DOCSLIB.ORG

I. the Motor Endplate and Presynaptic Mechanisms

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
I. the Motor Endplate and Presynaptic Mechanisms CONTENTS On David Nachmansohn's Relationship to Berlin H. Herken XV David Nachmansohn (1899-1983): a pioneer of neurochemistry Jean-Pierre Changeux 1 I. THE MOTOR ENDPLATE AND PRESYNAPTIC MECHANISMS Remodelling of neuromuscular junctions during repair of muscle fibres R. Couteaux, J.C. Mira 35 Intermittant, Calcium independent release of acetylcholine from motor nerve terminals S. Thesleff 47 Prostaglandins mediate the muscarinic inhibition of acetyl- choline release from Torpedo nerve terminals I. Pinchasi, M. Burstein, D.M. Michaelson 55 Molecular mechanisms underlying acetylcholine release M. Israel, N. Morel, S. Birman, B. Lesbats, R. Manaranche 77 Adenosine-5'-Triphosphate at the cholinergic synapse: a cotransmitter? H. Zimmermann, E.J.M. Grondal 91 XVIII Solubilization, affinity labelling and purification of the dihydropyridine receptor of the voltage-dependent calcium channel from rabbit skeletal muscle transverse tubule mem- branes M. Borsotto, J. Barhanin, J.-P. Galizzi, M. Fosset, M. Lazdunski Is ATP a general molecular constituent of cholinergic synaptic vesicles? W. Volknandt, H. Zimmermann 121 Single channel formation of cooperatively interacting units of the highly-purified Na-channel protein G. Boheim, W. Hanke, J. Barhanin, D. Pauron, M. Lazdunski 131 K -channels in rat ventricular cells show voltage-dependent outward rectification and non-linear voltage to current relation W. Schreibmayer, H. Hagauer, H.A. Tritthart, H. Schindler 145 A purification procedure of the tetrodotoxin binding compo- nent contained in the electroplaxes of Electrophorus electri- cus G. Dandrifosse, Ch. Grandfils, L. Bettendorff, E. Schoffe- niels, J. Bontemps 153 High-yield synthesis of a new Na-channel marker: (3H)ethylenediamine ditetrodotoxin or ED-diTTX Ch. Grandfils, L. Bettendorff, E. Schoffeniels, J. Bontemps, G. Dandrifosse 163 Insect olfactory cells: electrophysiological and biochemical studies K.E. Kaissling, U. Klein, J.J. de Kramer, T.A. Keil, S. Kanaujia, J. Hemberger 173 8 6 Effects of extracellular ATP on Rb influx in chick myotubes; indications of a cotransmitter role in neuro- muscular transmission J. Häggblad, H. Eriksson, E. Heilbronn 185 XIX II. THE ACETYLCHOLINE RECEPTOR: STRUCTURAL ASPECTS A monoclonal antibody specific for one of the two agonist binding sites at the acetylcholine receptor G. Fels, A. Maelicke, D. Schafer, J.P. Walrond, Th. Reese 197 The molecular biology of acetylcholine receptors A. Mauron, P. Nef, M. Ballivet 209 Antibodies to synthetic peptides as probes of nicotinic acetylcholine receptor structure T. Barkas , M. Juillerat 223 Regulation of the nicotinic acetylcholine receptor by phosphorylation E. Heilbronn, H. Eriksson, R. Salmonsson 237 Molecular interactions between the major proteins of the postsynaptic domain in Torpedo marmorata electromotor synapse J. Cartaud, C. Kordeli, H.O. Nghiem, J.-P. Changeux 251 The glycine receptor of rat spinal cord: progress in the investigation of a neuronal ion channel protein H. Betz , G. Grenningloh, B. Schmitt . ... 263 Antibodies to synthetic peptides as probes for the ct-subunit and for the cholinergic binding site of the acetylcholine receptor D. Neumann, J.M. Gershoni, M. Fridkin, S. Fuchs 273 Postsynaptic modulation of neuronal firing pattern by adenosine P. Schubert, K.S. Lee, W. Tetzlaff, G.W. Kreutzberg 283 Major proteins of the electric organ from Torpedo marmorata - possible associations with the postsynaptic membrane V. Witzemann, C.M. Boustead, J.H. Walker 293 XX Protein-blot analysis of the nicotinic acetylcholine receptor J.M. Gershoni, E. Hawrot, P.T. Wilson, T.L. Lentz 303 III. THE ACETYLCHOLINE RECEPTOR: FUNCTIONAL ASPECTS Acetylcholine receptor (from Electrophorus Electricus): A comparison of single-channel current recordings and chemical kinetic measurements G.P. Hess, H.