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Gift Launches Yale Autoimmunity Center

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Gift Launches Yale Autoimmunity Center november/december 2019 volume 15, issue 3 Advancing Biomedical Science, Education, and Health Care Yale School of Medicine prepares to welcome its 19th dean Yale College alumna Nancy medicine and fellowship in clinical Brown has been chair of pharmacology at Vanderbilt, she joined the faculty there in 1992. medicine at Vanderbilt The path to leadership that Brown followed at Vanderbilt reflects Nancy J. Brown, MD, has been her passions for pursuing research appointed the next dean of Yale and nurturing the next generation School of Medicine (YSM), effec- of physician-scientists. She was chief tive February 1, 2020. of the Division of Clinical Pharma- Brown, who is in line to be the cology, which is part of both a basic 19th dean of the medical school science department (pharmacology) and first woman to hold the post, and a clinical department (medicine). joins Yale from Vanderbilt Uni- She served as associate dean for versity School of Medicine, where clinical and translational scientist she is Hugh J. Morgan Professor development, establishing the Elliot and chair of the Department of Newman Society to support the devel- Medicine. A 1981 alumna of Yale opment of physician-scientists, before College, where she majored in becoming chair of medicine in 2010. robert a. lisak molecular biophysics and biochem- She also co-founded the Vanderbilt Under her stewardship, Vander- Nancy Brown takes office as dean on February 1. istry, Brown earned her medical Master of Science in Clinical Investi- bilt’s Department of Medicine, Her early priorities include improving the work climate at the School of Medicine, exploring new degree at Harvard University. After gation program to train investigators which today has more than 900 opportunities to develop physician-scientists, and completing her residency in internal in patient-oriented research. faculty members and // Dean (page 11) supporting Yale’s strategic plan for science. Gift launches Yale autoimmunity center A new pathology chair is named, will The Colton Center’s mission arrive in March is to identify and nurture Chen Liu, MD, PhD, research leading to cures will become chair of the Department What do type 1 diabetes, rheumatoid of Pathology at Yale arthritis, systemic lupus erythemato- School of Medicine sus (SLE), multiple sclerosis, inflam- and chief of Pathol- matory bowel disease, and celiac ogy at Yale New Ha- disease have in common? As different ven Hospital, effective as they are in clinical presentation, Chen Liu March 1, 2020. they share an important characteris- Liu comes to Yale from Rutgers tic. Each is an autoimmune disease. University, where since 2015 he has More than 80 different autoim- been professor and chair of pathology, mune diseases occur as a result of immunology, and laboratory medicine the immune system attacking the at New Jersey Medical School and body’s own organs, tissues, and cells, Robert Wood Johnson (RWJ) Medi- causing inflammation and cell death. cal School and chair of the Center for Some 23.5 million individuals are robert a. lisak Dermatology at RWJ Medical School. affected in the U.S., and the diseases’ Joseph Craft is the inaugural director of the Colton Center for Autoimmunity at Yale, established through He is also chief of service at University a gift from philanthropists Judith and Stewart Colton. Diseases that affect some 23.5 million Americans are prevalence continues to rise. Scien- the focus of the center, which will nurture innovative research with a goal of finding safe, effective treat- Hospital in Newark and RWJ Univer- tists lack a clear understanding of ments and preventives. sity Hospital in New Brunswick and the causes of autoimmune disorders, chief of the Division of Oncological Pa- limiting their ability to develop safe, philanthropists Judith and Stewart Paul B. Beeson Professor of Medicine thology at the Rutgers Cancer Institute effective treatments and preventives. Colton have donated a major gift and professor of immunobiology, of New Jersey. With a keen interest in autoim- to establish the Colton Center for the center will focus on nurturing After obtaining his medical mune disease and a shared vi- Autoimmunity at Yale. Under the the development of new diagnostics, degree at Tong Liao Medical College sion of finding new therapies, direction of Joseph E. Craft, MD, therapies, // Autoimmune (page 10) at Inner Mongolia // Chair (page 5) Non-Profit Org. INSIDE THIS ISSUE 1 Church St., Suite 300, New Haven, CT 06510-3330 U. S. Postage www.medicineatyale.org 2 Lifelines PAID Karen Santucci, MD, believes emergency New Haven, CT department care can change the trajectories Permit No. 526 of young lives, and has made it her calling. 3 Putting genomics to novel uses The medical school and Yale New Haven Health have launched Generations, an ambitious DNA sequencing project. 