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Prep News Coverage PrEP News Coverage Contents HIV Infection Despite PrEP: 6 Things You Need to Know ............................................................................. 2 The BodyPRO ........................................................................................................................................... 2 Maraviroc-Containing Regimens Safe, Tolerable When Taken for HIV Prevention ..................................... 5 NIAID/NIH ................................................................................................................................................ 5 Maraviroc drug safe, well-tolerated when taken as PrEP to prevent HIV infection .................................... 7 News Medical .......................................................................................................................................... 7 First Man to Become HIV-Positive While on PrEP Is Rare Exception ........................................................... 9 Advocate .................................................................................................................................................. 9 AHF: PrEP Patient’s Drug-resistant HIV Infection; Bone Loss, Fractures in Others, Suggest Caution ........ 10 Business Wire ......................................................................................................................................... 10 Panic Over HIV Infection While on PrEP Is Not Necessary ......................................................................... 11 TheBody ................................................................................................................................................. 11 PrEP Is Not Magic—and Treating It That Way Undermines Its Incredible Power ...................................... 12 Slate ....................................................................................................................................................... 12 Almost-certain case of PrEP failure due to drug resistance reported at CROI 2016 .................................. 14 Aidsmap ................................................................................................................................................. 14 The first case of HIV contraction while taking preventative drugs has been documented ....................... 17 AOL News ............................................................................................................................................... 17 Man on Daily PrEP Regimen Contracts HIV, According to Study ............................................................... 17 Gawker ................................................................................................................................................... 17 Case report details gay man becoming HIV+ while on PrEP ...................................................................... 19 Metro Weekly ........................................................................................................................................ 19 Gay Man Taking PrEP Daily Has Tested Positive For HIV ........................................................................... 20 Queerty .................................................................................................................................................. 20 Gay man taking daily HIV prevention pills contracts resistant strain of the virus - in first recorded case of PrEP failing ................................................................................................................................................. 22 DailyMail ................................................................................................................................................ 22 Researchers Report First Man to Contract HIV While Using Truvada as PrEP Daily .................................. 23 Frontiers Media ..................................................................................................................................... 23 Modest kidney function decline in people taking Truvada for PrEP supports need for monitoring ......... 25 Aidsmap ................................................................................................................................................. 25 PrEP News Coverage TAF/emtricitabine maintains viral suppression as well as TDF regimens with less bone and kidney toxicity ................................................................................................................................................................... 28 Aidsmap ................................................................................................................................................. 28 NIH-funded Study Finds Effect of PrEP on Bone Density Is Reversible ...................................................... 30 NIH Press Release .................................................................................................................................. 30 Switching to Emtricitabine/Tenofovir Alafenamide (F/TAF) Maintains Viral Suppression With Better Bone and Kidney Safety ...................................................................................................................................... 31 TheBodyPro.com .................................................................................................................................... 31 Bone density recovers quickly after stopping PrEP ................................................................................... 32 Aidsmap ................................................................................................................................................. 32 Halting Truvada restores BMD ................................................................................................................... 34 Healio ..................................................................................................................................................... 34 The Kidney Report - CROI 2016 .................................................................................................................. 35 NATAP .................................................................................................................................................... 35 ViiV and Janssen take long-acting HIV regimen into phase III ................................................................... 38 PMLive ................................................................................................................................................... 38 Injected Long-Acting Cabotegravir Protects Macaques From Injected SIV ............................................... 39 NATAP .................................................................................................................................................... 39 CROI 2016: Long-Acting Cabotegravir PrEP Injection Tolerable and Acceptable, but Dose Adjustment Needed ...................................................................................................................................................... 41 HIV&Hepatitis ........................................................................................................................................ 41 Injectable PrEP Given Every 8 Weeks Passes Safety Test .......................................................................... 43 HIVEqual ................................................................................................................................................ 43 CROI 2016: Long-Acting Injectable Cabotegravir + Rilpivirine Works Well as HIV Maintenance Therapy . 44 HIV&Hepatitis ........................................................................................................................................ 44 The Possibility of PrEP that's Not Truvada ................................................................................................. 46 HIVEqual ................................................................................................................................................ 46 HIV Infection Despite PrEP: 6 Things You Need to Know The BodyPRO Damon Jacobs 26 February 2016 PrEP News Coverage A thorough case study has revealed the likely acquisition of HIV by a 43-year-old gay man in Toronto who was adherent to pre-exposure prophylaxis (PrEP). Presented at CROI 2016 on Feb. 25, this is the first documented case of "PrEP failure," and it is spurring a lot of community and scientific discussion. "PrEP works when taken. Very rarely, PrEP with FTC/TDF [emtricitabine/tenofovir, Truvada] may fail to provide full protection against rare multidrug resistant viruses," said noted PrEP and HIV prevention researcher Robert Grant in an interview with BETA. "If that happens, HIV treatment is highly effective and prolongs life to normal levels and makes people less infectious." It's not surprising that HIV community members, educators and care providers have many questions and concerns when they learn about this particular case. Let's break down the information to address some of the top questions we're likely to hear from people who are on PrEP, considering PrEP use or living with HIV. Why didn't PrEP prevent HIV infection in this person? PrEP did not prevent infection in this instance because the person was exposed to a strain of HIV that had become resistant to several antiretroviral medications. These medications included (but were not limited
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