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UK Health Research Analysis 2018 UK Health Research Analysis 2018 UK Clinical Research Collaboration 2020 © UK Clinical Research Collaboration 2020 Published by the Medical Research Council, part of UK Research and Innovation ISBN 978-0-903730-29-7 The text of this report and supporting data (excluding images and logos) is licensed under a Creative Commons Attribution 4.0 International (CCBY 4.0) License unless otherwise stated. The Health Research Classification System itself is open source. You are free to use and distribute the HRCS but you should not alter it or use it for commercial benefit. This paper was written using data obtained on 27 September 2019, from Digital Science’s Dimensions platform, available at https://app.dimensions.ai. Access was granted to subscription-only data sources under licence agreement. Acknowledgment should include “UK Health Research Analysis 2018 (UK Clinical Research Collaboration , 2020) https://hrcsonline.net/reports/analysis-reports/uk-health-research-analysis-2018/”. Any enquiries related to this publication should be sent to: UK Clinical Research Collaboration C/O Medical Research Council, UK Research and Innovation, Polaris House, North Star Avenue, Swindon, SN2 1FL Further information is available via the HRCS website contact us page or by email at [email protected] This publication is available at: https://hrcsonline.net/reports/analysis-reports/uk-health-research-analysis-2018/ Cover images © iStockphoto 2 UK Health Research Analysis 2018 UK Clinical Research Collaboration 2020 Acknowledgements The authors would like to thank all organisations which Finally, a huge thank you to the Health Research Analysis Forum participated in this analysis, particularly those new to the (HRAF) for their support and contributions to the project, report process. Coordinating so many organisations and curation of and the HRCS as a whole. data has been a significant challenge which would have been considerably harder to manage were it not for the help of the Dr James Carter staff at each organisation in contact with us. Project Manager & HRAF Chair, MRC Evaluation Officer Particular thanks go to the Association of Medical Research Ms Emily Stevens, Charities (AMRC) for their help in compiling and submitting Project Coordinator, MRC Data Analyst data on behalf of their membership. Likewise, thanks to the individuals from the UK Strategic Coordinating Body for Health of the Public Research (SCHOPR) for their help in contacting suitable individuals across the UK Government departments. Health Research Analysis Forum 2018 James Carter (Chair) Medical Research Council, UKRI Shannon Amoils British Heart Foundation Nicola Armstrong Health and Social Care R&D Division, Public Health Agency, Northern Ireland Jonathan Best Wellcome Trust Michael Bowdery Health and Care Research Wales (R&D Division, Health and Social Services Group, Welsh Government) Martin Champion Engineering and Physical Sciences Research Council, UKRI Tammy Cheng Versus Arthritis Lynne Davies Cancer Research UK Jocelyn LeBlanc Association of Medical Research Charities Sarah Qureshi UK Clinical Research Collaboration Julie Simpson Chief Scientist Office, Scotland Emily Stevens Medical Research Council, UKRI Jola Sysak National Institute for Health Research Beverley Thomas Biotechnology and Biological Sciences Research Council, UKRI Joy Todd Economic and Social Research Council, UKRI With grateful support from Naomi Beaumont Economic and Social Research Council, UKRI Marc Boggett Health and Care Research Wales (R&D Division, Health and Social Services Group, Welsh Government) Michael Cunningham Health and Social Care R&D Division, Public Health Agency, Northern Ireland & Naomh Gallagher Rachel Conner UK Strategic Coordinating Body for Health of the Public Research Lucie Duluc British Heart Foundation Eva Garritsen Association of Medical Research Charities Joanna Jacklin Biotechnology and Biological Sciences Research Council, UKRI Annie Sanderson Wellcome Trust Ian Viney Medical Research Council, UKRI UK Health Research Analysis 2018 UK Clinical Research Collaboration 2020 3 4 UK Health Research Analysis 2018 UK Clinical Research Collaboration 2020 Contents Acknowledgements ........................................................ 3 Table of Contents .......................................................... 5 Table of Figures ........................................................... 6 Executive Summary ........................................................ 9 Introduction and Purpose of the Analysis .................................... .13 Scope of the Analysis ................................................... 15 Methods............................................................. 23 Detailed Analysis: Research Activity ........................................ 25 Detailed Analysis: Health Categories ........................................ 31 Geographical Distribution ................................................ 39 Distribution of Funding between Charity and Public Sector ....................... .45 Progress and next steps ................................................. 48 Appendix 1 Participating organisations and qualitative submissions ........................54 Appendix 2 Combined UK spend breakdown by funding organisation . 108 Appendix 3 Contributions of additional participating organisations to the 2018 analysis . 113 Appendix 4 Additional funding sources for UK health R&D expenditure.....................118 Appendix 5 Total UK health R&D expenditure .......................................122 Appendix 6 Total funding distribution by HCRS Research Activity sub-groups . 126 Appendix 7 Details of mapping between WHO DALY rates and HRCS Health Categories.........128 Appendix 8 Total funding distribution by UK geographical region (NUTS 1) including selected cities . .130 Appendix 9 Total funding distribution by organisation type; Government, UKRI or charitable . .133 Appendix 10 Changes in coding methodology and uptake of auto-coding ...................135 Appendix 11 Additional methods................................................137 UK Health Research Analysis 2018 UK Clinical Research Collaboration 2020 5 Index of Figures Figure 1 – Combined direct spend totals for UK Health Research Analysis series (2004/05 to 2018). Data from the original HRAF (12 funders) and total participating organisations (n=64 in 2014, n= 123 in 2018) are shown separately to allow comparison across time. .......................................................................................................................................... 20 Figure 2 – Distribution of estimated total UK health research expenditure for 2018 by research sector. ........................................ 22 Figure 3 – Distribution of direct health research expenditure by HRCS Research Activity in 2018 .................................................. 26 Figure 4 – Funding distribution for all contributing organisations by HRCS Research Activity across the four UK Health Research Analyses 2004/05 to 2018 ........................................................................................................................................ 28 Figure 5 – Distribution of direct health research expenditure by HRCS Health Category in 2018 .................................................... 32 Figure 6 – Funding distribution for all contributing organisations by HRCS Health Category across the four UK Health Research Analyses 2004/05 to 2018 ........................................................................................................................................ 34 Figure 7 – Comparison of Disability Adjusted Life Years (DALY) rates for the UK in 2016 and the proportion of HRCS Health Category spending in 2018 ...................................................................................................................................................... 37 Figure 8 – Map to show regional distribution of combined research funding in the UK using NUTS level 1 codes ............................ 40 Figure 9 – Funding distribution by geographical region across the UK Health Research Analysis series 2004/05 to 2018 ..................41 Figure 10 – Distribution by city of international awards made by UK-based organisations for the UK Health Research Analysis 2018 ......................................................................................................................................................... 42 Figure 11 – Comparison of HRCS Research Activity (upper panel) and Health Category (lower panel) for international funders (a combined dataset of funding data from CORDIS and Dimensions) and the UK Health Research Analysis 2018 UK-only dataset. ...................................................................................................................................................... 44 Figure 12 – Distribution of Research Activity Spend by Charity and Public funders, as a proportion of combined total expenditure in 2018..........................................................................................................................................47 Figure 13 – Breakdown of Health Category spending by Charity or Public funder, split by >£90m (upper panel) and <£90m (lower panel) ........................................................................................................................................................... 48 Figure 14 – Differences in the proportion of combined health research spend 2018 by HRCS Research Activity for all organisation
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