LIST OF PUBLICATIONS

Publications in Peer-Reviewed Journals

1. Clinical characterization of dysautonomia in long COVID-19 patients Barizien, N., Le Guen, M., Russel, S., Touche, P., Huang, F. & Vallée, A. Scientific Reports 2021 July

2. Effect of dexmedetomidine on Nociception Level Index-guided remifentanil antinociception Coeckelenbergh, S.; Doria, S.; Patricio, D.; Perrin, L.; Engelman, E.; Rodriguez, A.; Di Marco, L.; Van Obbergh, L.; Estebe, J.; Barvais, L.; Kapessidou, P. European Journal of Anaesthesiology 2021 May

3. Assessing the antinociceptive effect of nitrous oxide to tetanic stimulation in anaesthetised patients with new intra-operative nociception monitors Coulombe, M., Décary, E., Maximos, S., Brulotte, V., Drolet, P., Tanoubi, I., Issa, R., Zaphiratos, V. Verdonck, O., Fortier, L., Godin, N., Idrissi, M., Raft, J., Richebé, P. European Journal of Anaesthesiology 2021 May

4. Nociception level index: do intra-operative values allow the prediction of acute postoperative pain? Ledowski, T., Schlueter, P. & Hall, N. Journal of Clinical Monitoring and Computing 2021 January

5. Impact of chronic treatment by β1-adrenergic antagonists on Nociceptive-Level (NOL) index variation after a standardized noxious stimulus under general anesthesia: a cohort study Bergeron, C., Brulotte, V., Pelen, F., Clairoux, A., Bélanger, M., Issa, R., Urbanowicz, R., Tanoubi, I., Drolet, P., Fortier, L., Verdonck, O., Fortier, A., Espitalier, F., Richebé, P. Journal of Clinical Monitoring and Computing 2021 January

6. Nociception level-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial Funcke, S., Pinnschmidt, H.O., Brinkmann, C., Wesseler, S. British Journal of Anaesthesia 2020 November Letter to the Editor

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

7. Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A. British Journal of Anaesthesia 2020 September

8. Exploration of the Nociception Level (NOL™) Index for Pain Assessment during Endotracheal Suctioning in Mechanically Ventilated Patients in the Intensive Care Unit: An Observational and Feasibility Study T. Shiva Shahiri, Melissa Richard-Lalonde, Philippe Richebé, Céline Gélinas Pain Management Nursing 2020 April

9. Impact of intravenous phenylephrine bolus administration on the nociceptive level index (NOL) Julien Raft, Marie-Andrée Coulombe, Etienne Renaud-Roy, Issam Tanoubi, Olivier Verdonck, Louis- Philippe Fortier, Fabien Espitalier, Philippe Richebe Journal of Clinical Monitoring and Computing 2019 October, 1-8

10. Does nociception monitor‑guided anesthesia affect opioid consumption? A systematic review of randomized controlled trials Fleur S. Meijer, Marieke Niesters, Monique van Velzen, Chris H. Martini, Erik Olofsen, Ruth Edry, Daniel I. Sessler, Eveline L. A. van Dorp, Albert Dahan, Martijn Boon Journal of Clinical Monitoring and Computing 2019 July

11. Guiding Opioid Administration by 3 Different Analgesia Nociception Monitoring Indices During General Anesthesia Alters Intraoperative Sufentanil Consumption and Stress Hormone Release Sandra Funcke, Hans Pinnschmidt, Stefan Wesseler, Charlotte Brinkmann, Burkhard Beyer, Virginija Jazbutyte, Christoph Behem, Constantin Trepte, Rainer Nitzschke Anesthesia & Analgesia 2019 Sept.

12. Correlation between incremental remifentanil doses and the Nociception Level (NOL) index response after intraoperative noxious stimuli Etienne Renaud-Roy, Pierre-André Stöckle, Sarah Maximos, Véronique Brulotte, Lucas Sideris, MD, Pierre Dubé, Pierre Drolet, MD, Issam Tanoubi, Rami Issa, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé Can J Anesth. 2019 April

13. Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial Fleur S. Meijer, Chris H. Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan Anesthesiology 2019 Feb.

