The Future of Genomic Medicine III Friday, March 5 and Saturday, March 6, 2010 • The Neurosciences Institute Auditorium • , Faculty

David A. Flockhart, M.D., Ph.D. Stephen B. Liggett, M.D. Will Parsons, M.D., Ph.D. Course Co-Directors Guest Faculty Harry and Edith Gladstein Chair in Cancer of Medicine and and Assistant Professor Eric J. Topol, M.D. Russ B. Altman, M.D., Ph.D. Director of the Cardiopulmonary Genomics Department of Pediatrics Section of Director, Scripps Translational Professor of Bioengineering, Genetics, Professor of Medicine, Medical Genetics Program Hematology-Oncology Institute and Medicine and University of Maryland School of Medicine Baylor College of Medicine The Gary and Mary West Chair of Chairman, Department of Bioengineering Houston, Texas Indiana University School of Medicine Baltimore, Maryland Director, Biomedical Informatics Training Innovative Medicine Indianapolis, Indiana Thomas T. Perls, M.D., M.Ph. Program Greg Lucier Chief Academic Officer, Scripps Associate Professor of Medicine Stanford University Kathleen M. Giacomini, Ph.D. , California Chairman and CEO Director, New England Centenarian Study Stanford, California Professor, Departments of Bioengineering Life Technologies Corporation School of Medicine and Robert L. Strausberg, Ph.D. and Therapeutic Sciences, Cellular Nir Barzilai, M.D. Carlsbad, California Boston University Medical Center Director for Collaborative Sciences and Molecular Pharmacology and Ludwig Institute for Cancer Research Ltd. The Ingeborg and Ira Leon Rennert Boston, Massachusetts Pharmaceutical Chemistry Elaine R. Mardis, Ph.D. Chair of Aging Research New York, New York Associate Professor in Genetics and Stephen R. Quake, Ph.D. Professor of Medicine and Molecular University of California, San Francisco Molecular Microbiology Co-Chair, Department of Bioengineering Genetics San Francisco, California Investigator, Howard Hughes Medical Organizing Committee Director, Institute for Aging Research Co-Director, The Center at David B. Goldstein, Ph.D. Institute Samuel Levy, Ph.D. Albert Einstein College of Medicine Washington University Director, IGSP Center for Stanford University Director of Genome Sciences Bronx, New York Washington University School of Medicine Variation Stanford, California Scripps Genomic Medicine St. Louis, Missouri Bruce Beutler, M.D. Professor Scripps Translational Science Institute Stephen W. Scherer, Ph.D. Professor and Chairman Molecular Genetics & Microbiology Marco A. Marra, Ph.D. La Jolla, California Senior Scientist, Department of Genetics Department of Genetics Duke University Director, Genome Sciences Centre and Genomic Biology Sarah S. Murray, Ph.D. The Scripps Research Institute Durham, North Carolina Senior Scientist, BC Cancer Research The Hospital for Sick Children Director of Genetics La Jolla, California Hakon Hakonarson, M.D., Ph.D. Centre Professor, Department of Molecular and Scripps Genomic Medicine Nancy J. Cox, Ph.D. Director, Center for Applied Genomics BC Cancer Agency Medical Genetics Scripps Translational Science Institute Director, Influenza Division Associate Professor of Pediatrics Professor, Medical Genetics The Center for Applied Genomics, Hospital La Jolla, California Director, WHO Collaborating Center for Department of Pediatrics and Division of The University of British Columbia for Sick Children Nicholas J. Schork, Ph.D. Surveillance, Epidemiology and Control of Genetics Vancouver, British Columbia, Canada University of Toronto, Ontario, Canada Influenza Director of Research The Children’s Hospital of Philadelphia Paola Sebastiani, Ph.D. National Centers for Disease Control and Joseph Nadeau, Ph.D. Scripps Genomic Medicine University of Pennsylvania School of Professor of Biostatistics Prevention James H. Jewel Professor and Chair of Scripps Translational Science Institute