590 MCON_RS05920 an [eIF5A- MCON_RS04985 indol-3-yl)ethyl]- DNA base pair NAD molybdate dehydrogenase: GGPP a 5'-OH end a 2',3'-cyclic phosphate and propane- (indol-3 yl) adenylate NifS: nifS precorrin-2 CofH: cofH beta subunit C- adenosylcobinamide-GDP a [biotin carboxyl-carrier formylmethanofuran-- precursor]- MCON_RS11720 L-glutamine siroheme precorrin-2 ABC adenosylcobinamide- MCON_RS04570 6 UMP CMP phosphate end a 5'-hydroxyl 1,3-diamine acetyl-CoA precorrin-2 5-amino-5-(4- terminal domain: ribazoletransferase: cobS protein]-N -biotinyl-L-lysine tetrahydromethanopterin transporter α-D-ribose- deoxyhypusine an S-sulfanyl-[L- bifunctional [corrinoid MCON_RS09865 GDP N-formyltransferase: fhcD terminus 2,5-diamino-6- bifunctional hydroxybenzyl)- molybdopterin 1-phosphate formaldehyde THMPT a [bis(guanylyl cysteine desulfurase] adenosyltranferase]- substrate- ribazoletransferase: AMP AMP AMP (5-phospho-D- formate precorrin-2 6-(D-ribitylimino) 4-amino-2-methyl-5- sn-glycerol 5-formyl- ala molybdopterin) precorrin-2 Coenzyme F420 binding phosphorylase: phosphorylase: phosphorylase: dehydrogenase/ cob(I)inamide cobS adenosylcobalamin 5'-phosphate ribosylamino) dehydrogenase/ -5,6-dihydrouracil hydrogenase/ diphosphomethylpyrimidine 1-phosphate tetrahydromethanopterin cofactor protein: a [biotin carboxyl-carrier-protein MCON_RS02525 MCON_RS02525 MCON_RS02525 pyrimidin- sirohydrochlorin 2-phospho- 7,8-didemethyl- biosynthesis I chaperone]-S- sirohydrochlorin dehydrogenase, modA Coα-[α-(5- 6 methenyltetrahydromethanopterin precorrin-3A ferrochelatase: L-lactate alpha-ribazole dimer]-N -biotinyl-L-lysine 4(3H)-one ferrochelatase: 8-hydroxy-5- beta subunit C- molybdopterin phosphoglycerol sulfanyl-L-cysteine an S-sulfanyl-[cysteine methylbenzimidazolyl)]- AIR cyclohydrolase: MCON_RS05530 α-D-ribose 1,5- MCON_RS06430 2-phospho-L-lactate deazariboflavin adenine phosphatase CobZ: cobZ acetyl-CoA MCON_RS06430 desulfurase]-[disordered- terminal domain: molybdate Coβ-adenosylcobamide phosphomethylpyrimidine geranylgeranyltransferase: acetyl-CoA adenosylcobinamide carboxylase biotin bisphosphate guanylyltransferase: synthase subunit MCON_RS15365 dinucleotide MCON_RS08235 H 5,10-methenyltetrahydromethanopterin form scaffold sirohydrochlorin 5'-phosphate synthase ThiC: thiC carboxyltransferase: 2 UTP and CTP dephosphorylation I sn-glycero-3- an N-terminal- an N-terminal- adenosylcobalamin carboxylase subunit: a [DNA]-3'- + a 5'-phospho- an (R)-2- a nucleoside a [DNA]-3'- a 5'-phospho- an L-asparaginyl- sirohydrochlorin cofC CofG: cofG ribose 1,5- NAD 3-methylbutanoate MoO - 5'-phospho- PRPP quinolinate protein] complex adenosylcobinamide alpha-ribazole phosphomethylpyrimidine MCON_RS06365 2 phospho-N- RNA Asn L-methionyl-L- L-methionyl- asp L-lactyl-2- 7,8-didemethyl- a reduced molybdopterin MCON_RS06365 hydroxyl [DNA] halocarboxylate GTP triphosphate GTP hydroxyl [DNA] [tRNA ] [cysteine desulfurase]-S- sirohydrochlorin amidohydrolase: UTP bisphosphate molybdopterin ribonucleotide- glycyl-[protein] sirohydrochlorin precorrin-3B factor 420 phosphatase synthase ThiC: thiC cytidylyl molybdenum (arachidonoyl) alanyl-[protein] asparagine sulfanylcysteine:[acceptor diphospho- 8-hydroxy-5- H molybdotransferase GGGP isomerase: His nickelochelatase: MCON_RS02870 2 CobZ: cobZ HMP-P a [carboxyl-carrier protein dimer]- cofactor ethanolamine [tRNA ] cobaltochelatase: 5'-guanosine deazariboflavin (R)-1-amino- cofactor sulfurylation synthase protein]-cysteine precorrin-3B (C 17 )- cfbA MoeA: Coα-[α-(5- N 6 -carboxybiotinyl-L-lysine CTP synthase: MCON_RS00870 ATP-dependent CO dehydrogenase/ HAD family ATP-dependent carboxylating MCON_RS03220 2-propanol O F420H2 DNA-directed peptidyl-tRNA type II methionyl type II methionyl sulfurtransferase: nifS adenosylcobyrate MCON_RS12265 geranylgeranylglycerol- 5,10-methylene- DNA ligase: hydrolase: DNA ligase: nicotinate- (glutamine- methyltransferase: methylbenzimidazolyl)]- bifunctional cytidylyl molybdenum MCON_RS06590 D-ribulose-1,5- acetyl-CoA tRNA(His) sirohydrochlorin a [cysteine desulfurase]- Ni-sirohydrochlorin 2-phospho-L- -2-phosphate F non-reducing dehydrogenase phosphate Carboxylate Degradation molybdenum cofactor glycerophosphoryl RNA polymerase: hydrolase: aminopeptidase: aminopeptidase: hydrolyzing) cobM 420 Coβ-adenosylcobamide hydroxymethylpyrimidine cofactor (trioxo) tetrahydromethanopterin bisphosphate MCON_RS03430 synthase complex: MCON_RS07050 MCON_RS03430 nucleotide S-sulfanyl-[disordered- lactate transferase: hydrogenase: subunit MoO - geranylgeranyltransferase: UDP guanylyltransferase: diester MCON_RS10870 guanylyltransferase: MCON_RS13430 MCON_RS08225 MCON_RS08225 : asnB cobaltochelatase: 2 diphosphorylase: kinase/ 5,10-methylenetetrahydromethanopterin CTP DNA ligase: MCON_RS05680 HAD family MCON_RS13080 MCON_RS12305 form scaffold precorrin-4 Ni-sirohydrochlorin MCON_RS04600 MCON_RS09865 FpoO: fpoO molybdopterin MCON_RS00620 ribulose- MCON_RS00955 phosphodiesterase: MCON_RS10880 phosphomethylpyrimidine 2-oxobutanoate MCON_RS06665 cdhD cdhB cdhA hydrolase: nadC asn protein] complex a,c-diamide cofactor an [MCD cofactor 2,3-bis-O- reductase: mer bisphosphate [+ 7 isozymes] cobalt- adeninyl adenosylcobamide degradation II molybdopterin- MCON_RS02480 [DNA] an N-terminal L- an N-terminal cysteine kinase: MCON_RS07260 chaperone]-MCD acetate conversion [+ 5 isozymes] MCON_RS11655 precorrin-4 C(11)- synthase: cfbB oxidized adenosyl- CoB-CoM biosynthesis from (geranylgeranyl) carboxylase: guanine 5'-phospho- asn tRNA Asn met met sirohydrochlorin desulfurase: dihydromethanophenazine N 5 -methyltetrahydromethanopterin UMP to acetyl-CoA alanyl-[protein] glycyl-[protein] methyltransferase: cobinamide heterodisulfide phosphopantothenate bifunctional cysteine -sn-glycerol MCON_RS13090 guanosine- Ni-sirohydrochlorin factor 420-0 adenosylcobinamide-GDP CDP 2-oxobutanoate dinucleotide NaMN cobalt-factor II C(20) MCON_RS11720 biosynthesis III (archaea) [DNA] NMN sn-glycerol cobM a,c-diamide phosphate hydroxymethylpyrimidine desulfurase: 1-phosphate 5'/3'- 3-phospho- AMP 3-methylbutanoyl- an (S)-2- biosynthesis anandamide RNA ribonucleotide- -methyltransferase: tetrahydromethanopterin 2-oxoacid:ferredoxin acetate a halide anion cysteine heterodisulfide kinase/ MCON_RS11720 nucleotidase diphosphate 3-phosphate [tRNA His ] Ni-sirohydrochlorin adenine 3-methyl-2- methyl-coenzyme M D-glycerate oxidoreductase AMP CoA hydroxycarboxylate protein B: mobB MCON_RS07240 desulfurase precorrin-5 S-methyltransferase: mtrH CO dehydrogenase/ reductase: oxobutanoate phosphomethylpyrimidine cysteine CDP-2,3-bis-(O- 2,3-bis-O- reduction to methane SurE: surE a,c-diamide mtrG MCON_RS04630 subunit beta: acetyl-CoA NifS: nifS an oxidized MCON_RS14450 kinase: thiD geranylgeranyl)-sn- (geranylgeranyl) CMP cobalt-factor III an S-sulfanyl-[cysteine reductive cyclase desulfurase MCON_RS11295 guanylyl factor 420 adenosylcobinamide- MCON_RS04635 uridine synthase complex: NifS: nifS glycerol synthase: -sn-glycerol methyl-CoM propanoyl-CoA desulfurase]-S- ATP-dependent GDP HMP-PP MCON_RS04640 5'/3'- MCON_RS05680 molybdenum F420-dependent 2-dehydropantoate a [cytidylyl molybdenum MCON_RS04660 1-phosphate coenzyme-B sulfanyl-[disordered- reductase coenzyme M coenzyme B MCON_RS04645 nucleotidase cdhD cdhB cdhA cofactor methylenetetrahydromethanopterin cofactor chaperone]- reductase: sulfoethylthiotransferase: form scaffold precorrin-6A subunit: cfbC 2-dehydropantoate Carbohydrate Biosynthesis