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To Download the Bicentennial Symposium Program Biomedicine in the New Century The Yale School of Medicine Bicentennial Symposium April 28–29, 2011 Mary S. Harkness Auditorium Yale School of Medicine, New Haven, CT program.indd 1 4/20/11 12:48 PM thursday, april 28 8:25 am Dean Robert J. Alpern, MD Introductory Remarks 8:30 am Eric R. Kandel, MD On the Persistence of Memory Storage Introduced by James E. Rothman, PhD 9:20 am Huda Y. Zoghbi, MD Rett Syndrome: From Genomes to Epigenomes and Neuropsychiatric Conditions Introduced by Pietro De Camilli, MD break 10:30 am Elizabeth H. Blackburn, PhD Maintaining Chromosome Ends: From Basic Science to Human Health and Disease Introduced by Joann B. Sweasy, PhD 11:20 am Sir Michael Marmot, PhD Fair Society, Healthy Lives Introduced by Paul D. Cleary, PhD break 1:30 pm Phillip A. Sharp, PhD Roles of RNA in Gene Regulation Introduced by Joan A. Steitz, PhD 2:20 pm Harold E. Varmus, MD Provocative Questions About Cancer Introduced by Joseph Schlessinger, PhD break 3:30 pm Elaine Fuchs, PhD Skin Stem Cells: Their Biology & Clinical Promise Introduced by Haifan Lin, PhD 4:20 pm David Baltimore, PhD MicroRNAs in Inflammation and Cancer Introduced by Richard A. Flavell, PhD program.indd 2 4/20/11 12:48 PM friday, april 29 8:25 am Carolyn W. Slayman, PhD Introductory Remarks 8:30 am Joseph L. Goldstein, MD Surviving Starvation: Essential Role of the Ghrelin–Growth Hormone Axis (Part I) Introduced by Robert J. Alpern, MD 9:20 am Michael S. Brown, MD Surviving Starvation: Essential Role of the Ghrelin–Growth Hormone Axis (Part II) Introduced by Robert J. Alpern, MD break 10:30 am Robert J. Lefkowitz, MD Seven–Transmembrane Receptors Introduced by Michael Simons, MD 11:20 am Susan L. Lindquist, PhD Tackling Protein Misfolding Diseases Introduced by Stephen M. Strittmatter, MD, PhD break 2:00 pm Charles L. Sawyers, MD Overcoming Drug Resistance to Cancer Therapies Introduced by Thomas J. Lynch, Jr., MD 2:50 pm Peter S. Kim, PhD Toward Development of an HIV Vaccine Introduced by Richard P. Lifton, MD, PhD 3:40 pm Robert M. Califf, MD Translational Medicine: Moving from Better Ideas to Better Health Introduced by Harlan M. Krumholz, MD, SM 4:30 pm Dean Robert J. Alpern, MD Closing Remarks program.indd 3 4/20/11 12:48 PM program.indd 4 4/20/11 12:48 PM Celebrating 200 Years of History at Yale School of Medicine Transformation has been a hallmark of Yale School of Medicine since its founding following passage of an Act of Incorporation by the Connecticut Legislature in October 1810. During this watershed academic year of 2010–2011, the School of Medicine is honoring its past, present, and future in myriad ways, and I welcome you to our Bicentennial Symposium, the premier event in our yearlong celebration. As Yale School of Medicine prepared to celebrate its centennial 100 years ago, the school faced an uncertain future, as was the case with many American medical schools at the time. But Abraham Flexner’s landmark 1910 report on medical education marked a turning point—Flexner deemed the School of Medicine one of only two in New England worthy of continued investment, and Yale energetically advanced on all fronts in the years afterward. In the past, the school has been home to luminaries such as John P. Peters, MD, Dorothy M. Horstmann, MD, Louis S. Goodman, MD, Alfred Gilman, PhD, C.-E.A. Winslow, Dr. PH, Aaron Lerner, MD, PhD, Paul B. Beeson, MD, and George Palade, MD, among many others, and today our faculty is equally distinguished. It is with great pleasure that I welcome some of the world’s leading thinkers and practitioners in medicine and biomedical science to this forum. We are deeply honored to benefit from their wisdom. I hope that the knowledge you take away from this event enables you to advance your own understanding of, and appreciation for, the interesting times in which we live, learn, and practice our art. Robert J. Alpern, MD program.indd 5 4/20/11 12:48 PM program.indd 6 4/20/11 12:48 PM thursday, april 28 8:30 am Eric R. Kandel, MD On the Persistence of Memory Storage Eric R. Kandel, MD, is University Professor at Columbia, Fred Kavli Professor and Director, Kavli Institute for Brain Science and a Senior Investigator with the Howard Hughes Medical Institute. A graduate of Harvard College and N.Y.U. School of Medicine, Kandel trained in Neurobiology at the NIH and in Psychiatry at Harvard Medical School. He joined the faculty of the College of Physicians and Surgeons at Columbia University in 1974 as the founding director of the Center for Neurobiology and Behavior. At Columbia Kandel organized the neuroscience curriculum. He is an editor of