Medicine Boston University School of Public Health Atlanta, Georgia Genetics La Jolla, California Philadelphia, Pennsylvania Boston, Massachusetts George D. Demetri, M.D. Case Western Reserve University Michael R. Hayden, MB, ChB, Ph.D. Doug C. Wallace, Ph.D. Associate Professor, Department of Medicine Cleveland, Ohio Director and Senior Scientist Donald Bren Professor of Molecular Keynote Speaker Harvard Medical School Karen E. Nelson, Ph.D. Centre for Molecular Medicine and Medicine Director, Center for Sarcoma and Bone , M.D., Ph.D. Therapeutics, Director of Human Microbiology Director, Center for Molecular and Oncology President, Institute for The J. Institute Mitochondrial Medicine and Genetics Dana-Farber Cancer Institute University Killam Professor, Department Seattle, Washington Rockville, Maryland (MAMMAG) Boston, Massachusetts of Medical Genetics University of British University of California, Irvine School of Columbia Deborah Nickerson, Ph.D. Andrew Dillin, Ph.D. Medicine Vancouver, British Columbia, Canada Investigator, Howard Hughes Medical Professor of Genome Sciences Irvine, California Institute Stephen F. Kingsmore, Ph.D. Adjunct Professor of Bioengineering Director, Glenn Center for Aging Research President , School of Associate Professor, Salk Institute National Center for Genomic Resources Medicine La Jolla, California Santa Fe, New Mexico Seattle, Washington Scripps Translational Science Institute Dear Colleague, Scripps Translational Science Institute (STSI), a bridge between the We invite you to another exciting day and a half program on Friday, March 5 and Saturday, Scripps Health organization and The Scripps Research Institute, is March 6, 2010 in beautiful San Diego, California. Once again, this year’s program will be held transforming and integrating clinical and basic research by promoting interdisciplinary omics-based translational research efforts which at The Neurosciences Institute Auditorium. advance the field of individualized . STSI is As you will see in the enclosed program, we are inviting a dynamic group of speakers who will cover a supported by the NIH flagship program, Clinical and Translational wide range of topics. Presentations will focus around the whole genomic sequencing of people during Science Award (CTSA). Besides Scripps, there are collaborations with the Friday afternoon session and will be followed by our annual evening welcome reception at Scripps the Burnham Institute for , Children’s Hospital of Philadelphia, Genomics Institute of the Novartis Research Foundation, Translational Science Institute. On Saturday, we are excited to host the distinguished Dr. Leroy Hood J. Craig Venter Institute, Salk Institute for Biological Studies, as our keynote speaker. Dr. Hood is recognized as one of the world’s leading scientists in molecular San Diego State University, San Diego Supercomputer Center and and genomics. Dr. Hood will address the group on The Future of Genomic Medicine. The Neurosciences Institute on the San Diego Mesa. The Institute Our goal is to continue to examine the salient progress and challenges in the field of genomics that will emphasizes three dimensions of translation: i) traditional bench-to- bedside, ii) bedside-to-bench and back-to-bedside, and iii) bedside to change medicine with concise presentations allowing ample time for interactive panel and participant the community medicine. STSI harnesses the excitement of today’s discussions following each topic series. scientific advances to catapult tomorrow’s preventions, betterment of We look forward to your participation and another successful conference, health, and the training of future leaders of academic medicine. For more information on Scripps Health, visit www.scripps.org. For more information on The Scripps Translational Science Institute Eric J. Topol, M.D. and