The Friedman Brain Institute is proud to present the ninth issue of the FBI Informant. The Informant is a triennial newsletter highlighting announcements and events for basic and clinical neuroscience at Mount Sinai. The purpose of riedman rain nstitute the Informant is to keep everyone abreast of all that is going on in and out of the F B I labs and clinics that comprise the Friedman Brain Institute, as well as acknowledge those individuals responsible for its success. In addition to sharing the information, our hope is that the Informant can be used as a tool to inspire, informant congratulate, and support one another.

Announcements

Happy New Year! As we move into 2013 and I prepare the 9th issue of the Informant, I am amazed at how quickly time passes. Once again, I would like to thank everyone for yet another incredible year for the Informant made possible only through your contributions and continued support.

Han Lab (Pharmacology and Systems Therapeutics)

Recent Publications: • Chaudhury D*, Walsh JJ*, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel D, Nectow AR, Ekstrand M, Domingos A, Mazie-Robison M, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. Rapid regulation of depression-like behaviors by control of midbrain dopamine neurons. Nature. 2012 Dec 12; doi: 10.1038/nature11713 [* contributed equally]

• Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ. Neurobiology of resilience. Nature Neuroscience. 2012 Nov; 15(11):1475-84.

• Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez- Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ. BDNF is a negative modulator of morphine action. Science. 2012 Oct 5; 338(6103):124-8.

• Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks A, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, and González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience. 2012 Sep;15(9): 1245-54.

Jessica Walsh (PhD Student)

Jessica Walsh is the recipient of the 2012 Hausfeld Award.

This is an award that is given to the most outstanding senior PhD student in Neuroscience. The award was established through a generous gift from Dr. David Hausfeld, who wanted to provide a mechanism to reward particularly outstanding students pursuing Neuroscience in the Graduate School of Biomedical Sciences at Mount Sinai. Jessica has performed at the top of her class in all of the required coursework, and her performance on the qualifying exams was exemplary. Most importantly, her thesis work in the laboratory of Dr. Ming-Hu Han has been at the highest level, both with respect to technical innovation and scientific impact. Jessica received a prestigious predoctoral fellowship from NIH with one of the highest review scores possible. Finally, Jessica’s ground-breaking work on the dopaminergic system was recently accepted for publication in the journal, Nature, an outstanding accomplishment.

Congratulations Jessica!

1 Harel Lab (Neurology)

New Grant: VA Rehabilitation Research & Development Service Career Development Award: "A Hebbian approach to regaining control of spared circuits in spinal cord injury"

Recent Publications: • Harel NY, Asselin PK, Fineberg DB, Pisano TJ, Bauman WA, Spungen, AM. Adaptation of computerized posturography to assess seated balance in persons with spinal cord injury. J Spinal Cord Med, in press.

Pasinetti Lab (Neurology)

We congratulate Dr. Lap Ho on his promotion to Associate Professor on the research track.

Dr. Pasinetti was recently awarded research grants from the Department of Defense and from the Alzheimer’s Association of America with Dr. Gong. Dr. Pasinetti developed a new Sponsored Research Agreement between MSSM and Io Therapeuics, Inc. for the development of the compound IRX4204, currently used for the treatment of cancer, to possibly treat Alzheimer’s disease. Dr. Pasinetti was invited to deliver a keynote speech at the International Drug Discovery Science and Technology conference in Nanjing, China, where he discussed “The Science of Repurposing Drugs in Alzheimer's Disease Therapeutics”.

Simonyan Lab (Neurology)

Mount Sinai School of Medicine Awarded More Than $5 Million from NIH To Study A Rare Movement Disorder, Spasmodic Dysphonia

Kristina Simonyan, MD, PhD, Assistant Professor of Neurology and Otolaryngology at Mount Sinai School of Medicine, has received two five-year R01 awards over $5 Million from the National Institute on Deafness and Other Communication Disorders (NIH) to study causes and pathophysiology of spasmodic dysphonia (SD), a rare form of primary focal dystonia affecting the laryngeal muscles. SD develops spontaneously in midlife and progresses to become a chronic debilitating condition, which impacts nearly every aspect of a patient’s life, causing emotional stress, loss of employment, social embarrassment and isolation. The causes and pathophysiology of SD are unknown, and the treatment is limited to symptomatic management of the disorder.

By combining multi-modal brain imaging and next-generation DNA sequencing, Dr. Simonyan’s team will examine genetically modified differences in brain abnormalities in large populations of patients with different phenotypes of spasmodic dysphonia. Identification of SD imaging endophenotypes and the associated genetic susceptibility risk factors will help characterization of diagnostic biomarkers of this disorder, which are needed for detection and evaluation of SD patients as well as for screening of persons at risk for SD development.

Dr. Simonyan’s team will also examine the central mechanisms of action of a novel oral medication, sodium oxybate (Xyrem®), as a treatment option for patients with SD and vocal tremor, many of who have failed available therapies. The use of advanced neuroimaging methodologies together with extensive analyses of brain functional and structural organization in these patients is anticipated to yield novel results, which will be critical for the establishment of criteria for improved clinical management of these disorders.

Huntley Lab (Neuroscience)

Recent Publications: • Huntley GW, Synaptic circuit remodelling by matrix metalloproteinases in health and disease., Nature Reviews Neuroscience. 2012 13:743-57.