-A. Kolb, P. Lauger, E. Schoffeniels, W. Schwarze, J.B. Udgaonkar, E.B.Pasquale 317 Photoaffinity labelling of receptor states with millisecond time resolution A. Fahr, L. Lauffer, F. Hucho 335 Binding of ["^h] acetylcholine to acetylcholine receptor from Torpedo californica under equilibrium conditions: stoichiometry and evidence for long-lived metastable states H.W. Chang, E. Bock, E. Neumann 351 The dimer of Torpedo acetylcholine receptor: Synchronized double channel E. Neumann, F. Spillecke, H. Schindler 369 Synchronization of electrically and chemically excitable ion channels H. Schindler, W. Schreibmayer 387 Effects of histrionicotoxi-n on the synaptic and conducting membranes of the electroplax E. Bartels 399 Thiamine triphosphate as specific operating substance in axonal conduction E. Schoffeniels, D.G. Margineanu 401 XXI Dose response curves at the neuromuscular junction R. Sterz, K. Peper 417 NBD-5-acylcholine is a fluorescent agonist of the membrane- bound acetylcholine receptor from Torpedo marmorata M. Covarrubias, A. Maelicke 429 Do signoid dose-response curves require the assumption of allostericity? H. Prinz, A. Maelicke 437 Foundations of the ion flux method J. Bernhardt, E. Neumann 445 Surface processes in ion transport and excitation M. Blank 457 Chemical kinetic investigations of the effects of cis and trans bis-Q on the acetylcholine receptor in Electrophorus electricus vesicles A.H. Delcour , G.P. Hess 465 Determination of thiamine and its phosphate esters by reversed-phase HPLC at femtomole levels. Application to bioelectrogenes is L. Bettendorff, Ch. Grandfils, E. Schoffeniels, J. Bontemps, D. Schmartz, G. Dandrifosse 479 IV. IMMUNOLOGY OF THE ACETYLCHOLINE RECEPTOR: MYASTHENIA GRAVIS AND SYNAPTIC PLASTICITY Regulation of the immune response to the acetylcholine receptor and of experimental myasthenia S. Fuchs, Miry C. Souroujon, S. Bogen 493 XXII Congenital and autoimmune deseases of the neuromuscular junction A. Vincent, P.J. Whiting, J. Newsom-Davis 505 Anti-idiotypic antibody to the acetylcholine and adenosine receptors B.F. Erlanger, W.L. Cleveland, N.H. Wassermann, B.L. Hill, A. S . Penn, H.H. Ku, R. Sarangarajan 523 Analysis of the prophylactic and therapeutic action of elec- trolectin in experimental autoimmune myasthenia gravis V.l. Teichberg, G. Levi 537 Regulation of acetylcholine receptors on muscle in vitro by central nervous system factors T.R. Podleski, I. Greenberg, D. Knaack, K. Neugebauer, M.M. Salpeter 551 Use and disuse and the control of acetylcholinesterase activity in fast and slow twitch muscle of rat W.-D. Dettbarn, D. Groswald, R.C. Gupta, K.E. Misulis ... 567 The expression of microtubule proteins during the development of the nervous system I. Ginzburg, U.Z. Littauer 589 V. ACETYLCHOLINESTERASE AND CHOLINE ACETYLTRANSFERASE Acetylcholinesterase of muscle and nerve W.R. Randall, Josephine Lai, E. A. Barnard 595 Expression of acetylcholinesterase in murine neural cells in vivo and in culture J. Massoulie, M. Vigny, M. Lazar 619 XXIII The involvement of phosphatidylinositol in the anchoring of hydrophobic forms of acetylcholinesterase to the plasma mem- brane A.H. Futerman, P.L. Barton, R.M. Fiorini, M.G. Low, W.R. Sherman, I. Silman 635 The hydrophobic domain of human erythrocyte acetylcholin- esterase contains nonamino acid components T.L. Rosenberry, R. Haas, W.L. Roberts, B.H. Kim 651 Cholinesterase: two surprising inhibitors I.B. Wilson 667 Correlation of assumed functions of acetylcholinesterase with its cellular and subcellular distribution M. Brzin 679 The mechanism of action of choline acetyltransferase H.G. Mautner 697 Acetylcholinesterase in regenerating skeletal muscles J. Sketelj , A. Blinc, M. Brzin 709 Distribution and regulation of acetylcholinesterase forms in chick myotubes: comparison with rat myotubes M. Vigny, F. Vallette 719 Acetylcholinesterase in mammalian skeletal muscle and sympa- thetic ganglion cells. Extra and intracellular hydrophilic and hydrophobic asymmetric forms P. Dreyfus, M. Verdiere, D. Goudou, L. Garcia, F. Rieger 729 Inhibition and photoaffinity labeling of acetylcholin- esterase by phencyclidine and triphenylmethylphosphonium J. Verdenhalven, F. Hucho 741 A comparative study of the ageing of DFP-inhibited serine hydrolases by means of ^Ip-^MR and mass spectrometry A.C.M. van der Drift 753 XXIV Lipid mechanism and acetylcholinesterase function K. Kaufmann 765 AUTHOR INDEX 779 SUBJECT INDEX 781 .
