Antimicrobal Medicines Consumption (AMC Data: 2011

Total Page:16

File Type:pdf, Size:1020Kb

Antimicrobal Medicines Consumption (AMC Data: 2011 WHO Regional Office for Europe Antimicrobial Medicines Consumption (AMC) Network AMC data 2011–2014 WHO Regional Office for Europe Antimicrobial Medicines Consumption (AMC) Network AMC data 2011–2014 Abstract This report sets out and analyses data on antimicrobial medicines consumption (AMC) collected from non-European Union countries in the WHO European Region and Kosovo (in accordance with Security Council resolution 1244 (1999)). Its aims are to support countries that are building or strengthening their national surveillance systems on AMC and to stimulate the sharing of data both within and between countries. The WHO Regional Office for Europe and its partners remain committed to supporting countries in these endeavours through the activities of the WHO AMC Network. Keywords ANTIMICROBIAL MEDICINES CONSUMPTION NATIONAL SURVEILLANCE NETWORKS ANTI-INFECTIVE AGENTS – THERAPEUTIC USE DRUG RESISTANCE, MICROBIAL EPIDEMIOLOGICAL MONITORING DATA COLLECTION EUROPE Address requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe UN City, Marmorvej 51 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office website (http://www.euro.who.int/pubrequest). ISBN: 9789289052382 © World Health Organization 2017 All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. The views expressed by authors, editors, or expert groups do not necessarily represent the decisions or the stated policy of the World Health Organization. CONTENTS Acknowledgements. vi Foreword. ix Abbreviations . .x Summary . xi 1. Introduction . 1 2. The WHO Antimicrobial Medicines Consumption (AMC) Network. 2 2.1 Background. 2 2.2 Objectives of the WHO AMC Network. 3 2.3 Participating countries and areas . 4 3. Data collection and analysis . 5 3.1 Methodology. .5 3.2 Data collection. .6 3.3 Data analysis. .7 3.4 Data interpretation. 10 4. Albania . 12 4.1 Data sources and years of data collection. 12 4.2 Estimates of volumes of consumption of J01 anti-infective agents. 12 4.3 Relative consumption of J01 anti-infective agents by subgroup. 14 4.4 Relative consumption by choice of agent. 16 4.5 The 10 most consumed agents . 20 4.6 Comments. 21 5. Armenia . 22 5.1 Data sources and years of data collection. 22 5.2 Estimates of volumes of consumption of J01 anti-infective agents. 22 5.3 Relative consumption of J01 anti-infective agents by subgroup. 24 5.4 Relative consumption by choice of agent. 27 5.5 The 10 most consumed agents . 30 5.6 Comments. 31 6. Azerbaijan . 32 6.1 Data sources and years of data collection. 32 6.2 Estimates of volumes of consumption of J01 anti-infective agents. 32 6.3 Relative consumption of J01 anti-infective agents by subgroup. 34 6.4 Relative consumption by choice of agent. 36 iii 6.5 The 10 most consumed agents . 39 6.6 Comments. 41 7. Belarus . 42 7.1 Data sources and years of data collection. 42 7.2 Estimates of volumes of consumption of J01 anti-infective agents. 42 7.3 Relative consumption of J01 anti-infective agents by subgroup. 44 7.4 Relative consumption by choice of agent. 46 7.5 The 10 most consumed agents . 50 7.6 Comments. 51 8. Kyrgyzstan. 52 8.1 Data sources and years of data collection. 52 8.2 Estimates of volumes of consumption of J01 anti-infective agents. 52 8.3 Relative consumption of J01 anti-infective agents by subgroup. 55 8.4 Relative consumption by choice of agent. 57 8.5 The 10 most consumed agents . 60 8.6 Comments. 61 9. Montenegro . 62 9.1 Data sources and years of data collection. 62 9.2 Estimates of volumes of consumption of J01 anti-infective agents. 62 9.3 Relative consumption of J01 anti-infective agents by subgroup. 64 9.4 Relative consumption by choice of agent. 66 9.5 The 10 most consumed agents . 69 9.6 Comments. 71 10. Republic of Moldova . 72 10.1 Data sources and years of data collection. 72 10.2 Estimates of volumes of consumption of J01 anti-infective agents. 72 10.3 Relative consumption of J01 anti-infective agents by subgroup . 75 10.4 Relative consumption by choice of agent. 77 10.5 The 10 most consumed agents . 80 10.6 Comments . 81 11. Serbia . ..