Robert L. Strausberg, Ph.D. (STSI), visit www.stsiweb.org. Course Co-Directors The J. Craig Venter Institute The JCVI is a not-for-profit research institute in Rockville, MD and Educational Objectives La Jolla, CA dedicated to the advancement of the science of • Demonstrate the unmet needs of medicine today with respect to more targeted, genomics; the understanding of its implications for society; and individualized prevention and treatments. communication of those results to the scientific community, the • Discuss the opportunities of the genome, proteome, discovery to change public, and policymakers. Founded by J. Craig Venter, Ph.D., the JCVI medical practice as it exists today. is home to approximately 400 scientists and staff with expertise in • Assess how changes and advances in technology are rapidly ushering in a whole array human and evolutionary biology, genetics, bioinformatics/informatics, of new pathways for individualized medicine of the future. information technology, high-throughput DNA sequencing, genomic • Explore specific strategies in cancer, cardiovascular and pharmacogenomic interventions. and environmental policy research, and public education in science and science policy. The legacy organizations of the JCVI are: The Institute for Genomic Research (TIGR), The Center for the Advancement of Who Should Attend? Genomics (TCAG), the Institute for Biological Energy Alternatives • Human geneticists • Health care professionals of all (IBEA), the Joint Technology Center (JTC), and the J. Craig Venter • Genomic scientists disciplines interested in the future of Science Foundation. The JCVI is a 501 (c) (3) organization. • Researchers medicine, especially with respect to For more information on the J. Craig Venter Institute, visit www.JCVI.org. • Physicians individualized therapies. Program Friday, March 5 and Saturday March 6, 2010

Friday, March 5, 2010 Saturday, March 6, 2010 Noon Registration and Lunch Saturday Morning Session 12:30p.m. Welcome and Overview—Eric J. Topol, M.D. 12:35p.m. Genomic Medicine and Beyond—Greg Lucier 7:15a.m. Registration and Breakfast 7:45a.m. Welcome Session: of People Eric J. Topol, M.D. and Robert L. Strausberg, Ph.D. Moderators: Robert L. Strausberg, Ph.D. and Nicholas J. Schork, Ph.D. 8:00a.m. Keynote: The Future of Genomic Medicine 1:00p.m. Paired Normal and Tumor Sequencing Leroy Hood, M.D., Ph.D. Elaine R. Mardis, Ph.D. 1:20p.m. Rapid Individual Sequencing Session: Cancer Genomics Stephen R. Quake, Ph.D. Moderators: Robert L. Strausberg, Ph.D. 1:40p.m. Multiple Individual Sequencing and Hakon Hakonarson, M.D., Ph.D. Stephen F. Kingsmore, Ph.D. 2:00p.m. Whole Genome by Multiple Platforms 9:00a.m. Overview Saturday Afternoon Session I Samuel Levy, Ph.D. Robert L. Strausberg, Ph.D. Moderators: Nicholas J. Schork, Ph.D. 2:20p.m. Refreshment Break, View Exhibits 9:15a.m. Genomic Landscape of Cancer and Bruce Beutler, M.D. and Networking Will Parsons, M.D., Ph.D. Noon H1N1 Influenza 2:50p.m. Exome Sequencing Nancy J. Cox, Ph.D. Deborah Nickerson, Ph.D. 9:30a.m. Large-scale Cancer Clinical Genomics 12:15p.m. George D. Demetri, M.D. 3:10p.m. Will Missing Heritability be Karen E. Nelson, Ph.D. Filled in by Sequencing? 9:45a.m. Refreshment Break, View Exhibits 12:30p.m. Genomics of the Host Joseph Nadeau, Ph.D. and Networking Bruce Beutler, M.D. 3:30p.m. Extrapolating Genomic Data for 10:15a.m. Individualized Cancer Genomics Prevention of Diseases 12:45p.m. MRSA Sarah S. Murray, Ph.D. Marco A. Marra, Ph.D. Nicholas J. Schork, Ph.D. 3:50p.m. Structural Variants and 10:30a.m. Pediatric Cancers 1:00p.m. AIDS and Hepatitis C David B. Goldstein, Ph.D. Genomic Medicine Hakon Hakonarson, M.D., Ph.D. Stephen W. Scherer, Ph.D. 1:15p.m. Afternoon Panel I Discussion 10:45a.m. Morning Panel Discussion and Q&A 4:10p.m. Afternoon Panel Discussion