The Human Project

Structural Funconal Temporal Connecvity Connecvity Connecvity

Mulmodal Integraon

Molecular Imaging New Molecular Imaging Wash U U Minn MGH The Human Functional ?

21 transient co-activation networks (U-Minn/Was U) What’s the right spaal & temporal resoluon for neuroimaging? “The Next Great American Project”

“So there is this enormous mystery waiting to be unlocked, and the Initiative will change that by giving scientists the tools they need to get a dynamic picture of the brain in action and better understand how we think and how we learn and how we remember. And that knowledge could be – will be – transformative.” ~President Obama, April 2, 2013

What’s the Right Scale? 102 105 106 107 1011

worm fly fish mouse primate

Synapses Neurons Brain 1014 1011 1/person Static Dynamic What connectome matters most?

Macro-connectome Micro-connectome (whole-brain, long-distance) (every synapse, neuron, dendrite) Resolution: 1 – 2 mm ‘voxels’ Volume reconstructed: <1 mm The NIH BRAIN Scienfic Plan

To map the circuits of the brain, measure the fluctuang paerns of electrical and chemical acvity flowing within those circuits, and understand how their interplay creates our unique cognive and behavioral capabilies.

Bending the curve with clinical

Transforming diagnoscs From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior

Transforming therapeucs From chemical imbalance to circuit dysfuncon: Treatments as circuit tuning Depression as a Brain Circuit Disorder Cognition PF MCC (attention-appraisal-action) From Mayberg

MF PF9/46 PM6 Par40 hc

MCC PCC CBT

mF9/10 na-vst thal Mood Self-awareness pACC24 state insight oF11 amg mb-vta

Salience Motivation sACC25 MEDS DBS a-ins hth bstem PF PCC Interoception Meds Cg25 Br Med Bul 65:193-207, 2003 (drive-autonomic-circadian) Arch Gen Psych 61:34-41-2004 P BS

Thank you !

Paving the Way for Prevention, Recovery, and Cure www.nimh.nih.gov Research = Hope