Jesper Wengel Professor, Ph.D. Nukleinsyrecentret (NAC)

Personal Data: Born 1963; Married; Five children

University Address Nucleic Acid Center Department of Physics and Chemistry University of Southern Denmark, Odense Campusvej 55 DK-5230 Odense M, Denmark Tel. +45 6550 2510 Fax. +45 6615 8780 E-mail: [email protected]

University Education Dec.1988 Cand. scient.: Odense University (Chemistry/Biology) Jan.1992 Ph.D.: Odense University: "Synthesis of 2',3'-Dideoxynucleoside Analogues with Potential Activity against HIV"

Academic Employment Oct. 1990 - Jun. Research Fellow: Department of Chemistry and Biochemistry, University of Colorado, USA 1991 Sep. 1991 - Mar. Assistant Professor: In organic chemistry at Department of Chemistry, Odense University 1994 Apr. 1994 - Sep. Associate Professor: In organic chemistry at Department of Chemistry, Odense University 1996 Oct. 1996 - Jul. Professor: In bioorganic chemistry at Department of Chemistry, University of Copenhagen 2000 Aug. 2000 - Professor: In organic chemistry at Department of Chemistry, University of Southern Denmark, Odense

Present Research

Bioorganic chemistry; Medicinal chemistry; Nucleic acid biotechnology; Nanobioscience

Publications Author or co-author of >400 research papers in peer-reviewed scientific journals. H-Index = 57; Citations > 15.200 (SCI: Wengel J*; first publication in 1989)

IPR and Innovation Inventor or co-inventor on more than ten patents and patent applications. Co-inventor of the LNA (Locked Nucleic Acid) technology that forms the basis of the business activities of the companies Exiqon A/S (~60 employees) and Santaris Pharma A/S (~70 employees). Co-founder (2006) of RiboTask ApS.

Administration and Leadership experience 1991-1992 and Member of the board, Department of Chemistry, Odense University 1996 1997-2000 Member of the board, The Danish Chemical Society: Organic Chemistry Section 1999-2000 Chairman of the board, The Danish Chemical Society: Organic Chemistry Section 1998-2000 Head and Chairman of the board, Chemical Laboratory II, Department of Chemistry, University of Copenhagen 2001-2011 Director of the Nucleic Acid Center funded by the Danish National Research Foundation 2004-2013 Member of the Steering Group for Biotechnological Research Collaboration between India and Denmark, Ministry of Science, Innovation and Higher Education 2005- Member of "Praksisudvalget", University of Southern Denmark 2006- Chairman of the board, RiboTask ApS 2006-2012 Member of the Leadership Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark 2011-2012 Chairman of the Research Strategy Board. Faculty of Science, University of Southern Denmark 2012- Director of the Biomolecular Nanoscale Engineering Center – A VKR Center of Excellence funded by the Villum Foundation 2013- Chairman, Academic Council, Faculty of Science, University of Southern Denmark 2015- Chairman, University Council, University of Southern Denmark 2016- Member of the board, Independent Research Fund Denmark Memberships of diverse boards and committees, e.g. patent committee KU; Ph.D study boards SDU, ATV boards, Carlsberg chemistry prize committee, academic and industrial advisory boards, and evaluation and employment committees

Knighted 2012 Ridder af Dannebrogsordenen (Knight of Dannebrog)

Research and Innovation Awards 1997 Bjerrum-Brøndsted-Lang Lecturer 2000 Parker-Davis Lecturer, Ohio State University 2001 The Bjerrum Chemistry Award 2002 The Lundbeck Foundation's Research Prize for Young Researchers 2002 The Danish Academy of Natural Sciences Industry Award 2004 The UCB Award for Excellence in Medicinal Chemistry 2005 Villum Kann Rasmussen Grant for Technical Research 2006 OBC Lecture Award Winner 2007 The Danish Association of Masters and PhD Research 2008 The Ib Henriksen Foundation Research Award

Elected Academy Memberships 2003- The Royal Danish Academy of Sciences and Letters 2000- The Danish Academy of Natural Sciences 2005- The Danish Academy of Technical Sciences

Teaching Awards 1995 Natural Science Teaching Award, Odense University 2000 Biochemistry Teaching Award, University of Copenhagen

Major Research Funding since 2000 ERC Advanced Grant EVOLNA – Evolution of LNA-based Aptamers (2011-2016; 2.5 mio. €) International Funds – Partner in EU projects, local PI Pharmaco-Gene (LSHB-CT-2007-037283) - Design of Targeted Gene Pharmaceutics Using Self-assembling Functional Entities (2007-2010; 0.43 mio. € share of funding) RIGHT (LSHB-CT-2004-005276) - RNA Interference Technology as Human Therapeutic Tool (2005-2008; 0.74 mio. € share of funding) NAC-DRUG (MEST-CT-2004-504018) - Nucleic Acid Based Drug Design Training Center (2004-2008; 1.65 mio. €) Public Danish Funds – Center Director and PI The Nucleic Acid Center (2001-2011; 66 mio. DKK) - A center of excellence funded by The Danish National Research Foundation Studies on naturally occurring compounds of potential use in health and agriculture (1995-1998; 4.0 mio. DKK) - A capacity-building research program between Odense University, KVL and Delhi University funded by DANIDA Novel medicines for treatment of cancer and neurological disorders (2008-2012; 5.0 mio. DKK share of funding) - A HTF platform funded by The Danish Advanced Technology Foundation Private Danish Funds – Center Director and PI The Biomolecular Nanoscale Engineering Center (2012-2022; 60 mio. DKK) – A VKR Center of Excellence funded by the Villum Foundation

Publications Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria? Pereira, S., Yao, R., Gomes, M., Jørgensen, P. T., Wengel, J., Azevedo, N. F. & Santos, R. S., apr. 2021, I: Antibiotics. 10 , 4, 12 s., 379.

Polyamine-Functionalized 2′-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA Danielsen, M. B., Christensen, N. J., Jørgensen, P. T., Jensen, K. J., Wengel, J. & Lou, C., 18. jan. 2021, I: Chemistry - A European Journal. 27, 4, s. 1416-1422

Cationic oligonucleotide derivatives and conjugates: A favorable approach for enhanced DNA and RNA targeting oligonucleotides Danielsen, M. B. & Wengel, J., 2021, I: Beilstein Journal of Organic Chemistry. 17, s. 1828-1848

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J., 4. dec. 2020, I: Molecular Therapy - Nucleic Acids. 22, s. 994-1003

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation Carreras-Badosa, G., Maslovskaja, J., Periyasamy, K., Urgard, E., Padari, K., Vaher, H., Tserel, L., Gestin, M., Kisand, K. , Arukuusk, P., Lou, C., Langel, Ü., Wengel, J., Pooga, M. & Rebane, A., dec. 2020, I: Biomaterials. 262, 120316.

Reprint of “Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)- electrode surfaces” Zeng, D., Salvatore, P., Karlsen, K. K., Zhang, J., Wengel, J. & Ulstrup, J., 1. sep. 2020, I: Journal of Electroanalytical Chemistry. 872, 9 s., 114527.

Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives Matta, A., Sharma, A. K., Tomar, S., Cao, P., Kumar, S., Balwani, S., Ghosh, B., Prasad, A. K., Van Der Eycken, E. V., Depass, A. L., Wengel, J., Parmar, V. S., Len, C. & Singh, B. K., 28. aug. 2020, I: New Journal of Chemistry. 44, 32, s. 13716-13727

Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces Zeng, D., Salvatore, P., Karlsen, K. K., Zhang, J., Wengel, J. & Ulstrup, J., 15. maj 2020, I: Journal of Electroanalytical Chemistry. 865, 9 s., 114138.

Self-Assembly of DNA–Peptide Supermolecules: Coiled-Coil Peptide Structures Templated by d-DNA and l-DNA Triplexes Exhibit Chirality-Independent but Orientation-Dependent Stabilizing Cooperativity Lou, C., Boesen, J. T., Christensen, N. J., Sørensen, K. K., Thulstrup, P. W., Pedersen, M. N., Giralt, E., Jensen, K. J. & Wengel, J., 4. apr. 2020, I: Chemistry - A European Journal. 26, 25, s. 5676-5684

Adamts-Targeting Gapmers as a Gene Modulation Strategy in Osteoarthritis Garcia, J., Wengel, J., Howard, K. A. & Creemers, L. B., apr. 2020, I: Osteoarthritis and Cartilage. 28, 1, s. S521-S522

Systemic Evaluation of Chimeric LNA/2′-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy Christou, M., Wengel, J., Sokratous, K., Kyriacou, K., Nikolaou, G., Phylactou, L. A. & Mastroyiannopoulos, N. P., apr. 2020, I: Nucleic Acid Therapeutics. 30, 2, s. 80-93 14 s.

Gapmer Antisense Oligonucleotides Containing 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing Danielsen, M. B., Lou, C., Lisowiec-Wachnicka, J., Pasternak, A., Jørgensen, P. T. & Wengel, J., 27. jan. 2020, I: Chemistry - A European Journal. 26, 6, s. 1368-1379 12 s.

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages Duschmalé, J., Hansen, H. F., Duschmalé, M., Koller, E., Albaek, N., Møller, M. R., Jensen, K., Koch, T., Wengel, J. & Bleicher, K., 10. jan. 2020, I: Nucleic acids research. 48, 1, s. 63-74 12 s.

Albumin-binding fatty acid–modified gapmer antisense oligonucleotides for modulation of pharmacokinetics Cai, Y., Lou, C., Wengel, J. & Howard, K. A., 2020, Gapmers: Methods and Protocols. Yokota, T. & Maruyama, R. (red.). Humana Press, s. 163-174 (Methods in Molecular Biology, Bind 2176).

Alpha-L-locked nucleic acid-modified antisense oligonucleotides induce efficient splice modulation in vitro Raguraman, P., Wang, T., Ma, L., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2020, I: International Journal of Molecular Sciences . 21, 7, 12 s., 2434.

Carbazole modified oligonucleotides: Synthesis, hybridization studies and fluorescence properties Gouda, A. S., Przypis, Ł., Walczak, K., Jørgensen, P. T. & Wengel, J., 2020, I: Organic and Biomolecular Chemistry. 18, 35, s. 6935-6948

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers Abdelrahman, A., Gouda, A. S., Jørgensen, P. T. & Wengel, J., 2020, I: Nucleosides, Nucleotides and Nucleic Acids. 39, 1-3, s. 82-96

Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides Yadav, Y., Sharma, D., Kaushik, K., Kumar, V., Jha, A., Prasad, A. K., Len, C., Malhotra, S. V., Wengel, J. & Parmar, V. S. , 30. okt. 2019, I: Molecules. 24, 21, 16 s., 3922.

Combining nucleic acid mimics and spectral imaging with fluorescence in situ hybridization for the analysis of the gastric micro-biogeography Azevedo, A. S., Teixeira, H., Ferreira, R., Figueiredo, C., Wengel, J., Almeida, C. & Azevedo, N., 1. sep. 2019, I: Helicobacter. 24, Suppl. 1, s. 21 1 s., W6.2.

Inhibition of miR-29a and miR-146a accelerates the wound closure in a mouse model of type 1 diabetes Petkovic, M., Leal, E. C., Sorensen, A. E., Ottesen, J. T., Jorgensen, P. T., Wengel, J., Carvalho, E. & Dalgaard, L. T., 1. sep. 2019, I: Diabetologia. 62, Suppl. I, s. S53 1 s.