MCON_RS04650 SurE: surE dehydrogenase: MCON_RS04560 unsaturated MCON_RS13910 mcrA mcrG mcrB [+ 5 isozymes] protein] complex adenine ribotide cytidylyl molybdenum MCON_RS04655 [+ 2 isozymes] 2-reductase: methane cytidine acetyl-CoA a guanine 34 an N-terminal- a peptide with cobalt-precorrin-3 [cysteine desulfurase]-S- a reduced adenosylcobinamide- phosphate 4-aminobenzoate cofactor (sulfo-dioxo) CDP-archaeol an (S)-2- + a ribonucleoside 3 isobutanoate 2-methylbutanoate menadione NADH H preQ MoO - dimethylarsonite Ala Asx 15,17 -seco- MCON_RS02125 2,3-bis-O- gluconeogenesis I tetrahydromethanopterin 1 formate 2 a glycyl-[tRNA ] L-methionyl-L- an N-terminal a tRNA asp sulfanylcysteine:[acceptor factor 420 GDP biosynthesis PRPP biosynthesis propanoate halocarboxylate in tRNA triphosphate ATP dITP cobalt-precorrin 3 3 molybdopterin arsenite protein]-cysteine F430-17 -acid phytanyl-sn S-methyltransferase: seryl-[protein] L-methionine methyltransferase: (R)-pantoate cofactor methyltransferase: sulfurtransferase: nifS precorrin-6B coenzyme -glycerol 1- MCON_RS12210 mtrH XTP/dITP a [cysteine coenzyme M adenosylcobinamide- chorismate (S)-malate D-ribose 5- CO dehydrogenase/acetyl- CO dehydrogenase/ HAD family NADH-quinone tRNA MCON_RS15170 phosphate C1 Compound Utilization and Assimilation anaerobic MCON_RS12800 desulfurase]-(S- F430 FeMo cofactor biosynthesis pantoate kinase: aminodeoxychorismate/ phosphate D-aminoacyl- type II methionyl type II methionyl aspartate-- diphosphatase: biosynthesis II GDP ribose-phosphate methyl-CoM CoA synthase complex: acetyl-CoA hydrolase: oxidoreductase: guanosine(34) synthase: CDP-2,3-bis-(O- ribonucleoside- molybdenum cofactor arsenite tRNA deacylase: aminopeptidase: aminopeptidase: tRNA(Asn) MCON_RS03990 cobalt-precorrin-4 sulfanyl) -[disordered- ribazoletransferase: MCON_RS14615 anthranilate synthase Alcohol Degradation MCON_RS05680 synthase complex: MCON_RS07050 nuoB transglycosylase 2 diphosphokinase: reductive acetyl coenzyme A pathway II (autotrophic methanogens) triphosphate guanylyltransferase: methyltransferase: MCON_RS00630 MCON_RS08225 MCON_RS08225 form scaffold cfbE a [4Fe-4S] iron- O-phospho- cobS component II: geranylgeranyl)-sn- Tgt: tgt ligase: aspS (R)-4- MCON_RS06915 cdhD cdhB cdhA MCON_RS05680 HAD family MCON_RS15750 MCON_RS00955 cobalt precorrin- sulfur cluster L-serine MCON_RS05575 glycerol synthase: NAD-dependent reductase: nrdD arsM dIMP protein] complex oxidized NAD-dependent PRPP glycerophosphodiester cdhD cdhB cdhA nuoH nuoK 11 precorrin-7 phosphopantoate 4-amino-4- [+ 5 isozymes] hydrolase: 4 (C )- coenzyme F430 cysteate synthase: Coα-[α-(adenin-9-yl)]- MCON_RS04660 malic enzyme 4: CO trimethylarsine malic enzyme 4: 2 degradation a 7-aminomethyl-7- an N-terminal β phosphopantothenate/ deoxychorismate [+ 5 isozymes] MCON_RS11655 NADH-quinone adenylyl Ala an L-aspartyl- methyltransferase: MCON_RS00830 Co -adenosylcobamide MCON_RS08245 methyl-coenzyme M oxidation to CO 34 a 2'- a tRNA saturated MCON_RS08245 2 deazaguanosine gly met L-seryl-[protein] met a peptide Asx L-cysteate pantothenate oxidoreductase molybdenum [tRNA ] cobM 5'-phosphate CDP-archaeol formylmethanofuran guanine deoxyribonucleoside a glycerophosphodiester isobutanoyl-CoA diphosphate (2S)-2- in tRNA a [cysteine desulfurase]- alpha-ribazole synthetase: pyridoxal 5'-phosphate biosynthesis II dehydrogenase: AMP an (S)-2- subunit 5'-triphosphate cofactor cobalt- a NifB protein cysteate methyl-CoM glycerophosphoryl a halide anion [scaffold protein- MCON_RS14610 MCON_RS04115 methylbutanoyl- diphosphate NuoE: nuoE precorrin-5A with a K-cluster phosphatase diester AMP hydroxycarboxylate precorrin-8x thiamine diphosphate salvage II aminotransferase: pyruvate CoA (2Fe-2S)] complex CobZ: cobZ (R)-4'- dipyrromethane 4-aminobenzoate oxaloacetate [+ 2 isozymes] cobalt- MCON_RS09795 aldehydo-D-ribose D-glyceraldehyde phosphodiesterase: α α phosphopantothenate cofactor biosynthesis gln precorrin 5A precorrin-8X Co -[ -(adenin-7-yl)]- MCON_RS02480 + 4-amino-2-methyl-5- 5-phosphate 3-phosphate phosphoenolpyruvate a formylmethanofuran THMPT NAD menadiol methylmutase: 3-sulfopyruvate Coβ-adenosylcobamide sn-glycerol hydrolase: pyrimidinemethanol an apo-[hydroxymethylbilane synthase: ppsA 5-methyl- an oxidized 3-phosphate cbiG a [co-chaperone]- MCON_RS02820 bifunctional a NifB protein sulfopyruvate synthase]-L-cysteine pyridoxal 5'- tetrahydrosarcinapterin factor 420 [scaffold protein- precorrin-8X formylmethanofuran-- 6 cobalt- hydroxymethylpyrimidine with an L-cluster decarboxylase: phosphate phosphoenol an N -L- D-ribulose an N-terminal- (2Fe-2S)] complex tetrahydromethanopterin 3'-dephospho- an (S)-2- a myo-inositol a D-aspartyl- precorrin-5B methylmutase: bis(guanylyl molybdopterin) synthase: a sulfurated threonylcarbamoyladenine 37 glycerophosphoserine L-methionyl-L- H O methylarsonite sec formate SSQ1 kinase/ nitrogenase comD comE a [hydroxymethylbilane pyruvate Inorganic Nutrient CoA halocarboxylate 5-phosphate 2 asp ser a tRNA UTP MCON_RS07220 N-formyltransferase: fhcD [sulfur carrier] ATP GTP monophosphate [tRNA ] XTP cobalt-precorrin- phosphomethylpyrimidine cofactor sulfurylation synthase] ES intermediate pdxT pdxS Metabolism in tRNA cysteinyl-[protein] arsenite chaperone: iron- 2 phosphopyruvate DHAP bifunctional 5B (C(1))- kinase: MCON_RS07260 sulfoacetaldehyde coenzyme A biosynthesis Amine and Polyamine methyltransferase: dnaK hydrogenobyrinate molybdenum hydroxymethylbilane hydratase: eno 5,10-methylene- fructose- XTP/dITP I (prokaryotic) nitrogen HAD family bifunctional glycerophosphoryl MCON_RS12800 anaerobic methyltransferase: a [chaperone-ATP]- cofactor 2-oxoglutarate cys Biosynthesis tetrahydrosarcinapterin 5-formyl-tetrahydromethanopterin type II methionyl bisphosphatase/ D-aminoacyl- serine-- diphosphatase: bifunctional synthase: hemC PLP tRNA (N(6)-L- hydrolase: 3,4-dihydroxy- diester GTPase ribonucleoside- MCON_RS07215 [co-chaperone]- hydrogenobyrinate 2-phospho- fixation I triphosphoribosyl- aminopeptidase: arsenite tRNA deacylase: hydroxymethylpyrimidine biosynthesis (R)-4'- threonylcarbamoyladenosine(37) HflX: hflX inositol-phosphate tRNA ligase: MCON_RS03990 homocitrate cysteine a [hydroxymethylbilane ectoine biosynthesis D-glycerate methenyltetrahydromethanopterin (ferredoxin) MCON_RS07050 2-butanone- phosphodiesterase: triphosphate cobalt- [scaffold protein- a,c-diamide kinase/ protein phosphopantothenate -C(2))- methylthiotransferase: dephospho- MCON_RS08225 methyltransferase: phosphatase: MCON_RS00630 MCON_RS08970 synthase: desulfurase: 2-(sulfomethyl) bifunctional synthase] ES intermediate cyclohydrolase: MCON_RS05530 HAD family 4-phosphate MCON_RS02480 [+ 2 isozymes] reductase: nrdD precorrin-6A (2Fe-2S)] complex synthase: cfbB phosphomethylpyrimidine NifE: nifE 3 cofactor- N MCON_RS02435 CoA synthase: arsM MCON_RS08890 XMP thiazolidine- 2 synthase/GTP aksA MCON_RS11720 phosphopantothenoylcysteine independent 5,10-methenyl- MCON_RS00290 hydrolase: hydrogenobyrinate kinase: thiD a NifEN protein hydroxymethylbilane asp nitrogenase dimethylarsonite myo-inositol SSQ1 4-carboxylate decarboxylase/ 5,10-methenyltetrahydromethanopterin MCON_RS11655 cyclohydrolase II: an N-terminal L- H + an L-seryl- a,c-diamide complex containing cysteine synthase: hemC phosphoglycerate tetrahydrosarcinapterin molybdenum- 6 sn-glycerol phosphate tRNA asp dUTP (2R)-homocitrate bis(guanylyl tungstenpterin) a 2-methylsulfanyl-N -L- MCON_RS04985 met cysteinyl-[protein] GDP