University of Hawai‘i, Board of Regents, 2444 Dole Street, Bachman 209, Honolulu, HI 96822 Telephone No. (808) 956-8213; Fax No. (808) 956-5156 Notice of Meeting UNIVERSITY OF HAWAI‘I BOARD OF REGENTS COMMITTEE ON RESEARCH AND INNOVATION Members: Regent Eugene Bal (Chair), Regent Stanford Yuen (Vice Chair), and Regents Higa, Putnam, Shinsato, Tagorda, and Wilson
Date: Wednesday, November 1, 2017 Time: 12:30 p.m. Place: University of Hawaiʻi at Mānoa Information Technology Building 1st Floor Conference Room 105A/B 2520 Correa Road Honolulu, Hawai‘i 96822
AGENDA I. Call Meeting to Order II. Approval of Minutes of the September 7, 2017 Meeting
III. Public Comment Period for Agenda Items: All written testimony on agenda items received after posting of this agenda and up to 24 hours in advance of the meeting will be distributed to the board. Late testimony on agenda items will be distributed to the board within 24 hours of receipt. Written testimony may be submitted via US mail, email at bor@hawaii.edu, or facsimile at 956-5156. Individuals submitting written testimony are not automatically signed up for oral testimony. Registration for oral testimony on agenda items will be provided at the meeting location 15 minutes prior to the meeting and closed once the meeting begins. Oral testimony is limited to three (3) minutes. All written testimony submitted are public documents. Therefore, any testimony that is submitted verbally or in writing, electronically or in person, for use in the public meeting process is public information.
IV. Agenda Items A. For Information 1. FY18 Q1 Extramural Awards Report 2. Update on UH Cancer Center P30 Proposal and Status 3. Update on Act 38 (2017) and Act 39 (2017), and proposed commercialization structure 4. Life Cycle of Proposals and Awards
V. Adjournment
Accommodation required by law for Persons with Disabilities requires at least (5) five days prior notice to the board office at 956-8213 or [email protected]. Office of the Vice President for Research and Innovation UNIVERSITY of HAWAI’F UN!VEtHY SYSTEM ET 26 11 :42 ‘17 OCT24 P2 :26! October 25, 2017 UNIVERSITYOFHNIi PRESIDENT’SOFFICE MEMORANDUM
TO: Eugene Bal III,Chairperson BOR Committee on Research and Innovation
VIA: David Lassner
FROM: Vassilis L. Syrmo Vice President for esearch and Innova ion
SUBJECT: BOR COMMITTEE ON RESEARCH AND INNOVATION AGENDA MATERIALS FOR NOVEMBER 2017 MEETING
Please find attached the following materials that will be discussed at the November 1, 2017 BOR Committee on Research and Innovation meeting:
A. For Information:
1. FY18 Qi Extramural Awards Analysis (VPRI presentation) a. FY18 QJ Research and Innovation Metrics Summary b. FY18 Monthly Report of Extramural Awards (as of September 30, 2017) c. FY17 Q4 Extramural Awards Analysis Report
2. UH Cancer Center Annual Report to the BOR — Update on UH Cancer Center P30 Proposal & Status (UH Cancer Center Director presentation) 3. Update on Act 38 and Act 39; proposed commercialization structure (VPRI presentation)
4. Life Cycle of Proposals &Awards (VPRI presentation)
Attachments
2444 Dole Street, Bachman Hall Honolulu, Hawai’i 96822 Telephone: (808) 956-5006 • Fax: (808) 956-5286 An Equal Opportunity/Affirmative Action Institution FY18 Q1 Extramural Awards Analysis
BOR Research & Innovation Committee Meeting November 1, 2017 Overview
• FY18 Q1 Recap • Significant Awards by Campus • Award Amounts by Location • Q1 Analysis
2 FY18 Q1 Recap
• FY18 Q1 total is $164 million, 9.6% less than FY17 Q1 ($182 million)
• 2nd underperforming quarter in a row; might be a cause for concern
3 Quarterly Extramural Awards $ millions 2011 2012 2013 2014 2015 2016 2017 2018 Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
4 FY18 Q1 Significant Awards by Campus
Campus Sponsor Type Sponsor Project Title Amount Department of Homeland National Disaster Preparedness Mānoa Federal Security Training Center 5,000,000 Department of UH Hilo and HawCC Cooperative Hilo Federal Education Arrangement Development Grant 830,715 Department of UH West Oahu PIKO: Po o, Ike, Kino, West O‘ahu Federal Education and Ohana Project 2,000,000 Business and Kamehameha UH West Hawaii Kulike Success Hawai‘i CC Other Schools Through College Readiness 229,878 Ho'ala hou - Renewing a Pathway to Department of Student Success Through Culture- Honolulu CC Federal Education Based Learning 576,039 Strengthening Kapiolani’s Campus and Culture for Student Success: Kauhale Department of Ke Kuleana, the Responsibility of the Kapi‘olani CC Federal Education Whole Village 1,970,810 Department of Kaua‘i CC Federal Education Crossing Cultures 831,167 Department of Pa'a Ke Kahua: Strengthening Our Leeward CC Federal Education Foundation 1,998,368 Akeakamai I Ka La Hiki Ola: Scientific National Science Exploration Beneath The Life-Bringing Maui College Federal Foundation Sun (NSF ATST Mitigation Plan) 2,000,000 Hanaiaulu: Feed and Grow, Nurturing Student Parents and STEM at Department of Windward Community College through Windward CC Federal Education Renovation 1,989,018 Department of Managing Partner of Pacific Disaster UH System Federal Defense Center 3,621,979
5 FY18 Q1 Award Amounts by Location ($ millions)
2018-17 Campus 2015 2016 2017 2018 Change Mānoa 138 122 130 112 -13.2% Hilo 11 7 6 7 25.0% West O‘ahu 3 5 5 5 -5.2% Hawai‘i CC 2 0 0 0 870.8% Honolulu CC 0 2 2 1 -55.8% Kapi‘olani CC 3 3 5 4 21.4% Kaua‘i CC 1 1 2 1 -55.6% Leeward CC 3 3 4 3 -16.7% Maui College 6 7 4 10 149.5% Windward CC 4 4 6 6 -10.4% UH System 21 10 18 15 -17.3% TOTAL 191 166 182 164 -9.6%
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 3.8%
6 Major Changes by Location
• Maui College (+$5.8m) – Two new awards from National Science Foundation (NSF) totaling $1.7 million – Incremental funding for NSF award totaling $2 million (no increment in FY 17) – Supplemental funding for Hawai‘i Department of Human Services totaling $1.8 million (Received in Q2 as opposed to Q1 in FY 17 – timing)
7 Major Changes by Location (cont.)
• UH System (-$3.1m) – Office of the VP for Academic Planning & Policy: FY17 Q1 – $5 million Kamehameha Schools award; FY18 Q1 – No award of comparable size – Applied Research Laboratory: FY18 Q1 – Two new Department of Defense awards totaling $1.9 million
8 Major Changes by Location (cont.)
• UH Mānoa (-$17.1m) – Federal award decreases in • HHS - Department of Health and Human Services (-$12.8m) – Primarily affecting School of Medicine and UH Cancer Center • ED - Department of Education (-$2.8m) – Primarily affecting College of Education • NSF - National Science Foundation (-$2.9m) – Various units
9 Major Changes by Location (cont.)
• UH Mānoa – Non-federal award decreases • Hawai‘i – Health Organizations (-$11.6m) – Primarily affecting School of Medicine (usually receive majority of these awards in Q1 - timing)
10 FY Q1 Analysis
• Expected seasonal increase in FY18 Q1 federal awards did not occur – For example, UH Mānoa had declines in three of top five federal sponsors (HHS, ED and NSF)
• In some cases, possible that timing of incremental funding is affecting comparability on a quarter-by-quarter basis – Whether overall FY 18 results will improve remains to be seen
11 Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016 Program Type Count Amount Count Amount Research 383 $ 82,212,163 372 $ 84,332,181 Non-Research 299 $ 84,469,597 285 $ 97,312,322
Total 682 $166,681,760 657 $181,644,503
Note: The detailed award listing is available at: http://www.ors.hawaii.edu/index.php/bor-reports
The FY 2017 year-to-date total was: $181,805,711 The unofficial FY 2018 year-to-date total is: 682 awards totaling $164,493,372
1 Contracts and Grants Awards As of Quarter One – FY 2018
Cumulative Quarterly
2 Contracts and Grants Expenditures As of Quarter One – FY 2018
3 Contracts and Grants F&A Recovery As of Quarter One – FY 2018
4 OTT Research & Innovation Metrics FY 2018 – First Quarter Summary
FY 2018 FY 2017 Metric 7/1/17 – 9/30/17 7/1/16 – 9/30/16 Invention Disclosures 8 10 U.S. Provisional Patents Filed 6 6 U.S. Non-Provisional Patents Filed 8 5 U.S. Non-Provisional Patents Issued 0 1 License Agreements 3 2 Royalty Revenue $7,246.82 13,240.07
5 Invention Disclosures As of Quarter One – FY 2018
Inventions Disclosed 18 60 16 52 50 14 12 40 10 10 8 30 8 Quarterly 6 20 4 10 2 0 0 Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6 U.S. Provisional Patents Filed As of Quarter One – FY 2018
U.S. Provisional Patents Filed 14 40
12 35 35 30 10 25 8 6 6 20 6
Quarterly 15 4 10
2 5
0 0 Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7 U.S. Non-Provisional Patents Filed As of Quarter One – FY 2018
U.S. Non-Provisional Patents Filed 9 18 8 8 16 16 7 14 6 12 5 5 10 4 8 Axis Title Axis 3 6 2 4 1 2 0 0 Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8 U.S. Non-Provisional Patents Issued As of Quarter One – FY 2018
U.S. Non-Provisional Patents Issued 3.5 9
8 8 3 7 2.5 6 2 5
1.5 4 Quarterly 1 3 1 2 0.5 1 0 0 Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9 License/Option Agreements As of Quarter One – FY 2018
License/Option Agreements Executed 6 14
5 12 12
10 4 3 8 3 6
Quarterly 2 2 4
1 2
0 0 Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10 Royalty Revenue As of Quarter One – FY 2018
Royalty Revenue 200,000 350,000 180,000 288,752.04 300,000 160,000 140,000 250,000 120,000 200,000 100,000 150,000
Quarterly 80,000
60,000 100,000 40,000 50,000 20,000 13,240.07 7,246.82 - - Q1 Q2 Q3 Q4
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11 FY 2018 Monthly Report of Awards to Date as of September 30, 2017 Summary By Campus FY 2017 FY 2018 Campus Award Count Award Amount Award Count Award Amount $ Change % Change Hawai'i Community College 1 44,800 3 434,919 390,119 870.8% Honolulu Community College 5 2,167,392 4 951,167 (1,216,225) -56.1% Kapi'olani Community College 9 4,715,884 9 3,705,770 (1,010,114) -21.4% Kaua'i Community College 6 1,976,851 3 877,867 (1,098,984) -55.6% Leeward Community College 6 3,612,346 4 3,007,777 (604,569) -16.7% University of Hawai'i Maui College 11 3,879,931 19 9,730,282 5,850,351 150.8% Windward Community College 16 6,543,739 12 5,866,248 (677,491) -10.4% Subtotal Community Colleges and UH Maui College 54 22,940,943 54 24,574,030 1,633,087 7.1% University of Hawai'i at Hilo 45 6,089,502 65 7,486,410 1,396,908 22.9% University of Hawai'i at Manoa 522 130,373,737 528 113,846,555 (16,527,182) -12.7% University of Hawai'i at West O'ahu 10 5,381,172 11 5,147,044 (234,128) -4.4% University of Hawai'i System 26 16,859,149 24 15,627,721 (1,231,428) -7.3% Grand Total 657 181,644,503 682 166,681,760 (14,962,743) -8.2%