Molecular determinants for agonist recognition and discrimination in P2X2 receptors Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. jul. 2019, I: Journal of General Physiology. 151, 7, s. 898-911 14 s. microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. apr. 2019, I: Scientific Reports. 9, 11 s., 5836.

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. mar. 2019, I: Journal of Medicinal Chemistry. 62, 5, s. 2499- 2507

Oligonucleotide binding to non-B-DNA in MYC Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12. mar. 2019, I: Molecules. 24, 5, 11 s., 1000.

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. jan. 2019, I: Journal of Controlled Release. 294, s. 247-258

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, I: Theranostics. 9, 9, s. 2662-2677

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study Xu, Y., Gissberg, O., Pabon-Martinez, Y. V., Wengel, J., Lundin, K. E., Smith, C. I. E., Zain, R., Nilsson, L. & Villa, A., 2019, I: PLOS ONE. 14, 2, 14 s., e0211651.

Peptide-Oligonucleotide Conjugates as Nanoscale Building Blocks Boesen, J., Sorensen, K., Lou, C., Wengel, J. & Jensen, K. J., 1. sep. 2018, I: Journal of Peptide Science. 24, Suppl. 2, s. S157 1 s.

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 12. jul. 2018, I: Chemical Communications. 54, 57, s. 8003- 8006

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides Lima, J. F., Carvalho, J., Pinto-Ribeiro, I., Almeida, C., Wengel, J., Cerqueira, L., Figueiredo, C., Oliveira, C. & Azevedo, N. F., 7. jun. 2018, I: BMC Molecular Biology. 19, 13 s., 6.

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis Garcia, J., Stein, J., Cai, Y., Wexselblatt, E., Creemers, L., Wengel, J., Howard, K., Saris, D. & Yayon, A., 1. apr. 2018, I: Osteoarthritis and Cartilage. 26, Suppl. 1, s. S145

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, I: Molecular Therapy - Nucleic Acids. 11, s. 393-406

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, I: RNA Biology. 15, 10, s. 1273-1285

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, I: Organic & Biomolecular Chemistry. 16, 8, s. 1312-1321

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity Cai, Y., Makarova, A-M., Wengel, J. & Howard, K. A., 2018, I: Journal of Gene Medicine. 20, 7-8, s. 1-6

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA Ejlersen, M., Christensen, N. J., Sørensen, K. K., Jensen, K. J., Wengel, J. & Lou, C., 2018, I: Bioconjugate Chemistry. 29 , 4, s. 1025–1029

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative Kotkowiak, W., Lisowiec-Wachnicka, J., Grynda, J., Kierzek, R., Wengel, J. & Pasternak, A., 2018, I: Molecular Therapy - Nucleic Acids. 10, s. 304-316

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens Le, B. T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2018, I: RSC Advances. 8, 57, s. 32770-32774

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes Ejlersen, M., Langkjær, N. & Wengel, J., 2017, I: Organic & Biomolecular Chemistry. 15, 9, s. 2073-2085

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis Cai, Y., López-Ruiz, E., Wengel, J., Creemers, L. B. & Howard, K. A., 2017, I: Journal of controlled release : official journal of the Controlled Release Society. 253, s. 153-159

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J. S., Sohn, E., Bienk, K., Schaffert, D., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. A., 2017, I: Molecular Therapy - Nucleic Acids. 9, s. 284-293

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression Zaghloul, E. M., Gissberg, O., Moreno, P. M. D., Siggens, L., Hällbrink, M., Jørgensen, A. S., Ekwall, K., Zain, R., Wengel, J., Lundin, K. E. & Smith, C. I. E., 2017, I: Nucleic Acids Research. 45, 9, s. 5153-5169

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule Aaldering, L. J., Poongavanam, V., Langkjær, N., Murugan, N. A., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2017, I: ChemBioChem. 18, 8, s. 755–763

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J. S., Wengel, J., Kjems, J. & Howard, K. A., 2017, I: Molecular Therapy. 25, 7, s. 1710-1717

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex Lou, C., Christensen, N. J., Martos-Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, P. W., Sørensen, K. K., Jensen, K. J. & Wengel, J., 2017, I: Chemistry: A European Journal. 23, 39, s. 9297–9305

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures Pabon-Martinez, Y. V., Xu, Y., Villa, A., Lundin, K. E., Geny, S., Nguyen, C-H., Pedersen, E. B., Jørgensen, P. T., Wengel, J., Nilsson, L., Smith, C. I. E. & Zain, R., 2017, I: Scientific Reports. 7, 1, 16 s., 11043.

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers Kristensen, K. V., Paul, S., Kosbar, T., Wengel, J. & Caruthers, M. H., 2017, I: Bioorganic & Medicinal Chemistry Letters. 27, 14, s. 3173–3176

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA Lou, C., Samuelsen, S. V., Christensen, N. J., Vester, B. & Wengel, J., 2017, I: Bioconjugate Chemistry. 28, 4, s. 1214- 1220

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies Hartono, Y. D., Pabon-Martinez, Y. V., Uyar, A., Wengel, J., Lundin, K. E., Zain, R., Smith, C. I. E., Nilsson, L. & Villa, A., 2017, I: ACS Omega. 2, 5, s. 2165-2177 13 s.

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J., Sørensen, E. S., Wengel, J. & Howard, K. A., 2017 , I: Nanotechnology. 28, 20, 9 s., 204004.

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units Kumar, R., Ries, A. & Wengel, J., 2017, I: Molecules. 22, 5, 13 s., 852.

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers Ries, A., Kumar, R., Lou, C., Kosbar, T., Vengut-Climent, E., Jørgensen, P. T., Morales, J. C. & Wengel, J., 13. okt. 2016, I: The Journal of Organic Chemistry. 81, 22, s. 10845-10856

Evaluation of nucleolin and somatostatin receptor targeting for therapeutic delivery to lung cancer stem cells Hansen, P. L., Holmboe, S., Olsen, B. B., Thisgaard, H., Christiansen, H., Schmidt, S., Block, I., Müller, C., Langkjær, N., Jørgensen, P. T., Vogel, S., Wengel, J., Høilund-Carlsen, P. F. & Mollenhauer, J., 27. jun. 2016.

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes Geny, S., Moreno, P. M. D., Krzywkowski, T., Gissberg, O., Andersen, N. K., Isse, A. J., El-Madani, A. M., Lou, C., Pabon, Y. V., Anderson, B. A., Zaghloul, E. M., Zain, R., Hrdlicka, P. J., Jørgensen, P. T., Nilsson, M., Lundin, K. E., Pedersen, E. B., Wengel, J. & Smith, C. I. E., 18. mar. 2016, I: Nucleic Acids Research. 44, 5, s. 2007-2019

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M., Kragh-Hansen, U., Cameron, J., Bukrinski, J. T. & Howard, K. A., 2016, I: Journal of Controlled Release. 232, s. 143-151

Application of locked nucleic acid-based probes in fluorescence in situ hybridization Fontenete, S., Carvalho, D. R., Guimarães, N., Madureira, P., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2016, I: Applied Microbiology and Biotechnology. 100, 13, s. 5897-5906

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs Gissberg, O., Zaghloul, E. M., Lundin, K. E., Nguyen, C-H., Landras-Guetta, C., Wengel, J., Zain, R. & Smith, C. I. E., 2016, I: Nucleic Acid Therapeutics. 26, 3, s. 183-189

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model Fontenete, S., Leite, M., Cappoen, D., Santos, R., Ginneken, C. V., Figueiredo, C., Wengel, J., Cos, P. & Azevedo, N. F., 2016, I: P L o S One. 11, 2, 18 s., e0148353.

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J., 2016, I: Nature Communications. 7, s. 1-9 12294.

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models Fontenete, S., Guimarães, N., Wengel, J. & Azevedo, N. F., 2016, I: Critical Reviews in Biotechnology. 36, 3, s. 566-577

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori Santos, R. S., Dakwar, G. R., Xiong, R., Forier, K., Remaut, K., Stremersch, S., Guimarães, N., Fontenete, S., Wengel, J. , Leite, M., Figueiredo, C., De Smedt, S. C., Braeckmans, K. & Azevedo, N. F., 10. dec. 2015, I: Molecular Therapy - Nucleic Acids. 4, s. e269 9 s.

Watson-Crick hydrogen bonding of unlocked nucleic acids Langkjær, N., Wengel, J. & Pasternak, A., 15. nov. 2015, I: Bioorganic & Medicinal Chemistry Letters. 25, 22, s. 5064- 5066 3 s.

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. maj 2015, I: Chemical Communications. 51, 46, s. 9499-9502

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids Fontenete, S., Joana, B., Pedro, M., Céu, F., Wengel, J. & Filipe, A. N., maj 2015, I: Applied Microbiology and Biotechnology. 99, 9, s. 3961-3969

Selection of LNA-containing DNA aptamers against recombinant human CD73 Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. apr. 2015, I: Molecular BioSystems. 11, 5, s. 1260-1270

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance Lou, C., Vester, B. & Wengel, J., 9. feb. 2015, I: Chemical Communications. 51, 19, s. 4024-4027

Detection and discrimination of biofilm populations using locked nucleic acid/2'-O-methyl-RNA fluorescence in situ hybridization (LNA/2'OMe-FISH) Azevedo, A. S., Almeida, C., Pereira, B., Madureira, P., Wengel, J. & Azevedo, N. F., 2015, I: Biochemical Engineering Journal. 104, 15 December, s. 64-73 10 s.

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer Opazo, F., Eiden, L., Hansen, L., Rohrbach, F., Wengel, J., Kjems, J. & Mayer, G., 2015, I: Molecular Therapy - Nucleic Acids. 4, 10 s., e251.

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes Fontenete, S., Leite, M., Guimarães, N., Madureira, P., Ferreira, R. M., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2015 , I: PLOS ONE. 10, 4, s. e0125494 22 s.

Brightness through Local Constraint-LNA-Enhanced FIT Hybridization Probes for In Vivo Ribonucleotide Particle Tracking Hövelmann, F., Gaspar, I., Loibl, S., Ermilov, E. A., Röder, B., Wengel, J., Ephrussi, A. & Seitz, O., 13. okt. 2014, I: Angewandte Chemie International Edition. 53, 42, s. 11370-11375 6 s.

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model Bestas, B., Moreno, P. M. D., Blomberg, K. E. M., Mohammad, D. K., Saleh, A. F., Sutlu, T., Nordin, J. Z., Guterstam, P., Gustafsson, M. O., Kharazi, S., Piątosa, B., Roberts, T. C., Behlke, M. A., Wood, M. J. A., Gait, M. J., Lundin, K. E., El Andaloussi, S., Månsson, R., Berglöf, A., Wengel, J. & 1 flere, Smith, C. I. E., 2. sep. 2014, I: Journal of Clinical Investigation. 124, 9, s. 4067-4081 15 s.

Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties Perlíková, P., Ejlersen, M., Langkjaer, N. & Wengel, J., sep. 2014, I: ChemMedChem. 9, 9, s. 2120-2127 8 s.

Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues Xu, L., Butler, K. V., Chong, J., Wengel, J., Kool, E. T. & Wang, D., 1. maj 2014, I: Nucleic Acids Research. 42, 9, s. 5863- 5870 8 s.

Scaffolding along Nucleic Acid Duplexes Using 2'-Amino-Locked Nucleic Acids Astakhova, I. K. & Wengel, J., 21. apr. 2014, I: Accounts of Chemical Research. 47, 6, s. 1768-1777 10 s.