and Q&A and Q&A 11:15a.m. 3rd Annual Scripps Genomic 1:45p.m. Refreshment Break, View Exhibits 5:00– Friday Evening Welcome Reception Medicine Award Presentation and Networking 7:00p.m. Scripps Translational Science Institute 11:30a.m. Lunch, View Exhibits and Networking 3344 North Torrey Pines Court, Suite 300 La Jolla, California 92037 Conference Location Afternoon Session II: Genomics Of Health And Aging San Diego, California Moderators: Sarah S. Murray, Ph.D. and Stephen W. Scherer, Ph.D. Beautiful San Diego is California’s second largest 2:15p.m. Model Organism city where blue skies keep watch over 70 miles of Andrew Dillin, Ph.D. beaches and an almost perfect climate provides an 2:30p.m. Genomics of Aging idyllic setting for partaking in the many business Nir Barzilai, M.D. and leisure activities. Nestled on the northern edge 2:45p.m. Mitochondria and Aging of San Diego is La Jolla. La Jolla means “The Jewel” Doug C. Wallace, Ph.D. in Spanish and it is the jewel of San Diego. Located 3:00p.m. Centenarians just 15 minutes from downtown, it is known Thomas T. Perls, M.D., M.Ph. throughout the world for its beautiful beaches and Paola Sebastiani, Ph.D. and year-round temperate weather. La Jolla is an 3:15p.m. Healthy Aging exquisite combination of a southern European resort atmosphere and Southern California fun. In addition Eric J. Topol, M.D. Afternoon Session III: to fine restaurants, it is unique in that it maintains 3:30p.m. Afternoon Panel II Discussion Moderators: Samuel Levy, Ph.D. and Q&A and Eric J. Topol, M.D. its quaint village atmosphere within a sophisticated 4:00p.m. Refreshment Break, View Exhibits cosmopolitan environment offering a varied selection 4:30p.m. Pediatric Pharmacogenomics and Networking of hotels, shopping, dining, events and attractions. Michael R. Hayden, MB, ChB, Ph.D. Furthermore, San Diego is the model conference 4:45p.m. Metformin location as a city leading the nation in biomedical, Kathleen M. Giacomini, Ph.D. high-tech and telecommunication industries. 5:00p.m. Cardiovascular Pharmacogenomics Stephen B. Liggett, M.D. www.sandiego.org www.lajolla.com 5:15p.m. Warfarin David A. Flockhart, M.D., Ph.D. 5:30p.m. Pharmacogenomics Network Exhibit and Support Opportunities Russ B. Altman, M.D., Ph.D. For information on exhibit and support 5:45p.m. Afternoon Panel III Discussion opportunities during this and many other Scripps and Q&A educational conferences, please contact Scripps 6:15p.m. Wrap-Up Conference Services & CME at: 6:30p.m. Adjourn www.scripps.org/conferenceservices [email protected] 858-652-5400

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either the ocean and championship golf course, or a . Directions: . St. Rd meticulously tended, lush garden. ct Pines e . Torrey • From Interstate 5, exit at Genesee Avenue and sp t o S 5 r rl go west for about 0.8 mile to the second stoplight P a 52 Make your reservations early! A specially priced Pe La Jolla block of rooms is being held until February 12, (not counting any stoplights at the I-5 exit). Depicts approx. a 2-mile radius. 2010. After that time, reservations will be accepted • Turn right (north) onto John Jay Hopkins Drive. • The Neurosciences Auditorium will be on your left on a space and rate availability basis only. Be sure to (directly opposite General Atomics Court). request the Scripps reduced rate of only $185 per night plus tax. This low rate also includes: Parking and Transportation: • Discounted self parking ($15) • Directional parking signs will be displayed and additional information regarding available parking will be given • Complimentary guestroom internet service upon registration. • Parking on Friday, March 5: Parking will be available at the parking lot across from The Neurosciences Please make your own hotel reservations and request the Auditorium on General Atomics Ct. Scripps rate of $185 (plus tax, based on availability) at: • Overflow Parking:Available at The Hilton La Jolla Torrey Pines (Friday only), $10/day for self parking and $15/day for valet. There will be a looping shuttle available from the Hilton La Jolla Torrey Pines to The The Hilton La Jolla Torrey Pines Hotel Neurosciences Institute. 