PROGRAM
SATURDAY, June 8—7:00 PM
SESSION 1 T CELL BIOLOGY
Chairperson: Zemin Zhang, Peking University, Beijing, China
KEYNOTE SPEAKER
Regulatory T cells in cancer Alexander Rudensky [35’+10’] Presenter affiliation: Memorial Sloan-Kettering Cancer Center / HHMI, New York, New York. 1
Induction and transcriptional regulation of "check-point" molecules Vijay K. Kuchroo [20’+10’] Presenter affiliation: Evergrande Center, Harvard Medical School, Boston, Massachusetts. 2
Dissecting the transcriptional network of CD8 T cell responses using in vivo CRISPR screening Zeyu Chen, Eri Arai, Sasikenth Manne, Omar Khan, Yuan He, Zhangying Cai, Josephine Giles, Zhendong Cao, Amy Baxter, Shin- Foong Ngiow, Zhuoyu Wen, Makoto Kurachi, Junwei Shi, E.John Wherry [10’+5’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 3
CD28null tumor-infiltrating CD8+ T cells that poorly respond to PD-1 blockade are rescued by IL-15 combination Kyung Hwan Kim, Hong Kwan Kim, Myung-Ju Ahn, Eui-Cheol Shin [10’+5’] Presenter affiliation: GSMSE, Daejeon, South Korea. 4
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SUNDAY, June 9—9:00 AM
SESSION 2 INNATE IMMUNITY AND T CELL BIOLOGY
Chairpersons: John Wherry, University of Pennsylvania, Philadelphia, Pennsylvania, USA Chen Dong, Tsinghua University, Beijing, China
KEYNOTE SPEAKER
Tumor-induced B cells and erythroblast-like cells (Ter-cells) in pre-metastatic niche formation and cancer metastasis Xuetao Cao [35’+10’] Presenter affiliation: Nankai University, Tianjin, China; Chinese Academy of Medical Sciences, Beijing, China; Second Military Medical University, Shanghai, China. 5
Identification of novel key regulators of natural killer cell activation Sebastian Carotta [20’+10’] Presenter affiliation: Boehringer Ingelheim, Vienna, Austria. 6
Coffee / Tea Break
Molecular mechanisms of T cell exhaustion and implications for immunotherapy E John Wherry [20’+10’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 7
Molecular control of T cell function in cancer Chen Dong [20’+10’] Presenter affiliation: Tsinghua University, Beijing, China. 8
VEGF-A drives a TOX-mediated T-cell exhaustion program in microsatellite stable colorectal cancer Chang Gon Kim, Mi Jang, Youngun Kim, Galam Leem, Kyung Hwan Kim, Hoyoung Lee, Tae-Shin Kim, Seong Jin Choi, Hyung-Don Kim, Ji Won Han, Jong Hoon Kim, Sang Joon Shin, Joong Bae Ahn, Kang Young Lee, Su-Hyung Park, Hoguen Kim, Byung Soh Min, Eui-Cheol Shin [10’+5’] Presenter affiliation: Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 9
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SUNDAY, June 9—2:00 PM
SESSION 3 POSTER SESSION
CD20+ B cells infiltrated in ENKTL tissues and correlated with low Ki-67 index of tumor cells Min-Min Chen, Lin-Zhi Wei, Jie-Ying Guan, Jun-Hong Fu, Ya-Yi Long, Ying-Xi Lin, Jing Li, Fang Liu, Fang Liu Presenter affiliation: Foshan University, Foshan, China. 10
Chronic 4-1BB activation impairs CD8+ T cell-mediated long term anti-tumor responses by inducing sarcoidosis in tumor-draining lymph nodes Seon-Hee Kim, Rohit Singh, SangSoo Kim, DongHoon Shin, Byoung S. Kwon, Beom K. Choi Presenter affiliation: National Cancer Center, Goyang, South Korea. 11
The effect of CCL3 to anti-tumor responses Tae Gun Kang, Hyo Jin Park, June Hyung Lee, Sang Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 12
PD-1 control over Foxp3+ regulatory T cells function in tumor microenvironment Myeong Joon Kim, Hyo Jin Park, Jimin Son, Sang-Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 13
Rab37 mediates exocytosis of Chitinase 3-like 1 in T cells to promote cancer progression I-Ying Kuo, Pei-Shan Yang, Yi-Ching Wang Presenter affiliation: National Cheng Kung University, Tainan, Taiwan. 14
Neutrophil reprogramming by lipid metabolism in lung metastasis of breast cancer Peishan Li, Guangwen Ren Presenter affiliation: The Jackson laboratory, Bar Harbor, Maine. 15
IL-27 confers a pro-tumorigenic activity of regulatory T cells via CD39 Young-Jun Park, Yeonseok Chung Presenter affiliation: BK21 Plus program, Seoul National University, Seoul, South Korea. 16