2 Hof Lab (Neuroscience)

Dr Hof was a senior contributor to the Allen Institute for Brain Science's large-scale effort to map the human brain transcriptome. He served as the Chair of the Advisory Board for the Institute's Human Brain Project and as a key consultant on human brain anatomy. The human brain transcriptome atlas was recently published in Nature.

The Hof lab welcomes Angelique Petropouleas, a new Masters student, and says a warm good-bye to Aniruddha Yadav who completed his postdoc and will return to India.

Recent Publications: • Gu X, Liu X, Van Dam NT, Hof PR, Fan J. Cognition-emotion integration in the anterior insular cortex, Cereb Cortex 2013;23:20-27.

• Fan J, Bernardi S, Dam NT, Anagnostou E, Gu X, Martin L, Park Y, Liu X, Kolevzon A, Soorya L, Grodberg D, Hollander E, Hof PR. Functional deficits of the attentional networks in autism, Brain Behav. 2012;2:647-660.

• Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI., Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices., J Neurosci. 2012;32:13644-13660.

• Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC., Prolonged myelination in human neocortical evolution., Proc Natl Acad Sci USA. 2012;109:16480-16485.

• Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR., An anatomically comprehensive atlas of the adult human brain transcriptome.,Nature. 2012;489:391-399.

Shen Lab (Neuroscience)

Recent Publications: • Sun H, Maze I, Dietz DM, Scobie KN, Kennedy PJ, Damez-Werno D, Neve RL, Zachariou V, Shen L and Nestler EJ (2012) Morphine Epigenomically Regulates Behavior through Alterations in Histone H3 Lysine 9 Dimethylation in the Nucleus Accumbens, The Journal of Neuroscience, 32, 17454-17464.

• Warren BL, Vialou VF, Iñiguez SD, Alcantara LF, Wright KN, Feng J, Kennedy PJ, LaPlant Q, Shen L, Nestler EJ and Bolaños-Guzmán CA (in press) Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice, Biological Psychiatry.

Filizola Lab (Structural and Chemical Biology)

• Dr. Filizola’s work on integrins is featured in the 2012 Annual Report of the Pittsburgh Supercomputing Center (http://www.psc.edu/science/2012/antonepics/) • Dr. Filizola’s Nature News and Views article on “How opioid drugs bind to receptors” (with Dr. Lakshmi Devi) is featured in the 2012 Editor's Choice

Recent Publications: • Filizola M & Devi LA “Grand Opening of Structure-Guided Design for Novel Opioids” Trends in Pharmacological Sciences (2012) Nov 2. doi:pii: S0165-6147(12)00177-0. 10.1016/j.tips. 2012.10.002. [Epub ahead of print; PMID:23127545] 3

3 Brennand Lab (Psychiatry)

Dr. Brennand was recently awarded a NARSAD Young Investigator Grant from the Brain and Behaviour Research Foundation.

Recent Publications: • Tran NN, Ladran IG, Brennand KJ. Modeling Schizophrenia Using Induced Pluripotent Stem Cell- Derived and Fibroblast-Induced Neurons. Schizophr Bull. 2012 Nov 19. [Epub ahead of print]

Buxbaum Lab (Psychiatry)

Recent Publications: • Bozdagi O, Sakurai T, Dorr N, Pilorge M, Takahashi N, Buxbaum JD. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One 2012;7(8):e42422.

• Buxbaum JD, Daly MJ, Devlin B, Lehner T, Roeder K, State MW, and The Autism Sequencing Consortium. The Autism Sequencing Consortium: Large-Scale, High-Throughput Sequencing in Autism Spectrum Disorders. Neuron 2012.

• Yang M, Bozdagi O, Scattoni ML, Wöhr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN. Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent shank3 null mutant mice. J Neurosci 2012, 32:6525-6541.

Maeso Lab (Psychiatry)

A new postdoc joined the Maeso lab. Daisuke Ibi arrived in November from Nagoya University. He was awarded a fellowship from the Society for the Promotion of Science (Japan).

Recent Publications: • Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Hanks J, Seto J, Callado LF, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, González-Maeso J. Identification of three residues essential for 5-HT2A-mGlu2 receptor heteromerization and its psychoactive behavioral function. Journal of Biological Chemistry 287:44301-44319 (2012).

• Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, González-Maeso J. Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects. European Neuropsychopharmacology (2012). Epub ahead of print.

• Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal stress induces schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring: Role of maternal immune system. Journal of Neuroscience (accepted).

• Hanks J, González-Maeso J. Animal models of serotonergic psychedelics. ACS Chemical Neuroscience (accepted) **Special Issue: Celebrating 25 years of the serotonin club.

• Kurita M, Holloway T, González-Maeso J. HDAC2 as a new target to improve schizophrenia treatment. Expert Review of Neurotherapeutics (accepted).

4 Nikolaos Daskalakis (Postdoctroral Research Fellow)

Dr. Daskalakis, working as a postdoctoral fellow under the supervision of Dr. Yehuda and Dr. Buxbaum, was given a FENS/IBRO grant to participate to the FENS Forum in Barcelona and to present the following oral presentation in the EBBS satellite symposium: Daskalakis NP, Meelis W, Fung WLJ, de Jong IEM, McNeilly J, McNeilly AS, Didriksen M, Cools AR, de Kloet ER: Animal model of differential susceptibility to social environment: implications for schizophrenia."

