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Hydrogels and Dentin–Pulp Complex Regeneration: from the Benchtop to Clinical Translation
polymers Review Hydrogels and Dentin–Pulp Complex Regeneration: From the Benchtop to Clinical Translation Marwa M. S. Abbass 1,2 , Aiah A. El-Rashidy 2,3 , Khadiga M. Sadek 2,3 , Sara El Moshy 1,2, Israa Ahmed Radwan 1,2 , Dina Rady 1,2 , Christof E. Dörfer 4 and Karim M. Fawzy El-Sayed 2,4,5,* 1 Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11562, Egypt; [email protected] (M.M.S.A.); [email protected] (S.E.M.); [email protected] (I.A.R.); [email protected] (D.R.) 2 Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11562, Egypt; [email protected] (A.A.E.-R.); [email protected] (K.M.S.) 3 Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo 11562, Egypt 4 Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 24105 Kiel, Germany; [email protected] 5 Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo 11562, Egypt * Correspondence: [email protected] Received: 22 October 2020; Accepted: 10 November 2020; Published: 9 December 2020 Abstract: Dentin–pulp complex is a term which refers to the dental pulp (DP) surrounded by dentin along its peripheries. Dentin and dental pulp are highly specialized tissues, which can be affected by various insults, primarily by dental caries. Regeneration of the dentin–pulp complex is of paramount importance to regain tooth vitality. The regenerative endodontic procedure (REP) is a relatively current approach, which aims to regenerate the dentin–pulp complex through stimulating the differentiation of resident or transplanted stem/progenitor cells. -
Thesis of a Hollow Fibre Boronic Acid Fixed Carrier Membrane System for Saccharide Separation
University of Bath PHD Chemical modification of polysulfone Cox, Owen Award date: 2013 Awarding institution: University of Bath Link to publication Alternative formats If you require this document in an alternative format, please contact: [email protected] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 07. Oct. 2021 Acknowledgements First and foremost I would like to thank my supervisors, Dr Semali Perera and Professor Tony James for their guidance and funding throughout my project. A big thanks to all the past and present members of the James group for generally being a friendly helpful bunch of lads. Special thanks goes to those who helped me out in my first year; Kit, Francois, Axe, Kelly, Maggy, Wenbo, Sabrina etc. for making me feel at home and welcome. An extra special thanks to Flower for constantly listening to my never ending stream of questions and not once seeming annoyed by it. -
Review Article 51
Review article Egypt. J. Chem. Vol. 60, No.5, pp. 723 - 751 (2017) 51 1H-Indole-3-carboxaldehyde: Synthesis and Reactions Eslam R. El-Sawy*, Heba M. Abo-Salem and Adel H. Mandour Chemistry of Natural Compounds Department, National Research Centre, P.O. Box 12622 Dokki, Giza, Egypt . 1H-Indole-3-carboxaldehyde and its derivatives have represented the key intermediates for the preparation of biologically active compounds as well indole alkaloids. Also, they are important precursors for the synthesis of divers heterocyclic derivatives because their carbonyl groups facilely undergo C–C and C–N coupling reactions and reductions. This review highlights the recent advances in 1H-indole-3-carboxaldhyde chemistry via discussing different synthetic procedures developed for the preparation of its derivatives, as well sheds the light on the most common reactions of 1H-indole-3-carboxaldhyde derivatives and exploitation of these derivatives as the blocks of many biologically active compounds. Keywords: 1H-Indole-3-carboxaldehyde, Synthesis, Reactions, Heterocycles. Introduction depressant (α-methyl-tryptamine)[4], antimicrobial (phytoalexins brassinin and cyclobrassinin) 1H-Indole-3-carboxaldhyde (I3C, 1) is a [5,6], antiviral (chondramide A) [7], anthelmintic natural compound found in tomato seedling, pea (chondriamide C) [8], monoamine oxidase inhibitor seedling, barley, lupine, cabbage and cotton [1]. (aplysinopin) [9], anti-plasmodial (isocryptolepine) 1H-Indole-3-carboxaldehyde (1) represents an [10], antifungal (phytoalexine caulilexins A-C) important starting and intermediate compound [11], inhibit DNA replication and transcription for building many various synthetic and natural (cryptosanginolentine 1) [12] and muscle relaxant biologically active compounds especially with (α,β-cyclopiazonic acid)[13] activities (Fig. 1). -