D-aspartate sec chaperone phosphopantothenate-- aspartate kinase: mutase: ser [tRNA ] putative HMP-P an L-cluster desulfurase methenyltetrahydromethanopterin iron protein: threonylcarbamoyladenine 37 5'-deoxyadenosine an unsulfurated 2'-(5''-triphospho- 3-phosphate cysteine ligase CoaBC: coaBC molybdopterin biosynthesis a [hydroxymethylbilane cofactor biosynthesis MCON_RS07085 met cobalt- ATPase: dnaK NifS: nifS (R)-4'- MCON_RS06185 nifD nifK [sulfur carrier] α-D-ribosyl)-3'- a (2R)-2- cobaltochelatase: synthase] ES intermediate cyclohydrolase: MCON_RS05530 in tRNA adenine precorrin-6B bifunctional an [L-cysteine phosphopantothenoyl- 4 L-aspartyl- a halide anion 1-deoxy-L- MCON_RS02905 molybdenum 2,3-bisphosphoglycerate- ammonium dephospho-CoA hydroxy fatty acid a [chaperone- hydroxymethylpyrimidine desulfurase]-S- L-cysteine hydroxymethylbilane 4-phosphate 5-formyl- glycero-tetrulose formate cobalt-precorrin- an [2Fe-2S] chelatase: cfbC sulfoethylcysteine GTP independent a methanofuran ADP]-[disordered- [+ 4 isozymes] cys bis(tungstenpterin) tetrahydrosarcinapterin 5,10-methylene-tetrahydromethanopterin a reduced factor 420 15 kinase/ sulfanyl-L-cysteine bifunctional synthase: hemC CO 4-phosphate 6B (C )- cluster protein cofactor aspartate- phosphoglycerate 2 form scaffold cob(II)yrinate a NifEN protein cysteine ATP methyltransferase phosphomethylpyrimidine phosphopantothenoylcysteine a holo-[hydroxymethylbilane a,c-diamide cysteine GTP semialdehyde mutase: formylmethanofuran-- protein] complex kinase: MCON_RS07260 complex containing desulfurase: decarboxylase/ CO dehydrogenase/ 5,10-methylenetetrahydromethanopterin [decarboxylating]: desulfurase: synthase] molybdenum cofactor dehydrogenase: MCON_RS11575 7,8-didemethyl- 3-(D-glyceryl) sn-glycero-3- 1-deoxy-L- 3''-O-acetyl- an N-terminal- non- an M-cluster MCON_RS11720 tetrahydromethanopterin acetyl-CoA synthase reductase: mer an (R)-2- arsenic a D-tryptophanyl- MCON_RS07245 bifunctional phosphopantothenate-- 8-hydroxy-5- -diphospho- glycero-tetrulose ADP-ribose superoxide L-methionyl-L- formate F6P bis(guanylyl MCON_RS11720 guanylyltransferase: asd 3-phospho- N-formyltransferase: fhcD halocarboxylate triglutathione phosphoethanolamine Trp ARP CTP ITP chaperonin 5-(2-hydroxyethyl) cysteine coenzyme M cysteine ligase CoaBC: coaBC GTP 3',8- factor 420 ATP biosynthesis complex subunit dGTP [tRNA ] hydroxymethylpyrimidine MCON_RS00955 deazariboflavin 5'-guanosine 4-phosphate valyl-[protein] glutamine-- molecular -4-methylthiazole molybdopterin) cysteine cyclase polyglutamylation L-aspartate 4- D-glycerate epsilon: cdhA cobalt-precorrin-7 kinase/ desulfurase 5 fructose-6- cofactor desulfurase a carboxy- N -methyltetrahydromethanopterin O-acetyl-ADP- XTP/dITP chaperone NifS: nifS 4'-phosphopantetheine MoaA: semialdehyde phosphoglycerate anaerobic HAD family arsenite glycerophosphoryl superoxide anaerobic thiamine diphosphate phosphomethylpyrimidine hydroxyethylthiazole adenylated oxidized bis(guanylyl a formylmethanofuran ADP 2-phospho-L- D-aminoacyl- type II methionyl phosphate cobalt-precorrin- ATPase: dnaK a NifDK protein NifS: nifS moaA Fatty Acid and diester 6,7-dimethyl-8- ribose deacetylase: dismutase: diphosphatase: kinase: thiD kinase: thiM a [bis(guanylyl diaminobutyrate- kinase: pgk carbon-monoxide hydrolase: methyltransferase: ribonucleoside- transaminase 7 (C(5))- an [Fe-S cluster biosynthesis phosphopantetheine an [L-cysteine [small subunit of factor 420-0 tungstenpterin) cofactor ATP synthase Lipid Degradation lactate transferase: dNTP tRNA deacylase: ribityllumazine MCON_RS13165 aminopeptidase: MCON_RS03990 containing an M-cluster molybdopterin) (8S)-3',8-cyclo-7,8- coenzyme -2-oxoglutarate formylmethanofuran dehydrogenase MCON_RS07050 MCON_RS12800 phosphodiesterase: MCON_RS11090 triphosphate II (Bacillus) adenylyltransferase: desulfurase]-S- molybdopterin MCON_RS04600 MCON_RS00630 MCON_RS08225 (isomerizing) methyltransferase: biosynthesis 4-methyl-5-(2- dihydroguanosine F420-0:L- archaeal: triphosphohydrolase: dgt MCON_RS02480 synthase: HMP-PP cofactor [bis-MGD cofactor transaminase: ectB 13-DPG dehydrogenase: catalytic subunit: cooS triacylglycerol HAD family arsenite reductase: nrdD : glmS MCON_RS07210 chaperone]-ATP phosphooxyethyl)thiazole MCON_RS06385 sulfanyl-L-cysteine synthase] MCON_RS10660 MCON_RS09790 IMP Zn 2+ RS05805 Zn 2+ HMP-PP chaperone]-S- chaperone]- 5'-triphosphate glutamate ligase: MCON_RS04115 D-glucosamine L-2,4- triose- a [methyl-Co(III) corrinoid Fe-S protein] degradation hydrolase: methyltransferase: acetate ADP-D-ribose hydrogen thiamine 3'-dephospho- cyclic pyranopterin MCON_RS03955 MCON_RS10665 CO O sulfanyl-L-cysteine bis-MGD [+ 2 isozymes] oxidized 3PG- MCON_RS11655 arsM 2 an N-terminal 6-phosphate cobalt-precorrin-8 diaminobutanoate phosphate Trp peroxide dCTP phosphate thiamine CoA monophosphate MCON_RS10670 a triacyl-sn ethanolamine sn-glycerol D-tryptophan a tRNA met coenzyme isomerase: factor 420-0 GMP triphosphate 6,7-dimethyl-8-(1- L-valyl-[protein] synthase: phosphate synthase diaminobutyrate CO MCON_RS10675 -glycerol 2'-deoxyguanosine 3-phosphate cobalt-precorrin- formate F420-0:L- tpiA 2 D-ribityl)lumazine synthase: thiE a thiocarboxylated MoaC: moaC D-glyceraldehyde MCON_RS10680 CO dehydrogenase/ a (2R)-2- Zn 2+ RS14495 Zn 2+ 8 methylmutase: S-adenosyl- thiE dehydrogenase glutamate acetyltransferase: DHAP tributyrin esterase: a halide anion dimethylarsonite glutathione thiamine [small subunit of cyclic 3-phosphate MCON_RS10685 CO-methylating acetyl- hydroxy fatty acid MCON_RS07220 L-methionine NADP accessory ligase: cofE ectA MCON_RS05045 phosphate molybdopterin pyranopterin MCON_RS10695 CoA synthase complex: sulfurtransferase coenzyme A oxidized biosynthesis thiamine phosphate biosynthesis synthase] phosphate (2S)-4-acetamido- MCON_RS05680 cdhC cobyrinate thiamine- factor 420-1 ahaH a 1,2-diacyl- FdhD: fdhD 2-aminobutanoate β 7,8-didemethyl- enolpyruvoyl- (1S,2R)-1- an N-terminal- 2''-O-acetyl- dTDP- -L-rhamnose 2-oxoisovalerate decarboxylation to isobutanoyl-CoA sn-glycerol hydrogen 2+ 2+ met phosphate + F420-1:γ- CO dehydrogenase/ a tRNA precursor with a 5' a D-aminoacyl- 2-iminosuccinate carbonic acid Zn RS09145 Zn thiamine- NAD 8-hydroxy-5- 2-diphospho- C-(indol-3- pyruvate L-methionyl-L- asp O-ureido-L- Ins(5)P ADP-ribose DHAP cobyrinate A,C- ectoine synthase: class II fructose- biosynthesis ATP ser [tRNA] peroxide GTP methionine kinase: thiL sulfo-bis(guanylyl glutamyl ligase: CO-methylating acetyl- extension and a short 3' extension homoserine diamide synthase: phosphate NAD(+)/ an [apo BCAA deazariboflavin 5'-guanosine yl)glycerol threonyl-[protein] bifunctional fructose- adenosyltransferase: molybdopterin) MCON_RS03955 MCON_RS05170 bisphosphate α-D-glucopyranose CoA synthase complex thiamine kinase: thiL NADH kinase: dehydrogenase 3-phosphate anaerobic MCON_RS12610 MCON_RS12000 aldolase: 1-phosphate subunit beta: cdhC bisphosphatase/ O-acetyl-ADP- quinolinate carbonate diphosphate MCON_RS08895 cofactor molybdopterin oxidized E2 protein] N 6 pyruvate ferredoxin catalase: ribonucleoside- ectoine MCON_RS10715 glucose-1-phosphate 3-methyl-2- 2-phospho-L- ribonuclease P D-aminoacyl- type II methionyl argininosuccinate inositol-phosphate ribose deacetylase: 2+ 2+ cob(II)yrinate SAM thiamine diphosphate + a 2-acylglycerol oxidoreductase synthase dehydratase: triphosphate Zn ZupT Zn NADP factor 420-2 -lipoyl-L-lysine oxobutanoate lactate transferase: tryptophan tRNA