10950 North Torrey Pines Road • Transportation to Welcome Reception on Friday March 5: There will be a looping shuttle between The La Jolla, California 92037 Neurosciences Institute, The Scripps Translational Science Institute and The La Jolla Hilton Torrey Pines Hotel beginning at 4:30p.m. and ending at 8:00p.m. Reservations: 800-HILTONS (4458667) • Parking on Saturday, March 6: Parking will be available in The Neurosciences Institute parking lot. Online at: www.lajollatorreypines.hilton.com • Parking for Scripps Employees: Scripps employees are encouraged to park in the north employee parking Hotel Direct: 858-558-1500 lot (directly across from Scripps Green Hospital) and walk south to The Neurosciences Institute Auditorium Fax: 858-450-4584 (approx. 500 ft.). Be sure to use booking code SR12 when making your reservation. Registration Fee: $80 Complimentary registration for all students, residents and fellows The Future of Genomic Medicine III (Please enclose proof of status when registering.) Friday, March 5 and Saturday, March 6, 2010 Registration includes the online learning module, course The Neurosciences Institute Auditorium • San Diego, California tuition, breakfast(s), lunch and refreshment breaks. Registration Upon registration you will receive information on how to access the online learning module. The objective of this module is to become familiar with FIRST NAME, MIDDLE INITIAL, LAST NAME DEGREE (M.D., PH.D., etc.) the common terms, tools and current research being done in the area of genomic medicine. SPECIALTY HOSPITAL/AFFILIATION Please note, this course does not offer STREET ADDRESS Continuing Medical Education credits.

CITY STATE/PROVINCE ZIP CODE/POSTAL CODE COUNTRY To Register Online: www.scripps.org/conferenceservices OFFICE TELEPHONE FAX Phone: 858-652-5400

EMAIL ADDRESS Fax: 858-652-5565 Payment Method Mail: Scripps Conference Services & CME ___ CHECK Please make payable to: Scripps ___ Visa ___ Mastercard ___ AMEX ___ Discover Genomic Medicine Conference 11025 North Torrey Pines Road CREDIT CARD NUMBER EXPIRATION DATE SECURITY CODE Suite 200

NAME ON CARD Mailstop: SCRC 200 La Jolla, California 92037 BILLING ADDRESS IF DIFFERENT FROM ABOVE Questions? Contact Scripps Conference Services & CME Phone: 858-652-5400 AUTHORIZED SIGNATURE DATE Email: [email protected]

Office Use Only Date Recieved Recieved Amount Check No./Approval CD Confirmation Sent Initials Refund, Substitution and Cancellation Policy The course tuition is refundable, minus a $40 processing fee, if your cancellation is received in writing no later Recording and Photography Clause than Friday, February 26 2010. Attendee substitutions are allowed, but notification must be made in writing by Scripps reserves exclusive rights to record (audio Friday, February 26, 2010. After this date, under no circumstances will refunds, credits, or substitutions be granted. and video) and/or photograph all conference No refunds or credits will be given to “no shows.” Scripps reserves the right to cancel this conference, in which proceedings for use in marketing materials, case a full refund of your registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) presentations and course content sales. in the case of Scripps cancellation. Conference Services & CME 11025 North Torrey Pines Road, Suite 200 PERMIT NO.1981 La Jolla, CA 92037

The Future of Genomic Medicine III Friday, March 5 and Saturday, March 6, 2010 The Neurosciences Institute Auditorium • San Diego, California