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

14. The nociception level index (NOL) response to intubation and incision in patients undergoing video-assisted thoracoscopic surgery (VATS) with and without thoracic epidural analgesia. A pilot study Laurent Bollag, Srdjan Jelacic, Carlos Delgado Upegui, Cynthia Wu, Philippe Richebé F1000Research 2018, 7:875

15. Validation of the PMD100 and its NOL Index to detect nociception at different infusion regimen of remifentanil in patients under general anaesthesia Pierre-André Stöckle, Marco Julien, Rami Issa, Elizabeth Décary, Véronique Brulotte, Pierre Drolet, Margaret Henri, Madeleine Poirier, Jean-François Latulippe, Marc Dorais, Olivier Verdonck, Louis- Philippe Fortier, Philippe Richebé Minerva Anestesiol. 2018 Oct; 84(10):1160-1168

16. Monitoring the Nociception Level Intraoperatively - An Initial Experiences Pether Jildenstål, Katarina Hallén, Katarina Almskog, Johan Sand and Margareta Warren Stomberg J Anest & Inten Care Med. 2018 June; 7(2):1-5

17. Preliminary intraoperative validation of the nociception level index: a noninvasive nociception monitor. Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I. Sessler Anesthesiology 2016 July; 125:193-203

18. Ability of the Nociception Level (NOL), a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia Chris H. Martini, Martijn Boon, Suzanne J. L. Broens, Evelien F. Hekkelman, Lisanne A. Oudhoff, Anna Willemijn Buddeke, Albert Dahan Anesthesiology 2015 Sept.; 123:524-534

19. Monitoring the Nociception Level – A multi-parameter approach Nir Ben-Israel, Mark Kliger, Galit Zuckerman, Yeshayahu Katz, Ruth Edry. Journal of Clinical Monitoring and Computing 2013 Dec.; 27(6):659-668

20. Differentiating between heat pain intensities: the combined effect of multiple autonomic parameters Treister Roi, Kliger Mark, Zuckerman Galit, Itay Goor Aryeh, Eisenberg Elon PAIN®. 2012 Sept.; 153(9):1807-14

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

Clinical Practice and Guidelines

1. Protocolos de analgosedación en pacientes con infección por SARS-CoV-2 (COVID-19) en caso de desabastecimiento [Analgosedation Guidelines for the Treatment of Patients with SARS-CoV-2 (COVID-19)] Manuela García Sánchez, Carola Giménez-Esparza Vich, Sara Alcántara Carmona Spanish Society of Intensive, Critical Medicine and Coronary Units (SEMICYUC)

2. Manejo del paciente con sedación difícil en el ámbito de la Medicina Intensiva (Management of the difficulty to sedate a patient in the Intensive Care Setting) S. Alcántara Carmona, M. García Sánchez Medicina Intensiva 2019 Dec.; https://doi.org/10.1016/j.medin.2019.12.018

3. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU John W Devlin, Yoanna Skrobik, Céline Gélinas, John Needham et al. Crit Care Med. 2018 Sep;46(9):e825-e873

Posters, Abstracts and Presentations

1. A comparison of intraoperative pain measurement with the PMD 200 in fentanyl-based and low opioid anaesthesia: a prospective monocenter pilot study Schwab, P., Steiner, L., Bandschapp, O. SGAR, Switzerland, October 2020, Swiss Medical Weekly 2020;150 (Suppl. 246)

2. Reduced Postoperative Pain In Patients Receiving Opioid-dosing Based On An Artificial Intelligence-driven Nociception Monitor During Elective Noncardiac Surgery Albert Dahan, M.D.,Ph.D., Fleur Meijer, M.D., Tessa Roor, M.D., Samantha Toet, M.D., Paul Calis, M.D., Martijn Boon, M.D.,Ph.D., Christian Martini, M.D.,Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D.,Ph.D. ASA, Virtual (USA), October 2020

3. Impact de l'analgésie peropératoire guidée par le niveau de nociception sur la consommation d'opioïdes intra et postopératoire en chirurgie gynécologique par laparoscopie sous anesthésie Générale M. Idrissi, F. Espitalier, M-È Bélanger, V. Brulotte, V. Zaphiratos, C. Loubert, A. Fortier, L-P. Fortier, N. Godin, O. Verdonck, P. Richebé