Barriers to the Identification of Occupational Asthma
BARRIERS TO THE IDENTIFICATION OF OCCUPATIONAL ASTHMA By Gareth Iestyn Walters A thesis submitted to The University of Birmingham for the degree of Doctor of Medicine School of Health and Populations Sciences College of Medical and Dental Sciences The University of Birmingham August 2014 DEDICATION This is for my father Derek Walters (1940-2011)… who would have kept a copy on the bookshelf, but probably wouldn’t have read it unless it was about Frederick the Great or the Stuart monarchy… which unfortunately it isn’t. ABSTRACT Occupational asthma accounts for 1 in 6 cases of new-onset adult asthma and is associated with an estimated societal cost in the UK of £100 million per annum. The cost is somewhat avoidable if workers with occupational asthma are identified quickly and removed from exposure to a sensitizing agent. However many workers with occupational asthma go undiagnosed or experience a lengthy delay in diagnosis. The aim of this work was to identify the barriers to diagnosis of occupational asthma on the part of the worker and of the healthcare professional. The first study evaluated current practice in assessing working-age asthmatics for occupational asthma in a West Midlands primary care population, using UK national guidelines as a reference standard. The recorded prevalence of occupational asthma was much lower than expected (0-0.8%) and there was poor enquiry regarding occupation (14% of cases) and the effect of work on asthma symptoms (2% of cases) by primary healthcare professionals. The second study used a qualitative methodology to explore and define health beliefs and behaviours in workers with occupational asthma symptoms. -
Ncounter Human Inflammation V2 Panel Gene List
nCounter Human Inflammation V2 Panel Gene List Official Symbol Accession Alias / Prev Symbol GO Annotation* Official Full Name Intrinsic To Plasma Membrane,Intrinsic To Membrane,Membrane Part,Membrane,Integral To Membrane,Integral To Plasma Membrane,Plasma Membrane Part,Plasma Membrane,Signal Transduction,Cell Surface Receptor Linked Signal Transduction Go 0007166,Defense Response,Inflammatory Response,Response To Stress,Response To External AGER NM_001136.3 RAGE Stimulus,Response To W advanced glycosylation end product-specific receptor Cytoplasmic Part,Membrane,Cytoplasm,Cytosol,Plasma Membrane,Regulation Of Biological Quality,Positive Regulation Of Cell Proliferation,Cell Development,Negative Regulation Of Apoptosis,Programmed Cell Death,Regulation Of Growth,Carboxylic Acid Metabolic ALOX12 NM_000697.1 12-LOX, 12S-LOX, LOG12 Process,Fatty Acid Oxidation,Negative Regulation Of Cellular Process,Regulation Of Cell arachidonate 12-lipoxygenase Defense Response,Inflammatory Response,Response To Stress,Response To External ALOX15 NM_001140.3 15-LOX-1, 15LOX-1 Stimulus,Response To Wounding,Oxidoreductase Activity arachidonate 15-lipoxygenase ALOX5 NM_000698.2 5-LO, 5-LOX, 5LPG, LOG5 Oxidoreductase Activity arachidonate 5-lipoxygenase Extracellular Region,Extracellular Region Part,Extracellular Space,Cell Cell Signaling,Cell AREG NM_001657.2 AR, CRDGF, SDGF Proliferation Go 0008283,Receptor Binding,Growth Factor Activity amphiregulin Cytoplasm,Carboxylic Acid Metabolic Process,Glutamine Family Amino Acid Metabolic Process,Amino Acid Metabolic -
Vilsmeier-Haack Reactions in Synthesis of Heterocycles: an Overview