11 The value of palliative care Jennifer Kapo, MD, becomes the first holder of an endowed professorship that honors palliative care and her practice of it. FOLLOW & SHARE twitter.com/YaleMed facebook.com/YaleMed instagram.com/YaleMed lifelines University opens state-of-the-art science building Karen Santucci has been On October 29, a caring clinician at times when her patients may need the University her most. Hers is the first dedicated the face many see when they arrive at Yale New Haven new Yale Science Health pediatric emergency Building (YSB) departments in New Haven and Greenwich. She also has on the footprint been a leading administrator of the former at the School of Medicine and the health system. J.W. Gibbs Anna Marie Pyle Laboratory. YSB, which will serve as a cen- tral hub for interdisciplinary col- laboration on Science Hill, is de- signed to bring natural light into lab spaces, and contains common areas intended to bring researchers Karen Santucci together as they walk through the robert a. lisak building. Its approximately 550 occupants include members of the departments of molecular, cel- Care when a child has a sudden need lular, and developmental biology; and of molecular biophysics and A career of treating young Santucci always had an interest in of her success—and the emergency biochemistry. patients and seeing that pediatrics, but ultimately chose pediatric department’s achievements— to her col- It includes a cryo-electron emergency rooms run well emergency medicine because she knew leagues. “I work with absolute giants,” microscopy facility as well as life- that was the only way she could leave she says. “They’re amazing people, and I microscopy, chemical-synthesis, Karen Santucci, MD, professor of pediat- some of her work “at the office.” would do just about anything for them.” and insectary and aquatics cores; rics (emergency medicine) and of emer- “I knew I had to control when I had The same goes for her patients. Pedi- a quantitative biology center, and gency medicine, usually has two things in patient exposure because I get very atric emergency medicine presents its physics laboratories. her purse: dollar store items, and snacks. invested in them,” she says. “Having own special sets of challenges, she says, Both carry important significance to her trusted colleagues to whom I can pass due to how young incoming patients are “This building is completely work in the pediatric department at Yale the baton at the end of a shift was a way and, oftentimes, their fear of doctors. unique among modern science New Haven Children’s Hospital, where to have everything in the hospital, but The right knee of Santucci’s scrubs is buildings because of the breadth she performs several roles including have a family too.” often worn thin from the amount of time of scientific endeavor that it is section chief of emergency medicine and Santucci came to Yale in 1999. That she spends kneeling next to beds, com- designed to accommodate,” said interim section chief of pediatric oncology same year she helped design and launch a forting both patients and their families. Anna Marie Pyle, PhD, Sterling and hematology. She also is vice chair for pediatric emergency medicine fellowship But she also finds treating children to be Professor of Molecular, Cellular, clinical affairs in the Department of Pedi- program, which now receives more than a more hopeful endeavor than treating and Developmental Biology, and atrics at the School of Medicine. 100 applicants a year for two available some adults. chair of the YSB Building Com- The snacks she keeps with her are positions. And that was just the beginning “One of the beautiful things about pedi- mittee. “Most important, when for meetings or shifts in the emergency of her influence in the department. atric emergency medicine is that we’re the future inevitably comes, the department, to keep everyone energized. Santucci has been section chief of getting to these children early enough The dollar store items she uses as props pediatric emergency medicine since that we might actually be able to change labs inside YSB can be completely and prizes during her Friday rounds, which 2010, and until recently served as medical a trajectory,” she says. “There’s a very dif- dismantled to do new kinds of she calls TGIIFF—Team Gathering Innova- director of emergency pediatrics, before ferent illness set on the adult side.” science that we don’t even envi- tion, Information, Facts, and Fun. Providing transitioning to vice chair of clinical When she is not in the emergency sion today.” for her team and her patients is a corner- affairs. Two and a half years ago she was department, Santucci is running between “In 100 years, when people stone of Santucci’s professional career. also asked to start a pediatric emergency her offices, juggling her administra- look back to this moment, they Born near New York City, Santucci was medicine program at Greenwich Hos- tive roles.
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