Recent Publications: • Claessens SE, Daskalakis NP, Oitzl MS, de Kloet ER. Early handling modulates outcome of neonatal dexamethasone exposure. Horm Behav. 2012 Sep;62(4):433-41. doi: 10.1016/j.yhbeh.2012.07.011.

• Tiemensma J, Daskalakis NP, van der Veen EM, Ramondt S, Richardson SK, Broadbent E, Romijn JA, Pereira AM, Biermasz NR, Kaptein AA. Drawings reflect a new dimension of the psychological impact of long-term remission of Cushing's syndrome. J Clin Endocrinol Metab. 2012 Sep;97(9):3123-31. doi: 10.1210/jc.2012-1235.

• Daskalakis NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol Behav. 2012 Jul 16;106(5):707-21. doi: 10.1016/j.physbeh.2012.01.015

Dillon Chen (MD/PhD Student) and Dhananjay Bambah-Mukku (PhD Student)

Congratulations to Dillon and DJ on their new publication in which they were co-first authors.

Chen DY, Bambah-Mukku D, Pollonini G, Alberini CM., Glucocorticoid receptors recruit the CaMKIIα- BDNF-CREB pathways to mediate memory consolidation., Nat Neurosci. 2012 Nov;15(12):1707-14.

The article was also featured in Nature Reviews Neuroscience as a Research Highlight: http://www.nature.com/nrn/journal/vaop/ncurrent/full/nrn3416.html

Sarah Motley (PhD Student), Kate Seip-Cammack (Post-doc) and Sarah Levinson (PhD Student)

"Congratulations to Sarah Motley, Kate Seip-Cammack and Sarah Levinson, the leaders of Women in Science (WIS), for their new positions on the Board of Directors for the Office for Women's Careers."

Welcome New Faculty to the Psychiatry Department:

Tanja Auf der Heyde, PhD.

Dr. Auf der Heyde will serve as Assistant Clinical Professor of Psychiatry and Faculty Practice Associate in the World Trade Center (WTC) Mental Health Monitoring and Treatment Program.

Dr. Auf der Heyde’s research interests include the applications of psychodynamic psychotherapy to the treatment of traumatic stress and comorbid personality disorders, as well as their integration with other evidence-based practices. She is also studying the treatment of psychotic spectrum disorders, and the relationship between trauma and the development of psychosis.

Prior to joining Mount Sinai, Dr. Auf der Heyde was a post-doctoral fellow at the William Alanson White Institute in City. During her internship training at the Bronx Psychiatric Center, she worked primarily with a severely mentally ill forensic population. Dr. Auf der Heyde earned her doctorate from The City University of New York, focusing on disruptions in interpersonal rhythms as a result of a history of trauma.

5 Welcome New Faculty to the Psychiatry Department (continued):

Anne-Claude V. Bédard, PhD. Dr. Bédard will serve as Assistant Professor (Research Track) in the clinical and translational ADHD research program in the Division of Child and Adolescent Psychiatry. In her new role, Dr. Bédard will continue her research on impaired cognition in childhood neuropsychiatric disorders, with the ultimate goal of developing effective compensatory strategies or interventions that will improve cognitive performance and influence the trajectory of such disorders. Her work is also focused on examining the brain mechanisms underlying working memory in youth with and without ADHD, and in particular, the neural effects subserving the therapeutic effects of guanfacine on working memory. Dr. Bédard’s past research has helped elucidate the effects of methylphenidate on critical cognitive processes such as working memory and inhibitory. Her findings have also been influential in developing conceptualizations regarding the core deficits in ADHD, among which spatial working memory is emerging as an important construct. In 2010, Dr. Bédard was awarded a grant from the Klingenstein Third Generation Foundation, and in 2012 she received the Mount Sinai Robin Chemers Neustein Postdoctoral Fellowship to conduct innovative research integrating her long- standing interests in spatial working memory and psychopharmacology with her newly developed neuroimaging skills. Prior to joining Mount Sinai, Dr. Bédard completed her doctorate at the University of in Medical Science/ Neuroscience where she conducted a highly influential series of studies in neurocognition as it relates to ADHD.

Peter Glick, PhD. Dr. Glick will serve as Assistant Professor of Psychiatry in the World Trade Center (WTC) Mental Health Monitoring and Treatment Program. Trained in psychodynamic theory, he incorporates interventions across modalities including cognitive behavioral therapy, dialectical behavior therapy, and other behavioral strategies. Dr. Glick recently co-published a chapter in a book about the psycholinguistics of self-deceptive speech and is preparing his dissertation for publication. He was the recipient of a number of distinctions including a University Fellowship and The Irwin Rock Memorial Award in Psychology for his dissertation investigating ruptures in the therapeutic alliance. Prior to joining Mount Sinai, Dr. Glick completed his postdoctoral fellowship in the Psychiatric Recovery Center at St. Luke’s-Roosevelt Hospital focusing on severe and persistent mental illness. He also helped train psychology interns, externs, and psychiatry residents in psychotherapy. Dr. Glick earned his doctorate in clinical psychology from the New School for Social Research and completed his predoctoral internship at New York Presbyterian Hospital/Columbia University Medical Center.