Recommended publications
  • The Role of Nanobiosensors in Therapeutic Drug Monitoring
    Journal of Personalized Medicine Review Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring Vivian Garzón 1, Rosa-Helena Bustos 2 and Daniel G. Pinacho 2,* 1 PhD Biosciences Program, Universidad de La Sabana, Chía 140013, Colombia; [email protected] 2 Therapeutical Evidence Group, Clinical Pharmacology, Universidad de La Sabana, Chía 140013, Colombia; [email protected] * Correspondence: [email protected]; Tel.: +57-1-8615555 (ext. 23309) Received: 21 August 2020; Accepted: 7 September 2020; Published: 25 September 2020 Abstract: Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine. Keywords: biosensors; therapeutic drug monitoring (TDM), antibiotic; personalized medicine 1. Introduction The discovery of antibiotics (AB) ushered in a new era of progress in controlling bacterial infections in human health, agriculture, and livestock [1] However, the use of AB has been challenged due to the appearance of multi-resistant bacteria (MDR), which have increased significantly in recent years due to AB mismanagement and have become a global public health problem [2].
    [Show full text]
  • Therapeutic Alternatives for Drug-Resistant Cabapenemase- Producing Enterobacteria
    THERAPEUTIC ALTERNATIVES FOR MULTIDRUG-RESISTANT AND EXTREMELY All isolates resistant to carbapenems were evaluated Fig. 1: Susceptibility (%) of Carbapenemase-producing MDRE Fig. 3: Susceptibility (%) of VIM-producing MDRE to Alternative DRUG-RESISTANT CABAPENEMASE- for the presence of genes encoding carbapenemases to Alternative Antibiotics Antibiotics PRODUCING ENTEROBACTERIA OXA-48-like, KPC, GES, NDM, VIM, IMP and GIM. M. Almagro*, A. Kramer, B. Gross, S. Suerbaum, S. Schubert. Max Von Pettenkofer Institut, Faculty of Medicine. LMU Munich, München, Germany. RESULTS BACKROUND 44 isolates of CPE were collected: OXA-48 (n=29), VIM (n=9), NDM-1 (n=5), KPC (n=1) and GES (n=1). The increasing emergence and dissemination of carbapenem-resistant gram-negative bacilli has From the 44 CPE isolates, 26 isolates were identified reduced significantly the options for sufficient as Klebsiella pneumoniae (68% of the OXA-48 CPE), 8 Fig. 2: Susceptibility (%) of OXA-48-producing MDRE to Fig. 4: Susceptibility (%) of NDM-producing MDRE to Alternative antibiotic therapy. The genes encoding most of these as Escherichia coli, 6 as Enterobacter cloacae, 2 as Alternative Antibiotics Antibiotics carbapenemases reside on plasmids or transposons Citrobacter freundii,1 as Providencia stuartii and 1 as carrying additional resistance genes which confer Morganella morganii. multidrug resistance to the isolates. 31 isolates (70%) were causing an infection, including urinary tract infection (20%), respiratory tract MATERIALS AND METHODS infection (18%), abdominal infection (18%), bacteraemia (9%) and skin and soft tissue infection In the present study, we tested the in vitro activity of (5%). 13 isolates were believed to be colonizers. antimicrobial agents against a well-characterized c o l l e c t i o n o f c a r b a p e n e m a s e - p r o d u c i n g Isolates were classified as 32 MDRE and 13 XDRE.
