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Vii PROGRAM SATURDAY, June 8—7:00 PM SESSION 1 T CELL PROGRAM SATURDAY, June 8—7:00 PM SESSION 1 T CELL BIOLOGY Chairperson: Zemin Zhang, Peking University, Beijing, China KEYNOTE SPEAKER Regulatory T cells in cancer Alexander Rudensky [35’+10’] Presenter affiliation: Memorial Sloan-Kettering Cancer Center / HHMI, New York, New York. 1 Induction and transcriptional regulation of "check-point" molecules Vijay K. Kuchroo [20’+10’] Presenter affiliation: Evergrande Center, Harvard Medical School, Boston, Massachusetts. 2 Dissecting the transcriptional network of CD8 T cell responses using in vivo CRISPR screening Zeyu Chen, Eri Arai, Sasikenth Manne, Omar Khan, Yuan He, Zhangying Cai, Josephine Giles, Zhendong Cao, Amy Baxter, Shin- Foong Ngiow, Zhuoyu Wen, Makoto Kurachi, Junwei Shi, E.John Wherry [10’+5’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 3 CD28null tumor-infiltrating CD8+ T cells that poorly respond to PD-1 blockade are rescued by IL-15 combination Kyung Hwan Kim, Hong Kwan Kim, Myung-Ju Ahn, Eui-Cheol Shin [10’+5’] Presenter affiliation: GSMSE, Daejeon, South Korea. 4 vii SUNDAY, June 9—9:00 AM SESSION 2 INNATE IMMUNITY AND T CELL BIOLOGY Chairpersons: John Wherry, University of Pennsylvania, Philadelphia, Pennsylvania, USA Chen Dong, Tsinghua University, Beijing, China KEYNOTE SPEAKER Tumor-induced B cells and erythroblast-like cells (Ter-cells) in pre-metastatic niche formation and cancer metastasis Xuetao Cao [35’+10’] Presenter affiliation: Nankai University, Tianjin, China; Chinese Academy of Medical Sciences, Beijing, China; Second Military Medical University, Shanghai, China. 5 Identification of novel key regulators of natural killer cell activation Sebastian Carotta [20’+10’] Presenter affiliation: Boehringer Ingelheim, Vienna, Austria. 6 Coffee / Tea Break Molecular mechanisms of T cell exhaustion and implications for immunotherapy E John Wherry [20’+10’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 7 Molecular control of T cell function in cancer Chen Dong [20’+10’] Presenter affiliation: Tsinghua University, Beijing, China. 8 VEGF-A drives a TOX-mediated T-cell exhaustion program in microsatellite stable colorectal cancer Chang Gon Kim, Mi Jang, Youngun Kim, Galam Leem, Kyung Hwan Kim, Hoyoung Lee, Tae-Shin Kim, Seong Jin Choi, Hyung-Don Kim, Ji Won Han, Jong Hoon Kim, Sang Joon Shin, Joong Bae Ahn, Kang Young Lee, Su-Hyung Park, Hoguen Kim, Byung Soh Min, Eui-Cheol Shin [10’+5’] Presenter affiliation: Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 9 viii SUNDAY, June 9—2:00 PM SESSION 3 POSTER SESSION CD20+ B cells infiltrated in ENKTL tissues and correlated with low Ki-67 index of tumor cells Min-Min Chen, Lin-Zhi Wei, Jie-Ying Guan, Jun-Hong Fu, Ya-Yi Long, Ying-Xi Lin, Jing Li, Fang Liu, Fang Liu Presenter affiliation: Foshan University, Foshan, China. 10 Chronic 4-1BB activation impairs CD8+ T cell-mediated long term anti-tumor responses by inducing sarcoidosis in tumor-draining lymph nodes Seon-Hee Kim, Rohit Singh, SangSoo Kim, DongHoon Shin, Byoung S. Kwon, Beom K. Choi Presenter affiliation: National Cancer Center, Goyang, South Korea. 11 The effect of CCL3 to anti-tumor responses Tae Gun Kang, Hyo Jin Park, June Hyung Lee, Sang Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 12 PD-1 control over Foxp3+ regulatory T cells function in tumor microenvironment Myeong Joon Kim, Hyo Jin Park, Jimin Son, Sang-Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 13 Rab37 mediates exocytosis of Chitinase 3-like 1 in T cells to promote cancer progression I-Ying Kuo, Pei-Shan Yang, Yi-Ching Wang Presenter affiliation: National Cheng Kung University, Tainan, Taiwan. 14 Neutrophil reprogramming by lipid metabolism in lung metastasis of breast cancer Peishan Li, Guangwen Ren Presenter affiliation: The Jackson laboratory, Bar Harbor, Maine. 15 IL-27 confers a pro-tumorigenic activity of regulatory T cells via CD39 Young-Jun Park, Yeonseok Chung Presenter affiliation: BK21 Plus program, Seoul National University, Seoul, South Korea. 16 ix Dominant negative PD1 armored CART cells induce remission in refractory diffuse large B cell lymphoma (DLBCL) patients Yan Yuan, Liansheng Huang, Chengfei Pu, Tianling Ding, Xibin Xiao, Zhiyuan Cao, Ting Wu, Luying Ding, He Sun, Zhao Wu, Lei Xiao, Xiaohong Zhang, Tong Chen Presenter affiliation: Innovative Cellular Therapeutics, Shanghai., China. 17 Tracking the correlation between tumor aneuploidy and immunity in intrahepatic cholangiocarcinoma Jianzhen Lin, Yang Shi, Ruibin Xi, Henghui Zhang, Haitao Zhao Presenter affiliation: Peking University, Beijing, China. 