Dorothy E. Grice, MD. Dr. Grice will serve as Professor of Psychiatry in the recently formed Division of Tics, Obsessive- Compulsive, and Related Disorders (DTOR). DTOR encompasses an array of related conditions characterized by repetitive behaviors with onset in childhood or early adulthood. In her new role, Dr. Grice will have an active research program that focuses on the biology, genetics, and phenomenology of OCD, tic and autism spectrum disorders. She will be Chief of the OCD and Related Disorders Clinical and Research Program and Associate Director of the Tics and Tourette’s Clinical and Research Program, within DTOR. Dr. Grice completed advanced clinical and research training in child psychiatry at the Yale Child Study Center through the National Institute of Health Research Training Program in childhood neurobiological disorders. Prior to joining Mount Sinai, Dr. Grice was at Columbia University/New York State Psychiatric Institute where she was the Genetics Principal Investigator at the Columbia University Simons Simplex Collection. While at Columbia, she established a DNA repository for all research participants within the Division of Child Psychiatry and directed the Tic, Tourette, and Related Disorders Clinic at Children’s Hospital of New York/New York Presbyterian Hospital. Dr. Grice received her medical degree from the Medical University of South Carolina and is currently completing her masters of science in bioethics at Columbia University. 6

6 Welcome New Faculty to the Psychiatry Department (continued):

Roy Jerome, PhD.

Dr. Jerome will serve as Assistant Professor of Psychology and work as a staff psychologist within the Comprehensive Health Program-Downtown, which provides primary and specialty care to patients in our community with HIV/AIDS.

Dr. Jerome’s areas of expertise include substance use disorders, sexual health, HIV, Hepatitis C (HCV), pain management, trauma-focused therapies, post-traumatic stress disorder, and men’s mental health. His research focuses on methamphetamine use, HIV-risk, and trauma.

Prior to joining Mount Sinai, Dr. Jerome was a postdoctoral psychology fellow in HIV and HCV at the San Francisco VA Medical Center. During his training, he developed an early-recovery treatment protocol for patients with methamphetamine use disorders. Dr. Jerome also focused on behavioral health treatments for patients undergoing novel interferon treatment for Hepatitis C. He earned his doctorate from New York University where he conducted research on methamphetamine use and HIV-risk among black gay and bisexual men in .

Matthew Majeske, MD.

Dr. Majeske will serve as Assistant Clinical Professor of Psychiatry and Chief of the Geriatric Psychiatry Clinic.

A nationally recognized expert in electroconvulsive therapy (ECT), Dr. Majeske will be a member of Mount Sinai’s ECT service and provide consultation and treatment to patients referred for ECT. In his new role, he will also work as a study psychiatrist on the clinical trial, PRIDE, which compares the effects of ECT with the use of medication alone in prolonging remission from depression in elderly patients. Dr. Majeske’s clinical interests also include treatment-resistant mood disorders, geriatric psychiatry, forensic psychiatry, and lesbian, gay, bisexual and transgender issues.

Dr. Majeske has a long background in New York City teaching hospitals. For nearly 20 years, he was Unit Chief at St. Vincent’s Hospital until the facility closed. During his tenure at St. Vincent’s, he also directed the ECT service. Prior to joining Mount Sinai, he was Director of the Adult Inpatient Service at Elmhurst Hospital Center as well as Assistant Professor of Psychiatry at New York Medical College.

Born and raised in Michigan, Dr. Majeske completed his medical degree and residency at the University of Michigan, Ann Arbor. He received his fellowship training in forensic psychiatry at New York University.

Joshua Morris, MD.

Dr. Morris will serve as Attending Psychiatrist and Assistant Professor on the Adult Inpatient Service at Mount Sinai Hospital.

Dr. Morris will provide outpatient treatment for psychiatric patients, specializing in the diagnosis and management of anxiety, depression, bipolar disorder, and personality disorders. Board-eligible in psychiatry, Dr. Morris is trained to use pharmacotherapy, individual psychodynamic psychotherapy, and group psychotherapy. He is also certified to perform electroconvulsive therapy. In his new role, he will also supervise residents and medical students.

Prior to joining Mount Sinai, Dr. Morris completed a four-year residency program at the Zucker Hillside Hospital-North Shore-Long Island Jewish. During his residency, he co-investigated the demographic characteristics of patients who received clozapine or long-acting injectable antipsychotics in a busy, academic, inpatient setting. His senior paper, based on this research, received an award from the Queens County Psychiatric Association. Dr. Morris earned his medical degree from the Medical College of Georgia in Augusta. 7

7 Welcome New Faculty to the Psychiatry Department (continued):

Avi (Abraham) Reichenberg, PhD.

Dr. Reichenberg will serve as Professor of Psychiatry, work closely with the Seaver Autism Center, and hold a secondary appointment in Preventive Medicine. Nationally and internationally known for his developmental and neuropsychological studies in schizophrenia, Dr. Reichenberg was the first scientist to describe the increased risk for advanced paternal age in autism, and has provided molecular mechanisms for these findings. In his new role, Dr. Reichenberg will augment Mount Sinai's research efforts in the area of psychiatric epidemiology and play an important role in enhancing the translational research program at the Seaver Autism Center. He will also aid in the development of the Divisions of Neurodevelopmental Disorders and Psychiatric Genomics by adding psychiatric epidemiology to these programs while contributing to larger efforts in neuropsychiatric analyses. Dr. Reichenberg’s expertise will enable many Mount Sinai researchers to introduce epidemiology dimensions to their studies, which will maximize their ability to obtain NIH research grants. His own research will focus on human and animal models in the context of the epidemiology of psychiatric disease. Prior to joining Mount Sinai, Dr. Reichenberg was a Professor in Epidemiology in the Department of Psychosis Studies at King’s College in London. He earned his doctorate, master’s and bachelor degrees from The Hebrew University of Jerusalem in Israel.