FY 2018 Monthly Report of Awards to Date as of September 30, 2017 Campus Details FY 2017 FY 2018 Campus Award Count Award Amount Award Count Award Amount $ Change % Change Hawai'i Community College 1 44,800 3 434,919 390,119 870.8% Chancellor, Hawaii Community College 1 44,800 3 434,919 390,119 870.8% Academic Affairs (Hawaii CC) - - 2 384,919 384,919 100.0% Office of Continuing Education & Training - - 1 50,000 50,000 100.0% UH Center at West Hawai'i 1 44,800 - - (44,800) -100.0% Honolulu Community College 5 2,167,392 4 951,167 (1,216,225) -56.1% Chancellor, Honolulu Community College 5 2,167,392 4 951,167 (1,216,225) -56.1% Academic Affairs (Honolulu CC) 1 486,303 1 576,039 89,736 18.5% Chancellor, Honolulu Community College 1 237,198 2 325,128 87,930 37.1% Natural Sciences 2 1,318,891 - - (1,318,891) -100.0% Pacific Center for Advanced Technology Training 1 125,000 - - (125,000) -100.0% University College - - 1 50,000 50,000 100.0% Kapi'olani Community College 9 4,715,884 9 3,705,770 (1,010,114) -21.4% Chancellor, Kapiolani Community College 9 4,715,884 9 3,705,770 (1,010,114) -21.4% Academic Affairs (KCC) 1 494,973 - - (494,973) -100.0% Arts and Sciences Academic Program 1 999,997 - - (999,997) -100.0% Chancellor, Kapiolani Community College 2 2,716,971 3 2,841,211 124,240 4.6% Continuing Education / Non-Credit Program 1 64,749 - - (64,749) -100.0% Culinary Arts (KCC) 1 14,994 2 132,756 117,762 785.4% Emergency Medical Services 1 149,480 1 149,480 - 0.0% Emergency Medical Technician - - 1 240,000 240,000 100.0% Office for Institutional Effectiveness - - 1 2,000 2,000 100.0% Office of International Affairs 1 1,037 - - (1,037) -100.0% Student Support Services 1 273,683 1 340,323 66,640 24.3% Kaua'i Community College 6 1,976,851 3 877,867 (1,098,984) -55.6% Chancellor, Kauai Community College 6 1,976,851 3 877,867 (1,098,984) -55.6% Chancellor, Kauai Community College 6 1,976,851 3 877,867 (1,098,984) -55.6% Leeward Community College 6 3,612,346 4 3,007,777 (604,569) -16.7% Chancellor, Leeward Community College 6 3,612,346 4 3,007,777 (604,569) -16.7% Chancellor, Leeward Community College 6 3,612,346 4 3,007,777 (604,569) -16.7% University of Hawai'i at Hilo 45 6,089,502 65 7,486,410 1,396,908 22.9% Chancellor, UH Hilo 2 851,640 4 1,683,215 831,575 97.6% Chancellor, UH Hilo 2 851,640 4 1,683,215 831,575 97.6% College of Agriculture, Forestry and Natural Resource Mgt 6 875,262 7 526,513 (348,749) -39.8% College of Agriculture, Forestry and Natural Resource Mgt 4 831,057 4 255,454 (575,603) -69.3% Pacific Aquaculture and Coastal Resources Ctr 2 44,205 3 271,059 226,854 513.2% College of Arts and Sciences 10 1,735,713 12 1,214,878 (520,835) -30.0% Anthropology (UH Hilo) 1 3,260 - - (3,260) -100.0% Biology (UH Hilo) 2 150,000 3 240,527 90,527 60.4% College of Arts and Sciences 1 275,000 1 300,000 25,000 9.1% Geography (UH Hilo) 1 12,534 1 165,000 152,466 1216.4% Marine Science - - 1 24,373 24,373 100.0% Mathematics (UH Hilo) - - 1 7,000 7,000 100.0% Natural Sciences Division 5 1,294,919 3 282,466 (1,012,453) -78.2% Physics and Astronomy - - 1 95,512 95,512 100.0% Social Sciences Division - - 1 100,000 100,000 100.0% College of Continuing Education and Community Svc - - 1 7,750 7,750 100.0% College of Continuing Education and Community Svc - - 1 7,750 7,750 100.0% College of Pharmacy 5 437,217 5 123,660 (313,557) -71.7% College of Pharmacy 2 34,770 2 36,260 1,490 4.3% Pharmaceutical Sciences 2 387,922 2 47,400 (340,522) -87.8% Pharmacy Practice 1 14,525 1 40,000 25,475 175.4% Hawaii Small Business Development Center 2 87,050 - - (87,050) -100.0% Hawaii Small Business Development Center 2 87,050 - - (87,050) -100.0% Imiloa Astronomy Center Of Hawaii 2 118,553 4 174,645 56,092 47.3% Imiloa Astronomy Center Of Hawaii 2 118,553 4 174,645 56,092 47.3% Ka Haka'Ula O Ke'Elikolani-UHH 2 364,140 3 1,574,437 1,210,297 332.4% Hale Kuamo'o Center - - 1 634,437 634,437 100.0% Ka Haka'Ula O Ke'Elikolani-UHH 2 364,140 2 940,000 575,860 158.1% Vice Chancellor for Administrative Affairs - - 1 2,250 2,250 100.0% Vice Chancellor for Administrative Affairs - - 1 2,250 2,250 100.0% Vice Chancellor for Research 11 544,944 19 1,131,322 586,378 107.6% Vice Chancellor for Research 11 544,944 19 1,131,322 586,378 107.6% Vice Chancellor for Student Affairs 5 1,074,983 9 1,047,740 (27,243) -2.5% Center For Gifted And Talented Native Hawaiian Children - - 1 44,800 44,800 100.0% Upward Bound 3 772,500 - - (772,500) -100.0% Vice Chancellor for Student Affairs 2 302,483 8 1,002,940 700,457 231.6% University of Hawai'i at Manoa 522 130,373,737 528 113,846,555 (16,527,182) -12.7% College of Arts and Humanities 4 286,063 8 330,325 44,262 15.5% American Studies - - 2 104,618 104,618 100.0% History (UH Manoa) - - 1 52,777 52,777 100.0% Music (UH Manoa) - - 1 5,930 5,930 100.0% Philosophy (UH Manoa) 1 255,818 1 150,000 (105,818) -41.4% Theatre and Dance 2 8,245 - - (8,245) -100.0% UHM Uehiro Academy for Philosophy and Ethics in Education 1 22,000 3 17,000 (5,000) -22.7% College of Education 23 7,102,610 18 4,240,380 (2,862,230) -40.3% Center on Disability Studies/University Affiliated Pgms 15 5,085,052 9 2,506,372 (2,578,680) -50.7% College of Education 1 68,134 2 265,000 196,866 288.9% Curriculum Research and Development Group 4 1,410,818 2 330,103 (1,080,715) -76.6% Department of Kinesiology and Rehabilitation Science 2 305,510 2 230,500 (75,010) -24.6% Department of Special Education 1 233,096 2 498,074 264,978 113.7% Institute for Teacher Education - - 1 410,331 410,331 100.0% College of Engineering 14 1,524,463 12 1,882,869 358,406 23.5% Civil and Environmental Engineering 3 102,239 7 1,000,709 898,470 878.8% College of Engineering 1 494,802 2 749,160 254,358 51.4% Electrical Engineering 7 608,373 - - (608,373) -100.0% Mechanical Engineering 3 319,049 3 133,000 (186,049) -58.3% College of Language, Linguistics and Literature 12 1,246,133 16 1,361,084 114,951 9.2% Center for Language and Technology 2 4,170 2 16,339 12,169 291.8% College of Language, Linguistics and Literature 1 174,700 1 174,700 - 0.0% Department of East Asian Languages and Literature 3 888,392 3 917,073 28,681 3.2% Department of English - - 3 6,200 6,200 100.0% Department of Linguistics 6 178,871 6 246,260 67,389 37.7% Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 100.0% College of Natural Sciences 79 7,191,634 73 7,062,436 (129,198) -1.8% Department of Biology (Biology Program) 5 110,476 5 739,495 629,019 569.4% Department of Botany 54 4,951,402 50 5,090,767 139,365 2.8% Department of Chemistry 2 236,505 4 260,028 23,523 9.9% Department of Mathematics 3 565,355 3 286,345 (279,010) -49.4% Department of Microbiology - - 1 540 540 100.0% Department of Physics and Astronomy 10 875,899 7 494,915 (380,984) -43.5% Information and Computer Sciences 5 451,997 3 190,346 (261,651) -57.9% College of Social Sciences 23 7,576,977 30 8,770,104 1,193,127 15.7% Department of Anthropology 2 71,949 1 226,267 154,318 214.5% Economics (UH Manoa) 1 46,072 5 242,905 196,833 427.2% Geography (UH Manoa) 2 142,178 4 247,210 105,032 73.9% Psychology (UH Manoa) 4 827,582 3 1,082,845 255,263 30.8% School of Communications 2 36,167 1 5,000 (31,167) -86.2% Social Science Research Institute 10 1,450,529 13 1,803,877 353,348 24.4% Social Sciences Public Policy Center 1 2,500 - - (2,500) -100.0% Urban and Regional Planning 1 5,000,000 3 5,162,000 162,000 3.2% College of Tropical Agriculture and Human Resources 40 4,474,105 49 5,711,889 1,237,784 27.7% Center on the Family 3 329,750 2 230,000 (99,750) -30.3% College of Tropical Agriculture and Human Resources 2 66,907 6 703,867 636,960 952.0% Cooperative Extension - - 3 716,464 716,464 100.0% Family and Consumer Sciences 3 212,122 2 130,647 (81,475) -38.4% Hawaii County 2 31,140 3 471,608 440,468 1414.5% Human Nutrition, Food and Animal Sciences 4 267,797 3 87,439 (180,358) -67.3% Maui County 2 83,347 2 153,197 69,850 83.8% Molecular Biosciences and Bioengineering - - 1 75,000 75,000 100.0% Natural Resources and Environmental Mgt 7 437,752 4 176,275 (261,477) -59.7% Oahu County 1 100,000 1 23,496 (76,504) -76.5% Office of The Assoc Dean for Academic and Student Affairs - - 1 124,630 124,630 100.0% Plant and Environmental Protection Sciences 13 2,782,526 18 2,729,091 (53,435) -1.9% Tropical Plant and Soil Science 3 162,764 3 90,175 (72,589) -44.6% Hawai'inuiakea School of Hawaiian Knowledge 4 1,905,279 3 2,173,074 267,795 14.1% Hawai'inuiakea School of Hawaiian Knowledge 4 1,905,279 3 2,173,074 267,795 14.1% Institute for Astronomy 18 6,394,192 14 7,256,200 862,008 13.5% Institute for Astronomy 18 6,394,192 14 7,256,200 862,008 13.5% John A. Burns School of Medicine 80 33,578,908 58 13,792,197 (19,786,711) -58.9% Department of Anatomy, Biochemistry, and Physiology 1 319,398 1 77,000 (242,398) -75.9% Department of Cell and Molecular Biology 3 3,208,889 2 2,350,280 (858,609) -26.8% Department of Complementary and Alternative Medicine 5 2,257,892 8 2,419,581 161,689 7.2% Department of Family Medicine and Community Health 3 1,090,000 3 2,050,100 960,100 88.1% Department of Geriatric Medicine 4 1,884,265 1 38,275 (1,845,990) -98.0% Department of Medicine 18 4,288,337 9 720,025 (3,568,312) -83.2% Department of Native Hawaiian Health 4 430,445 3 376,312 (54,133) -12.6% Department of Obstetrics, Gynecology and Women's Health 9 4,589,243 6 578,374 (4,010,869) -87.4% Department of Pediatrics 9 4,255,760 4 780,989 (3,474,771) -81.6% Department of