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions Jørgensen, A. S., Hansen, L. H., Vester, B. & Wengel, J., 3. apr. 2014, I: Bioorganic & Medicinal Chemistry Letters. 24, 10 , s. 2273–2277 5 s.

By-Product Formation in Repetitive PCR Amplification of DNA Libraries during SELEX Tolle, F., Wilke, J., Wengel, J. & Mayer, G., 2014, I: PLOS ONE. 9, 12, s. e114693 12 s.

Functionalization of 2’’-C-(piperazinomethyl)-2’,3’-BcNA (bicyclic nucleic acids) with pyren-1-ylcarbonyl units Hansen, M. B., Andersen, N. K., Raunkjær, M., Jørgensen, P. T. & Wengel, J., 2014, I: Helvetica Chimica Acta. 97, 9, s. 1204-1218 15 s.

Multifunctional Nucleic Acids for Tumor Cell Treatment Pofahl, M., Wengel, J. & Mayer, G., 2014, I: Nucleic Acid Therapeutics. 24, 2, s. 171-177

Unlocked nucleic acids with a pyrene-modified uracil: Synthesis, hybridization studies, fluorescent properties and i-motif stability Perlíková, P., Karlsen, K. K., Pedersen, E. B. & Wengel, J., 2014, I: ChemBioChem. 15, 1, s. 146-156

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold Marusic, M., Veedu, R. N., Wengel, J. & Plavec, J., nov. 2013, I: Nucleic Acids Research. 41, 20, s. 9524-9536 13 s.

Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA Sau, S. P., Madsen, A. S., Podbevsek, P., Andersen, N. K., Kumar, T. S., Andersen, S., Rathje, R. L., Anderson, B. A., Guenther, D. C., Karmakar, S., Kumar, P., Plavec, J., Wengel, J. & Hrdlicka, P. J., 25. sep. 2013, I: Journal of Organic Chemistry. 78, 19, s. 9560-9570 11 s.

A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid) Karlsen, K. K., Okholm, A. H., Kjems, J. & Wengel, J., 1. maj 2013, I: Bioorganic & Medicinal Chemistry. 21, 20, s. 6186- 6190 5 s.

"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies Jørgensen, A. S., Gupta, P., Wengel, J. & Astakhova, I. K., 2013, I: Chemical Communications. 49, 91, s. 10751-10753

A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids Xu, L., Plouffe, S. W., Chong, J., Wengel, J. & Wang, D., 2013, I: Angewandte Chemie International Edition. 52, 47, s. 12341-12345

A locked nucleic Acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence Astakhova, I. K., Pasternak, K., Campbell, M. A., Gupta, P. & Wengel, J., 2013, I: Journal of the American Chemical Society. 135, 7, s. 2423-2426 4 s.

Biological activity and biotechnological aspects of locked nucleic acids Lundin, K. E., Højland, T., Hansen, B. R., Persson, R., Bramsen, J. B., Kjems, J., Koch, T., Wengel, J. & Smith, C. I. E., 2013, I: Advances in Genetics. 82, s. 47-107 61 s.

Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3′-end ribonucleotidic strand Barbeyron, R., Vasseur, J-J., Smietana, M. & Wengel, J., 2013, I: Monatshefte fuer Chemie. 144, 4, s. 495-500 6 s.

Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2'-α-l-amino-LNA FRET pairs Astakhova, I. K., Santhosh Kumar, T., Campbell, M. A., Ustinov, A. V., Korshun, V. A. & Wengel, J., 2013, I: Chemical Communications. 49, 5, s. 511-513 3 s.

Chemical fidelity of an RNA polymerase ribozyme Attwater, J., Tagami, S., Kimoto, M., Butler, K., Kool, E. T., Wengel, J., Herdewijn, P., Hirao, I. & Holliger, P., 2013, I: Chemical Science. 4, 7, s. 2804-2814

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA Moreno, P. M. D., Geny, S., Pabon, Y. V., Bergquist, H., Zaghloul, E. M., Rocha, C. S. J., Oprea, I. I., Bestas, B., Andaloussi, S. E., Jørgensen, P. T., Pedersen, E. B., Lundin, K. E., Zain, R., Wengel, J. & Smith, C. I. E., 2013, I: Nucleic Acids Research. 41, 5, s. 3257-3273 17 s.

Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces Hansen, A. G., Salvatore, P., Karlsen, K. K., Nichols, R. J., Wengel, J. & Ulstrup, J., 2013, I: Physical Chemistry Chemical Physics. 15, 3, s. 776-786 11 s.

Electrochemistry of Single Metalloprotein and DNA-Based Molecules at Au(111) Electrode Surfaces Salvatore, P., Zeng, D., Karlsen, K. K., Chi, Q., Wengel, J. & Ulstrup, J., 2013, I: ChemPhysChem. 14, 10, s. 2101-2111

Hybridization-Based Detection of Helicobacter pylori at Human Body Temperature Using Advanced Locked Nucleic Acid (LNA) Probes Fontenete, S., Guimarães, N., Leite, M., Figueiredo, C., Wengel, J. & Filipe Azevedo, N., 2013, I: PLOS ONE. 8, 11, 11 s. , e81230.

Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes Astakhova, I. K. & Wengel, J., 2013, I: Chemistry: A European Journal. 19, 3, s. 1112-1122 11 s.

Peptide-LNA oligonucleotide conjugates Astakhova, I. K., Hansen, L. H., Vester, B. & Wengel, J., 2013, I: Organic & Biomolecular Chemistry. 11, 25, s. 4240-4249

Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2'-Amino-α-l-LNA Adenine Monomers: High- Affinity Targeting of Single-Stranded DNA Andersen, N. K., Anderson, B. A., Wengel, J. & Hrdlicka, P. J., 2013, I: Journal of Organic Chemistry. 78, 24, s. 12690- 12702

Amplification and Re-Generation of LNA-Modified Libraries Doessing, H., Hansen, L. H., Veedu, R. N., Wengel, J. & Vester, B., 2012, I: Molecules. 17, 11, s. 13087-13097

Cleavage and protection of locked nucleic acid-modified DNA by restriction endonucleases Crouzier, L., Dubois, C., Wengel, J. & Veedu, R. N., 2012, I: Bioorganic & Medicinal Chemistry Letters. 22, 14, s. 4836- 4838 3 s.

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers Crouzier, L., Dubois, C., Edwards, S. L., Lauridsen, L. H., Wengel, J. & Veedu, R. N., 2012, I: P L o S One. 7, 4, s. e35990 5 s.

Enzymatic polymerisation involving 2'-amino-LNA nucleotides Johannsen, M. W., Veedu, R. N., Madsen, A. S. & Wengel, J., 2012, I: Bioorganic & Medicinal Chemistry Letters. 22, 10, s. 3522-3526 5 s.

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides Højland, T., Veedu, R. N., Vester, B. & Wengel, J., 2012, I: Artificial DNA, PNA & XNA. 3, 1, s. 14-21 8 s.

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important Schyth, B. D., Bramsen, J. B., Pakula, M. M., Larashati, S., Kjems, J., Wengel, J. & Lorenzen, N., 2012, I: Nucleic Acids Research. 40, 10, s. 4653-65 13 s.

Large Scale Synthesis of 2'-Amino-LNA Thymine and 5-Methylcytosine Nucleosides Madsen, A. S., Jørgensen, A. S., Jensen, T. B. & Wengel, J., 2012, I: Journal of Organic Chemistry. 77, 23, s. 10718-28 11 s.

Locked Nucleic Acid and Aptamers Karlsen, K. K. & Wengel, J., 2012, I: Nucleic Acid Therapeutics. 22, 6, s. 366-70 5 s.

Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications Veedu, R. N. & Wengel, J., 2012, Chemistry and Biology of Artificial Nucleic Acids . Egli, M. & Herdewijn, P. (red.). Zürich: Wiley-VCH, s. 159-165 7 s.

Modulating anti-MicroRNA-21 activity and specificity using oligonucleotide derivatives and length optimization Munoz-Alarcon, A., Guterstam, P., Romero, C., Behlke, M. A., Lennox, K. A., Wengel, J., EL Andaloussi, S. & Langel, U., 2012, I: ISRN Pharmaceutics . 2012, ID 407154, s. 1-7 7 s.

Novel (Phenylethynyl)pyrene-LNA Constructs for Fluorescence SNP Sensing in Polymorphic Nucleic Acid Targets Astakhova, I. K., Samokhina, E., Babu, B. R. & Wengel, J., 2012, I: ChemBioChem. 13, 10, s. 1509-19 11 s.

Oligonucleotides with 1,4-dioxane-based nucleotide monomers Madsen, A. S. & Wengel, J., 2012, I: Journal of Organic Chemistry. 77, 8, s. 3878-86 9 s.

Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking Wenge, U., Wengel, J. & Wagenknecht, H-A., 2012, I: Angewandte Chemie International Edition. 51, 40, s. 10026-10029 4 s.

Pyrene-modified unlocked nucleic acids: synthesis, thermodynamic studies, and fluorescent properties Karlsen, K. K., Pasternak, A., Jensen, T. B. & Wengel, J., 2012, I: ChemBioChem. 13, 4, s. 590-601 12 s.

Selective Biocatalytic Acylation Studies on 5'-O-(4,4'-Dimethoxytrityl)-2',3'-Secouridine: An Efficient Synthesis of UNA Monomer Singh, S. K., Reddy, L. C., Srivastava, S., Olsen, C. E., Sanghvi, Y. S., Langkjær, N., Wengel, J., Parmar, V. S. & Prasad, A. K., 2012, I: Nucleosides, Nucleotides and Nucleic Acids. 31, 12, s. 831-40 10 s.

Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides Dubois, C., Campbell, M. A., Edwards, S. L., Wengel, J. & Veedu, R. N., 2012, I: Chemical Communications. 48, 44, s. 5503-5505 3 s.

Synthetic genetic polymers capable of heredity and evolution Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S- Y., McLaughlin, S. H., Herdewijn, P. & Holliger, P., 2012, I: Science. 336, 6079, s. 341-4 4 s.

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals Campbell, M. A. & Wengel, J., 14. dec. 2011, I: Chemical Society Reviews. 40, 12, s. 5680-5689 10 s.

Synthesis of 2'-AMINO-UNA Langkjær, N. & Wengel, J., 17. okt. 2011. 1 s.

Unlocked nucleic acid - an RNA modification with broad potential Pasternak, A. & Wengel, J., 21. maj 2011, I: Organic & Biomolecular Chemistry. 9, 10, s. 3591-7 7 s.

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA Zaghloul, E. M., Madsen, A. S., Moreno, P. M. D., Oprea, I. I., El-Andaloussi, S., Bestas, B., Gupta, P., Pedersen, E. B., Lundin, K. E., Wengel, J. & Smith, C. I. E., 1. feb. 2011, I: Nucleic Acids Research. 39, 3, s. 1142-54 13 s.

Minimal Substrate Features for Erm Methyltransferases Defined by Using a Combinatorial Oligonucleotide Library Hansen, L. H., Lobedanz, S., Douthwaite, S., Arar, K., Wengel, J., Kirpekar, F. & Vester, B., 24. jan. 2011, I: ChemBioChem. 12, 4, s. 610-614 5 s.

Amino acids attached to 2'-amino-LNA: synthesis and excellent duplex stability Johannsen, M. W., Crispino, L., Wamberg, M. C., Kalra, N. & Wengel, J., 7. jan. 2011, I: Organic & Biomolecular Chemistry. 9, 1, s. 243-252 10 s.

