Howard Jacobs Iodine Deficiency Legends & Facts LIFE BEYOND the UK’S SECRET a SEARCH for the HORMONES EPIDEMIC IRISH GIANT P20 P10 P24

Total Page:16

File Type:pdf, Size:1020Kb

Howard Jacobs Iodine Deficiency Legends & Facts LIFE BEYOND the UK’S SECRET a SEARCH for the HORMONES EPIDEMIC IRISH GIANT P20 P10 P24 ISSUE 108 SUMMER 2013 ISSN 0965-1128 (PRINT) ISSN 2045-6808 (ONLINE) THE NEWSLETTER OF THE SOCIETY FOR ENDOCRINOLOGY GP Commissioning FIND YOUR ESSENTIAL GUIDE INSIDE P6-9 Howard Jacobs Iodine Deficiency Legends & Facts LIFE BEYOND THE UK’S SECRET A SEARCH FOR THE HORMONES EPIDEMIC IRISH GIANT P20 P10 P24 CAREER DEVELOPMENT SOCIETY BES 2013 NEW! CASE REPORT WORKSHOPS The latest news from PUBLICATION Two-track learning for Young the leading event Open access, online resource Endocrinologists for endocrinology, diabetes P3 P13 and metabolism P16 www.endocrinology.org/endocrinologist WELCOME Find us on Facebook & Twitter... Editor: Dr Miles Levy Associate Editor: Dr Tony Coll Editorial Board: Dr Karen Featherstone, Dr Paul Foster, Dr Paul Grant, A WORD FROM Dr Olympia Koulouri Managing Editor: Dr Jennie Evans THE EDITOR... Sub-editor: Caroline Brewser Design: Third Floor Design Society for Endocrinology 22 Apex Court, Woodlands, Bradley Stoke, Bristol BS32 4JT, UK Tel: 01454 642200 Email: [email protected] Web: www.endocrinology.org So, this is the second issue since I took over the reins as Editor, and I hope you can see Company Limited by Guarantee some green shoots of progress. We’ve actually had to keep some articles to one side this Registered in England No. 349408 time, due to the high level of contributions, which is great. It is only a matter of time before Registered Office as above Registered Charity No. 266813 publication in The Endocrinologist trumps a first author Nature paper! ©2013 Society for Endocrinology The views expressed by contributors It will be summer when you read this, but I am currently in a post-Society BES are not necessarily those of the Society. dust-settling situation. I always find it exceptionally hard to know where to put my The Society, editorial board and authors cannot accept liability for any errors conference paraphernalia (although I am finding my new pile of empty hessian Society or omissions. for Endocrinology bags easier on the eye than the old blue ones). In truth, this Society OFFICERS BES was one of the best yet, and the usual moans from scientists about the number of Prof AB Grossman (President) clinical sessions (and vice versa) were strangely absent. Our new Editorial Board will keep Prof DW Ray (General Secretary) Prof GR Williams (Treasurer) us abreast of key scientific developments, and we will be providing an in-depth critical Prof CJ McCabe (Programme Secretary) analysis of important endocrine papers, including high impact non-Society journals as COUNCIL MEMBERS well as our own publications. Dr SG Ball, Prof K Chapman, Dr H Christian, Prof A Logan, The thorny subject of commissioning of endocrine services is covered in this issue. Most GPs Prof JR Seckl, Prof RM Sharpe, tend to think that endocrinology is a dark art not to be meddled with, so we are probably Prof AP Weetman, Prof A White safe. Nevertheless we need to make sure our patients get the opinions they deserve – ours! COMMITTEE CHAIRS Clinical: Prof JA Franklyn Finance: Prof GR Williams The feature articles highlight the links between our subject and popular art and culture, Nominations: Prof J Buckingham underpinned by a raw fascination with the science of endocrinology. This combination Nurse: Mrs V Kieffer of knowledge and enthusiasm for our specialty will outlive whatever transient political Programme: Prof CJ McCabe Public Engagement: Prof S Whitehead thoughts of the day preside, reinforcing that we as endocrinologists are here to stay. Publications: Prof DW Ray Science: Prof K Chapman As always, we are very grateful to all who have contributed this time round. We look forward YE Steering Group: Dr V Cabrera-Sharp to your help in continuing to raise the calibre of this