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Zika Puzzle in Brazil: Peculiar Conditions of Viral Introduction and Dissemination - a Review
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 112(5): 319-327, May 2017 319 Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review Cristina Possas1/+, Patricia Brasil2, Mauro CA Marzochi3, Amilcar Tanuri4, Reinaldo M Martins1, Ernesto TA Marques5,6, Myrna C Bonaldo7, Antonio GP Ferreira8, Ricardo Lourenço-de-Oliveira9, Rita Maria R Nogueira10, Patricia C Sequeira10, Keyla BF Marzochi3, Akira Homma1 1Fundação Oswaldo Cruz-Fiocruz, Bio-Manguinhos, Assessoria Científica Sênior, Rio de Janeiro, RJ, Brasil 2Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Rio de Janeiro, RJ, Brasil 3Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Rio de Janeiro, RJ, Brasil 4Universidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de Genética, Rio de Janeiro, RJ, Brasil 5Fundação Oswaldo Cruz-Fiocruz, Centro de Pesquisas Aggeu Magalhães, Departamento de Virologia, Recife, PE, Brasil 6University of Pittsburgh, Center for Vaccine Research, Pittsburgh, PA, United States 7Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular de Flavivírus, Rio de Janeiro, RJ, Brasil 8Fundação Oswaldo Cruz-Fiocruz, Bio-Manguinhos, Departamento de Reativos para Diagnóstico, Rio de Janeiro, RJ, Brasil 9Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Mosquitos Transmissores de Hematozoários, Rio de Janeiro, RJ, Brasil 10Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Flavivírus, Rio de Janeiro, RJ, Brasil This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poor- est northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. -
Guia Do Evento Conference Guidebook
GUIA DO EVENTO CONFERENCE GUIDEBOOK MUSEU DO AMANHÃ Rio de Janeiro 7 a 9 de maio, 2019 Baixe o app EVENTMOBI pela loja de aplicativos do seu celular e fique por dentro de tudo sobre o Simpósio. Use o código: BIOFIOCRUZ Download the EVENTMOBI app from your mobile app store and keep updated about the Symposium.Use the code: BIOFIOCRUZ VI International Symposium on Immunobiologicals VII Seminário Anual Científico e Tecnológico 1 Bio-Manguinhos/Fiocruz VI International Symposium on Immunobiologicals 2 VII Seminário Anual Científico e Tecnológico Bio-Manguinhos/Fiocruz IV INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICALS & VII SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS IV International Symposium on Immunobiologicals & VI Seminário Anual Científico e Tecnológico de Bio-Manguinhos (RJ, 7-9 de maio de 2019) Rio de Janeiro Instituto de Tecnologia em Imunobiológicos 2019 TODOS OS DIREITOS RESERVADOS / ALL RIGHTS RESERVED Assessoria de Comunicação de Bio-Manguinhos/Fiocruz Edição conteúdo institucional: Paulo Schueler, Talita Wodtke e Renata Ribeiro Conteúdo institucional: Paulo Schueler, Danielle Guedes, Talita Wodtke e Rodrigo Perreira Projeto gráfico e diagramação: Danielle Guedes Administrativo: Alessandra Lopes e Carla Duarte Revisão de conteúdo cientifico: Cristina Possas Diagramação conteúdo científico: Gisele Miranda Imagens: Banco de imagens Bio-Manguinhos (Bernardo Portella) / Imagens domínio público. Tiragem: 800 exemplares Versão digital disponível no Arca (www.arca.fiocruz.br) Bio-Manguinhos/Fiocruz Av. Brasil, 4.365, Manguinhos, Cep: 21040-360, Rio de Janeiro, RJ Phone: +55 (21) 3882.9393 www.bio.fiocruz.br / facebook.com/BioFiocruz Ficha catalográfica elaborada pela Gestão de Documentos - GC Bio-Manguinhos / FIOCRUZ - RJ I61 International Symposium on Immunobiological (4. -
Yellow Fever Outbreak in Brazil: the Puzzle of Rapid Viral Spread and Challenges for Immunisation