Chapter 2 Vilsmeier-Haack reactions in Synthesis of Heterocycles: An Overview 2.1 Introduction In 1927 Vilsmeier and Haack observed that N-methylformanilide 1 can formylate aniline derivatives in the presence of POCl3. Later the reaction was extended using simple formamide derivatives like N,N- dimethylformamide, N-formylpiperidine, N-formylmorpholine etc. to formylate electron rich aromatic and aliphatic substrates, and these types of reactions are known as Vilsmeier-Haack reactions.2 A Vilsmeier- Haack reagent 3 is produced when a disubstituted formamide or amide, typically N,N-dimethylformamide (DMF) 1 is treated with an acid halide, frequently phosphorous oxychloride, though to a lesser extent, oxalyl chloride (Scheme 2.1). O OPOCl 2 Cl POCl H N 3 H N H N Cl OPOCl 2 1 2 3 Scheme 2.1 A large number of aromatic and aliphatic substrates, particularly the carbonyl compounds containing methyl or methylene groups adjacent to the carbonyl groups undergo iminoalkylation by the Vilsmeier-Haack reagent.2 Hydrolysis of iminium salts formed in this reaction afford aldehyde derivatives. Usually the reactions of active methylene compounds with reagents of the Vilsmeier type afford -chloromethyleneiminium salts or -chlorovinylaldehydes, which have been recognized as useful intermediates 13 in heterocyclic synthesis. An overview of important Vilsmeier-Haack formylation reactions and Vilsmeier-Haack reactions leading to heterocycles is included in this chapter. 2.2 The Vilsmeier-Haack reactions of aromatic compounds The Vilsmeier-Haack reactions of electron rich aromatic compounds, generally, afford aldehyde derivatives in good yields. For example, N,N- dimethylaniline 4 afford p-N,N-dimethylaminobenzaldehyde 6 (Scheme 2.2).2a Anthracenes, naphthalenes and other polycyclic aromatic compounds also undergo facile formylation. -
Formylation of Electron-Rich Aromatic Rings Mediated by Dichloromethyl Methyl Ether and Ticl4: Scope and Limitations
Molecules 2015, 20, 5409-5422; doi:10.3390/molecules20045409 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article Formylation of Electron-Rich Aromatic Rings Mediated by Dichloromethyl Methyl Ether and TiCl4: Scope and Limitations Iván Ramos-Tomillero 1,2, Marta Paradís-Bas 1,2, Ibério de Pinho Ribeiro Moreira 3,4, Josep María Bofill 2,4, Ernesto Nicolás 2,5,* and Fernando Albericio 1,2,6,7,8,* 1 Institute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain; E-Mails: [email protected] (I.R.-T.); [email protected] (M.P.-B.) 2 Deparment of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain; E-Mail: [email protected] 3 Department of Physical Chemistry, University of Barcelona, Barcelona 08028, Spain; E-Mail: [email protected] 4 Institut de Química Teòrica i Computacional (IQTCUB), University of Barcelona, Barcelona 08028, Spain 5 Institut de Biomedicina (IBUB), University of Barcelona, Barcelona 08028, Spain 6 CIBER-BBN, Barcelona 08028, Spain 7 School of Chemistry, University of KwaZulu-Natal, Durban 4000, South Africa 8 School of Chemistry, Yachay Tech, Yachay City of Knowledge, Urcuqui 100119, Ecuador * Authors to whom correspondence should be addressed; E-Mails: [email protected] (E.N.); [email protected] or [email protected] (F.A.); Tel.: +34-93-403-7088 (F.A.). Academic Editor: Jean Jacques Vanden Eynde Received: 27 January 2015 / Accepted: 12 March 2015 / Published: 26 March 2015 Abstract: Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. -
Modification of Chitosan for Simultaneous Antioxidant
