1 An endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys sp.) from 2 Indonesia 3 4 Niccolo Alfano1, Johan Michaux2,3, Pierre-Henri Fabre4,5, Serge Morand2,3, Ken Alpin5, Kyriakos 5 Tsangaras1*, Ulrike Löber1, Yuli Fitriana6, Gono Semiadi6, Yasuko Ishida7, Kristofer M. Helgen5, 6 Alfred L. Roca7, Maribeth V. Eiden8, Alex D. Greenwood1,9# 7 1 Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany 8 2 Conservation Genetics Unit, Institute of Botany, University of Liège, Liège, Belgium 9 3 CIRAD, Campus international de Baillarguet, Montpellier Cedex, France 10 4 Harvard Museum of Comparative Zoology, Cambridge, Massachusetts, USA 11 5 National Museum of Natural History, Smithsonian Institution, Washington, DC, USA 12 6 Museum Zoologicum Bogoriense, Research Center For Biology, Indonesian Institute of Sciences 13 (LIPI), Cibinong, Indonesia 14 7 Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA 15 8 Section on Directed Gene Transfer, Laboratory of Cellular and Molecular Regulation, National 16 Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA 17 9 Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany 18 19 Running Title: 20 #Address correspondence to Alex D. Greenwood,
[email protected] 21 *Present address: Kyriakos Tsangaras, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. 22 Word counts: 23 Abstract: 24 Main text: 25 Number of figures: 26 Number of tables: 27 28 29 30 31 32 ABSTRACT 33 Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated from 34 a cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or more 35 intermediate as yet unknown hosts.