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Dominant negative PD1 armored CART cells induce remission in refractory diffuse large B cell lymphoma (DLBCL) patients Yan Yuan, Liansheng Huang, Chengfei Pu, Tianling Ding, Xibin Xiao, Zhiyuan Cao, Ting Wu, Luying Ding, He Sun, Zhao Wu, Lei Xiao, Xiaohong Zhang, Tong Chen Presenter affiliation: Innovative Cellular Therapeutics, Shanghai., China. 17
Tracking the correlation between tumor aneuploidy and immunity in intrahepatic cholangiocarcinoma Jianzhen Lin, Yang Shi, Ruibin Xi, Henghui Zhang, Haitao Zhao Presenter affiliation: Peking University, Beijing, China. 18
The IL -33/ST2 axis promotes the accumulation of regulatory T cells in the tumor microenvironment Jimin Son, Jae-Won Cho, Hyo Jin Park, Hoyoung Lee, Jeewon Lee, Sergio A. Lira, Hye Young Kim, Andrew Mckenzie, Su-Hyung Park, Eui-Cheol Shin, Insuk Lee, Sang-Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 19
A potentially T cell recruiting effect of LMO2 via regulating lactate production in solid tumors Wei Sun, Wenhao Wang Presenter affiliation: Nankai University, Tianjin, China. 20
Data-driven identification of MHC-I modulation mechanism by conventional cancer therapies Shengqing Gu, Wubing Zhang, Binbin Wang Presenter affiliation: Shanghai Pulmonary Hospital, Shanghai, China. 21
High-throughput screening for small-molecule regulators of FoxP3+Tregs function Qian Wei, Johannes Landskron, Kjetil Taskén Presenter affiliation: Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Institute for Clinical Medicine, University of Oslo, Norway. 22
CD200 is overexpressed in neuroblastoma and regulates tumor immune microenvironment Chao Xin, Han Wang, Song Gu, Min Xu, Minzhi Yin, Jingyan Tang, Xue-Feng Bai, Hua Zhu Presenter affiliation: Shanghai Children’s Medical Center, Shanghai, China. 23
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Single-cell transcriptomic analysis of immune-checkpoint resistance in hepatocellular carcinoma Zhewen Xiong, Jingying Zhou, Jianquan Cao, Yu Feng, Xuezhen Zeng, Alfred Sze-Lok Cheng Presenter affiliation: The Chinese University of Hong Kong, Hong Kong, China. 24
Galectin-9 promotes a suppressive microenvironment by enhancing STING degradation in solid tumors Chuan-xia Zhang, Jiang Li Presenter affiliation: Sun Yat-sen University Cancer Center, Guangzhou, China. 25
High activity of immune specific genes in constitutive A compartment domain Rongbin Zheng, Wubing Zhang, Xiaole Liu Presenter affiliation: School of Biology and Technology, Tongji University, Shanghai, China. 26
Tumor microenvironment (TME)-driven immune suppression in B- cell lymphoma is overcome by bromodomain inhibition Xiaohong Zhao, Fengdong Cheng, Kenneth H. Shain, Ariosto Silva, Bijal D. Shah, Eduardo M. Sotomayor, Jianguo Tao Presenter affiliation: Moffitt Cancer Center, Tampa, Florida. 27
Metabolic-immunoregulatory role of mTOR signaling in NAFLD- associated hepatocellular carcinoma Jingying Zhou, Wenshu Tang, Weiqin Yang, Yu Feng, Alfred Sze Lok Cheng Presenter affiliation: School of Biomedical Sciences, Hong Kong, Hong Kong. 28
SUNDAY, June 9—4:30 PM
Chinese Tea and Beer Tasting
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SUNDAY, June 9—7:00 PM
SESSION 4 SINGLE CELL SEQUENCING AND TUMOR IMMUNOLOGY I
Chairperson: Zemin Zhang, Peking University, Beijing, China
Dynamic properties of tumor-infiltrating immune cells revealed by single cell sequencing Qiming Zhang, Yao He, Lei Zhang, Ziyi Li, Zemin Zhang [20’+10’] Presenter affiliation: Peking University, Beijing, China. 29
Re-wiring inter-cellular interactions in colon cancer Woong-Yang Park, Hae-Ock Lee [20’+10’] Presenter affiliation: Samsung Medical Center, Seoul, South Korea. 30
Reconstructing the human immune system using single cell technologies Muzlifah A. Haniffa [20’+10’] Presenter affiliation: Newcastle University, Newcastle Upon Tyne, United Kingdom. 31
Single-cell RNA sequencing unveils diverse tumor microenvironment of early-stage lung adenocarcinomas harboring EGFR mutations Di He, Di Wang, Wei Jiang, Peng Zhang, Guoping Fan, Xianmin Zhu [10’+5’] Presenter affiliation: Tongji University, Shanghai, China. 32