Principles of Neural Science, the standard textbook in the field. He recently has written a book on the brain for the general public titled In Search of Memory: The Emergence of a New Science of Mind, which won both the L.A. Times and U.S. National Academy of Science Awards for best book in Science and Technology in 2008. A documentary film based on that book also titled In Search of Memory is now showing in the United States. Eric Kandel’s research has been concerned with the molecular mechanisms of memory storage in Aplysia and mice. More recently, he has studied animal models in mice of memory disorders and mental illness. Kandel has received eighteen honorary degrees, is a member of the U.S. National Academy of Sciences as well as the National Science Academies of Austria, Germany and France. He has been recognized with the Albert Lasker Award, the Heineken Award of the Netherlands, the Gairdner Award of Canada, the Harvey Prize and the Wolf Prize of Israel, the National Medal of Science USA and the Nobel Prize for Physiology or Medicine in 2000, which he shared with Paul Greengard and Arvid Carlsson. program.indd 7 4/20/11 12:48 PM program.indd 8 4/20/11 12:48 PM thursday, april 28 9:20 am Huda Y. Zoghbi, MD Rett Syndrome: From Genomes to Epigenomes and Neuropsychiatric Conditions Huda Zoghbi, MD, is Professor of Pediatrics, Neurology, Neuroscience, and Molecular and Human Genetics at Baylor College of Medicine and serves as an Investigator with the Howard Hughes Medical Institute. She is also the Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. Zoghbi’s interest is in using the tools of modern genetics to understand the proper development of the brain as well as what goes awry in specific neurodevelopmental and neurodegenerative conditions. She has published seminal work regarding the molecular basis of Rett syndrome and of late-onset neurodegenerative diseases. Dr. Zoghbi is a member of several professional organizations including the NIH Scientific Management Review Board, the Mcknight Foundation Neuroscience Board, and the Lasker Jury. Among Dr. Zoghbi’s honors are the E. Mead Johnson Award from Society of Pediatric Research, the IPSEN prize in neuronal plasticity, the Bristol Myers-Squibb Neuroscience Distinguished Achievement Award, and the Vilcek Prize. In 2000 she was elected to the Institute of Medicine, and in 2004 she was elected to the National Academy of Sciences. program.indd 9 4/20/11 12:48 PM program.indd 10 4/20/11 12:48 PM thursday, april 28 10:30 am photo by susan merrell susan by photo Elizabeth H. Blackburn, PhD Maintaining Chromosome Ends: From Basic Science to Human Health and Disease Elizabeth H. Blackburn, PhD, Morris Herztein Professor of Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the area of telomere and telomerase research. She discovered the molecular nature of telomeres—the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information—and the ribonucleoprotein enzyme, telomerase. Blackburn and her research team at the University of California, San Francisco, are working with various cells including human cells, with the goal of understanding telomerase and telomere biology. Blackburn earned her BSc (1970) and MSc (1972) degrees from the University of Melbourne in Australia, and her PhD (1975) from the University of Cambridge in England. She did her postdoctoral work in Molecular and Cellular Biology from 1975 to 1977 at Yale. In 1978, Blackburn joined the faculty at the University of California at Berkeley in the Department of Molecular Biology. In 1990, she joined the Department of Microbiology and Immunology at UC San Francisco, where she served as Department Chair from 1993 to 1999. Blackburn is currently a faculty member in the Department of Biochemistry and Biophysics at UCSF. She is also a Non-Resident Fellow of the Salk Institute. Throughout her career, Blackburn has been honored by her peers as the recipient of many prestigious awards. She was elected President of the American Society for Cell Biology for the year 1998. Blackburn is an elected Fellow of the American Academy of Arts and Sciences (1991), the Royal Society of London (1992), the American Academy of Microbiology (1993), and the American Association for the Advancement of Science (2000). She was elected Foreign Associate of the National Academy of Sciences in 1993, and was elected as a Member of the Institute of Medicine in 2000. She was awarded the Albert Lasker Medical Research Award in Basic Medical Research (2006). In 2007 she was named one of TIME Magazine’s 100 Most influential People and she is the 2008 North American Laureate for L’Oreal-UNESCO For Women in Science.
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