Jesper Wengel Professor, Ph.D. Nukleinsyrecentret (NAC) Personal Data: Born 1963; Married; Five children University Address Nucleic Acid Center Department of Physics and Chemistry University of Southern Denmark, Odense Campusvej 55 DK-5230 Odense M, Denmark Tel. +45 6550 2510 Fax. +45 6615 8780 E-mail: [email protected] University Education Dec.1988 Cand. scient.: Odense University (Chemistry/Biology) Jan.1992 Ph.D.: Odense University: "Synthesis of 2',3'-Dideoxynucleoside Analogues with Potential Activity against HIV" Academic Employment Oct. 1990 - Jun. Research Fellow: Department of Chemistry and Biochemistry, University of Colorado, USA 1991 Sep. 1991 - Mar. Assistant Professor: In organic chemistry at Department of Chemistry, Odense University 1994 Apr. 1994 - Sep. Associate Professor: In organic chemistry at Department of Chemistry, Odense University 1996 Oct. 1996 - Jul. Professor: In bioorganic chemistry at Department of Chemistry, University of Copenhagen 2000 Aug. 2000 - Professor: In organic chemistry at Department of Chemistry, University of Southern Denmark, Odense Present Research Bioorganic chemistry; Medicinal chemistry; Nucleic acid biotechnology; Nanobioscience Publications Author or co-author of >400 research papers in peer-reviewed scientific journals. H-Index = 57; Citations > 15.200 (SCI: Wengel J*; first publication in 1989) IPR and Innovation Inventor or co-inventor on more than ten patents and patent applications. Co-inventor of the LNA (Locked Nucleic Acid) technology that forms the basis of the business activities of the companies Exiqon A/S (~60 employees) and Santaris Pharma A/S (~70 employees). Co-founder (2006) of RiboTask ApS. Administration and Leadership experience 1991-1992 and Member of the board, Department of Chemistry, Odense University 1996 1997-2000 Member of the board, The Danish Chemical Society: Organic Chemistry Section 1999-2000 Chairman of the board, The Danish Chemical Society: Organic Chemistry Section 1998-2000 Head and Chairman of the board, Chemical Laboratory II, Department of Chemistry, University of Copenhagen 2001-2011 Director of the Nucleic Acid Center funded by the Danish National Research Foundation 2004-2013 Member of the Steering Group for Biotechnological Research Collaboration between India and Denmark, Ministry of Science, Innovation and Higher Education 2005- Member of "Praksisudvalget", University of Southern Denmark 2006- Chairman of the board, RiboTask ApS 2006-2012 Member of the Leadership Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark 2011-2012 Chairman of the Research Strategy Board. Faculty of Science, University of Southern Denmark 2012- Director of the Biomolecular Nanoscale Engineering Center – A VKR Center of Excellence funded by the Villum Foundation 2013- Chairman, Academic Council, Faculty of Science, University of Southern Denmark 2015- Chairman, University Council, University of Southern Denmark 2016- Member of the board, Independent Research Fund Denmark Memberships of diverse boards and committees, e.g. patent committee KU; Ph.D study boards SDU, ATV boards, Carlsberg chemistry prize committee, academic and industrial advisory boards, and evaluation and employment committees Knighted 2012 Ridder af Dannebrogsordenen (Knight of Dannebrog) Research and Innovation Awards 1997 Bjerrum-Brøndsted-Lang Lecturer 2000 Parker-Davis Lecturer, Ohio State University 2001 The Bjerrum Chemistry Award 2002 The Lundbeck Foundation's Research Prize for Young Researchers 2002 The Danish Academy of Natural Sciences Industry Award 2004 The UCB Award for Excellence in Medicinal Chemistry 2005 Villum Kann Rasmussen Grant for Technical Research 2006 OBC Lecture Award Winner 2007 The Danish Association of Masters and PhD Research 2008 The Ib Henriksen Foundation Research Award Elected Academy Memberships 2003- The Royal Danish Academy of Sciences and Letters 2000- The Danish Academy of Natural Sciences 2005- The Danish Academy of Technical Sciences Teaching Awards 1995 Natural Science Teaching Award, Odense University 2000 Biochemistry Teaching Award, University of Copenhagen Major Research Funding since 2000 ERC Advanced Grant EVOLNA – Evolution of LNA-based Aptamers (2011-2016; 2.5 mio. €) International Funds – Partner in EU projects, local PI Pharmaco-Gene (LSHB-CT-2007-037283) - Design of Targeted Gene Pharmaceutics Using Self-assembling Functional Entities (2007-2010; 0.43 mio. € share of funding) RIGHT (LSHB-CT-2004-005276) - RNA Interference Technology as Human Therapeutic Tool (2005-2008; 0.74 mio. € share of funding) NAC-DRUG (MEST-CT-2004-504018) - Nucleic Acid Based Drug Design Training Center (2004-2008; 1.65 mio. €) Public Danish Funds – Center Director and PI The Nucleic Acid Center (2001-2011; 66 mio. DKK) - A center of excellence funded by The Danish National Research Foundation Studies on naturally occurring compounds of potential use in health and agriculture (1995-1998; 4.0 mio. DKK) - A capacity-building research program between Odense University, KVL and Delhi University funded by DANIDA Novel medicines for treatment of cancer and neurological disorders (2008-2012; 5.0 mio. DKK share of funding) - A HTF platform funded by The Danish Advanced Technology Foundation Private Danish Funds – Center Director and PI The Biomolecular Nanoscale Engineering Center (2012-2022; 60 mio. DKK) – A VKR Center of Excellence funded by the Villum Foundation Publications Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria? Pereira, S., Yao, R., Gomes, M., Jørgensen, P. T., Wengel, J., Azevedo, N. F. & Santos, R. S., apr. 2021, I: Antibiotics. 10 , 4, 12 s., 379. Polyamine-Functionalized 2′-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA Danielsen, M. B., Christensen, N. J., Jørgensen, P. T., Jensen, K. J., Wengel, J. & Lou, C., 18. jan. 2021, I: Chemistry - A European Journal. 27, 4, s. 1416-1422 Cationic oligonucleotide derivatives and conjugates: A favorable approach for enhanced DNA and RNA targeting oligonucleotides Danielsen, M. B. & Wengel, J., 2021, I: Beilstein Journal of Organic Chemistry. 17, s. 1828-1848 Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J., 4. dec. 2020, I: Molecular Therapy - Nucleic Acids. 22, s. 994-1003 NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation Carreras-Badosa, G., Maslovskaja, J., Periyasamy, K., Urgard, E., Padari, K., Vaher, H., Tserel, L., Gestin, M., Kisand, K. , Arukuusk, P., Lou, C., Langel, Ü., Wengel, J., Pooga, M. & Rebane, A., dec. 2020, I: Biomaterials. 262, 120316. Reprint of “Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)- electrode surfaces” Zeng, D., Salvatore, P., Karlsen, K. K., Zhang, J., Wengel, J. & Ulstrup, J., 1. sep. 2020, I: Journal of Electroanalytical Chemistry. 872, 9 s., 114527. Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives Matta, A., Sharma, A. K., Tomar, S., Cao, P., Kumar, S., Balwani, S., Ghosh, B., Prasad, A. K., Van Der Eycken, E. V., Depass, A. L., Wengel, J., Parmar, V. S., Len, C. & Singh, B. K., 28. aug. 2020, I: New Journal of Chemistry. 44, 32, s. 13716-13727 Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces Zeng, D., Salvatore, P., Karlsen, K. K., Zhang, J., Wengel, J. & Ulstrup, J., 15. maj 2020, I: Journal of Electroanalytical Chemistry. 865, 9 s., 114138. Self-Assembly of DNA–Peptide Supermolecules: Coiled-Coil Peptide Structures Templated by d-DNA and l-DNA Triplexes Exhibit Chirality-Independent but Orientation-Dependent Stabilizing Cooperativity Lou, C., Boesen, J. T., Christensen, N. J., Sørensen, K. K., Thulstrup, P. W., Pedersen, M. N., Giralt, E., Jensen, K. J. & Wengel, J., 4. apr. 2020, I: Chemistry - A European Journal. 26, 25, s. 5676-5684 Adamts-Targeting Gapmers as a Gene Modulation Strategy in Osteoarthritis Garcia, J., Wengel, J., Howard, K. A. & Creemers, L. B., apr. 2020, I: Osteoarthritis and Cartilage. 28, 1, s. S521-S522 Systemic Evaluation of Chimeric LNA/2′-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy Christou, M., Wengel, J., Sokratous, K., Kyriacou, K., Nikolaou, G., Phylactou, L. A. & Mastroyiannopoulos, N. P., apr. 2020, I: Nucleic Acid Therapeutics. 30, 2, s. 80-93 14 s. Gapmer Antisense Oligonucleotides Containing 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing Danielsen, M. B., Lou, C., Lisowiec-Wachnicka, J., Pasternak, A., Jørgensen, P. T. & Wengel, J., 27. jan. 2020, I: Chemistry - A European Journal. 26, 6, s. 1368-1379 12 s. In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages Duschmalé, J., Hansen, H. F., Duschmalé, M., Koller, E., Albaek, N., Møller, M. R., Jensen, K., Koch, T., Wengel, J. & Bleicher, K., 10. jan. 2020, I: Nucleic acids research. 48, 1, s. 63-74 12 s. Albumin-binding fatty acid–modified gapmer antisense oligonucleotides for modulation of pharmacokinetics Cai, Y., Lou, C., Wengel, J. & Howard, K. A., 2020, Gapmers: Methods and Protocols. Yokota, T. & Maruyama, R. (red.). Humana Press, s. 163-174 (Methods in Molecular Biology, Bind 2176). Alpha-L-locked nucleic acid-modified antisense