Fluorescent oligonucleotides containing a novel perylene 2′-amino-α-L-LNA monomer: Synthesis and analytical potential Astakhova, I., Kumar, S. T. & Wengel, J., 2011, I: Collection of Czechoslovak Chemical Communications. 76, 11, s. 1347- 1360

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer Pasternak, A., Hernandez, F. J., Rasmussen, L. M., Vester, B. & Wengel, J., 2011, I: Nucleic Acids Research. 39, 3, s. 1155-1164

LNA for Optimization of Fluorescent Oligonucleotide Probes: Improved Spectral Properties and Target Binding Astakhova, I. V., Ustinov, A. V., Korshun, V. A. & Wengel, J., 2011, I: Bioconjugate Chemistry. 22, 4, s. 533-9 7 s.

Locked nucleic acid oligonucleotides toward clinical applications Veedu, R. N. & Wengel, J., 2011, Medicinal Chemistry of Nucleic Acids. Zhang, L-H., Xi, Z. & Chattopadhyaya, J. (red.). Hoboken, N. J.: John Wiley & Sons Ltd, s. 335-348 13 s.

Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers Pasternak, A. & Wengel, J., 2011, I: Bioorganic & Medicinal Chemistry Letters. 21, 2, s. 752–755 4 s.

Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers Pasternak, K., Pasternak, A., Gupta, P., Veedu, R. N. & Wengel, J., 2011, I: Bioorganic & Medicinal Chemistry Letters. 19 , 24, s. 7407-15 9 s.

Synthesis and Structural Characterization of 2'-Fluoro-α-L-RNA-Modified Oligonucleotides Bundgaard Jensen, T., Pasternak, A., Stahl Madsen, A., Petersen, M. & Wengel, J., 2011, I: ChemBioChem. 12, 12, s. 1904-11 8 s.

Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA Skov, J., Bryld, T., Lindegaard, D., Nielsen, K. E., Højland, T., Wengel, J. & Petersen, M., 2011, I: Nucleic Acids Research. 39, 5, s. 1953-65 13 s.

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer Jensen, T. B., Henriksen, J. R., Rasmussen, L. B., Rasmussen, L. M., Andresen, T. L., Wengel, J. & Pasternak, A., 2011, I: Bioorganic & Medicinal Chemistry. 19, 16, s. 4739-45 7 s.

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids Veedu, R. N., Burri, H. V. R., Kumar, P., Sharma, P. K., Hrdlicka, P. J., Vester, B. & Wengel, J., 15. nov. 2010, I: Bioorganic & Medicinal Chemistry Letters. 20, 22, s. 6565-8 4 s.

Biocatalytic Separation of N-7/N-9 Guanine Nucleosides Singh, S. K., Sharma, V. K., Olsen, C. E., Wengel, J., Parmar, V. S. & Prasad, A. K., 25. okt. 2010, I: Journal of Organic Chemistry. 75, 22, s. 7932-7935 4 s.

Red universitetet! Mouritsen, O. G. & Wengel, J., 21. okt. 2010, I: Information. s. 14

David versus Goliath Mollenhauer, J., Stamou, D., Flyvbjerg, A., Wengel, J., Gether, U., Kjems, J., Bjørnholm, T. & Besenbacher, F., aug. 2010 , I: Nanomedicine. 6, 4, s. 504-509 6 s.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off- target effects Bramsen, J. B., Pakula, M. M., Hansen, T. B., Bus, C., Langkjær, N., Odadzic, D., Smicius, R., Wengel, S. L., Chattopadhyaya, J., Engels, J. W., Herdewijn, P., Wengel, J. & Kjems, J., 2010, I: Nucleic Acids Research. 38, 17, s. 5761-5773

Amino acids attached to 2'-amino-LNA: Synthesis of DNA mixmer oligonucleotides with increased duplex stability Johannsen, M. W., Wengel, J., Wamberg, M. C., Crispino, L. & Kalra, N., 2010. 1 s.

Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3 Werk, D., Wengel, J., Wengel, S. L., Grunert, H-P., Zeichhardt, H. & Kurreck, J., 2010, I: FEBS Letters. 584, 3, s. 591-598 8 s.

LNA 5'-phosphoramidites for 5'→3'-oligonucleotide synthesis Madsen, A. S., Kumar, S. T. & Wengel, J., 2010, I: Organic & Biomolecular Chemistry. 8, 21, s. 5012 5016 s.

Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications Veedu, R. N. & Wengel, J., 2010, I: Chemistry & Biodiversity. 7, 3, s. 536-542 7 s.

Novel insights into the use of glowing LNA as nucleic acid detection probes-Influence of labeling density and nucleobases. Østergaard, M. E., Maity, J., Babu, B. R., Wengel, J. & Hrdlicka, P. J., 2010, I: Bioorganic & Medicinal Chemistry Letters. 20, 24, s. 7265-7268

Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing Astakhova, I., Lindegaard, D., Korshun, V. A. & Wengel, J., 2010, I: Chemical Communications. 46, 44, s. 8362-8364

Polymerase directed incorporation studies of LNA-G nucleoside 5'-triphosphate and primer extension involving all four LNA nucleotides Veedu, R. N., Vester, B. & Wengel, J., 2010, I: New Journal of Chemistry. 34, 5, s. 877-879 3 s.

Synthesis and Biophysical Properties of Oligodeoxynucleotides Containing 2'-Deoxy-5-(4-nitro-1H-imidazol-1-yl)-ß-D- uridine and 2'-Deoxy-5-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-ß-D-uridine Monomers Gondela, A., Kumar, S. T., Walczak, K. & Wengel, J., 2010, I: Chemistry & Biodiversity. 7, 2, s. 350-362 13 s.

Synthesis and Biophysical Studies of Coronene Functionalized 2′-Amino-LNA: A Novel Class of Fluorescent Nucleic Acids Gupta, P., Langkjær, N. & Wengel, J., 2010, I: Bioconjugate Chemistry. 21, 3, s. 513-520 8 s.

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides Pasternak, A. & Wengel, J., 2010, I: Nucleic Acids Research. 38, 19, s. 6697-6706

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo Laursen, M. B., Pakula, M. M., Gao, S., Fluiter, K., Mook, O. R., Baas, F., Langkjær, N., Wengel, S. L., Wengel, J., Kjems, J. & Bramsen, J. B., 2010, I: Molecular BioSystems. 6, s. 862-870 9 s.

Synthesis and regioselective deacylation studies on peracylated 2′-azido arabino- and ribo-thymine nucleosides: Towards 5′-O,2′-N-linked oligonucleotides Sharma, D., Khandelwal, A., Bhatia, S., Reddy, L. C., Wengel, J., Olsen, C. E., Parmar, V. S. & Prasad, A. K., 1. jan. 2009 , I: Indian journal of chemistry. Section B: Organic chemistry, including medical chemistry. 48B, 12, s. 1712-1720 9 s.

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjær, N., Babu, B. R., Hojland, T., Abramov, M., Van Aerschot, A., Odadzic, D., Smicius, R., Haas, J., Andree, C., Barman, J., Wenska, M., Srivastava, P., Zhou, C., Honcharenko, D., Hess, S. & 11 flere, Hess, S., Bobkov, G. V., Mikhailov, S. N., Fava, E., Meyer, T. F., Chattopadhyaya, J., Zerial, M., Engels, J. W., Herdewijn, P., Wengel, J. & Kjems, J., 2009, I: Nucleic Acids Research. 37, 9, s. 2867-2881 15 s.

Aptamers as a model for functional evaluation of LNA and 2'-amino LNA Hernandez, F. J., Kalra, N., Wengel, J. & Vester, B., 2009, I: Bioorganic & Medicinal Chemistry Letters. 19, 23, s. 6585- 6587 3 s.

C4'-substituted - DNA nucleotide gapmer oligonucleotides Wengel, J., 2009, Patentnr. WO2009090182

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase Veedu, R. N., Vester, B. & Wengel, J., 2009, I: Organic & Biomolecular Chemistry. 7, 7, s. 1404-1409 6 s.

Enzymatic incorporation of LNA nucleotides Wengel, J., Vester, B. & Veedu, R. N., 2009, Patentnr. WO2009039862

Expanding the applications of locked nucleic acids Veedu, R. N. & Wengel, J., 2009, I: Indian journal of chemistry. Section B: Organic chemistry, including medical chemistry. 48B, 12, s. 1709-1711 3 s.

Filling the gap in LNA antisense oligo gapmers: The effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer Fluiter, K., Mook, O. R. F., Vreijling, J., Langkjær, N., Højland, T., Wengel, J. & Baas, F., 2009, I: Molecular BioSystems. 5 , 8, s. 838-843 6 s.

Functionalization of 2'-amino-LNA with additional nucleobases Umemoto, T., Wengel, J. & Madsen, A. S., 2009, I: Organic & Biomolecular Chemistry. 7, 9, s. 1793-1797 5 s.

Functionalized 2′-amino-α-L-LNA: Directed positioning of intercalators for DNA targeting Kumar, T. S., Madsen, A. S., Østergaard, M., Sau, S. P., Wengel, J. & Hrdlicka, P. J., 2009, I: Journal of Organic Chemistry. 74, 3, s. 1070-1081 12 s.

Locked nucleic acid as a novel class of therapeutic agents Veedu, R. N. & Wengel, J., 2009, I: RNA Biology. 6, 3, s. 321-323 3 s.

Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers Veedu, R. N. & Wengel, J., 2009, I: Molecular BioSystems. 5, 8, s. 787-792 6 s.

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration Glud, S. Z., Bramsen, J. B., Dagnæs-Hansen, F., Wengel, J., Howard, K. A., Nyengaard, J. R. & Kjems, J., 2009, I: Oligonucleotides. 19, 2, s. 163-168 6 s.

Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides Nagahama, K., Veedu, R. N. & Wengel, J., 2009, I: Bioorganic & Medicinal Chemistry Letters. 19, 10, s. 2707-2709 3 s.

Parallel RNA-strand recognition by 2'-amino-β-LNA Kumar, T. S., Østergaard, M. E., Sharma, P. K., Nielsen, P., Wengel, J. & Hrdlicka, P. J., 2009, I: Bioorganic & Medicinal Chemistry Letters. 19, 9, s. 2396-2399 4 s.

Synthesis and hybridization studies of α-configured arabino nucleic acids Gupta, P., Maity, J., Shakya, G., Prasad, A. K., Parmar, V. S. & Wengel, J., 2009, I: Organic & Biomolecular Chemistry. 7, 11, s. 2389-2401 13 s.

Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes Karlsen, K. K., Jensen, T. B. & Wengel, J., 2009, I: Journal of Organic Chemistry. 74, 22, s. 8838-8841 4 s.

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice Gao, S., Dagnaes-Hansen, F., Nielsen, E. J. B., Wengel, J., Besenbacher, F., Howard, K. A. & Kjems, J., 2009, I: Molecular Therapy. 17, 7, s. 1225-1233 9 s.

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability Langkjær, N., Pasternak, A. & Wengel, J., 2009, I: Bioorganic & Medicinal Chemistry. 17, 15, s. 5420-5425 6 s.

Chemically modified oligonucleotides with efficient RNase H response Vester, B., Boel, A. M., Lobedanz, S., Babu, B. R., Raunkjaer, M., Lindegaard, D., Raunak, Hrdlicka, P. J., Højland, T., Sharma, P. K., Kumar, S., Nielsen, P. & Wengel, J., 1. apr. 2008, I: Bioorganic & Medicinal Chemistry Letters. 18, 7, s. 2296-2300 4 s.