    [Show full text]
  • National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): a Cross-Sectional Study
    Tropical Medicine and Infectious Disease Article National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study Joseph Sam Kanu 1,2,* , Mohammed Khogali 3, Katrina Hann 4 , Wenjing Tao 5, Shuwary Barlatt 6,7, James Komeh 6, Joy Johnson 6, Mohamed Sesay 6, Mohamed Alex Vandi 8, Hannock Tweya 9, Collins Timire 10, Onome Thomas Abiri 6,11 , Fawzi Thomas 6, Ahmed Sankoh-Hughes 12, Bailah Molleh 4, Anna Maruta 13 and Anthony D. Harries 10,14 1 National Disease Surveillance Programme, Sierra Leone National Public Health Emergency Operations Centre, Ministry of Health and Sanitation, Cockerill, Wilkinson Road, Freetown, Sierra Leone 2 Department of Community Health, Faculty of Clinical Sciences, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone 3 Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, 1211 Geneva, Switzerland; [email protected] 4 Sustainable Health Systems, Freetown, Sierra Leone; [email protected] (K.H.); [email protected] (B.M.) 5 Unit for Antibiotics and Infection Control, Public Health Agency of Sweden, Folkhalsomyndigheten, SE-171 82 Stockholm, Sweden; [email protected] 6 Pharmacy Board of Sierra Leone, Central Medical Stores, New England Ville, Freetown, Sierra Leone; [email protected] (S.B.); [email protected] (J.K.); [email protected] (J.J.); [email protected] (M.S.); [email protected] (O.T.A.); [email protected] (F.T.) Citation: Kanu, J.S.; Khogali, M.; 7 Department of Pharmaceutics and Clinical Pharmacy & Therapeutics, Faculty of Pharmaceutical Sciences, Hann, K.; Tao, W.; Barlatt, S.; Komeh, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown 0000, Sierra Leone 8 J.; Johnson, J.; Sesay, M.; Vandi, M.A.; Directorate of Health Security & Emergencies, Ministry of Health and Sanitation, Sierra Leone National Tweya, H.; et al.
    [Show full text]
  • Spectroscopic Characterization of Chloramphenicol and Tetracycline
    A tica nal eu yt c ic a a m A r a c t Trivedi et al., Pharm Anal Acta 2015, 6:7 h a P DOI: 10.4172/2153-2435.1000395 ISSN: 2153-2435 Pharmaceutica Analytica Acta Research Article Open Access Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact of Biofield Treatment Mahendra Kumar Trivedi1, Shrikant Patil1, Harish Shettigar1, Khemraj Bairwa2 and Snehasis Jana2* 1Trivedi Global Inc., 10624 S Eastern Avenue Suite A-969, Henderson, NV 89052, USA 2Trivedi Science Research Laboratory Pvt. Ltd., Hall-A, Chinar Mega Mall, Chinar Fortune City, Hoshangabad Rd., Bhopal- 462026, Madhya Pradesh, India Abstract Objective: Chloramphenicol and tetracycline are broad-spectrum antibiotics and widely used against variety of microbial infections. Nowadays, several microbes have acquired resistance to chloramphenicol and tetracycline. The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy. Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups. Results: FT-IR spectrum of treated chloramphenicol exhibited the decrease in wavenumber of NO2 from 1521 cm-1 to 1512 cm-1 and increase in wavenumber of C=O from 1681 cm-1 to 1694 cm-1 in acylamino group. It may be due to increase of conjugation effect in NO2 group, and increased force constant of C=O bond. As a result, stability of both NO2 and C=O groups might be increased in treated sample as compared to control.
    [Show full text]
  • Killing of Serratia Marcescens Biofilms with Chloramphenicol Christopher Ray, Anukul T
    Ray et al. Ann Clin Microbiol Antimicrob (2017) 16:19 DOI 10.1186/s12941-017-0192-2 Annals of Clinical Microbiology and Antimicrobials SHORT REPORT Open Access Killing of Serratia marcescens biofilms with chloramphenicol Christopher Ray, Anukul T. Shenoy, Carlos J. Orihuela and Norberto González‑Juarbe* Abstract Serratia marcescens is a Gram-negative bacterium with proven resistance to multiple antibiotics and causative of catheter-associated infections. Bacterial colonization of catheters mainly involves the formation of biofilm. The objec‑ tives of this study were to explore the susceptibility of S. marcescens biofilms to high doses of common antibiotics and non-antimicrobial agents. Biofilms formed by a clinical isolate of S. marcescens were treated with ceftriaxone, kanamy‑ cin, gentamicin, and chloramphenicol at doses corresponding to 10, 100 and 1000 times their planktonic minimum inhibitory concentration. In addition, biofilms were also treated with chemical compounds such as polysorbate-80 and ursolic acid. S. marcescens demonstrated susceptibility to ceftriaxone, kanamycin, gentamicin, and chlorampheni‑ col in its planktonic form, however, only chloramphenicol reduced both biofilm biomass and biofilm viability. Poly‑ sorbate-80 and ursolic acid had minimal to no effect on either planktonic and biofilm grown S. marcescens. Our results suggest that supratherapeutic doses of chloramphenicol can be used effectively against established S. marcescens biofilms. Keywords: Serratia marcescens, Biofilm, Antibiotics, Chloramphenicol Background addition, bacteria adhere to host’s epithelial cells through Serratia marcescens is a Gram-negative bacterium that formation of biofilm [9, 10]. The ability of S. marcescens causes infections in plants, insects, and animals, includ- to form biofilms contributes to its pathogenicity [1, 11].