magazine to stratospheric levels. THE ENDOCRINOLOGIST ENQUIRIES Please contact Jennie Evans [email protected] BEST WISHES ADVERTISING MILES LEVY Please contact [email protected] CONTENTS HEADLINES ON THE COVER... CORPORATE SUPPORTERS Career Development Workshops 3 18 The Society’s generous benefactors New publications P6 Dates & deadlines GP COMMISSIONING FEATURES Don’t let April’s new regime HOT TOPICS 20 Howard Jacobs: The interview confuse your CCGs and PCTs: 4 The latest endocrine research 24 Searching for the Irish giant read the latest opinions SOCIETY news Screening for the AIP gene 11 Voice of the Future 26 Sitting comfortably? Seeking a clear steer Emma Wilmot thinks not... SECRET EPIDEMIC... 12 Logo inspiration AND FINALLY... 13 Society BES: Clinical Prize Lecture 27 P10 Meeting news Images in endocrinology IODINE DEFICIENCY 16 New home for case reports Time to take action Streamlined CPD Biodynamics conference You can view this issue online: 17 Nurses’ news: ENETS update www.endocrinology.org/endocrinologist Become a contributor... Contact the Editorial office at [email protected] The Society welcomes news items, contributions, article suggestions and letters to the editor. We would also like to hear your feedback on this issue of the newsletter. Deadline for news items for the Autumn 2013 issue: 17 July 2013. Deadline for news items for the Winter 2013 issue: 16 September 2013. 2 | THE endocrinologist | SUMMER 2013 facebook.com/SocietyforEndocrinology twitter.com/Soc_Endo HEADLINES CAREER Clinical Update 2013 SOCIETY Development Clinical Update 2013 takes place CALENDAR Workshops on 4–6 November in Bristol. It provides essential training for Steventon, trainees and new consultants 16–17 September 2013 OXfordshire in endocrinology and diabetes, ENDOCRINE NURSE 18–20 October with a programme covering UPDATE the national curriculum in Stratford upon Avon This new event is aimed at those endocrinology and diabetes 18–20 October 2013 registered for a PhD/MD or early issued by the Joint Royal Colleges CAREER DEVELOPMENT career postdoctoral researchers of Physicians Training Board. WORKSHOPS with an interest in pursuing The 3-day residential course Steventon, Oxfordshire clinical academic or basic scientific comprises lectures and interactive research in endocrinology. workshops, to allow delegates 4–6 November 2013 The Career Development to discuss best clinical practice CLINICAL UPDATE Workshops will run along two in day-to-day scenarios. This Bristol distinct tracks (suitable for both year will see John Newell-Price Wiebke Arlt and basic scientists and clinician take over from Wiebke Arlt as John Newell-Price December 2013 scientists): Programme Co-ordinator. REGIONAL CLINICAL CASES MEETING • Career planning More information and online registration are available at Belfast (aimed at mid- to late PhD www.endocrinology.org/meetings/clinicalupdate delegates and early postdocs) 24–27 March 2014 • Fellowship and grant SOCIETY FOR application (aimed primarily ENDOCRINOLOGY at postdoc delegates) Happy first birthday! BES 2014 Liverpool Activities include: Endocrine Connections, the Society’s • Critical appraisal of new open access journal, is 1 year see a journal article old this summer. The first year has been a great success, thanks to www.endocrinology.org/ • Learning presentation skills meetings for full details • How to write a grant ongoing support from Society for application Endocrinology Members and the wider endocrinology community. • Talks by representatives Submissions flow in steadily, with from grant-awarding bodies high quality papers published from Grant Eight faculty members will be across the breadth of the field. AND on hand to facilitate discussions, Remember, we are still offering PRIZE offer advice, and share experience. DEADLINES Registration is free to members half price fees for the first 200 of the Society (subject to a £100 papers accepted. Find out more returnable deposit). and view the latest content at www.endocrineconnections.com. 15 July For more information see