(10) Patent No.: US 7790905 B2
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US007790905B2 (12) United States Patent (10) Patent No.: US 7,790,905 B2 Tawa et al. (45) Date of Patent: Sep. 7, 2010 (54) PHARMACEUTICAL PROPYLENE GLYCOL 5,177.262 A 1/1993 Taylor et al. SOLVATE COMPOSITIONS 5,242.942 A 9, 1993 Costanzo et al. (75) Inventors: Mark Tawa, Brighton, MA (US); Orn 30 lso t s Almarsson, Shrewsbury, MA (US); 5.324,351 A 6/1994 OShlack et all Julius Remenar, Framingham, MA (US) - 4 5,332,834 A 7, 1994 Bhattacharya et al. (73) Assignee: McNeil-PPC, Inc., Skillman, NJ (US) 5,338,644 A 8/1994 Taylor et al. 5,354,556 A 10/1994 Sparks et al. (*) Notice: Subject to any disclaimer, the term of this 5,356.467 A 10, 1994 O'Shlack et al. patent is extended or adjusted under 35 5,366,738 A 11/1994 Rork et al. U.S.C. 154(b) by 1554 days. 5,380,867 A 1/1995 Bhattacharya et al. (21) Appl. No.: 10/747,742 5,384.327 A 1/1995 Costanzo et al. 5,412,094. A 5/1995 Amos et al. (22) Filed: Dec. 29, 2003 5,414,997 A 5, 1995 Tailer 5,466,823. A 1 1/1995 Talley et al. 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