Psychiatry 3 3,220,006 1 56,331 (3,163,675) -98.3% Department of Surgery 9 1,940,386 - - (1,940,386) -100.0% Department of Tropical Medicine, Medical Micro and Pharm 8 3,194,603 13 1,955,921 (1,238,682) -38.8% Institute for Biogenesis Research 2 2,197,975 - - (2,197,975) -100.0% John A. Burns School of Medicine 1 19,204 6 1,710,009 1,690,805 8804.4% Native Hawaiian Center of Excellence 1 682,505 1 679,000 (3,505) -0.5% Lyon Arboretum 3 154,194 1 13,000 (141,194) -91.6% Lyon Arboretum 3 154,194 1 13,000 (141,194) -91.6% Office of Research Compliance - - 1 49,900 49,900 100.0% Animal and Veterinary Services Program - - 1 49,900 49,900 100.0% Outreach College 2 3,700 4 35,750 32,050 866.2% Community Programs 2 3,700 3 7,750 4,050 109.5% Outreach College - - 1 28,000 28,000 100.0% School of Architecture 1 146,146 1 150,175 4,029 2.8% School of Architecture 1 146,146 1 150,175 4,029 2.8% School of Nursing and Dental Hygiene 2 931,975 7 1,411,017 479,042 51.4% Department of Nursing 2 931,975 5 1,324,566 392,591 42.1% School of Nursing and Dental Hygiene - - 2 86,451 86,451 100.0% School of Ocean and Earth Science and Technology 156 33,831,515 161 42,728,583 8,897,068 26.3% Center for Microbial Oceanography, Research and Edu (C-MORE) 2 1,229,934 7 3,831,803 2,601,869 211.5% Department of Atmospheric Sciences 4 2,961,949 1 75,174 (2,886,775) -97.5% Department of Geology and Geophysics 8 1,096,473 6 490,472 (606,001) -55.3% Department of Ocean and Resources Engineering 1 493,000 4 466,280 (26,720) -5.4% Department of Oceanography 18 5,241,733 19 3,200,810 (2,040,923) -38.9% Hawaii Institute of Geophysics and Planetology (HIGP) 35 3,699,777 32 4,146,370 446,593 12.1% Hawaii Institute of Marine Biology (HIMB) 12 933,030 15 2,045,252 1,112,222 119.2% Hawaii Natural Energy Institute (HNEI) 2 343,792 5 2,438,997 2,095,205 609.4% International Pacific Research Center (IPRC) 4 499,639 5 1,338,162 838,523 167.8% Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14,321,426 46 19,167,255 4,845,829 33.8% Pacific Biosciences Research Center 5 357,273 5 287,414 (69,859) -19.6% School of Ocean and Earth Science and Technology 4 1,322,000 4 3,219,375 1,897,375 143.5% Sea Grant College Program 11 1,331,489 12 2,021,219 689,730 51.8% School of Pacific and Asian Studies 3 687,250 7 1,576,250 889,000 129.4% Center for Japanese Studies 1 219,850 2 571,350 351,500 159.9% Center for Korean Studies - - 1 20,000 20,000 100.0% Center for Pacific Islands Studies 1 228,000 2 405,000 177,000 77.6% Center for Southeast Asian Studies 1 239,400 2 579,900 340,500 142.2% School of Social Work 9 1,049,935 10 1,916,044 866,109 82.5% Center on Aging 1 14,983 1 86,231 71,248 475.5% Dept of Public Health Sciences and Epidemiology 2 44,488 2 144,018 99,530 223.7% Office of Public Health Studies 3 934,820 6 1,619,765 684,945 73.3% School of Social Work 3 55,644 1 66,030 10,386 18.7% Shidler College of Business 1 210,000 - - (210,000) 100.0% Department of Management and Industrial Relations 1 210,000 - - (210,000) -100.0% University of Hawaii Cancer Center 26 17,463,289 26 6,259,247 (11,204,042) -64.2% Cancer Etiology 13 8,707,637 9 1,281,094 (7,426,543) -85.3% Clinical Sciences 5 6,583,740 9 1,704,424 (4,879,316) -74.1% Natural Products 4 428,402 2 316,921 (111,481) -26.0% University of Hawaii Cancer Center 4 1,743,510 6 2,956,808 1,213,298 69.6% Vice Chancellor, Academic Affairs 1 47,419 7 1,173,822 1,126,403 2375.4% Graduate Education - - 1 695,000 695,000 100.0% Library (UH Manoa) 1 47,419 4 52,081 4,662 9.8% Service Learning - - 1 22,886 22,886 100.0% Undergraduate Education - - 1 403,855 403,855 100.0% Vice Chancellor, Admin, Finance and Operations 1 4,807 - - (4,807) -100.0% Buildings & Grounds Management 1 4,807 - - (4,807) -100.0% Vice Chancellor, Students 10 4,215,318 7 1,506,192 (2,709,126) -64.3% Health & Wellness - - 1 25,000 25,000 100.0% Student Equity Excel & Diversity 9 4,140,318 6 1,481,192 (2,659,126) -64.2% Women's Center 1 75,000 - - (75,000) -100.0% Water Resources Research Center 3 99,302 5 3,451,718 3,352,416 3376.0% Water Resources Research Center 3 99,302 5 3,451,718 3,352,416 3376.0% William S. Richardson School of Law 7 248,523 10 994,299 745,776 300.1% William S. Richardson School of Law 7 248,523 10 994,299 745,776 300.1% University of Hawai'i at West O'ahu 10 5,381,172 11 5,147,044 (234,128) -4.4% Chancellor, UH West Oahu 10 5,381,172 11 5,147,044 (234,128) -4.4% Chancellor, UH West Oahu 3 2,119,104 3 2,059,769 (59,335) -2.8% Division of Social Sciences 2 231,326 4 714,553 483,227 208.9% General Business Administration 1 424,088 - - (424,088) -100.0% General Public Administration 1 328,000 - - (328,000) -100.0% Vice Chancellor for Student Affairs 3 2,278,654 4 2,372,722 94,068 4.1% University of Hawai'i Maui College 11 3,879,931 19 9,730,282 5,850,351 150.8% Chancellor, UH Maui College 11 3,879,931 19 9,730,282 5,850,351 150.8% Academic Affairs (UH Maui College) - - 1 2,000,000 2,000,000 100.0% Allied Health Department - - 1 1,100 1,100 100.0% Chancellor, UH Maui College 2 1,139,764 13 4,285,067 3,145,303 276.0% Culinary Arts (UH Maui College) 1 45,000 - - (45,000) -100.0% General Education 1 800,000 1 800,000 - 0.0% Human Services (UH Maui College) - - 1 1,883,888 1,883,888 100.0% Music (UH Maui College) 1 500,000 1 500,000 - 0.0% Non-Credit Programs (UH Maui College) 1 20,000 - - (20,000) -100.0% Student Affairs (UH Maui College) 4 1,341,034 1 260,227 (1,080,807) -80.6% University of Hawaii Center, Maui 1 34,133 - - (34,133) -100.0% University of Hawai'i System 26 16,859,149 24 15,627,721 (1,231,428) -7.3% Office of the Vice President for Community Colleges 1 182,847 2 1,224,959 1,042,112 569.9% Office of the Vice President for Community Colleges 1 182,847 2 1,224,959 1,042,112 569.9% Office of the Vice President for Research and Innovation 8 796,326 7 2,854,065 2,057,739 258.4% Applied Research Laboratory 7 776,326 7 2,854,065 2,077,739 267.6% Office of the Vice President for Research and Innovation 1 20,000 - - (20,000) -100.0% Office of the VP for Academic Planning and Policy 5 7,232,728 7 3,336,450 (3,896,278) -53.9% Hawai'i P-20 Partnerships for Education Office 1 23,750 6 3,236,450 3,212,700 13527.2% Office of the VP for Academic Planning and Policy 4 7,208,978 1 100,000 (7,108,978) -98.6% Office of the VP for Information Tech/Chief Info Officer 11 8,642,248 8 8,212,247 (430,001) -5.0% Maui High Performance Computing Center (MHPCC) 4 2,700,991 - - (2,700,991) -100.0% Office of the VP for Information Tech/Chief Info Officer 2 157,459 3 1,955,560 1,798,101 1141.9% Pacific Disaster Center 5 5,783,798 5 6,256,687 472,889 8.2% VP For Administration 1 5,000 - - (5,000) -100.0% VP For Administration 1 5,000 - - (5,000) -100.0% Windward Community College 16 6,543,739 12 5,866,248 (677,491) -10.4% Chancellor, Windward Community College 16 6,543,739 12 5,866,248 (677,491) -10.4% Academic Affairs (Windward CC) 1 49,975 - - (49,975) -100.0% Chancellor, Windward Community College 15 6,493,764 12 5,866,248 (627,516) -9.7% Grand Total 657 181,644,503 682 166,681,760 (14,962,743) -8.2% FY18 Q1 Extramural Awards Report
I. Summary
The University of Hawai‘i (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (9.6%), and short of the FY18 Q1 forecast by around $11 million (6.3%). A second underperforming quarter in a row gives one pause as the University enters Q2, which is historically one of its slower growth quarters.
II. Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (9.6%) of FY17 Q1. The performance was on par with FY14 Q1 and FY16 Q1, in which both fiscal years ended better than FY 17 despite FY 17’s promising start. As the second underperforming quarter in a row, this is a solemn reminder that Q2 is usually one of the University’s slower growth quarters, which brings about uncertainties. Hopefully, resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2.
Quarterly Extramural Awards $ millions 2011 2012 2013 2014 2015 2016 2017 2018 Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
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III. Significant Awards by Campus
During FY18 Q1, UH received 682 awards from 217 different sponsors. The following table reports the largest awards received this quarter by campus:
Campus Sponsor Type Sponsor Project Title Amount Department of Homeland National Disaster Preparedness Mānoa Federal Security Training Center 5,000,000 Department of UH Hilo and HawCC Cooperative Hilo Federal Education Arrangement Development Grant 830,715 Department of UH West Oahu PIKO: Po o, Ike, Kino, West O‘ahu Federal Education and Ohana Project 2,000,000 Business and Kamehameha UH West Hawaii Kulike Success Hawai‘i CC Other Schools Through College Readiness 229,878 Ho'ala hou - Renewing a Pathway to Department of Student Success Through Culture-Based Honolulu CC Federal Education Learning 576,039 Strengthening Kapiolani’s Campus and Culture for Student Success: Kauhale Department of Ke Kuleana, the Responsibility of the Kapi‘olani CC Federal Education Whole Village 1,970,810 Department of Kaua‘i CC Federal Education Crossing Cultures 831,167 Department of Pa'a Ke Kahua: Strengthening Our Leeward CC Federal Education Foundation 1,998,368 Akeakamai I Ka La Hiki Ola: Scientific National Science Exploration Beneath The Life-Bringing Maui College Federal Foundation Sun (NSF ATST Mitigation Plan) 2,000,000 Hanaiaulu: Feed and Grow, Nurturing Student Parents and STEM at Department of Windward Community College through Windward CC Federal Education Renovation 1,989,018 Department of Managing Partner of Pacific Disaster UH System1 Federal Defense Center 3,621,979
These projects were also identified as UH Mānoa, UH West O‘ahu, Kapi‘olani Community College, Kaua‘i Community College, Leeward Community College, and Windward Community College’s largest awards in FY17 Q1 as well. In fact, the vast majority of the projects on this table are continuations of prior awards. While this reflects steady revenue, the lack of large, new projects continues to affect overall results.