(Phenylethynyl)pyrenes attached to 2'-amino-LNA: novel fluorescent dyes with the advantages of long-wave emission, high fluorescence quantum yields and excimer formation Wengel, J., Astakhova, I. & Korshun, V. A., 2008. 4 s.

2'-N-(Pyren-1-yl)carbonyl-2'-amino-LNA (locked nucleic acid): A versatile label for nucleic acid detection Wengel, J., Østergaard, M. E. & Maity, J., 2008. 1 s.

Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3 Wengel, J., Dutkiewicz, M., Grunert, H-P., Zeichhardt, H., Lena, S. W. & Kurreck, J., 2008, I: FEBS Letters. 582, 20, s. 3061-3066

Effect of locked nucleic acid (LNA) modification on hybridization kinetics of DNA duplex Arora, A., Kaur, H., Wengel, J. & Maiti, S., 2008, I: Nucleic Acids Symposium Series. 1, s. 417-418 2 s.

Enzymatic synthesis of LNA oligonucleotides using polymerases Veedu, R. N., Vester, B. & Wengel, J., 2008, Collection Symposium Series 15, Chemistry of Nucleic Acid Components. SCNAZ, s. 254-257 3 s.

Greener biocatalytic approach to the synthesis of nucleosides and their precursors Singh, S. K., Sharma, R. K., Maity, J., Wengel, J., Parmar, V. S. & Prasad, A. K., 2008, I: Nucleic Acids Symposium Series. 52, 1, s. 273-274 2 s.

Highly fluorescent conjugated pyrenes in nucleic acid probes: (Phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids Astakhova, I., Korshun, V. A. & Wengel, J., 2008, I: Chemistry: A European Journal. 14, 35, s. 11010-11026 16 s.

Hydroxymethyl substituted RNA oligonucleotides and RNA complexes Wengel, J., 2008, Patentnr. WO 2008147824

Identification of Efficient and Sequence Specific Bimolecular Artificial Ribonucleases by a Combinatorial Approach Kalek, M., Benediktson, P., Vester, B. & Wengel, J., 2008, I: Chemical Communications. 6, s. 762-764

LNA (Locked Nucleic Acid) and functionalized LNA: toward efficient gene targeting Wengel, J., 2008, 1 udg. USA: Taylor & Francis. 5 s.

Locked nucleic acid (LNA) Wengel, J. & Müller, S. (red.), 2008, Nucleic Acids from A to Z: A Concise Encyclopedia. Wiley-VCH, s. 164-165 2 s.

Locked Nucleic Acids; Properties, Applications and Perspectives Nielsen, P. & Wengel, J., 2008, Modified Nucleosides in Biochemistry, Biotechnology and Medicine. Herdewijn, P. (red.). Wiley-VCH, s. 133-152 20 s.

Modified nucleic acids: Locked or unlocked? Wengel, J., 2008. 1 s.

N2'-Functionalized 2'-amino-alfa-L-LNA: A novel class of locked nucleic acids as emerging tools for nucleic acid therapeutics and diagnostics Wengel, J., Kumar, S. T., Madsen, A. S., Andersen, N. K. & Hrdlicka, P. J., 2008. 1 s.

New conformationally restricted DNA mimics Højland, T., Babu, B. R. & Wengel, J., 2008, I: Nucleic Acids Symposium Series. 52, 1, s. 271-272

Novel long-wave emission fluorochrome based upon perylen-3-ylcarbonyl-functionalized 2'-amino-LNA Wengel, J., Astakhova, I. & Korshun, V. A., 2008. 1 s.

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-α-L-LNA monomers and abasic sites Kumar, S. T., Madsen, A. S., Østergaard, M. E., Wengel, J. & Hrdlicka, P. J., 2008, I: Journal of Organic Chemistry. 73, 18 , s. 7060-7066 6 s.

Nucleosides with 1,4-dioxane as sugar moiety Madsen, A. S., Langkjær, N. & Wengel, J., 2008, I: Nucleic Acids Symposium Series. 52, 1, s. 269-270

Perylene attached to 2'-amino-LNA: Synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture Astakhova, I., Korshun, V. A., Jahn, K., Kjems, J. & Wengel, J., 2008, I: Bioconjugate Chemistry. 19, 10, s. 1995-2007 12 s.

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates Veedu, R. N., Vester, B. & Wengel, J., 2008, I: Journal of the American Chemical Society. 130, 26, s. 8124-8125 2 s.

Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA Lindegaard, D., Madsen, A. S., Astakhova, I. V., Malakhov, A. D., Babu, B. R., Korshun, V. A. & Wengel, J., 2008, I: Bioorganic & Medicinal Chemistry. 16, 1, s. 94-99 6 s.

Splice switching efficiency and specificity of oligonucleotides with locked nucleic acid monomers Guterstam, P., Lindgren, M., Johansson, H., Tedebark, U., Wengel, J., El-Andaloussi, S. & Langel, Ü., 2008, I: Biochemical Journal. 412, 2, s. 307-313

The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level Desnous, C., Babu, B. R., Moriou, C., Mayo, J. U. O., Favre, A., Wengel, J. & Clivio, J., 2008, I: Journal of the American Chemical Society. 130, 1, s. 30-31 2 s.

Thermodynamic, counterion and hydration effects for the incorporation of locked nucleic acid (LNA) nucleotides in duplex Kaur, H., Arora, A., Wengel, J. & Maiti, S., 2008, I: Nucleic Acids Symposium Series. 52, 1, s. 425-426

Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA Strand Wengel, J., Kaur, H. & Maiti, S., 2008, I: Biochemistry. 47, 4, s. 1218-1227

Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies Jensen, T. B., Langkjær, N. & Wengel, J., 2008, I: Nucleic Acids Symposium Series. 52, 1, s. 133-134

LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes Christiansen, J. K., Lobedanz, S., Arar, K., Wengel, J. & Vester, B., 15. sep. 2007, I: Bioorganic & Medicinal Chemistry. 15 , 18, s. 6135-6143 8 s.

Triplex-forming ability of modified oligonucleotides. Højland, T., Babu, B. R., Bryld, T. & Wengel, J., 1. jan. 2007, I: Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, s. 1411-1414 3 s.

2'-N-(Pyren-1-yl)acetyl-2'-Amino-a-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets Kumar, S. T., Wengel, J. & Hrdlicka, P. J., 2007, I: ChemBioChem. 8, 10, s. 1122-1125

Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides Prasad, A. K., Kalra, N., Yadav, Y., Kumar, R., Sharma, S. K., Patkar, S., Lange, L., Wengel, J. & Parmar, V. S., 2007, I: Chemical Communications. 2007, 25, s. 2616-2617

Direct Imaging of Hexaamine-Ruthenium(III) in Domain Boundaries in Monolayers of Single-Stranded DNA Grubb, M., Wackerbarth, H., Wengel, J. & Ulstrup, J., 2007, I: Langmuir. 23, 3, s. 1410-1413

Effective Modulation of DNA Duplex Stability by Reversible Transition Metal Complex Formation in the Minor Groove Kalek, M., Madsen, A. S. & Wengel, J., 2007, I: Journal of the American Chemical Society. 129, 30, s. 9392-9400

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites Jakobsen, M. R., Hassnoot, J., Wengel, J., Berkhout, B. & Kjems, J., 2007, I: Retrovirology. 4, 13 s., 29.

Enzymatic incorporation of LNA nucleotides into DNA strands Veedu, R. N., Vester, B. & Wengel, J., 2007, I: ChemBioChem. 8, 5, s. 490-492

Improved silencing properties using small internally segmented interfering RNAs Bramsen, J. B., Laursen, M. B., Damgaard, C. K., Lena, S. W., Babu, B. R., Wengel, J. & Kjems, J., 2007, I: Nucleic Acids Research. 35, 17, s. 5886-5897

In vitro incorporation of LNA nucleotides Veedu, R. N., Vester, B. & Wengel, J., 2007, I: Nucleosides, Nucleotides and Nucleic Acids. 26, 8-9, s. 1207-1210

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides Højland, T., Kumar, S., Babu, B. R., Umemoto, T., Albaek, N., Sharma, P. K., Nielsen, P. & Wengel, J., 2007, I: Organic & Biomolecular Chemistry. 5, 15, s. 2375-9 4 s.

LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state Kaur, H., Wengel, J. & Maiti, S., 2007, I: Biochemical and Biophysical Research Communications. 352, 1, s. 118-122

Novel applications of locked nucleic acids Veedu, R. N., Vester, B. & Wengel, J., 2007, I: Nucleic Acids Symposium Series. 51, 1, s. 29-30

Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides Prasad, A. K., Singh, S. K., Kalra, N., Singhal, N., Wengel, J. & Parmar, V. S., 2007, I: Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, s. 1517-1521

On the influence of conformational locking of sugar moieties on the absorption and circular dichroism of nucleosides from synchrotron radiation experiments Holm, A. I. S., Worm, E. S., Ckakraborty, T., Babu, B. R., Wengel, J., Vrønning Hoffmann, S. & Brøndsted Nielsen, S., 2007, I: Journal of Photochemistry and Photobiology, A: Chemistry. 187, 2-3, s. 293-298

Pyrene-Functionalized 2 ′-Amino- α -L-LNA as Potential Diagnostic Probes Kumar, S. T., Wengel, J. & Hrdlicka, P. J., 2007, I: Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, s. 1407-1409

Selective biocatalytic deacylation studies on furanose triesters: A novel and efficient approach towards bicyclonucleosides Prasad, A. K., Kalra, N., Yadav, Y., Singh, S. K., Sharma, S. K., Patkar, S., Lange, L., Olsen, C. E., Wengel, J. & Parmar, V. S., 2007, I: Organic & Biomolecular Chemistry. 5, 21, s. 3524-3530

Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned Umemoto, T., Hrdlicka, P. J., Babu, B. R. & Wengel, J., 2007, I: ChemBioChem. 8, 18, s. 2240-2248

Synthesis and biophysical studies of N2'-functionalized 2'-amino-a-L-LNA Kumar, S. T., Madsen, A. S., Wengel, J. & Hrdlicka, P. J., 2007, I: Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, s. 1403-1405

The advantages of being locked: assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes Donini, S., Clerici, M., Wengel, J., Vester, B. & Peracchi, A., 2007, I: Journal of Biological Chemistry. 282, s. 35510-35518

Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets Vester, B., Hansen, L. H., Lundberg, L. B., Babu, B. R., Sørensen, M. D., Wengel, J. & Douthwaite, S. R., 5. jun. 2006, I: BMC Molecular Biology. 7, 19, 9 s., 19.

A Conformationally Locked Aminomethyl C‐Glycoside and Studies on ItsN‐Pyren‐1‐ylcarbonyl Derivative Inserted into Oligodeoxynucleotides Verhagen, C., Bryld, T., Raunkjær, M., Vogel, S., Buchalová, K. & Wengel, J., 2006, I: European Journal of Organic Chemistry. 2006, 11, s. 2538-2548

Adsorption and surface dynamics of short DNA and LNA oligonucleotides on single-crystal Au(111) electrode surfaces Wackerbarth, H., Grubb, M., Wengel, J., Chorkendorff, I. & Ulstrup, J., 2006, I: Surface Science. 600, 10, s. 122-127

DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine Kalra, N., Parlato, C. M., Parmar, V. S. & Wengel, J., 2006, I: Bioorganic & Medicinal Chemistry Letters. 16, 12, s. 3166- 3169

Electron injection from the side of an M-DNA duplex Lindegaard, D., Wood, D. O., Wengel, J. & Lee, J. S., 2006, I: Journal of Biological Inorganic Chemistry. 11, 1, s. 82-87

Locked Nucleic Acid: High-Affinity Targeting of Complementary RNA for RNomics Kauppinen, S., Vester, B. & Wengel, J., 2006, RNA Towards Medicine. Springer, s. 405-422 (Handbook of Experimental Pharmacology, Bind 173).