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by ScholarBank@NUS MODIFICATION OF CHITOSAN FOR SIMULTANEOUS ANTIOXIDANT AND ANTIBACTERIAL FUNCTIONS CHEN FEI NATIONAL UNIVERSITY OF SINGAPORE 2009 MODIFICATION OF CHITOSAN FOR SIMULTANEOUS ANTIOXIDANT AND ANTIBACTERIAL FUNCTIONS CHEN FEI (B. ENG ECUST) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2009 ACKNOWLEDGEMENT Studying for a degree is a huge process that evolves over time and involves many role players, some of whom do not even realize the part they have played. I owe a huge debt to my supervisor Prof. Neoh Koon Gee, who gave me confidence and guidance to persist in my research works. I also want to express my thanks to my colleagues, Dr. Shi Zhilong, Chua Poh Hui, Tan Lihan, Zhang Fan and Lim Siew Lay. Discussing and talking with them have always inspired me on my research work. Finally, I would like to appreciate the financial support from the National University of Singapore. i TABLE OF CONTENTS ACKNOWLEDGEMENT i TABLE OF CONTENTS ii SUMMARY vi NOMENCLATURE viii LIST OF FIGURES ix LIST OF SCHEMES x LIST OF TABLES xi 1 Introduction 1 2 Literature review 5 2.1 Chitosan 5 2.1.1 Sources of chitosan 5 2.1.2 Chemistry of chitosan 7 2.1.3 Biological properties of chitosan 9 2.1.4 Applications of chitosan 11 2.2 Ascorbic acid 14 2.3 Essential oils 15 2.3.1 Major components of essential oils 15 2.3.2 Antibacterial activity of essential oils 16 2.3.3 -
Amino Acid-Based Polymeric Scaffold Fabrication And
AMINO ACID-BASED POLYMERIC SCAFFOLD FABRICATION AND MODIFICATION FOR BONE REGENERATION APPLICATIONS A Dissertation Presented to The Graduate Faculty of The University of Akron In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Shan Li May, 2018 i AMINO ACID-BASED POLYMERIC SCAFFOLD FABRICATION AND MODIFICATION FOR BONE REGENERATION APPLICATIONS Shan Li Dissertation Approved: Accepted: Advisor Department Chair Dr. Matthew L Becker Dr. Coleen Pugh Committee Member Dean of the College Dr. Yu Zhu Dr. Eric J. Amis Committee Member Dean of the Graduate School Dr. Darrell H. Reneker Dr. Chand Midha Committee Member Date Dr. Toshikazu Miyoshi Committee Member Dr. Rebecca Kuntz Willits ii ABSTRACT Bone tissue engineering has evolved into an inter-disciplinary field of chemistry, engineering, and biology to regenerate defective tissues or organs since its emergence. Polymeric scaffolds represent one of the key components in bone tissue engineering and are widely used due to the low cost, unlimited supply, biointegrity, biodegradability, bioresorbability, tunable mechanical properties, non-toxicity and processability. It is designed to act as a 3D template to provide mechanical support and guide cells to form new tissue by mimicking ECM. Amino acid based poly(ester urea)s (PEUs) are high modulus, biodegradable, and non-toxic thermoplastic polymers, which have been synthesized and characterized by the Becker lab for their applications in tissue engineering. However, their inherent radiolucent and bioinert properties limit clinical application. Efforts have been made to modify PEUs with radiopacity for in vivo detection with X-rays and osteoinductivity via growth factor delivery for bone inducement. The advances in new technologies bring 3D printing to the scaffold fabrication. -
An Investigation of the Properties of Mixtures of Starches with Mono-Myristic Acid Triglyceride As Potential Selectively Digestible Films
An Investigation of the Properties of Mixtures of Starches with Mono-Myristic Acid Triglyceride as Potential Selectively Digestible Films. A dissertation submitted for the degree of Doctor of Philosophy by Christiane Charlotte Fertig at The School of Pharmacy Faculty of Medicine University of London October 2002 ProQuest Number: 10104897 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest. ProQuest 10104897 Published by ProQuest LLC(2016). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. Microform Edition © ProQuest LLC. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 Abstract Abstract The aim of this work was the production of melt-films based on a mixture of unprocessed starch and a mono-myristic acid triglyceride for use as a coating on colon delivery formulations. The starches were embedded in the triglyceride-matrix during a melting process and drug release across the films was obtained by the digestion of the starch fraction through colonic a-amylases. During the first part of this study, the physicochemical properties of 7 starches, whose amylose content ranged from 0 % to nearly 100 %, were investigated and sub sequently correlated by statistical analysis. The second part comprised the identification of the optimum film formula with respect to film-forming temperature, starch content and film thickness. -