IV. Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other. Thus, the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level.
1 UH System represents units under Vice Presidents that receive extramural funding. Examples include the P20 and Gear Up grants under the VP for Academic Affairs; Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology; Applied Research Laboratory task orders under the VP for Research and Innovation; and the Pacific Business Center Program under the VP for Community Colleges. 2
Q1 Award Amounts by Location $ millions 2018-17 Campus 2015 2016 2017 2018 Change2 Mānoa 138 122 130 112 -13.2% Hilo 11 7 6 7 25.0% West O‘ahu 3 5 5 5 -5.2% Hawai‘i CC 2 0 0 0 870.8% Honolulu CC 0 2 2 1 -55.8% Kapi‘olani CC 3 3 5 4 21.4% Kaua‘i CC 1 1 2 1 -55.6% Leeward CC 3 3 4 3 -16.7% Maui College 6 7 4 10 149.5% Windward CC 4 4 6 6 -10.4% UH System 21 10 18 15 -17.3% TOTAL 191 166 182 164 -9.6%
Major dollar increases and decreases are attributed as follows:
UH Mānoa – Federal Awards
Of the University’s top five (5) federal agencies, UH Mānoa had FY18 Q1 decreases in: 1) the Department of Health and Human Services (HHS), which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI); 2) the Department of Education (ED); and 3) the National Science Foundation (NSF).
Q117 to Q118 Agency Q115 Q116 Q117 Q118 Decrease HHS 39.7m 30.3m 30.1m 17.3m -12.8m/-42.4% ED 8.1m 11.2m 10.4m 7.5m -2.8m/-27.2% NSF 15.0m 16.2m 11.9m 8.9m -2.9m/-24.8%
Department of Health and Human Services (HHS)
The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A. Burns School of Medicine and the UH Cancer Center.
Q117 to Q118 Unit Q115 Q116 Q117 Q118 Decrease School of Medicine 18.6m 14.5m 18.0m 8.9m -8.3m/-48.2% UH Cancer Center 15.1m 12.7m 10.7m 4.9m -5.8m/-54.3%
• John A. Burns School of Medicine: Unlike FY17 Q1, which had twelve (12) awards over $500,000 (total $14.2 million), FY18 Q1 had seven (7) awards over $500,000 (total $6.7 million). Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $8.5 million) were incremental funding.
2 The percent change over the prior year is calculated using the actual figures not the rounded figures.
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• UH Cancer Center: Unlike FY17 Q1, which had five (5) awards over $500,000 (total $9.1 million), FY18 Q1 had three (3) awards over $500,000 (total $3.6 million). Four (4) of the five (5) awards in FY17 Q1 (totaling $8.5 million) were incremental funding. • In our FY17 Q4 report, we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17. There is a possibility that timing of incremental funding will affect their overall FY 18 results.
Department of Education (ED)
The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education.
Q117 to Q118 Unit Q115 Q116 Q117 Q118 Decrease College of Education 3.6m 3.3m 4.0m 1.7m -2.4m/-58.8%
Compared to FY17 Q1, which had seven (7) awards over $500,000 (totaling $5.9 million), FY18 Q1 had one (1) award for $547,000. Three (3) of the seven (7) awards in FY17 Q1 (totaling $2.6 million) were increments. Timing issues may also affect FY 18 results.
UH Mānoa – Non-Federal Awards
Compared to FY16 Q1 and FY17 Q1, the School of Medicine received a significant amount less in salary and fringe (S&F) reimbursement agreements from Hawai‘i health organizations. There are approximately $5 million in pending agreements in Q2, which means that timing issues are affecting quarterly results.
S&F Reimb. Agreements Q116 Q117 Q118 Dollar amount $10.9m $13.1m $824K % of fiscal year total 93.2% 99.6% TBD
UH Maui College
Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1:
• $2 million in incremental funding for the NSF “ATST Mitigation Plan.” Note that no increments were received in FY 17, but two (2) increments totaling $4 million were received in FY 16. • $1.8 million in supplemental funding for the Hawai‘i Department of Human Services “Hawai‘i Child Welfare Continuous Quality Improvement Project.” Note that in FY 17, the supplement was received in Q2 as opposed to Q1. Thus, the increase is due to timing of the award in FY 18. • Two (2) new awards from the NSF: 1) “CSP4Hawaii: Deployment of Computer Science Principles Courses within Secondary Schools in Hawai‘i” totaling $999,239;
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2) and “Collaborative Research: Examining the Impact of an Industry-aligned, STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Development” totaling $720,763.
UH System
• Unlike FY17 Q1, where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award, there was no award of comparable size in FY18 Q1. • Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases: 1) “InfraRed Celestial Reference Frame Observations Using the United Kingdom InfraRed Telescope (UKIRT)” totaling $700,000; 2) and “Research and Development for DoD Vanguard Center of High Performance Computing” for $1.2 million.
V. Forecast vs. Actuals
The FY18 Q1 results were approximately $11 million short (6.3%) of the forecasted amount. Like FY17 Q4 where the seasonal state and local government increases did not occur, the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4), which affected results.
Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years. Nevertheless, the FY 18 forecast will remain at $408 million.
FY 2018 Forecast Actual Variance Q1 175 164 -6.3% Q2 74 — TBD Q3 57 — TBD Q4 102 — TBD Total 408 164
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UNIVERSITY OF HAWAI‘I CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F. Holcombe, MD, MBA November 1, 2017
Accelerating cures through cancer research in Hawai‘i The mission of the University of Hawai‘i Cancer Center is to reduce the burden of cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural and environmental characteristics of Hawai‘i and the Pacific. Grant funding by UH Cancer Center members Funding success rate UH Cancer Center and Education
• Summer Internship program • Graduate student education • Educating local science teachers • SOCRA training for CRAs • Training grants UH Cancer Center and Community Outreach
• Community events – 14 over past year focused specifically on the community • Seminars – Over 160 this past year, many open to the public • State Cancer Plan – Involvement with development of plan in conjunction with the DOH Partnerships and Collaborations
Hawai‘i Cancer Consortium Trans-Pacific Partnership for Cancer Prevention Public Relations • 100 news articles in print, broadcast or electronic media over this past year Faculty recognitions Clinical trials for patients with cancer or at risk for cancer • 2336 patients enrolled onto trials in 2016 – 354 treatment trials – 177 other interventional trials – 1805 observational trials • High proportion of racial and ethnic minority accrual – Includes specific studies focused on Native Hawaiians who experience significant cancer health disparities Operating budget projected to UH Cancer Center Operating Margin balance in FY2018 1,000,000.00 -
(1,000,000.00)
(2,000,000.00)
(3,000,000.00)
(4,000,000.00)
(5,000,000.00)
(6,000,000.00)
(7,000,000.00)
(8,000,000.00) Future opportunities
• Retain NCI designation • Clinical trials initiatives • Build out of UH Cancer Center Annex • Institute for Ethnic Diversity and Cancer Health Disparities • Faculty recruitment – Microbiome and cancer – Cancer Imaging – Cancer prevention – Cancer Immunology
University of Hawai‘i Cancer Center
Annual Report
Board of Regents, Research & Innovation Committee Randall F. Holcombe, MD, MBA November 1, 2017
EXECUTIVE SUMMARY
This report summarizes some of the most important activities, initiatives and accomplishments of the UH Cancer Center from October 1, 2016 through October 1, 2017.
• UH Cancer Center focuses on its mission o Cancer Center faculty have worked collaboratively over the past year to achieve its mission to reduce the burden of cancer through research, education, patient care and community outreach. • Success of UH Cancer Center members in obtaining extramural funding o The grants portfolio of UH Cancer Center members has increased over the past 5 years with $41 million in total extramural funds in 2016. The amount grant funding for proposals submitted in 2017 is a 20% increase over 2016. The success rate for grant funding by UH Cancer Center members is nearly double the national average. • Cancer Center involvement in education o UH Cancer Center continues to be involved in graduate student education, summer research internships and a myriad of other instructional and training activities. • Community outreach and engagement o UH Cancer Center members are committed to community education about cancer and outreach activities focused on cancer prevention, screening, detection and treatment. • Partnerships o With reengagement of Hawai‘i Cancer Consortium (HCC) partners and efforts to focus HCC activities on the clinical research infrastructure, the HCC has agreed to extend the term of the affiliation an additional year to 2019. UH Cancer Center has also established a new Trans-Pacific Partnership for Cancer Prevention to promote cancer prevention and control research across the Pacific. • Public relations o Extensive local print, broadcast and on-line media coverage of UH Cancer Center over the past year has been 100% positive. • Faculty recognitions o Numerous UH Cancer Center faculty have received national and international recognitions over the past year. • Clinical trials for cancer patients o UH Cancer Center provides a clinical trials infrastructure facilitating access for over 2/3 of the cancer patients in the State, with oversight of trials at Queens Medical System, HPH hospitals, Kuakini Health System and numerous private practice sites on O‘ahu. UH Cancer Center has a specific focus to provide trials relevant to Native Hawaiians and other racial and ethnic groups with cancer health disparities. • Faculty recruitments o Several new faculty have been recruited over the past year in support of the Cancer Center missions, including two academic clinicians. • UH Cancer Center will have a balanced operating budget in 2018 o The Cancer Center is very appreciative of the current UH Mānoa leadership that has recognized an 8 year history of insufficient general funds support to the Cancer Center, in comparison to other research and academic units, and has provided resources to partially correct this inequity. This, in combination with support from the Governor, who recognized the substantial reduction of State funding that has arisen because of reduced cigarette tax revenues, and with improved internal fiscal management, UH Cancer Center has erased an operating deficit that was over $7 million in FY 2016.
