Anti-PRMT1 monoclonal antibody, clone 5F0-I0-I23 (DCABH-2481) This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
Product Overview Mouse monoclonal to PRMT1
Antigen Description Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
Specificity This antibody detects endogenous levels of PRMT1 and does not cross react with related proteins.
Immunogen Purified recombinant fragments from the N terminus of Human PRMT1 protein expressed in E.coli (NM_001536.2).
Isotype IgG2b
Source/Host Mouse
Species Reactivity Mouse, Rat, Rabbit, Dog, Human
Clone 5F0-I0-I23
Purity Protein A purified
Conjugate Unconjugated
Applications WB, ELISA
Positive Control HeLa and A549 cell lysates.
Format Liquid
Size 100 μg
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Buffer pH: 7.40; Preservative: 0.2% Sodium azide; Constituents: 49% Tris glycine, 50% Glycerol, 0.88% Sodium chloride
Preservative 0.2% Sodium Azide
Storage store at -20°C. Avoid repeated freeze / thaw cycles.
Ship Shipped at 4°C.
GENE INFORMATION
Gene Name PRMT1 protein arginine methyltransferase 1 [ Homo sapiens ]
Official Symbol PRMT1
Synonyms PRMT1; protein arginine methyltransferase 1; HMT1 (hnRNP methyltransferase, S. cerevisiae) like 2 , HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) , HRMT1L2; protein arginine N- methyltransferase 1; ANM1; HCP1; interferon receptor 1-bound protein 4;
Entrez Gene ID 3276
Protein Refseq NP_001193971
UniProt ID A0A087X1W2
Chromosome Location 19q13
Pathway Androgen Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem; mRNA processing, organism-specific biosystem;
Function N-methyltransferase activity; N-methyltransferase activity; histone methyltransferase activity; histone methyltransferase activity (H4-R3 specific); methyltransferase activity; protein binding; transferase activity;
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved