Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes
Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Mariotti, Marco, Perry G. Ridge, Yan Zhang, Alexei V. Lobanov, Thomas H. Pringle, Roderic Guigo, Dolph L. Hatfield, and Vadim N. Gladyshev. 2012. Composition and evolution of the vertebrate and mammalian selenoproteomes. PLoS ONE 7(3): e33066. Published Version doi:10.1371/journal.pone.0033066 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:10341925 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes Marco Mariotti1,2., Perry G. Ridge3., Yan Zhang1,4., Alexei V. Lobanov1, Thomas H. Pringle5, Roderic Guigo2, Dolph L. Hatfield6, Vadim N. Gladyshev1* 1 Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 2 Center for Genomic Regulation and Universitat Pompeu Fabra, Barcelona, Spain, 3 Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska, United States of America, 4 Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, 5 Sperling Foundation, Eugene, Oregon, United States of America, 6 Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Abstract Background: Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec).
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