UH Cancer Center Focuses on its Mission The mission of the University of Hawai‘i Cancer Center is to reduce the burden of cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural and environmental characteristics of Hawai‘i and the Pacific. The past year has been exemplified by the Cancer Center faculty working collaboratively toward achieving this mission through the following goals: 1. Support basic and translational cancer-focused research that contributes to a biological understanding of cancer among diverse racial and ethnic groups, harnesses the opportunities for discovery from natural products present within the unique environment of our catchment area, and translate innovations to the benefit of individuals with, or at high risk for, cancer. 2. Support population-based research that enhances an understanding of the occurrence and outcomes of cancer among diverse racial and ethnic groups, identifies approaches to meaningfully intervene to reduce the burden of cancer within the catchment area, address cancer health disparities such as those found among Native Hawaiians, and informs the public and policy makers regarding cancer risk and prevention. 3. Support an infrastructure to translate discovery to clinical and public health practice, facilitate access to novel cancer clinical, prevention and community trials, and engage the medical community, and the community at large, in order to advance the science and practice of cancer risk assessment, cancer prevention, cancer treatment, and cancer healthcare delivery. Extraordinary progress toward achieving these goals has been made over the past year. This progress was documented in the Cancer Center Support Grant (P30) application to the National Cancer Institute, submitted September 25, 2017. Seminal Advances in Cancer Research Numerous seminal advances were made this past year by Cancer Center investigators. Many received national recognition. These include: • Carbone/Yang – Unusually high Mesothelioma rate in young women in China (JAMA Oncology) • Carbone/Yang – BAP1 as mechanism for asbestos and sun exposure (UV) related cancers (Nature) • Cassel – No Ke Ola Pono a Nā Kāne project for colon cancer screening among Hawaiian men • Garmire – Single cell cancer bioinformatics (Frontiers in Genetics) • Hernandez/Paulino – Betel nut and oral microbiome in Pacific Islanders (PLOS One) • Jia – Metabolomics and fructose utilization in AML (Cancer Cell) • Matter, Shvetsov, Maskarinec – Native Hawaiians have two-fold higher mortality from cancer associated sepsis (PLOS One) • Park, Boushey, Wilkens, Le Marchand – high quality diet and colorectal cancer across ethnically diverse populations (Gastroenterology) • Ramos – RSK inhibitor for brain tumor treatment (Oncotarget) • Rosser – Novel bladder cancer assay (J Translational Medicine) • Turkson – Stat3 inhibitor for cancer treatment (Leukemia Lymphoma) [compound derived from ironweed found on Hawai‘i Island] • Wilkens/Le Marchand – CYP2A6 polymorphisms and lung cancer (Cancer Research) • Wills – eCigarettes promote later use of combustible cigarettes (JAMA Pediatrics) Establishment of New Capabilities in Genomic Sequencing A collaboration with JABSOM was formalized creating a Kaka‘ako campus Genomics and Bioinformatics Shared Resource (GBSR). The GBSR offers state-of-the-art genomic sequencing with the addition of an Illumina 500 NextGen Sequencer System. The new structure will improve efficiencies and provide enhanced support for researchers across the UH system. New Capabilities in Metabolomics Over the past several years, UH Cancer Center invested in development of a Metabolomics Shared Resource (MeSR) which is now established as one of the premier facilities in the US for this type of research. Led by Dr.
Wei Jia, this facility offers unique support for investigators involved in research on metabolic conditions, nutrition, obesity and cancer. This provides researchers across UH access to cutting edge capabilities in this burgeoning field. Peer-Reviewed Research Publications Over the past year, the 69 UH Cancer Center members published 242 peer-reviewed manuscripts. A very selected listing of some of the most important papers published over the past year is included (Appendix I). Cancer Center Grants Portfolio UH Cancer Center members generate a substantial amount of extramural funding and the total funding received has been increasing. In 2012, total extramural funding for Cancer Center members was slightly over $27 million. In 2016, this had increased to $41 million. 2017 has seen a nearly 20% increase in the number of grants submitted for funding consideration. As of October 6, 2017, total funding submitted in 2017 is $175 million, with $36 million already awarded and $135 million pending a decision from the funding agency. Grant submission and funding information is shown in the Figure, below:
The success rate for funding by UH Cancer Center members has substantially exceeded the success rate for all grants submitted to the National Cancer Institute, nationally, for every year since 2012. This demonstrates the high quality of proposals being submitted by Cancer Center members and the excellence of the research at the UH Cancer Center as measured by objective, national criteria. Note that the high success rate in 2012
includes ARRA funding which is not reflected in the NCI base rate for that year. Cancer Center Involvement in Education and Instruction UH Cancer Center members are active in research training and teaching. This includes mentoring students on research projects, teaching classes at UH Mānoa, and serving as thesis advisor and committee member on master’s and doctoral committees. The majority of UH Cancer Center members have affiliations with departments and graduate programs throughout the UH Mānoa campus including Cell and Molecular Biology (JABSOM), Molecular Biosciences and Bioengineering, Institute for Biogenesis Research (JABSOM), Chemistry, Public Health Studies, Human Nutrition, Psychology and Social Work. In addition to support from grants for research education, UHCC has a direct commitment to education and career enhancement that includes funding of two first year graduate students in the Cancer Biology and in Population Sciences in the Pacific programs. In addition, UHCC provides funds for the Summer Internship Program from the Meiji Foundation ($20,000 per year) and the Friends of the UH Cancer Center ($18,000 per year) to support 9-10 students per year. Finally, over the past 2 years, UHCC has sponsored more than 117 health related conferences for researchers and an additional 27 outreach events for the general public to increase awareness of cancer prevention, detection ad treatment. Summer Internship Program The primary high school and undergraduate educational activity at UHCC is the popular Summer Internship Program, which trains 25 students every year at UH Cancer Center. Support for this Program has come from the Cancer Center P30 CURE supplement which began in 2004, a grant from the Meiji Foundation (since 2002), Friends of the UH Cancer Center (since 2017), and UH Cancer Center institutional funds. Interns sponsored by the P30 CURE supplement are high school or undergraduate students, the interns sponsored by the Meiji Foundation and UHCC funds are undergraduate students. The interns come from local high schools or from colleges in Hawai‘i and the US mainland. From 2012-2017, UHCC provided cancer research training experiences to 135 high school and undergraduate students. On average, nearly 60% of all participants of the Internship Program, and all trainees sponsored by the CURE program, come from ethnic groups who are underrepresented in research or are from disadvantaged backgrounds. From 2004-2016 the participating students sponsored by the Cure Program were comprised of 48% Filipinos, 40% Native Hawaiian/Pacific Islanders, 7% first generation college, 5% Hispanic and 1% African American. Graduate Student Education Around 30 Cancer Center members with a primary appointment at UH Cancer Center participate in research training and teaching activities. These include mentoring of post-doctoral fellows and medical students, direction of cancer-focused journal club series for graduate students and conducting a clinical trials education series primarily targeted toward medical students. Educating Local Science Teachers In December 2016, a workshop with interested high school teachers was held to collect ideas on how UHCC could support science education in high schools during the next five years. The participants generated several ideas for ways UHCC can engage our catchment high schools, identified current issues limiting such engagement, and brainstormed how to assist teachers in designing curricula related to cancer research. Ideas included providing teachers a summer research experience that was constructed to aid curriculum design; engaging counselors and student families in the process to help build a supportive and better-informed community around the High School students doing research projects; and coordinating with the schools to define time blocks for students to do research in the afternoons. Some of these ideas were incorporated into the new R25 YES application (see below). SOCRA Training for Clinical Research Associates The UHCC Clinical Trials Office recently led the establishment of a Hawai‘i chapter of The Society of Clinical Research Associates (SOCRA). SOCRA maintains an International Certification Program to create an internationally-accepted standard of knowledge, education, and experience by which any clinical research
professionals can be recognized as Certified Clinical Research Professionals in the clinical research community. The standards upon which this certification program is based have been set forth by this organization to promote recognition and continuing excellence in the ethical conduct of clinical trials. Prior to the UHCC-led SOCRA chapter in Hawai‘i, there was no formal training and certification program for clinical research associates in the State. Training Grants UHCC has been successful in obtaining extramural funding for education and training. These grants are listed in the Table, below. In addition, two training grant proposals are currently submitted for funding consideration – an R25 grant entitled “Youth Enjoy Science (YES) Research Education Program and a T32 training grant in Epidemiology. Both are submitted to the NCI and are currently under review.
Cancer Center Community Outreach Activities The UH Cancer Center hosts community outreach events throughout the year. These events are open to the general public and are essential to our mission to inform the people of Hawai‘i about the very latest cancer breakthroughs and the latest on how to prevent and treat cancer here. This includes information on new clinical trials. A listing of some of the major events appears in the Table, below:
Community Outreach Events (October 2016 - September 2017)
# of Date Event Title Description of Activity/Event Attendees November 2, Prostate Cancer Community education event 60 2016 Symposium
Objectives for this conference in Kona are: 1) Identify gaps & needs for cancer survivors after treatment and beyond; 2) Journey Together: Identify current statewide and November 4, Helping to Shape Cancer institute/organization specific cancer 100 2016 Survivorship Care in survivorship resources with the goal of Hawaii teaching and sharing what has been successful; and 3) Identify ways to improve communication between cancer survivors, caregivers, and healthcare professionals. November 12, HSCO Clinical Trials Recognition of community providers 100 2016 Participation Awards participating in UHCC clinical trials. The goal of the summit is to understand how our state will be impacted through Hawaii Comprehensive policy, system, and environmental December 14, Cancer Coalition approaches and what we can do to 80 2016 Moonshot Summit 2016 implement the Moonshot vision. This annual Coalition meeting will unveil State Cancer Plan 2016-2020. (see Appendix II) No Ke Ola Pono o Na Annual update on the progress of the No May 19, 2017 Kane 2017 Report to the Ka Ola Pono o Na Kane (for the good health 80 Community of Native Hawaiian men) project. Recognition of patients who have June 3, 2017 HERO Appreciation Event 140 participated in clinical trials July 18, 2017 Tour for JABSOM alumni Tours of the UH Cancer Center 10 Training conducted by Francisco Conde, Clinical Models for PhD, to understand the need for cancer August 11, Survivorship Care Plan survivorship care plans, explore models on 10 2017 Delivery how to implement plans into practice, and discuss challenges with implementation Provide NCI's Cancer Clinical Trials: The In- August 11, JABSOM Community Depth Program and overview of clinical 72 2017 Health & Service Program trials to JABSOM first year medical students. Provide an overview of the Cancer To the Moon and Back to Moonshot, and the impact of the August 18, the Bedside: The Future Moonshot on cancer care, with specific 238 2017 of Cancer Care and references to the oncology professionals in Treatment Hawaii. Program provides attendees with a comprehensive view of current methods in the diagnosis and treatment of breast cancer, pancreatic carcinoma, metastatic 20th Annual West Hawaii September 8, prostate cancer, lung cancer, cancer pain Cancer Symposium & Run 150 2017 management, sentinel node surgery and for Hope Events review challenges in health care. Includes weekend of Run for Hope activities: tennis & golf tournaments, "Taste of Hawaii Island" dinner, and 5K/10K Fun Run. Community based educational event with September 21, 4th Annual Prostate information about prostate cancer 80 2017 Cancer Symposium prevention and treatment September 22, 33rd Hawaii Seniors' Fair Showcases products, services, programs, 20,000 2017 Good Life Expo and organizations with over 275 exhibits.