deacylase: aminopeptidase: synthase: MCON_RS00675 a,c-diamide thymidylyltransferase: protein component phosphatase: MCON_RS13165 NadA: nadA MCON_RS05210 3-methyl-2- synthase: subunit gamma: reductase: nrdD MCON_RS11015 dehydrogenase acetyl-CoA MCON_RS04600 1: MCON_RS11460 MCON_RS00630 MCON_RS08225 MCON_RS14155 MCON_RS08890 dTDP-α-D-glucose oxobutanoate MCON_RS07760 MCON_RS06265 subunit VorB: myo-inositol dGTP dehydrogenase [+ 2 isozymes] β MCON_RS03355 reductive TCA cycle I trpB [+ 2 isozymes] acetate ADP-D-ribose O H O -D-fructose 1,6- dTDP-glucose 4,6- quinolinate CO H O 2 2 subunit VorB: dehydro an N-terminal L- 2 2 sulfite RS00160 sulfite Secondary Metabolite Biosynthesis an uncharged canavaninosuccinate gln bisphosphate dehydratase: rfbB a D-amino acid met glutaminyl-tRNA Aminoacyl-tRNA Charging MCON_RS03355 a fatty acid glycerol factor 420-0 GMP D-glyceraldehyde tRNA threonyl-[protein] dTDP-4-dehydro-6- a tRNA precursor with biosynthesis via transamidation fructose-1,6- 2-oxoglutarate a tRNA fragment 3-phosphate trp acetyl-CoA CO a reduced dihydrolipoyl a short 3' extension 2 preQ biosynthesis bisphosphatase: deoxy-α-D-glucopyranose flavodoxin 0 myo-inositol dehydrogenase:an [apo BCAA an [apo BCAA dehydrogenase MCON_RS10710 dTDP-4- sulfite RS05910 sulfite glu biosynthesis MCON_RS02315dehydrogenase E2 protein] N 6 -S-[2- [+ 2 isozymes] dehydrorhamnose 6 E2 protein] N - methylpropanoyl]dihydrolipoyl- Detoxification D-glucopyranose a [ThiI sulfur- all-trans- an sn-glycero-3- 6 GTP 3,5-epimerase: an N-modified a [histone]-N - a [protein]-L- a double a supercoiled dihydrolipoyl-L-lysine L-lysine MoO - a uracil in tRNA sn-glycerol a RNA-DNA hybrid Ins(4)P 6-phosphate F6P MCON_RS11000 2 carrier protein]- heptaprenyl phospho-N-(acyl) stranded DNA duplex DNA met GTP inositol-3- GTP 1-phosphate aminoacyl-[tRNA] acetyl-L-lysine methionine ATP molybdopterin diphosphate ethanolamine bifunctional DNA: ATP-dependent + + cyclohydrolase dTDP-4-dehydro- succinyl-CoA D-threo-isocitrate arsenate molybdopterin S-sulfanyl- bifunctional fructose- bifunctional Na RS11175 Na phosphate glucose-6- cofactor anaerobic β-L-rhamnose detoxification L-cysteine methionine gyrB gyrA DNA helicase: an L-glutamyl- I FolE2: synthase: bisphosphatase/ ornithine phosphate histone ribonuclease HII: sulfoxide reductase MCON_RS02375 ribonucleoside- gln [tRNA Gln ] 7,8- MCON_RS13980 dTDP-4- II (glutaredoxin) geranylgeranylglyceryl/ glycerophosphoryl peptidyl-tRNA inositol-phosphate DNA acetyltransferase/ MCON_RS00115 isomerase: tRNA 4- deacetylase: triphosphate dihydroneopterin 3-methyl-2- molybdenum cofactor heptaprenylglyceryl diester hydrolase: MCON_RS10630 phosphatase: B/A protein: topoisomerase: ATP-dependent Ins(3)P MCON_RS12640 dehydrorhamnose aconitate hydratase: arsenate MCON_RS02520 N-acetylglutamate Asp-tRNA(Asn) 3'-triphosphate oxobutanoate guanylyltransferase: thiouridine(8) MCON_RS02260 reductase: nrdD + + Asp-tRNA(Asn) reductase: rfbD MCON_RS01420 arsenate phosphate synthase: phosphodiesterase: MCON_RS13430 MCON_RS08890 a protein-L- MCON_RS06610 DNA helicase: synthase: argJ Na OadA Na /Glu-tRNA(Gln) D-glucopyranose dehydrogenase succinyl-CoA synthetase: MCON_RS00955 synthase [+ 3 isozymes] /Glu-tRNA(Gln) 6-carboxytetrahydropterin reductase ArsC: MCON_RS08235 MCON_RS02480 myo-inositol methionine- MCON_RS06615 MCON_RS10275 N-acetyl-L- dATP amidotransferase: bifunctional 6-phosphate dTDP-β-L-rhamnose subunit VorB: ThiI: thiI a nucleoside 5'- a negatively a single amidotransferase: synthase QueD: queD MCON_RS01900 MCON_RS12825 DNA methionine fructose- succinate cis-aconitate (S)-S-oxide gatC gatA gatB MCON_RS03355 bis(guanylyl an N-modified an uncharged monophosphate supercoiled DNA stranded DNA gatC gatA gatB arsenite a [ThiI sulfur- 3-heptaprenyl- [+ 2 isozymes] 6-carboxy-5,6,7,8- bisphosphatase/ a 4-thiouracil sn-glycerol an N- amino acid tRNA acetate a [histone]-L-lysine molybdopterin) sn-glycero- arsenite RS14530 arsenite [+ 13 isozymes] a 5-phosphooxy- tetrahydropterin inositol-phosphate carrier protein]- in tRNA acylethanolamine cofactor 3-phosphate phosphatase: Aromatic Compound Biosynthesis L-cysteine 1-phosphate ammonium L-glutamyl- 7-carboxy-7- Tetrapyrrole Biosynthesis aconitate hydratase: [tRNA Gln ] deazaguanine MCON_RS08890 MCON_RS01420 chorismate biosynthesis II (archaea) 2,5-diamino-6-(5- a protein-L- 5-deoxy-α- synthase QueE: tetrapyrrole biosynthesis arsenite a 2-oxo a [protein]- a triacyl-sn arsenite ArsB arsenite myo-inositol H O a [protein]-L-lysine an L-glutamyl- Asp-tRNA(Asn) MCON_RS14985 I (from glutamate) diphosphate 2 phospho-D-ribosylamino) a protein Ins(2)P methionine- 5-MTR-1-P D-ribose 1- fumarate citrate carboxylate ATP L-glutamine -glycerol [tRNA Gln ] XMP /Glu-tRNA(Gln) D-glyceraldehyde a tRNA precursor pyrimidin-4(3H)-one (R)-S-oxide phosphate 7-carboxy-7- 2,5-diamino-6- archaeal proteasome bifunctional fructose- bifunctional Asp-tRNA(Asn) S-methyl-5- S-methyl-5- amidotransferase: 3-phosphate CTP deazaguanine glu Macromolecule Modification (ribosylamino)- endopeptidase complex bisphosphatase/ methionine /Glu-tRNA(Gln) thioribose-1- thioribose-1- 5'/3'- gatC gatA gatB fumarate hydratase: ATP citrate synthase: 2-oxoacid:ferredoxin transglutaminase nitrite nitrite Ni 2+ RS09640 Ni 2+ glutamate-- manganese- 4(3H)-pyrimidinone subunit beta: psmB tributyrin esterase: inositol-phosphate phosphate phosphate nucleotidase RS11645 7-cyano-7- asp MCON_RS12620 oxidoreductase domain-containing sulfoxide reductase amidotransferase: [+ 2 isozymes] MCON_RS01900 dependent inorganic CCA tRNA MCON_RS05045 isomerase: formate formate deazaguanine tRNA ligase: N 6 -L-threonylcarbamoyladenosine 37 subunit beta: 5'-phosphate archaeal proteasome phosphatase: B/A protein: gatC gatA gatB isomerase: SurE: surE pyrophosphatase: nucleotidyltransferase: protein: synthase MCON_RS00605 archaeosine reductase: endopeptidase complex MCON_RS08890 MCON_RS02260 MCON_RS14595 MCON_RS14595 aspartate kinase: an L-glutamyl- -modified tRNA biosynthesis MCON_RS11295 MCON_RS15300 [+ 2 isozymes] S-methyl-5- 5-deoxy-D- an L-glutaminyl- enolaldehyde biosynthesis I MCON_RS08190 MCON_RS04965 a [protein]-L- an L-glutaminyl- xanthosine QueC: queC Glu (S)-malate acetyl-CoA 2,5-diamino-6-(5-MCON_RS00730 subunit alpha: psmA myo-inositol thio-D-ribulose ribulose 1- MCON_RS07085 [tRNA ] a diacyl-sn Gln 2+ 2+ Gln pyruvate ferredoxin methionine [tRNA ] 2+ 2+ Ca RS07715 Ca [tRNA ] phospho-D-ribitylamino) a fatty acid 1-phosphate phosphate Co CbiQ Co thr a reduced a protein with an a peptide -glycerol preQ preQ oxidoreductase subunit + 0 glutamyl-tRNA 0 a tRNA an acyl-CoA CO H + 6 pyrimidin-4(3H)-one L-aspartyl- 2 γ reductase: threonylcarbamoyl- tRNA NAD-dependent malic gamma: MCON_RS06265 ferredoxin [iron- phosphate H containing a N -( -glutamyl)- tRNA charging 4-phosphate β-D-fructose 1,6- MCON_RS06425 AMP synthase: guanosine(15) enzyme 4: MCON_RS08245 [+ 2 isozymes] sulfur] cluster 3' CCA end L-lysine crosslink methylglyoxal MCON_RS02535 Co 2+ Co 2+ an anion RS00450 an anion bisphosphate aspartate- (S)-4-amino-5- (L-threonylcarbamoyl) transglycosylase CorA Mg 2+ Mg 2+ phe a tRNA Phe a tRNA Ala ala semialdehyde oxopentanoate adenylate preQ atTgtA: tgtA elongator 0 a CDP- hydrogen 2,5-diamino-6-(5- 6,7-dimethyl-8-(1- a uridine 54 (2R,3S)-3- a supercoiled glu Tyr Arg Thr Ile asp Gly ser Pro His Trp Leu Met position 15 of oxaloacetate pyruvate fluoride a reduced a ribonucleoside a single L(or D)-O- glu a tRNA tyr a tRNA arg a