Table of Contents

Foreword...... xvi

Preface...... xviii

Chapter 1 Intelligent Management of Sepsis in the Intensive Care Unit ...... 1 Vicent J. Ribas, Universitat Politècnica de Catalunya, Juan Carlos Ruiz-Rodríguez, Servei de Medicina Intensiva, Grup de Recerca en Shock, Disfunció Orgánica i Ressuscitació, Hospital Universitari Vall d’Hebron, Institut de Recerca Vall d’Hebron, Universitat Autònoma de Barcelona, Spain Alfredo Vellido, Universitat Politècnica de Catalunya, Spain

Chapter 2 Statistical Pattern Recognition Techniques for Early Diagnosis of Diabetic Neuropathy by Posturographic Data ...... 17 Claudia Diamantini, Università Politecnica delle Marche, Italy Sandro Fioretti, Università Politecnica delle Marche, Italy Domenico Potena, Università Politecnica delle Marche, Italy

Chapter 3 Preprocessing MRS Information for Classification of Human Brain Tumours ...... 29 C. J. Arizmendi, Universitat Politècnica de Catalunya, Spain & Universidad Autonoma de Bucaramanga, Colombia A. Vellido, Universitat Politècnica de Catalunya, Spain E. Romero, Universitat Politècnica de Catalunya, Spain

Chapter 4 Semi-Supervised Clustering for the Identification of Different Cancer Types Using the Gene Expression Profiles...... 50 Manuel Martín-Merino, University Pontificia of Salamanca, Spain Chapter 5 Real-Time Robust Heart Rate Estimation Based on Bayesian Framework and Grid Filters ...... 67 Radoslav Bortel, Czech Technical University in Prague, Czech Republic Pavel Sovka, Czech Technical University in Prague, Czech Republic

Chapter 6 Automated Diagnostics of Coronary Artery Disease: Long-Term Results and Recent Advancements...... 91 Matjaž Kukar, , Slovenia Igor Kononenko, University of Ljubljana, Slovenia Ciril Grošelj, University Medical Centre Ljubljana, Slovenia

Chapter 7 The Use of Prediction Reliability Estimates on Imbalanced Datasets: A Case Study of Wall Shear Stress in the Human Carotid Artery Bifurcation...... 113 Domen Košir, University of Ljubljana, Slovenia & Httpool Ltd., Slovenia Zoran Bosnić, University of Ljubljana, Slovenia Igor Kononenko, University of Ljubljana, Slovenia

Chapter 8 Pattern Mining for Outbreak Discovery Preparedness...... 125 Zalizah Awang Long, Malaysia Institute Information Technology, Universiti Kuala Lumpur, Malaysia Abdul Razak Hamdan, Universiti Kebengsaan Malaysia, Malaysia Azuraliza Abu Bakar, Universiti Kebengsaan Malaysia, Malaysia Mazrura Sahani, Universiti Kebengsaan Malaysia, Malaysia

Chapter 9 Development of Surrogate Models of Orthopedic Screws to Improve Biomechanical Performance: Comparisons of Artificial Neural Networks and Multiple Linear Regressions...... 138 Ching-Chi Hsu, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taiwan

Chapter 10 Dashboard to Support the Decision-Making within a Chronic Disease: A Framework for Automatic Generation of Alerts and KPIs...... 160 Leonor Teixeira, / GOVCOPP / IEETA, Portugal Vasco Saavedra, University of Aveiro, Portugal João Pedro Simões, Accenture, Portugal

Chapter 11 Identification of Motor Functions Based on an EEG Analysis ...... 172 Aleš Belič, University of Ljubljana, Slovenia Vito Logar, University of Ljubljana, Slovenia Chapter 12 Visual Data Mining in Physiotherapy Using Self-Organizing Maps: A New Approximation to the Data Analysis...... 187 Yasser Alakhdar, University of , Spain José M. Martínez-Martínez, University of Valencia, Spain Josep Guimerà-Tomás, University of Valencia, Spain Pablo Escandell-Montero, University of Valencia, Spain Josep Benitez, University of Valencia, Spain Emilio Soria-Olivas, University of Valencia, Spain

Chapter 13 Kernel Generative Topographic Mapping of Protein Sequences...... 195 Martha-Ivón Cárdenas, Universitat Politècnica de Catalunya, Spain Alfredo Vellido, Universitat Politècnica de Catalunya, Spain Iván Olier, The University of Manchester, UK Xavier Rovira, Institut de Neurociències, Universitat Autònoma de Barcelona, Spain Jesús Giraldo, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, Spain

Chapter 14 Medical Critiquing Systems...... 209 Ian Douglas, Florida State University, USA

Chapter 15 Learning Probabilistic Graphical Models: A Review of Techniques and Applications in ...... 223 Juan I. Alonso-Barba, University of Castilla-La Mancha, Spain Jens D. Nielsen University of Castilla-La Mancha, Spain Luis de la Ossa, University of Castilla-La Mancha, Spain Jose M. Puerta, University of Castilla-La Mancha, Spain

Chapter 16 Natural Language Processing and Machine Learning Techniques Help Achieve a Better Medical Practice...... 237 Oana Frunza, University of Ottawa, Canada Diana Inkpen, University of Ottawa, Canada

Chapter 17 Modeling Interpretable Fuzzy Rule-Based Classifiers for Medical Decision Support...... 255 Jose M. Alonso, University of Alcala, Spain Ciro Castiello, , Italy Marco Lucarelli, University of Bari, Italy Corrado Mencar, University of Bari, Italy Chapter 18 Extraction of Medical Pathways from Electronic Patient Records...... 273 Dario Antonelli, Politecnico di Torino, Italy Elena Baralis, Politecnico di Torino, Italy Giulia Bruno, Politecnico di Torino, Italy Silvia Chiusano, Politecnico di Torino, Italy Naeem A. Mahoto, Politecnico di Torino, Italy Caterina Petrigni, Politecnico di Torino, Italy

Chapter 19 Building a Lazy Domain Theory for Characterizing Malignant Melanoma ...... 290 Eva Armengol, Artificial Intelligence Research Institute (IIIA-CSIC), Spain Susana Puig, Hospital Clínic i Provincial de Barcelona, Spain

Compilation of References...... 309

About the Contributors...... 334

Index...... 345