Luis H. Ripoll, MD.

Dr. Ripoll will serve as Assistant Professor of Psychiatry in the World Trade Center (WTC) Mental Health Monitoring and Treatment Program. Dr. Ripoll’s research interests include the neurobiological basis of personality differences in social cognition, identity, alexithymia, and aggression; developmental influences of attachment insecurity on neurobiological functioning; psychotherapy process research; and evidence-based treatments for personality disorders.

Dr. Ripoll earned his medical degree from the University of Florida College of Medicine in their research track, and completed his adult psychiatry residency at Mount Sinai where he served as Chief Resident. During his residency, Dr. Ripoll pursued additional expertise in the treatment of post-traumatic stress disorder and dissociative disorders, dialectical behavior therapy, and psychodynamic psychotherapy. He also pursued a James J. Peters VA MIRECC Psychiatric Clinical Research Fellowship, working primarily in Mount Sinai's Mood and Personality Research Program.

Ariz Rojas, PhD.

Dr. Rojas will serve as Assistant Professor in the Division of Tics, Obsessive-Compulsive, and Related Disorders. Dr. Rojas specializes in evaluating and treating children, adolescents, and adults with obsessive- compulsive spectrum disorders, tic disorders, anxiety disorders, and ADHD. She also supervises research assistants, graduate students, and residents as well as delivers lectures on cognitive behavioral therapy. Her clinical research has focused on evidence-based treatments for pediatric OCD, parent-child interventions, and the role of acculturation in the mental health of Hispanic youth. She first came to Mount Sinai in 2011 as a postdoctoral fellow working in the Obsessive-Compulsive Disorders Treatment Center and the Center for Excellence in ADHD and Related Disorders. During her fellowship, Dr. Rojas conducted diagnostic evaluations, cognitive behavioral therapy, exposure and response prevention, habit reversal, group therapy, parent management training, and psychological testing. She was also responsible for supervising and teaching clinical psychology externs and psychiatry residents. Prior to joining Mount Sinai, she completed a predoctoral internship in clinical child and pediatric psychology at Children’s Hospital Boston at Harvard Medical School. She received her doctoral degree in clinical psychology from the University of South Florida with a concentration in pediatric psychology. She was also a recipient of the Ford Foundation Predoctoral Fellowship from the National Academy of Sciences. 8

8 Welcome New Faculty to the Psychiatry Department (continued):

Corneliu Sanda, MD.

Dr. Sanda will serve as Assistant Professor and work full-time in the inpatient Dual Diagnostic Unit at Mount Sinai Hospital.

Board-certified in general psychiatry and addiction psychiatry, Dr. Sanda is a licensed prescriber of Buprenorphine, a novel treatment for opiate dependence, and has an expertise in addiction psychiatry. During his post-doctoral training at Indiana University, he worked in a cellular biology laboratory and published several articles in national and international journals on Hepatitis B and its treatment.

Prior to joining Mount Sinai, Dr. Sanda pursued his general psychiatry residency training at Harlem Hospital—a community hospital affiliated with Columbia University. Later, he completed a psychiatry fellowship in addiction at Mount Sinai. Dr. Sanda received his medical degree from Carol Davila University, the leading medical school in Romania.

Jan Schuetz-Mueller, MD.

Dr. Schuetz-Mueller will serve as Assistant Clinical Professor of Psychiatry and Unit Chief of an adult inpatient psychiatric unit where he specializes in working with patients who have severe chronic mental illness.

In his new role, Dr. Schuetz-Mueller will treat patients and teach medical students and residents. As Associate Director of the Mount Sinai Program in Global Mental Health, he will coordinate several projects at international field sites that will improve psychiatric care in foreign countries. Such projects include developing child and adolescent psychiatry in Belize and creating an Alcoholics Anonymous program in the Caribbean islands of Saint Vincent and the Grenadines. He will also mentor medical students and residents in the global health track.

Dr. Schuetz-Mueller completed his residency in psychiatry and a fellowship in psychiatric hospitalism and administration at Mount Sinai. He earned his doctorate in medicine from the Medical University of Vienna in Austria.

Eli Stahl, PhD.

Dr. Stahl will serve as Assistant Professor and be engaged in full-time academic activities in the new Center for Statistical Genetics, which is jointly based in the Departments of Psychiatry, and Genetics and Genomic Sciences. Throughout his career, Dr. Stahl has established a national reputation for developing and applying novel methods in studies of complex disease. Recently, his research on polygenic modeling to inform genetic architecture was featured as part of a first-author manuscript in Nature Genetics.

In his new role, Dr. Stahl will help strengthen our expertise in genomics and genomic medicine, particularly in the application of genetic methods to other non-psychiatric illness. He will work closely with the Institute of Genomics and Multiscale Biology, and the Institute for Personalized Medicine, to foster collaboration among Mount Sinai researchers.