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

4. Cost benefit of personalizing intraoperative pain management Saunders R., Weissbrod R. ISPOR Virtual Conference, May 2020

5. Performance assessment of the NOL Index during general anesthesia Shingo Ito, Hiroyuki Seki, Yoshihiko Deguchi, Junko Nakayama, Junko Sannohe, Toshiya Koitabashi ASA, Orlando, FL, USA, October 2019

6. Quel monitorage de la balance nociception-antinociception peut-on utilizer en OFA (Opioid Free Anesthesia)? Lewandowski M., Charier D., Meffre S., Zantour D., Toscano R., Bertheaux C., Molliex S. SFAR, Paris, September 2019

7. Balance nociception-antinociception sous anesthésie générale: quel paramètre d'évaluation? Meffre S., Charier D., Lewandowski M., Zantour D., Toscano R., Bertheaux C., Molliex S. SFAR, Paris, September 2019

8. NOL index shows high sensitivity to detect nociception induced by intubation under different remifentanil dosages Richebé P., McDevitt J., Boselli E., Sbeghen V., Topouzian G.S., Zaphirato V., Fortier L.P., Verdonck O. CAS, Calgary, June 2019

9. Can NOL index calibration help to individualize remifentanil TCI before skin incision? Max Bisdorff, Laurent Perrin, Ionut Tabolcea, Edgard Engelman, Luc Barvais ESA, Vienna, June 2019

10. ED50 and ED95 of remifentanil for tracheal intubation as determined by a monitor of nociception (NOL index) McDevitt J., Boselli E., Sbeghen V., Topouzian G. S., Verdonck O., Richebé P. ESA, Vienna, June 2019

11. Anesthesia’s ultimate challenge: monitor intraoperative analgesia Marta Vidal Seoane, Marta Pérez-De-Lis-Novo, C. Bonome González ESA, Vienna, June 2019

12. Exploration of the Nociception Level (NOL)TM Index for Pain Assessment during Endotracheal Suctioning in Mechanically Ventilated Patients in the Intensive Care Unit Shiva Shahiri, Melissa Richard-Lalonde, Philippe Richebé, Céline Gélinas CPS, Toronto, Canada, April 2019

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

13. Nociception Level (NOL)-guided Analgesia: Influence on Opioid Consumption and Hypotensive Events During Propofol/Remifentanil Anesthesia Albert Dahan. Fleur S. Meijer, Suzanne Broens, Monique van Velzen, Christian Martini Awarded as one of “10 Best of Abstracts: Clinical Science” ASA, San Francisco, USA, October 2018

14. Combined Intraoperative Anesthesia & Analgesia Monitoring Impact on Safety & Recovery: CINAAMON Interim Analysis Etienne Renaud-Roy, Philippe Richebé, Olivier Verdonck, Manon Choinière, Véronique Brulotte, Louis- Philippe Fortier ASA, San Francisco, USA, October 2018 CAS Annual Meeting, Montreal, Quebec, Canada, June 2018

15. Impact of Intravenous Phenylephrine Bolus on Intraoperative Nol Index Values Philippe G.M. Richebé, Véronique Brulotte, Marie-Andree Coulombe, Etienne Renaud-Roy, Omar Elsemin, Manon Choiniere, Pierre Drolet, Louis-Philippe Fortier, Olivier Verdonck ASA, San Francisco, USA, October 2018

16. Performance Assessment of the PMD-200 in Subjects Requiring Surgery Under General Anesthesia Virginia Horne, Borzoo Farhang, Alexander Friend, Max Breidstein ASA, San Francisco, USA, October 2018

17. Nol Index Response After Laryngoscopy Performed with Macintosh Blade Versus GlidescopeTM Videolaryngoscope Virginie Sbeghen, Jason McDevitt, Olivier Verdonck, Valerie Zaphiratos, Veronique Brulotte, Christian Loubert, Pierre A. Drolet, Louis-Philippe Fortier, Marie-Claude Guertin, Philippe Richebé ASA, San Francisco, USA, October 2018 CAS Annual Meeting, Montreal, Quebec, Canada, June 2018

