Discrete Stochastic Processes, Chapter 2: Poisson Processes
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Effect of Probability Distribution of the Response Variable in Optimal Experimental Design with Applications in Medicine †
mathematics Article Effect of Probability Distribution of the Response Variable in Optimal Experimental Design with Applications in Medicine † Sergio Pozuelo-Campos *,‡ , Víctor Casero-Alonso ‡ and Mariano Amo-Salas ‡ Department of Mathematics, University of Castilla-La Mancha, 13071 Ciudad Real, Spain; [email protected] (V.C.-A.); [email protected] (M.A.-S.) * Correspondence: [email protected] † This paper is an extended version of a published conference paper as a part of the proceedings of the 35th International Workshop on Statistical Modeling (IWSM), Bilbao, Spain, 19–24 July 2020. ‡ These authors contributed equally to this work. Abstract: In optimal experimental design theory it is usually assumed that the response variable follows a normal distribution with constant variance. However, some works assume other probability distributions based on additional information or practitioner’s prior experience. The main goal of this paper is to study the effect, in terms of efficiency, when misspecification in the probability distribution of the response variable occurs. The elemental information matrix, which includes information on the probability distribution of the response variable, provides a generalized Fisher information matrix. This study is performed from a practical perspective, comparing a normal distribution with the Poisson or gamma distribution. First, analytical results are obtained, including results for the linear quadratic model, and these are applied to some real illustrative examples. The nonlinear 4-parameter Hill model is next considered to study the influence of misspecification in a Citation: Pozuelo-Campos, S.; dose-response model. This analysis shows the behavior of the efficiency of the designs obtained in Casero-Alonso, V.; Amo-Salas, M. -
Structures in the Mind: Chap18
© 2015 Massachusetts Institute of Technology All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means (including photocopying, recording, or informa- tion storage and retrieval) without permission in writing from the publisher. MIT Press books may be purchased at special quantity discounts for business or sales promotional use. For information, please email [email protected]. edu. This book was set in Times by Toppan Best-set Premedia Limited. Printed and bound in the United States of America. Library of Congress Cataloging-in-Publication Data Structures in the mind : essays on language, music, and cognition in honor of Ray Jackendoff / edited by Ida Toivonen, Piroska Csúri, and Emile van der Zee. pages cm Includes bibliographical references and index. ISBN 978-0-262-02942-1 (hardcover : alk. paper) 1. Psycholinguistics. 2. Cognitive science. 3. Neurolinguistics. 4. Cognition. I. Jackendoff, Ray, 1945- honoree. II. Toivonen, Ida. III. Csúri, Piroska. IV. Zee, Emile van der. P37.S846 2015 401 ′ .9–dc23 2015009287 10 9 8 7 6 5 4 3 2 1 18 The Friar’s Fringe of Consciousness Daniel Dennett Ray Jackendoff’s Consciousness and the Computational Mind (1987) was decades ahead of its time, even for his friends. Nick Humphrey, Marcel Kinsbourne, and I formed with Ray a group of four disparate thinkers about consciousness back around 1986, and, usually meeting at Ray’s house, we did our best to understand each other and help each other clarify the various difficult ideas we were trying to pin down. Ray’s book was one of our first topics, and while it definitely advanced our thinking on various lines, I now have to admit that we didn’t see the importance of much that was expressed therein. -
The VLTI's Astronomical Multi-Beam Combiner