Load more

Recommended publications
  • Download This PDF File
    doi: http://dx.doi.org/10.5016/1806-8774.2009v11pT1 ARBS Annual Review of Biomedical Sciences Theme Topic on “Cell Receptors and Signaling” pdf freely available at http://arbs.biblioteca.unesp.br 2009;11:T1-T50 Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors Alexander G Karczmar* Research Service, Edward J. Hines VA Hospital and Department of Pharmacology, Loyola U. Medical Center, IL, USA Received: 23 October 2009; accepted 22 December 2009 Online on 21 February 2010 .Abstract Karczmar AG.. Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors. Annu Rev Biomed Sci 2009;11:T1-T50. This review of the studies of the muscarinic receptors, their synaptic activities and their functional and behavioral roles will begin with the history of the research of the autonomic and central nervous systems and their transmitters, the development of the notion of the receptor, and the tale of the significance of muscarine and other alkaloids as well as of organophosphorus (OP) anticholinesterases for these studies; we will then segue into the modern status of muscarinic receptors and of their functional and behavioral expression. © by São Paulo State University – ISSN 1806-8774 Keywords: muscarinic, cholinesterase, cholinergic, nicotinic, curare, atropine, behavior Table of Contents 1. Early Story of the Autonomic and Central Nervous System 2. The Early Story of Pharmacologically Active Alkaloids and of OP AntiChEs 3. From Gaskell’s and Langley’s Definition of Autonomic Nervous System to Loewi’s Demonstration of Peripheral Chemical, Cholinergic Transmission 4. Eccles’s Demonstration of Central Chemical, Cholinergic Transmission and Immediate Post-Ecclessian Studies of Central Nicotinic and Muscarinic Transmission 5.
    [Show full text]
  • Jean-Pierre G. Changeux
    EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F.
    [Show full text]
  • DAVID NACHMANSOHN March 17, 1899-November 2, 1983
    NATIONAL ACADEMY OF SCIENCES D A V I D N ACHMANSOHN 1899—1983 A Biographical Memoir by SEVERO OCHOA Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1989 NATIONAL ACADEMY OF SCIENCES WASHINGTON D.C. DAVID NACHMANSOHN March 17, 1899-November 2, 1983 BY SEVERO OCHOA AVID NACHMANSOHN'S scientific life path was strongly D influenced by his early studies on the biochemistry of muscle in Otto Meyerhof's laboratory. This experience led to an interest in the biochemistry of nerve activity, a field of study to which he would devote most of his scientific life. In so doing, he contributed—perhaps more than any other in- vestigator—to our understanding of the molecular basis of bioelectricity. David Nachmansohn was born in Jekaterinoslav, Russia (now Dnjetropetrowsk, USSR). His parents came from middle-class families among whom were many lawyers, phy- sicians, and other professionals. Before David and his two sisters reached school age, the family moved to Berlin where they had many relatives. Thus, David's background and edu- cation were essentially, if not exclusively, German. His college education was strongly humanistic, with Latin, Greek, liter- ature, and history as mainstays, some mathematics, and the rudiments of physics. Through his readings, perhaps pri- marily through his reading of the second part of Goethe's Faust when he was only seventeen years of age, he became interested in philosophy—so much so that he continued to attend courses and seminars in philosophy even while a med- ical student at Heidelberg in 1920.