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Repositório Institucional da Universidade de Brasília REVIEW Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 113(10): e180278, 2018 1|12 Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunisation Cristina Possas1/+, Ricardo Lourenço-de-Oliveira2/+, Pedro Luiz Tauil3, Francisco de Paula Pinheiro1, Alcides Pissinatti4, Rivaldo Venâncio da Cunha5, Marcos Freire1, Reinaldo Menezes Martins1, Akira Homma1 1Fundação Oswaldo Cruz-Fiocruz, Bio-Manguinhos, Rio de Janeiro, RJ, Brasil 2Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil 3Universidade de Brasília, Faculdade de Medicina, Brasília, DF, Brasil 4Centro de Primatologia do Rio de Janeiro, Instituto Estadual do Ambiente, Guapimirim, RJ, Brasil 5Fundação Oswaldo Cruz-Fiocruz, Campo Grande, MS, Brasil We discuss the complex eco-social factors involved in the puzzle of the unexpected rapid viral spread in the ongoing Brazilian yellow fever (YF) outbreak, which has increased the reurbanisation risk of a disease without urban cases in Brazil since 1942. Indeed, this rapid spatial viral dissemination to the Southeast and South regions, now circulating in the Atlantic Forest fragments close to peri-urban areas of the main Brazilian megalopolises (São Paulo and Rio de Janeiro) has led to an exponential increase in the number of yellow fever cases. In less than 18 months, 1,833 confirmed cases and 578 deaths were recorded most of them reported in the Southeast region (99,9%). Large epizooties in monkeys and other non-human primates (NHPs) were communicated in the country with 732 YF virus (YFV) laboratory confirmed events only in the 2017/2018 monitoring period. -
ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors
STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors Celina Souza • Flavio Fontanelli • Ana Célia Castro Antônio Márcio Buainain • Solange Corder • Maria Beatriz Machado Bonacelli Ignacio Godinho Delgado • Alexandre de Ávila Gomide Raphael Amorim Machado • Ana Karine Pereira Arnaldo Provasi Lanzara • Anna Jaguaribe • Maria Antonieta Leopoldi Fátima Anastasia • Luciana Las Casas • Flavio Gaitán • Renato Raul Boschi STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES 1 National Institute of Science and Technology in Public Policies, Strategies and Development (INCT/PPED) Coordinator Renato Boschi (INCT/PPED) Vice coordinator Ana Célia Castro (PPED/IE, CBAE/UFRJ and INCT/PPED) Management Staff Ana Célia Castro (PPED/IE/UFRJ) Antônio Márcio Buainain (IE/UNICAMP) Estela M. S. Neves (PPED/IE/UFRJ) Georges Flexor (CPDA/UFRRJ) Ignacio Delgado (UFJF) Maria Antonieta Leopoldi (PPGCP/UFF and PPED/UFRJ) Maria Beatriz Bonacelli (IGE/UNICAMP) Renato Boschi (INCT/PPED) Sérgio Pereira Leite (CPDA/UFRRJ) Advisory Board Cristina Possas (FIOCRUZ) Diego Sanchez-Ancochea (University of Oxford) Desenvolvimento em Debate Journal Editor: Flavio Gaitán (INCT/PPED and UNILA) Management support Ana Carolina Oliveira Secretary Sonia Lais da Rocha 2 STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors Celina Souza • Flavio Fontanelli • Ana Célia Castro Antônio Márcio Buainain • Solange Corder • Maria Beatriz Machado Bonacelli Ignacio Godinho Delgado • Alexandre de Ávila Gomide Raphael Amorim Machado • Ana Karine Pereira Arnaldo Provasi Lanzara • Anna Jaguaribe • Maria Antonieta Leopoldi Fátima Anastasia • Luciana Las Casas • Flavio Gaitán • Renato Raul Boschi Rio de Janeiro – Brazil 2020 3 Copyright © 2020 by the several contributors All rights reserved to the National Institute of Science and Technology in Public Policies, Strategies and Development- INCT/PPED. -
ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors
STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors Celina Souza • Flavio Fontanelli • Ana Célia Castro Antônio Márcio Buainain • Solange Corder • Maria Beatriz Machado Bonacelli Ignacio Godinho Delgado • Alexandre de Ávila Gomide Raphael Amorim Machado • Ana Karine Pereira Arnaldo Provasi Lanzara • Anna Jaguaribe • Maria Antonieta Leopoldi Fátima Anastasia • Luciana Las Casas • Flavio Gaitán • Renato Raul Boschi STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES 1 National Institute of Science and Technology in Public Policies, Strategies and Development (INCT/PPED) Coordinator Renato Boschi (INCT/PPED) Vice coordinator Ana Célia Castro (PPED/IE, CBAE/UFRJ and INCT/PPED) Management Staff Ana Célia Castro (PPED/IE/UFRJ) Antônio Márcio Buainain (IE/UNICAMP) Estela M. S. Neves (PPED/IE/UFRJ) Georges Flexor (CPDA/UFRRJ) Ignacio Delgado (UFJF) Maria Antonieta Leopoldi (PPGCP/UFF and PPED/UFRJ) Maria Beatriz Bonacelli (IGE/UNICAMP) Renato Boschi (INCT/PPED) Sérgio Pereira Leite (CPDA/UFRRJ) Advisory Board Cristina Possas (FIOCRUZ) Diego Sanchez-Ancochea (University of Oxford) Desenvolvimento em Debate Journal Editor: Flavio Gaitán (INCT/PPED and UNILA) Management support Ana Carolina Oliveira Secretary Sonia Lais da Rocha 2 STATE CAPACITIES and DEVELOPMENT in EMERGING COUNTRIES ANA CÉLIA CASTRO • RENATO RAUL BOSCHI Editors Celina Souza • Flavio Fontanelli • Ana Célia Castro Antônio Márcio Buainain • Solange Corder • Maria Beatriz Machado Bonacelli Ignacio Godinho Delgado • Alexandre de Ávila Gomide Raphael Amorim Machado • Ana Karine Pereira Arnaldo Provasi Lanzara • Anna Jaguaribe • Maria Antonieta Leopoldi Fátima Anastasia • Luciana Las Casas • Flavio Gaitán • Renato Raul Boschi Rio de Janeiro – Brazil 2020 3 Copyright © 2020 by the several contributors All rights reserved to the National Institute of Science and Technology in Public Policies, Strategies and Development- INCT/PPED. -
Vaccines for Neglected and Emerging Diseases in Brazil by 2030: the “Valley of Death” and Opportunities for RD&I in Vaccinology 4.0
ENSAIO ESSAY Vaccines for neglected and emerging diseases in Brazil by 2030: the “valley of death” and opportunities for RD&I in Vaccinology 4.0 Vacinas para doenças negligenciadas e emergentes no Brasil até 2030: o “vale da morte” e oportunidades para PD&I na Vacinologia 4.0 Vacunas en Brasil para enfermedades emergentes y olvidadas en 2030: el “valle de la muerte” y oportunidades para RD&I en Vacunología 4.0 Akira Homma 1 Marcos da Silva Freire 1 Cristina Possas 1 doi: 10.1590/0102-311X00128819 Abstract Correspondence C. Possas Instituto de Tecnologia em Imunobiológicos, Fundação We examine the implications of the very low competitiveness of the Brazilian Oswaldo Cruz. vaccine RD&I system, which precludes the development of all the important Av. Brasil 4365, Rio de Janeiro, RJ 21045-900, Brasil. vaccines required by the National Immunization Program (NIP), severely im- [email protected] pacting the healthcare of the population. In a country dramatically affected 1 by COVID-19 pandemic and by an exponential increase in emerging and ne- Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil. glected diseases, particularly the poor, these RD&I constraints for vaccines become crucial governance issues. Such constraints are aggravated by a global scenario of limited commercial interest from multinational companies in vac- cines for neglected and emerging diseases, which are falling into a “valley of death,” with only two vaccines produced in a pipeline of 240 vaccines. We stress that these constraints in the global pipeline are a window of opportu- nity for vaccine manufacturers in Brazil and other developing countries in the current paradigm transition towards Vaccinology 4.0. -