    [Show full text]
  • Comparable Bioavailability and Disposition of Pefloxacin in Patients
    pharmaceutics Article Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics Jürgen B. Bulitta 1,* , Yuanyuan Jiao 1, Cornelia B. Landersdorfer 2 , Dhruvitkumar S. Sutaria 1, 1 1 3 4 5,6, Xun Tao , Eunjeong Shin , Rainer Höhl , Ulrike Holzgrabe , Ulrich Stephan y and Fritz Sörgel 5,6,* 1 Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, FL 32827, USA 2 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia 3 Institute of Clinical Hygiene, Medical Microbiology and Infectiology, Klinikum Nürnberg, Paracelsus Medical University, 90419 Nürnberg, Germany 4 Institute for Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany 5 IBMP—Institute for Biomedical and Pharmaceutical Research, 90562 Nürnberg-Heroldsberg, Germany 6 Department of Pharmacology, University of Duisburg, 47057 Essen, Germany * Correspondence: [email protected]fl.edu (J.B.B.); [email protected] (F.S.); Tel.: +1-407-313-7010 (J.B.B.); +49-911-518-290 (F.S.) Deceased. y Received: 17 May 2019; Accepted: 4 July 2019; Published: 10 July 2019 Abstract: Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally cleared quinolones. We aimed to provide the first pharmacokinetic comparison for pefloxacin as a predominantly nonrenally cleared quinolone and its two metabolites between both subject groups. Eight patients with CF (fat-free mass [FFM]: 36.3 6.9 kg, average SD) and ten healthy volunteers (FFM: 51.7 9.9 kg) received 400 mg ± ± ± pefloxacin as a 30 min intravenous infusion and orally in a randomized, two-way crossover study.
    [Show full text]
  • Comparison of Thimerosal Effectiveness in the Formulation of Eye Drops Containing Neomycin Sulfate and Chloramphenicol
    International Journal of Applied Pharmaceutics ISSN- 0975-7058 Vol 11, Issue 1, 2019 Original Article COMPARISON OF THIMEROSAL EFFECTIVENESS IN THE FORMULATION OF EYE DROPS CONTAINING NEOMYCIN SULFATE AND CHLORAMPHENICOL MARLINE ABDASSAH1, SRI AGUNG FITRI KUSUMA2* 1Departement of Pharmaceutics, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia 45363, 2Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia 45363 Email: [email protected] Received: 27 Sep 2018, Revised and Accepted: 19 Nov 2018 ABSTRACT Objective: This study was aimed to compare the preservative efficacy of thimerosal in eye drops formulation containing neomycin sulfate and chloramphenicol as the active agents. Methods: Determination of thimerosal concentration in combinations with chloramphenicol and neomycin sulfate was carried out using the agar diffusion method. Then the thimerosal ineffective and minimal concentration was formulated into eye drops, each with 0.5% neomycin sulfate and 0.5% chloramphenicol as the active ingredient. Evaluation of eye drops was carried out for 28 d, which included: visual observation, pH measurement, sterility, and effectiveness test. Results: Thimerosal at a minimum concentration of 0.001% remain to provide antibacterial activity against common eyes contaminants. Both eyes drops containing neomycin sulfate, and chloramphenicol resulted in clear solution, sterile, and stable in the pH and antibacterial potency,showed the efficacy of thimerosal’s role in eye drops at the lowest concentration. But, the thimerosal stability as a preservative agent was affected by the pH values of the eye drops solution. Therefore, the effectivity of thimerosal in chloramphenicol (pH 7.19-7.22) was better than neomycin sulfate (6.45- 6.60).