tRNA thr a tRNA ile a tRNA tRNA asp gly a tRNA ser a tRNA pro a tRNA his a tRNA trp a tRNA leu a tRNA Met met initiator tRNA met dehydrogenase: bifunctional N(6)-L- ser SAM phospho-D-ribosylamino) canavaninosuccinate Ins(6)P tRNA glutamate-1- phosphoenolpyruvate diacylglycerol peroxide D-ribityl)lumazine in tRNA isopropylmalate duplex DNA IMP Val Lys an archaeal tRNA thioredoxin triphosphate stranded DNA phosphoserine val a tRNA lys a tRNA asd semialdehyde threonylcarbamoyladenine pyrimidin-4(3H)-one tRNA 3-isopropylmalate ATP-dependent Asn Cys Gln synthase: ppsA 2,5-diamino-6- bifunctional fructose- chloride RS12460 chloride phenylalanine- alanine- asn tRNA cys a tRNA gln a tRNA 6-deoxy-5- archaeosine phosphoserine Mg 2+ RS12045 Mg 2+ L-aspartate 4- 2,1- synthase/serine/ pseudouridine(54/ dehydratase helicase: -tRNA ligase: glutamate-- tyrosine-- arginine-- threonine-- isoleucine-- aspartate-- glycine- -tRNA serine-- proline-- histidine-- tryptophan-- leucine- methionine- methionine- synthase: (ribosylamino)- bisphosphatase/ 5'/3'- ketofructose threonine protein SAM-dependent peroxiredoxin: argininosuccinate riboflavin synthase: 55) synthase MCON_RS03080 phosphatase semialdehyde aminomutase: CDP-diacylglycerol--serine DNA primase 4(3H)-pyrimidinone inositol-phosphate small subunit: nucleotidase MCON_RS08465 tRNA ligase: tRNA ligase: valine--tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA(Asn) lysine--tRNA ligase: -tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA -tRNA 1-phosphate MCON_RS01405 SerB: serB hemL kinase: MCON_RS08040 archaeosine at O-phosphatidyltransferase: chlorinase/ MCON_RS07585 large subunit PriL: lyase: argH MCON_RS06990 phosphatase: Pus10: MCON_RS08260 helicase: SurE: surE MCON_RS08470 MCON_RS00605 MCON_RS00960 MCON_RS05100 MCON_RS05970 MCON_RS06030 ligase: aspS ligase: glyS alaS MCON_RS08970 MCON_RS09025 MCON_RS09050 MCON_RS09080 ligase: leuS ligase: metG ligase: metG 6 5'-phosphate MCON_RS05000 MCON_RS08360 an N -L- fluorinase: MCON_RS11680 position 15 of pssA peroxiredoxin: MCON_RS06460 reductase: MCON_RS08890 [+ 3 isozymes] MCON_RS11360 serine a metal a metal 5-aminolevulinate threonylcarbamoyladenine 37 phosphoenolpyruvate MCON_RS10170 a pseudouridine 54 (2S)-2- a single RS07705 an L-methionyl- an archaeal tRNA formate oxidation to CO MCON_RS11095 [+ 2 isozymes] MCON_RS00730 myo-inositol inosine cation cation an L-phenylalanyl- an L-glutamyl- an L-tyrosyl- an L-valyl- an L-arginyl- an L-threonyl- an L-isoleucyl- an L-aspartyl- an L-lysyl- an L-alanyl- an L-seryl- an L-prolyl- an L-histidyl- an L-tryptophanyl- an L-leucyl- an L-methionyl- an L-asparaginyl- an L-cysteinyl- an L-glutaminyl- in tRNA 2 2,5-diamino-6-(5- in tRNA isopropylmalate stranded DNA a glycyl-[tRNA Gly ] [elongator a 3-sn- L-canavanine fumarate ARP riboflavin [tRNA Phe ] [tRNA Glu ] [tRNA Tyr ] [tRNA Val ] [tRNA Arg ] [tRNA Thr ] [tRNA Ile ] [tRNA asp ] [tRNA Lys ] [tRNA Ala ] [tRNA ser ] [tRNA Pro ] [tRNA His ] [tRNA Trp ] [tRNA Leu ] [initiator tRNA Met ] [tRNA Asn ] [tRNA Cys ] [tRNA Gln ] 2-amino-3,7- porphobilinogen CMP phospho-D-ribitylamino) tRNA Met ] phosphatidyl- 5'-deoxy-5'- dideoxy-D-threo- synthase: hemB formate met an oxidized H O ssDNA/pppN(pN) pyrimidin-4(3H)-one L-serine fluoroadenosine 2 a metal a metal hept-6-ulosonate formate dehydrogenase thioredoxin hybrid RS00660 Pentose Phosphate Pathways Amino Acid Degradation n -1 cation cation 3-dehydroquinate porphobilinogen subunit alpha: fdhF synthase II: formate dehydrogenase Glycolysis pentose phosphate pathway a [lipoyl-carrier Amino Acid Biosynthesis MCON_RS05335 hydroxymethylbilane L-methionine degradation a [sulfatase]- a 2'-deoxyribonucleoside a ribonucleoside an L-aspartyl- succinate β-D-glucose a reduced subunit alpha: fdhF L-glutamine (R)-mevalonate glycerophosphoglycerol A ammonium H O tributyrin 6 (oxidative branch) II L-citrulline degradation SAM 2 Ins(1)P protein]-N -[(R) a metal a metal synthase: hemC CO I (to L-homocysteine) L-cysteine 5'-triphosphate [DNA] diphosphate [tRNA Asn ] semialdehyde 6-phosphate factor 420 RS01275 3-dehydroquinate 2 degradation II glycolysis I (from glucose 6-phosphate) adenosylcobalamin- bifunctional fructose- Asp-tRNA(Asn) -dihydrolipoyl]- NAD-dependent inositol-3- NADPH- cation cation L-histidine biosynthesis L-asparagine biosynthesis III (tRNA-dependent) preuroporphyrinogen F6P L-lysine succinate- phosphate dependent L-lysine biosynthesis VI L-leucine biosynthesis L-isoleucine L-serine biosynthesis I dependent bisphosphatase/ /Glu-tRNA(Gln) dihydrolipoyl L-arginine biosynthesis I (via L-ornithine) type I 3- D-glucopyranose met L-citrulline anaerobic hydroxymethylglutaryl- glycerophosphoryl gln DNA polymerase/ ribonucleoside- hydroxylamine tributyrin esterase: inositol-phosphate amidotransferase: semialdehyde synthase: F420 biosynthesis IV dehydroquinate methionine ornithine CoA reductase, diester dehydrogenase: PRPP 3-phospho- 6-phosphate NADPH- sulfatase maturase: 3'-5' exonuclease reductase: hcp MCON_RS05045 dehydrogenase: MCON_RS00115 reductase: a metal a metal 3-methyl-2- adenosyltransferase: carbamoyltransferase: diphosphate phosphatase: gatC gatA gatB MCON_RS02315 RS06795 asp dehydratase: MCON_RS11610 degradative: phosphodiesterase: an L-asparaginyl- a [lipoyl-carrier cation cation glu asp oxobutanoate propanoate D-glycerate dependent PolX: polX reductase: MCON_RS08890 MCON_RS11705 npdG phosphoglycerate MCON_RS05340 glucose-6- MCON_RS12000 argF MCON_RS11225 MCON_RS02480 Asn 6 Ins(3)P ATP 2-isopropylmalate carbamoyl glutamate [tRNA ] protein]-N -[(R an oxidized aspartate kinase: dehydrogenase: phosphate hexulose 6- SAM [+ 5 isozymes] MCON_RS07100 myo-inositol succinate phosphoribosyltransferase: aspartate-- synthase: uroporphyrinogen-III a 2'- )-lipoyl]-L-lysine factor 420 bifunctional 3-dehydroshikimate phosphate synthase: a [sulfatase]-3- hydroxylamine butanoate 1,2-dibutyrin tRNA(Asn) MCON_RS07085 MCON_RS14235 isomerase: phosphate 5'-deoxyadenosine deoxyribonucleoside MCON_RS08090 MCON_RS10545 gltA met oxo-L-alanine a metal a metal ornithine L-aspartyl- 3-phosphooxypyruvate MCON_RS12640 carbamate kinase: + glycerol sn-glycerol RS06810 ligase: aspS [+ 2 isozymes] propanoyl-CoA HMG-CoA NADH H 5'-diphosphate 1-(5-phospho- acetyltransferase/ (2S)-2- shikimate glu [DNA] 3-phosphate cation cation gln 4-phosphate bifunctional 5,6,7,8- MCON_RS09555 β-D-ribosyl)-ATP N-acetylglutamate an L-aspartyl- isopropylmalate 3-phosphoserine dehydrogenase: 2-oxoacid:ferredoxin F6P tetrahydromethanopterin [+ 2 isozymes] synthase: argJ [tRNA Asn ] aspartate- aminotransferase: aroE 3-isopropylmalate oxidoreductase hydro-lyase/3-hexulose- Asp-tRNA(Asn) semialdehyde MCON_RS10635 SAH carbamate an N-terminal L- an [amino-group carrier a metal a metal Asp-tRNA(Asn) subunit beta: a ribonucleoside a negatively RS06835 N-acetyl-L- /Glu-tRNA(Gln) dehydratase shikimate fructose-1,6- 6-phosphate synthase: a tetrahydrofolate a 2'-deoxyribonucleoside carbamoyl a uracil in DNA hydantoin L-threonine 3- dehydrogenase: ser [DNA] a tRNA precursor L-ornithine alanyl-[S18 protein protein]-C-terminal-γ- supercoiled DNA IPP arg cation cation β glutamate /Glu-tRNA(Gln) large subunit: MCON_RS11295 O-phospho- MCON_RS05920 5'-triphosphate triphosphate 1-(5-phospho- - amidotransferase: asd bisphosphatase: adenosylhomocysteinase: L-alanine phosphate of 30S ribosome] (L-glutamyl)-L-glutamate DNA O-phosphate amidotransferase: MCON_RS01895 L-serine shikimate kinase: ribosomal protein anaerobic type 2 