Vacinas E Vacinação No Brasil: Horizontes Para Os Próximos 20 Anos
VACINAS E VACINAÇÃO NO BRASIL: HORIZONTES PARA OS PRÓXIMOS 20 ANOS Akira Homma Cristina Possas José Carvalho de Noronha Paulo Gadelha ORGANIZADORES VACINAS E VACINAÇÃO NO BRASIL: HORIZONTES PARA DESAFIOSOS PRÓXIMOS 20 ANOS DO ACESSO A MEDICAMENTOS NO BRASIL VACINAS E VACINAÇÃO NO BRASIL: HORIZONTES PARA OS PRÓXIMOS 20 ANOS Fundação Oswaldo Cruz Presidente Nísia Trindade Lima Vice-presidente de Ambiente, Atenção e Promoção da Saúde Marco Antonio Carneiro Menezes Vice-presidente de Ensino, Informação e Comunicação VACINAS Cristiani Vieira Machado Vice-presidente de Gestão e Desenvolvimento Institucional Mario Santos Moreira Rodrigo Correa de Oliveira Vice-presidente de Pesquisa e Coleções Cientícas Rodrigo Correa de Oliveira E VACINAÇÃO Vice-presidente de Produção e Inovação em Saúde Marco Aurelio Krieger Instituto de Comunicação e Informação NO BRASIL: Diretor HORIZONTES PARA Rodrigo Murtinho Vice-diretor de Pesquisa, Ensino e Desenvolvimento Tecnológico OS PRÓXIMOS 20 ANOS Christovam Barcellos Vice-diretor de Informação e Comunicação Akira Homma Tânia Cristina Pereira dos Santos Cristina Possas Vice-diretor de Desenvolvimento Institucional arv Jacques Sochaczewski José C alho de Noronha Paulo Gadelha Estratégia Fiocruz para Agenda 2030 ORGANIZADORES Coordenador Paulo Gadelha Iniciativa Brasil Saúde Amanhã Coordenador-executivo José Carvalho de Noronha Fundação Oswaldo Cruz Presidente Nísia Trindade Lima Vice-presidente de Ambiente, Atenção e Promoção da Saúde Marco Antonio Carneiro Menezes Vice-presidente de Ensino, Informação e Comunicação -
Brazilian Ministry of Health Health Surveillance Secretariat STD, AIDS and Viral Hepatitis Department
Brazilian Ministry of Health Health Surveillance Secretariat STD, AIDS and Viral Hepatitis Department Targets and Commitments made by Member‐States at the United Nations General Assembly Special Session on HIV/AIDS UNGASS – HIV/AIDS Brazilian Response 2008‐2009 Country Progress Report Brazil, March 2010 The Federative Republic of Brazil Ministry of Health Health Surveillance Secretariat STD, AIDS and Viral Hepatitis Department Technical Index of the Brazilian Progress Report: Institutional authorship of this document is attributed to the National STD and AIDS Commission ‐ CNAIDS General Coordination: Mariângela Batista Galvão Simão (Director of the STD, AIDS and Viral Hepatites Department); Eduardo Luiz Barbosa (Joint Director of the STD, AIDS and Viral Hepatites Department) Organization: Ângela Pires Pinto (STD, AIDS and Viral Hepatites Department) Report writer: Fernando Seffner (Consultant) Working group designated by CNAIDS for data gathering and producing this report: Mariângela Simão (Director of the STD, AIDS and Viral Hepatitis Department and Coordinator of the Working Group); Ana Maria de Oliveira (Federal Medical Council); Euclides Ayres Castilho São Paulo University); Felipe Krause Dornelles (Ministry of Foreign Affairs); Jacqueline Côrtes (Joint United Nations Programmme on HIV/AIDS ‐ UNAIDS); Jaime Marcelo Pereira (AIDS NGO Forum – Southeast Region); Jair Brandão Filho (UNGASS Forum/Gestos ‐ Seropositivity, Communication and Gender); José Carlos Veloso (UNGASS Forum/GAPA/SP); Maria Clara Gianna (STD/AIDS Actions Management -
Yellow Fever Outbreak in Brazil: the Puzzle of Rapid Viral Spread and Challenges for Immunisation
REVIEW Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 113(10): e180278, 2018 1|12 Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunisation Cristina Possas1/+, Ricardo Lourenço-de-Oliveira2/+, Pedro Luiz Tauil3, Francisco de Paula Pinheiro1, Alcides Pissinatti4, Rivaldo Venâncio da Cunha5, Marcos Freire1, Reinaldo Menezes Martins1, Akira Homma1 1Fundação Oswaldo Cruz-Fiocruz, Bio-Manguinhos, Rio de Janeiro, RJ, Brasil 2Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil 3Universidade de Brasília, Faculdade de Medicina, Brasília, DF, Brasil 4Centro de Primatologia do Rio de Janeiro, Instituto Estadual do Ambiente, Guapimirim, RJ, Brasil 5Fundação Oswaldo Cruz-Fiocruz, Campo Grande, MS, Brasil We discuss the complex eco-social factors involved in the puzzle of the unexpected rapid viral spread in the ongoing Brazilian yellow fever (YF) outbreak, which has increased the reurbanisation risk of a disease without urban cases in Brazil since 1942. Indeed, this rapid spatial viral dissemination to the Southeast and South regions, now circulating in the Atlantic Forest fragments close to peri-urban areas of the main Brazilian megalopolises (São Paulo and Rio de Janeiro) has led to an exponential increase in the number of yellow fever cases. In less than 18 months, 1,833 confirmed cases and 578 deaths were recorded most of them reported in the Southeast region (99,9%). Large epizooties in monkeys and other non-human primates (NHPs) were communicated in the country with 732 YF virus (YFV) laboratory confirmed events only in the 2017/2018 monitoring period. We also discuss the peculiarities and similarities of the current outbreak when compared with previous great epidemics, examining several hypotheses to explain the recent unexpected acceleration of epizootic waves in the sylvatic cycle of the YFV together with the role of human, NHPs and mosquito mobility with respect to viral spread. -
Zika: What We Do and Do Not Know Based on the Experiences of Brazil
Epidemiology and Health Volume: 38, Article ID: e2016023, 7 pages Epidemiology and Health http://dx.doi.org/10.4178/epih.e2016023 REVIEW Open Access Zika: what we do and do not know based on the experiences of Brazil Cristina Possas Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil OBJECTIVES: Zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through Latin America, the Caribbean, the US and Asia, after causing a large outbreak in the Northeast region of Brazil in 2015. There is ample evidence to support that Zika virus is associated with neurological complications such as microcephaly. The review aims to provide an overview on the complex is- sues involved in the emergence of Zika virus’s neurological disorders and to discuss possible explanations of Zika virus introduction and dissemination in Brazil. We also suggest national and global strategies to adequate- ly respond to the Zika virus emergence. METHODS: We provide an analytical evaluation of the main issues related to the Zika outbreak in Brazil, based on available scientific literature, including government documents, and on epidemiological information from national surveillance databases. RESULTS: The studies on the clinical manifestations of the Zika virus infection coupled with the epidemiolog- ical surveillance information in Brazil have provided significant evidence that the Zika virus is associated with neurological disorders such as microcephaly and Guillain-Barré syndrome. Based on phylogenetic and molec- ular analysis, the hypothesis regarding the introduction of Zika virus in the country is that it took place follow- ing international events in 2013 and 2014, when many foreign visitors could have brought Zika virus into Brazil. -
1 DISCLAIMER This Paper Was Submitted to the Memórias Do