UNDERGRADUATE www.endocrinology.org/meetings/ ACHIEVEMENT AWARD CDW 15 August CONFERENCE GRANT CONGRATULATIONS NEW 27 November EARLY CAREER GRANT We congratulate John Lazarus, PRESIDENT-Elect who has been appointed the FOR ENDOCRINE 15 December Regional Co-ordinator West SOCIETY CONFERENCE GRANT and Central Europe for the International Council for Control Richard Santen MD from the University of see of Iodine Deficiency Disorders. Virginia has been elected as President-Elect of www.endocrinology.org/ You can read more about his work The US Endocrine Society. Richard will start his grants for full details of on page 10. term of office on 18 June 2013. all Society grants ENDOCRINOLOGY, DIABETES & METABOLISM CASE REPORTS This exciting new open access, online resource endorsed by the Society for Endocrinology will publish and link together case reports in endocrinology, diabetes and metabolism, facilitating discovery, connections and comparisons. Society Members will receive exclusive publication discounts. Turn to page 16 for more details. THE endocrinologist | SUMMER 2013 | 3 ENDOCRINE-RELATED CANCER ENDOCRINE-RELATED FEBRUARY 2013 VOLUME 20 HT NUMBER 1 ISSN 1351-0088 (PRINT) PAGES E5–E7, P9–P12, F1–F188, C29–C31, R99–R161, 457–613, L11–L36, X1 L11–L36, 457–613, R99–R161, C29–C31, F1–F188, P9–P12, E5–E7, PAGES ISSN 1479-6821 (ONLINE) HOT TOPICS Volume 2 ISSN: 2049-3614 JANUARYVOLUME 2013 216 NUMBER 1 ISSN 0022-0795 (PRINT) ISSN 1479-6805 (ONLINE) SOCIETY FOR Endocrinology JOURNAL OF ENDOCRINOLOGY JOURNAL OF MOLECULAR ENDOCRINOLOGY MOLECULAR OF JOURNAL VOL 1 20 NUMBER NUMBER ENDOCRINE- OFFICIAL JOURNALS RELATED CANCER HORMONES AND CANCER: Society members have free access to the current FROM RESEARCH TO THERAPIES PAGES E5–E7, P9–P12, F1–F188, C29–C31, R99–R161, 457–613, L11–L36, X1 PAGES E5–E7, P9–P12, F1–F188, C29–C31, R99–R161, 457–613, L11–L36, X1 L11–L36, 457–613, R99–R161, C29–C31, F1–F188, P9–P12, E5–E7, PAGES content of Journal of Endocrinology, Journal of FEBRUARY 2013 VOLUME 50 NUMBER 1 ISSN 0952-5041 (PRINT) Molecular Endocrinology, Endocrine-Related Cancer ISSN 1479-6813 (ONLINE) and Clinical Endocrinology via VOL.216 NO. JOURNAL OF www.bioscialliance.org. VOL 50 50 NO. ENDOCRINOLOGY 1 PHYSIOLOGY, METABOLISM JOURNAL OF AND TRANSLATION 1 MOLECULAR Endocrine Connections is an open access journal and THEMATIC REVIEWS ON ADIPOKINES published by bio ENDOCRINOLOGY as such is free to all.
Recommended publications
  • The Recent History of Tumour Necrosis Factor (Tnf)
    THE RECENT HISTORY OF TUMOUR NECROSIS FACTOR (TNF) The transcript of a Witness Seminar held by the History of Modern Biomedicine Research Group, Queen Mary University of London, on 14 July 2015 Edited by A Zarros, E M Jones, and E M Tansey Volume 60 2016 ©The Trustee of the Wellcome Trust, London, 2016 First published by Queen Mary University of London, 2016 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 1 91019 5208 All volumes are freely available online at www.histmodbiomed.org Please cite as: Zarros A, Jones E M, Tansey E M. (eds) (2016) The Recent History of Tumour Necrosis Factor (TNF). Wellcome Witnesses to Contemporary Medicine, vol. 60. London: Queen Mary University of London. CONTENTS What is a Witness Seminar? v Acknowledgements E M Tansey and A Zarros vii Illustrations and credits ix Abbreviations xi Introduction Professor Jon Cohen xv Transcript Edited by A Zarros, E M Jones, and E M Tansey 1 Appendix 1 Timeline of important events in the history of TNF 73 Appendix 2 Simplified overview of the main biological actions of TNF in rheumatoid arthritis 75 Appendix 3 Overview of TNF inhibitors mentioned in the current Witness Seminar transcript 77 Glossary 79 Biographical notes 83 References 93 Index 105 Witness Seminars: Meetings and publications 111 WHAT IS A WITNESS SEMINAR? The Witness Seminar is a specialized form of oral history, where several individuals associated with a particular set of circumstances or events are invited to meet together to discuss, debate, and agree or disagree about their memories.