    [Show full text]
  • BD BBL™ Sabouraud Brain Heart Infusion Agar Slants with Chloramphenicol and Gentamicin, Pkg
    BBL™ Sabouraud Brain Heart Infusion Agar Slants with Chloramphenicol and Gentamicin 8806701 • Rev. 02 • April 2015 QUALITY CONTROL PROCEDURES I INTRODUCTION This medium is used in qualitative procedures for the selective isolation and cultivation of pathogenic fungi from clinical and nonclinical specimens. II PERFORMANCE TEST PROCEDURE 1. Inoculate representative samples with the cultures listed below. a. For B. dermatitidis and T. mentagrophytes inoculate directly using a 0.01 mL loopful of fungal broth culture. b. For C. albicans and E. coli inoculate using 0.01 mL of saline suspensions diluted to yield 103 – 104 CFUs. 2. Incubate tubes with loosened caps at 25 ± 2 °C for up to 7 days in an aerobic atmosphere. 3. Expected Results Organisms ATCC® Recovery *Blastomyces dermatitidis 56218 Fair to heavy growth *Candida albicans 10231 Fair to heavy growth *Trichophyton mentagrophytes 9533 Fair to heavy growth *Escherichia coli 25922 Inhibition (partial to complete) *Recommended organism strain for User Quality Control. III ADDITIONAL QUALITY CONTROL 1. Examine the tubes for signs of deterioration as described under “Product Deterioration.” 2. Visually examine representative tubes to assure that any existing physical defects will not interfere with use. 3. Determine the pH potentiometrically at room temperature for adherence to the specification of 6.8 ± 0.2. 4. Incubate uninoculated representative samples at 20 – 25 °C and 30 – 35 °C and examine after 7 days for microbial contamination. PRODUCT INFORMATION IV INTENDED USE This medium is used in qualitative procedures for the selective isolation and cultivation of pathogenic fungi from clinical and nonclinical specimens. V SUMMARY AND EXPLANATION Sabouraud Brain Heart Infusion Agar is based on the formulation of Gorman.1 The combination of Brain Heart Infusion Agar and Sabouraud Dextrose Agar in this medium improves the recovery of fungi compared with the recovery on either medium individually.
    [Show full text]
  • Paper I and II)
    Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1335 Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance LISA PRASKI ALZRIGAT ACTA UNIVERSITATIS UPSALIENSIS ISSN 1651-6206 ISBN 978-91-554-9923-5 UPPSALA urn:nbn:se:uu:diva-320580 2017 Dissertation presented at Uppsala University to be publicly examined in B22, BMC, Husargatan 3, Uppsala, Friday, 9 June 2017 at 09:00 for the degree of Doctor of Philosophy (Faculty of Medicine). The examination will be conducted in English. Faculty examiner: Professor Fernando Baquero (Departamento de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain). Abstract Praski Alzrigat, L. 2017. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1335. 48 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9923-5. The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. Resistance to ciprofloxacin, a clinically important antibiotic, almost always involves target mutations in DNA gyrase and Topoisomerase IV. Because ciprofloxacin is a substrate of the AcrAB-TolC efflux pump, mutations causing pump up-regulation are also common. Studying the role of efflux pump-regulatory mutations in the development of ciprofloxacin resistance, we found a strong bias against gene-inactivating mutations in marR and acrR in clinical isolates.