18. Douleur Périopératoire et Délirium. Monitorage de La Nociception : Un nouveau paradigme multiparamétrique (NOL) Dr Pierre-André Stöckle NOL technology symposia during SFAR, Paris, , September 2018

19. Intraoperative nociception monitoring and postoperative recovery after knee arthroplasty Patricia Lavand’homme, Emmanuel Thienpont IASP, Boston, USA, September 2018

20. Detection of Pain under General Anesthesia: Performance Assessment of the PMD-200 Virginia Horne, Alex Friend, Max Breidstein, Borzoo Farhang 12th Annual New England Anesthesia Residents Conference (NEARC), Boston, MA, USA, May 2018

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

21. O noua tehnica non-invaziva pentru monitorizarea durerii si optimizarea analgeziei intraoperatorii: indexul NOL Serban Bubenek, Ruth Edry NOL technology symposia during SRATI congress, Sinaia, Romania, May 2018

22. Nociceptive monitoring during surgery: "Monitoring is our future" Albert Dahan Mini symposium, Leiden, The , March, 2018

23. Missing a Piece? NOL™ (Nociception Level) Technology: Intraoperative Pain Monitoring for Optimizing Analgesia Ruth Edry, Daniel I. Sessler ICISA 2017, Tel Aviv, Israel, Nov. 2017

24. Tailoring analgesia to patients' needs. The Nociception Level Index (NOL) Albert Dahan 3rd Symposium on Anesthesia, Organized by Hospital Da Luz, Lisbon, Portugal, Sept. 2017

25. Comment j’individualise l’analgésie péeriopératoire Philippe G. Richebé SFAR Congress, Paris, France, Sept. 2017

26. Impact of different remifentanil doses on the nociception level index response to intra- operative noxious stimuli Etienne Renaud-Roy, Pierre-André Stöckle, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé CAS, Niagara Falls, ON, Canada, June 2017 (pages 6-7, abstract no. 274885) Euroanaesthesia, Geneva, Switzerland, June 2017 (abstract no. 01AP09-6)

27. NOL Index performance in patients with beta-blockers Ruth Edry, Vasile Recea, Yuri Dikust Euroanaesthesia, Geneva, Switzerland, June 2017 (abstract no. 08AP05-12)

28. Physiologic Indicators for the assessment of acute pain: Recent evidence and new trends Céline Gélinas Canadian Pain Society, May 2017 (pages A36-A37)

29. Exploring the use of an innovative technology for pain assessment during mediastinal tube removal in cardiac surgery patients in the intensive care unit: The Nociception Level (NOL) Index Céline Gélinas, Philippe G. Richebé ESICM, Milan, Oct. 2016

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

30. Quantified Analgesic Effect of Intraoperative 50% N2O Inhalation by the NOL and ANI Nociception Indices Philippe G. Richebé, Elizabeth Decary, Rami Issa, Sarah Maximos, Louis-Philippe Fortier, Olivier Verdonck ASA, Chicago, IL, USA, Oct. 2016

31. Nociception Level (NOL) index alteration after standardized nociceptive stimulus decreases with higher doses of remifentanil Marco Julien, Elizabeth Décary, Rami Issa, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé ESA, London, UK, May 2016

32. Ability of the nociception level, a Multiparameter Composite of Autonomic Signals, to detect noxious stimuli during propofol-remifentanil anesthesia Chris Martini, Martijn Boon, Albert Dahan ASA conference, San Diego, USA, Oct. 2015

33. The level of nociception (NOL) in thoracotomy patients with and without epidural analgesia Laurent Bollag, Srdjan Jelacic, Cynthia Wu, Philippe Richebé EFIC Pain Congress, Vienna, Austria, Sept. 2015

34. Validation of nociception monitor – The NOL Index Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I. Sessler Euroanaesthesia, , June 2015 (abstract no. 1AP12-6)

35. Objective assessment of spinal cord stimulation effectiveness on chronic radicular pain Nir Ben-Israel, Yariv Amos, Noam Racheli, Mark Kliger, Galit Zuckerman, Roi Treister, Elon Eisenberg International Association for the Study of Pain Annual Meeting, Argentina, Oct. 2014

