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British Heart Foundation Research Grant Awards 2006/2007 Contents British Heart Foundation Research Grant Awards 2006/2007 Contents Introduction 1 BHF chairholders 2 Awards made during the year 1 April 2006 – 31 March 2007 6 Fellowships 6 Programme Grant renewals 14 Programme Grants 15 Infrastructure Grant 15 Project Grants 16 Analysis of funding of Project Grants 28 British Heart Foundation Research Grant Awards 2006/2007 Introduction In the year April 2006 to March 2007 the BHF collaborates with other grant-giving British Heart Foundation (BHF) awarded bodies to ensure maximum gain for grants totalling over £50 million for research cardiovascular research. For instance, it into the causes, prevention, diagnosis made a contribution of £1.25 million towards and treatment of diseases of the heart the National Prevention Research Initiative, and circulation. a collaboration with the Medical Research Council (MRC), Cancer Research UK (CRUK) The BHF has three research grant committees and several other health charities, to support which meet four or more times a year. The high-quality research into primary prevention members of each committee are experts of cancer, coronary heart disease and in various aspects of basic and clinical diabetes. It also committed £6 million to cardiovascular research. Applications are a UK-wide competition for clinical research sent to independent reviewers before being infrastructure facilities announced under assessed by the committee. Judgements the banner of the UK Clinical Research are made on factors such as scientific Collaboration (UKCRC) involving contributions merit, relevance to cardiovascular disease, from the MRC, Wellcome Trust, CRUK, timeliness, relationship to other work in the The Wolfson Foundation and the UK field, and value for money. Approximately Departments of Health. one third of applications are successful. BHF, as a member of the consortium of A breakdown of expenditure for each of the major UK biomedical and health research three research committees is approximately funders, has also contributed £250,000 to as follows. The Chairs and Programme the funding of UK PubMed Central (UKPMC), Grants Committee awarded £15 million, with the intention of ensuring that complete £6.7 million of which is the annual cost of versions of publications derived from maintaining BHF chairholders’ core funding. their funded research are available freely. There were 29 chairholders (also referred UKPMC was launched on 8 January 2007. to as BHF Professors) in post during the year and they are site-visited every five The pages that follow list BHF chairholders years to assess past and future research in post during the year and new awards performance and plans. The visiting team made for Fellowships, Programme Grants, includes internationally renowned scientists. Project Grants and other awards. With its revamped schemes, the Fellowships Committee awarded 87 applications for Full details of all types of awards offered personal awards costing £14 million. The by BHF and the application process appear Project Grants Committee awarded 154 on the BHF website bhf.org.uk/research. applications to the value of £23 million. British Heart Foundation Research Grant Awards 2006/2007 Introduction 1 BHF chairholders Listed by town University of Birmingham University of Cambridge The Chair of Cardiovascular Medicine The Chair of Cardiovascular Sciences Held by: Professor M P Frenneaux MBBS MD Held by: Professor M R Bennett BSc MB ChB FRACP FACC FRCP FESC MA PhD FRCP FAHA FMedSci Major interests: Novel medical treatments for Major interest: The molecular mechanisms heart failure; using pacemakers to ameliorate controlling smooth muscle cell proliferation, heart failure and improve cardiac function in ageing and death in atherosclerosis. hypertrophic cardiomyopathy; links between depression and heart disease. University of Cambridge University of Birmingham The Chair of Cardiac Surgery Held by: Professor B R Rosengard MD FRCS The Chair of Cardiovascular Sciences FACS – resigned 3 September 2006 and Cellular Pharmacology Major interest: The control of chronic rejection Held by: Professor S P Watson BSc PhD in transplanted organs. FMedSci Major interest: The cell and molecular University of Cardiff biology of blood platelets in haemostasis and thrombosis. The Sir Thomas Lewis Chair of Cardiovascular Science University of Bristol Held by: Professor A J Williams BA PhD – from 1 January 2007 The Chair of Cardiac Surgery Major interest: Molecular biology of calcium Held by: Professor G D Angelini MD MCh FRCS flux through the ryanodine receptor in cardiac Major interests: Coronary artery bypass myocytes and its disturbance in arrhythmia. surgery, including off-pump techniques and methods to reduce restenosis; improving University of Edinburgh