Anti-XPO4 / Exportin 4 Antibody (ARG59469)

Product datasheet [email protected]

ARG59469 Package: 50 μg anti-XPO4 / Exportin 4 antibody Store at: -20°C

Summary

Product Description Rabbit Polyclonal antibody recognizes XPO4 / Exportin 4

Tested Reactivity Hu

Tested Application WB

Host Rabbit

Clonality Polyclonal

Isotype IgG

Target Name XPO4 / Exportin 4

Antigen Species Human

Immunogen Partial recombinant protein corresponding to aa. 775-1000 of Human XPO4 / Exportin 4.

Conjugation Un-conjugated

Alternate Names Exportin-4; Exp4; exp4

Application Instructions

Application table Application Dilution

WB 1 - 3 µg/ml

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Calculated Mw 130 kDa

Properties

Form Liquid

Buffer PBS, 0.05% Sodium azide and 0.05% BSA.

Preservative 0.05% Sodium azide

Stabilizer 0.05% BSA

Concentration 0.5 - 1 mg/ml

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation www.arigobio.com 1/2 Gene Symbol XPO4

Gene Full Name exportin 4

Background XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

Function Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran- GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [UniProt]

Cellular Localization Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. [UniProt]

Images

ARG59469 anti-XPO4 / Exportin 4 antibody WB image

Western blot: Heart lysate stained with ARG59469 anti-XPO4 / Exportin 4 antibody at 1 µg/ml dilution.