Telescopes and Instrumentation DOI: 10.18727/0722-6691/5106 The Life and Times of AMBER: The VLTI’s Astronomical Multi-BEam combineR Willem-Jan de Wit1 instruments are scientifically inaugurated called the closure phase. The absolute Markus Wittkowski1 via their “first fringes”, which is the inter- phase of incoming light waves is scram- Frederik Rantakyrö 2 ferometric equivalent of “first light”. By bled by atmospheric turbulence, resulting Markus Schöller 1 the early 2000s, the integration of ESO’s in distortion over a pupil and global Antoine Mérand 1 interferometer into the VLT architecture phase shifts between the apertures in the Romain G. Petrov 3 was on track. array (called the piston). The degree and Gerd Weigelt 4 frequency of the scrambling increases Fabien Malbet 5 The first Paranal interference fringes were towards shorter wavelengths. As a result, Fabrizio Massi 6 produced by the VLT INterferometer the coherence time of the incoming Stefan Kraus7 Commissioning Instrument (VINCI) and wave ranges from a few milliseconds to Keiichi Ohnaka 8 MID-infrared Interferometric instrument (at best) some tens of milliseconds in the Florentin Millour 3 (MIDI), instruments that combined the optical regime. There is no way to beat Stéphane Lagarde 3 light from two telescopes. VINCI’s pur- the turbulence and recover the phase Xavier Haubois1 pose was to commission the interferome- without additional aids. When combining Pierre Bourget 1 ter’s infrastructure. MIDI, on the other three telescopes arranged in a closed Isabelle Percheron1 hand, was the first scientific instrument in triangle one can retrieve a new observa- Jean-Philippe Berger 5 operation using the VLTI in conjunction ble by adding the phases. -
Lecture.7 Poisson Distributions - Properties, Normal Distributions- Properties
Lecture.7 Poisson Distributions - properties, Normal Distributions- properties Theoretical Distributions Theoretical distributions are 1. Binomial distribution Discrete distribution 2. Poisson distribution 3. Normal distribution Continuous distribution Discrete Probability distribution Bernoulli distribution A random variable x takes two values 0 and 1, with probabilities q and p ie., p(x=1) = p and p(x=0)=q, q-1-p is called a Bernoulli variate and is said to be Bernoulli distribution where p and q are probability of success and failure. It was given by Swiss mathematician James Bernoulli (1654-1705) Example • Tossing a coin(head or tail) • Germination of seed(germinate or not) Binomial distribution Binomial distribution was discovered by James Bernoulli (1654-1705). Let a random experiment be performed repeatedly and the occurrence of an event in a trial be called as success and its non-occurrence is failure. Consider a set of n independent trails (n being finite), in which the probability p of success in any trail is constant for each trial. Then q=1-p is the probability of failure in any trail. 1 The probability of x success and consequently n-x failures in n independent trails. But x successes in n trails can occur in ncx ways. Probability for each of these ways is pxqn-x. P(sss…ff…fsf…f)=p(s)p(s)….p(f)p(f)…. = p,p…q,q… = (p,p…p)(q,q…q) (x times) (n-x times) Hence the probability of x success in n trials is given by x n-x ncx p q Definition A random variable x is said to follow binomial distribution if it assumes non- negative values and its probability mass function is given by P(X=x) =p(x) = x n-x ncx p q , x=0,1,2…n q=1-p 0, otherwise The two independent constants n and p in the distribution are known as the parameters of the distribution. -
Partnership As Experimentation: Business Organization and Survival in Egypt, 1910–1949
Yale University EliScholar – A Digital Platform for Scholarly Publishing at Yale Discussion Papers Economic Growth Center 5-1-2017 Partnership as Experimentation: Business Organization and Survival in Egypt, 1910–1949 Cihan Artunç Timothy Guinnane Follow this and additional works at: https://elischolar.library.yale.edu/egcenter-discussion-paper-series Recommended Citation Artunç, Cihan and Guinnane, Timothy, "Partnership as Experimentation: Business Organization and Survival in Egypt, 1910–1949" (2017). Discussion Papers. 