September 30, Quest for the Cure: Lung Community education about lung cancer 80 2017 Cancer prevention and treatment
State Cancer Plan The State of Hawai‘i has completed its 2016 to 2021 Five Year Comprehensive Cancer Plan with substantial input and leadership from UHCC members. The State of Hawai‘i Comprehensive Cancer Plans (HCCP), similar to other States, Territories, and Tribes, is developed, implemented and evaluated through their respective stakeholder coalitions. The HCCP includes the domains of prevention, screening, treatment, quality of life, data, and research. Much of the data utilized in development of the Plan is derived from the Hawai‘i Tumor Registry, directed by Dr. Brenda Hernandez. Dr. Neal Palafox has been a member of Hawai‘i’s Comprehensive Cancer Coalition since 2010. He served a two-year term as Vice Chair from 2012 to 2013, and a two-year term as Chair from 2014 to 2015. During his tenure as Chair, Dr. Palafox guided the development and writing of the 2016 through 2020 plan with the Hawai‘i State Department of Health. In the current State plan, a major emphasis was placed on addressing the social determinants of health and on cancer health disparities as they relate to cancer prevention and outcomes. Partnerships and Collaborations One of the most important collaborations for the UH Cancer Center is the affiliation of hospitals called the Hawai‘i Cancer Consortium (HCC). The HCC is a 501(c)(3) entity formed to support the Cancer Center, particularly in the area of clinical research. It is comprised of Queens Health System, Hawai‘i Pacific Health hospitals, Kuakini Health System and JABSOM. Over the past year, the expenditures to the Cancer Center from HCC, on recommendation by the UHCC Director, have been adjusted to ensure that they directly address support of the clinical research infrastructure. The Cancer Center has worked to improve access to clinical trials, facilitate the opening of studies, provide improved scientific and regulatory oversight of trials, and enhance the data and safety monitoring capabilities. In recognition of improved value derived from these efforts, the HCC clinical partners recently voted to extend the term of the affiliation into 2019 and each provided a strong letter of support for the NCI Cancer Center Support Grant submission. A new affiliation established over the past year is the Trans-Pacific Partnership for Cancer Prevention (TPPCP). This is an affiliation of institutions, led by the UH Cancer Center, with a mission to improve cancer control and prevention, and promote cancer prevention research, in Hawai‘i and across the Pacific. Charter members of the TPPCP include: • University of Hawai‘i Cancer Center • University of Guam • American Sāmoa Community Cancer Coalition • Hawai‘i Pacific University Public Relations The UH Cancer Center has had extensive coverage in the local print, broadcast and on-line media. In addition, findings from several research studies have received national coverage. After a long period of negative press over the past several years, 100% of the news stories from this past year were positive, highlighting the exceptional research, community outreach and educational activities conducted by UH Cancer Center faculty. In addition, Dr. Holcombe has participated in numerous community forums including Future Focus, the Hawaii Business Roundtable, The State Cancer Control Plan unveiling, The Oncology Nursing Society annual meeting, the Hawaii Book and Music Festival and oncology tumor boards at all of the UH Cancer Center-affiliated hospitals. A partial listing of news stories from this past year is included below: Stories Subtitles/Subject Date Viewers- Visitors KHON Living 808 Cooling Cancer – UH Cancer Center 4-Oct-17 1,657 KITV news this morning UH Cancer Center hosts 7th annual Quest for a Cure 1-Oct-17 14,557 KITV news at 10 UH Cancer Center hosts 7th annual Quest for a Cure 30-Sep-17 12,151
KFVE Hawaii News Now at NINE UH Cancer Center hosts 7th annual Quest for a Cure 30-Sep-17 24,258 Honolulu Star-Advertiser UHM awarded $3.1M for multiethnic cancer research 24-Sep-17 335,202 KITV news at 10 UH Cancer Center hosts 4th Annual Prostate Cancer Forum 20-Sep-17 20,013 Honolulu Star-Advertiser UH granted $3.1 million for cancer research 15-Sep-17 335,202 Honolulu Star-Advertiser Low health risk does not curb dangers of asbestos exposure 2-Sep-17 328,598 Honolulu Star-Advertiser Asbestos risks low for firefighters 16-Aug-17 328,598 The Maui News Maui High graduate spends summer turning raw data into cancer research 14-Aug-17 30,084 Honolulu Star-Advertiser Studies show e-cigs don't help kick habit 13-Aug-17 328,598 Hawaii Tribune-Herald Future scientist: Kea‘au High graduate among UH Cancer Center interns 12-Aug-17 60,169 Big Island Now Summer Interns Conduct Cancer Research in Hawai‘i 7-Aug-17 32,861 Maui Now Former Maui Student Does Cancer Research on Oahu 3-Aug-17 41,220 KITV News at 6 Students conducting impressive research at UH Cancer Center this summer 3-Aug-17 34,300 KHON Fundraiser benefiting UH Cancer Center 31-Jul-17 7,187 KHON-TV [FOX 2] UH Cancer Center study cited in coverage of city bill that would ban smoking 27-Jul-17 144,425 in vehicles in presence of minors KHON-TV [FOX 2] Doctor explains dangers of asbestos as Marco Polo residents raise safety 26-Jul-17 144,425 concerns Honolulu Star-Advertiser Studies link coffee to lower death, disease risks 23-Jul-17 271,359 Honolulu Star-Advertiser Diet affects colorectal cancer risk, UH finds 18-Jul-17 271,359 Honolulu Star-Advertiser Vaping among teens turns up asthma risk 18-Jul-17 271,359 Hawaii News Now Study: Teens using e-cigs more likely to use tobacco products 18-Jul-17 60,060 KITV news at 5 Teens who smoke E-cigarettes are much more likely to smoke tobacco 17-Jul-17 34,734 cigarettes KHON Hawaii at 10 Teens who smoke E-cigarettes are much more likely to smoke tobacco 17-Jul-17 41,488 cigarettes Los Angeles Times Two big studies bolster the claim that coffee even decaf is good for you 11-Jul-17 16,709,826 Forbes Magazine No, These 2 Studies Don't Prove That Coffee Leads to Longer Life 11-Jul-17 38,775,648 Newsweek Magazine Is Coffee Good for you? New Study Shows the Drink may Help People Live 10-Jul-17 8,706,276 longer Even if it's Decaf Ka Leo Cancer center finds gene mutation that makes some more cancer-prone 16-Jun-17 40,611,881 Hawaii News Now UH team's discovery could prove a breakthrough in cancer treatment 14-Jun-17 453,312 KITV news at 10 UH Cancer Center team's discovery could prove a breakthrough in cancer 14-Jun-17 24,170 treatment Herald Tribune Q&A: Enjoy your summer barbecue but in moderation 13-Jun-17 212,468 KITV Television Native Hawaiians at greater risk of developing, dying from cancer-associated 5-Jun-17 115,036 sepsis Washington Post Evidence grows linking grilled meat and cancer, but you can lower the risk 3-Jun-17 34,313,689 KHON Living 808 How volunteering to participate in a clinical trial helps advance medical care 31-May-17 1,657 Honolulu Star-Advertiser Post pictures of your lunch for science 30-May-17 257,660 KHON Channel 2 Morning News Willing to log your food intake? There's an app for that! 24-May-17 7,075 at 5:00 Big News Network UH researcher develops app to lower abdominal fat, focus group applicants 24-May-17 16,366 wanted KGMB Sunrise Willing to log your food intake? There's an app for that! 24-May-17 29,408 KHON Television UH Cancer Center seeks participants in study to reduce abdominal fat 24-May-17 307,762 Hawaii News Now Want to burn belly fat (no fad diet required)? There's a UH app for that 24-May-17 453,312 KITV News at 6 UH Cancer Center seeks participants in study to reduce abdominal fat 23-May-17 39,860 KGMB Hawaii News Now at 5 UH Cancer Center seeks participants in study to reduce abdominal fat 23-May-17 48,751 KITV Television Cancer study finds support group is key for Hawaiian men 21-May-17 115,036 KGMB Hawaii News Now at 10 Cancer study finds support group is key for Hawaiian men 20-May-17 50,468
KHON Television A look at Hawaii’s cancer treatment, research as senator recovers from 18-May-17 307,762 kidney surgery KGMB Hawaii News Now at 6 Sen. Mazie Hirono to undergo treatment for kidney cancer 16-May-17 59,615 KHON Television Sen. Mazie Hirono to undergo treatment for kidney cancer 16-May-17 307,762 Honolulu Star-Advertiser Isles annual death toll from breast cancer is 125, UH Cancer Center report 30-Apr-17 469,403 Honolulu Star-Advertiser $3M grant good news for UH Cancer Center 12-Apr-17 469,403 KGMB UH lab gets $3M to study plant as cancer treatment 9-Apr-17 50,324 KITV Television UH lab gets $3M to study plant as cancer treatment 9-Apr-17 29,897 KHON-TV [FOX 2] UH lab gets $3M to study plant as cancer treatment 9-Apr-17 29,897 Honolulu Star-Advertiser UH lab gets $3M to study plant as cancer treatment 9-Apr-17 469,403 Honolulu Civil Beat Senate Committee Unveils A Streamlines State Budget 30-Mar-17 111 Business Journals UH cancer center, medical school getting energy storage pilot projects 22-Mar-17 4,124,434 KITV Television Native Hawaiians, highest cancer mortality rates 5-Feb-17 KHNL Hawaii News Now at TEN Cancer Center report on Native Hawaiian health 4-Feb-17 23,121 Honolulu Star-Advertiser Investment in Cancer Center will benefit health, economy 4-Feb-17 12,971 Take Charge Parenting E-Cigarettes Luring Non-Smoking Teens to Regular Cigarettes 25-Jan-17 476,786 NewsMaxHealth E-Cigarettes May Lead Teens to Smoke 24-Jan-17 3,179,123 solonews.net Cigarettes may lure teens who otherwise might not smoke 24-Jan-17 403,001 US News & World Report E-Cigarettes Not a Smoking Deterrent for Kids 23-Jan-17 9,536,206 KFVE Hawaii News Now at 6:30 Think About It commentary 17-Jan-17 8,383 KGMB Sunrise UH Cancer Center gives vaccination stats 11-Jan-17 $22,670 asbestos.com Early Detection of Mesothelioma Lies in HMGB1 Isoforms 9-Jan-17 12,971 Honolulu Star-Advertiser Lawmaker has her eye on $6 million 6-Jan-17 330,674 Civil Beat Senators Voice Concerns Over UH Budget Requests 5-Jan-17 4,660 Honolulu Star-Advertiser Cancer Center has $6M nest egg and lawmakers want an accounting 5-Jan-17 330,674 KIPO-FM Hawaii Public Radio on State's cancer plan with interviews from UH Cancer Center Director Dr. 15-Dec-16 KIPO Randall Holcombe KITV Television State's cancer plan with interviews from UH Cancer Center Director Dr. 15-Dec-16 11,246 Randall Holcombe Honolulu Star-Advertiser Ige pledges $10M in states cancer battle plan 15-Dec-16 304,899 KITV Television Gov. Ige pledges $10M to UH Cancer Center as part of state's new battle plan 14-Dec-16 38,009 KFVE Hawaii News Now at NINE UH Wahine volleyball coach Dave Shoji takes leave for cancer treatment 13-Dec-16 29,241 Honolulu Star-Advertiser Bill passed by Congress could aid cancer center 12-Dec-16 304,899 asbestos.com Environmental Asbestos Raises Mesothelioma Among Women 22-Nov-16 16,863 KITV Television Colon cancer kills more Native Hawaiians than any other ethnic group in HI, 21-Nov-16 36,062 UH Cancer Center aims to reverse that trend Honolulu Star-Advertiser Cancer Center budget goes up in smoke 21-Nov-16 304,899 eCancerNews Researcher finds new driver of an aggressive form of brain cancer 16-Nov-16 118,438,873 medicalxpress.com Researchers find new driver of an aggressive form of brain cancer 15-Nov-16 1,999,619 MSN News Vaping may turn teens into heavy cigarette smokers 15-Nov-16 118,438,873 Honolulu Star-Advertiser UH discovery could aid brain cancer care 15-Nov-16 304,899 Latinos Health Regular vaping habit developed by teens may result to heavy smoking later: 12-Nov-16 487,565 Study NBC News Kids who vape more likely to become regular smoker, study finds 8-Nov-16 16,257,519 Business Insider Frequent vaping by teens linked to heavy smoking later 8-Nov-16 32,027,795 healthmedicinet.com Frequent vaping by teens linked to heavy smoking later 8-Nov-16 433,341 Honolulu Star-Advertiser Partnership aims to improve cancer care for isle patients 8-Nov-16 422,755 KSSK-FM Perry and Price 0800am 8-Nov-16