    [Show full text]
  • Current Acetylcholinesterase-Inhibitors: a Neuroinformatics Perspective
    Send Orders for Reprints to [email protected] CNS & Neurological Disorders - Drug Targets, 2014, 13, 391-401 391 Current Acetylcholinesterase-Inhibitors: A Neuroinformatics Perspective Sibhghatulla Shaikh1,†, Anupriya Verma2,†, Saimeen Siddiqui1,†, Syed Sayeed Ahmad2, Syed Mohd. Danish Rizvi1, Shazi Shakil*,2, Deboshree Biswas1, Divya Singh1, Mohd. Haris Siddiqui2, Shahnawaz Shakil3, Shams Tabrez4 and Mohammad Amjad Kamal4 1Department of Biosciences, Integral University, Lucknow-226026, India 2Department of Bio-Engineering, Integral University, Lucknow-226026, India 3Cardinal Health 7000, Cardinal Place, Dublin OH 43017, USA 4King Fahd Medical Research Centre, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia Abstract: This review presents a concise update on the inhibitors of the neuroenzyme, acetylcholinesterase (AChE; EC 3.1.1.7). AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Molecular interactions (mode of binding to the target enzyme), clinical applications and limitations have been summarized for each of the inhibitors discussed. Traditional inhibitors (e.g. physostigmine, tacrine, donepezil, rivastigmine etc.) as well as novel inhibitors like various physostigmine-derivatives have been covered. This is followed by a short glimpse on inhibitors derived from nature (e.g. Huperzine A and B, Galangin). Also, a discussion on ‘hybrid of pre-existing drugs’ has been incorporated. Furthermore, current status of therapeutic applications of AChE- inhibitors has also been summarized. Keywords: Acetylcholinesterase, acetylcholine, physostigmine, rivastigmine, huperzine A. 1. INTRODUCTION gravis (MG) [5], Parkinson’s disease (PD) [6] and other ‘non-classical’ activities such as cell adhesion, neurite The Nobel Prize in Physiology or Medicine 1936 was formation and network formation [7] elicited numerous shared by Sir Henry Hallett Dale and Otto Loewi for their researches relevant to the medical field.
    [Show full text]
  • PART I Basic Neuropharmacology
    PART I Basic Neuropharmacology 1 SOUP OR SPARKS: THE HISTORY OF DRUGS AND SYNAPSES WILLIAM VAN DER KLOOT State University of New York, Stony Brook, New York 1.1 Action of Curare 4 1.2 Bernard’s Career 5 1.3 Scientists, Patrons, and Money 7 1.4 A Changing World 7 1.5 German-Speaking Universities 9 1.6 Michael Forster 9 1.7 Gaskell and Langley 11 1.8 The Synapse 13 1.9 Dale and Loewi 14 1.10 Henry Wellcome 15 1.11 Ergot and Adrenaline 15 1.12 Histamine 16 1.13 Acetylcholine 17 1.14 National Institute for Medical Research 17 1.15 Loewi’s Experiment 18 1.16 Feldberg 20 1.17 Nobel Prize of 1936 21 1.18 Electric Organ 22 1.19 Eccles, Kuffler, and Katz 22 1.20 Nachmansohn 23 1.21 Postwar Science 24 1.22 Bovet 25 1.23 Ion Channels 25 1.24 Soup, not Sparks 25 1.25 Actions of þ TC 27 1.26 Synaptic Vesicles 27 1.27 Cloning The nAChR 27 1.28 How Can Chemical Transmission Be So Fast? 28 1.29 Eccles and Central Synapses 28 1.30 Adrenergic Transmitters in CNS 29 1.31 Carlsson 30 Handbook of Contemporary Neuropharmacology, Edited by David R. Sibley, Israel Hanin, Michael Kuhar, and Phil Skolnick. Copyright r 2007 John Wiley & Sons, Inc. 3 4 SOUP OR SPARKS: THE HISTORY OF DRUGS AND SYNAPSES 1.32 Second Messengers 31 1.33 Amino Acid Transmitters 32 1.34 Kuffler 32 1.35 End of the Era 33 1.36 Conclusions 34 Acknowledgments 34 References 35 1.1 ACTION OF CURARE Claude Bernard (1813–1878; Fig.