Synthesis and Hybridization Studies of 2'-Amino-a-L-LNA and a Tetracyclic "Locked LNA" Kumar, S. T., Madsen, A. S., Wengel, J. & Hrdlicka, P. J., 2006, I: Journal of Organic Chemistry. 71, 11, s. 4188-4201

Synthesis and RNA-selective hybridization of alpha-L-ribo- and beta-D-lyxo-configured oligonucleotides. G., G., Babu, B. R., Vogel, S., Bryld, T., Vester, B. & Wengel, J., 2006, I: Tetrahedron. 62, 10, s. 2278-2294

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3'-O,4' -C- methylene-linked a-L-ribonucleotides Madsen, A. S., Hrdlicka, P. J., Kumar, S. T. & Wengel, J., 2006, I: Carbohydrate Research. 341, 10, s. 1398-1407

Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes Kaur, H., Arora, A., Wengel, J. & Maiti, S., 2006, I: Biochemistry. 45, 23, s. 7347-7355

Enhanced inhibition of transcription start by targeting with 2'-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids Filichev, V. V., Vester, B., Hansen, L. H., Abdel Aal, M. T., Babu, B. R., Wengel, J. & Pedersen, E. B., 1. jul. 2005, I: ChemBioChem. 6, 7, s. 1181-4 4 s.

Angstrom-scale chemical engineering: multilabeled 2'-amino-LNA probes for nucleic acid detection in homogenous fluorescence assays Hrdlicka, P. J., Babu, B. R., Sørensen, M. D., Harrit, N. & Wengel, J., 2005, Chemistry of Nucleic Acid Components. Bind 7. s. 27-28 (Collection Symposium Series).

DNA self-assembling systems: Branched oligonucleotides as building blocks and monitoring by pyrene excimer band formation Lindegaard, D., Babu, B. R. & Wengel, J., 2005, I: Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, s. 679-681

Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis Brunet, E., Alberti, P., Perrouault, L., Babu, B. R., Wengel, J. & Giovannangeli, C., 2005, I: Journal of Biological Chemistry. 280, 20, s. 20076-20085

Inhibition of HIV-1 TAT-dependent trans-activation by steric block oligonucleotide analogues containing amino modifications Ivanova, G. D., Arzumanov, A. A., Babu, B. R., Karla, N., Sweedler, D., Beigelman, L., Wengel, J. & Gait, M. J., 2005, XIIIth Symposium on Chemistry of Nucleic Acid Components. s. 367-371 (Collection Symposium Series; Nr. 7).

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplexforming oligonucleotides: Improving DNA binding properties and reaching cellular activities Brunet, E., Corgnali, M., Perrouault, L., Roig, V., Asseline, U., Sørensen, M. D., Babu, B. R., Wengel, J. & Giovannangeli, C., 2005, I: Nucleic Acids Research. 33, 13, s. 4223-4234

Investigations toward new lead compounds from medicinally important plants Prasad, A. K., Kumar, V., Arya, P., Kumar, S., Dabur, R., Singh, N., Chhillar, A. K., Sharma, G. L., Ghosh, B., Wengel, J., Olsen, C. E. & Parmar, V. S., 2005, I: Pure and Applied Chemistry. 77, 1, s. 25-40

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics Kauppinen, S., Vester, B. & Wengel, J., 2005, I: Drug Discovery Today. 2, 3, s. 287-290 4 s.

Locked nucleic acid synthesis Pfundheller, H. M., Sørensen, A. M., Lomholt, C., Johansen, A. M., Koch, T. & Wengel, J., 2005, Oligonucleotide Synthesis. Herdewijn, P. (red.). Springer, s. 127-145 (Methods in Molecular Biology, Bind 288).

Multilabeled Pyrene-Functionalized 2'-Amino-LNA Probes for Nucleic Acid Detection in Homogeneous Fluorescence Assays Hrdlicka, P. J., Babu, B. R., Sørensen, M. D., Harrit, N. & Wengel, J., 2005, I: Journal of the American Chemical Society. 127, 38, s. 13293-13299

Novel Nucleic Acid Architectures Involving LNA (Locked Nucleic Acid) and Pyrene Residues: Results from an Indo-Danish Collaboration Babu, B. R., Raunak, Sørensen, M. D., Hrdlicka, P. J., Trikha, S., Prasad, S. K., Parmar, V. S. & Wengel, J., 2005, I: Pure and Applied Chemistry. 77, 1, s. 319-326

Oligodeoxynucleotides containing diastereomeric O2',C3'-linked bicyclic nucleotide units for functionalization of the major groove of nucleic acid duplexes: A summery and novel derivatives Raunkjær, M., Haselmann, K. & Wengel, J., 2005, I: Journal of Carbohydrate Chemistry. 24, 4-6, s. 475-502

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-ß-alanyl 2'-amino-LNA Babu, B. R., Hrdlicka, P. J., McKenzie, C. & Wengel, J., 2005, I: Chemical Communications. 41, 13, s. 1705-1707

Selective transacylation reactions on 4-aryl-3, 4-dihydropyrimidin-2-ones and nucleosides mediated by novel lipases Poonam, Prasad, A. K., Mukherjee, C., Shakya, G., Maghwanshi, G. K., Wengel, J., Saxena, R. K. & Parmar, V. S., 2005, I: Pure and Applied Chemistry. 77, 1, s. 237-243

Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'- C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd) Hrdlicka, P. J., Andersen, N. K., Jepsen, J. S., Hansen, F. G., Haselmann, K., Nielsen, C. & Wengel, J., 2005, I: Bioorganic & Medicinal Chemistry. 13, 7, s. 2597-2621

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECYD) Hrdlicka, P. J., Jepsen, J. S. & Wengel, J., 2005, I: Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, s. 397-400

Synthesis and Biological Evaluation of Nucleobase-modified Analogs of the Anticancer Compounds 3'-C-Ethynyluridine (EUrd) and 3'-Cethynylcytidine (ECyd) Hrdlicka, P. J., Jepsen, J. S., Nielsen, C. & Wengel, J., 2005, I: Bioorganic & Medicinal Chemistry. 13, 4, s. 1249-1260

Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C- Methyleneribonucleotides Hrdlicka, P. J., Kumar, T. S. & Wengel, J., 2005, I: European Journal of Organic Chemistry. 2005, 24, s. 5184-5188

Synthesis and thermal denaturation studies of novel 2'-O,3'-C-linked bicyclic oligonucleotides with a methoxy or a piperazino group facing the major groove of nucleic acid duplexes Raunkjær, M., Sørensen, M. D. & Wengel, J., 2005, I: Organic & Biomolecular Chemistry. 2005, 1, s. 130-135

Synthesis of a 2'-Amino-a-L-LNA-T Phosphoramidite Hrdlicka, P. J., Kumar, T. S. & Wengel, J., 2005, I: Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, s. 1101-1104

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-L-LNA Hrdlicka, P. J., Kumar, T. S. & Wengel, J., 2005, I: Chemical Communications. 2005, 34, s. 4279-4281

XNA (xylo nucleic acid): A summary and new derivatives Babu, B. R., Raunak, Poopeiko, N. E., Juhl, M., Bond, A., Parmar, V. S. & Wengel, J., 2005, I: European Journal of Organic Chemistry. 2005, 11, s. 2297-2321

3'-C-Branched LNA-type nucleosides locked in an N-type furanose ring conformation: Synthesis, incorporation into oligodeoxynucleotides and hybridization studies Meldgaard, M., Hansen, F. C. & Wengel, J., 2004, I: Journal of Organic Chemistry. 69, 19, s. 6310-6322

Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl- functionalized 2'-amino-DNA Kalra, N., Babu, B. R., Parmar, V. S. & Wengel, J., 2004, I: Organic & Biomolecular Chemistry. 2004, 20, s. 2885-2887

DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl- functionalized 4'-C-piperazinomethyl-DNA. Bryld, T., Højland, T. & Wengel, J., 2004, I: Chemical Communications. 2004, 9, s. 1064-1065

Improved RNA cleavage by LNAzyme derivatives of DNAzymes. Vester, B., Lundberg, L. B., Sørensen, M. D., Babu, B. R., Douthwaite, S. R. & Wengel, J., 2004, I: Biochemical Society Transactions. 32, 1, s. 37-40

Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity. Hrdlicka, P. J., Sørensen, A. B. & Wengel, J., 2004, I: Chemical Communications. 2004, 13, s. 1478-1479

LNA (Locked Nucleic Acid): High Affinity Targeting of Complementary RNA and DNA Vester, B. & Wengel, J., 2004, I: Biochemistry. 43, 42, s. 13233-13241

LNA-Antisense rivals siRNA for gene silencing Jepsen, J. S. & Wengel, J., 2004, I: Current Opinion in Drug Discovery & Development. 7, 2, s. 188-194

Locked Nucleic Acid: a potent nucleic acid analogue in therapeutics and biotechnology Jepsen, J. S., Sørensen, M. D. & Wengel, J., 2004, I: Oligonucleotides. 14, 2, s. 130-146

Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: Thermal stability studies. Filichev, V. V., Hilmy, K. M. H., Christensen, U. B., Pedersen, E. B., Babu, B. R. & Wengel, J., 2004, I: ChemBioChem. 5, 12, s. 1673-1679

NMR studies of fully modified locked nucleic acid (LNA) hybrids: Solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid Nielsen, K. E., Rasmussen, J., Kumar, R., Wengel, J., Jacobsen, J. P. & Petersen, M., 2004, I: Bioconjugate Chemistry. 15, 3, s. 449-457

Nucleic acid nanotechnology - towards Ångström-scale engineering. Wengel, J., 2004, I: Organic & Biomolecular Chemistry. 2004, 3, s. 277-280

Oligodeoxynucleotides containing a-L-ribo configured LNA-type C-aryl nucleotides Raunak, Babu, B. R., Sørensen, M. D., Parmar, V. S., Harrit, N. H. & Wengel, J., 2004, I: Organic & Biomolecular Chemistry. 2004, 1, s. 80-89

Parallel nucleic acid recognition by the LNA (Locked Nucleic Acid) stereoisomers ß-L-LNA and a-D-LNA; studies in the mirror image world. Christensen, N. K., Bryld, T., Sørensen, M. D., Arar, K., Wengel, J. & Nielsen, P., 2004, I: Chemical Communications. s. 282-283

Synthesis of 1-(2'-O-methyl-ß-D-ribofuranosyl)-5-nitroindole and its phosphoramidite derivative. Gaubert, G. & Wengel, J., 2004, I: Tetrahedron Letters. 45, 29, s. 5629-5632

A substituted triaza crown ether as a binding site in DNA conjugates Vogel, S., Rohr, K., Otto, D. & Wengel, J., 1. jan. 2003, I: Chemical Communications. 2003, 8, s. 1006-1007

2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides Babu, B. R., Keinicke, L., Petersen, M., Nielsen, C. & Wengel, J., 2003, I: Organic & Biomolecular Chemistry. 2003, 1, s. 3514-3526