    [Show full text]
  • Deborah Doniach, a Pioneer in the Field of Autoimmunity
    RESEARCH HIGHLIGHTS WOMEN IN IMMUNOLOGY primary biliary cirrhosis and clarified how autoantibodies to gastric parietal cells play a role in pernicious anaemia. Deborah Doniach, a pioneer Deborah’s research team were also among the first to show that auto- antibodies specific for pancreatic in the field of autoimmunity islet cell antigens were present in the Deborah Doniach (1912–2004) As a clinician, Deborah recog- sera of patients with type 1 diabetes was a clinician and immunologist nized the need for a clinical diagno- mellitus. Although the formal proof who made the ground-breaking stic service to monitor patient the ground- that type 1 diabetes mellitus was an observation of the autoimmune autoantibodies and pushed for the breaking autoimmune disease was to come basis of Hashimoto disease, which establishment of a clinical immuno- later, these early studies provided damages the thyroid gland. This logy service in the Depart ment observation an indication that there might be an paved the way for the subsequent of Immunology at the Middlesex of the auto- autoimmune aetiology. identification of other organ-specific Hospital. As well as forming a immune basis Deborah had a wonderfully autoimmune diseases. blueprint for the diagnostic and of Hashimoto inquisitive mind that embraced Deborah was born in Geneva, monitoring facilities now routinely new ideas and technologies. studied medicine at the Sorbonne available, this service also greatly disease … This stood her in good stead in Paris and completed her medical assisted the development of many paved the way throughout her academic career. degree at the Royal Free Hospital clinical research programmes. for the sub- Deborah was a remarkable woman Medical School in London.
    [Show full text]
  • Microsomal Antibodies
    80 BRITISH MEDICAL JOURNAL 13 APRIL 1974 about 25 %. These calculations suggest that the failure rate affect the reported failure rate. In -the present series only might be about 2% higher with dose 4 than with dose 1. The women who developed a positive I.A.G.T. result were observed difference (about 1-5%) was in reasonable agreement. counted as failures. The five women with anti-D detectable There was evidence of an association between transplacental only with enzyme-,treated cells at the end of their second haemorrhages of 4 ml or more and failures with dose 4. pregnancy were not counted as failures. Nevertheless, even Twelve women had -an estimated transplacental haemorrhage if they had been included the overall failure rate would have of 4 ml or more after a first pregnancy, and t,here were three risen by less than 1%. additional women with a transplacental haemorrhage of this In the United Kingdom and in a few other countries a extent who were excluded from the trial. If it is assumed dose of 100 ,ug anti-D has for some time been used for that these three women would, if they had been included, routine administration to unimmunized D-negative women have distributed themselves at random among the dose groups recently delivered of a D-positive infant. Our results support then there would have been only about one additional woman the contention that this dose has a success rate which is not wit,h a ,transplacental haemorrhage of 4 ml or more treated appreciably different from that observed with a dose of 200- with dose 4.
    [Show full text]
  • Wellcome Witnesses to Twentieth Century Medicine
    WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _______________________________________________________________ TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES ______________________________________________ SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY ______________________ ENDOGENOUS OPIATES _____________________________________ THE COMMITTEE ON SAFETY OF DRUGS __________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY P P CATTERALL D A CHRISTIE S V WILLHOFT L A REYNOLDS Volume One – April 1997 CONTENTS WHAT IS A WITNESS SEMINAR? i E M TANSEY TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES EDITORS: E M TANSEY AND P P CATTERALL TRANSCRIPT 1 INDEX 33 SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY EDITORS: E M TANSEY, S V WILLHOFT AND D A CHRISTIE TRANSCRIPT 35 INDEX 65 ENDOGENOUS OPIATES EDITORS: E M TANSEY AND D A CHRISTIE TRANSCRIPT 67 INDEX 100 THE COMMITTEE ON SAFETY OF DRUGS EDITORS: E M TANSEY AND L A REYNOLDS TRANSCRIPT 103 INDEX 133 WHAT IS A WITNESS SEMINAR? Advances in medical science and medical practice throughout the twentieth century, and especially after the Second World War, have proceeded at such a pace, and with such an intensity, that they provide new and genuine challenges to historians. Scientists and clinicians themselves frequently bemoan the rate at which published material proliferates in their disciplines, and the near impossibility of ‘keeping up with the literature’. Pity, then, the poor historian, trying to make sense of this mass of published data, scouring archives for unpublished accounts and illuminating details, and attempting throughout to comprehend, contextualize, reconstruct and convey to others the stories of the recent past and their significance. The extensive published record of modern medicine and medical science raises particular problems for historians: it is often presented in a piecemeal but formal fashion, sometimes seemingly designed to conceal rather than reveal the processes by which scientific medicine is conducted.