DISCLAIMER This paper was submitted to the Memórias do Instituto Oswaldo Cruz on 6 June 2018 and was posted to the Fast Track site on 7 June 2018. The information herein is available for unrestricted use, distribution and reproduction provided that the original work is properly cited as indicated by the Creative Commons Attribution licence (CC BY). RECOMMENDED CITATION Possas C, Lourenço-de-Oliveira R, Tauil PL, Pinheiro FP, Pissinatti A, da Cunha RV, et al. Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization [Submitted]. Mem Inst Oswaldo Cruz E-pub: 7 Jun 2018. doi: 10.1590/0074-02760180278. Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization Cristina Possas1/+, Ricardo Lourenço de Oliveira2/+, Pedro Luiz Tauil3, Francisco de Paula Pinheiro1, Alcides Pissinatti4, Rivaldo Venâncio da Cunha5 , Marcos Freire1, Reinaldo Menezes Martins1, Akira Homma1 + corresponding authors 1 Oswaldo Cruz Foundation, Bio-Manguinhos, Rio de Janeiro, Brazil 2 Oswaldo Cruz Foundation, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil 3 University of Brasilia, Medical School, Brasília, DF, Brazil 4. Center of Primatology of Rio de Janeiro, State Environment Institute, Rio de Janeiro, Brazil 5 Oswaldo Cruz Foundation, Campo Grande, Brazil Abstract We discuss the complex eco-social factors involved in the puzzle of the unexpected rapid viral spread in the ongoing Brazilian yellow fever outbreak, which has increased the reurbanization risk of a disease without urban cases in the Americas since 1942. Indeed, this rapid spatial viral dissemination to the 1 Southeast and South regions, now circulating in the Atlantic Forest fragments close to peri-urban areas of the main Brazilian megalopolises (São Paulo and Rio de Janeiro) has led to an exponential increase in the number of yellow fever cases. -
Vaccine Vaccine Research, Development, and Innovation in Brazil
Vaccine 31S (2013) B54–B60 Contents lists available at SciVerse ScienceDirect Vaccine j ournal homepage: www.elsevier.com/locate/vaccine Review Vaccine research, development, and innovation in Brazil: A translational science perspective a,∗ b c d,f c Akira Homma , Amilcar Tanuri , Alberto J.S. Duarte , Ernesto Marques , Alexandre de Almeida , a e a Reinaldo Martins , Jarbas B. Silva-Junior , Cristina Possas a Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil b Federal University of Rio de Janeiro, Brazil c Medical School, University of São Paulo, Brazil d Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife, Brazil e Ministry of Health, National Secretariat of Health Surveillance, Brasília, Brazil f University of Pittsburgh, Center for Vaccine Research, Pittsburgh, United States a r t i c l e i n f o a b s t r a c t Keywords: This article examines the Brazilian innovation policy for vaccines and its impact on infectious diseases, Vaccines with emphasis on advances in translational science. The results indicate significant progress, with a Innovation rapid increase over the past two decades in the number of vaccine research groups, indicating scientific Translational sciences excellence. Advances and gaps in technological development and in public–private partnership initiatives Brazilian immunization program were also identified. We stress the crucial role of partnerships, technology transfer, and targeted policies that could accelerate Brazil’s participation in global vaccine research and development. We propose that new strategies should be urgently conceived to strengthen the links between the scientific and technological policies, the National Health System, and the National Immunizations Program in Brazil to provide access to low-cost vaccines to address major public health challenges.