Aryl-β-C-LNA Monomers as Universal Hybridization Probes Babu, B. R. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1317-1319

Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N- alkylated 2'-amino-LNA monomers Sørensen, M. D., Petersen, M. & Wengel, J., 2003, I: Chemical Communications. s. 2130-2131

Highly efficient diastereoselective biocatalytic acylation of a diastereotopic furanose diol and synthesis of key intermediates for amino derivatized bicyclonucleosides Prasad, A. K., Roy, S., Kumar, R., Kalra, N., Wengel, J., Olsen, C. E., Cholli, A. L., Samuelson, L. A., Kumar, J., Watterson, A. C., Gross, R. A. & Parmar, V. S., 2003, I: Tetrahedron. 59, 8, s. 1333-1338

Improved Synthesis of 2'-Amino-LNA Christensen, S. M., Rosenbohm, C., Sørensen, M., Larsen, L-E., Wengel, J. & Koch, T., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1131-1133

LNA and α-L-LNA: Towards Therapeutic Applications Wengel, J., Vester, B., Lundberg, L. B., Douthwaite, S., Sørensen, M. D., Babu, B. R., Gait, M. J., Arzumanov, A., Petersen, M. & Nielsen, J. T., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 601-604

LNA: a versatile tool for the therapeutics and genomics Petersen, M. & Wengel, J., 2003, I: Trends in Biotechnology. 21, 2, s. 74-81

Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage Lauritsen, A., Dahl, B. M., Dahl, O., Vester, B. & Wengel, J., 2003, I: Bioorganic & Medicinal Chemistry Letters. 13, 2, s. 253-256

N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex Raunkjær, M., Bryld, T. & Wengel, J., 2003, I: Chemical Communications. 2003, 13, s. 1604-1605

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation Tømmerholt, H. V., Christensen, N. K., Nielsen, P., Wengel, J., Stein, P. C., Jacobsen, J. P. & Petersen, M., 2003, I: Organic & Biomolecular Chemistry. 2003, 10, s. 1790-1797

Structural Characterization of LNA and α-L-LNA Hybridized to RNA Petersen, M., Nielsen, J. T., Bondensgaard, K., Wengel, J. & Jacobsen, J. P., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1691-1693

Synthesis and Hybridization Properties of Oligodeoxynucleotides Containing 3′-Deoxy-3′-C-methyleneuridine Lindegaard, D. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1159-1161

Synthesis of 2'-amino-LNA: A new strategy Rosenbohm, C., Christensen, S. M., Sørensen, M. D., Pedersen, D. S., Larsen, L-E., Wengel, J. & Koch, T., 2003, I: Organic & Biomolecular Chemistry. 2003, 4, s. 655-663

Synthesis of 2'-Spiro Ribo- and Arabinonucleosides Babu, R. B., Keinicke, L. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1313-1315

Synthesis of a Base-Protected xylo-LNA Adenine Nucleoside Bryld, T. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1163-1165

Synthesis of a Base-Protected α-L-LNA Guanine Nucleoside Gaubert, G. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1155-1157

Synthesis of an Asymmetrically Substituted AZA Crown Ether as Metal and Amino Acid Binding Site in DNA Conjugates Vogel, S., Rohr, K., Otta, D. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1039-1040

Xylo-configured oligonucleotides (XNA, Xylo Nucleic Acid): Synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements Poopeiko, N. E., Juhl, M., Vester, B., Sørensen, M. D. & Wengel, J., 2003, I: Bioorganic & Medicinal Chemistry Letters. 13 , 14, s. 2285-2290

Xylo-Configured Oligonucleotides (XNA, Xylo Nucleic Acids): Synthesis and Hybridization Studies Poopeiko, N. E., Dahl, B. M. & Wengel, J., 2003, I: Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, s. 1147-1149

3',4'-trans-Linked bicyclic nucleosides locked in S-type conformations Thomasen, H., Meldgaard, M., Freitag, M., Petersen, M., Wengel, J. & Nielsen, P., 2002, I: Chemical Communications. 2002, 17, s. 1888-1889

Conformationally locked aryl C-nucleosides: synthesis of phosphoramidite monomers and incorporation into single- stranded DNA and LNA (locked nucleic acid) Babu, B. R., Prasad, A. K., Trikhaab, S., Thorup, N., Parmar, V. S. & Wengel, J., 2002, I: Royal Chemical Society. Journal. Perkin Transactions 1. 2002, 22, s. 2509-2519

Convenient synthesis of 1-(1,3-dihydroxy-2-propyl)-4-nitroimidazoles Wengel, J. & Walczak, K., 2002, I: Polish Journal of Chemistry. 76, 1, s. 67-71

LNAzymes: Incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage Vester, B., Lundberg, L. B., Sørensen, M. D., Babu, B. R., Douthwaite, S. & Wengel, J., 2002, I: Journal of the American Chemical Society. 124, 46, s. 13682-13683

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids Petersen, M., Bondensgaard, K., Wengel, J. & Petersen, J. P., 2002, I: Journal of the American Chemical Society. 124, 21 , s. 5974–5982

Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: Synthesis and high-affinity nucleic acid hybridization Lauritsen, A. & Wengel, J., 2002, I: Chemical Communications. 2002, 5, s. 530-531

Synthesis and antiviral evaluation of novel conformationally locked nucleosides and masked 5'-phosphate derivatives thereof Bryld, T., Sørensen, M. H., Nielsen, P., Koch, T., Nielsen, C. & Wengel, J., 2002, I: Royal Chemical Society. Journal. Perkin Transactions 1. 2002, 14, s. 1655-1662

α‐L‐LNA (α‐L‐ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study: An NMR spectroscopic study Nielsen, K. M. E., Petersen, M., Håkansson, A. E., Wengel, J. & Jacobsen, J. P., 2002, I: Chemistry: A European Journal. 8, 13, s. 3001-3009

α-l-ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties Sørensen, M. D., Kværnø, L., Bryld, T., Håkansson, A. E., Verbeure, B., Gaubert, G., Herdewijn, P. & Wengel, J., 2002, I: Journal of the American Chemical Society. 124, 10, s. 2164-2176

α-l-RNA (α-l-ribo Configured RNA): Synthesis and RNA-Selective Hybridization of α-l-RNA/α-l-LNA Chimera Keinicke, L., Sørensen, M. D. & Wengel, J., 2002, I: Bioorganic & Medicinal Chemistry Letters. 12, 4, s. 593-596

A comparison of the solution structures of an LNA-DNA duplex and the unmodified DNA:DNA duplex Jensen, G. A., Singh, S. K., Kumar, R., Wengel, J. & Jacobsen, J. P., 2001, I: Royal Chemical Society. Journal. Perkin Transactions 2. 2001, 7, s. 1224-1232

Antisense molecules and furanose conformations - is it really that simple? Kværnø, L. & Wengel, J., 2001, I: Chemical Communications. 2001, 16, s. 1419-1424

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides Arzumanov, A., Walsh, A. P., Rajwanshi, V. K., Kumar, R., Wengel, J. & Grant, M. J., 2001, I: Biochemistry. 40, 48, s. 14645-14654

LNA (Locked Nucleic Acid) Wengel, J., 2001, Antisense Drug Technology. Crooke, S. T. (red.). New York: Marcel Dekker, s. 339-57

LNA (locked nucleic acid) and the diastereoisomeric (alfa)-L-LNA: Conformational tuning and high-affinity recognition of DNA/RNA targets Wengel, J., Petersen, M., Nielsen, K. E., Jensen, G. A., Håkansson, A. E., Kumar, R., Sørensen, M. D., Rajwanshi, V. K., Bryld, T. & Jacobsen, J. P., 2001, I: Nucleosides, Nucleotides and Nucleic Acids. 20, 4-7, s. 389-396

Locked nucleic acids (LNA): A promising molecular family for gene-function analysis and antisense drug development Ørum, H. & Wengel, J., 2001, I: Current Opinion in Molecular Therapeutics. 3, 3, s. 239-243

Mechanism of biochemical action of substituted benzopyran-2-ones: Part 8: Acetoxycoumarin: Protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom Raj, H. G., Kohli, E., Goswami, R., Goel, S., Rastogi, R. C., Jain, S. C., Wengel, J., Olsen, C. E. & Parmar, V. S., 2001, I: Bioorganic & Medicinal Chemistry. 9, 5, s. 1085-1089

Novel bicyclic nucleoside analogue (1S,5S,6S)-6-hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: Synthesis and incorporation into oligodeoxynucleotides Kværnø, L. & Wengel, J., 2001, I: Journal of Organic Chemistry. 66, 16, s. 5498–5503

Oligonucleotide analogue inteference with the HIV-1 TAT protein-tar RNA interaction Arzumanov, A., Walsh, A. P., Liu, X., Rajwanshi, V. K., Wengel, J. & Gait, M. J., 2001, I: Nucleosides, Nucleotides and Nucleic Acids. 20, 4-7, s. 471-480

Parallel synthesis of a small library of novel aminoglycoside analogs based on 2-amino-2-deoxy-D-glucose and D-ribose scaffolds Rosenbohm, C., Vanden Berghe, D., Vlietinck, A. & Wengel, J., 2001, I: Tetrahedron. 57, 29, s. 6277-6287

Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach Karwowski, B., Okruszek, A., Wengel, J. & Stec, W. J., 2001, I: Bioorganic & Medicinal Chemistry Letters. 11, s. 1001- 1003

Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions Christensen, U., Jacobsen, N., Rajwanshi, V. K., Wengel, J. & Koch, T., 2001, I: Biochemical Journal. 354, 3, s. 481-484

Synthesis and evaluation of anti-HIV activity of 3-azido-4-hydroxymethyl)tetrahydrofuran derivatives containing 2-(thymin- 1-yl)methyl, 2-(cytosin-1-yl)methyl or 2-(adenin-9-yl)methyl substituents - a new series of AZT analogues Olsen, A. G., Nielsen, C. & Wengel, J., 2001, I: Royal Chemical Society. Journal. Perkin Transactions 1. 2001, 8, s. 900- 904

Synthesis of a novel bicyclic nucleoside restricted to an S-type conformation and initial evaluation of its hybridization properties when incorporated into oligodeoxynucleotides Kværnø, L., Wightman, R. H. & Wengel, J., 2001, I: Journal of Organic Chemistry. 66, 15, s. 5106–5112

The (alfa)-L-ribo-isomers of RNA and LNA (locked nucleic acid) Sørensen, M. D., Kværnø, L., Bryld, T., H?kansson, A. E., Keinicke, L., Verbeure, B., Herdewijn, P. & Wengel, J., 2001, I: Nucleic Acids Research. Suppl. 1, s. 25-26

The adenine derivative of (alfa)-L-LNA ((alfa)-L-ribo configured locked nucleic acid): Synthesis and high-affinity hybridization towards DNA, RNA, LNA and (alfa)-L-LNA complementary sequences Håkansson, A. E. & Wengel, J., 2001, I: Bioorganic & Medicinal Chemistry Letters. 11, 7, s. 935-938

Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer Babu, B. R. & Wengel, J., 2001, I: Chemical Communications. 2001, 20, s. 2114-2115

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer. Egli, M., Minasov, G., Teplova, M., Kumar, R. & Wengel, J., 2001, I: Chemical Communications. 2001, 7, s. 651-652

α-l-LNA (α-i-ribo Configured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations: A study by NMR spectroscopy and molecular dynamics simulations Petersen, M., Håkansson, A. E., Wengel, J. & Jacobsen, J. P., 2001, I: Journal of the American Chemical Society. 123, 30 , s. 7431–7432