    [Show full text]
  • Materials and Methods Qua~Itali
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central MITOCHONDRIAL ANTIBODIES IN PRIMARY BILIARY CIRRHOSIS I. LOCALIZATION OF THE ANTIGEN TO MITOCHONDRIAL MEMBRANES Bx PETER A. BERG, M.D., DEBORAH DONIACH, M.D., AX'D IVAN M. ROITT, D.Pm~. (From th¢ Rheumatology Research Department, Middlesex Hospital Medical School, London, England) P~rEs 26 Am) 27 (Received for publication 31 March 1967) A number of reports have described complement fixation reactions of sera from patients with primary biliary cirrhosis (PBC) using subcellular tissue fractions (1-3). Subsequently it was shown that almost all these patients give cytoplasmic staining in the immunofluorescent test, reactingpreferentially with cells rich in mitochondria (4-6). These antibodies are consistently absent in extrahepatic biliary obstruction and their detection has proved of clinical im- portance in that surgical exploration can be avoided in cases of jaundice due to primary biliary cirrhosis. Further studies are now reported demonstrating that these antibodies are directed specifically against mitochondrial membranes. Materials and Methods Patients.--34 sera were selected from known cases of primary biliary cirrhosis on the basis of the characteristic fluorescent pattern, a high titer in the complement fixation test with rat liver homogenate, and absence of unwanted serological reactions including antinuclear and rheumatoid factors, smooth muscle fluorescence, or organ-specific thyroid and gastric anti- bodies. Qua~italive Complvm~ Fixation Me~hod (CFT).--The method of Rapport and Graf (7) was used as applied to the study of microsomal antigens (8, 9). The Ca/Mg CFT buffer tablets (Oxoid Ltd., London) were made up with addition of 0.1% bovine serum albumin.
    [Show full text]
  • Selida Poster Obituary
    Obituary for Professor Ian Reay Mackay (1922-2020): A pioneer Autoimmunologist Mediterr J Rheumatol 2020;31(1):98-9 R N A U L O J O F N R A H E E U N M A A R T R O E L T I O E-ISSN: 2529-198X D G E Y MEDITERRANEAN JOURNALM OF RHEUMATOLOGY March 2020 | Volume 31 | Issue 1 MEDITERRANEAN JOURNAL 31 1 OF RHEUMATOLOGY 2020 This work is licensed under a Creative Commons Attribution 4.0 International License. OBITUARY Obituary for Professor Ian Reay Mackay (1922-2020): A pioneer Autoimmunologist Mediterr J Rheumatol 2020;31(1):98-9 https://doi.org/10.31138/mjr.31.1.98 It is with great sadness that I learnt of the death of Medicine, and is best known for developing the theory Professor Ian Reay Mackay, AM, FAA, FRACP, FRCP, of clonal selection. Burnet’s theory influenced the way FRCPA on 24th March 2020 at the age of 98. Professor research on immunology was performed, and was sub- Mackay was an Australian clinician and researcher and stantiated when Peter Medawar succeeded in performing a true pioneer in the field of autoimmunity. His research transplants of tissue between different mouse foetuses. led to a new era of autoimmune diseases, regarding their The results of their work influences organ transplanta- diagnosis and pathogenesis, as well as treatment with tion management even until now. At that time, several immunosuppressive drugs. chronic diseases were of unknown aetiology. Burnet and Professor Mackay was educated at the University of Mackay went a step further to propose several of those Melbourne, later training at Hammersmith Hospital, in to be of autoimmune nature.
