The Human Connectome Project
Structural Func onal Temporal Connec vity Connec vity Connec vity
Mul modal Integra on
Molecular Imaging New Molecular Imaging Wash U U Minn MGH The Human Connectome Project Human Functional Connectomes?
21 transient co-activation networks (U-Minn/Was U) What’s the right spa al & temporal resolu on for neuroimaging? “The Next Great American Project”
“So there is this enormous mystery waiting to be unlocked, and the BRAIN Initiative will change that by giving scientists the tools they need to get a dynamic picture of the brain in action and better understand how we think and how we learn and how we remember. And that knowledge could be – will be – transformative.” ~President Obama, April 2, 2013
What’s the Right Scale? 102 105 106 107 1011
worm fly fish mouse primate
Synapses Neurons Brain 1014 1011 1/person Static Dynamic What connectome matters most?
Macro-connectome Micro-connectome (whole-brain, long-distance) (every synapse, neuron, dendrite) Resolution: 1 – 2 mm ‘voxels’ Volume reconstructed: <1 mm The NIH BRAIN Scien fic Plan
To map the circuits of the brain, measure the fluctua ng pa erns of electrical and chemical ac vity flowing within those circuits, and understand how their interplay creates our unique cogni ve and behavioral capabili es.
Bending the curve with clinical neuroscience
Transforming diagnos cs From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior
Transforming therapeu cs From chemical imbalance to circuit dysfunc on: Treatments as circuit tuning Depression as a Brain Circuit Disorder Cognition PF MCC (attention-appraisal-action) From Mayberg
MF PF9/46 PM6 Par40 hc
MCC PCC CBT
mF9/10 na-vst thal Mood Self-awareness pACC24 state insight oF11 amg mb-vta
Salience Motivation sACC25 MEDS DBS a-ins hth bstem PF PCC Interoception Meds Cg25 Br Med Bul 65:193-207, 2003 (drive-autonomic-circadian) Arch Gen Psych 61:34-41-2004 P BS
Thank you !
Paving the Way for Prevention, Recovery, and Cure www.nimh.nih.gov Research = Hope