Anti-PRMT1 monoclonal , clone 5F0-I0-I23 (DCABH-2481) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to PRMT1

Antigen Description Arginine that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.

Specificity This antibody detects endogenous levels of PRMT1 and does not cross react with related proteins.

Immunogen Purified recombinant fragments from the N terminus of Human PRMT1 expressed in E.coli (NM_001536.2).

Isotype IgG2b

Source/Host Mouse

Species Reactivity Mouse, Rat, Rabbit, Dog, Human

Clone 5F0-I0-I23

Purity Protein A purified

Conjugate Unconjugated

Applications WB, ELISA

Positive Control HeLa and A549 cell lysates.

Format Liquid

Size 100 μg

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Buffer pH: 7.40; Preservative: 0.2% Sodium azide; Constituents: 49% Tris glycine, 50% Glycerol, 0.88% Sodium chloride

Preservative 0.2% Sodium Azide

Storage store at -20°C. Avoid repeated freeze / thaw cycles.

Ship Shipped at 4°C.

GENE INFORMATION

Gene Name PRMT1 protein arginine methyltransferase 1 [ Homo sapiens ]

Official Symbol PRMT1

Synonyms PRMT1; protein arginine methyltransferase 1; HMT1 (hnRNP methyltransferase, S. cerevisiae) like 2 , HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) , HRMT1L2; protein arginine N- methyltransferase 1; ANM1; HCP1; interferon receptor 1-bound protein 4;

Entrez Gene ID 3276

Protein Refseq NP_001193971

UniProt ID A0A087X1W2

Chromosome Location 19q13

Pathway Androgen Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem; mRNA processing, organism-specific biosystem;

Function N-methyltransferase activity; N-methyltransferase activity; histone methyltransferase activity; histone methyltransferase activity (H4-R3 specific); methyltransferase activity; protein binding; transferase activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved