CHEMICAL UPDATE WORKSHEET

Chemical Name: CAS #: 64-19-7 Revised By: RRD Toxicology Unit Revision Date: September 9, 2015

(A) Chemical-Physical Properties Part 201 Value Updated Value Reference Source Comments

Molecular Weight (g/mol) 60.05 60.05 EPI EXP

Physical State at ambient temp Liquid Liquid MDEQ

Melting Point (˚C) --- 16.60 EPI EXP

Boiling Point (˚C) 117.9 117.90 EPI EXP

Solubility (ug/L) 6.0E+9 1.00E+09 EPI EXP

Vapor Pressure (mmHg at 25˚C) 12 1.57E+01 EPI EXP

HLC (atm-m³/mol at 25˚C) 1.00E-7 1.00E-07 EPI EXP

Log Kow (log P; octanol-water) -0.23 -0.17 EPI EXP

Koc (organic carbon; L/Kg) 0.595 1 EPI EST

Ionizing Koc (L/kg) NR NA NA

Diffusivity in Air (Di; cm2/s) 0.08 1.17E-01 W9 EST

Diffusivity in Water (Dw; cm2/s) 8.0E-6 1.3352E-05 W9 EST Soil Water Partition Coefficient NR NR NA NA (Kd; inorganics) CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

Part 201 Value Updated Value Reference Source Comments

Flash Point (˚C) 103 F 39 CRC EXP Lower Explosivity Level (LEL; 0.04 0.04 CRC EXP unit less) Critical Temperature (K) 593 CRC EXP Enthalpy of Vaporization 5.66E+03 CRC EXP (cal/mol) Density (g/mL, g/cm3) 1.0446 CRC EXP EMSOFT Flux Residential 2 m NA 4.44E-06 EMSOFT EST (mg/day/cm2) EMSOFT Flux Residential 5 m NA 4.44E-06 EMSOFT EST (mg/day/cm2) EMSOFT Flux Nonresidential 2 m NA 5.62E-06 EMSOFT EST (mg/day/cm2) EMSOFT Flux Nonresidential 5 m NA 5.62E-06 EMSOFT EST (mg/day/cm2)

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

(B) Toxicity Values/Benchmarks Source*/Reference Comments/Notes Part 201 Value Updated Value /Date /Issues Reference Dose 5.7E-1 5.7E-1 MDEQ, 1998 (RfD) (mg/kg/day) Tier 3 Source: Complete MDEQ: Basis: MDEQ RfD is the only available value. See details below.

Tier 1 and 2 Sources: IRIS: No IRIS file available at this time. NOAEL of 1.0 PPRTV: No PPRTV record available at this time. g/Kg/d calcium MRL: Per ATSDR MRL List (12/2014), no MRL value at this time. magnesium

in male Tier 3 Sources: and female rats MDEQ: Per MDEQ-CCD/RRD (7/20/1992), RfD = 5.7E-1 mg/kg-day. See Part 201 dosed by gavage, Value RfD details. 5 d/week for 4 Basis: Per MDEQ-CCD (07/09/1998), WRD derived an RfD = 5.7E-1 mg/kg-day: weeks. Critical MDEQ is the only available value. effects = no RfD details Critical Study: Chevron Environmental Health Center, 1987 (unpublished) observed adverse Method(s): male and female Sprague-Dawley rats dosed by gavage, 5 days/week effects. UF=1000 for 4 weeks (Chevron Critical effect: no observed adverse effects Environmental End point or Point of Departure (POD): NOAEL = 1.0 g/kg-day calcium magnesium Health Center, acetate; equivalent to 0.8 mg/kg-day acetate (TWA dose = 571 mg/kg/d). 1987). Uncertainty Factors: UF = 1,000 CCD/RRD date: Source and date: MDEQ-CCD/Water Resources Division; 07/09/1998 7/20/1992

Other Tier 3: No value is available at this time from these Tier 3 sources/databases: HEAST, NTP ROC, health and environmental agencies of California, Massachusetts, Minnesota, New Jersey, New York, and Texas, WHO (IARC), WHO (IPCS/INCHEM), Canada, The Netherlands (RIVM), ECHA (REACH) and OECD HPV. Oral Cancer Slope -- NA MDEQ, 2015 Factor (CSF) 3

CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

Source*/Reference Comments/Notes Part 201 Value Updated Value /Date /Issues (mg/kg-day)-1)

Tier 1 and 2 Sources: Complete IRIS: No IRIS file available at this time. PPRTV: No PPRTV record available at this time. CSF details MRL: NA; ATSDR MRLs are for non-cancer effects only.

Tier 3 Source: MDEQ: Per MDEQ-CCD, no value at this time. Reference Concentration (RfC) or Initial 2.5E+2 2.5E+2 MDEQ, 1992 Threshold Screening Level (ITSL) (µg/m³) Tier 3 Source: Complete MDEQ: Basis: MDEQ ITSL is the only available value. See details below.

Tier 1 and 2 Sources: IRIS: No IRIS file available at this time. Based on 1 % of PPRTV: No PPRTV record available at this time. TLV, calc'd under MRL: Per ATSDR List (07/2013), no MRL value at this time. interim process RfC/ITSL details for developing Tier 3 Sources: screening levels. MDEQ: Per MDEQ-CCD (07/14/1992), AQD ITSL = 2.5E+2 µg/m³ with 8 hour (07/14/1992) averaging time. Basis: Based on 1 % of TLV, calculated under interim process for developing screening levels. MDEQ is the only available value, Source and date: MDEQ-AQD; 07/14/1992

Other Tier 3: No value is available at this time from these Tier 3 sources/databases: HEAST, NTP ROC, health and environmental agencies of

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

Source*/Reference Comments/Notes Part 201 Value Updated Value /Date /Issues California, Massachusetts, Minnesota, New Jersey, New York, and Texas, WHO (IARC), WHO (IPCS/INCHEM), Canada, The Netherlands (RIVM), ECHA (REACH) and OECD HPV. Inhalation Unit Risk Factor NA NA MDEQ, 2015 (IURF) ((µg/m3)-1) Tier 1 and 2 Sources: IRIS: No IRIS file available at this time. Complete PPRTV: No PPRTV record available at this time. IURF details MRL: NA; MRLs are for non-cancer effects only.

Tier 3 Source: MDEQ: Per MDEQ-CCD, no value at this time. Mutagenic Mode of Action -- NO USEPA, 2015 (MMOA)? (Y/N) NA -- MMOA Details Not listed as a carcinogen with mutagenic MOA in the USEPA OSWER List. Developmental or No, the RfD nor RfC is not based on a reproductive- NO MDEQ, 2015 Reproductive developmental effect. Effector? (Y/N) Developmental or Reproductive NA NA Toxicity Details State Drinking Water Standard NA NO SDWA, 1976 (SDWS) (µg/L) SDWS details MI Safe Drinking Water Act (SDWA) 1976 PA 399 Secondary SDWA, 1976 and Maximum NA NO Contaminant Level USEPA SMCL Lists (SMCL) (µg/L) SMCL details NA MI Safe Drinking Water Act (SDWA) 1976 PA 399 and USEPA SMCL List

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

Source*/Reference Comments/Notes Part 201 Value Updated Value /Date /Issues Is there an Aesthetic Value? NO Not evaluated. NA (Y/N) Aesthetic value NA NA details Phytotoxicity NO Not evaluated. NA Value? (Y/N) Phytotoxicity NA NA details Others

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

(C) Chemical-specific Exposure Factors Source/Reference/ Comments/Notes Part 201 Value Update Dates /Issues Gastrointestinal MDEQ, absorption --- 1.0 2015/USEPA RAGS- efficiency value (ABSgi) E ABSgi details RAGS E (EPA, 2004) Default Value Skin absorption efficiency value --- 0.1 MDEQ, 2015 (AEd) AEd details Ingestion Absorption 1.0 MDEQ, 2015 Efficiency (AEi) AEi Details Relative Source Contribution for 0.2 MDEQ, 2015 Water (RSCW)

Relative Source Contribution for 1.0 MDEQ, 2015 Soil (RSCS)

Relative Source Contribution for 1.0 MDEQ, 2015 Air (RSCA)

Others

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

(D) Rule 57 Water Quality Values and GSI Criteria (as acetate)

Current GSI value (g/L) (G)

Updated GSI value (g/L) (G)

Rule 57 Drinking Water Value (g/L) 16,000

Rule 57 Value Verification Date (g/L) Human Non-cancer Values- Drinking water source (HNV-drink) 16,000 7/1998

Human Non-Cancer Values- Non-drinking water sources (HNV-Non-drink) 1,300,000 7/1998

Wildlife Value (WV) NA NA

Human Cancer Values for Drinking Water Source (HCV-drink) NA NA

Human Cancer values for non-drinking water source (HCV-Non-drink) NA NA

Final Chronic Value (FCV) EXP(0.2732*(pH)+7.0362) 7/2004

Aquatic maximum value (AMV) EXP(0.2732*(pH)+9.2333) 7/2004

Final Acute Value (FAV) EXP(0.2732*(pH)+9.9265) 7/2004 Sources: 1. MDEQ Surface Water Assessment Section Rule 57 website 2. MDEQ Rule 57 table

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

(E) Target Detection Limits (TDL) Value Source

Target Detection Limit – Soil (g/kg) 20,000 MDEQ, 2015

Target Detection Limit – Water (g/L) 100 MDEQ, 2015

Target Detection Limit – Air (ppbv) NA MDEQ, 2015

Target Detection Limit – Soil Gas (ppbv) NA MDEQ, 2015

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

CHEMICAL UPDATE WORKSHEET ABBREVIATIONS: W9 USEPA’s User Guide for Water9 Software, Version 2.0.0, 2001 CAS # - Chemical Abstract Service Number.