    [Show full text]
  • Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System Alexander C
    NEUROPSYCHOPHARMACOIOGY 1993-VOL. 9, NO.3 181 Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System Alexander C. Karczmar, Ph.D. This year marks the seventieth anniversary of Otto second messengers and G proteins; synthesis, storage Loewi's demonstration of chemical transmission generally and release of acetylcholine; cholinesterases, and autonomic cholinergic transmission specifically and anticholinesterases, and war gases; central cholinergic the fortieth anniversary of John Eccles's proof of the pathways; central cholinergic functions, behaviors, existence of central cholinergic transmission. Following cholinergic EEG and REM sleep; cholinergic ontogeny these epochal findings, the subsequent studies of the and teratology; trophic phenomena; and the clinical cholinergic system led to discoveries of similarly aspects of the cholinergic system. This review refers to important phenomena. This review concerns these the history as well as the present status of each of these phenomena, including chemical structure and molecular phenomena; furthermore, it describes briefly the biology of cholinergic receptors; electrophysiologic and nineteenth-century work with calabar bean, pilocarpine, ionic aspects of pre- and postsynaptic cholinergic events; muscarine, and nicotine, that is, the work performed the quantal expression of cholinergic postsynaptic events before the promulgation of the cholinergic era. and activities of their subunits, the elementary events; [Neuropsychopharmacology 9:181-199, 1993J
    [Show full text]
  • The Acetylcholine Nicotinic Receptor
    biomolecules Review Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor Jean-Pierre Changeux Department of Neuroscience, CNRS UMR 3571, Institut Pasteur & Collège de France, 75015 Paris, France; [email protected] Received: 6 February 2020; Accepted: 10 March 2020; Published: 3 April 2020 Abstract: The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the nicotinic acetylcholine receptor, the first neurotransmitter receptor to be identified. Keywords: pharmacological receptor; nicotinic acetylcholine receptor; first identification of a receptor; history of neuroscience The human brain is the most complex organ of the body which cannot be simply regarded as an electrophysiological machine or an electronic computer. Understanding the chemistry of the brain is a prerequisite for the understanding of its functions, in particular the cognitive ones and their pathological alterations. All the operations carried by the billions of its nerve cells and synapses are bound together by chemical signals which mediate information processing in the brain from the molecular to the cognitive level. Neurons produce and release molecules referred to as neurotransmitters, growth factors and/or hormones. These molecules are sent from one cell to another in small packages that deliver their cargo to the right place at the right time in the brain. Fundamental discoveries have been made in the past decades on the precise mechanism of the action of such cargo on their target cells, in other words the signal transduction they bring about.
    [Show full text]
  • The Action of Acetylcholine (Ach) Is Essential Forcontrolling the Permeability Cycle
    VOL. 55, 1966 BIOCHEMISTRY: ROSENBERG ET AL. 835 this "late" message is copied from the original infecting genome or from replicas re- mains unanswered. 1 Cohen, S. S., Federation Proc., 29, 641 (1961). 2Kornberg, A., S. Zimmerman, S. R. Kornberg, and J. Josse, these PROCEEDINGS, 45, 772 (1959). 3DeMars, R. I., Virology, 1, 83 (1955). 4 Wiberg, J. S., M. L. Dirksen, R. H. Epstein, S. E. Luria, and J. M. Buchanan, these PROCEED- INGS, 48, 293 (1962). 5 Hall, B. D., A. P. Nygaard, and M. H. Green, J. Mol. Biol., 9, 143 (1964). 6 Sekiguchi, M., and S. S. Cohen, J. Mol. Biol., 8, 638 (1964). 7 Edlin, G., J. Mol. Biol., 12, 363 (1965). 8 Leive, L., Biochem. Biophys. Res. Commun., 18, 13 (1965). 9 Korn, D., J. J. Protass, and L. Leive, Biochem. Biophys. Res. Commun., 19, 473 (1965). 10 Lowry, 0. H., N. J. Rosebrough, A. J. Farr, and R. J. Randall, J. Biol. Chem., 193, 265 (1951). 11 Levinthal, C., D. P. Fan, A. Higa, and R. A. Zimmerman, in Cold Spring Harbor Symposia on Quantitative Biology, vol. 28 (1963), p. 183. 12Hurwitz, J., J. J. Furth, M. Malamy, and M. Alexander, these PROCEEDINGS, 48, 1222 (1962). SIMILARITY OF EFFECTS OF OXYGEN, SULFUR, AND SELENIUM ISOLOGS ON THE ACETYLCHOLINE RECEPTOR IN EXCITABLE MEMBRANES OF JUNCTIONS AND AXONS* BY PHILIP ROSENBERG, HENRY G. MAUTNER, AND DAVID NACHMANSOHN DEPARTMENTS OF NEUROLOGY AND BIOCHEMISTRY, COLLEGE OF PHYSICIANS AND SURGEONS, COLUMBIA UNIVERSITY, AND DEPARTMENT OF PHARMACOLOGY, YALE UNIVERSITY Communicated February 18, 1966 Excitable membranes have, during electrical activity, the ability of changing their permeability to ions in a specific, rapid, and reversible way.
    [Show full text]