36. Objective measurement of pain levels in patients with radicular pain treated by spinal cord stimulation Nir Ben-Israel, Yariv Amos, Mark Kliger, Galit Zuckerman, Erica Suzan, Elon Eisenberg American Academy of Pain Medicine Annual Meeting, AZ, US, Mar. 2014

37. Detection of noxious stimuli during general anesthesia using the NOL index for nociception level Edry Ruth, Kliger Mark, Zuckerman Galit, Racheli Noam, Katz Yeshayahu, Ben-Israel Nir Euroanaesthesia, Barcelona, Spain, June 2013

38. Non-linear Multi-Parameter Approach for Evaluation of Nociception Level During General Anesthesia Ben-Israel Nir, Zuckerman Galit, Kliger Mark, Katz Yeshayahu, Edry Ruth STA, Phoenix, AZ, Jan. 2013; ASA Conference, Washington DC, Oct. 2012

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

39. A combination of multiple autonomic parameters, rather than each parameter alone, yields significant differentiation between heat pain intensities Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg EFIC Conference, Germany, 2011

40. Toward automatic pain monitoring: Method for classification of pain level based on statistical processing of multiple non-invasive physiological measures Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg IPA Conference, Israel, 2010

Review Articles

1. Objective monitoring of nociception: a review of current commercial solutions Thomas Ledowski British Journal of Anaesthesia 2019 Aug.; 123 (2): e312–e321

2. The quantification and monitoring of intraoperative nociception levels in thoracic surgery: a review Ismael Ghanty, Stefan Schraag Journal of Thoracic Disease [Online], 11.9 (2019): 4059-4071 doi: 10.21037/jtd.2019.08.62

3. Pain monitor: reality or fantasy in ambulatory patients Borzoo Farhang, Donald Mathews Current Opinion in Anesthesiology 2019 Dec.; 32(6):727-734 doi: 10.1097/ACO.0000000000000797

4. Assessing nociception: steps towards intraoperative “full monitoring” ‒ Editorial Review Manuel Á. Gómez-Ríos, Alfredo Abad-Gurumeta, José M. Calvo-Vecino Minerva Anestesiologica 2018 Oct.; 84(10):1123-5

5. Le monitorage de la douleur peropératoire : actualités et perspectives (Intraoperative pain monitoring: Update and future directions) Pierre-André Stöckle, Philippe Richebé Anesthésie & Réanimation 2018 May; 4(3):204-214

6. Monitoring nociception—getting ‘there yet’ might be easier with a road map Thomas Ledowski British Journal of Anaesthesia. 2017 Oct; 119 (4): 716–7

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.

7. Next steps in ICU pain research Kathleen Puntillo , Céline Gélinas and Gerald Chanques Intensive Care Med. 2017 Sep; 43(9):1386-1388

8. Digital innovations and emerging technologies for enhanced recovery programmes Frederic Michard, Tong Joo (TJ) Gan, Henrik Kehlet Br J Anaesth 2017; 119(1):31-39

9. Objective Assessment of Acute Pain Helen Laycock, Carsten Bantel J Anesth Clin Res 2016; 7:6

10. Physiological Signal Processing for Individualized Anti-nociception Management During General Anesthesia: a Review Julien De , Vincent Bonhomme, Mathieu Jeanne, Emmanuel Boselli, Matthias Gruenewald, Regis Logier, Philippe Richebé Yearb Med Inform. 2015 Aug; 10(1):95-101

11. Assessing pain objectively: the use of physiological markers Rachel Cowen, Maria Stasiowska, Helen Laycock, Carsten Bantel. Anaesthesia. 2015 July; 70(7):828-47

12. Acute psychosocial stress reduces pain modulation capabilities in healthy men Geva Nirit, Pruessner Jens, Defrin Ruth PAIN® 2014 Nov.; 155(11):2418-25

13. Multi-parameter autonomic-based pain assessment: More is more? Marco L. Loggia, Vitaly Napadow PAIN® 2012; 153:1779–1780

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PMD-200TM and its NOL® Index are commercially available in Europe, Canada, Latin America, UAE, Australia and Israel. Not commercially available in the USA.