Section (A) Chemical-Physical Properties Reference Source(s): Basis/Comments: CRC Chemical Rubber Company Handbook of EST estimated and Physics, 95th edition, 2014-2015 EXP experimental EMSOFT USEPA Exposure Model for Soil-Organic Fate and EXT extrapolated Transport (EMSOFT) (EPA, 2002) NA not available or not applicable EPA2001 USEPA (2001) Fact Sheet, Correcting the Henry’s NR not relevant Law Constant for Soil Temperature. Office of Solid Waste and Emergency Response, Washington, D.C. Section (B) Toxicity Values/Benchmarks EPA4 USEPA (2004) User’s Guide for Evaluating Sources/References: Subsurface Vapor Intrusion into Buildings. February ATSDR Agency for Toxic Substances and Disease Registry 22, 2004. CALEPA California Environmental Protection Agency EPI USEPA’s Estimation Programs Interface SUITE 4.1, CAL DTSC California Department of Toxic Substances Control Copyright 2000-2012 CAL OEHHA CAEPA Office of Environmental Health Hazard HSDB Hazardous Substances Data Bank Assessment MDEQ Michigan Department of Environmental Quality CCD MDEQ Chemical Criteria Database NPG National Institute for Occupational Safety and ECHA European Chemicals Agency (REACH) Health Pocket Guide to Chemical Hazards OECD HPV Organization for Economic Cooperation and PC National Center for Biotechnology Information’s Development HPV Database PubChem database HEAST USEPA’s Health Effects Assessment Summary Tables PP Syracuse Research Corporation’s PhysProp database IRIS USEPA’s Integrated Risk Information System SCDM USEPA’s Superfund Chemical Data Matrix MADEP Massachusetts Department of Environmental SSG USEPA’s Soil Screening Guidance: Technical Protection Background Document, Second Edition, 1996 MDEQ/DEQ Michigan Department of Environmental Quality USEPA/EPA United States environmental protection agency’s DEQ-CCD/AQD MDEQ Air Quality Division Risk Assessment Guidance for Superfund Volume I: DEQ-CCD/RRD MDEQ Remediation and Redevelopment Division Human Health Evaluation Manual (Part E, DEQ-CCD/WRD MDEQ Water Resources Division Supplemental Guidance for Dermal Risk MNDOH Minnesota Department of Health Assessment). July, 2004.

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CHEMICAL UPDATE WORKSHEET Acetic Acid (64-19-7)

NJDEP New Jersey Department of Environmental RfC Reference concentration Protection RfD Reference dose NYDEC New York State Department of Environmental p-RfD Provisional RfD Conservation aRfD Acute RfD OPP/OPPT USEPA’s Office of Pesticide Programs UF Uncertainty factor PPRTV USEPA’s Provisional Peer Reviewed Toxicity Values WOE Weight of evidence RIVM The Netherlands National Institute of Public Health and the Environment Section (C) Chemical-specific Absorption Factors TCEQ Texas Commission on Environmental Quality MDEQ Michigan Department of Environmental Quality USEPA United States Environmental Protection Agency USEPA RAGS-E United States Environmental Protection Agency’s USEPA OSWER USEPA Office of Solid Waste and Emergency Risk Assessment Guidance for Superfund Volume I: Response Human Health Evaluation Manual (Part E, USEPA MCL USEPA Maximum Contaminant Level Supplemental Guidance for Dermal Risk WHO World Health Organization Assessment). July, 2004. WHO IPCS International Programme on Chemical Safety (IPCS/INCHEM) Section (D) Rule 57 Water Quality Values and GSI Criteria WHO IARC International Agency for Research on Cancers GSI Groundwater-surface water interface NA Not Available. NA A value is not available or not applicable. NR Not Relevant. ID Insufficient data to derive value NLS No literature search has been conducted Toxicity terms: BMC Benchmark concentration BMCL Lower bound confidence limit on the BMC BMD benchmark dose BMDL Lower bound confidence limit on the BMD CSF Cancer slope Factor CNS Central nervous system IURF or IUR Inhalation unit risk factor LOAEL Lowest observed adverse effect level LOEL Lowest observed effect level MRL Minimal risk level (ATSDR) NOAEL No observed adverse effect level NOEL No observed effect level

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