Prior to joining Mount Sinai, Dr. Stahl was a research associate in the Division of Rheumatology, Immunology, and Allergy at Brigham and Women’s Hospital at Harvard Medical School and an Affiliated Researcher in the Medical and Population Genetics Program at the Broad Institute of Harvard and MIT. He received his doctorate in genetics from the University of and his bachelor degree from the University of California, Davis. 9

9 New Grants: PI Agency Title/Description

Ana Akerstedt, NEUROL EFA Moderators of Neuropsychological Test Performance in Older Adults with TLE Kristen Brennand, PSY NARSAD Modeling Schizophrenia Using Human Induced Pluripotent Stem Cells: Assessing the Contribution of Glutamatergic and Dopaminergic Neurons to Disease Mingjia Dai, NEUROL NIH Pilot study on Mal de Debarquement Wayne A. Gordon, REHAB CDC Mount Sinai Injury Control Research Center Wayne A. Gordon, REHAB NIDRR Mount Sinai Traumatic Brain Injury Model System of Care Matilde Inglese, NEUROL Novartis Identification and validation of tissue-specific MRI markers to assess protection and repair in response to Fingolimod. Matilde Inglese, NEUROL Novartis Identification and validation of tissue-specific multimodal MRI to assess protection and repair Sylvia Klineova, NEUROL NMSS MS Clinical Care Physician Fellowship Fred Lublin, NEUROL Revalesio Revalesio RNS60 Planning Grant Steven Moore, NEUROL NASA Assessment of Operator Proficiency Following Long-Duration Space Flight Eric Nestler, NEU Janssen R&D Analysis of blood and brain tissue from mice subjected to chronic social defeat stress Giulio Pasinetti, NEUROL Io Therapeutics Investigation of IRX4204 as a Disease Modifying Agent of Alzheimer's Disease Neuropathology and Cognitive Impairment Giulio Pasinetti, NEUROL US Army Down-Regulation of Olfactory Receptors in Response to Traumatic Brain InjuryPromotes Risk of Alzheimer's Disease Scott Russo, NEU NIH Sex Differences in Stress-Induced Genome-Wide Transcriptional Profiles. Paul Slesinger , NEU BSF Interactions between presynaptic GABA(B) and muscarinic receptors at hippocampal boutons Venetia Zachariou, NEU NIH (PPG) Molecular Neurobiology of Drug Addiction - Proj. 4 Jeanne Zanca, REHAB Dept. of Defense Systematic Assessment of Skill Performance by Persons with Tetraplegia and Their Caregivers Jenny Zou, NEU American Heart Chromatin Plasticity in Enhancing Neural Stem Cell Response to Association Cerebral Ischemia

Awards: PI Award Association Kristjan T. Ragnarsson, REHAB Humanitarian Award National Spinal Cord Injury Association Kristjan T. Ragnarsson, REHAB Presidential Award American Association of Academic Physiatrists Kristjan T. Ragnarsson, REHAB John W. Goldsmith National Rehabilitation Hospital Award for Excellence in Rehabilitation Marcel Dijkers, REHAB Gold Key Award American Congress of Rehabilitation Medicine

Fellowships:

Katharine Cammack NRSA - F32 Heroin withdrawal: modulation of aversive states by kappa opioid receptors

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10 In the News:

NIH Awards $100M for Autism Centers of Excellence Research Program The NIH has granted $100 million for Autism Centers of Excellence (ACE) research program featuring projects investigating sex differences in autism spectrum disorders, or ASD, and investigating ASD and limited speech. The nine awards for 2012 will support research at individual centers or at research networks, which involve multiple institutions, dedicated to the study of ASD. Abraham Reichenberg, PhD, Mount Sinai School of Medicine, and researchers will embark on an ambitious attempt to understand how genetic and environmental factors influence the development of autism. The researchers will analyze detailed records and biospecimens from 4.5 million births involving 20,000 cases of ASD, from seven countries. The analysis will span three generations and involve grandparents, parents, aunts, uncles, and siblings and cousins. Dr. Avi Reichenberg, Psychiatry Learn more: http://pharmabiz.com/NewsDetails.aspx?aid=71011&sid=2

Why Fathers Really Matter That food and poison change us is not all that surprising, even if it is surprising how far down the change goes. What is unexpected are the psychological dimensions of epigenetics. To learn more about these, I visited The Mount Sinai Medical Center laboratory of Dr. Eric Nestler, a psychiatrist who did a discomfiting study on male mice and what he calls “social defeat.” His researchers put small normal field mice in cages with big, nasty retired breeders, and let the big mice attack the smaller mice for about five minutes a day. If a mean mouse and a little mouse were pried apart by means of a screen, the torturer would claw at the screen, trying to get at his victim. All this subjected the field mouse to “a horrendous level of stress,” Dr. Nestler said. Dr. Eric Nestler, Professor & Chair, Neuroscience Learn more: http://www.nytimes.com/2012/09/09/opinion/sunday/why-fathers-really-matter.html?pagewanted=all

New Insight Into Basis Of Opiate Addiction Chronic morphine exposure has the opposite effect on the brain compared to cocaine in mice, providing new insight into the basis of opiate addiction, according to Mount Sinai School of Medicine researchers. They found that a protein called brain-derived neurotrophic factor (BDNF), which is increased in cocaine addiction, is inhibited in opioid addiction. "Our study shows that BDNF responds completely differently with opioid administration compared to cocaine," said Ja Wook Koo, PhD, Postdoctoral Fellow in the Department of Neuroscience at Mount Sinai School of Medicine. "Morphine creates reward by inhibiting BDNF, whereas cocaine acts by enhancing BDNF activity." Dr. Ja Wook Koo, Postdoctoral Fellow, Neuroscience Learn more: http://www.news-medical.net/news/20121008/New-insight-into-basis-of-opiate-addiction.aspx

