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Rabbit Anti-KAT7/FITC Conjugated antibody

SL17078R-FITC

Product Name: Anti-KAT7/FITC Chinese Name: FITC标记的组蛋白乙酰转移酶KAT7抗体 Hbo 1; HBO1; HBOa; Histone acetyltransferase binding to hORC1; Histone acetyltransferase binding to ORC1; Histone acetyltransferase KAT7; Histone acetyltransferase MYST2; K() acetyltransferase 7; KAT 7; Lysine Alias: acetyltransferase 7; MOZ; MOZ YBF2/SAS3 SAS2 and TIP60 protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST 2; MYST histone acetyltransferase 2; MYST protein 2; MYST-2; MYST2; MYST2_HUMAN; SAS 2; SAS2 and TIP60 protein 2; TIP60 protein 2; YBF2/SAS3; ZC2HC7. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 71kDa Form: Lyophilized or Liquid Concentration: 1mg/mlwww.sunlongbiotech.com immunogen: KLH conjugated synthetic peptide derived from human KAT7 Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: In the cell, transcription is regulated in part by the histone modification of chromatin. Product Detail: Specifically, histone acetyltransferase proteins and their associated complexes function with co-activators to regulate transcription. One family of histone acetyltransferases is the MYST family of transcriptional silencers, which is linked to ORC (origin recognition complex) function. The ORC is an initiator protein for DNA replication and mediates the acetylation of chromatin to control both DNA replication and expression. HBO1 (histone acetyltransferase binding to ORC) is a MYST family protein that interacts with ORC1, the largest subunit of the human ORC complex. HBO1 is a nuclear protein that is highly expressed in human testis. In addition to binding ORC, HBO1 represses AR ()-mediated transcription by binding AR through its N-terminal transcriptional repression domain. HBO1 may play a role in regulating AR-dependent gene transcription in normal and prostate cancer cells.

Function: Component of the HBO1 complex which has a -specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR- mediated transcription.

Subcellular Location: Nucleus; nucleoplasm.

Tissue Specificity: Ubiquitously expressed, with highest levels in testis.

Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity: Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger.

Database links: Entrezwww.sunlongbiotech.com Gene: 11143 Human Entrez Gene: 217127 Mouse

Entrez Gene: 303470 Rat

Omim: 609880 Human

SwissProt: O95251 Human

SwissProt: Q5SVQ0 Mouse

SwissProt: Q810T5 Rat

Unigene: 21907 Human Unigene: 90213 Mouse

Unigene: 12618 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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