ECM−receptor interaction all sink node genes ● ● ● ●

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10 0

0 10 log −1 −2

mBL

non−mBL intermediate ECM−receptor interaction (genes with data)

COL1A1 ITGA1 FN1 VTN G10505 ITGB1 VTN FN1 COL1A1 LAMC3 ITGA8 CD44 TNC ITGB1 VWF FN1 SPP1 ITGAV COL1A1 ITGB3 LAMC3 TNC LAMC3 ITGA2 COL1A1 ITGB1 IBSP CHAD TNC FN1 COMP SDC1 SPP1 ITGA9 COMP COL1A1 ITGB1 LAMC3 VTN TNC LAMC3 FN1 RELN ITGA2B Focal adhesion LAMC3 SV2C... ITGA3 VWF ITGB3 COMP ITGB1 ITGA10 COMP COL1A1 COL1A1 ITGB1 FN1 COMP CD36

VTN GP5 FN1 ITGAV GP1BA ITGA4 ITGA11 IBSP VWF GP1BB ITGB1 COL1A1 ITGB5 SPP1 ITGB1 SPP1 GP9 COL1A1 GP6 FN1 ITGA5 ITGAV FN1 FN1 ITGB6 ITGB1 ITGAV TNC LAMC3 SPP1 ITGB1 VTN COL1A1 AGRN DAG1 DAG1 ITGA6 FN1 HSPG2 LAMC3 ITGAV ITGB1 LAMC3 ITGB8 VTN COMP CD47

ITGA7 FN1 ITGA4 ITGA6 LAMC3 ITGB1 ITGB7 LAMC3 ITGB4 G10505 HMMR ECM−receptor interaction (sink nodes)

COL1A1 ITGA1 FN1 VTN G10505 ITGB1 VTN FN1 COL1A1 LAMC3 ITGA8 CD44 TNC ITGB1 VWF FN1 SPP1 ITGAV COL1A1 ITGB3 LAMC3 TNC LAMC3 ITGA2 COL1A1 ITGB1 IBSP CHAD TNC FN1 COMP SDC1 SPP1 ITGA9 COMP COL1A1 ITGB1 LAMC3 VTN TNC LAMC3 FN1 RELN ITGA2B Focal adhesion LAMC3 SV2C... ITGA3 VWF ITGB3 COMP ITGB1 ITGA10 COMP COL1A1 COL1A1 ITGB1 FN1 COMP CD36

VTN GP5 FN1 ITGAV GP1BA ITGA4 ITGA11 IBSP VWF GP1BB ITGB1 COL1A1 ITGB5 SPP1 ITGB1 SPP1 GP9 COL1A1 GP6 FN1 ITGA5 ITGAV FN1 FN1 ITGB6 ITGB1 ITGAV TNC LAMC3 SPP1 ITGB1 VTN COL1A1 AGRN DAG1 DAG1 ITGA6 FN1 HSPG2 LAMC3 ITGAV ITGB1 LAMC3 ITGB8 VTN COMP CD47

ITGA7 FN1 ITGA4 ITGA6 LAMC3 ITGB1 ITGB7 LAMC3 ITGB4 G10505 HMMR ECM−receptor interaction mBL

COL1A1 ITGA1 FN1 VTN G10505 ITGB1 VTN FN1 COL1A1 LAMC3 ITGA8 CD44 TNC ITGB1 VWF FN1 SPP1 ITGAV COL1A1 ITGB3 LAMC3 TNC LAMC3 ITGA2 COL1A1 ITGB1 IBSP CHAD TNC FN1 COMP SDC1 SPP1 ITGA9 COMP COL1A1 ITGB1 LAMC3 VTN TNC LAMC3 FN1 RELN ITGA2B Focal adhesion LAMC3 SV2C... ITGA3 VWF ITGB3 COMP ITGB1 ITGA10 COMP COL1A1 COL1A1 ITGB1 FN1 COMP CD36

VTN GP5 FN1 ITGAV GP1BA ITGA4 ITGA11 IBSP VWF GP1BB ITGB1 COL1A1 ITGB5 SPP1 ITGB1 SPP1 GP9 COL1A1 GP6 FN1 ITGA5 ITGAV FN1 FN1 ITGB6 ITGB1 ITGAV TNC LAMC3 SPP1 ITGB1 VTN COL1A1 AGRN DAG1 DAG1 ITGA6 FN1 HSPG2 LAMC3 ITGAV ITGB1 LAMC3 ITGB8 VTN COMP CD47

ITGA7 FN1 ITGA4 ITGA6 LAMC3 ITGB1 ITGB7 LAMC3 ITGB4 G10505 HMMR ECM−receptor interaction intermediate

COL1A1 ITGA1 FN1 VTN G10505 ITGB1 VTN FN1 COL1A1 LAMC3 ITGA8 CD44 TNC ITGB1 VWF FN1 SPP1 ITGAV COL1A1 ITGB3 LAMC3 TNC LAMC3 ITGA2 COL1A1 ITGB1 IBSP CHAD TNC FN1 COMP SDC1 SPP1 ITGA9 COMP COL1A1 ITGB1 LAMC3 VTN TNC LAMC3 FN1 RELN ITGA2B Focal adhesion LAMC3 SV2C... ITGA3 VWF ITGB3 COMP ITGB1 ITGA10 COMP COL1A1 COL1A1 ITGB1 FN1 COMP CD36

VTN GP5 FN1 ITGAV GP1BA ITGA4 ITGA11 IBSP VWF GP1BB ITGB1 COL1A1 ITGB5 SPP1 ITGB1 SPP1 GP9 COL1A1 GP6 FN1 ITGA5 ITGAV FN1 FN1 ITGB6 ITGB1 ITGAV TNC LAMC3 SPP1 ITGB1 VTN COL1A1 AGRN DAG1 DAG1 ITGA6 FN1 HSPG2 LAMC3 ITGAV ITGB1 LAMC3 ITGB8 VTN COMP CD47

ITGA7 FN1 ITGA4 ITGA6 LAMC3 ITGB1 ITGB7 LAMC3 ITGB4 G10505 HMMR ECM−receptor interaction non−mBL

COL1A1 ITGA1 FN1 VTN G10505 ITGB1 VTN FN1 COL1A1 LAMC3 ITGA8 CD44 TNC ITGB1 VWF FN1 SPP1 ITGAV COL1A1 ITGB3 LAMC3 TNC LAMC3 ITGA2 COL1A1 ITGB1 IBSP CHAD TNC FN1 COMP SDC1 SPP1 ITGA9 COMP COL1A1 ITGB1 LAMC3 VTN TNC LAMC3 FN1 RELN ITGA2B Focal adhesion LAMC3 SV2C... ITGA3 VWF ITGB3 COMP ITGB1 ITGA10 COMP COL1A1 COL1A1 ITGB1 FN1 COMP CD36

VTN GP5 FN1 ITGAV GP1BA ITGA4 ITGA11 IBSP VWF GP1BB ITGB1 COL1A1 ITGB5 SPP1 ITGB1 SPP1 GP9 COL1A1 GP6 FN1 ITGA5 ITGAV FN1 FN1 ITGB6 ITGB1 ITGAV TNC LAMC3 SPP1 ITGB1 VTN COL1A1 AGRN DAG1 DAG1 ITGA6 FN1 HSPG2 LAMC3 ITGAV ITGB1 LAMC3 ITGB8 VTN COMP CD47

ITGA7 FN1 ITGA4 ITGA6 LAMC3 ITGB1 ITGB7 LAMC3 ITGB4 G10505 HMMR