1065. https://elischolar.library.yale.edu/egcenter-discussion-paper-series/1065 This Discussion Paper is brought to you for free and open access by the Economic Growth Center at EliScholar – A Digital Platform for Scholarly Publishing at Yale. It has been accepted for inclusion in Discussion Papers by an authorized administrator of EliScholar – A Digital Platform for Scholarly Publishing at Yale. For more information, please contact [email protected]. ECONOMIC GROWTH CENTER YALE UNIVERSITY P.O. Box 208269 New Haven, CT 06520-8269 http://www.econ.yale.edu/~egcenter Economic Growth Center Discussion Paper No. 1057 Partnership as Experimentation: Business Organization and Survival in Egypt, 1910–1949 Cihan Artunç University of Arizona Timothy W. Guinnane Yale University Notes: Center discussion papers are preliminary materials circulated to stimulate discussion and critical comments. This paper can be downloaded without charge from the Social Science Research Network Electronic Paper Collection: https://ssrn.com/abstract=2973315 Partnership as Experimentation: Business Organization and Survival in Egypt, 1910–1949 Cihan Artunç⇤ Timothy W. Guinnane† This Draft: May 2017 Abstract The relationship between legal forms of firm organization and economic develop- ment remains poorly understood. Recent research disputes the view that the joint-stock corporation played a crucial role in historical economic development, but retains the view that the costless firm dissolution implicit in non-corporate forms is detrimental to investment. -
The Dream Narrative As a Mode of Female Discourse in Epic Poetry
Transactions of the American Philological Association 140 (2010) 195–238 Incohat Ismene: The Dream Narrative as a Mode of Female Discourse in Epic Poetry* emma scioli University of Kansas summary: This article examines Ismene’s nightmare in book 8 of Statius’s Thebaid by contextualizing it within the epic’s narrative, comparing it with the dream narrations of other female characters in epic poetry, and aligning it with other typically female modes of subjective expression in epic, such as weaving, teichoscopy, and lamentation. My analysis shows that by exposing the diffi- culties inherent in retelling a dream, Statius demonstrates sympathy with the female perspective on the horrific war that constitutes the central action of his poem and foreshadows the subsequent inadequacy of words in reaction to such horror. i. introduction: ismene begins ismene, daughter of oedipus, is a character who has virtually no presence in the narrative of Statius’s Thebaid either before or after the small section devoted to the retelling of her dream and its aftermath (8.607–54); for this reason, the intricacy and allusiveness of this passage are all the more striking. In this scene, Ismene recounts to her sister Antigone a dream she has had, in which her wedding to her fiancé Atys is violently interrupted by a fire. After questioning the dream’s origin, Ismene discounts its meaning as incongruous with her understanding of her own waking reality and resumes * Shorter versions of this paper were delivered at the University of Rome, Tor Vergata, in 2004 and the 2005 APA meeting in Boston. I would like to thank audience members at both venues for useful feedback. -
A Model of Gene Expression Based on Random Dynamical Systems Reveals Modularity Properties of Gene Regulatory Networks†
A Model of Gene Expression Based on Random Dynamical Systems Reveals Modularity Properties of Gene Regulatory Networks† Fernando Antoneli1,4,*, Renata C. Ferreira3, Marcelo R. S. Briones2,4 1 Departmento de Informática em Saúde, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brasil 2 Departmento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brasil 3 College of Medicine, Pennsylvania State University (Hershey), PA, USA 4 Laboratório de Genômica Evolutiva e Biocomplexidade, EPM, UNIFESP, Ed. Pesquisas II, Rua Pedro de Toledo 669, CEP 04039-032, São Paulo, Brasil Abstract. Here we propose a new approach to modeling gene expression based on the theory of random dynamical systems (RDS) that provides a general coupling prescription between the nodes of any given regulatory network given the dynamics of each node is modeled by a RDS. The main virtues of this approach are the following: (i) it provides a natural way to obtain arbitrarily large networks by coupling together simple basic pieces, thus revealing the modularity of regulatory networks; (ii) the assumptions about the stochastic processes used in the modeling are fairly general, in the sense that the only requirement is stationarity; (iii) there is a well developed mathematical theory, which is a blend of smooth dynamical systems theory, ergodic theory and stochastic analysis that allows one to extract relevant dynamical and statistical information without solving -
POISSON PROCESSES 1.1. the Rutherford-Chadwick-Ellis
POISSON PROCESSES 1. THE LAW OF SMALL NUMBERS 1.1. The Rutherford-Chadwick-Ellis Experiment. About 90 years ago Ernest Rutherford and his collaborators at the Cavendish Laboratory in Cambridge conducted a series of pathbreaking experiments on radioactive decay. In one of these, a radioactive substance was observed in N = 2608 time intervals of 7.5 seconds each, and the number of decay particles reaching a counter during each period was recorded. The table below shows the number Nk of these time periods in which exactly k decays were observed for k = 0,1,2,...,9. Also shown is N pk where k pk = (3.87) exp 3.87 =k! {− g The parameter value 3.87 was chosen because it is the mean number of decays/period for Rutherford’s data. k Nk N pk k Nk N pk 0 57 54.4 6 273 253.8 1 203 210.5 7 139 140.3 2 383 407.4 8 45 67.9 3 525 525.5 9 27 29.2 4 532 508.4 10 16 17.1 5 408 393.5 ≥ This is typical of what happens in many situations where counts of occurences of some sort are recorded: the Poisson distribution often provides an accurate – sometimes remarkably ac- curate – fit. Why? 1.2. Poisson Approximation to the Binomial Distribution. The ubiquity of the Poisson distri- bution in nature stems in large part from its connection to the Binomial and Hypergeometric distributions. The Binomial-(N ,p) distribution is the distribution of the number of successes in N independent Bernoulli trials, each with success probability p. -
1 One Parameter Exponential Families
1 One parameter exponential families The world of exponential families bridges the gap between the Gaussian family and general dis- tributions. Many properties of Gaussians carry through to exponential families in a fairly precise sense. • In the Gaussian world, there exact small sample distributional results (i.e. t, F , χ2). • In the exponential family world, there are approximate distributional results (i.e. deviance tests). • In the general setting, we can only appeal to asymptotics. A one-parameter exponential family, F is a one-parameter family of distributions of the form Pη(dx) = exp (η · t(x) − Λ(η)) P0(dx) for some probability measure P0. The parameter η is called the natural or canonical parameter and the function Λ is called the cumulant generating function, and is simply the normalization needed to make dPη fη(x) = (x) = exp (η · t(x) − Λ(η)) dP0 a proper probability density. The random variable t(X) is the sufficient statistic of the exponential family. Note that P0 does not have to be a distribution on R, but these are of course the simplest examples. 1.0.1 A first example: Gaussian with linear sufficient statistic Consider the standard normal distribution Z e−z2=2 P0(A) = p dz A 2π and let t(x) = x. Then, the exponential family is eη·x−x2=2 Pη(dx) / p 2π and we see that Λ(η) = η2=2: eta= np.linspace(-2,2,101) CGF= eta**2/2. plt.plot(eta, CGF) A= plt.gca() A.set_xlabel(r'$\eta$', size=20) A.set_ylabel(r'$\Lambda(\eta)$', size=20) f= plt.gcf() 1 Thus, the exponential family in this setting is the collection F = fN(η; 1) : η 2 Rg : d 1.0.2 Normal with quadratic sufficient statistic on R d As a second example, take P0 = N(0;Id×d), i.e. -
ONE SAMPLE TESTS the Following Data Represent the Change
1 WORKED EXAMPLES 6 INTRODUCTION TO STATISTICAL METHODS EXAMPLE 1: ONE SAMPLE TESTS The following data represent the change (in ml) in the amount of Carbon monoxide transfer (an indicator of improved lung function) in smokers with chickenpox over a one week period: 33, 2, 24, 17, 4, 1, -6 Is there evidence of significant improvement in lung function (a) if the data are normally distributed with σ = 10, (b) if the data are normally distributed with σ unknown? Use a significance level of α = 0.05. SOLUTION: (a) Here we have a sample of size 7 with sample mean x = 10.71. We want to test H0 : μ = 0.0, H1 : μ = 0.0, 6 under the assumption that the data follow a Normal distribution with σ = 10.0 known. Then, we have, in the Z-test, 10.71 0.0 z = − = 2.83, 10.0/√7 which lies in the critical region, as the critical values for this test are 1.96, for significance ± level α = 0.05. Therefore we have evidence to reject H0. The p-value is given by p = 2Φ( 2.83) = 0.004 < α. − (b) The sample variance is s2 = 14.192. In the T-test, we have test statistic t given by x 0.0 10.71 0.0 t = − = − = 2.00. s/√n 14.19/√7 The upper critical value CR is obtained by solving FSt(n 1)(CR) = 0.975, − where FSt(n 1) is the cdf of a Student-t distribution with n 1 degrees of freedom; here n = 7, so − − we can use statistical tables or a computer to find that CR = 2.447, and note that, as Student-t distributions are symmetric the lower critical value is CR. -
Poisson Versus Negative Binomial Regression
Handling Count Data The Negative Binomial Distribution Other Applications and Analysis in R References Poisson versus Negative Binomial Regression Randall Reese Utah State University [email protected] February 29, 2016 Randall Reese Poisson and Neg. Binom Handling Count Data The Negative Binomial Distribution Other Applications and Analysis in R References Overview 1 Handling Count Data ADEM Overdispersion 2 The Negative Binomial Distribution Foundations of Negative Binomial Distribution Basic Properties of the Negative Binomial Distribution Fitting the Negative Binomial Model 3 Other Applications and Analysis in R 4 References Randall Reese Poisson and Neg. Binom Handling Count Data The Negative Binomial Distribution ADEM Other Applications and Analysis in R Overdispersion References Count Data Randall Reese Poisson and Neg. Binom Handling Count Data The Negative Binomial Distribution ADEM Other Applications and Analysis in R Overdispersion References Count Data Data whose values come from Z≥0, the non-negative integers. Classic example is deaths in the Prussian army per year by horse kick (Bortkiewicz) Example 2 of Notes 5. (Number of successful \attempts"). Randall Reese Poisson and Neg. Binom Handling Count Data The Negative Binomial Distribution ADEM Other Applications and Analysis in R Overdispersion References Poisson Distribution Support is the non-negative integers. (Count data). Described by a single parameter λ > 0. When Y ∼ Poisson(λ), then E(Y ) = Var(Y ) = λ Randall Reese Poisson and Neg. Binom Handling Count Data The Negative Binomial Distribution ADEM Other Applications and Analysis in R Overdispersion References Acute Disseminated Encephalomyelitis Acute Disseminated Encephalomyelitis (ADEM) is a neurological, immune disorder in which widespread inflammation of the brain and spinal cord damages tissue known as white matter. -
6.1 Definition: the Density Function of Th
CHAPTER 6: Some Continuous Probability Distributions Continuous Uniform Distribution: 6.1 Definition: The density function of the continuous random variable X on the interval [A; B] is 1 A x B B A ≤ ≤ f(x; A; B) = 8 − < 0 otherwise: : Application: Some continuous random variables in the physical, management, and biological sciences have approximately uniform probability distributions. For example, suppose we are counting events that have a Poisson distribution, such as telephone calls coming into a switchboard. If it is known that exactly one such event has occurred in a given interval, say (0; t),then the actual time of occurrence is distributed uniformly over this interval. Example: Arrivals of customers at a certain checkout counter follow a Poisson distribution. It is known that, during a given 30-minute period, one customer arrived at the counter. Find the probability that the customer arrived during the last 5 minutes of the 30-minute period. Solution: As just mentioned, the actual time of arrival follows a uniform distribution over the interval of (0; 30). If X denotes the arrival time, then 30 1 30 25 1 P (25 X 30) = dx = − = ≤ ≤ Z25 30 30 6 Theorem 6.1: The mean and variance of the uniform distribution are 2 B 2 2 B 1 x B A A+B µ = A x B A = 2(B A) = 2(B− A) = 2 : R − h − iA − It is easy to show that (B A)2 σ2 = − 12 Normal Distribution: 6.2 Definition: The density function of the normal random variable X, with mean µ and variance σ2, is 2 1 (1=2)[(x µ)/σ] n(x; µ, σ) = e− − < x < ; p2πσ − 1 1 where π = 3:14159 : : : and e = 2:71828 : : : Example: The SAT aptitude examinations in English and Mathematics were originally designed so that scores would be approximately normal with µ = 500 and σ = 100.