St. Catherine of Siena (1347-1380 AD), one of the earliest historic cases of altered gustatory perception in anorexia mirabilis Francesco M. Galassi1#, Nicole Bender1#*, Michael E. Habicht1, Emanuele Armocida2, Fabrizio Toscano3, David A. Menassa4, Matteo Cerri5 1 Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich 2 University of Parma, Parma, Italy. 3 University of Siena, Post-Graduate School of Public Health, Siena, Italy 4 Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, OX3 9DU, UK 5 Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy # Co-first authors * Correspondence to Dr Nicole Bender, email:
[email protected] Email adresses Francesco M. Galassi :
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[email protected] Abstract St. Catherine of Siena suffered from an extreme form of holy fasting, a condition classified as anorexia mirabilis (also known as inedia prodigiosa). Historical and medical scholarships alike have drawn a comparison between this primaeval type of anorexia with a relatively common form of eating disorder among young women in the modern world, anorexia nervosa. St. Catherine’s condition was characterized by a disgust for sweet taste, a condition also described in anorexia nervosa, and characterized by specific neurophysiological changes in the brain. St. Catherine’s 1 case may be considered one of the oldest veritable descriptions of altered gustation (dysgeusia).