    [Show full text]
  • The Thyroid Cytotoxic Autoantibody
    THE THYROID CYTOTOXIC AUTOANTIBODY I. J. Forbes, … , Deborah Doniach, I. L. Solomon J Clin Invest. 1962;41(5):996-1006. https://doi.org/10.1172/JCI104579. Research Article Find the latest version: https://jci.me/104579/pdf Journal of Clinical Investigation Vol. 41, No. 5, 1962 THE THYROID CYTOTOXIC AUTOANTIBODY By I. J. FORBES,* I. M. ROITT, DEBORAH DONIACH AND I. L. SOLOMON t (From the Middlesex Hospital Medical School, London, England) (Submitted for publication November 27, 1961; accepted January 18, 1962) The presence of circulating autoantibodies in micromethod of Donnelley (6), and was known to sup- patients with Hashimoto's disease suggests that port good cell growth. Fresh normal serum was always used in tests with serum fractions or absorbed sera. autoimmunity is implicated in the disease process, Guinea pig serum could be used as a source of comple- but the ultimate proof of an autoimmune patho- ment but was occasionally cytotoxic. The cultures were genesis of thyroiditis and other human diseases incubated for 18 to 24 hours at 370C. must be obtained by demonstrating the autoag- The sensitivity of each gland was established by in- gressive action of antibodies or immunologically cluding as controls known weakly cytotoxic sera and competent cells on the living tissue in its normal potent Hashimoto sera, sometimes set up in dilutions. With sensitive glands, all the cells were killed by a environment. strong standard serum; the weaker sera usually allowed The demonstration by Pulvertaft, Doniach, Roitt a few clumps of cells to be established. Where cells and Hudson (1, 2) of a serum factor capable of survived in final dilutions of less than 1: 120 of the destroying human thyroid cells in tissue culture standard strong serum, the gland was too insensitive to is an advance in this direction.
    [Show full text]
  • Roitt's Essential Immunology
    Roitt’s Essential Immunology This title is also available as an e‐book. For more details, please see www.wiley.com/buy/9781118415771 or scan this QR code: Thirteenth edition Roitt’s Essential Immunology Peter J. Delves PhD Division of Infection and Immunity UCL London, UK Seamus J. Martin PhD, FTCD, MRIA The Smurfit Institute of Genetics Trinity College Dublin, Ireland Dennis R. Burton PhD Department of Immunology and Microbial Science The Scripps Research Institute La Jolla, California, USA Ivan M. Roitt MA, DSc (Oxon), FRCPath, Hon FRCP (Lond), FRS Centre for Investigative and Diagnostic Oncology Middlesex University London, UK This edition first published 2017 © 2017 by John Wiley and Sons, Ltd. © 1971, 1974, 1977, 1980, 1984, 1988, 1991, 1994, 1997, 2001, 2006, 2011 by Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt Registered Office John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial Offices 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley‐blackwell The right of the author to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.
    [Show full text]
  • Dame Sheila Sherlock Moved to the Village in 1929 and Attended the Folkestone County School for Girls
    Doctor’s plaque is unveiled A NEW plaque to commemorate the life of a world-renowned physician has been unveiled in Sandgate. Dame Sheila Sherlock moved to the village in 1929 and attended the Folkestone County School for Girls. When she attended Edinburgh University in 1936 she faced great resistance to the idea of a woman working in medicine. But she went on to excel in her chosen field of disease of the liver, writing more than 600 medical and scientific journals over her career. She died in 2001, aged 83. A blue plaque in her honour ‘i was unveiled by Sandgate we —S i . Society at 99 Sandgate High al - Street, close to her former home, COMMEMORATE: Sandgate Society unveiled a plaque to Dame Sheila Sherlock Devonshire Terrace. HY THE HERAAD 2H geete> A/uly She popularised needle biopsies, making an exact diagnosis possible. In 1966 she helped to create what is now a standard test in diagnosing primary cirrhosis of the liver. Sheila Patricia Violet Sherlock was born on March 31 1918. From Folkestone Grammar School she was rejected by several medical schools, who had few places for women, and went to Edinburgh University, graduating top in Medicine in 1941. Prevented from holding a house job At Former Devonshire because she was female, she Terrace became clinical assistant to James Learmonth, Professor of Surgery. 1918 — 2001 After a Rockefeller Fellowship at Yale University and a further year at the Hammersmith, she was 9. Dame Sheila Sherlock who appointed Lecturer and Honorary died aged 83, was the world's Consultant Physician.