KGMB UH Cancer Center welcomes new director 8-Nov-16 50,219 KITV Television UH Cancer Center welcomes new director 8-Nov-16 155,776 KHON Television UH Cancer Center welcomes new director 8-Nov-16 287,676 Honolulu Star-Advertiser UH cancer researcher wins $4.5M in grants 6-Nov-16 422,755 West Hawaii Today Stakeholders in medical field converge for conference to improve care 5-Nov-16 97,285 Honolulu Star-Advertiser UH to seek $29 million budget boost 4-Nov-16 422,755 eCancerNews New cancer treatment strategy discovered for acute myeloid leukemia 3-Nov-16 751,178 news-medical.net Scientists discover novel therapeutic target and treatment strategy for acute 2-Nov-16 53,337 myeloid leukemia m.medicalxpress.com New cancer treatment strategy discovered for acute myeloid leukemia 2-Nov-16 5,162 Men's Health UH Cancer Center research shows coffee drinkers less likely to develop liver 31-Oct-16 5,758 cancer Honolulu Star-Advertiser Randall Holcombe: Director sees bright future for UH Cancer Center 21-Oct-16 422,755 Honolulu Star-Advertiser Cancer survivors find therapy through blogging, Snapchat 16-Oct-16 422,755 KHON-TV [FOX 2] CoolingCancer.org donates $50K to UH Cancer Center 11-Oct-16 287,676 TOTAL 458,323,563
Faculty Recognitions Numerous UH Cancer Center faculty received national and international recognition over this past year. A summary is included in the Table, below: Faculty Recognition Year
Gertraud Maskarinec Fulbright Global Awardee 2017-2018 Jeffrey Berenberg Mastership for Extraordinary Service from the American College of 2017 Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors Carl-Wilhelm Vogel Overseas fellow of the Royal Society of Medicine, London 2016 Jeffrey Berenberg NCORP Health Care Disparities Working Group 2016-present Jared Acoba NCI Gastrointestinal Cancer Steering Committee 2016-present Randall Holcombe Chair, Physician’s Clinical Leadership Initiative, Association of American 2015-2018 Cancer Institutes Loïc Le Marchand Thomson Reuters “World’s Most Influential Scientific Minds” 2015, 2016
Clinical Trials for Patients with Cancer An important mission of the UH Cancer Center is to provide access to clinical trials for patients with cancer. This is essential because clinical trials provide the highest quality of care available for a cancer patient and it is through this process that improved therapies are developed. Oncology care is changing rapidly; today’s “standard” treatment was a clinical trial 5-10 years ago and today’s clinical trial will in many cases be the “standard” 5-10 years from now. In addition to providing access to cancer clinical trials, the UH Cancer Center focuses on ways to reduce the health disparities experienced by specific populations across Hawai‘i. For example, Native Hawaiians have higher rates of death from cancer than any other racial or ethnic group; UH Cancer Center investigators are working to directly address this disparity through cancer prevention research and community outreach and education. Between 2012 and 2017, over 12,450 patients were enrolled onto UH Cancer Center-sponsored clinical trials. In 2016, over 75% of all enrollments were to non- whites, with Native Hawaiians accounting for 17% of enrollment to treatment trials and 72% of enrollment to other interventional (prevention, diagnosis, screening, etc.) trials. Clinical trials accrual information is depicted in the two Tables, below:
Accrual at UHCC Based on Type of Trial Interventional Non- Interventional Non-Interventional Epi, Obs Accrual Year Total therapeutic Therapeutic and Outcome Studies 2012 191 109 280 580 2013 303 100 2002 2405 2014 623 75 2735 3433 2015 105 76 2577 2758 2016 354 177 1805 2336 2017^ 158 166 616 940 Total 1734 703 10015 12452
Enrollment of Women and Minorities to Interventional trials Interventional, Hawaii Cancer Therapeutic 2016 % % Non-Therapeutic % Population^ Trial Accruals Trial Accruals Race White 2130 32.3 35 19.8 37 10.5 Black # 0 0.0 1 0.3 Native Hawaiian/ 994 15.1 30 16.9 254 71.8 Pacific Islander Asian 2926 44.4 69 39.0 52.0 14.7 Chinese 377 5.7 4 2.3 8 2.3 Japanese 1583 24.0 39 22.0 33 9.3 Filipino 967 14.7 13 7.3 6 1.7 Other Asian or 2+ Asian NR 13 7.3 4 1.1 Am. Indian/Alaska # 0 0.0 1 0.3 Native Other 536 8.1 14 7.9 0 0.0 Two or more races 29 16.4 9 2.5 Total 177 100 354 100 Ethnicity Hispanic/Latino NR 5 3.0 2 1.7 Non-Hispanic/Latino NR 164 97.0 119 98.3 Unknown 8 233 Total (% for known 177 100 354 100 only) Gender Female 3354 50.0 96 54.2 310 88.1 Male 3350 50.0 81 45.8 42 11.9
Faculty and Administrative Leadership Recruitments UH Cancer Center had several faculty and administrative leadership recruitments between 10/1/2016 and 10/1/2017. These recruitments included the addition of an Associate Director for Administration to oversee
operations. This provides renewed balanced leadership for the Cancer Center wherein the Director is supported by the ADA overseeing operations and the Deputy Director/Chief Scientific Officer overseeing development of new scientific and educational programs. The clinical trials enterprise was strengthened with the hiring of an experienced manager and two breast cancer-focused academic clinicians. A junior faculty member in Epidemiology was also hired to start to address the dearth of young faculty in the Center due to the lack of recruitments for several years prior to 10/1/2016. Recruitments are listed below: 1. Cliff Martin, MBA – Associate Director for Administration (E/M) 2. Melissa Merritt, PhD – Assistant Researcher 3. Jessica Rhee, MD – Medical Director, Clinical Trials Office, Associate Researcher/Professor 4. Jami Fukui, MD – Assistant Researcher/Professor 5. Kate Bryant-Greenwood, JD – Manager, Clinical Trials Office
UH Cancer Center to have balanced operating budget in FY2018 The UH Cancer Center will have a slightly positive operating margin of $400,000 in FY2018. This marks an elimination of the operating deficit that in FY2016 was over $7 million. This is due to many factors including: 1. Governor’s allocation of $2.4 million for FY2017 and FY2018. This was provided because of the defunding of the Cancer Center by the legislature over the past decade of $5 million per year and the legislature’s denial of the request during the past legislative session to restore that funding. 2. Restriction of maintenance and reserve fund for major building expenses at $6 million. 3. Reduction in expenses within the Cancer Center through prospective budgeting enhanced budgetary oversight and improved efficiencies of greater than $0.5 million per year. 4. Distribution from UH Mānoa of $2.1 million to partially correct the deficit in the UH Cancer Center “G” (general) funds allocation for support of permanent faculty and staff positions, bringing support for these positions from approximately 30% to just under 80%. This brings the Cancer Center closer to the level of UH Mānoa support provided to other organized research units. We very much appreciate the current UH Mānoa leadership’s commitment to correct the previous, long-standing inequities in G fund allocations. The surplus operating margin funds, along with reserve funds, will be utilized to support ongoing recruitments anticipated during FY2018.
The decline in cigarette tax disbursements has resulted in a reduction in legislative funding of the Cancer Center by approximately $5 million per year compared to 2009. The annual disbursement is now less than the combined building-related expenditures for bond payments, facilities-related costs, maintenance and utilities.
Future Opportunities With stable leadership and UH Mānoa support, the Cancer Center has a bright future to advance the understanding of cancer biology and cancer incidence particularly with respect to Hawai‘i’s unique cultural and ethnic diversity. UH Cancer Center research activities will continue to provide significant economic impact for the Island of O‘ahu locally and impact scientific discovery nationally.
Retention of NCI designation Retention of NCI designation is critical to support the research efforts, retain current faculty, recruit new faculty and support the Cancer Center’s mission to reduce the burden of cancer for the people of Hawai‘i. The NCI will send a site visit team to the Cancer Center January 31, 2018. A decision regarding funding for the Cancer Center Support Grant will be available by June 2018.
Clinical Trials Initiatives Over the next year, the Cancer Center will be launching a public education campaign about the benefits of clinical trials for cancer patients. Branding for this campaign was developed in conjunction with the School of Art Graphic Design Center. In addition, expansion of clinical trials to neighbor islands and development of an Early Phase Clinical Trials program will be pursued if funding can be secured.
Build out of UH Cancer Center Annex Draft plans have been developed with the assistance of the School of Architecture Community Design Center for the possible build-out of 36,000 sq. ft. of shell space adjacent to the UH Cancer Center. Proposals have included creation of an Early Phase Clinical Trials (“Phase I”) unit, a biotech incubator and additional laboratory space for new faculty recruitments. Plans will be dependent on securing appropriate funding through philanthropy, legislative capital improvement requests, and/or industry and healthcare partners.
Institute for Ethnic Diversity and Cancer Health Disparities UH Cancer Center faculty are nationally recognized for excellence in research focused on ethnic diversity and cancer. UH Cancer Center has the opportunity to expand this research and solidify a position as the national leader in this area. Efforts are underway to secure philanthropic support for creation of an Institute with resources to support new initiatives and additional faculty.
Faculty Recruitment Faculty recruitments are underway for Cancer Epidemiology, Cancer Prevention and Cancer Biology. These recruitments will focus on researchers who will be complementary to current UH Cancer Center faculty but will also expand the portfolio of research, be engaged in the educational missions of the University, and be highly collaborative across UH Departments, Schools and Colleges. Areas of focus for ongoing recruitments include microbiome and health, cancer imaging, cancer prevention and cancer immunology.