Anterior Insular Cortex Associated With Human Empathy An international team led by researchers at Mount Sinai School of Medicine has for the first time shown that one area of the brain, called the anterior insular cortex, is the activity center of human empathy, whereas other areas of the brain are not. "Now that we know the specific brain mechanisms associated with empathy, we can translate these findings into disease categories and learn why these empathic responses are deficient in neuropsychiatric illnesses, such as autism," said Patrick R. Hof, MD, Regenstreif Professor and Vice-Chair, Department of Neuroscience at Mount Sinai, a co-author of the study. Dr. Patrick R. Hof, Professor and Vice-Chair, Neuroscience Learn more: http://www.news-medical.net/news/20121025/Anterior-insular-cortex-associated-with-human-empathy.aspx

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11 In the News (continued):

Human-Specific Histone Methylation Signatures Found in Prefrontal Cortex There are hundreds of genomic regions that are uniquely regulated in the human brain as compared to other primates, an international team of researchers reported in PLOS Biology this week. Dr. Schahram Akbarian from Mount Sinai School of Medicine homed in on the prefrontal cortex of the brain as it is involved in complex cognitive functions, and changes to its transcriptome are thought to be behind human cognitive abilities as well as disorders. "Much about human biology and disease cannot be deduced by simply sequencing the genome," said Dr. Akbarian. "Mapping the epigenome of neurons and other cells will help us to better understand the inner workings of our brain, and where we are coming from." Dr. Schahram Akbarian, Professor, Psychiatry, Neuroscience Learn more: http://www.genomeweb.com/sequencing/human-specific-histone-methylation-signatures-found-prefrontal-cortex

Changes in Nerve Cells May Contribute to the Development of Mental Illness Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness. Published in Nature Neuroscience, the new study led by Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomics, and Neurology at Mount Sinai, determined that depriving mice of social contact reduced myelin production, demonstrating that the formation of new oligodendrocytes is affected by environmental changes. "We knew that a lack of social interaction early in life impacted myelination in young animals but were unsure if these changes would persist in adulthood," said Dr. Casaccia. "Social isolation of adult mice causes behavioral and structural changes in neurons, but this is the first study to show that it causes myelin dysfunction as well." Dr. Patrizia Casaccia, Professor, Neuroscience, Genetics and Genomics, Neurology Learn more: http://www.sciencedaily.com/releases/2012/11/121128122035.htm

Myelination Exhibits Plasticity, Links to Behavior in Adult Brain Multiple sclerosis is perhaps the best known of the demyelinating disorders, where loss of the insulating sheath surrounding neurons makes high-speed communication impossible. And social isolation, though it does not cause the loss of existing myelin, slows down the formation of new myelin so that animals who are isolated for a period of time ultimately have less myelin than normal. Such is the conclusion of scientists from Mount Sinai School of Medicine, who looked at the effects of isolating adult mice on both forebrain myelination and depression-like behaviors. Senior author Dr. Patrizia Casaccia stressed that unlike in demyelinating diseases, existing myelin does not disappear during social isolation. "We are born with very little myelin," Dr. Casaccia said. Myelination proceeds at a rapid pace during the first few years of life. But it continues, to a lesser degree, for decades. "During the third decade of life, new myelin is still being formed." Dr. Patrizia Casaccia, Professor, Neuroscience, Genetics and Genomics, Neurology Learn more: http://www.bioworld.com/content/myelination-exhibits-plasticity-links-behavior-adult-brain-0

Deep Brain Stimulation To Treat Parkinson's Disease Parkinson's disease has no cure but a device is giving patients hope. "I thought of myself, you know, what I'm going to do for the rest of my life, how I'm going take care of myself, how I'm going take care of my family?" said Jeffrey Joseph, who nine years ago got a diagnosis of Parkinson's disease, a disabling condition that robs the body of normal movement causing uncontrollable tremors. But today you can hardly tell Jeffrey has Parkinson's thanks to a deep brain stimulation device, or DBS, that is implanted in his brain. Dr. Brian Kopell, a neurosurgeon at The Mount Sinai Medical Center, said, "This operation is really about making peoples' lives much better, and the sooner they get into the operating room, the bigger the benefit that they actually will get," he said. “To see people return to a normal lifestyle or more normal lifestyle, there's nothing like it in the world," he said. Dr. Brian Kopell, Associate Professor, Neurosurgery, Co-Director, Center for Neuromodulation Learn more: http://www.myfoxny.com/story/20617876/deep-brain-stimulation-to-treat-parkinsons-disease

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12 Upcoming Calendar:

2nd Annual Cover Contest: Call for Images

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The Friedman Brain Institute will present the 2nd annual cover contest Entry Deadline: January 31, 2013 at 12midnight. during this year’s 5th Annual Neuroscience Retreat

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9:8(6:("&6"5'(I*"$"(+$"(0J%(SAT(>"0*%;/(%'("-0$)N B@(Q$1-<(0*"(1>+<"(0%(0*"(U1<10+4(V";1+(W"-0"$(%-(+('4+/*(;$1,"(%$(WU@ Neuroscience Retreat. The registration website is: http://neuroscience.mssm.edu/