isopentenyl- biosynthetic D-ribosyl)-AMP gatC gatA gatB 2-oxobutanoate MCON_RS10710 MCON_RS12410 degradation IV hydantoinase: topoisomerase I: threonine- acetylglutamate gatC gatA gatB L-aspartate 4- MCON_RS01525 S18-alanine N- acetylglutamate ribonucleoside- diphosphate arginine phosphoribosyl- [+ 13 isozymes] [+ 3 isozymes] phosphoserine D-ribulose uracil-DNA MCON_RS09870 phosphate a metal a metal a 4-phosphooxy- semialdehyde uracil degradation [+ 2 isozymes] formaldehyde serine DNA polymerase/ ornithine acetyltransferase: kinase: argB triphosphate MCON_RS03290 Delta-isomerase: kinase: argB acetolactate shikimate kinase: 5-phosphate CO ribonuclease Z: glycosylase: decarboxylase: decarboxylase: RS03000 AMP phosphatase L-homocysteine 2 cation cation L-aspartyl- 2-isopropylmaleate I (reductive) MCON_RS11250 ala hydroxymethyltransferase: 3'-5' exonuclease carbamoyltransferase: an N-terminal N-acetyl-rimI an [amino-group carrier a 2'- reductase: nrdD [+ 2 isozymes] MCON_RS10845 speA ammonium 4-hydroxy- synthase: SerB: serB β-D-fructose 1,6- MCON_RS13620 MCON_RS05650 (R)-1-amino-MCON_RS05710 cyclohydrolase: N-acetylglutamyl- [tRNA Asn ] diphthamide DHAP MCON_RS00940 PolX: polX argF N-carbamoylglycine a relaxed DNA tetrahydrodipicolinate alanine L-alanyl-[S18 protein protein]-C-terminal- deoxyribonucleoside DMAPP agmatine hisI phosphate 3-isopropylmalate MCON_RS01755 uracil shikimate 3- bisphosphate 2-propanol O biosynthesis I (archaea) dehydrogenase: [+ 5 isozymes] of 30S ribosome] γ-(5-phospho-L- 5'-triphosphate 1-(5-phospho-β-D-ribosyl)- synthase: ilvN ser phosphate -2-phosphate N-acetyl-gamma- Asp-tRNA(Asn) dehydratase class II fructose- a 5,10- an apyrimidinic uracil a metal a metal MCON_RS03460 an L-histidine- MCON_RS03905 a single-stranded glutamyl)-L-glutamate RS03860 5-[(5-phosphoribosylamino) /Glu-tRNA(Gln) large subunit: (S)-2-aceto-2- 3-phosphoshikimate 1- bisphosphate NADH repair (prokaryotes) gly methylenetetrahydrofolate site in DNA cation cation glutamyl-phosphate (2S,4S)-4- [translation triose- pyruvate mature tRNA oligoribonucleotide L-citrulline methylideneamino]imidazole- amidotransferase: MCON_RS01895 hydroxybutanoate 5,6-dihydrouracil carboxyvinyltransferase: aldolase: [DNA] hydrogencarbonate reductase: hydroxy-2,3,4,5- elongation factordiphthamide 2] phosphate 4-carboxamide gatC gatA gatB 2-aceto-2-hydroxy- aroA MCON_RS10715 MCON_RS06195 tetrahydrodipicolinate [+ 3 isozymes] biosynthesis isomerase: NADH 1-(5-phosphoribosyl)-5- glutamine- N-acetyl-L- butanoate hydantoinase: 5-enolpyruvoyl- 4-hydroxy- (2R,3S)-3- enzyme tpiA thiol CydC thiol [(5- phosphoribosylamino) hydrolyzing MCON_RS09870 shikimate 3- 2-[(2R,5Z)-2-carboxy- glutamate 5- an L-asparaginyl- tetrahydrodipicolinate isopropylmalate isomeroreductase: a 2-[(3S)-3-amino- a single D-ribulose-1,5- a dietary all- a 3,5,7,9,11,13,15- an [RNA]-3'- a uridine 38- a cytidine DNA containing γ-glutamyl- Dph2: dph2 histidinol acetylene methylideneamino]imidazole- carbamoyl- semialdehyde Asn ilvC phosphate 4-methylthiazol-5(2H)- ribonucleoside- 56 [tRNA ] reductase: 3-isopropylmalate 3-carboxypropyl]-L- D-glyceraldehyde stranded DNA ATP HMP-PP bisphosphate trans-retinyl ester hepta-oxo- 40 in tRNA in tRNA a recognition site isopropylamide 4- carboxamide isomerase: phosphate acetylornithine 3-ureidopropanoate chorismate ylidene]ethyl phosphate 2',3'- tRNA tRNA (cytidine(56) methyl-coenzyme ferredoxin: nitrogenase MCON_RS03455 dehydrogenase: (R)-2,3-dihydroxy- histidine-[translation 3-phosphate ammonium hydrogencarbonate hexadecanoyl-[PKS-acp] histidinol MCON_RS01255 synthase: transaminase: synthase: aldo/keto MCON_RS12780 MCON_RS05445 3-methylpentanoate elongation factor 2] cyclophosphate pseudouridine(38- -2'-O)- M reductase dehydrogenase: molybdenum- (S)-2,3,4,5- aroC (R)-NADHX exodeoxyribonuclease ribulose- reductase: RNA 2',3'-cyclic phosphoribulosylformimino- carB carA MCON_RS06900 tributyrin esterase: 40) synthase methyltransferase: I operon ferredoxin: hisD iron protein: tetrahydrodipicolinate (2S)-2-isopropyl- dihydroxy-acid diphthine synthase: bifunctional VII: MCON_RS07770 thiamine phosphate bisphosphate MCON_RS00210 phosphodiesterase: AICAR-phosphate MCON_RS05045 TruA: truA MCON_RS14555 protein C: mcrC MCON_RS12830 nifD nifK carbamoyl- N-acetyl-L- 3-oxosuccinate dehydratase: ilvD MCON_RS06175 chorismate ADP-dependent xseA carbamate kinase: synthase: thiE carboxylase: 9-hydroxy-3,5,7,11,13,15- thpR 38- a 2'-O- γ LL-diaminopimelate an [RNA]-3'- a pseudouridine N-( -L-glutamyl) his phosphate ornithine NAD(P)H-hydrate MCON_RS09555 hexaoxohexadecanoyl- methylcytidine 56 cleaved DNA ethene aminotransferase: (3S)-3-methyl-2- β-alanine MCON_RS13090 ribunucleoside- 40 in tRNA -L-alaninol imidazole synthase a diphthine-[translation dehydratase/ [PKS-acp] in tRNA MCON_RS10280 2'-phosphate oxopentanoate elongation factor 2] a ribonucleoside a single-stranded all-trans-retinol a fatty acid glycerol large 13-DPG NAD(P)H-hydrate L,L- branched-chain- oligodeoxyribonucleotide thiamine phosphate 3-phospho- phosphate subunit: carB 4-methyl-2- diphthine-- epimerase: 5'-monophosphate carbamoyl 2-phosphoglycolate diaminopimelate amino-acid D-glycerate synthase: oxopentanoate ammonia ligase: MCON_RS06545 phosphate carbamoyl L-ornithine transaminase: ilvE (S)-NADHX hisF hisH L-arginine biosynthesis II (acetyl cycle) diaminopimelate branched-chain- MCON_RS09530 phosphoglycerate phosphate L-glutamate imidazole epimerase: amino-acid diphthine-- kinase: pgk bifunctional ile biosynthesis III 54 2030 a [glycine-cleavage MCON_RS01845 transaminase: ω-saturated C55 α (2E,6E)-farnesyl a pseudouridine adenine a [protein]-L- an organic glycerol ammonia ligase: ADP-dependent UDP- -D-glucose phenylacetate [DNA] IPP complex H protein] N 6 acetyl-CoA DNA with lesion ornithine N-acetylglutamyl-phosphate in tRNA in 23S rRNA β-isoaspartate thr hydroperoxide tyr ilvE MCON_RS11030 NAD(P)H-hydrate dolichol phosphate diphosphate phosphate carbamoyltransferase: N-acetyl-gamma- meso- 2-oxoglutarate 3-phospho- tRNA 23S rRNA -dihydrolipoyl-L-lysine acetyl-CoA protein-L- peroxiredoxin: excinuclease a diphthamide- synthase argF glutamyl-phosphate diaminopimelate L-isoleucine NADPH- D-glycerate dehydratase/ (pseudouridine(54) (adenine(2030)-N(6) dihydrolipoyl carboxylase biotin isoaspartate O- threonine MCON_RS07585 ABC subunit tyrosine leu [translation NAD(P)H-hydrate phenylacetate--CoA Dna2/Cas4 domain- dehydrogenase: ammonia-lyase: decarboxylase subunit reductase: biosynthesis I dependent S-layer glycoprotein di-trans,poly-cis- -N(1))- )-methyltransferase carboxylase subunit: methyltransferase: peroxiredoxin: UvrA: uvrA diaminopimelate containing protein: HisF: hisF MCON_RS06195 (from threonine) elongation factor 2] cofactor- epimerase: N-glycosyltransferase ligase: MCON_RS03530 MCON_RS02315 MCON_RS01370 MfnA: mfnA bifunctional glutamate decaprenylcistransferase: methyltransferase 6 RlmJ: rlmJ a [glycine-cleavage MCON_RS06365 βMCON_RS11570 MCON_RS11095 [+ 2 isozymes] decarboxylase: lysA 2,3-bisphosphoglycerate- MCON_RS06545 [+ 2 isozymes] MCON_RS02350 an N - a protein L- - DNA without asp L-citrulline independent AglJ: aglJ 6 ornithine synthase: uppS 1 TrmY: trmY 2030 malonyl-CoA 2-oxobutanoate an alcohol p-tyramine thr an N - methyladenine complex H protein] N isoaspartate D-erythro-1- acetyltransferase/ L-tryptophan biosynthesis gltA phosphoglycerate dependent lesion 54 in 23S rRNA -[(R)-lipoyl]-L-lysine α-methyl ester AICAR (imidazol-4- acetylglutamate