CCL17 Antibody Cat. No.: 7239
CCL17 Antibody
Immunofluorescence of CCL17 in human spleen tissue Immunohistochemistry of CCL17 in human spleen tissue with CCL17 antibody at 20 μg/ml. with CCL17 antibody at 5 μg/ml.
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
Rabbit polyclonal CCL17 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CCL17. IMMUNOGEN:
The immunogen is located within the last 50 amino acids of CCL17.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
CCL17 antibody can be used for detection of CCL17 by Western blot at 1 - 2 μg/mL.
APPLICATIONS: Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
October 1, 2021 1 https://www.prosci-inc.com/ccl17-antibody-7239.html POSITIVE CONTROL: 1) Cat. No. 1466 - Rat Spleen Tissue Lysate
2) Cat. No. 10-901 - Human Spleen Tissue Slide
PREDICTED MOLECULAR 10 kDa WEIGHT:
Properties
PURIFICATION: CCL17 Antibody is affinity chromatography purified via peptide column.
CLONALITY: Polyclonal
ISOTYPE: IgG
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
BUFFER: CCL17 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION: 1 mg/mL
CCL17 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one STORAGE CONDITIONS: year.
Additional Info
OFFICIAL SYMBOL: CCL17
CCL17 Antibody: TARC, ABCD-2, SCYA17, A-152E5.3, TARC, C-C motif chemokine 17, CC ALTERNATE NAMES: chemokine TARC
ACCESSION NO.: NP_002978
PROTEIN GI NO.: 4506829
GENE ID: 6361
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
CCL17 Antibody: CCL17, also known as TARC, binds to chemokine receptors CCR4 and CCR8 and plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. CCL17 is secreted from monocyte-derived DCs and BACKGROUND: endothelial cells and is responsible for selective recruitment and migration of activated Th2 lymphocytes. CCL17 is also required for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells under inflammatory conditions.
1) Imai T, Baba M, Nishimura M, et al. The T cell-directed CC chemokine TARC is a highly REFERENCES: specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997; 272:15036-42.
October 1, 2021 2 https://www.prosci-inc.com/ccl17-antibody-7239.html 2) Bernardini G, Hedrick J, Sozzani S, et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur. J. Immunol. 1998; 28:582-8.
3) Alferink J, Lieberam I, Reindl W, et al. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 2003; 197:585-99.
4) Stutte S, Quast T, Gerbitzki N, et al. Requirement of CCL17 for CCR7 and CXCR4- dependent migration of cutaneous dendritic cells. Proc. Natl. Acad. Sci. USA 2010; 107:8736-41.
ANTIBODIES FOR RESEARCH USE ONLY.
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October 1, 2021 3 https://www.prosci-inc.com/ccl17-antibody-7239.html