TACSTD2 (Human) Recombinant Protein (P01)

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TACSTD2 (Human) Recombinant Protein (P01) Catalog # : H00004070-P01 規格 : [ 10 ug ] [ 25 ug ] List All Specification Application Image Product Human TACSTD2 full-length ORF ( AAH09409, 27 a.a. - 323 a.a.) Enzyme-linked Immunoabsorbent Assay Description: recombinant protein with GST-tag at N-terminal. Western Blot (Recombinant Sequence: HTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKC protein) LLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQ TSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHS Antibody Production DLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIG DAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSM Protein Array KRLTAGLIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPS L Host: Wheat Germ (in vitro) Theoretical MW 58.41 (kDa): Preparation in vitro wheat germ expression system Method: Purification: Glutathione Sepharose 4 Fast Flow Quality Control 12.5% SDS-PAGE Stained with Coomassie Blue. Testing: Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. Storage Store at -80°C. Aliquot to avoid repeated freezing and thawing. Instruction: Note: Best use within three months from the date of receipt of this protein. MSDS: Download Datasheet: Download Applications Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Page 1 of 2 2016/5/21 Antibody Production Protein Array Gene Information Entrez GeneID: 4070 GeneBank BC009409 Accession#: Protein AAH09409 Accession#: Gene Name: TACSTD2 Gene Alias: EGP-1,GA733,GA733-1,M1S1,TROP2 Gene tumor-associated calcium signal transducer 2 Description: Omim ID: 137290, 204870 Gene Ontology: Hyperlink Gene Summary: This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq Other OTTHUMP00000011755,epithelial glycoprotein-1,membrane Designations: component, chromosome 1, surface marker 1 (40kD glycoprotein, identified by monoclonal antibody GA733) 服務條款 | 隱私權政策 | 著作及商標 | 網站地圖 ©2016 亞諾法生技股份有限公司 Abnova Corporation. 版權所有. Page 2 of 2 2016/5/21.

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Trop2 and Its Overexpression in Cancers: Regulation and Clinical/ Therapeutic Implications
www.impactjournals.com/Genes&Cancer Genes & Cancer, Vol. 6 (3-4), March 2015 Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications Anna Shvartsur1 and Benjamin Bonavida1 1 Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA Correspondence to: Benjamin Bonavida, email: [email protected] Keywords: cancer, prognosis, resistance, signaling, Trop2 Received: September 29, 2014 Accepted: October 19, 2014 Published: October 19, 2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities. Trop2 is expressed in many normal tissues, though in contrast, it is overexpressed in many cancers and the overexpression of Trop2 is of prognostic significance. Several ligands have been proposed that interact with Trop2. Trop2 signals the cells via different pathways and it is transcriptionally regulated by a complex network of several transcription factors. Trop2 expression in cancer cells has been correlated with drug resistance. Several strategies target Trop2 on cancer cells that include antibodies, antibody fusion proteins, chemical inhibitors, nanoparticles, etc. The in vitro studies and pre-clinical studies, using these various therapeutic treatments, have resulted in significant inhibition of tumor cell growth both in vitro and in vivo in mice.
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