lys threonine mutase: phosphoglycerate NADH a 2'- methylpseudouridine N-acetylglutamate di-trans,octa-cis argininosuccinate glu α-D-glucosyl-(C55 ω- UDP phenylacetyl-CoA [DNA] in tRNA yl)-glycerol synthase: argJ kinase: argB ammonia-lyase: Nucleoside and Nucleotide Biosynthesis MCON_RS06185 mutase: diphosphate deoxyribonucleoside N-acetyl-L-glutamate ammonia assimilation cycle III saturated dolichyl phosphate) AMP -undecaprenyl 3-phosphate synthase: glu gln N-acetyl-L-glutamate MCON_RS01370 gln MCON_RS06005 3'-monophosphate 5-semialdehyde (2Z)-2-aminobut- 2,3-bisphosphoglycerate- diphosphate imidazoleglycerol- MCON_RS14155 acetylornithine 2-enoate UMP biosynthesis III independent phosphate anthranilate ammonium inosine-5'-phosphate biosynthesis III pyrimidine deoxyribonucleotides glutamine- transaminase: superpathway of adenosine CMP phosphoglycerate dehydratase: L-arginino- bifunctional synthase nucleotides de novo biosynthesis II de novo biosynthesis I a DNA containing 1518 an [RNA]-3'- hydrolyzing MCON_RS06900 glutamine phosphorylation mutase: pyridin-1-ium-3-carboxylate-5- a tRNA adenine / D-glyceraldehyde (3Z)-hex- a phosphate D-ribose 5- MCON_RS02185 succinate ornithine component I: trpE glu a [LarE]-L-cysteine carbamoyl- synthetase: gln AIR UDP CTP MCON_RS11575 NADPH repair (prokaryotes) thiocarboxylate mononucleotide DL-allothreonine an apurinic/ precursor with 1519 ribonucleoside- 3-phosphate an acyl phosphate 3-en-1-ol ethylphosphate asp phosphate NADPH- hydrogencarbonate CMP adenine in 16S rRNA monoester acetyltransferase/ apyrimidinic site ribosomal RNA 3'-phosphate (5-formylfuran-3-yl) CHAT domain- ribose-5- imidazoleglycerol- argininosuccinate phosphate 2-iminobutanoate anthranilate MCON_RS00530 adenosylcobalamin- a 5' extension N-acetylglutamate PRPP dependent IMP CMP kinase: RNA 3'-terminal acylphosphatase: alkaline aspartate alkaline phosphate lyase: argH synthase: asp 2-phospho- small subunit methyl phosphate containing protein: phosphate 2-oxoglutarate glutamate type I dependent MCON_RS11375 NADPH MCON_RS01805 phosphatase: phosphatase: synthase: argJ CDP ATP-dependent methyltransferase phosphate cyclase: synthase: MCON_RS00610 dehydrogenase: isomerase dehydratase: carB carA L-valine biosynthesis glutamate- glutamine- ribonucleoside- CDP D-glycerate serine synthase: sacrificial sulfur endonuclease III: ribonuclease P: MCON_RS13060 [+ 12 isozymes] MCON_RS09945 MCON_RS05025 MCON_RS09945 MCON_RS01250 anthranilate hydrolyzing 6 A: rsmA 1518 MCON_RS09635 [+ 2 isozymes] RpiA: rpiA arg carbamoyl- gltA -ammonia diphosphate adenosylcobalamin- hydroxymethyltransferase: N -dimethyladenine an [RNA]-3'- 3-(imidazol-4- N-acetyl-L-ornithine adenylosuccinate N5-CAIR nucleoside- transferase LarE: larE MCON_RS08860 MCON_RS13315 (3Z)-hex-3- D-ribulose phosphoribosyltransferase: trpD carbamoyl- phosphopyruvate MCON_RS00940 6 1519 (5-formylfuran-3-yl) a carboxylate ethanol oxaloacetate an alcohol phosphate pyruvate ligase: glnA reductase: dependent /N -dimethyladenine ribonucleoside-2',3'- 5-phosphate yl)-2-oxopropyl 2-oxobutanoate anthranilate phosphate synthase: diphosphate hydratase: eno methyl phosphate en-1-yl acetate synthase large acetolactate MCON_RS07100 ribonucleoside- in 16S rRNA cyclophosphate phosphate phosphoribosyltransferase: trpD Asp-tRNA(Asn) synthase: MCON_RS02405 kinase: ndk pyridin-1-ium-3,5- subunit: carB synthase: dUDP diphosphate a [LarE]-dehydroalanine a 3'-terminal a 5'-phospho- an uncharged histidinol- acetolactate ammonium /Glu-tRNA(Gln) gln (R)-NADPHX bisthiocarboxylate mononucleotide L-ornithine carB carA CTP bifunctional acetaldehyde unsaturated sugar [DNA] a tRNA fragment L-homoserine MCON_RS01755 synthase: nucleoside- reductase: 5-aminoimidazole phosphoenol gly tRNA phosphate carbamoyl phosphate amidotransferase: asp L-cysteine ilvN N-(5-phosphoribosyl)-anthranilate carbamoyl- adenylo-succinate CAIR MCON_RS07100 ribonucleotide biosynthesis I ADP-dependent transaminase: biosynthesis MCON_RS01755 gatC gatA gatB diphosphate pyruvate biosynthesis II (S)-2-acetolactate phosphate NAD(P)H-hydrate MCON_RS06905 ilvN [+ 13 isozymes] adenylosuccinate kinase: ndk dCDP (tRNA-dependent) synthase dehydratase/ phosphoribosylanthranilate PRPP (7,8-dihydropterin- a [2-oxoglutarate asp ketol-acid (S)-2-aceto-2- lyase: phosphoribosylaminoimidazolesuccinocarboxamide dUTP phosphoenolpyruvate pyridin-1-ium-3,5- a [DNA]-3'- an insertion sequence 2-hydroxy-2- a [protein]-L- GDP-α-D- L-histidinol isomerase: MCON_RS05565 large nucleoside- NAD(P)H-hydrate a [LarE]-L-cysteine [DNA] ethanol a ribonucleoside APS O-phospho- hydroxybutanoate MCON_RS11340 synthase: MCON_RS06135 synthase: ppsA 6-yl)methyl β-alanine dehydrogenase E2 protein] ω mannose phosphate aspartate kinase: reductoisomerase: subunit: carB diphosphate amidophosphoribosyltransferase: purF epimerase: dicarboxylate mononucleotide 4-aminobenzoate hydroxyl (R)-pantoate element IS30 methylpropanenitrile proline ( = 180) 5'-monophosphate L-serine 1-(2-carboxyphenylamino)-1- deoxyuridine diphosphate N 6 -dihydrolipoyl-L-lysine DNA polymerase/ peptidylprolyl GDP-mannose O-phosphoserine- ilvC ketol-acid β transposase: adenylyl- MCON_RS07085 ornithine glu 5'-triphosphate kinase: ndk 5-phospho- - MCON_RS06545 dihydrolipoyl 5'/3'- histidinol (2R)-2,3- deoxy-D-ribulose 5-phosphate 3'-5' exonuclease nitrilase: isomerase: 4,6-dehydratase: catalase: -tRNA ligase: L-aspartyl- carbamoyltransferase: reductoisomerase: L-phenylalanine AMP D-ribosylamine (S)-NADPHX MCON_RS00465 nucleotidase sulfate kinase: phosphate carbamoyl SAICAR nucleotidohydrolase: dCTP pyruvate ATP-dependent dehydrogenase: PolX: polX MCON_RS06960 MCON_RS00145 MCON_RS05255 MCON_RS00675 MCON_RS13255 dihydroxy-3- ilvC indole-3-glycerol- asp exodeoxyribonuclease phosphopantothenate/ [+ 51 isozymes] MCON_RS12355 an O-phospho-L- 4-phosphate argF biosynthesis I MCON_RS01110 sacrificial sulfur dihydropteroate MCON_RS02315 SurE: surE phosphatase methylbutanoate phosphate synthase: phosphate phosphoribosylamine- III: xth [+ 2 isozymes] an insertion [+ 4 isozymes] [+ 2 isozymes] Cys (R)-2,3-dihydroxy- adenylosuccinate bifunctional synthase: folP pantothenate synthetase: a [2-oxoglutarate 2-hydroxy-2- domain-containing seryl-[tRNA ] -glycine ligase: purD transferase LarE: larE a 2'-deoxyribonucleoside a [protein]-L- GDP-4-dehydro- acetaldehyde a ribonucleoside PAPS aspartate- dihydroxy-acid MCON_RS05580 chorismate adenylate kinase: dUMP ADP-dependent MCON_RS14610 dehydrogenase E2 sequence IS30 with methylpropanoate 3-methylpentanoate lyase: MCON_RS11340 proline (ω = 0) α-D-rhamnose protein: O-phospho- semialdehyde dehydratase: aspartate MCON_RS08425 6 5'-monophosphate integrated transposon dihydroxy-acid (1S,2R)-1-C-(indol-3- chorismate mutase: thymidylate NAD(P)H-hydrate a 2'- protein] N -lipoyl-L-lysine MCON_RS03925 GAR a [DNA]-3'- L-seryl- dehydrogenase: ilvD L-threonine carbamoyltransferase AICAR dehydratase/ pyridin-1-ium-3-carboxylate-5- 7,8- dehydratase: yl)glycerol 3-phosphate MCON_RS11245 synthase: a [LarE]-dehydroalanine hydroxyl deoxyribonucleoside tRNA:Cys- asd biosynthesis regulatory subunit: ADP thiocarboxylate mononucleotide (R)-pantothenate 3-methyl-2- ilvD MCON_RS07020 phosphoribosylglycinamide NAD(P)H-hydrate dihydropteroate 5'-monophosphate histidinol L-citrulline prephenate guanosine tRNA oxobutanoate tryptophan synthase: MCON_RS11190 formate-- formyltransferase: epimerase: L-aspartate 4- (3S)-3-methyl-2- synthase: MCON_RS07760 trpB