18 The IL -33/ST2 axis promotes the accumulation of regulatory T cells in the tumor microenvironment Jimin Son, Jae-Won Cho, Hyo Jin Park, Hoyoung Lee, Jeewon Lee, Sergio A. Lira, Hye Young Kim, Andrew Mckenzie, Su-Hyung Park, Eui-Cheol Shin, Insuk Lee, Sang-Jun Ha Presenter affiliation: Yonsei University, Seoul, South Korea. 19 A potentially T cell recruiting effect of LMO2 via regulating lactate production in solid tumors Wei Sun, Wenhao Wang Presenter affiliation: Nankai University, Tianjin, China. 20 Data-driven identification of MHC-I modulation mechanism by conventional cancer therapies Shengqing Gu, Wubing Zhang, Binbin Wang Presenter affiliation: Shanghai Pulmonary Hospital, Shanghai, China. 21 High-throughput screening for small-molecule regulators of FoxP3+Tregs function Qian Wei, Johannes Landskron, Kjetil Taskén Presenter affiliation: Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Institute for Clinical Medicine, University of Oslo, Norway. 22 CD200 is overexpressed in neuroblastoma and regulates tumor immune microenvironment Chao Xin, Han Wang, Song Gu, Min Xu, Minzhi Yin, Jingyan Tang, Xue-Feng Bai, Hua Zhu Presenter affiliation: Shanghai Children’s Medical Center, Shanghai, China. 23 x Single-cell transcriptomic analysis of immune-checkpoint resistance in hepatocellular carcinoma Zhewen Xiong, Jingying Zhou, Jianquan Cao, Yu Feng, Xuezhen Zeng, Alfred Sze-Lok Cheng Presenter affiliation: The Chinese University of Hong Kong, Hong Kong, China. 24 Galectin-9 promotes a suppressive microenvironment by enhancing STING degradation in solid tumors Chuan-xia Zhang, Jiang Li Presenter affiliation: Sun Yat-sen University Cancer Center, Guangzhou, China. 25 High activity of immune specific genes in constitutive A compartment domain Rongbin Zheng, Wubing Zhang, Xiaole Liu Presenter affiliation: School of Biology and Technology, Tongji University, Shanghai, China. 26 Tumor microenvironment (TME)-driven immune suppression in B- cell lymphoma is overcome by bromodomain inhibition Xiaohong Zhao, Fengdong Cheng, Kenneth H. Shain, Ariosto Silva, Bijal D. Shah, Eduardo M. Sotomayor, Jianguo Tao Presenter affiliation: Moffitt Cancer Center, Tampa, Florida. 27 Metabolic-immunoregulatory role of mTOR signaling in NAFLD- associated hepatocellular carcinoma Jingying Zhou, Wenshu Tang, Weiqin Yang, Yu Feng, Alfred Sze Lok Cheng Presenter affiliation: School of Biomedical Sciences, Hong Kong, Hong Kong. 28 SUNDAY, June 9—4:30 PM Chinese Tea and Beer Tasting xi SUNDAY, June 9—7:00 PM SESSION 4 SINGLE CELL SEQUENCING AND TUMOR IMMUNOLOGY I Chairperson: Zemin Zhang, Peking University, Beijing, China Dynamic properties of tumor-infiltrating immune cells revealed by single cell sequencing Qiming Zhang, Yao He, Lei Zhang, Ziyi Li, Zemin Zhang [20’+10’] Presenter affiliation: Peking University, Beijing, China. 29 Re-wiring inter-cellular interactions in colon cancer Woong-Yang Park, Hae-Ock Lee [20’+10’] Presenter affiliation: Samsung Medical Center, Seoul, South Korea. 30 Reconstructing the human immune system using single cell technologies Muzlifah A. Haniffa [20’+10’] Presenter affiliation: Newcastle University, Newcastle Upon Tyne, United Kingdom. 31 Single-cell RNA sequencing unveils diverse tumor microenvironment of early-stage lung adenocarcinomas harboring EGFR mutations Di He, Di Wang, Wei Jiang, Peng Zhang, Guoping Fan, Xianmin Zhu [10’+5’] Presenter affiliation: Tongji University, Shanghai, China. 32 Lineage tracking reveals dynamic relationships of T cells in colorectal cancer Lei Zhang, Xin Yu, Liangtao Zheng, Yuanyuan Zhang, Wenjun Ouyang, Zemin Zhang [10’+5’] Presenter affiliation: Peking University, Beijing, China. 33 xii MONDAY, June 10—9:00 AM SESSION 5 TUMOR MICROENVIRONMENT Chairpersons: Shannon Turley, Genentech, South San Francisco, California, USA Hai Qi, Tsinghua University, Beijing, China Imaging immunity in many colors and dimensions—Developing a detailed spatiotemporal understanding of host defense Ronald N. Germain, Chen Zhao, Tim Laemmermann, Stefan Uderhardt, Weizhe Li, Antonio Pires da Silva, Weiming Yu, Evelyn Kandov, Nishant Thakur, Andrea Radtke [20’+10’] Presenter affiliation: Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Maryland. 34 DGKA mediates resistance to PD-1 blockade Penghui Zhou [20’+10’] Presenter affiliation: Sun Yat-Sen University Cancer Center, Guangzhou, China. 35 Selective depletion of virus-specific CD8 T cells in the liver by anti-PD-1 antibody mediated effector function during chronic infection Masao Hashimoto, Hyun-Tak Jin, Koichi Araki, Tahseen N. Nasti, Junghwa Lee, Bogumila T. Konieczny, Rajesh M. Valanparambil, Jeffrey V. Ravetch, Gordon J. Freeman, Rafi Ahmed [10’+5’] Presenter affiliation: Emory University School of Medicine, Atlanta, Georgia. 36 Coffee / Tea Break Inflammatory tissue tropism of virtual memory T cells enables an extra-lymphoid primary response
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