    [Show full text]
  • Roitt's Essential Immunology
    Roitt’s Essential Immunology Peter J. Delves Professor Delves obtained his PhD from the University of London in 1986 and is a Professor of Immunology at UCL (University College London). His research has focused on molecular aspects of antigen recognition. He has authored and edited a number of immunology books, and teaches the subject at a broad range of levels. Seamus J. Martin Professor Martin received his PhD from Th e National University of Ireland in 1990 and trained as a post - doctoral fellow at University College London (with Ivan Roitt) and Th e La Jolla Institute for Allergy and Immunology, California, USA (with Doug Green). Since 1999, he is the holder of the Smurfi t Chair of Medical Genetics at Trinity College Dublin and is also a Science Foundation Ireland Principal Investigator. His research is focused on various aspects of programmed cell death (apoptosis) in the immune system and in cancer and he has received several awards for his work in this area. He has previously edited two books on apoptosis and was elected as a Member of Th e Royal Irish Academy in 2006 and as a member of Th e European Molecular Biology Organisation (EMBO) in 2009. Dennis R. Burton Professor Burton obtained his BA in Chemistry from the University of Oxford in 1974 and his PhD in Physical Biochemistry from the University of Lund in Sweden in 1978. After a period at the University of Sheffi eld, he moved to the Scripps Research Institute in La Jolla, California in 1989 where he is Professor of Immunology and Molecular Biology.
    [Show full text]
  • Is Mitochondrial Antibody Diagnostic of Primary Biliary Cirrhosis?
    Gut: first published as 10.1136/gut.22.2.136 on 1 February 1981. Downloaded from Guit, 1981, 22, 136-140 Is mitochondrial antibody diagnostic of primary biliary cirrhosis? LINDA E MUNOZ, H C THOMAS,* P J SCHEUER, DEBORAH DONIACH, AND SHEILA SHERLOCK From the Department of Medicine and Histopathology, Royal Free Hospital, London, and the Department ofImmunology, Middlesex Hospital Medical School, London SUMMARY In a series of 218 patients diagnosed as having primary bilary cirrhosis only nine ex- hibited a negative serum mitochondrial antibody. On examining additional specimens from these. patients, seven were found to be positive, giving a final incidence of greater than 99%. The two. patients whose sera remained negative for the mitochondrial antibody had liver histology com- patible with the diagnosis of primary biliary cirrhosis, but a firm diagnosis could not be reached. Three additional mitochondrial antibody positive subjects who were asymptomatic and exhibited. normal serum alkaline phosphatase were shown on liver biopsy to have stage I primary biliary- cirrhosis. The presence of a positive serum mitochondrial antibody in a patient with or without abnormalities in liver function tests strongly suggests the diagnosis of primary biliary cirrhosis. Primary biliary cirrhosis is a disease of unknown Free Hospital identified 218 patients with the diag- aetiology in which the epithelium of the intrahepatic nosis of primary biliary cirrhosis. In nine patients. biliary tree is destroyed by a chronic inflammatory mitochondrial antibody was negative at presenta- process characterised by the presence of granu- tion, the diagnosis being made on the basis of http://gut.bmj.com/ lomata. symptoms, biochemistry, and liver histology.
    [Show full text]
  • The Royal College of Physicians and Oxford Brookes University Medical Sciences Video Archive MSVA 020
    © Oxford Brookes University The Royal College of Physicians and Oxford Brookes University Medical Sciences Video Archive MSVA 020 Dame Sheila Sherlock in interview with Sir Gordon Wolstenholme Oxford, 19 March 1987 GW Sheila, I think it would have to be a pretty obtuse member of our profession in our country if you were to go to him and say the word liver, if he didn’t immediately associate it with the name Sherlock. And you have achieved, not only in this country but of course in many countries abroad, a really tremendous reputation, and you have honorary fellowships and memberships, degrees and so on in many countries. I am interested in the origins of all this, and you started by some strange chance in the same town I think as William Harvey. Whether that had anything to do with it, I doubt, but it’s an interesting coincidence. SS I was at school at the Folkestone County School for Girls, which was obviously in Folkestone where William Harvey was born, and a school for which I am very grateful. It’s now lost its sixth form, alas, but it was an excellent school set in beautiful grounds, which gave facilities for everything. So it was a good school. GW It must have been good. You went from there to Edinburgh? SS I went from there to Edinburgh. GW And I mean, you had already prepared to go into a medical school. SS Yes. GW And the school was good enough? SS Ah not really. For instance it didn’t provide zoology, it only provided botany.
    [Show full text]