adenosylcobalamin- adenosylcobalamin- phosphoribosylaminoimidazolecarboxamide dTMP ribonucleotides de histidinol semialdehyde branched-chain- L-homoserine prephenate aspartate MCON_RS08690 MCON_RS06545 ATP argininosuccinate oxopentanoate dependent dependent ligase: MCON_RS13580 novo biosynthesis dehydrogenase: pscS dehydratase: carbamoyltransferase: dTMP kinase: an [amino-group carrier protein]- 10 a [pyruvate dehydrogenase + + amino-acid ser a 2-deoxy-D- + a guanine adenosyl-cob(III) (2R,3S)-3- H synthase H homoserine synthase: branched-chain- indole ribonucleoside- ribonucleoside- FGAR NADPH a nucleobase H hydrogencarbonate γ 6 cobalt-precorrin-2 a [protein] Ser/Thr 3-phenylpropionitrile MeOH (R)-mevalonate hisD an L-cysteinyl- pheA pyrB MCON_RS08195 ribosyl-base C-terminal- -(L-glutamate 5- E2 protein] N - dehydrogenase: transaminase: FAICAR in tRNA yrinate a,c-diamide isopropylmalate archaeal Cys MCON_RS14155 amino-acid diphosphate diphosphate IMP semialdehyde-2-yl)-L-glutamate dihydrolipoyl-L-lysine [tRNA ] ilvE O-phospho- 3-phenyl-2- dTDP N-acetyl-gamma- tRNA (guanine(10)-N(2) cobalt-factor II C(20) serine/threonine cobyric acid 3-isopropylmalate histidinal MCON_RS03435 transaminase: reductase: reductase: IMP phosphoribosylformylglycinamidine dihydrolipoyl nitrilase: catalase: mevalonate L-arginino-succinate L-homoserine tryptophan synthase: oxopropanoate phosphoribosylaminoimidazolecarboxamide glutamyl-phosphate )-dimethyltransferase: -methyltransferase: protein kinase: synthase: dehydrogenase: peptidyl-tRNA ilvE N-carbamoyl- MCON_RS07100 MCON_RS07100 nucleoside- dehydrogenase: synthase subunit PurS: nucleoside 2- carbonate dehydrogenase: MCON_RS06960 MCON_RS00675 kinase: mvk histidinol hydrolase: L-homoserine val threonine MCON_RS07760 trpB phenylalanine L-aspartate formyltransferase: MCON_RS05855 MCON_RS00875 deoxyribosyltransferase: dehydratase: reductase: MCON_RS05865 MCON_RS07240 MCON_RS05630 MCON_RS11035 MCON_RS05445 diphosphate MCON_RS00540 2 MCON_RS02315 argininosuccinate ATP an N - dehydrogenase: MCON_RS13430 synthase: transaminase: IMP cyclohydrolase: [+ 2 isozymes] MCON_RS08365 MCON_RS05210 an [amino-group carrierMCON_RS06195 protein]- a [pyruvate dehydrogenase a [protein] (L-serine/L- 4-methyl-2- (R)-5- ile kinase: ndk XMP dimethylguanine 10 cobalt-precorrin-3 3-phenylpropanoate adenosylcobyrate formaldehyde hisD lyase: argH thrC MCON_RS11790 dihydroorotase: dADP MCON_RS06285 C-terminal-γ-(5-phospho- 6 threonine) phosphate oxopentanoate phosphomevalonate trp E2 protein] N -lipoyl-L-lysine cys MCON_RS05145 dTTP FGAM in tRNA GMP synthase L-glutamyl)-L-glutamate thr phe a 2-deoxy-D- his arg anaerobic IMP subunit A: a nucleobase CO H O (S)-dihydroorotate phosphoribosylformylglycinamidine ribosyl-base 2 2 nucleoside- ribonucleoside- MCON_RS04480 diphosphate triphosphate cyclo-ligase: MCON_RS07090 glutamine- dihydroorotate kinase: ndk reductase: nrdD guanosine deoxyribonucleotides de novo biosynthesis II hydrolyzing GMP AIR a pseudouridine 1915 a 3-sn-phosphatidyl- α-D-glucopyranose a uridine 13 an epoxyqueuosine 34 4-hydroxy-3- nicotinate adenine dehydrogenase acetoacetyl-CoA acetyl-CoA H O 3-methyl-2-oxobutanoate citrate a nitrile NADH 2 1-phosphate electron synthase subunit in 23S rRNA L-serine in tRNA in tRNA octaprenylbenzoate dinucleotide 23S rRNA GuaA: guaA phosphatidylserine tRNA epoxyqueuosine UbiD family aconitate NAD(+)/ transfer subunit: pyrimidine deoxyribonucleotide phosphoglucomutase: NAD+ synthase: nitrilase: dATP (pseudouridine(1915)- decarboxylase: pseudouridine(13) reductase: decarboxylase: hydratase: NADH kinase: MCON_RS09930 GDP phosphorylation hydroxymethylglutaryl- 3-methyl-2-oxobutanoate MCON_RS03135 MCON_RS08020 MCON_RS06960 adenine salvage N(3))-methyltransferase GMP CoA synthase: dehydrogenase subunit MCON_RS01980 synthase TruD: truD MCON_RS12535 MCON_RS05325 MCON_RS01420 MCON_RS08895 dihydroorotate dTMP dCMP RlmH: MCON_RS01730 UTP and CTP de an N 3 - an L-1- D-glucopyranose a pseudouridine 13 a queuosine 34 dehydrogenase: adenosylcobalamin- adenosylcobalamin- dTMP kinase: MCON_RS04680 VorB: MCON_RS03355 2-octaprenylphenol NAD + D-threo-isocitrate a carboxylate NADPH novo biosynthesis methylpseudouridine 1915 phosphatidylethanolamine 6-phosphate in tRNA in tRNA MCON_RS09925 dependent dependent MCON_RS08195 adenine in 23S rRNA PRPP ribonucleoside- ribonucleoside- UMP dTDP dCDP orotate UMP HMG-CoA CO isobutanoyl-CoA NADH diphosphate diphosphate 2 nucleoside- nucleoside- reductase: reductase: kinase: pyrH orotate UDP diphosphate diphosphate adenine MCON_RS07100 MCON_RS07100 GDP phosphoribosyltransferase: kinase: ndk kinase: ndk deaminase: nucleoside- an N 10 - a 5,10- an [amino-group carrier protein]-C- dCDP α-D-mannose UDP-N-acetyl- nicotinate adenine CTP GTP D-glucopyranose pyrE ade nucleoside- dTTP dCTP AICAR a DNA segment 2-phosphoglycolate α-D-glucosamine (S)-2-acetolactate dGDP diphosphate formyltetrahydrofolate methylenetetrahydrofolate terminal-γ-(L-ornithyl)-L-glutamate adenosylcobalamin- 1-phosphate dinucleotide anaerobic diphosphate bifunctional UDP-N- glucose 1- AMP kinase: ndk acetylornithine dependent ribonucleoside- phosphoglycolate acetolactate ribonucleoside- orotidine 5'- kinase: ndk methylenetetrahydrofolate phosphoglucomutase: recombinase RecJ: acetylglucosamine NAD+ synthase: dehydrogenase: transaminase: diphosphate reductase: phosphatase: decarboxylase: triphosphate anaerobic UTP MCON_RS03135 MCON_RS01855 2-epimerase (non- MCON_RS08020 phosphate hypoxanthine phosphoribosylaminoimidazolecarboxamide dehydrogenase/ MCON_RS06900 MCON_RS13275 MCON_RS12750 budA ribonucleoside- nucleoside- MCON_RS07100 reductase: nrdD GTP CTP synthase: formyltransferase: MCON_RS05855 methenyltetrahydrofolate an [amino-group carrier protein]- hydrolyzing): wecB D-mannopyranose a DNA segment in UDP-N-acetyl-α- D-glucono- orotidine 5'- triphosphate diphosphate CDP glycolate NAD + (R)-acetoin dCTP MCON_RS06590 cyclohydrolase: C-terminal-γ-(L-glutamate 5- 6-phosphate 1,5-lactone phosphate reductase: nrdD kinase: ndk reverse orientation D-mannosamine CTP MCON_RS00945 semialdehyde-2-yl)-L-glutamate decarboxylase: a 5,10- FAICAR a tetrahydrofolate MCON_RS01840 methenyltetrahydrofolate orotidine-5'- dGTP IMP phosphate a 5,10- a single UDP 2'-deoxycytidine D-ribulose cytidine 5,6-dihydrothymine (indol-3-yl) UTP decarboxylase: D-glucopyranose methylglyoxal L-homocysteine 5-phosphate pyrF methenyltetrahydrofolate stranded DNA adenosylcobalamin- nucleoside deaminase: nucleoside deaminase: acetonitrile anaerobic bifunctional hydantoinase: glucose 1- 5-methyltetrahydropteroyltriglutamate- dependent ribonucleoside- MCON_RS01340 phosphoribulokinase: MCON_RS01340 ribonucleoside- UMP methylenetetrahydrofolate deoxyribonuclease MCON_RS09870 nitrilase: dehydrogenase: glyoxalase: - homocysteine methyltransferase: diphosphate reductase: nucleoside deaminase: MCON_RS08175 nucleoside deaminase: triphosphate dehydrogenase/ IV: MCON_RS08065 MCON_RS06960 MCON_RS12750 MCON_RS04815 MCON_RS00705 MCON_RS07100 MCON_RS16545 MCON_RS16545 3-(carbamoylamino)- reductase: nrdD methenyltetrahydrofolate D-ribulose-1,5- D-glucono- a 5'-phosphooligonucleotide dUDP 2'-deoxyuridine uridine 2-methylpropanoate (indol-3-yl)acetate (R)-lactate dUTP met cyclohydrolase: bisphosphate 1,5-lactone MCON_RS00945 an N 10 - formyltetrahydrofolate

an amino a tricarboxylate acid a bile acid

RS10900 RS13695 RS09015

a tricarboxylate an amino a bile acid acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.