ALOXE3 Antibody Cat. No.: 23-475

ALOXE3 Antibody

Immunofluorescence analysis of U2OS cells using ALOXE3 antibody (23-475) at dilution of 1:100. Blue: DAPI for nuclear staining.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of IMMUNOGEN: human ALOXE3 (NP_067641.2).

TESTED APPLICATIONS: IF, WB

WB: ,1:500 - 1:2000 APPLICATIONS: IF: ,1:50 - 1:200

POSITIVE CONTROL: 1) 22Rv1

2) MCF7

October 2, 2021 1 https://www.prosci-inc.com/aloxe3-antibody-23-475.html 3) Mouse skeletal muscle

4) Mouse testis

5) Rat intestine

PREDICTED MOLECULAR Observed: 81kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: ALOXE3

Hydroperoxide isomerase ALOXE3, -type 3, Epidermal LOX-3, e- ALTERNATE NAMES: LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3

GENE ID: 59344

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This is a member of the lipoxygenase family, which are catabolized by -derived compounds. The encoded is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z- trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha BACKGROUND: (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in , implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase on 17p13.1. in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.

ANTIBODIES FOR RESEARCH USE ONLY.

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