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4!"#$%= #56 What to Enter: The Friedman Brain Institute is looking for high quality, visually FXU\&!\N ((((((((((((((((((I*"(9#$)(J144(M"(+(/"4"50";(3+-"4(5*%/"-(M)(U$/(V+00*"J(7*+31$%(+-;(K-;$"J(W*"//@(K44(1>+<"/(J144(M"(9#;<";(%-(%$1<1-+410)2( ((((((((((((((((((5%>3%/101%-2(%,"$+44(/51"-01'15(1>3+502(+-;(+$01/015(>"$10@ compelling scientific images. Each image must be accompanied with one or two lines &'()%#(*+,"(+-)(.#"/01%-/2(34"+/"('""4('$""(0%(5%-0+50(6"$%-15+(78+$"9:%(+0(;1<10+4=>";1+=5"-0"$?>//>@";#(%$(ABA@CDE@DECA of description.

How to Enter: There are two (2) methods of entry: 1.Bring the image to the Digital Media Center on a flash drive or CD. 2.Upload your image to “Yousendit”: https://www.yousendit.com/ and email it to the DMC at [email protected] Winner: The image selected will be used for the cover of this year’s 5th Annual Neuroscience Retreat pamphlet. Releases: If the photograph contains any material or elements that are not owned by the entrant and/or which are subject to the rights of third parties, a written agreement must be attached and all persons must be credited. Judging: The jury will be a selected panel chosen by Drs Matthew Shapiro and Andrew Chess. All images will be judged on originality, composition, overall scientific impact, and artistic merit.

Brain Awareness Week: March 11-17, 2013 Sinai Neuroscience Outreach Program (SNOP) is hosting its first annual Brain Fair for local students and parents on Tuesday March 12, 2013, as part of Brain Awareness Week. Activities and exhibits will include an animal brain display, pipe cleaner neuron models, helmet safety, and a Brain Myths booth. SNOP is calling on students, postdocs, and research associates to volunteer at this exciting one-day event. Please contact [email protected] if you are interested in designing an exhibit or running an activity.

Visit SNOP's website to learn more: http://sinaineurooutreach.wordpress.com

Save the Date: 5th Annual Neuroscience Retreat

THE FRIEDMAN BRAIN INSTITUTE AND THE NEUROSCIENCE TRAINING AREA When: Friday, April 26, 2013

present th The 5 Annual Where: The New York Academy of Medicine NR euroscience etreat 1216 Fifth Ave (entrance on 103rd St) * Save the Date* Friday, April 26, 2013

Location: New York Academy of Medicine photo by David Carpenter The registration website is now open: http://neuroscience.mssm.edu/retreat/ 1216 Fifth Avenue, New York, New York 10029

For more information, please contact: Marie Kopp at [email protected] or 212-659-5913

13 New Programs: Postdoc Exchange Program

The Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai and the Joseph Sagol Neuroscience Center at the Sheba Medical Center, Israel will begin an exchange postdoc program for neuroscientists. One candidate from each institution will spend two years in a lab of the other institution. Details on the program and on the candidacy procedures will be provided in the beginning of 2013.

Women in Science (WiS) The Women in Science (WiS) group has been established to advocate for the professional and personal goals of the female graduate students and post-doctoral researchers associated with the Icahn School of Medicine at Mount Sinai. The WiS group aims to provide a network of support and mentorship, extend access to professional development and outreach opportunities, and foster an ongoing discussion of concerns specific to the early stages of a female scientist's career. Aims: I. To foster an open dialogue on balancing professional and personal goals, including hosting speakers, workshops, and discussions;

II. To provide opportunities for networking and mentorship, including formal and informal events held on- and off- campus; and

III. To provide information and access to mechanisms designed to advance members' professional goals, including fellowships, grants, and funding opportunities specific to females;

III. To support and advocate the participation and success of girls and women in the sciences in the larger community, including coordinating outreach and volunteer activities within the Sinai community, at local schools and throughout the greater NYC region.

For more information, please contact Sarah Motley at [email protected]

Faculty Publications:

The Neuroscience of Autism Neuropathic Pain: Mechanisms, Spectrum Disorders Diagnosis and Treatment

Editors: By: Joseph Buxbaum David M. Simpson Patrick Hof Justin C. McArthur Robert H. Dworkin

Autophagy of the Nervous System Resilience: The Science of Cellular Self-Digestion in Neurons Mastering Life's Greatest Challenges and Neurological Diseases

Editors: By: Zhenyu Yue Dennis S. Charney Charleen T Chu Steven M. Southwick

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14 New additions to the Neuroscience Department:

Join us in congratulating Scott Russo on the birth of his son.

Jackson Leo Russo - 9 lbs 6 oz

Departures: ❖ The Neuroscience department is sad to see Gloria Yuan leave. We wish her nothing but the best in her future endeavors.

❖ After 38 years of unparalleled dedication and hard work, Carmen Pollock is retiring in February. While the task of finding a replacement will be nearly impossible, we wish nothing but the best for her. Carmen, thank you for all that you have done for us! We will miss you tremendously!

Future issues of the Informant:

Please send updates of your laboratory, clinic, or department for future issues to Veronica Szarejko ([email protected]).

The next issue will be sent out May 1st. All submissions are due April 15th.

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