Vilsmeier-Haack Reagent
Current Chemistry Letters 2 (2013) 187–196 Contents lists available at Growing Science Current Chemistry Letters homepage: www.GrowingScience.com/ccl Vilsmeier-Haack reagent: A facile synthesis of 2-(4-chloro-3,3-dimethyl-7- phenoxyindolin-2-ylidene)malonaldehyde and transformation into different heterocyclic compounds Laya Roohia, Arash Afghanb* and Mehdi M. Baradarania aDepartment of Chemistry, Faculty of Science, University of Urmia, Urmia 57153-165, Iran bDepartment of Chemical Engineering, Urmia University of Technology, Urmia 57155-419, Iran C H R O N I C L E A B S T R A C T Article history: 2-(5-Chloro-2-phenoxyphenyl)hydrazine was converted to corresponding 3H-indole by Fischer Received March 20, 2013 method utilizing the isopropyl methyl ketone in acetic acid. The reaction of 3H-indole with Received in Revised form Vilsmeier-Haack reagent furnished aminomethylene malonaldehyde in excellent yield while the July 7, 2013 reactions of malonaldehyde with hydrazine, arylhydrazines, amines, cyanoacetamide and Accepted 28 July 2013 hydroxylamine hydrochloride, led to the corresponding pyrazole derivatives, enamines, Available online cyanopyridone, and cyanoacetamide derivatives respectively. 30 July 2013 Keywords: Vilsmeier-Haack reagent Fischer indole synthesis malonaldehydes pyrazoles enamines cyanoacetamide cyanopyridone © 2013 Growing Science Ltd. All rights reserved. 1. Introduction Chloromethyleneiminium salts, commonly known as highly versatile Vilsmeier-Haack reagent,1 usually generated in situ by the treatment of POCl3 with an N,N-disubstituted formamides (e.g., DMF), is very useful in the synthetic transformations. Selected applications of this reagent include: formylation,2,3 cyclohaloaddition,4 cyclization5 and ring annulations.6 A wide variety of alkene derivatives,7 carbonyl compounds,8 activated methyl and methylene groups bearing chemicals,9 and oxygen10 as well as nitrogen nucleophiles11 undergo the reactions with Vilsmeier reagent to yield the corresponding iminium salts. -
Matériaux Moléculaires Magnétiques À Base De Porphyrines Emel Önal
Matériaux moléculaires magnétiques à base de porphyrines Emel Önal To cite this version: Emel Önal. Matériaux moléculaires magnétiques à base de porphyrines. Material chemistry. Univer- sité Claude Bernard - Lyon I, 2014. English. NNT : 2014LYO10103. tel-01214515 HAL Id: tel-01214515 https://tel.archives-ouvertes.fr/tel-01214515 Submitted on 15 Oct 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 1XPHURG¶RUGUH $QQHH ŕʼnņŔņġŅņġō’ŖŏŊŗņœŔŊŕņġťŦġōŚŐŏġ ņŏġńŐŕŖŕņōōņġłŗņńġ ňņŃśņġŊŏŔŕŊŕŖŕņġŐŇġŕņńʼnŏŐōŐňŚġ ņńŐōņġŅŐńŕŐœłōņġŅņġńʼnŊŎŊņġ MOLECULAR MAGNETIC MATERIALS BASED ON PORPHYRIN MACROCYCLES VRXWHQXH SXEOLTXHPHQW OH -XLQ SDU 0(PHOgQDO JURY Mustafa Bulut Makoto Handa Catherine Hirel Dominique Luneau T.R. GEBZE INSTITUTE of TECHNOLOGY GRADUATE SCHOOL of ENGINEERING and SCIENCES MOLECULAR MAGNETIC MATERIALS BASED ON PORPHYRIN MACROCYCLES EMEL ÖNAL A THESIS SUBMITTED for THE DEGREE of DOCTOR of PHILOSOPHY CHEMISTRY DEPARTMENT GEBZE 2014 T.R. GEBZE INSTITUTE of TECHNOLOGY GRADUATE SCHOOL of ENGINEERING and SCIENCES MOLECULAR MAGNETIC MATERIALS BASED ON PORPHYRIN MACROCYCLES EMEL ÖNAL A THESIS SUBMITTED for THE DEGREE of DOCTOR of PHILOSOPHY CHEMISTRY DEPARTMENT THESIS SUPERVISOR ASST. PROF. DR. CATHERINE HIREL GEBZE 2014 SUMMARY The preparation of Molecule-Based Magnets is based on the assembling carriers of magnetic moment. These may be the metal ions only with diamagnetic linkers or the metal ions connected through open-shell organic molecule.