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer Lei Zhang, Xin Yu, Liangtao Zheng, Yuanyuan Zhang, Wenjun Ouyang, Zemin Zhang [10’+5’] Presenter affiliation: Peking University, Beijing, China. 33
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MONDAY, June 10—9:00 AM
SESSION 5 TUMOR MICROENVIRONMENT
Chairpersons: Shannon Turley, Genentech, South San Francisco, California, USA Hai Qi, Tsinghua University, Beijing, China
Imaging immunity in many colors and dimensions—Developing a detailed spatiotemporal understanding of host defense Ronald N. Germain, Chen Zhao, Tim Laemmermann, Stefan Uderhardt, Weizhe Li, Antonio Pires da Silva, Weiming Yu, Evelyn Kandov, Nishant Thakur, Andrea Radtke [20’+10’] Presenter affiliation: Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Maryland. 34
DGKA mediates resistance to PD-1 blockade Penghui Zhou [20’+10’] Presenter affiliation: Sun Yat-Sen University Cancer Center, Guangzhou, China. 35
Selective depletion of virus-specific CD8 T cells in the liver by anti-PD-1 antibody mediated effector function during chronic infection Masao Hashimoto, Hyun-Tak Jin, Koichi Araki, Tahseen N. Nasti, Junghwa Lee, Bogumila T. Konieczny, Rajesh M. Valanparambil, Jeffrey V. Ravetch, Gordon J. Freeman, Rafi Ahmed [10’+5’] Presenter affiliation: Emory University School of Medicine, Atlanta, Georgia. 36
Coffee / Tea Break
Inflammatory tissue tropism of virtual memory T cells enables an extra-lymphoid primary response Shiyue Hou, Tiange Shao, Tianyang Mao, Jingwen Shi, Miao Mei, Xu Tan, Hai Qi [20’+10’] Presenter affiliation: Tsinghua University, Beijing, China. 37
Biology at true resolution—Resolving complex biology with single cell analysis Joseph Aman [20’+10’] Presenter affiliation: 10x Genomics, Asia Pacific. 38
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Breast cancer cells release miR-125b in extracellular vesicles to activate fibroblasts in the tumor microenvironment Luyen T. Vu, Boya Peng, Daniel X. Zhang, William C. Cho, Judy Lieberman, Minh T. Le [10’+5’] Presenter affiliation: City University of Hong Kong, Kowloon, Hong Kong. 39
MONDAY, June 10—1:30 PM
Visit to Old Suzhou
MONDAY, June 10—7:00 PM
SESSION 6 SINGLE CELL SEQUENCING AND TUMOR IMMUNOLOGY II
Chairperson: Shyam Prabhakar, Genome Institute of Singapore, Singapore
Dissecting the mechanisms of IO therapies by single cell RNAseq Wenjun Ouyang [20’+10’] Presenter affiliation: Amgen Inc, South San Francisco, California. 40
Algorithms for single cell analysis of immune cells Shyam Prabhakar [20’+10’] Presenter affiliation: Genome Institute of Singapore, Singapore. 41
Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma Hanjie Li, Anne Leun, Ido Yofe, Yaniv Lubling, Amos Tanay, Ton Schumacher, Ido Amit [10’+5’] Presenter affiliation: Weizmann Institute, Rehovot, Israel. 42
Single-cell RNA-Seq reveals Cd38+ naïve B cells associated with better prognosis of HCC Jian He, Yingxin Lin, Xianbin Su, Qing Luo, Shila Ghazanfar, Jean Yang, Ze-guang Han [10’+5’] Presenter affiliation: Shanghai Center for Systems Biomedicine, Shanghai, China. 43
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A framework for real-time analysis and visualization of large single-cell RNA-seq data Boxi Kang, Chenwei Li, Zedao Liu, Xuze Ren, Zemin Zhang [10’+5’] Presenter affiliation: Peking University, Beijing, China. 44
TUESDAY, June 11—9:00 AM
SESSION 7 FROM MECHANISMS TO IMMUNOTHERAPIES
Chairperson: Ira Mellman, Genentech, San Francisco, California, USA
Mechanistic basis of cancer immunotherapy Ira Mellman [35’+10’] Presenter affiliation: Genentech, San Francisco, California. 45
Tumor-targeting immunotherapy—Enhanced anti-tumor efficacy with reduced toxicity Yang-Xin Fu [20’+10’] Presenter affiliation: UT Southwestern Medical Center, Dallas, Texas. 46
Anti-tumor immunity controlled through mRNA m6A program Meng Michelle Xu [20’+10’] Presenter affiliation: Tsinghua University, Beijing, China. 47
Development of combination immunotherapy for liver cancer by coordinated activation of innate and adaptive immunity Gen-Sheng Feng [20’+10’] Presenter affiliation: UCSD, La Jolla, California. 48