    [Show full text]
  • Chloramphenicol Gesting That Mitochondrial DNA Is Involved in the Pathogenesis of Secondary Leukemia
    Report on Carcinogens, Fourteenth Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Chloramphenicol gesting that mitochondrial DNA is involved in the pathogenesis of secondary leukemia. CAS No. 56-75-7 Cancer Studies in Experimental Animals Reasonably anticipated to be a human carcinogen No adequate studies of the carcinogenicity of chloramphenicol in First listed in the Tenth Report on Carcinogens (2002) experimental animals were identified. In male mice given chloram- phenicol by intraperitoneal injection in combination with busulfan OH Cl (the known human carcinogen 1,4-butanediol dimethanesulfonate), H CH N CH the incidence of lymphoma was significantly higher than in mice re- CH C Cl ceiving either busulfan or chloramphenicol alone (Robin et al. 1981). CH2 O O2N HO Properties Carcinogenicity Chloramphenicol is a naturally occurring antibiotic derivative of di- chloroacetic acid that is a white to grayish or yellowish-white fine Chloramphenicol is reasonably anticipated to be a human carcinogen, crystalline powder at room temperature. It is soluble in water and based on limited evidence of carcinogenicity from studies in humans. very soluble in methanol, ethanol, butanol, ethyl acetate, chloroform, and acetone. It is fairly soluble in ether, but insoluble in benzene, pe- Cancer Studies in Humans troleum ether, and vegetable oils (IARC 1990, HSDB 2009). It is stable Numerous case reports have shown leukemia to occur after medical under normal shipping and handling conditions (Akron 2009). The treatment for chloramphenicol-induced aplastic anemia, and three biologically active form of chloramphenicol is levorotatory (Cham- case reports have documented the occurrence of leukemia after chlor- bers 2001).
    [Show full text]
  • TETRACYCLINES and CHLORAMPHENICOL Protein Synthesis
    ANTIMICROBIALS INHIBITING PROTEIN SYNTHESIS AMINOGLYCOSIDES MACROLIDES TETRACYCLINES AND CHLORAMPHENICOL Protein synthesis Aminoglycosides 1. Aminoglycosides are group of natural and semi -synthetic antibiotics. They have polybasic amino groups linked glycosidically to two or more aminosugar like: sterptidine, 2-deoxy streptamine, glucosamine 2. Aminoglycosides which are derived from: Streptomyces genus are named with the suffix –mycin. While those which are derived from Micromonospora are named with the suffix –micin. Classification of Aminoglycosides 1. Systemic aminogycosides Streptomycin (Streptomyces griseus) Gentamicin (Micromonospora purpurea) Kanamycin (S. kanamyceticus) Tobramycin (S. tenebrarius) Amikacin (Semisynthetic derivative of Kanamycin) Sisomicin (Micromonospora inyoensis) Netilmicin (Semisynthetic derivative of Sisomicin) 2. Topical aminoglycosides Neomycin (S. fradiae) Framycetin (S. lavendulae) Pharmacology of Streptomycin NH H2N NH HO OH Streptidine OH NH H2N O O NH CHO L-Streptose CH3 OH O HO O HO NHCH3 N-Methyl-L- Glucosamine OH Streptomycin Biological Source It is a oldest aminoglycoside antibiotic obtained from Streptomyces griseus. Antibacterial spectrum 1. It is mostly active against gram negative bacteria like H. ducreyi, Brucella, Yersinia pestis, Francisella tularensis, Nocardia,etc. 2. It is also used against M.tuberculosis 3. Few strains of E.coli, V. cholerae, H. influenzae , Enterococci etc. are sensitive at higher concentration. Mechanism of action Aminoglycosides bind to the 16S rRNA of the 30S subunit and inhibit protein synthesis. 1. Transport of aminoglycoside through cell wall and cytoplasmic membrane. a) Diffuse across cell wall of gram negative bacteria by porin channels. b) Transport across cell membrane by carrier mediated process liked with electron transport chain 2. Binding to ribosome resulting in inhibition of protein synthesis A.
    [Show full text]
  • (ESVAC) Web-Based Sales and Animal Population
    16 July 2019 EMA/210691/2015-Rev.2 Veterinary Medicines Division European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) Sales Data and Animal Population Data Collection Protocol (version 3) Superseded by a new version Superseded Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 An agency of the European Union © European Medicines Agency, 2021. Reproduction is authorised provided the source is acknowledged. Table of content 1. Introduction ....................................................................................................................... 3 1.1. Terms of reference ........................................................................................................... 3 1.2. Approach ........................................................................................................................ 3 1.3. Target groups of the protocol and templates ......................................................................... 4 1.4. Organization of the ESVAC project ...................................................................................... 4 1.5. Web based delivery of data ................................................................................................ 5 2. ESVAC sales data ............................................................................................................... 5 2.1.
    [Show full text]