surgery for heart defects in infants. The Duke of Edinburgh Chair of Cardiology University of Bristol Held by: Professor K A A Fox BSc MBChB FRCP FESC FMedSci The Chair of Vascular Cell Biology Major interests: Clinical trials to determine Held by: Professor A C Newby MA PhD best treatment for patients with acute Major interests: The cell and molecular coronary syndrome; novel non-invasive biology of atherosclerosis and restenosis; imaging techniques to detect coronary gene therapy. vascular disease. British Heart Foundation Research Grant Awards 2006/2007 BHF chairholders 2 University of Glasgow University of Leicester The Walton Chair of Medical Cardiology The Chair of Cardiology Held by: Professor S M Cobbe MA MD FRCP Held by: Professor N J Samani BSc MD FRCP FESC FRSE FMedSci FACC FMedSci Major interests: Mechanisms underlying Major interests: Genetics of hypertension arrhythmia and sudden death; enhancing and coronary heart disease; cell ageing success rates for resuscitation following mechanisms and premature cardiovascular cardiac arrest in the community. disease. University of Glasgow University of London Imperial College (Hammersmith) The Chair of Cardiovascular Medicine Held by: Professor A F Dominiczak OBE MD The Sir John McMichael Chair of FRCP FAHA FRSE FMedSci Cardiovascular Medicine Major interest: Genetic analysis to Held by: Professor D O Haskard DM FRCP understand molecular mechanisms leading FMedSci to hypertension. Major interest: Cellular and molecular control of inflammatory and immune processes in University of Glasgow atherosclerosis. The Chair of Cardiac Surgery University of London Supported by the Isidore and David Imperial College (Hammersmith) Walton Charitable Trust Held by: Professor D J Wheatley MD ChM The Chair of Cardiothoracic Surgery FRCSEd FRCS(Glasg) FRCPEd FMedSci – Held by: Professor K M Taylor MD FRCS FRCSE retired 30 September 2006 FESC FETCS FSA Major interest: Design and development of Major interests: Improving cardiopulmonary novel replacement heart valves. bypass techniques; maintaining national registries for audit of heart surgery outcomes. University of Leeds The Chair of Cardiology Held by: Professor S G Ball MA MB BChir PhD FRCP Major interests: Genetics of coronary heart disease; cardiac MRI. British Heart Foundation Research Grant Awards 2006/2007 BHF chairholders 3 University of London University of London Imperial College (NHLI) King’s College London The Simon Marks Chair of Cardiology The John Parker Chair of Held by: Professor P A Poole-Wilson MD FRCP Cardiovascular Sciences FACC FESC FMedSci Held by: Professor Q Xu MD PhD Major interest: Clinical trials of novel medical Major interest: The cell and molecular treatments for heart failure. biology of stem cells and their importance in modulating atherosclerosis and restenosis. University of London Imperial College (NHLI) University of London St George’s The Chair of Cardiothoracic Surgery Held by: Professor Sir Magdi Yacoub FRCS The Prudential Chair of Clinical Cardiology FMedSci FRS – retired 30 September 2006 Held by: Professor A J Camm QHP MD BSc FRCP FESC FACC FAHA FCGC C.St.J Major interests: Optimising heart transplant techniques; mechanisms of chronic graft Major interest: Mechanisms and treatment rejection; left ventricular assist devices. of atrial fibrillation. University of London University of London King’s College London University College London The Chair of Cardiology The Chair of Cardiovascular Genetics Held by: Professor A M Shah MD FRCP Held by: Professor S E Humphries BSc PhD FMedSci MRCP(Hon) FRCPath Major interests: The cell and molecular Major interests: Genetics of hyperlipidaemias; biology of production of reactive oxygen interactions between genes and species (by NADPH oxidase) in the environmental factors in the development cardiovascular system and their roles in of cardiovascular disease. atherosclerosis, cardiac hypertrophy and heart failure. University of London University College London The Chair of Cardiovascular Science Held by: Professor J F Martin MBChB MD FRCP FESC FMedSci Major interests: Gene therapy to control stenosis in grafted blood vessels; stem cell therapy for patients after myocardial infarction. British Heart Foundation Research Grant Awards 2006/2007 BHF chairholders 4 University of London University of Manchester University College London The Chair of Cardiac Physiology The Chair of Psychology Held by: Professor D A Eisner MA DPhil Held by: Professor A P A Steptoe MA DPhil FMedSci DSc FBPsS AcSS Major interest: Cell and molecular physiology Major interest: Psychological stress and of the role of calcium in control of heart rhythm. cardiovascular disease. University of Oxford University of London University College London The Chair of Medicine and Epidemiology (Institute of Child Health)
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