Bicyclic nucleosides and conformational restriction of oligonucleotides Meldgaard, M. & Wengel, J., 2000, I: Royal Chemical Society. Journal. Perkin Transactions 1. 2000, 21, s. 3539-3554

Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch Sørensen, M. D., Meldgaard, M., Rajwanshi, V. K. & Wengel, J., 2000, I: Bioorganic & Medicinal Chemistry Letters. 10, 16 , s. 1853-1856

Convenient syntheses of 7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: ?-L-ribo- and ?-L- xylo-configured LNA nucleosides Håkansson, A. E., Koshkin, A. A., Sørensen, M. D. & Wengel, J., 2000, I: Journal of Organic Chemistry. 65, 17, s. 5161- 5166

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones: Part 6: Hydrolysis of 7,8-diacetoxy-4- methylcoumarin by a novel deacetylase in rat liver microsomes - a simple method for assay and characterization Raj, H. G., Parmar, V. S., Jain, S. C., Goel, S., Tyagi, Y. K., Sharma, S. K., Olsen, C. E. & Wengel, J., 2000, I: Bioorganic & Medicinal Chemistry. 8, 1, s. 233-237

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones: Part 7: Assay and characterization of 7,8- diacetoxy-4-methylcoumarin: Protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathione S-transferase Raj, H. G., Parmar, V. S., Jain, S. C., Kohli, E., Ahmad, N., Goel, S., Tyagi, Y. K., Sharma, S. K., Wengel, J. & Olsen, C. E., 2000, I: Bioorganic & Medicinal Chemistry. 8, 7, s. 1707-1712

NMR structure of a DNA duplex containing the modified nucleotide 3'-C-(hydroxymethyl)thymidine Godtfredsen, C. H., Viswanadham, G., Jørgensen, P. N., Wengel, J. & Jacobsen, J. P., 2000, I: Asian Chemistry Letters. 4 , s. 171-84

Oligonucleotides containing novel 4'-C- or 3'-C-aminoalkyl branched thymidines Pfundheller, H. M., Bryld, T., Olsen, C. E. & Wengel, J., 2000, I: Helvetica Chimica Acta. 83, 1, s. 128-151

Potent and Nontoxic Antisense Oligonucleotides Containing Locked Nucleic Acids Wahlestedt, C., Salmi, P., Good, L., Kela, J., Johnsson, T., Hökflet, T., Broberger, C., Porreca, F., Lai, J., Ren, K., Ossipov, M., Koshkin, A., Oerum, H., Jacobsen, M. H. & Wengel, J., 2000, I: Proceedings of the National Academy of Science of the United States of America. 97, 10, s. 5633-5638

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA Minasov, G., Teplova, M., Nielsen, P., Wengel, J. & Egli, M., 2000, I: Biochemistry. 39, 13, s. 3525–3532

Structural studies of LNA:RNA duplexes by NMR: Conformations and implications for RNase H activity Bondensgaard, K., Petersen, M., Singh, S. K., Rajwanshi, V. K., Kumar, R., Wengel, J. & Jacobsen, J. P., 2000, I: Chemistry: A European Journal. 6, 15, s. 2687-2695

Synthesis and evaluation of anti-HIV-1 activity of 3'-azido-3'-deoxy 2'-O,4'-C-methylene-linked bicyclic thymine nucleosides Olsen, A. G., Rajwanshi, V. K., Nielsen, C. & Wengel, J., 2000, I: Royal Chemical Society. Journal. Perkin Transactions 1. 2000, 21, s. 3610-3614

Synthesis of abasic LNA (Locked Nucleic Acid) and two seco-LNA derivatives and evaluation of their hybridization properties compared with their more flexible DNA counterparts Kværnø, L., Kumar, R., Dahl, B. M., Olsen, C. E. & Wengel, J., 2000, I: Journal of Organic Chemistry. 65, 17, s. 5167- 5176

The conformations of locked nucleic acids (LNA) Petersen, M., Nielsen, C. B., Nielsen, K. E., Jensen, G. A., Bondensgaard, K., Singh, S. K., Rajwanshi, V. K., Koshkin, A. A., Dahl, B. M. & Wengel, J., 2000, I: Journal of Molecular Recognition. 13, 1, s. 44-53

The eight stereoisomers of LNA (Locked Nucleic Acid): A remarkable family of strong RNA binding molecules Rajwanshi, V. K., Håkansson, A. E., Sørensen, M. D., Pitsch, S., Singh, S. K., Kumar, R., Nielsen, P. & Wengel, J., 2000, I: Angewandte Chemie - International Edition. 39, 9, s. 1656-1659

The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-?-D-arabinofuranosyl)thymidine nucleoside Jørgensen, L. B., Nielsen, P., Wengel, J. & Jacobsen, J. P., 2000, I: Journal of Biomolecular Structure & Dynamics. 18, 1, s. 45-57

The solution structure of a Locked Nucleic Acid (LNA) hybridized to DNA: NMR study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) duplex containig four locked nucleotides Nielsen, K. E., Singh, S. K., Wengel, J. & Jacobsen, J. P., 2000, I: Bioconjugate Chemistry. 11, 2, s. 228–238

A new synthetic approach towards ?- and ?-LNA (locked nucleic acids) Nielsen, P. & Wengel, J., 1999, I: Nucleosides, Nucleotides and Nucleic Acids. 18, 5-5, s. 701-702

Evaluation of oligonucleotides containing two novel 2'-Omethyl modified nucleotide monomers: A 3'-C-allyl and a 2'-O,3'- C-linked bicyclic derivative Pfundheller, H. M., Koshkin, AA., Olsen, C. E. & Wengel, J., 1999, I: Nucleosides, Nucleotides and Nucleic Acids. 18, 9, s. 2017-2030

LNA (locked nucleic acids) Wengel, J., Koshkin, A., Singh, S. K., Nielsen, P., Meldgaard, M., Rajwanshi, V. K., Kumar, R., Skouv, J., Nielsen, C. B. & Jacobsen, J. P., 1999, I: Nucleosides, Nucleotides and Nucleic Acids. 18, 6-7, s. 1365-1370

Oligonucleotides containing 4'-C-aminomethyl-2'-modified thymidines show increased binding affinity towards DNA and RNA Pfundheller, H. M. & Wengel, J., 1999, I: Bioorganic & Medicinal Chemistry Letters. 9, 18, s. 2667-2672

The solution structure of a locked nucleic acid (LNA) hybridized to DNA Nielsen, C. B., Singh, S. K., Wengel, J. & Jacobsen, J. P., 1999, I: Journal of Biomolecular Structure & Dynamics. 17, 2, s. 175-191

A Novel Class of Oligonucleotide Analogues Containing 2'-O,3'-C-Linked [3.2.0]Bicyclo-arabinonucleoside Monomers: Synthesis, Thermal Affinity Studies and Molecular Modelling Christensen, N. K., Petersen, M., Nielsen, P., Jacobsen, J. P., Olsen, C. E. & Wengel, J., 1998, I: Journal of the American Chemical Society. 120, 22, s. 5458-5463

LNA (Locked Nucleic Acids): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes Koshkin, A. A., Nielsen, P., Meldgaard, M., Rajwanshi, V. K., Singh, S. K. & Wengel, J., 1998, I: Journal of the American Chemical Society. 120, 50, s. 13252-13253

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition Singh, S. K., Nielsen, P., Koshkin, A. A. & Wengel, J., 1998, I: Chemical Communications. 1998, 4, s. 455-456

LNA (Locked Nucleic Acids): Synthesis of Adenin, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and Unprecedented Nucleic Acid Recognition Koshkin, A. A., Singh, S. K., Nielsen, P., Rajwanshi, V. K., Kumar, R., Meldgaard, M., Olsen, C. E. & Wengel, J., 1998, I: Tetrahedron. 54, 14, s. 3607-3630

Synthesis and chemoselective activation of phenyl 3,5-di-O-benzyl-2-O,4-C-methylene-1-thio-b-D-ribofuranoside: a key synthon towards a-LNA Nielsen, P. & Wengel, J., 1998, I: Chemical Communications. 1998, 23, s. 2645-2646

Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides Pfundheller, H. M., Jørgensen, P. N., Sørensen, U. S., Sharma, S. K., Grimstrup, M., Ströch, C., Nielsen, P., Viswanadham, G., Olsen, C. E. & Wengel, J., 1998, I: Royal Chemical Society. Journal. Perkin Transactions 1. 1998, 8, s. 1409-1422

A novel class of conformationally restricted oligonucleotide analogues: synthesis of 2',3'-bridged monomers and RNA- selective hybridisation Nielsen, P., Pfundheller, H. M. & Wengel, J., 1997, I: Chemical Communications. 1997, 9, s. 825-826

Introduction of a universal solid support for oligonucleotide synthesis Scheuer-Larsen, C., Rosenbohm, C., Jørgensen, T. J. D. & Wengel, J., 1997, I: Nucleosides, Nucleotides and Nucleic Acids. 16, 1-2, s. 67-80

Synthesis and Evaluation of Novel Oligodeoxynucleotides Containing 3′-C-(3-Benzoyloxypropyl)thymidine and Bicyclo Nucleoside Derivatives Pfundheller, H. M., Nielsen, P. & Wengel, J., 1997, I: Nucleosides, Nucleotides and Nucleic Acids. 16, 7-9, s. 1439-1442

Synthesis of 2'-O,3'-C-linked bicyclic nucleosides and bicyclic oligonucleotides Nielsen, P., Pfundheller, H. M., Olsen, C. E. & Wengel, J., 1997, I: Royal Chemical Society. Journal. Perkin Transactions 1. 1997, 22, s. 3423-3434

Stereoselective Preparation of 3'-C-Allyluridines and 3'-Spiro-gamma-Lactone Uridine Analogues Nielsen, P., Larsen, K. & Wengel, J., 1996, I: Acta Chemica Scandinavica. 50, 11, s. 1030-1035

Oligonucleotide analogues containing 4'-C-(hydroxymethyl)uridine: synthesis, evaluation and mass spectrometric analysis Nielsen, K. D., Kirpekar, F., Roepstorff, P. & Wengel, J., nov. 1995, I: Bioorganic & Medicinal Chemistry. 3, 11, s. 1493- 502 10 s.

Evaluation of Oligonucleotides with Novel Modifications Larsen, E., Danel, K., Abdel-Aleem, A-A. H., Nielsen, P., Wengel, J. & Pedersen, E. B., 1995, I: Nucleosides, Nucleotides and Nucleic Acids. 14, 3-5, s. 1097-1100

Synthesis and Evaluation of Oligodeoxynucleotides Containing Acyclic Nucleosides: Introduction of Three Novel Analogues and a Summary Nielsen, P., Dreiøe, L. H. & Wengel, J., 1995, I: Bioorganic & Medicinal Chemistry. 3, 1, s. 19-28

Synthesis of 3ʹ-C-(Hydroxymethyl)thymidine: Introduction of a Novel Class of Deoxynucleosides and Oligodeoxynucleotides Jorgensen, P. N., Stein, P. C. & Wengel, J., 1. sep. 1994, I: Journal of the American Chemical Society. 116, 5, s. 2231- 2232

Incorporation of (R)- and (S)-3´,4´-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability Nielsen, P., Kirpekar, F. & Wengel, J., 1994, I: Nucleic Acids Research. 22, 5, s. 703-710