APPENDIX 1
Selected FY2017 publications by UH Cancer Center Faculty. Cancer Center members names are bolded. Intra = Intra-programmatic collaboration Inter = Inter-programmatic collaboration Insti = Inter-Institutional collaboration
Cancer Biology
Belton A, Xian L, Huso T, Koo M, Luo LZ, Turkson J, Page BD, Gunning PT, Liu G, Huso DL, Resar LM. STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway. Leuk Lymphoma. 2016;57(11):2681-4. PubMed PMID: 26952843; PMCID: PMC5580963. INSTI
Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature. 2017;546(7659):549-53. PubMed PMID: 28614305; PMCID: PMC5581194. INTRA
Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, Carbone M. Germline BAP1 mutations induce a Warburg effect. Cell Death Differ. 2017. PubMed PMID: 28665402. INTRA INSTI
Carbone M, Shimizu D, Napolitano A, Tanji M, Pass HI, Yang H, Pastorino S. Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma. Oncotarget. 2016;7(37):59314-21. PubMed PMID: 27447750; PMCID: PMC5312314. INTRA INSTI
Chen WL, Wang YY, Zhao A, Xia L, Xie G, Su M, Zhao L, Liu J, Qu C, Wei R, Rajani C, Ni Y, Cheng Z, Chen Z, Chen SJ, Jia W. Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential. Cancer Cell. 2016;30(5):779-91. PubMed PMID: 27746145; PMCID: PMC5496656. INSTI Goodison S, Ogawa O, Matsui Y, Kobayashi T, Miyake M, Ohnishi S, Fujimoto K, Dai Y, Shimizu Y, Tsukikawa K, Furuya H, Rosser CJ. A multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort. J Transl Med. 2016;14(1):287. PubMed PMID: 27717367; PMCID: PMC5055716. INTRA INSTI Han B, Shen Y, Zhang P, Jayabal P, Che R, Zhang J, Yu H, Fei P. Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression. Oncotarget. 2017;8(14):22490-500. PubMed PMID: 28157704; PMCID: PMC5410239. INTER INSTI Hilliard TS, Miklossy G, Chock C, Yue P, Williams P, Turkson J. 15alpha-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models. Mol Cancer Ther. 2017;16(4):601-13. PubMed PMID: 28069875; PMCID: PMC5380601. INTRA Mao W, Zhang X, Guo Z, Gao Z, Pass HI, Yang H, Carbone M. Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China. JAMA Oncol. 2017;3(4):562-4. PubMed PMID: 27918607; PMCID: PMC5569880. INTRA INSTI Naderi A. C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer. Oncotarget. 2017. PubMed PMID: 28571002. Norton RL, Fredericks GJ, Huang Z, Fay JD, Hoffmann FW, Hoffmann PR. Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcgammaR-mediated
phagocytosis. J Leukoc Biol. 2017;101(2):439-48. PubMed PMID: 27601625; PMCID: PMC5235904. INSTI Pellegrini L, Xue J, Larson D, Pastorino S, Jube S, Forest KH, Saad-Jube ZS, Napolitano A, Pagano I, Negi VS, Bianchi ME, Morris P, Pass HI, Gaudino G, Carbone M, Yang H. HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma. Oncotarget. 2017;8(14):22649-61. PubMed PMID: 28186988; PMCID: PMC5410252. INTRA INTER INSTI Peres R, Furuya H, Pagano I, Shimizu Y, Hokutan K, Rosser CJ. Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation. Oncotarget. 2016;7(28):43109-23. PubMed PMID: 27317771; PMCID: PMC5190012. INTRA INTER
Sulzmaier FJ, Young-Robbins S, Jiang P, Geerts D, Prechtl AM, Matter ML, Kesari S, Ramos JW. RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics. Oncotarget. 2016;7(48):79869-84. PubMed PMID: 27829215; PMCID: PMC5346757. INTRA INSTI Urquidi V, Netherton M, Gomes-Giacoia E, Serie DJ, Eckel-Passow J, Rosser CJ, Goodison S. A microRNA biomarker panel for the non-invasive detection of bladder cancer. Oncotarget. 2016;7(52):86290-9. PubMed PMID: 27863434; PMCID: PMC5349914. INSTI Zhao L, Wong LL, Shi X, Ji J. Should hepatic dysplastic nodules and regenerative nodules be regarded as premalignant lesions and treated? Hepatology. 2016;64(4):1370. PubMed PMID: 26754160. INTRA
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Markers Affecting CYP2A6 Activity and Lung Cancer Risk. Cancer research. 2016;76(19):5768-76. PubMed PMID: 27488534; PMCID: PMC5050097. INTRA INSTI Poirion OB, Zhu X, Ching T, Garmire L. Single-Cell Transcriptomics Bioinformatics and Computational Challenges. Front Genet. 2016;7:163. PubMed PMID: 27708664; PMCID: PMC5030210. Sargent JD, Gabrielli J, Budney A, Soneji S, Wills TA. Adolescent smoking experimentation as a predictor of daily cigarette smoking. Drug Alcohol Depend. 2017;175:55-9. PubMed PMID: 28391086; PMCID: PMC5443410. Soneji S, Barrington-Trimis JL, Wills TA, Leventhal AM, Unger JB, Gibson LA, Yang J, Primack BA, Andrews JA, Miech RA, Spindle TR, Dick DM, Eissenberg T, Hornik RC, Dang R, Sargent JD. Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults: A Systematic Review and Meta-analysis. JAMA Pediatr. 2017;171(8):788-97. PubMed PMID: 28654986. INSTI Wang H, Schmit SL, Haiman CA, Keku TO, Kato I, Palmer JR, van den Berg D, Wilkens LR, Burnett T, Conti DV, Schumacher FR, Signorello LB, Blot WJ, Zanetti KA, Harris C, Pande M, Berndt SI, Newcomb PA, West DW, Haile R, Stram DO, Figueiredo JC, Hispanic Colorectal Cancer S, Le Marchand L. Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. International journal of cancer. 2017;140(12):2728-33. PubMed PMID: 28295283; PMCID: PMC5505639. INTRA INSTI Wills TA, Sargent JD. Commentary: Do E-cigarettes reduce smoking? Prev Med. 2017;100:285- 6. PubMed PMID: 28583659. Wills TA. Commentary: E-Cigarettes and Adolescents' Risk Status. Pediatrics. 2017;139(2). PubMed PMID: 28115538; PMCID: PMC5260160 Wills TA, Sargent JD, Gibbons FX, Pagano I, Schweitzer R. E-cigarette use is differentially related to smoking onset among lower risk adolescents. Tob Control. 2016;26(5):534-9. PubMed PMID: 27543564; PMCID: PMC5537057. INTRA INSTI
APPENDIX 2
Feedback from community participants, Moonshot Summit, December 2016.
Moonshot Summit Feedback Report Putting the patient at the center of access and care: 1. The biggest concerns for patients include: chances of overcoming/surviving cancer, impact on patients and ‘loved ones' lives, financial barriers, what treatments are available, how to continue working/job stability, fear of treatment side effects, and what happens if treatments do not work. 2. Survivors & caregivers need a support system for long-term mental, physical, spiritual well-being, and financial recovery. 3. Providers need to work together to provide patient-centered care. 4. Other patients are advocates and can establish a "go to team" to support newly diagnosed patients. 5. Community support for cancer patients in support of challenges such as transportation, homecare. For example, recruit churches/schools, educate community partners, engage politicians in discussions to advocate for cancer research, get the news/media involved, provide cancer prevention education in schools.
Disparities in Cancer care: 1. Have a national health service to support access to cancer diagnosis and care. 2. For non-English speaking patients provide information about clinical trials in the patients’ native language, increase medical translators, and train community health outreach workers who are culturally part of the community to work with the medical staff. 3. Recruit and hire local physicians to return to their home community. 4. Create one-stop shops such as cancer resource centers to provide cancer resources and information. 5. Work with community organizations and clubs to provide assistance to cancer patients. For example, work with seniors, medical school and Native Hawaiian health organizations for needs such as transportation for medical care, translations, & navigation.
Supporting preventative health behaviors: 1. Some key barriers to the adoption of successful prevention strategies include the need to determine cost- effective screenings, access to care (many people do not have a primary care physician), education, and lack of insurance. 2. Some of the biggest drivers for behavior change are having culturally appropriate navigators, peer-to-peer help and policy changes. 3. The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening, detection and diagnosis. 4. Strategies for early detection and diagnosis include developing a health profile and physician recommendations. 5. Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings, social media, genetic counselors and face-to-face interactions.
Strategies for integrating advances in Cancer treatment into community care: 1. Encourage use by physicians of Physicians Data Query. 2. Involvement of Hawaii Cancer Consortium members (local hospitals and medical school/research center); to facilitate knowledge sharing and have researchers present at tumor boards. 3. Utilize websites, list servers to disseminate information including information about cancer and clinical trials 4. Move medical/research expertise from cancer centers to clinics/community: get researchers out in the field, teach medical students about clinical trials, advocate for prevention and screening such as Fecal Occult Blood test, HPV vaccine, motivate community to seek early detection, advertise cancer seminars in the news. Also have researchers talk about specialties, develop a local cancer hotline, and invest more in prevention through the Public Health Model with additional funding. 5. Develop training for non-oncology physicians in cancer care in isolated areas, utilize telemedicine as an educational tool.
Recruiting and retaining participants in clinical research:
1. When newly diagnosed, provide patients with credible information regarding clinical trials including investigational nature, indication for treatment, screening for eligibility, randomization, risks, side effects, costs, etc. 2. Conversation regarding clinical trials should be started by patient's physician because of existing trust relationship. 3. Connect patient with support groups of individuals with similar diagnoses. 4. Need a boost in investigator and clinician interactions regarding clinical trials for cross education. 5. Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research.
Act 38 and Act 39 Session Laws of Hawai‘i 2017
BOR Research & Innovation Committee Meeting November 1, 2017
Signing Ceremony June 19, 2017
2 Overview
• One of UH’s strategic directions is to grow the portfolio of sponsored research done at the University, and to promote innovation and workforce diversification in the state’s economy. One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer, which is designed to strengthen economies by getting new ideas, inventions and processes developed in universities to the private sector.
• Technology transfer and commercialization legislation was introduced in the 2015, 2016 and 2017 legislative sessions; successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017.
• Act 38 – Transfers responsibility to manage ethical issues arising in the context of technology transfer activities – such as financial conflicts of interests, or use of public resources--from the State Ethics Commission to the University of Hawai‘i.
• Act 39 – Establishes the innovation and commercialization initiative program under the direction of the Vice President for Research and Innovation; authorizes the University to engage in a range of technology transfer activities; and creates a special fund to implement the program.
3 Sunset and Reporting
• Act 38 is effective upon approval [June 19, 2017] and repealed on June 30, 2022. UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities.
• Act 39 is effective on July 1, 2017, and repealed on June 30, 2021. UH must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies.
4 Act 38 Highlights
• Act 38 transfers responsibility for compliance of technology transfer activities with ethics from State Ethics Commission to the University; Act 38 is not an “exemption” from any ethics oversight at all.
• Responsibility is transferred as to “activities” not “employees”, per Attorney General’s interpretation of the scope of Article XIV of the State Constitution, Code of Ethics.
5 Act 38 Highlights (cont.)
Typical types of conflict that might arise in the Technology Transfer context— the “wearing two hats” and “dual use” problems:
• Conflicts of Financial Interests by individual who is both a UH researcher and the start-up entrepreneur/key employee of an entity that licenses UH patent based on individual’s research.
• Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen.
• Conflicts of Public vs. Private benefits simultaneously resulting from use of University facilities or funds.
6 Act 38 Highlights (cont.)
Principles to Manage Conflicts:
• Insulate Investment Decisions/Decision makers from Operational Decisions/Decision makers.
• Justify each type of decision by independent “due diligence” appropriate to that type, e.g., investment committees recommend investments; research committee recommends direction of research.
• Recuse conflicted individuals from negotiating, influencing, or decision making.
“Each hat on its own head”
7 Notable Powers under Act 39
Act 39 allows the University to:
• Contribute equity, loan funds, or participate directly or indirectly to finance concepts or proposals that are likely to lead to viable business using university research.
• Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes.
• Provide instruction, training, and marketing assistance to support and promote projects in which UH invests.
8 Example of Using Act 39
• Incorporating UH Ventures, LLC, a Hawai‘i limited liability company, and forming single purpose subsidiaries thereunder.
Benefits:
Managing Conflicts of Interest “Each hat on own head, - - each head on own corporate body.”
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9 Business Registration
10
UH Ventures, LLC Functional Organizational Chart
11
Office of the Vice President for Research and Innovation Organizational Chart
12
Life Cycle of Proposals & Awards
BOR Research & Innovation Committee Meeting November 1, 2017 Proposal Submission
Funding PI writes Unit staff ORS reviews Submit to opportunity proposal & enters into proposal and sponsor (May prepares myGRANT budget take 9 to 12 budget (one and routes for months for month of approvals decision) effort)
2 Award/Account Setup
Award ORS review: ORS creates ORS creates Unit notified received; grants should award record account in account is uncommon to be relatively in myGRANT KFS active receive a quick; check from contracts take sponsor longer based on negotiation issues
3 Cost Reimbursement
Incur Costs in Project Account
Unit buys KFS UH Cash is KFS supplies: calculates ORS bills reduced by creates $1 F&A costs: sponsor for $1.40 A/R for $1 x 40% = $1.40 $1.40 40 cents
40 cents deposited into OH income account
4 Cost Reimbursement – Cont’d
Get Reimbursed
ORS A/R in KFS UH Cash is receives is reduced restored by check, wire by $1.40 $1.40 or EFT for $1.40 from sponsor
5 Award Closeout
• Sponsor withholds final payment until final technical report, inventory report, invention report and financial report are submitted
• Federal regulations provide for 90 days after project termination to complete this process
• Final payments are posted to accounting system like any other payment, but account is marked closed
6