Enhancing the efficacy of hepatocellular carcinoma immunotherapy by specific inhibition of histone deacetylase 8 Yu Feng, Weiqin Yang, Jingying Zhou, Otto Cheung, Zhiwei Chen, Kevin Yip, Ka-Fai To, Alfred Cheng [10’+5’] Presenter affiliation: The Chinese University of Hong Kong, Hong Kong. 49
Intra-tumoral delivery of IL-27 using adeno-associated virus stimulates anti-tumor immunity and enhances the efficacy of anti- PD-1 therapy Miao Ding, Aiyan Hu, Jianmin Zhu, Jin-Qing Liu, Xue-Feng Bai [10’+5’] Presenter affiliation: Shanghai Jiao Tong University School of Medicine, Shanghai, China. 50
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TUESDAY, June 11—2:00 PM
SESSION 8 NEOANTIGENS AND T CELL THERAPIES
Chairperson: Eric Tran, Providence Cancer Institute, Portland, Oregon, USA
Targeting cancer neoantigens with T-cell transfer therapy Eric Tran [20’+10’] Presenter affiliation: Providence Cancer Institute, Portland, Oregon. 51
Evaluation of BiTE® antibody constructs in hematological malignancies and solid tumors Tara L. Arvedson [20’+10’] Presenter affiliation: Amgen, South San Francisco, California. 52
Cell-specific metabolic models reveal targets that mitigate pathogenicity in T helper cells Allon S. Wagner, Chao Wang, David Detomaso, Johannes Fessler, James Kaminsi, Julian A. Pacheco, Clary Clish, Aviv Regev, Vijay K. Kuchroo, Nir Yosef [20’+10’] Presenter affiliation: University of California, Berkeley, Berkeley, California. 53
Coffee / Tea Break
Using BCR/TCR diversity evaluates immune system and directs immune cell therapy Zhixin Zhang [20’+10’] Presenter affiliation: Sichuan University, Chengdu, China. 54
Characterization of HLA-A0201+ restricted neoantigens derived from hotspot mutations in non small cell lung cancer Asma Khanniche, Hao Ye, Yaozhou Shi, Ying Wang, Guoping Zhao [10’+5’] Presenter affiliation: Shenzhen Institutes of Advanced Technology, Shenzhen, China; Shanghai Jiao Tong University, Shanghai, China. 55
Mechano-chemical coupling regulates TCR antigen recognition Wei Chen [10’+5’] Presenter affiliation: Zhejiang University, Hang Zhou, China. 56
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Rab37 mediates IL-6 secretion and PD-1 presentation in CD8+ T cells to promote lung cancer progression Yi-Ching Wang [10’+5’] Presenter affiliation: National Cheng Kung University, Tainan, Taiwan. 57
TUESDAY, June 11—6:00 PM
COCKTAILS and BANQUET
WEDNESDAY, June 12—9:00 AM
SESSION 9 MACROPHAGES AND DENDRITIC CELLS
Chairperson: Bing Su, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Macrophage and dendritic cell biology Florent Ginhoux [20’+10’] Presenter affiliation: Agency for Science, Technology and Research, Singapore; Shanghai JiaoTong University School of Medicine, Shanghai, China. 58
Tumor-site immune modulation—Target discovery for next- generation cancer immunotherapy Jun Wang [20’+10’] Presenter affiliation: Yale University, New Haven, Connecticut. 59
Targeting mTOR complex for anti-tumor growth and immunity Bing Su, Liufu Deng, Jingsi Jin, Yuanyang Yuan, Chao Yang [20’+10’] Presenter affiliation: Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 60
Coffee / Tea Break
Enhancer dysregulation of myeloid-derived suppressor cells in hepatocellular carcinoma Wing Yan Law, Man Liu, Jingying Zhou, Ka Wing Cheung, Alfred Sze Lok Cheng [10’+5’] Presenter affiliation: The Chinese University of Hong Kong, Hong Kong. 61
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Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma Alfred S. Cheng [10’+5’] Presenter affiliation: The Chinese University of Hong Kong, Hong Kong. 62
Improving liver cancer immunotherapy by co-targeting monocytic myeloid-derived suppressor cells (M-MDSCs) Xiaoyu Liu, Jingying Zhou, Man Liu, Alfred Sze-Lok Cheng [10’+5’] Presenter affiliation: The Chinese University of Hong Kong, Hong Kong SAR, China. 63
The blockade of S100A4 in tumor-associated macrophage (TAM) delayed tumor relapse after chemotherapy Shuangqing Liu, Yanan Li, Huilei Zhang, Zhihai Qin [10’+5’] Presenter affiliation: Chinese Academy of Sciences, Beijing, China. 64
Closing Remarks
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