S y m p t o m s , D i a g n o s i s , T r e a t m e n t Pediatric Acute-onset Neuropsychiatric Syndrome Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections Alliance to Solve PANS & Immune-Related Encephalopathies www.ASPIRE.care
[email protected] 1. Abrupt, acute onset of 1. Presence of OCD and/or tics, Obsessive-compulsive disorder and/or particularly multiple, complex or Severe restricted food intake unusual tics 2. Concurrent presence of additional 2. Age Requirement (Symptoms of the behavioral or neurological symptoms disorder first become evident with similarly acute onset and severity between 3 years of age and puberty) from at least 2 of the 7 following categories: Acute onset and episodic (relapsing- 3. remitting) course 1.Anxiety, separation anxiety 2.Emotional lability or depression 3.Irritability, aggression, and/or 4. Association with Group A Streptococcal oppositional behaviors (GAS) infection 4.Behavioral or developmental regression 5.Deterioration in school performance (loss 5. Association with Neurological of math skills, handwriting changes, Abnormalities ADHD-like behaviors, executive functioning, etc.) Note: Comorbid neuropsychiatric symptoms are 6.Sensory or motor abnormalities, tics universally present in PANDAS, similar to the 7.Somatic signs: sleep disturbances, diagnostic criteria for PANS with similarly abrupt enuresis, or urinary frequency onset/exacerbation as the primary symptoms of Symptoms are not better explained by a PANDAS. In particular, the somatic symptoms 3. such as urinary frequency, mydriasis, and known neurologic or medical disorder insomnia, help differentiate PANDAS from 4. Age requirement – None Tourette syndrome or non-PANDAS OCD.